<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMR4</accession>
    <name>A0A1Q5SMR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_13868</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SMR4"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="534"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="757"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1385"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2201" mass="248419" checksum="BF790D714EA3A7EE" modified="2017-04-12" version="1">MADQNISQYKYSAMSNLVLQADRRFISRVNDEPTGDPESLAGRIGIREMGARVARDDVPKSKKKTAADLERGAIHEGEDVLLREQRKRQRGQPAQQRGQGILSAADALIEGLKYRPRTPATRATYDLILTITGTNLGDVPHEVVRSAADAVLELLKDEDMKDFDKKKEIDDLLGTSMNPKEFNELVNLGKKITDYDAEDEDEDMDGGLDEGEGELDERQGVAVVFDEEDEDEDRMGTVDEIRDEDSDEDELDELDQPKGEGSAEELEEADEMVLDGGLDRADKAKDKSGLTVSAREIDAYWLQRQIGAVYPDAHIQQEKTKEALDVLGGQAEDGTEKPLRDVENDLMELFDYDHPDLVAKLVSNRTKVVWVTRWRQVAEDADARNLVESQMVEAGHRAVLDEIRGKTTDDLAHRPEKIKLDLMDVDVPSAPEAQEQKQVGENGLVGGLQPKRLINLENLVFHQGNHLMTNPNVKLPQGSTKRTFKGYEEIHVPPPQAKKLPGEKNIPTTDLPDWARVGFGSSKELNRIQTKCYPTAFHDDGNLLVCAPTGSGKTNVAMLTILREIGKNRNPETGEIMLDDFKIIYISPLKALVQEQVGNLGKRLEPYGIRVAELTGDRQLNKQQIADTQIIVTTPEKYDVITRKASETSYTNLVRLIVIDEIHLLHDDRGPVLESIVSRTIRRVEQTGDPVRIVGLSATLPNYRDVASFLRADPETGVFHFDGSYRPCPLKQEFIGVTDKKAIKQLKTMNDICYNKVMEQVGQKRNQMLIFVHSRKETAKTAKYIRDKAIEMETIGQILRSDAASRAILSEEADSVDDASLKDLLPYGLGIHHAGLSLADRDSVQALFADGSIQVLVCTATLAWGVNLPAHTVIIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQYDTFGEGIIITSQAEIQYYLSLLNQQLPIESQLMSKLADNLNAEVVLGNVRTRDDGVEWLGYTYLYVRMLRSPGLYSVGADYENDDALEQKRVDLIHSAATVLERAGLVKYEKKTGRLQSTELGRISSHYYIGHNSMLTYAQHLQPSITTIELFRIFALSDEFKYIPVRQDEKLELGKLLGRVPVPVKETIDEPHAKINVLLQAYISRLKLEGLALMADMVYVTQSAGRIIRAIFEICLKKGWSSVAKTALDLCKMAEKRMWPTMSPLRQFPGCPRDILQKAERIDVPWPSYFDLDPPRMGELLGMPKAGRVVCDLVSKFPRLDVQAQVQPITRSMLRVELTISPNFVWDDAVHGNAQDFWILVEDCDGEEILFHDRFLLRREFAISEMNEHMVEFTVPITEPMPPNYFISLVSDRWMHSETKIAVSFQKLILPERFPPHTPLLDMQRAPVKALKREEYQKLYPDWEHFNKIQTQVFKSVFDSDDNVFIGAPTGSGKTVCAELALLRHWSAENEGRAVYIAPFQELVDLRLADWEKRLGGIGGGKTIVKLTGETTADLKLLEQADLVLATPVQWDVLSRQWQRRKNVQTVQLFIADELHMLGGFGGYVYEVVVSRMHYIALQTENEMRILGLSVPLSNARDIGEWIGANKHTIYNFSPHARPVPLELHIQSYTIPHFPSLMLAMSRPAYQSILQLSPDKPALVFVPSRKQTRSTAMDLLAACAIDDNEDRFLNADVEELAPLLSRVQEQTLATSLSHGIGYYHEALSQTDKRIVSHLFSIGAIQVLLASRDVCWELNVTAHLVIVMNTQFFDGREHRYIDYPISEILQMFGKASRPGVDKSGRGVLMVPAVKREYYKKFLNEALPVESHLQVYLHDAFVTEASTRTLASTQDAVDWMTYTYFYRRLLANPSFYGLSDVSHEGLSTFLSELVETTLKELSDAKIIDLDEEDDSVSPLNAAMISAYYNISFITMQTFLLSLSARTKLKGILEIVTSATEFESVQMRRHEDHILRRVYDRVPVKMSEPAFDSPHFKAFVLLQAHFSRMQLPIDLAKDQEDIVRKVLNLLSACVDVLSSEGHLNAMNAMELSQMVVQAMWDRDSPLKQIPHFSPEVIEVAKEYEINDIFEFMEAMDPSENKDYATLVKRLGLNNKQLAQAAAFTNDKYPSIELDFEVEDPENVTSGEPAYLKVKIQREVEEEDEVDTVVHAPFYPNQKMENWWLVVGEEKTKNLLAIKRVTIGRKLDLRLEYVVPTPGEHELTLYLMSDSYVGVDQAPTFTVNAAEGMEEDESEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNG6</accession>
    <name>A0A1Q5SNG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal peptide synthetase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNG6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="129"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="302" mass="33776" checksum="560C3B6D7600D9D8" modified="2017-04-12" version="1">MKERGEDTISGAKLSHSRHVCTASLKYLTKSFQLLTPLTSLTGNLELVVIRRDNRLSASIKKPENVPNELDQSMLWTFQHVLRQITSYPASLKLEAIDYCSESHKKIIKSQTNTISAQNLHCLHDLILENCQRHPKRLAVRSFDGDLTYEELNILSLRLALHLAQLGVRPETFVLSSFQKSTWAIVARLAILRAGGAYISIHSSNPPAYLNSVIRRTGAKVMLSDPVFADQFHNAIETVIVITPEWLQTLPLQIQLAPLQPTQPFNACTILFTSGSTGRPKAIVQEHSPTHQLSETMPRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNM4</accession>
    <name>A0A1Q5SNM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNM4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6087" checksum="37CA037A640AB495" modified="2017-04-12" version="1">MANQCSGHKFAIVQATNGNILTWRCSDCNSGPFVAIWRCKICGHCRCNSCHNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT4</accession>
    <name>A0A1Q5SNT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress protein DDR48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="30635" checksum="3DECA6310DBFED3F" modified="2017-04-12" version="1">MSYNNDNDRSYGSGGSDSYGSSGRNDDNDNSYGSSNRSGNDSYGSSNNNDSYGSSNNDSYGSSGRGGNTSSYGSSGRDNDNDNSYGSSKKDSYGSSNNDSYGSSNKSDSYGSSNKDSYGSSNNDSYGSSGRTGNTSSYGSSGRNNDNDDDNSYGSSKKDSYGSSNTDSYGSSGRNTDSYGSSDKSDSYGSSKKDSYGSSNNDSYGSSNNDSYGSSNKSDSYGSSNRSGNDSYGSSNKDSYGSSNNDSYGSSNRSGGDSTFGKVLEKAGDLLGSDSLQERGQERREQKRSDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNV4</accession>
    <name>A0A1Q5SNV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING-box protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_13755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNV4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNV4"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO89689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="118" mass="13326" checksum="1201F188A4028A9D" modified="2017-04-12" version="1">MADVEMKEASASSSKGKAVAKGGDGASDKKKFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQGSSTNEECTVAWGICNHAFHFHCISRWLKTRQVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP12</accession>
    <name>A0A1Q5SP12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP12"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="215" mass="23737" checksum="0E8189AE9DE817AD" modified="2017-04-12" version="1">MLTGRLNDAAILLHLSLDNNHIRYAVIGGYPITHFGGNRQTNDIDCIAIASKQQINNAIDPEAGLAVISQHRDDYIGLSWSDRPDRSDPVLIHIHCSVYPGSRFPNALFRFETHEVKGHTMGNGMAALRAAGSRSNFVDSVDLRWLAQRYVIEIKARRHKIHLVDVGRALQQHSNLENVFESLGIDIAKAKIAAKGPPRGVEDISKGLFDSLADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRV9</accession>
    <name>A0A1Q5SRV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRV9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO90605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="57026" checksum="E4AD4D052B0FFC2E" modified="2017-04-12" version="1">MGRLNGTRLGAFRAYFFGFFVCTAGFLFGYDTGIVGGILTFQSYKDDFRYNDKTTVSAVMVSLQNVGAFLAALCIFPISERFGRKKTVQVAMSIFCVGVILQVVPSHSLVCFYIGRFVSGLGLGAGTAVVPSYNAEMAPKEIRGMLGSGVQWLFALGVMISYWIDYAVEKTLPVSSAQWQIPIGLQLVPATVLALGLFTQPESVRWLAKKERYEEAWQSLTWMRASEGPEVKAEFNEIKTGLAEELRATDGLKKRELLEPANRYRLALAVFIFCGQQCTGMTALAYFGPQFFKLLVGNDSSRSLLITGLFGAEKFIAVGIYILFFSEMWGRKPTLWISALLMSVCFVIVTVVNNTTPKPQQEVTSSGIATVAMIFLTNSIYQFSWGPLPWPYTTEIFPSRIREIGSSVAVATQWLFNFLFSLVTPYMQSSWGSYTFLFYAALDVIMAIIVWFFVKETKGKSLEEMETIFNSKAAFDVEIARHEGEEISDHVSALEVHNKGDGSAKGSDEEDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSB0</accession>
    <name>A0A1Q5SSB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSB0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1230.10:FF:000005">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone]alpha subcomplex assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="228" mass="24683" checksum="7A3CB55B51B7EEA0" modified="2017-04-12" version="1">MRSSLLTAPTSRPLRSATSFPRALTAIDMPSQKRNYSSPIRPTRMIPRSHTHKPTSHDRGPESKEDTQTDFGALDVLGNTPVPSTAIDACLDSGFHLNSGVKITGGDALLLVGGEAFSWRPWKAFEGAENDRAAKASMINAKGQFELDEQAWGLLSVVWPRPDMLILGLGGGMYPLSPETKRHINALGIRVEIQDTRNAAAQFNLLATERGVSEIAAALIPIGWKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSQ7</accession>
    <name>A0A1Q5SSQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSQ7"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="213"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO90905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118034" checksum="FBA2CEA6FA14D6C8" modified="2017-04-12" version="1">MATSFISKRLRATEADQDAEPSWIRRQVTSGLQCISRRACVHPIHTIVVIALLASTTYVGLLEGSLLDTARNPRNVAGQVDQIEQPAARHLALTTFIFPDSNFKSASTAPAVEDVPVPANVSAHPVPHTPNLFSPFSHDSSLAYTVPFEQVPDFLRAVQEIPNPSAEEEEEESKKWIMKAARGATGSRTALKLWITDAWSSFVDIIKHAETIDIVIMALGYLSMHLSFVSLFFSMRRLGSNFWLAATVLFSGSFAFLFGLLVTTKLGVQINLLLLSEGLPFLVVTIGFEKPIMFTRAVLKASVDNRRPRPGAAPRPLTSSTPGSIQDSIATAIKAQGFEIIQHYCIEIGLLAMGAASGVQGGLQQFCFLAAWILFFDCVLLFTFYTTILCIKLEITRIKRHVALRKALEEDGITHSVAENVASSNDWPTAGSDGSEGDTSIFGRKIKSSNVRRFKILMVGGLILINVVNLSAIPFRNTGNGALISRLSNVMAPAPIDPFKVAENGLDAVYVAAKSQKQETMVTIIPPVKYKLEYPSVHYAPNEDSGSFDIEYSDQFLDAVGGKVLESLLKSVEDPIISKWIIAALTLSIILNGYLFNAARWSIKEPEPVIDAPKEPVAPKVYPKFEPNEEESTRTMEECEVMLKQKRAPFLKDEELIALSLKGKLPGYALEKTMENEELMSRVDAFTRAVKIRRAVVARTPATSATTSSLETSKLPFEHYNYGLVHGACCENVIGYLPLPLGVAGPINIDGQNYFIPMATTEGVLVASTSRGSKAINAGGGAVTVLTGDGMTRGPCVTFPTLARAAAAKVWIDSEEGKSIITAAFNSTSRFARLQSLKTALAGTYLYIRFKTTTGDAMGMNMISKGCEKALDVMSKECGFDDMSIISLSGNFCTDKKSAAINWTDGRGKSVVAEAIIPGDVVKSVLKSDVEALVELNISKNLIGSAMAGSLGGFNAHASNIVSAIFLATGQDPAQNVESSSCITTMKNRNGDLQIAVSMPSIEVGTIGGGTILEAQSAMLEMLGVRGAHPTTPGENARQLSRIIAASVLAGELSLCAALAAGHLVRAHMAHNRSAAPTRSSTPVSAAVGATRGLSMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUT7</accession>
    <name>A0A1Q5SUT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUT7"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="169"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO91635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="433" mass="48812" checksum="1E299AD3BC6CF4A6" modified="2017-04-12" version="1">MFLFDVLQRTYTVVFPPTAPKNDDAIRIGLLGASKIAPFVVVNPAKSHPDVIVAAVAARDIERAKKYAKTHGIPIVHASYQELIDDPAIDAVYVALPNGMHYEWALRSIHAGKHVLLEKPSCSNAIEAKKLFNHPLTTAKNAPVLLEAFHYQFHPGFQTFLSEVRKSPGAIKNVRAEFHLSPGILGSEDIRFRYALGGGCMMDAGTYPLSIARQILGREKILEPIDVRYRGVQPGKDGRVGEPQIDEAMEATYRTAESVNVHVSGDLLHKGKWPSFFPASWTRALPSFKWPKASVTFEPVLVDMPNGEDNNSSQHFVQRTLTMWNPLIPTFYHRIDISDEHTLRQGDHVTKTWNETKYKTAYNWPEGDRRAAVYKDWWTSYRCQLEEFVNRVKGREGSGVWIDGAESIAQMEVIDRTYEKAGLKPRPTSTFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUY2</accession>
    <name>A0A1Q5SUY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000745">
        <property type="protein sequence ID" value="OKO91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUY2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="51" mass="6179" checksum="1F74D171BF0A2776" modified="2017-04-12" version="1">MTILVHNQNVEARYLSRRNTRLLNTFTRRETSQDPITELQNQQSRQKYIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWT2</accession>
    <name>A0A1Q5SWT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWT2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWT2"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="21850" checksum="852640F1B6A357DC" modified="2017-04-12" version="1">MAGISAAIKKDHRDIEEYYKNILASSTDKEKTQWQNQFTWELARHSIGEELVVYPQFEKNLPDGQRMADKDRQEHLSIKEQLKTFQNMQPSDPQFEPTLKALMKDLSEHIKEEESNDLPKLEDSISAKESDDLSKSFARTKIFVPSRSHPSAPDKPPFETAVGLMTAPIDHLADLFRTWPHTSGMPNPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ31</accession>
    <name>A0A1Q5SZ31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ31"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="25962" checksum="080B7D6DBEF26B6C" modified="2017-04-12" version="1">MLQGGQVQHLAARARGVKERISTITSYRSSVPTVYDSSYMTNIRPYANLNSLYPEWIQYRLRKLGDEINNYLNKIENEPELALDKVQLETLINEQAEYLRQTSRQMVSPEEGQRILKKYGSTAYYDAPRIWIKVQSLPEFNITASSADKNRLWMPGSTYWLDLQSSIETLRLGKSLKSTMGNLTWDDKRQYFMGDELMRQGLNEMFLDWLGVSGLWDLYCKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ63</accession>
    <name>A0A1Q5SZ63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ63"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="237" mass="25827" checksum="33F77473297EB379" modified="2017-04-12" version="1">MPSIITNPNMPASNSTLSKRRRFQAPITSFFPSASAASESADGHTVSHNHYSASTFSATPVVPAKVQASLLSVGMRVRKSVADGYKTQLSLNAEKAKIAVVASEPRLAQPYYGNNSYAELPPFSGFSKSANDPYSVNTDDGDAFSLPPSSQESITSTASYASTNGHKRSFDFGNDVYAYKDSGNEAPRGRTILSPRRRLLTQNTSNLPKMDLDDFEEASFLRQREEVDSDYLRMDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ84</accession>
    <name>A0A1Q5SZ84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ84"/>
    <dbReference type="OrthoDB" id="4477950at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010385539" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="11359" checksum="47FE146002822FB6" modified="2017-04-12" version="1">MQLTSILGLCLVGLATSAAAMPRIAGPYHGKPLAVHVPVNLTTTANKASTTGSLVKKPLTTGAHHSPQMQNSPNLPNHIKHINHCTELCSLEAQTCNIAVPDDDKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0V5</accession>
    <name>A0A1Q5T0V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0V5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0V5"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="172" mass="19120" checksum="C5E0FD4E344028F9" modified="2017-04-12" version="1">MADDEGASPRELVVEACRRDQPHLIEQVLHDMENQSNEDVAKFFNEVTDTMGNHALHICASYGSYDVMDALFDIQYFECDPLTRVDKDTPLHTAVRFANEKDAELGAEMIAMMCEAGCDPRVRNKHGQKPADLVYDKPAIKQTLASAEYILAEGIRNDEGNGSIHDSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0W0</accession>
    <name>A0A1Q5T0W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWI/SNF and RSC complexes subunit ssr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0W0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0W0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10568">
        <property type="entry name" value="SWIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="52271" checksum="BB8B06C8C3FF8906" modified="2017-04-12" version="1">MPVPMPQHAVNPQYMAAQRAMPHPNDAVLRRSRKPTDKNIPEGIEDVIIGEGVEQYKNLRDLEKRLDAAIVRKRLDIQDSISKTVKKYRTLRIWITNTVENQPWQGVGSNPGSGRYKVRIEGRLLDDDNDPTVPEDEDEGENGDAMEQDKDAAEGSKKTGSKKPSQRFSHFFKTITVDFDKPASNATDEVKPVTWTKPQVPANATSAPANAEFDSIQFARSSQENVNVTISLVRDETPERYKLSKELAEVLDVEEETRSGIVLGIWDYIRAMELQEDEEKRQVRCDHRLRSIFGRDQMFFPQIPDSIGPHTSPMDPIKLPYTIRVDEEFHKDATPTIYDIQVAVEDPLRQKMMALTQNPQYTAGLRQIAALDDQVALIVQALTHSRARHSFYTALSKDPATFLRRWVNSQRRDLETILGDANGVGDGSGPEFRRGGPESAWETPVAKEAVRYMLAKPEAAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1F7</accession>
    <name>A0A1Q5T1F7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_11898</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1F7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1F7"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="222"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO94063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="45320" checksum="71DC575B31DC1874" modified="2017-04-12" version="1">MAEAWSNVCRQCIATVSDVPPTILLAAATATGLGLFVLFVTFLFIVAPTPRDPLPEEKKYKTLAKDGAITNPESLPGWLDNLNAQKRASKNPEIEPAELFMSVVVPAYNEEDRLAGMLEEAVNYLEHMYGTPGRDEEKEASTVSTRSTRKRKTATNGQATNGHATGSASDRGWEILIVSDGSTDRTEEVAFSFARDHQLSMHPKGYAGPWTPKAQEGVHIPPGTIRVVSLTHNRGKGGAVTHGMRHARGQYVVFADADGASKFEDLGKLVKACQDIEDAGGRGVAVGSRAHMVGSEAVVKRSKLRNFLMHSFHMILWLMTPPKTATVKDTQCGFKLFSRNSLPFIVPYMHSEGWIFDVEMLMLAEFARIPVAEVPVGWREVGGSKLNVIRDSIGMAWGLAVLRAAWSLGIYRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T293</accession>
    <name>A0A1Q5T293_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T293"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="77" mass="8842" checksum="BE8CDA55EE2414D1" modified="2017-04-12" version="1">MLEDLEKFLKEIITKFEELAVPIMSFLDGHWQSRITEYISAHDLFDEGHVRNARAAGIDLVAEETPAPEWVKLLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5M6</accession>
    <name>A0A1Q5T5M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5M6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="733" mass="81346" checksum="A95E91AB456E3BB4" modified="2017-04-12" version="1">MDTDKSSNDAGFHERLTRHSSAFSLSLSFRGSSKRGSSRQSSHLRRIFRRSELRTSSSDFPGQTDGTPTFPRRTLHKARSGLLALRAGLFGRPPPQGNDPFENETKSLPKQGHTHRRTHGFSDISSSTQEDLNFGTDLYRNGRAQPRTLDDLDGNVVKQVPSFHPLKNTVSAPQPRTSSCVLVDDSEPAFDQTVSTPADQPFAYESYQDNIVTSHIPDEETFAEPNPSIIEDIQKDRADYLTPSVASEDRHTPGSLSANSTDEDNLGGTSLQCYKQNVDSEQKRDLMKNWLDHEQCACEQIEELRQLSETRNVPSLEMQLKRNDSSESLALPDYSTPSLAGSKTPEQRGSLVIRTKAPVTQERVLLGDDSLEPQACESPVSESRKCSANVKIAFPGLYHELLEQWVRENELSPTLDPEFPRLESETTLSTVHLPSIASTTSSHLNPNSQPHHPTELPWSLDTHLNTGLAHILNNFHKGNALVSFTPLACPRVVTAHCVQDSITFPCNMDDYTRQARQAQANTENTGTREVQSDRRRHSFGIHVSERNESASRSSSTQVSRPEILRRSSEDQQRPVNDPPFPPHPGLWGAADSQCDSDLSTSYNQDNSAINSANYTSPTSISSAPWSPLDSPIDEEALFRATHRDEYWMADGKNSSYYPDRGDLPVKGEHVAGDGRIFYASGSGRGSSSRVRQLTRADFSNTMQRSFRRDAQASEEQDDGEPDEDAPPSSQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5M7</accession>
    <name>A0A1Q5T5M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5M7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="57" mass="6519" checksum="E7DBB40F260853AC" modified="2017-04-12" version="1">MERSLRRHAFLMQTWTPGTSTVPIVSVPNPTVQQHLYNAFFVKSKSTGHTCRVMKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y8</accession>
    <name>A0A1Q5T6Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="367" mass="41337" checksum="C26F020C13952B91" modified="2017-04-12" version="1">MGQYLQGTQKSVQAWTVHGLAVKAALQLGLQSRNASKSFPPLEQETRKRIWYGCVVLDRTLSMTFGRPSSIPDYYVRLELPSKRDFERSSAFVDDETSYLSVSFFNSTITLYKQLWNILDLLYGQNIGCDTPLSVSETVAHIFSMEQHLFTWERSLHPSLQLVSTTILNGMPLDQTSPSPQYFSWKFRVILTLRYLNLRVLLHRPVLVKFIAASRYPDRDQQDLKILQQIGMNTFNAAVVLIGAVWVYRDTALCNASMTAQAKKVQQYPARAVMALSKLDDGNRLIDRCRYSLEQFNKILVDPEADLEGLMPTLPALASARGSNPAADFSLSPIGMELGEFMMDDDLVAMIDKHGLLPHDAGSAYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8L1</accession>
    <name>A0A1Q5T8L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8L1"/>
    <dbReference type="OrthoDB" id="4403049at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="8069" checksum="415F45CB029AAF03" modified="2017-04-12" version="1">MANSIQSPSTNPDERMRQAVQRFSTTMESSDRQLLQDRINKIQAMSLSTKEEKIRKMRSYWPDLCADAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8P6</accession>
    <name>A0A1Q5T8P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8P6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8P6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="202"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="583" mass="64364" checksum="4EAEA63E3461A746" modified="2017-04-12" version="1">MVAPRNTAFAEESAEVEVLYANLEKLNRLTKKIQGSLVRLETSGKVVKEAIGPIYSNTQSLQITNSNIDKVNDAIERLRQPLDAKSREEGIIRAGPQSSGLSQYLSAMKRVEKALVDLNATNLRSNQKALSDFNALLSTGSNMLQDTFKAELMQHVTPIEPLHYLTKDVRGPYLNASLQNLSIASLNTVKRRPTDGPYKQGTNGIGIYSNALEGFIVVEHGIIVQIFTGDQQGLVLQATFLSAMGEYSKTLRELNQYIKANLMTDCFLAFEIIEIVTAMSYRIDSKTAELKSLLIEALRPVRETAKSSLSELLEETKRKAATVPLPPDGGSIPLVDEVMSSLATLTGYSGPLASILTSLGDGNWRSNSNTASTAPLDVGPDSGTLFSHFILDMIEALMTALEARGRTFHRTKAALGVFLSNVFCVVDRSIRSSPELARYLGAPDSIARIDSFRKRATSTYLDAWKDTSQCLLDVQYTSRTGARPSSGGAVDSSAIVKNLSSRDRDAIKEKFKCFNASFDEMISRHKNLHMEREVRSVLSRELQTVLEPLYSRFYDRYVEIDKGRGKYIKYDKASLAVQLAQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAM0</accession>
    <name>A0A1Q5TAM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAM0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAM0"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="727" mass="78996" checksum="EA071C84B0A248FA" modified="2017-04-12" version="1">MPEPLSESSGPVQSIRRAVTLPTKLHPQAQRGSAAPNLSENVIFYHPSAKIVHFAPRALVPIPSSSAPSDFDYPVDTIETLPWRSATERTVATAPLRLERGLTVFLKCGNVVRAILKNSQCWCVDGVSKFVLRIRPLTYYRIELPHETAEDKVLVEDLKAALPTVLRYEVTPCPFKRAFTVDLPEEAMAPRRKKAWKPKERKDGVPSLLGSNQGFLCDGRSDWLDSASTGDDTDGAATDDSGFTPQRTDSMTSEAVPVSEESPVFIADADNSSHPALARRCVTEMPQTFTSLRAKFDAPPVLEEPSASEKPETEEQARVLDSEPARNEPVVEETNKTDAYLSSRDPAEAKEASIMGDAPESEDPSTTEVILELPATVQEETSSLDDLQDQGAPSVAIKVAVLEGDLSFVPPEATSSSVQVPIPGETDREPEHQVISGSQEAPIQAEILLPPKTIVPEESSISEDLMAEPVPVLHEDSGSEPDHDSSFASSPESFHSVDIPSFRVEHSSHTTSADAASRSGPSVATSVAEFAAKQASMAESPDHDLLPGTDVTNVRHSPEVETSLPELRMPKYIVREDPPKKSSSSIPSGKKLAVTHATSPVTDFHHMSTEFRRRAQATRRRDVSPMPPSSTIYQSAPNDHASSLLSKALSLVLVPPIHLFIILLHVAARIVISPARNSTLVDSSSGSQSSNNDPDTEDDFSFPLEREPSSEYEDAAMSRKLDPWDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBC3</accession>
    <name>A0A1Q5TBC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBC3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7844" checksum="6293FD238C606717" modified="2017-04-12" version="1">MPAKHAKAWVSSVYGPYHAKPAYRKTYFLHQPVSPASKPRHFTRFPEMGHQDCCYRPNMMAWKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCJ4</accession>
    <name>A0A1Q5TCJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_9863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO97937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="483" mass="54165" checksum="95D663ABDBC32F15" modified="2017-04-12" version="1">MASQTEAVTTAHEHSSAAPGHGITETEPDSASASAPAPASKGKKRRSKYRHVAAYHAQLRHSSLSRDADVTPSFLGFRNLMVLYGVLICIKCHDYRKQDVVLGSILFALVPCHLFLAYAIELSAAGAAKQTVGHQKKTAEEKERDQQVFRSTWRYTALLHTVNATICLALTSFVVYFHIHHPGIGTLCQLHAIIVWLKNCSYAFTNRDLRLAFLNPSADPGLPEIYATCPYPRNVTLKNLAYFWMAPTLVYQPVYPRTTSIRWSFVAKRLAEFFGLAVFIWLLSAQYAAPVLRNSIDKIAVMDIASILERVMKLSTISLIIWLAGFFALFQALLNALAEVMQFGDREFYTDWWNSSSLGVYWRSWNRPVYLFMKRHVYSPLVGRGWSPLAASGMVFGLSAILHEMLVGIPTHNFIGVAFFGMMFQLPLITLTAPLEKMRGPQGKTIGNCIFWVSFCLVGQPLGALLYFFAWQAKYGSVSRMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCM6</accession>
    <name>A0A1Q5TCM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCM6"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="37260" checksum="E421B106D00C9E5F" modified="2017-04-12" version="1">MGTRFKGDTKDPAVNVTTWVLLVTIILSVSVRLGTKWRLFHKLTADDVLIVTSMAFGIAQSIMVNLAVASGYGKPFKEVSSDQFEDVMKYLYVASLMYIVSLALSKLSLAVFIRSLTPSTRDKFVAHVVKGVTYVWAVVVFFGSAFQCEVTRTWDFWNGRCLDILAWRYFVCGSVIVTDLLIFAQAMVLILSIQTSLQRRLIFAGIFLPRLLVVVATITELTYLKKETTNPTYTLCEITIFEVIIQCLSIVTACWGQLNPFLSWMRSNGFKIQGVGDTATYSYKLSSLRRDQILVTQDWEVNSQSSRAQIILEGTWPENTSQQSPDELSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCV3</accession>
    <name>A0A1Q5TCV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCV3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCV3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="774"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1146" mass="129486" checksum="B6F1902B6DF8941D" modified="2017-04-12" version="1">MTANASELPGQEAAPFSLTMEVEEDVELEIETFVRFKRRGEYERAEEIFQQTLSAHLSLFPVIAEYADLLLVQEKYRMLSEFLDIQIQYMEPVLEEEEVELLRIMRSLAHLYTEGSLRSALKQAKASWDYMYSRSTKIPFGTLPGDVEIHIFELYIRIMVFALKNSNWVTLDKMKCPWALEESPHCGFVRWYSILSSNGHIWSASQVLVLLLEALPLFSSLDGSVLFDKHCFGEIPSEEALCEFRELDWVIACSVSFSRAQALLDLTLILYPNNDKWRGIFEVALGYHQAAKFLTTITSRHDMRSLPCFKCYVQGIQFERVQETLINQGPDYQGSSINLASLLDLQLRDHGNLIGFIQSFDLCATLIRTFIVGHCAQVMKTDLSSTADSFLPVSHPMKWMTQIWDLIQVLEGRFRDSLQNIISGKKSAFGQFADLRLLVPGSFDIPAYIRAVHTIQKTLAVQPCESRQELLLSNSYFEEKIKVLLEPVSMISLSELVELADLVLVKTRKSIGADESATEIKQIATDQAGKLSHDPSFTRKSPTPNIDAAMEAGAKHGGALAESSIKASSQLPGEAFSNLQNSIQSPLTGNYSARDQTQKTAKESANDEVSISYIEFCKGLRADLKKCFEQCDRTTPKFAPRGTAETLLRGLKLLQFFNCLSLPEVAIQALDPPYEETLARRLSEKRLHDFLAILIYSECEIEAVQHFVINLLVRESWAAERCSLPTSGETLMELFEDTIATDKFLTQQAIFCPAVLVVGMEVLIPNVEGRRLPYVKEQIIGKGSFGTVFKTAIAEGHIHDPYFNDFTRWTTQVARKDFNIRTDLESRRSTAAHEIMTTILSLRKENDNVLTSLGAFCIGSLTYSLFMPLATYNLGQYMMVSQPMRPDSRNQRVAFIKNAQGLANGLDFLHTRLKTKEGDDLVCYHVDLKPENILLIFSEKTPGDDICTWKISDFAMSYVKYRRQGEEQGTVIDLRSRFTRNLEQNSQDSPASRAEGRLGEATCLAPECMETFPIISTSSDVWSLGCVISIVFTYLDDGAQGVTKYAAKRAAHSKANGCDRFFIRGRNNPRPHPAIKTWHSQLIKRAKNRSRGEGKEVELILRFLENDVFQEQSKRCDARSLEQKLSKALGTYEELELSIDQGRHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD69</accession>
    <name>A0A1Q5TD69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD69"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="512"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="707" mass="80005" checksum="C397EF45B73D66BB" modified="2017-04-12" version="1">MILSILRLKWIPYHILFWYVAGIIDLWVGGWSTTHGWFPRGIWNINTGFLILGCAQLCQCDTGWVIGRCHFENHVLDIIAQFMKNYVSRIQVDTVPYVPRRPPVGASPSPSPLTNGADRPPSHTEDLALLVSDDEAECDDLPLINDIQSRSKDPAAVIFFVRSSRAWKEGKVPPTEAWLLGFCAQLQARWTAEFGEFLGPIQHITAVQSAVLPLRPKYDQLFSDFLNSVEGRRVELVVSGRDGFLTDERNFSAFLHKFRGKHWSLTVYRTGYDTFLHIDLRQLLAHWEQPMASPAAPRSVIGFAGDLRQASERRLEMGQAGRRLKALEPGGRNKIRGKEGNADLDVEERGPVSLKTSSTFHIVECQHCPREFPSVGAYQSHQDRVHGVDFSAPPTFREISRQKKCGRQPPNPTSSLQRVFLCVDCPEDGRDQFLTYTSWQSHRRNRHQGGGSSDPLIQMVWNDDLFVLPFECVVCGMDFGSRENALKHHRLNHSGRSDSDDQYQVCLENHKFKCPVEGCDWTFLRYSSYIYHASKSHPGSPPEEPEYREYQGKLPPNDPYDILDTECSPLRSSSPSSHSSLSHRETPARFEISPTDENRPCLPILMDLEDGPLDHQDWGGLDEIPETSDAFLSPSADDVLMAPLPQHPPVSDEVPMTPLLRFTVSECPSPPNISRYHPYLDPLIDDVTVYPISDPLQGIMSYFVCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDK3</accession>
    <name>A0A1Q5TDK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 36-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDK3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDK3"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28886" checksum="EF2F1BC54F323E29" modified="2017-04-12" version="1">METITQARPSLTNNDAAVLQALFDAESSPSSGVKVDPTLPSWPAAVNISQTDLTTLKTRETQIILNLQATSTPTEETVQTALKELNTLLEEYPTYPPAYTNRAQTLRLLADLEYNNHTTHSAKTESEPESITDESLFTPEASDLSSKIFADLGKAITLATPVSPADPISSVQARLLADAHTHRGYLLLKAARVKKTRPGVEVDSVGPERLRGHSADQLEEMASRDFFLGGRYGNKVAQQMAVQTNPYAKMCGAIVKEAMRKEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDQ1</accession>
    <name>A0A1Q5TDQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDQ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="169" mass="18991" checksum="23D7894173B8CFA7" modified="2017-04-12" version="1">MNRHGIIVMATQTRNNKIGQRKPGRGRDSGGAGMPEARAHMRWHPDRARSRHVGRDKKTVSARGQQGQGLLYDENIKIKRHIREPHRQAKGIHSLPETLSWVDRSVAPLAMVLGYHSRQGRRIGMRSQGIVDAWGCFGLWPVNSLTSMVGPFGQISGLLGYYRLYCDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE13</accession>
    <name>A0A1Q5TE13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TE13"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF41">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="153"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1300" mass="143771" checksum="FC9AD59D40ED037D" modified="2017-04-12" version="1">MAELIINKKERRKSLSVFSPSSSAVTPLRPPLHDRTPSDDFPAREKKARRNSGFFGRSQSPNRWASGGNVLRRPGTAGSDTAALSAAMSAPAPPLETARPRPKSLQKKRNSVFGSLKSMHAGEDDVLLSASIAAMGDEPQSATSPRNGIWSSAILHYGEIQTMGGMWKRKSQYLVLTDTHLVRFKNQAKAADAFPSIPHSYNGRTPASHRQSVASISSMQDMQLMVSTEASAGIPLNSIIAVYMLEDGRLSPTVEVAYLDERTHKAALIQMQTADLQELNLWMVGIRQAAQMARSNDPLPFDRGSVEYVTRMLEHERDYDPVAFRMFRVIQIASSKSPTRSSSDDLTKLSPTGCYLAIGLHKVHLVPMQKAAHRSSVVSLSDLETGASFGLMNLTGLSMEYGDDSLHLTFRVPLRKSFNVFLASVHSVEVACWIRQHTEFLRPLWTRQPYDFVVPRELQNDENFPPVTLDEDYGCFDRTLVAYSASYDVDTSNIRYTIDLECEDAPCFRLLRPASTTNSRYSALELIAVMRALRYNESFRSISFRGINLDALQGLRDVHGVDVDVHLDRSGCLVHIPGQANLTVLSQEVRALALKSKWLRRLDFAYCLTRTPTLDKGSRDPGCGIPEAIFPVCRRELTSVDWVVLNGIKLGESDLDYLVDAASQKRSHLRALEVGDCGLSVHDLDLVLSTLVAQENTLEVINISGVQGRLSPDVLQQYIGYFGQIRKINLSRISRTSGTEPLITAEMLFNWELEELVLSRTAVNRETVDSIATYLASDRSRNLRMLRLDQCGLSGEDVAMFMHSMSLAPDSPRSLHLHVNENRLDNGCSFLFDAIGKNMTPSHLSMQMIDFKKEEHFRLLVDSLRKNRTLRYLDISKASLPYDAGPETCRMLQLMFEENETLEALDISGESAHLDVARFGIGLNLALTGLKKNKSLKVLRIEHQKLGLQGANTLASVLEENNSLREVHCENNDINLQSFTVLVNGLQCNRTLLSLSCMDRDRVLSLDKVRREVDNVRLDTSNVQPSTATSIRRSLHAAMGVRSGTASNRLSKHMPANVPVSPSPESVPFVSQNVDLVLQSLQHKWDVEVSRLQRYLLRNYNIANGIEDETIDDSASDGRPATAASLGTMLENLKFEVAVSADEIHASPPDTTSSPQLSRTTTLDTQPVQINIEPKTNRKTSSSNLRLQTSRASQILPPEYGSSSPSAARLAVPVPAVPAAVTKANSVRSARSSSTVSTGTGSGRSTYGMASSTLRGFLTGSALKDKRRVDAMRPVCVSTSNDKPPQLDWAPPKLDLQELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEG7</accession>
    <name>A0A1Q5TEG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAGA-associated factor 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEG7"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="199"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="398" mass="42596" checksum="6CAC8C555C96EDA7" modified="2017-04-12" version="1">MATNGDAGRASGSLVDASGYKFTEKDTKPGKMKVKKTAKASTKKKADDSKDGPVDSSPTSSPLPKLDDKVAASFPTGKPREEDLLETVICKHCKRPILKSTATEHIRGCLKAKQEKARKKKEARDAANRAKNADGKDDDDLRDKIDGDDAMKGQKSAKKSAVKGTVDDSTKKGKKRKADEDDNKEPKKKKKKDEPKAKAAKPKGPVDVEKQCGVTLPNGAQCARSLTCKSHSMGAKRAVPGRSLPYDMLLQQYQKKNQAKQQRAAIDANAPLPEDVETNGPVDSDEERDTVMAAIARSAPRPLAENTLITTKSKYRIVRIKEQMLHAMGGRGGAGLFSTDDSQPLFGGNLFQPFDPDMNSSSSPVLPAGEVGDNSVGGDGSRKTPVQGSRKTPVAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFF6</accession>
    <name>A0A1Q5TFF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="9152" checksum="D214B6D8657D6751" modified="2017-04-12" version="1">MAVSLDLGKLIHDSKPDGHLITNLKVARMTPEYVTRKDLENLKADIETYLGKIRFLTVHIIDILAQKIKDLQAEIRSREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFI7</accession>
    <name>A0A1Q5TFI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plasma membrane proteolipid 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFI7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFI7"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF116">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="57" mass="6322" checksum="7F6240706C8404AC" modified="2017-04-12" version="1">MPFTASDICKIIFAIILPPLGVFLERGCGSDLLINICLTILGWIPGIIHAIYIIFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG33</accession>
    <name>A0A1Q5TG33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG33"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="59601" checksum="3B890EE0D2075DF4" modified="2017-04-12" version="1">MKDVEKASDEHIEVYDDTTRDNGLDGSTKVMGTVKLTEDSIVYIPTPTADPQDPMNMQIWQKLVVLTVISTFSTLSVSLVSGFGGVITFYVPEYSAAGKDYAAISQLMTYPTLFMGIGNLIGMPVAIAVGRRIVLLIFTLILILAAVLCAKAENYEWHLGARMVLGLCAGQSEALVPMITQEIFFLHERSKYLMVQQAIQVVLTTIWTLFASPIAGGITPQGWYGLGAGLAGLQFLVAVVLLPETKYDRGLTAYQETGSDENSTAQMDLENDGPVKPNIMVCKERPPLDFVNYEPRTWKSDMRLWVGKPEWHKAVDVLKQTFQLLLFPNVFWALCINGLTIGVNIAIATTYGTILTSAPYHWPNSSTSYVNCGQIIVALIALPLLGTGSDTIIKWFARRNGGMHEPETRIIPLVIPVIVGVFTAVLYGQGAAHPEQYHWFVYAWAVAAYYFCFVGANIVAITYLLDSYPARAGPLLVIICAFRGFISFGTSYGTTAFVESNGYDGAFGAFGALTGVLGLLGVPIYFWGKNIRKFTGRFAKSKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGE6</accession>
    <name>A0A1Q5TGE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGE6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGE6"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="521" mass="53994" checksum="A843250FB4D1A4CB" modified="2017-04-12" version="1">MAHHGHRHDRISRLIRAKHRLEASEENPVDSNLLTGVETLQDPIFASDILSGDKECDPLQNTTCDDSPDATVVVLSKRQEAQTPTTTVVETVVQVVDTNSQTLWQSSGVDFPMTITDSAFGTLVLTGSSAASTDSVIPSSNATATQSMSSQSTETLAPTSKQLAAISSPRASAAISSVPYTSTRLIPSSSATTTSWPTSTSLHAAGNYYSSISSSSASTNPYTDAAYSSYTPVSTSSGSGGADETGFGTGSGSGSGSGSAPTTSQAQSSSGSGSGIDPTTSKIVGGVVGSVAGLAMIFLVLFYLFRRRKLLLQQKETGALPLPSDDGGTTREVTTRSSNEPLFSASYLAPAFMKRWRQSTMTVRSESTVSSSNPSERGFQKISGRKIPPVLTHGGDGYGGGIDGDSPTIPGFPPMSPAGGATTSPSSQAPPPTSPYGMVLDTKYTQEAEERAESPVRPSPVHLPISSSVNVGVATTVTPSTPIAQPQSAIAVMPQRPDGLGRSLPSYDGSRSSRFTESIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH83</accession>
    <name>A0A1Q5TH83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific phospholipase C6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH83"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH83"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010323061" evidence="2">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="471" mass="53323" checksum="A6D3E300AE2C0D79" modified="2017-04-12" version="1">MKSALKIAAVSGLITAASALPPAPSPPNTQSWSKLRENIKHVIYLTLENHSFDNIAGYWDFHPDINNLRKIDYCNEYTNANWTVWGEPLDICAGPFETEVPLVDPDHNFAGVTYEIFRKWNITKDDVPNMGGFVERQSEKYKSTPGDAAFVIKAYDQKKTALLAELAQNFAFFDAYFAEHPGPTNPNRQFATSGSSCGFVDNTDQSAGFWNNVTGTTCATSIFESLSNKNISWKNYYETDIIDAFMYKWVQDNAMDHLAHADEFYRDLEQGTLPTFSYINPECCTIDSMHPTSPMASGEQMVKHLYDALRRSKYWDNALLIINFDEHGGFADHVPTPLNVPQPEDNITFTGTSEGHQVSYDFTRLGVRVPAFLISPWIPANTLIHKEGTSYAKNSEYTHSSVLHFLQELWGLEGLNNRVQWAKTFEYVFSGIRRDNTPKTLTTPTWEGGSGQPEPKSFYLLNQDYSYYAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THH7</accession>
    <name>A0A1Q5THH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THH7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="53743" checksum="75CE72AA4DC7C563" modified="2017-04-12" version="1">MDVEQSAGMFSAAEAAEVGKKKQSDRFFDEDRSVGHGENDLLGGEKVDAVLAAKMILVNDAIDEIGFTPHHWKLFCLNGFGYAVDSLILLIQSIISVQAQKEFHPGYSTGLTIAVYVGMLVGAIFWGFSADIIGRRFAFNVSLFVSSVFTVVAGASPSWVTLGLFVCLSAFGAGGNLVLDTTVFLEYLPSRDQWLLTLMAAWWGLGQLIAGLFAWGFLPNFSCEDDTNCTRANNQGWRYIWYTSGAFVFVLSVLRITIIRLEETPKFLLAEGKDADAVRVLQNIATKYKRPCSLTVERLEACGMSQTRSTTATGLSQRLISPKEVLHHLHGLYATRKMGWSTTLVWFSWLLIGLAYPLYNVFLPSYLATRGAKFGESSQYITWRNYAINNTCSIFGPVLAGFMCRSRWFWGRRGTMIIGALVTMVFFFCYTQVRTASQNLGFTCAISFCLNIYYGTLYAYTPEVWSLHFHLRLRIIFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI53</accession>
    <name>A0A1Q5TI53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cargo-transport protein ypp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI53"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI53"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1176" mass="129332" checksum="D8B8C445F9431371" modified="2017-04-12" version="1">MAGGNAEKGQRYIASLDQARAQGKWDEVPELIRKVTKHAPHRTCVIQTATAESRVVAYLQQKTSSDSVSTPNLPELIPALLTTIENNDGTPEEIVQAQVCLGWIHWALSEPALAAGRLPKDFATTVDELAAGGQIPSAWTEVCLVKGCYIKGAAQATVSGIDETLETFASLMPWLSGGRLGSPNAQFLSWTETLLCKGAIMASEEARNSSPYSDPRHVEIALRLFRLWAALPAVKQGLTASQPSHLDASTSLSRTSIWKAYYGFLTTVLQNGLAYMAPNDGPDRPQLASELRRIEAICENNLLREVKFPTASSSNSEVEEWVEQVIGNWEVLCGPHWQDQDLGEGGQNTVGRNVLDILYRAATKTYHSHLILRRLFHVHSALADFDLAFQALDSYIEIITGAKERAEKGAEYGELEKDEIFLQTLSEGVTLLSCLGSFDEAEKAKDLTELIRKQLDKQGATVPEGKANGKLLLTQGPGSTISSEIPPAVLATAYRAVGVGLANWASFTPQNEARDEIRGEAVDYLLKSVSPSLGKQMSYSSLYTLSLVLAENRDLDTAIDYVKSALTSHGCSDTSEDLSRERDLVPMWHLLALLLSAKNEFDIAERSCEAAFEQFPPEVFGKTHLDKRSERRSSRHSSHSKERDSGFKRSLVSRLQGREKERILQTRITQLAFVEVMEGSEAAVNQSGQLLSLFATLFSELNLDSDGTKPKTEHLVPPKSSAGTARSFRGSIFSRNRSSHLPDRRADPSMSSVPAVPPLPNGNTTGAEAPAIQITDEDRPGHQSPSSLGRSDSKRLKKRSSSFHRHERPRIEEPPLPNGTESPETVGIAVSGNSSPNATSHPASGRQPLPPIAHNVNHRQQPAPAGHEHNPPVQDTRLPPPHRFDSPTLATTKFSYAQSQKHALGLLVKIWLIIAGLYRRASLFDDAREACQEAFKQTSRVETLTASFESSARAFSKRGWDNAKSSEELWADVYAEQGLLAQSQSSPHQAMKHFEDALLHCPDHPTATIALANLLLDVWDQKLPLELSNADVDLNISRLSLLSNLPKPKVANAISIDELKGPDVETLPKAEASSSPHDVDPKHLHRLAARDRAYGLLSSLTKLGSSWDNSEAWYALSRAYEAGDQIDKLKDVLWWCVELEDRRPIRHWSNIGSGFPTEAVRDWEEKERKRKTSQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJP0</accession>
    <name>A0A1Q5TJP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27554" checksum="A2557C0F150087EB" modified="2017-04-12" version="1">MHNILQSRIPKGTPITATPTPFRAHLLEVMGVMDIPCLAIGRQTPSIGIWRRFCQPTGPRHGIEPVTGIPRSLLDLLAGIGLDTTEQSFWDWPGEAGNFLQCYLWEAYRLAGILSIRQWERLHKPFSDSPQNLSTWRQPNSCPADSSTLVSRVLASVDALRMGCLERPNEDPFIKNSILFPLVVAGLEADIMCKNPQWQQTIRRSSLGSRQDHILLGILEEVWHRGDSTLDINALARGKDIEMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJR4</accession>
    <name>A0A1Q5TJR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_7920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJR4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP00463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="59513" checksum="1DA2007C63E807F8" modified="2017-04-12" version="1">MATEKPATVGIDHVEVVANTAEDARLATEEEHRLTILEALQKHYKACLWSMAVSLTVVMDGYDGALLGSLSAFPSFRSQFGTYVNAKSGYQLDAHWQLALGCSSPLGNIVGIYLGAYTVDRLGYKRSALIWLTWLTGCIFISFFATHISVIFAGEVLCGISWGVFACLAPPYAAELCPVVLRGLIEIWVVMCWGIGQLLSYSVLLTLNHRKDEWGWRIPFAVQWVWPAIIVPLIFFAPESPWWLVRHSRREDAEKVLKRLASGGVTDEQIRRSVALMVETNRLEANMHEGVGYLDCFRGTNLWRTEIACAAWAAQLWSGFVIASYSTYFFELAGLASQDAYKMSVGQGGLHLLFNLISIAFVANFGRRRLYLCGLAFMSLIMFMLGFVALAPETPAVGYASSALFLVWNCGYQLTVGPSAYVLVSEVSSTRLRAKTVALARNAYNLSLLVNYFVGPYILNPTKGNWKGKTGFLTGGIIIFFWIWAWFRLPETKNRTFEELDILFSKKELKARDFKSYEVVEADIHHVKLGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKI9</accession>
    <name>A0A1Q5TKI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKI9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKI9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7601" checksum="1AE598AECE1CE45A" modified="2017-04-12" version="1">MQLGGGFCSGDLTSEAEWCMTVRNKIGIIVVDVDYRLYPEFAFGKGAEDAWAALQWVLMMFVSCTGQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL70</accession>
    <name>A0A1Q5TL70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo-beta-1,2-glucanase SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL70"/>
    <dbReference type="OrthoDB" id="9981847at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24165">
        <property type="entry name" value="TfSGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058773">
        <property type="entry name" value="SGL_GH162"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26157">
        <property type="entry name" value="SGL_GH162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270853" description="Endo-beta-1,2-glucanase SGL domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,2-glucanase SGL" evidence="2">
        <location>
            <begin position="73"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="58241" checksum="D3A48D33DEB8BA04" modified="2017-04-12" version="1">MRFCQASLGLACATLATALPAASEQGGEPTCRFAQQYTQKQILQDPTNFINDMLYWEGKFHQNNVSYNSDNGMSYDGTNIDFVTGERTVKHPFSAASKESLQVMLYAHAISGSAEAARFLSPSNPSAAPGIAASIMDLKLQTYLRFNETYPGFGGFLPWFTSSSQDLSPTWDWNNRVPGLDNGELLWAVYAFIQAAENTSNKSYIDLAKKWQTWMDYTGTTAAHIFYQGAGKVCAVVDIKNQTLPVHHPEQTYACEGTDSYLDDPFEGELFTWWLQFFGGLSDTDIEALWEYKRAKLVSVDYHMGYIGPITVQKGYWFSSHETWKVMEMPYYDIDIIRRVFQNAERVRTCNSVVTKVPGMFASVNNITDPSTGDVVGYISNAGIPSIGSQTVQELDVITPYSVFPTILFNKGVGMAWWRNMAIAKKMQNIYGSTESTRRDGAGVSALLTWDSKVTTVNAILGGVSDLVRQKMKAENIYNPFVNRIEAEYSRVFKNLKGEHVAFCLPQETVPDSGLVDFTTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMB2</accession>
    <name>A0A1Q5TMB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyadenylate-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMB2"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP01332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="20410" checksum="330DDA56DD97BBF7" modified="2017-04-12" version="1">MATESTELKPEQIPPHDEGVDDEEEIAAMKRRVAEMESEAAKLRDMQETLDQQTEGLQENKEDIDARSIFVGNVDYGASPEEIQAHFQSCGSINRVTILLDKFSGQPKGYAYVEFAEPSLVAQALVLNESVFRGRNLKVTPKRTNVPGMTRGRGRGGFRGGRGRGGPRGSYRGGYRGRGRGFAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQJ1</accession>
    <name>A0A1Q5TQJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQJ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQJ1"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="70"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="521" mass="56309" checksum="8ED4C982DF6CBEEA" modified="2017-04-12" version="1">MQSVPDGVLRVKQTDRAIINLIAMPDGVETPNGLGTPPNEPASGFEIVTWNGADDPENPQNWPLQTKLLRSSSPLTVIFAIAFASSVFGAAADVTAAEYGVSQEVMSLGVALFIAGFATGPLVFAPMAEVVGNAPVLAVALAGCALFQIPLALAQSVVTILVCRFLAGMLGSGGLAVGSGILADIYGPITRGVAVGISASIMNIGSIIAPIAGAYIVDRYGWRWTAWVTLILCGVVGIHAALLLRESSHNRILMRRAARLRRETGNMNLRARAEMASLEPQVLLRKYCTKPVRMFIQEPILIVMTIYLTLVYGTLYLSYQLFPKAFQNRGWSKSTATLPFISVGLGVLSALGLFSLFTMTWYKKRWLASQKTKEEEGGKSSTQITPEHRLPPMILGAGILPPALLWFGWSGDVHWASQLIACFFIGMALQVIFISGIVYIVDTYLLNTVSAISIHVMVRSLVSAVFPIIEGPMYETLHINWSATLLAGLSAVIMVSPIVFMIYGSRIRSWSRFSVGDNQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRR3</accession>
    <name>A0A1Q5TRR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fluconazole resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRR3"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="302" mass="33744" checksum="A5FC391F877C36D7" modified="2017-04-12" version="1">MAARQSTPSSDHSHSDGVRKRVCKACDRCRLKKSKCDGSSPCSRCRADNAICVFGERKKAHDKVYPKGYVEMLEQQQVWLVHGLQELYRRSTEGEGWPGDLLKPEPNGHPLTHDLLTRLGALDHSKGERFEENPEVMQHDLWRNGMTRQDSTDGSTDSPHSPVARSRFSSDAFSSHSQQTMPPTPPTYSPSSRTAPMQQQIKVEPTMSTAPTPQSQYALSMQGVVNPLALQGAPQWPGNNGGFNPFDEMDLMGSADYTNFNFEDPIPSPMFHRQMPMNCVPSGDYDDFKEFLNPNPTEITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU62</accession>
    <name>A0A1Q5TU62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="442" mass="49159" checksum="961D9AFAE1F8BA0E" modified="2017-04-12" version="1">MAEPAQPKNTTGLSHPLHGVLAELRRRPYPHVPNPPGCKKRASVALILRVKPTYDHWPGSDTIANDTSLPIEQQLQNFFAQPWVERGDPEVLFIKRASREGDRWTGHVALPGGKRDPEDEDDRAAAVREASEEIGFDLTTDDVISVGNLPERVVTTSWGSVPLMVLCPFVFLTTRNDCPTLKLQPTEVASTHWIPLRALLSPSLRTVEYVDISQRFAGQYGYMARLAVRSLMGWMQFAAVRLLSSETQQCTSVPGFVPDDTTKQKSLISRFKAWTLSNQAESGDLNRPLLLWGLTLGVLADFLDMLPPHTAVELWKYPTFTAPDLRLIVSILTYNLRKRNSREVKMGARPTDTAADSETAALPVTPGADDHDHNEVGIGGLGVGRYYGPADRTADGTSYAVGIMLRGYYQRLRVAIWVFLAWRAALGSAAAFTAWRFLRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U097</accession>
    <name>A0A1Q5U097_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U097"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="91" mass="10114" checksum="1F63270E8656A28D" modified="2017-04-12" version="1">MTRLKGPNARTKTVKTKTTTTRHGPATTTRHGPATTTRHAPATHRTTKRRWGRTQPQHHHKRKVTMGDKVSGAMMKLKGTLTGRPGVKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1T2</accession>
    <name>A0A1Q5U1T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aflatoxin B1 aldehyde reductase member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1T2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1T2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="39711" checksum="3AD9DD4C34B14199" modified="2017-04-12" version="1">MPLIAQNPQPRVILGLMTFGPTESKGARITSLDEYNKCLDYFQQQGFNEVDTARIYVGGEQEAFTAKANWKERGLTLATKWYPQKAGDHKPSVVREKLELSLKELNTNQVDIFYLHAADRSVPFAETLEMVNELHKEGKFVQFGLSNYTAFEVAEIVITCTERGWVRPTIFQAMYNAITRNIETELVPVCRRYGLDIVIYNPLAGGLFSGKIKSKDAPAEGRFSDKSGTGNNYRSRYFRDANFEALSMIEPVVEKHGLTLIETALRWVRHHSTLKMDDGGRDGILVGISSYGQLETNLKDLQKGPLPEEVVEALDQAWMVAKPYAPNYWHLDLKYTYDTKEALFKPKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U206</accession>
    <name>A0A1Q5U206_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lymphoid-specific helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_6506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U206"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U206"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47161:SF1">
        <property type="entry name" value="LYMPHOID-SPECIFIC HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="240"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="656"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP06516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="888" mass="100435" checksum="C0F7C392D8C32763" modified="2017-04-12" version="1">MSAVDSPITPTDSRSGTTQPESTVPSSPMTEPTDQGQKEYSEKELDTNNREYGEKDTDAPNGDSAGATEAAEDTEGMDVKAKALMHLLKTSSVFVAIMSEKMKKQQEEARQRAAHQKRDTTEPKANPKSAASARRETRNKVKDEPAAEETLNEPAAGRRRGRPRKSGANGSTISSYFQKADVKVDEDNPTVQEALEQAAEDYEANPTALGGQELVATQQPSLVTGGRMRTYQLEGLEWMKTLWMNGLCGILADEMGLGKTVQAISMLAFLKENNVSGPYLIAAPLSTLSNWIDEFKRWTPDIETVLYHGTKEERAAIRNKCMKTRDQGKMNFPIICTSYDICINDSKFLGQYQWRYIVVDEGHRLKNMNCKLIKELMTYNSANRLLITGTPLQNNISELWSLLHFLLPEVFNDLKSFEGWFDFSSVLDDSGKAEVIERRKRNLVTTMHSILKPFLLRRVKTDVEHSLPKKREYILYAPLTPEQKELYREILSGTGRQYLEGKALERLTAKSYTTTRSRSLKRRRSSDEPETPNKSQRTARDSMPASGTASARRRRGPQSYKDISDREFNSKLRKLEQGVEEDEEEIDEPIDTELEEIERANNLKLAKKEISQKKMMNPIMQARLACNSPHNFYWPWMDENSTVDETLVSASGKMLLLDRLVPYLFKKGHKILIFSQFKTQLDILQDWATQLRNWPCCRIDGAIAQADRQAQIKAFNTDKTHKIFLLSTRAGGQGINLVAADTVILFDSDWNPQQDLQAQDRAHRIGQTKPVIIYRLATKGTVEQTLLEKADSKRRLERLVIQKGKFRSLLDTGSAHDVEELRKVLGEDEFERFETGADPASILSDEDLKILTDRSEEAYARAEKGLEKSGPAFVSVETKRDAGESLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U782</accession>
    <name>A0A1Q5U782_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhamnogalacturonan endolyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U782"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U782"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000017">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000020">
        <property type="entry name" value="Rhamnogalacturonate lyase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012931313" description="Rhamnogalacturonan endolyase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="7">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP08330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="41568" checksum="FC7B31417006F4D4" modified="2017-04-12" version="1">MFISALLVASLALWGKGVEAAFGLTTNSGTYVVDAGSANPLKFTVDRTSCDITSINFYGSELQYQSTGSHIGSGLGTATVTATQSGDYIKITCETSTLTHYYVAHSGDPIIYMATYTTAEPSVGELRYIARLNADLLPNEEPFGTASNIAGGTAIEGSDVYLVGSETRSKFYSSERFIDDQRHCVSGSAHRVCMILNQYETSAGGPFHRDINTNNVGSYTGLYWYMNSGHVQTESYRQGLHGPYLMYFSRSGTPSTSIDTSFFANLGIKGYVATSGRGYVSGTASGADSSLKWVIHWYNNAAQYWTYTSSSGSFTSPAMKPGTYTMVYYQGEYPVATSSVTVTAGSTTSKSISGSVKTGTTIFKIGTWDGQYDLLPSHASPPQFPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U810</accession>
    <name>A0A1Q5U810_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_5590</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U810"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U810"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="10328" checksum="D0A9AA823D7E808E" modified="2017-04-12" version="1">MENGASSEGKDPSAFLSEIIGAPVIVKLNSGVVYKGIFIMGALFVSGLANCSVGELQSVDGYMNIALEKTEEFVNGKHRRSYGDAFVRGNNVPFAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8U0</accession>
    <name>A0A1Q5U8U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000563">
        <property type="protein sequence ID" value="OKP08901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8U0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14982" checksum="D5C1DCE82BD25F33" modified="2017-04-12" version="1" fragment="single">YTAVQDYALSNGVWKYTNPNKQPATPPQEPIKPQISDVVKRPSNTFISDEPSPTRLIDLIPDQLSIYKILLSEYESSKSDYLRYMRAIELLKQGIRSSLTPEGRQIVNGLSPREAIIKLRTTFALSSQSKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA36</accession>
    <name>A0A1Q5UA36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000544">
        <property type="protein sequence ID" value="OKP09331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA36"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA36"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008402">
        <property type="entry name" value="APC_su15/mnd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05841">
        <property type="entry name" value="Apc15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="29355" checksum="4C48A6F32375E86E" modified="2017-04-12" version="1">MATILFTTIPDLHFSFGMPPSSLSDLTRVRADERLWKAHKRHIASFGRSWIKSAGCAKTARLEEEQTAHREVEHDALAGLMDNFRIPEQPDNALMMELDLDHDIPGSDFEALYLKQERRGEDHWDDGLGFGGEPFSADVSDFGSVPWYSPVHLSHVVGDGLEEAMGYQRAHRRQDNASGETEDYMWVDRPRFPDILLTSTPLIPAMTGGRGIVSEMQRSFVQRLRSQDNGLDDGTPALGGDFDGMGQSVQHRRADRMTMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAN0</accession>
    <name>A0A1Q5UAN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000503">
        <property type="protein sequence ID" value="OKP09535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAN0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="25424" checksum="52A8EE374A4E1740" modified="2017-04-12" version="1" fragment="single">MADPPAGGPEPPPTNAQRGTAIFTRENFEPSIVPRKRRSPRHGDEITTIARSNPEFANTEDSTGRVTTKEIRQLISSLKEVIAYQTTVIESTKAELLEVKHDQNVLRDQNEKLYDEIRTLRERIETLTPVTEARSWAAVAASGSISSPQSNHQRPEKERDCVRISTQRSFVDPSDNDNTDGNTFGRYLPTDAANTYIRTALLNAPSTQDAQVAGVGTTKTGYVIRFKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAW3</accession>
    <name>A0A1Q5UAW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nudix hydrolase 14, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAW3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAW3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000068">
        <property type="entry name" value="NUDIX family hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="278" mass="30187" checksum="FFE45A8D6015E26B" modified="2017-04-12" version="1">MSISTFTLPGLNLRVNSTADLARDELSSFPAFKTWLSTLQKSLARQSNPSHEFYDDPYVLRQIDIQAVDRFGGGRLGFVKLKADVSNGRGEKLPGSVFLRGGSVGMLLILQPDDIPSSQDKGKQAILTIQPRIPAGSLAFAEIPAGMLDDSGTFAGGAAKEIEEETGLEVQHSELIDMTALASELTEGSPENGEALQEAMYPSAGGSDEFIPLFLCQKRMPRRDIEELQGKLTGLRDHGEKITLKVVPLEDLWKEGLRDGKTLAAWALYKGLKEAGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB56</accession>
    <name>A0A1Q5UB56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB56"/>
    <dbReference type="OrthoDB" id="5381672at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="763" mass="84876" checksum="C718B3BBDDF9137B" modified="2017-04-12" version="1">MAENDSAIHLRSLSQPSLVSAPDSSTQDETPRHSSRHLPDDSTPEHGQHEELPAYSRAPPTNQSLGLGHSTTLHRSGLIALITVLFTALAVYAWVILAILSFRPISTSSWEENASYANRHYIHHDWAFDTRLYRSARVIQSILTVIILPWTSAVCAHAAVIFMQHQKDSMGLTMRQVMALADRRWLDFSLLSDILRGAWKKHGSLLLLLAIILHFLGAIIYPIQAIVVNPKTIHVPVSINEMGTVGDLAHQAAYYSTVTGNDVVRTRAALLNADSHTMQPQLWQGIQGQQLSNFKNFSTLRDPFYAPIPNGFHTGVLQQFALRINSSATSRSIAAAEFPSGCNSNSSGFFANYSSLLLYESIPYYWAIAACMPNVTSKSPWVETRDRQEFSESLYLNISIRDSNVQTTALSAGSALYEITLRTTAGYFELPNFMNNGTPGALLESDPTPNCNKTCIRQINQYSYYNRARRDETIGNTTNYIHQTVPWASLEVENKGPLLTTALALFGPGSFLDTFFASMKVIQNNLPDSNPEYGYASSSKVCIELGPLMNFFHTVYTPRDTCISIYMNPNSNVNNAHDLVRDWLVSMYQSASSFPNVFTTAAFLSNKQWVESMKPVYAIYQDPGTEMEIPDIGLAGVIVVSILLGPYLLLLLALSWYGSRAPRWTYRLDSFAMLRFGAALGEGIFPMLIAERTNDIKELDEIPGVIRDVGPVSEDAIIPVNRIGLWGGKPLQNRRRYECYEADNEAMTLVEVNGIRRGGVSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB60</accession>
    <name>A0A1Q5UB60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB60"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="367" mass="39622" checksum="3059E9D5DEBE690A" modified="2017-04-12" version="1">MFNRPVARSAVKALRATTRPATHSTFTRPLSYTIARANKKNDPKNDPILSATTKAPEGASGEHEGQFARTDENVQIEYPPDSEMPAQPVVQGRGGMHFKRTLAQFSLESKVSMVTGGARGLGLVMGQGLVASGSDLAIVDLNKAEAEEQAQKLVEQFRKENPGLEEMPNVTAHYADVANPDSVNEALAEVLAKHKRIDNLVTSAGFTENFDAISYPFDRMKKLWGVNVDGTYLFATGVAKHLMERNAPGSIVMIGSMSGSIVNVPQPQAPYNAAKAAVRHLAASLAVEWAGHDIRVNCISPGYMLTALTRKILDENPQLRDKWTSLIPVGKMGTPEDLMGAVTFLLSDASKYITGADLRVDGGYTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBG4</accession>
    <name>A0A1Q5UBG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase SRPK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBG4"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="436" mass="49834" checksum="BC142267279827B8" modified="2017-04-12" version="1">MAASAPPPGKDKGKQPKIDYVPLEGVEDLEYYEKGGYHPVKIGDILHEKYRIVHKLGFGTYGTIWLAVDQTSRQFVAIKVGRAEHSNPLEATSIKGLQHTITFDTSTIRSVIPPLLDNFDIDGPNGKHPCYVTTVGGANLSLAKLKCHQGVFRLDVARAMAAQLVIAVAHVHEKEYVHGDVNLSNVVLRLPFDINKFSVDALYEKFGKPMRVPVVREDSKELTPAVPSECIESVWMGKTSDEIRLSDAKIMLIDFGESYQPSLEARHNSMVPRAYQPPEALHEKDPLLSFPSDIWTVACSLWDIVAWFPLFESYFSKETENITAEQVSVLGKLPPGWWSYWGRKYEIRRRQFDKDCKTKHPEEYPDMETRFDEAAQKPRRARGWEAMADGEKKAFLLMIRSMLKYRPEERATAKKVLESEWMKRWAIPEYDKIREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBT5</accession>
    <name>A0A1Q5UBT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_4654</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBT5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP09942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="471" mass="51002" checksum="58F1CE12863E48AE" modified="2017-04-12" version="1">MAQKLAIQGPISKKNLSLPKEGWDLERIEAELEDLRNLDHTRWEDGRVSGAVYHGGSELLEMQTQAIGKFSVANPIHPDVFPGVRKMEAEIVAMILNAFNGPDDGAGVTTSGGTESIIMACLAAREKAAAERGITSPEITAHAAFFKAANYFKIKLHLVSCPAPEYKASVPEIRRLINRNTVLLVASAPNYPHGIVDDIPRISALATEHGIPLHVDCCLGSLIIAFLKKSGFPSPYEKEGGFDFRQPGVTSISVDTHKYAFAPKGSSVLLYRNRSYRNYQYFLLPDWTGGAYASPSMAGSRPGSLIAGSWATLMRIGEAGYINSCQQIVGAAKKFETTILTNPVLNSHIGIIGHPLASVIAFTSRNNELETYDIADAMDARGWHLNSLQSPPAIHCAFTLPTAEAIDSLISDLIEVITELSLRIEERKESGDQSVHQSGKSAVLYGVGGSIADMNTVSQFAEGFLDTLYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCP0</accession>
    <name>A0A1Q5UCP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4403</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="43653" checksum="3592C0DAB6968640" modified="2017-04-12" version="1">MTTKVESLHGSTPVPGANTNSSEFHSHEKDLESQKSTANQEEATQSTSSQLEESLDPGLDDNSNVPRLPLLRLFWFFFYNFGLFAWGGPVAQISLIKDKLVMQDKWISLPRFQRVFAVYQILPGPEAAELYHSVIDHNTRKTSPYLVIAGLCTALNSALRINVFITRGKRIIALCLFILQYVVYAIYVVFRGVPSPVSLALGIAKTPFLPNLFALGLVAGSLSFGGAYTAIPFVQVEAVLKGGWLPAHIFLDGIAIGNILPAPLVIFATFVGYQGGLADGGVGTAFAGAILTTLGMFFPCFLFTIAGHDLLEKLVRNSFLSDFFDGLCGAVIGVIAIIVLQMLQSSLKMTNGSATADVQSASVVASESASAAVLYVIALAALYKSTNKYTPLVLVIIGAIAGQFLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCR5</accession>
    <name>A0A1Q5UCR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000375">
        <property type="protein sequence ID" value="OKP10253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCR5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="144" mass="17355" checksum="83F1F239490FC11E" modified="2017-04-12" version="1">MTSSASAHPNTKYLKINAVLNPARDWPQKPTTDLEWPSGMHKQLSHVHTFHKTQRTSEGVPSFSARVEHRNTRRSLRDTSFSAYRKYLDEEVMFITYHRQYLSLDWDEVLRRFNQRFTSRRRPGFKGIQSVFYRYRRRQIKNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD60</accession>
    <name>A0A1Q5UD60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000350">
        <property type="protein sequence ID" value="OKP10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD60"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="30208" checksum="FE1F84772FA78BE9" modified="2017-04-12" version="1">MTAFNFSTTGSEVVAALADRVTGKTFAEKPLVVITGASHGGLGAHTALCLAAANPAEIILLGRSEEKVSPVMKEISSISPSTIVRFIKIDLLSCASVRAAAAEINASVSKIDVLVNNAGIMGVKFSLTPENVESQLGANHIGHFLLTNLLVPKLEASGGGARIVNVASAMYQLSPVMFDNYNFSDGKTYNAWEAYGQSKTANILFAVALAEKLEKKGIKSYSLHPGVIHTKGLSEVDQEAWPIVGALFESKKLEMPKEKTIGQGCATTLAAALDPALGGKYTNLGSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDD0</accession>
    <name>A0A1Q5UDD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0676 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDD0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000045">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="363" mass="40468" checksum="D2C4E7157FD6E8E3" modified="2017-04-12" version="1">MNSQTDFTDIVNNFPGLPPFPDDVPTAPLLRLSLGKLLAGDTAELERLFEASVDIGFFYLDLQDSEHGTSLLTDADGLFLVGERLFELSLEEKKKYDFSAQNSYFGYKGQGVAVVDKQGNLDRNEFYNISKDDIMGISDRLPTPEVLHQSRDLTKSFMQGSHAIVNLILNILNDKLSLPKGTLSNLHRLQAVSGDQVRFIKAPPQPVDDRRTALGQHTDFGSVTVLFNRLGGLQVLPPGADAEWVYVRPLPGHAIVNLGDAMVKFTNGLFRSNIHRVAAPPGVQGDSTRYSLVYFARPEDDVMLRRLEGSDLIPPIEGDQVEEEINSKDWIIRRALGRRVDLVKDIDYEKSAGTEQMSRRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE60</accession>
    <name>A0A1Q5UE60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE60"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="380"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="672" mass="74068" checksum="E321D3A06D01A9FE" modified="2017-04-12" version="1">MAELNELFVATFPNGVPKDILTELQSILRIHLITPEELFYKWESYSMKMGEEVKLSMETVRGFKQDVQEALERESRGKIGRQTEKRTTLTATPRAAAGTDVFGMYEDDESKVYANWKRLTKYGNFRLDELTPNTANARTMNGSGSVKRKAEFTSPATPKVGRLEKTGTPAGAKTPSSTANGPAVSFAERPNPGQTLETLNAHLSLPETPMAPFSEARIRPTANTDLKKFGYKPMGMRLSEASEILDDRIDEFAAIFQKHYNSDDLTFGSAATQSTSEIIAVGRIASDSLEGKLNPASLVLETSRRTGAGRRVPLKVDSVPSLSFFPGQIVALRGINPSGDYFTVKEILPIPLLPPAASSAVTLDNINERLESGGSSPLNVMVAAGPYTADDNLDFEPLQELCQKAADSYADAVVLLGPFLDIEHPLLASGDFDLPDIKGLDPDTATMTTVFRHCISAPLARLAQAVPSITILFVPSVRDIMSRHVSWPQEQLPKKDMGLPKQVRMVSNPVTLSFNEIVVGMCSHDVLSELRREEVLHGRPTEGNLLTRLPKYLVEQRHFFPLFPPTARANLPKSGPDTGLATGAMLDLPYMKLGEWWNVRPDILIVPSMLPPFVKVVDSVLVINPGTLSKRRAAGSYAQMAVHPRNMTDEERESKQLDHKLYERSRVDINRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEG9</accession>
    <name>A0A1Q5UEG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEG9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="8322" checksum="CB49FA47AA450B8F" modified="2017-04-12" version="1">MAEVFQNQLRESTDLLYWDCLLNACAVREYCKFEDSSAFEPDSSAALRRGDLFPIHFFIDPFQNNCMVDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UER6</accession>
    <name>A0A1Q5UER6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UER6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01831">
        <property type="entry name" value="Endoglucanase_E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037461">
        <property type="entry name" value="CtCE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="36928" checksum="48E4F4BEFD666103" modified="2017-04-12" version="1">MAFSSPTGMVKYTQVVAVPINNISFDRLGSLDWQFSNVTADATYQFVGNWTELTNEEIHEKKIFEMRVQLAGVATADNGELTVPPRFDKKVEVIGGSLASGQYGTYETLSSWAYLFVAGLGNVEHTITAYPGACLTDKACYGGDVHGMTWYWHQASDPGSRANAFYGNEPENWDVNAEQPADLVLIQMGGNDHRHPNEVPGKDFYHAYVDMIDDIHSAWPHAVVLIISQWGSFVKKGMTHQPTQVYEEEAKRVHEHFKDRGFVYYFDTTGILQYNDINPKNHPTDVGHIKLASHLLQWVRLVLRWNLEPLGEVQHGTLYWNDQQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEZ9</accession>
    <name>A0A1Q5UEZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEZ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEZ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="6984" checksum="7EE5A61A33CAC803" modified="2017-04-12" version="1">MSGMGYQYKSIWDAVRVIVAEEGARGLFKGIGPNLLKVAPSMASSWLSFELTRDFLVGMDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFD0</accession>
    <name>A0A1Q5UFD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFD0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="666" mass="74730" checksum="64DA829011B2F03F" modified="2017-04-12" version="1">MDKLPVEILAKIIDFLTPREKVKLQLVCKQFFDLARDNNLWKLHCYEQSWAALQSNRPAGRTSESLLSNSTTPLSTLGQNSLRDLIQPPAPPSGNGELDEERRPSDIARAAADWDSSAEGEHVDWYSEYIARHGPMSLSWVQQPMRSNGQGRRKQPFEIKGMGLLKDWSSARENKIVAPLDDGTVCIWDLNHSHRVDSQSSKGKILGMSEPGVLMTNRSGRRELSPSKSALEFINLGEGVSVDSFRRRAYLAVGNVLNEVDLETLKIVSQQRYPWSIFALSQETDYSVPLTLATTLSLQIHDARLSATEEEEAISLRCEKNMAPLVPELDIFAHPDSPLLQLQANGQPPTRIRSPDPTARENYAPLFQPGPLSILHPPAPHVNSILLAGRFPSILCYDRRFFPRLQSTVHSGGRLCGLASAPAPRFPVFSDSTYPQSHTVVACGEYNGRGSLELYSLESSSQGFNDDPSKMTSQLTPHYKNRQSAASSKLLSVASHGNRLVYSDSEGNIKWVERNGRAEVRRWNINTFHPQIPFSRSSHTPIPGQPNEESNARGLWPDSNPQNNSSEVARKILPTGGNLTGDELLVWTGERIGRIKFSIPADLDGVVVDDEDEWFMKAEVDEETRAAMRQKHRDEWEKEQRYEDMMRRALERQADEVRWMGTDGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFM6</accession>
    <name>A0A1Q5UFM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFM6"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="49"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="206" mass="23117" checksum="5AB5FE322777B676" modified="2017-04-12" version="1">MVNLFKRMRKLKTILDIRTGTGAAIFPSPTSATKEFPPVTRLHLTYARKIYNGHQGARHFWRNCLPRLKYHNPGVRMTVQQTDDQAAPPALTIYFAERLSSTASAIVGAKNITDKHAPAAESGEKTAVVDLKDLNYKEIWSRVQASTGAEEVPASAEDEAERKRLEAITAKAGKDRERIATMRQAKKDQERMLAEARGEVEKMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFZ0</accession>
    <name>A0A1Q5UFZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory component protein SHR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFZ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFZ0"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="218" mass="23742" checksum="723D91291F9DC9B5" modified="2017-04-12" version="1">MAFKSGSFATFLILCPTCFFLGIIFSMFPYDYPILWSTTPTPEAHFDYFEAHLRFLHASPPLIPRILHIVIFLGLAGLITKLYRPSESNMLFDGASLVLYMCGITVYIANIVKGLRLASAGQYGAELATTPEDKEQILGREDSLKVLAASNTILALVLVGVLVLQAGQWYAERKDAQEYESLAEGKKKDEGEAVAASATASGASSGKPGRQASQRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG45</accession>
    <name>A0A1Q5UG45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG45"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG45"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="22306" checksum="170D9402C9D61B69" modified="2017-04-12" version="1">MLDPEEIQTCSGLEEASSVRNSSCLAGTGSSGSATGLGETGSAGSPSWLGETGTGDMAELCSRPATLSSMPQRPKPKSPLPQLDVKAMGLAAGGKIVQDVLADHNPPTMWNVDTARLINIHILDPVSCESVTHIVPPPISMRIYEAIQAELPFFAVEEQIDNRLDGDDFDHVKSVSKMDEGKGITYEPYLDPNQPAMCSSCERRLCDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGH4</accession>
    <name>A0A1Q5UGH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGH4"/>
    <dbReference type="OrthoDB" id="2439692at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF2">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180243" description="DUF7707 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="2">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="186" mass="18989" checksum="5308633BEBD61A42" modified="2017-04-12" version="1">MLSNLLLVLASTAALVNSQSTSSIDPNSVDIKTRQYWCSAQKSACPLLCLQIASGVPESNNCTAETLTYSCVCSNGISPNASEYSQTLPYFICTEANNQCVNACSDSACQSRCRTANPCGAQNPPRVNVTSTASSSVAATSTAASNVIQTGGATGAAPRGVSVEMSQVYGLCVLVGGVVAGFAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGK0</accession>
    <name>A0A1Q5UGK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine decarboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGK0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGK0"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="55101" checksum="4F73CC949A3B2F00" modified="2017-04-12" version="1">MGPFGAVADDNSWGDLVKLGALFGELNACLANQELIRRPSPEQVVRLMELASPTSMGTGRPVGEVIRDAAEILSFRIAVGHHRFYSCVPSPASPISWLGDTLTTAFNPFGGSLEAGSGVCTIEVALIKWIADRFGFPTFSSGGHFVSGASMANLTALTVARDQLLDFEDQTNGDDRPSNGVAYLSSHAHFCIRKALRIIGLSNRQIRVINSDANFRMDIGHLQRSISDDLAQGRHPFLIIATCGTTNTGSIDPLEEIAQIARSRGMWMHVDAAYGGSVAFSKSHRAKIKGIGLADSIAWDAHKWLFQTHGCGAVLFREKSHPLKSFASSAQYVRDVEHMATEEDQNTMLDPWNYGMELTRPARHMKLWFTLQVLGTDAIDRMISSGFHLAKHLETSLRQLDGWEITSPGSLAILTFRYAPQTRDHITKAETMPGTFDLLNELISKELTARNVAVIFTTRVLDRVCLRMCMINPNQTTADVDIVVNTLDVVSRECHEALCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGU8</accession>
    <name>A0A1Q5UGU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGU8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGU8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23368" checksum="FDE18E6ADCBE25EC" modified="2017-04-12" version="1">MSLLDARTEDLLSTPQPTTLIELLARAHALLLYQIMRLFAGDVRSYATANSLFGTLESTVVALCDSLYFPDPSESTELLPLSMDPIIEFWEWWALQESARRTMLLTFYFIQIYKVLRGDIPVHCDGKLGLSHSWYLSAQLWNSQSAFDFAVAWAEKDHFVVRDLDFTAILENAQPDDVDLFGRMLMVTLLGIDGAKAWFYAKGAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGZ3</accession>
    <name>A0A1Q5UGZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGZ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="8979" checksum="8502AB5F42CC9165" modified="2017-04-12" version="1">MSKTRNGGTTSGIEDFLARISDQITSPASDYVQWWLTKLMIKNGALAVRSIGLLWRFQNSRLQRGSSIWGVVSHDLLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHH6</accession>
    <name>A0A1Q5UHH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHH6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="133" mass="14842" checksum="411DFBDA4A3A448C" modified="2017-04-12" version="1">MEKYMTKAVLYGYELYQSGDKIIPVIARSRNPKAVVEGMLVFNLEESKRNAIFELESGLGHLEVVQAEIGCKPSGKRFIDAAAFLRAGSLDGLIPIKSTFWDPTAFVNSSFYHNIEQSVHRSAEDISGSWFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIF6</accession>
    <name>A0A1Q5UIF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIF6"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="37920" checksum="DDF0F153C5CDBBBF" modified="2017-04-12" version="1">MPVAYNDIGVQYFELIDFTFQNEVTLPTARLAYREFNPTAQKVALIPTCFRGRINTTLNFTTGVLRDYRVIVVALFGNGESSSPSNTENFPSTLDYRDCVRAQHEMITKKFNLTSIDVIIGFSMGGQCTYHWAAMYPEMLRNAVIICSSAKTSLHNYQFLEGPKAALSHSIDYNDVAMRSQGGTPLRGLHAFSRAYSAWLTSAEWFEQRLFEKSGFKNLESWSKAGEEGYEDFHPDNLLIMLGMWQRSDIGLAVGSGSTGIPIEQALQSLSTRILLMPCQTDQYFKWEFNEKDASYLKNGELAVIPSIWGHIGGGGANPEDTEWMDRRIAKFLENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIW1</accession>
    <name>A0A1Q5UIW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIW1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010224974" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="39"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="54998" checksum="D842EC4E83F21FFA" modified="2017-04-12" version="1">MQEFRLTAALVACLTLLPAFTSAFWRLPCRGRTGVARLDPIVDPGEISSHVHAVHGGGNFGMNSNMQTLRESSCTSCAVTQDMSAYWTPALYFMHTNGSAELVEEVGGMLAYYLLYGEDVTAFPNGFRMLAGDPLQRNFTWPVPDPPKSSWSGAQVSQKALRQKALGFNCLDYAGTAEASLYRHFMPNKTFLDANCPDGLRLELMFPSCWNGKDVDSDDHKSHVAYPDLVITGTCPEGYETRLVSLFYETIWNTYAFKDVDGYFALANGDPTGYGYHGDFMHGWEDGVLQQAIDTCTSDSGEVSACSVFDLQSETKQRECTFDMPSTLANEDVQMHADGLPGPMGIQWGPAYASMSMGSSSSSTSAISSVPTTSVDSVSIGVSIEIGNVLNHAEATTTTSTTSTSSPTPTPTTSIHVDQYTEEIVYLQQDVIVMVGEGGIPYATSTGTQRTVSTAITTATQTSTVVSYVEKRDSAPAEPEQRDPSAEKALRQAHNRHRHSHKRHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX7</accession>
    <name>A0A1Q5UIX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000213">
        <property type="protein sequence ID" value="OKP12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIX7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="108"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="31933" checksum="7B7425FAD507FD65" modified="2017-04-12" version="1">MPRGWYLAQGLVPLGYSSSDDDEGPCELPNGRLVCGPHGLVQCSRCCSDYSFMDDVVGEHREELEDDENDDEDHDLAPAGTPSTIGVPSLGPNVLTHGHGLRCTYPNDNSMLLIMTDGACLNNGQANPKAGWAFFQGLNIEGQPLVVSGRLETQGPWGDDGIQSSNRAELRAVIAALRFRHWPGEGFSTVVIATDSEYVVEGSTQWAKTWVQNNWRRKGRMGNDDVNVKNKDLWEMLLGECENAHRQGLAIQFWKIPREWNTLADEGAKKAATAEETPVEWLDYQGLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ93</accession>
    <name>A0A1Q5UJ93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_1888</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ93"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ93"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="94" mass="10332" checksum="8F14A81394BA0D5F" modified="2017-04-12" version="1">MSFLFGGQPKMSSEQKIAAAETEVEMISDMFTRLTESCTKKCIPTDYREGDLNKGESVCLDRCVSKFFDVNIKVSEKMQQGAGQQQGGGMGFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJD9</accession>
    <name>A0A1Q5UJD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,2 mannosyltransferase KTR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJD9"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="45708" checksum="1FB3690D9C93067D" modified="2017-04-12" version="1">MSFSARYTRYLVFAVVGLAFFYIVTRSSFHLPSAASFPRPQPSYDDFKSQKTQYVGTNSSERVNATFVTLARNSDLWEIAKSIRTVEDRFNRNYNYDWVFLNDKEFDEDFKKLTTSLASGNTHYGKIPKEHWSYPDWIDQDKAREAREEMGRKKIIYGDSESYRHMCRYESGFFFRHPLMMNYEYYWRVEPSIELYCDIGHDPFRFMKENDKKYSFVISLYEYIDTIPTLWDSVKKFLKAHPEHVPSGNAMEFISEDGGETYNKCHFWSNFEIGSLEWLRSKAYIDYFSSLDQDGGFFYERWGDAPVHSIAAAAMLKKEQIHFFNEIAYYHVPFTHCPSDEQTRLDLRCHCKPEENFDWKGYSCTNRWFQVNDLQKPDGWDKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJE0</accession>
    <name>A0A1Q5UJE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000188">
        <property type="protein sequence ID" value="OKP12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJE0"/>
    <dbReference type="OrthoDB" id="2580841at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="239" mass="26905" checksum="5444443957BBBDAA" modified="2017-04-12" version="1">MPIPHYGVWVGRPTRYTAERAREDPKSPHIHLKFTDGSSKELEAALNVKSIDKDSRLVFWLTDDFSNSPIIEQLSKLDEGFHLAQWSSVDNNNNSGIEGHRRNRHHQARRLESDLHGLDFIRTDDLINIKSGQVLPHDIPGENNDILDKMEPILKSAIGKSTTYIFGSSFGSGIHDVHMNQGSLPRFDNGIYEDGAILFQYDDGHWEGVFLAFASQRIPTDPNGEPEEDSNTLADILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK11</accession>
    <name>A0A1Q5UK11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK11"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK11"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="488" mass="53887" checksum="F9BA2591BE49826C" modified="2017-04-12" version="1">MAVIELNLRLPSMLHGKKGFDRIIWVFKNVLSQSLAWLFCDLESTSGNQETKPIQKHHPQNIDSEVLKTNLGRISTPSLQGLVSNDSSEGDMQESCGAFAEWIAMVQLGSPRVSADDDVDSYLSRYSVPGVDAASTTDLVSLKWHVQAGNSMEISPSGMDSTLLAVPIEGNDLMDALFPTLPLNPADMDTTLSTFPIEENDLMDASLPTLTIDPADMDLDTMTFTFDDEESANIWASRDQLQDLPTLDTGLQENNVAEAPTTVEPLATLISDEHSFGSTTCPDLSNDSTSEREDSVSSQYTPPTPVSKSPSLERALIMPPAPAGVTSEAQHQIPRDPTAEEIELIAQHLQNESISLNQHPSTPNPPLAHIIMEIRPGGGYPRQVPIYYPMHYHEHTAMPGPQLGQFYQVFPPLGHPIPPTYPMPPTYPMPPRAIQPPPVSNKRTFEFVEPEVPENFVANPNNHGRWQYDRHGNRHYLNASKTKRARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK61</accession>
    <name>A0A1Q5UK61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_1592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK61"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK61"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="160" mass="18091" checksum="663510D449DDC361" modified="2017-04-12" version="1">MGFADFFTDVVSSLGFTEAQAEAPAADVETSTPQDAEPAEKTDESTEETTESESAEETPEESSEEAPEEEEAEAEEEEEEEEEEEEEEPEDIKPKLEEECANSAQCAPYKHHFDECVERVTRQQEDEDYKGPKEDCVEEFFHLTHCATACAAPKLWRELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKQ9</accession>
    <name>A0A1Q5UKQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKQ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKQ9"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12160">
        <property type="entry name" value="2-Hacid_dh_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="33718" checksum="7515380F0E10C90B" modified="2017-04-12" version="1">MKLLYPTSVKLDVQSLQGFSVSLHPYDVKSSIPEEHVDAEILVTWANSSDNLKDAAQRLKNLKWIQSLAAGPNDVLSAGFDASAIVVTTGVGLHDYPVAEHTLGLLLNGARHFYEMRDYQLQSKWPGHLGGSFPRSDFTTLRGSRVLIWGYGSIAKTLTPYLTALGANVRGIARSQGVRNGVEVYAEDKLPELLPETDALVMILPGSDSTINALNAERLKLLPKHAWVVNVGRGVSVDEDALADALEKGEIAGAALDVFKEEPLPESSRLWKTPNLIISPHAAGGRPQGCEGLIADNLRRFLAGQQLKNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX7</accession>
    <name>A0A1Q5UKX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX7"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="2">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="190" mass="21247" checksum="B02078F20FEBDF00" modified="2017-04-12" version="1">MARYRAGTRLWQSITRNPCLRCRYSSKPQTTDIKSILAEPSWSVRSLLPNKTADLSTASVTPQKLRHLLRLSALPQPSTPGEEQSMLRTLESQIHFVQEMQRVDTTGVEPLRSVRDESAAAVKETTIGLDRLKDAFAKERVSGRRRRVQRVSSARNGHPEEAIWKGNALDSASKKKGPYFVVETGSSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULH7</accession>
    <name>A0A1Q5ULH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000135">
        <property type="protein sequence ID" value="OKP13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULH7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="12067" checksum="2AAA712B7B7CB780" modified="2017-04-12" version="1">MFTTTNRKRPSPTSTNAAIARAPFGDEVIKKLEVPTAINDYNHYMGSVDIANQYRASYEIHRKTDRVWFPIFFFFIDAEIVNAYRIQYISKKQQGLAVVIYLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMG8</accession>
    <name>A0A1Q5UMG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMG8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMG8"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="559"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1232" mass="135702" checksum="422F1022364A89C8" modified="2017-04-12" version="1">MAASVLSTPATSSLPVVSSSATTSMVKTAAPKQDIYTINDLLRLRASGETAHDPIVAYPSSGTNYVYYTPHQLDVLVEAAAVQYAKTIPQRLASIDPVQVVGLLGASDFEYLITLLAVSRLGHTVLLLSTRIAEDAYVSLMEATKASFLITHPSFQTMGENVTKRTGATQVPVVAPANAASPEVTSAHLPAAHLHGPTENKHITWVIHSSGSTGHPKPIYQTHSGALKNYANNFGLRGFITLPLFHAHGISCLFRAIHSQKLIYMYNASLPLTAPSLLSTLNDHDEIEVLYAVPYALKLLSESEKGLKRMAGLELVMFGGSSCPKPIGDTLVQNGVRLVSHYGTTETGQLMTSFRDRSDLDWDYVRPGPSLLPYLRWEDQPGMPGIYELCVLEGWPSKVASNRPDNSYATKDLFEKHPTTPNAWRYYARLDDTLVLENGEKANPLVIEGVARKNPNVGEAVAFGSTRPRLGLFVIPSDKCHFQTDEELVDNVFPDIEACNAELPAYAYISHDMIHVLPKDTVYRRTDKGTVIRSAFYKDFAEKINEIYEAPDQQGDLVLEGPELIQFLRESLLDIAPSVETSSLGEITDIFSLGIDSLQSIRLRSAITRTLDLGGQKLSQNFVFENPSLQAMADHITALRSGEALKEQASVEERMQALIDKYSTSFKTHVPVDREDDGDYVVLTGATGSLGAHIVSQLVQLDRVKKVYCLVRAKSLKAAYQRVTESLRARAVYYTISPTVVRKIVALPCNLSKPTDLGLGEDAYANIKKSVTAVIHCAWSVNFNWALESFEDSCIAATRNLLDLCLSAESPRPASFSFCSSVSTVARTPGTWAPEALPASLSYAQGMGYAQSKLVTENIVNRAAHATGMTARVLRAGQIVGDTVHGIWNATEAIPMMFQTAKTIQALPQLDDVLSWTPVDVMASSIIDLSLASNAAEVMNVTNPTLNHWTHDLLPQLKGAGLDFEQLPRQAWLQRLRDSNQDAEVNPPIKLLEFFTSKYDNNNPTRTLLYDTKKAQASSPALARAQGLNAEFISRFVNYFTSQCWGQSSKPVISRNVFVLIGPCGCGKSTAAQALKQHLDIPVIEGDSLHSPLARQKMANNLPLQDSDRWDWLSHIRGAVMGRLLESETPTVAVTCSALRTVYRDELRRLSSLFDFPVTVTFLLLLMQDREQLRDRMVARENHYMKSTMVDSQLDLLEDPIDEPDVLVLDASREREEVLDDVVRTVEDILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMQ1</accession>
    <name>A0A1Q5UMQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMQ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMQ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="16289" checksum="694BCA96232E89F4" modified="2017-04-12" version="1">MASRFLEKQPRTDRLEAADAPQSNKDTASKSRVFARNAVVFSFGVILLELGYGKPWIRLQEWAFKSLPIERQTDYYAAEKLAQAAGLRSRMGLRFSTIVRTCLGSDFGLGENGLASKQLQGIFPVVVIVALKEIEKGLIELGRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP66</accession>
    <name>A0A1Q5UP66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_19</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP66"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="430" mass="47016" checksum="33ADB4E660382C10" modified="2017-04-12" version="1">MFYTDPIPALPPRHFWKHNVPLARTRFDDITASTCRSAQVVVSGSSTEHFERSTNRPPVDKSLLGIQIGSIAGAYLIFVATLLALLLFVGRRIRRTVQSSNYSLQMEMLQPAKSIDPSPISPMSQNIPSPTAGGFTSSWGSIPRGGRPSQTSVNGSMVTIDESVVALDRQRAQDQMEMLYAAVMEHDAQKASGVNISSRDADSQANSPDSQYTNPFTDRHASQSMEPSYREPLKSPKSNGSRLSKLFSSKSNSNPDGGKLRSPRFPVRKLGISSPLASPDLHASRSYAQDQAPLSPRFYNPGPPPTAPRAGPAVAQLVPPPTTRTRAPPTPLNLSTAGQPPSNLPFRDAYPLQSAPATKTTILERPTKNRNGPVTGMPTPYSAYMPFTPVTPFTPGRMVTKRERRREERENGLRVLNEDDLVKDDNDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ73</accession>
    <name>A0A1Q5UQ73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_13100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000075">
        <property type="protein sequence ID" value="OKP14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="36943" checksum="AC068ABA5CE3E642" modified="2017-04-12" version="1" fragment="single">CVSQAFSLATISPELAHFRLGHVGQPTAKINHHRIGDEVQGDHEFNCEPCRLAKSKKIISHTPQKRATKPFEFLHIDLQPCKPTGIGGIDHALIICDDATRRRWAIPIKTKGSSSDVLIDWATQIFNIVGCWPFEIRTDGDLSFLRFIAWIKQKGTAFTISPPATHEQNGVAESSGHIVMQGARTLMISAPNAPAYLWPEAAMATTYVLNRIRRPGEIESPIEKWNNGLQLREAGPIDLGFLRVWFSKAYVHIPKEQRVQGKKMEPRAWIGYLVGYEGNNGHIYRIYDPSKRQVVLRRDVAFWEEPLPIRHLPSSWIAAKYASKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQH3</accession>
    <name>A0A1Q5UQH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQH3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="26244" checksum="8A404D1A1A39C33A" modified="2017-04-12" version="1">MQHLNHHLLLRPGLVEEQSSFIESDYLGTCGSYESMPYDNQGLLSDELQTCVPGLNLLNEVFPCLWNQDMTHDEGAVISKHELYSSTSLPNIEAPELSDRSISISAPPSEEQRNLDTEPKSDINHKQITPRQKIAHSQSERRYRQNLDAKFLQLEDVVNQSHNEKTKPGSRTSKRSQRVQLLEMARLHILELQKEVTSLKRKLHVLREATMPETCRFTIEDELIGVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQS6</accession>
    <name>A0A1Q5UQS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQS6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="59"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="493" mass="55318" checksum="59CE93EEF13A5F1B" modified="2017-04-12" version="1">MQSAPSPRGESPVNPDGLCDDRYGAHPYRYSHHQTLKATPPSERGKIYADEAFRLLRPKLVIPSLETVQACLLLGQFLGGEGEYRTKHIYVGIARLHAEVIRLWEIPDDLPVVDREERRRTWLTVRISYQWSATDMGTGPIAVPCSQLSLPCVDDLSFHTGPAAGLQEGSSAVGPQYGLWCQMAGTLEIFDKVASLLRRLSQSDGISFTTYCSEAPLLAQQLRQWANDLPENLQYSIFNLQSLSELGLGRTFLAMHIGYHHFYQMLYFPFLHISVAPGSEHLALGSNFFRDCALECKNSANTVSEIVQTASTKKDCELLCHLYAHITVVSSCVHLHTLLLSEDAKELEMARERLLLNFRYLTILKAYWPAVDRSAHRLRVFQNLCMDSISNPFALDNWMARFLTEPTSIIAEREDMMFAIPSMGQPEISTLLQSTQDTSGVAITTDTTDPLGEWSLSTVPGFDSDSSMFSSLLNDRDLTTEDLVKNSLEWLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQZ3</accession>
    <name>A0A1Q5UQZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000053">
        <property type="protein sequence ID" value="OKP14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQZ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="18627" checksum="DA32BE7D40AAFCF1" modified="2017-04-12" version="1">MGAVRKSTYSARRPDFRRQLQRALSLSSFETEDTRSASKSSAGDTTEDQLSIHSENDGSSVQSGSVGRNHEAQIDPALFSTARDVEKIEGQRDLPEDRDLIALECVAENVESSMNNQESLNEVVRGDLANILSRLAIMEEKISKADPNERQASENRQTERRRFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR28</accession>
    <name>A0A1Q5UR28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR28"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="70" mass="7812" checksum="749A69415F08E10D" modified="2017-04-12" version="1">MTEHTKSALEINDDKLEEATTTAVENVASETKSAVPQTGAAHELTLRKVLRDHPALVWWSFYWAMAGVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URS5</accession>
    <name>A0A1Q5URS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anucleate primary sterigmata protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5URS5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="2">
        <location>
            <begin position="926"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1302" mass="142645" checksum="E5565213E86528A7" modified="2017-04-12" version="1">MPSVAQPSPAPSSTSRAHSKSRSRSRPARRRRDSSPAPPSSPPALPTPAFSPDGHSDLDDELEEEDTLSPFDARRITPTLHASLVSEILNLRREVESKTKAIDVLEQSLDESRTESETLSENLSRATRESRSLKHQIQLLEGGTSSAMTELARERDEAVENINDVRKKLEQTQKRARSREEEAERTQMLWDRDRETWENERRNLERKVHVVEGRLKTVLSEVAAAQEAGTLVSHHSENDDTEKDKTKGSDTASVASSSQGRRRTSMTSVTTDEGDNDAHYHNVRYSVMSMAPGKGDSGLNLAQELAFDEEEEDEFVASEDETPASPEALPEERPLSVHSAASHDISSKARKILGLSMQSNAAAIAADFRTMDTFSPVKAESASVEYRDTGIQYSPPPSPESLVAVEDVEPVPADLATLDATTEGHDELSEMKDSSTLTIEVEMVSSSCQTLGELPSPPWTPKVPESPVRSAEVTPEPIQMASTATQTESLPEAEPVEAKKASLSPNDLPAQMDIPMIAIHPPASEPPSPRNSVVLPPQTKNVSVQANFRSVVEGRSVAIQTEEIRIDQRPVKLPASLLPSAIPDLPIRSEVKEPVYQPYRPPVPPPRSAKREQRPFNADRPVKPPRAQPSELVQAYPGNNDNGPLSDDLVSSGLRRPFRSSSLFAGFEQLSDDEDPAGEERDIFTDDELLNRPFASYTLRRGKMVNAKSRPSLDEMTLPEIDEHLSDPESRPSDVARGSRPVYRSGASATSSVRQPGMRKMAMISSGAAAHQKTRARSPSEPSLESGSAGSSIAPPFPVPIRLSSRKILNGSDGPPSPTRSARQFSDRGARTTIARKPTLRRVRSAAAMSNTDLTERPETQSSPRSASSFALDSPPSYNPPPMPFDDITAPRDRRNVQKRASHRAQPSESWNRERQDSVGGVQPTSVVDAIAQTMVGEWMFKYVRRRKSFGMGESKDNWEGKNPDEVSANITNSGVRHKRWVWLAPYEGAIMWSSKQPTSGPALLGKSGRKFTIQSVLDVKDDNPMPKGANTPAPFNRSILVLTPQRALKFTALTVERHYVWLTALSFLSHSSMGLQDLAAIPPAPQEEAASPPPLATLRRNPIRDSIRVAKGKPRPMPKGKRSFPSAPVPELPSAGDLDNMAADAPHVPRFSNHSSHHHTRKRSNTAPRPPALHAIRSFSSQGTMPSTHSGTTGSNEPYFSPVVPPALPHGIRSGRSSISRTSEGSGRTTNTATTNIFDVGTVRMEAFIDHHAEQINRPRPPVPSVKMRHARKTSSQWSAYDAPSVDESELSFRSDPFRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URS9</accession>
    <name>A0A1Q5URS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000020">
        <property type="protein sequence ID" value="OKP15181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URS9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="22113" checksum="6EB5DC285AB7F7A3" modified="2017-04-12" version="1">MDASQARPGKDHPEDQLANDHPLTGKPAPENQDKPQIAVDPPSDPPVVSRESTTVLMIELTTVGQPEDPQRPPLMDQPLEPAMEALTRLEREDPKLAFQAARIVGLYRRLWESCTSKHIEGSKLAKANHVLRETHRHLTDERNKMQSRHDDQIARLQFFDQALESSRLRLSDILKDWDRYSEGVLAQSTVKSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNI7</accession>
    <name>A0A1Q5SNI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNI7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNI7"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO89587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="969" mass="108260" checksum="893F453E20F57ECE" modified="2017-04-12" version="1">MASKDGGQAFAPVLAAVATMQGNVPRSEKAQAHEFLEKFQKSVEAWTTTHALLQSSDVPVEAKLFAATTLKGKIIFDLDQLPPDSIVALRDSVLNLLVAFASGPRPIQTQLCVCLASLAIQMLAWKDVLATVGSVLGSSAGDCVLEFLKILPEEVTEGRKINLGEDELIERTKELLEDNAEQVMQLLIQYSQSSPTAATNPRLLDCITSWLREIPAAQVIDSPLMDVILKALDNDVSFDAGVDCMCTLYRDTKDVHESLPIIQALYPRLMALRPKIAETAEAEDLEAFKGITRMFAEAGEAWVVLIARMPGEFRGLVEAILECCARDWEREAVSITFIFWYELKQSITIERYNEARLNYQDIWSQLMDIMVKHLEFPTPEEGETDLFGGDREQEEKFRQFRHAMGDVLKDCCSVIGVTDCLGKIYHLIQQWVGKYASQASNEHVPHWQELEAPLFGLRAMGRIVDPVENTVLGQLIPLIVQIPEQEKIRFQAIMALARYTEWTSMHPETLEAQLNYVISGFQHPSAEVVQAAALAFKFLGTDCQKLLGGHIGQLHSFFESVLDKLKPTSQEEVTEGVAAVVSVQPLEKIYDSMKMFCDPIMQRIMTLANNAQTEEGQRAVADHLGLISIFVQVVTPIVAPGEENPAVKYCGEILPIMTTIVMNFTSSTPILERVCRCWRAMIISYRTAMIPLLPTLAESIANGFQASREGGFLWATDAVVREFSHGAEYVDEATSNAVFHFYEQQATAFLRIMNDLPPENLPDVIEDFFRLSCDAVRYYPKKCISSELAIPIFSAALSALTLQQVDPLIATLHYYRDLFSFAFEKPLVSEFTSPDEEPYVNPPEVREAVKNLIASQGQVLSQRVLAGMIFTFPGDCFPDASAIMMTMFELLPHETGAWLQNTLQMLPAGAMKPAEAERLLKNIAEKVQSGEIRKIRVLLQDFTNSYRRRNVAPRDGLGRLEATRFRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNS0</accession>
    <name>A0A1Q5SNS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leptomycin B resistance protein pmd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_13717</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SNS0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="898"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="922"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="104"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="429"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="776"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1100"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1345" mass="146768" checksum="42BD00FB6FB2232D" modified="2017-04-12" version="1">MQQPEEGATAVEKIPDEVSAGEQVSSTQEKIAEKNYDSGSTLSGIAKDNNGSKTALSLDDDAIFAHLPQHEKDILKKQLDAPLVKISFFGLYRYASTMDILILLVSAICAIAAGAALPLFTILFGSLTTAFQGIQLKTMSYDDFYHELTKNVLYFVYLGIAEFVTVYISTVGFIYTGEHITQKIREQYLEAILRQNIAYFDKLGAGEVTTRITADTNLIQDGVSEKVGLTLTALATFVTAFIVAYVKYAPLAGICTSSIVTLVLIMGGGSQFIVKYSKLSLESYGAGGTVAEEVISSIRNATAFGTQDKLAKQYEVHLRTAERWGTRMQMALGVMVGGMFGVMFLNYGLGFWMGSRYLVEGKVNVGQVLTILMAILIGSFSLGNVAPNAQAFTNAVAAAAKIFSTIDRVSPVDPTSDEGVIPDHAEGEIEFRNVKHIYPSRPEVTVMKDVSLSIPAGKTTALVGPSGSGKSTVIGLVERFYLPVGGSVFLDGHDIQTLNLRWLRQQISLVQQEPVLFGTTIYKNIRHGLIGTRFEDEPEERIRELIENAAKMANAHEFIMSLPEKYETNVGQRGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGVVQAALDRAAEGRTTIVIAHRLSTIKTAHNIVVFVNGSIVEQGTHDDLIETAGPYSKLVEAQRINEEKEADALADEDVEDDSDEALDKQNIARVKSVASGSTALKDEEAGALFPEDIRRADTRKSVSSVILSKKGPDPKAKYSLWTLIKFIASFNKEEWKYLVIGLIFSCLAGGGQPTQAFLYAKAISALSLPPWEYAKLRSDANFWALMFLVVGIVQFFTYSINGVAFAFCSERLIRKARSKAFRVMLRQDISFFDREENSTGALTSFLSTETKHLSGISGQTLGTILMTSTTLIAAIVISLSFGWKLALVCISVVPVLLGCGFYRFYMLAAFQARSKLAYEGSASYACEATSAIRTVASLTREDDVWGIYHDQLDAQARVSLISVTKSSLLYAASQALVFFCVALGFWYGGTLLGHGEYDTFRFFVCFSEILFGAQSAGTVFSFSPDMGKAKNAAYEFRKLFDRRPTIDTWAEEGTTVDHVDGAIEFRDVHFRYPTRPEQPVLRGLNLSVKPGQYIALVGPSGCGKSTTIALLERFYDALSGGVFVDGHNIADLNVNSYRSHLALVSQEPTLYQGTIKDNILLGIDQDDIPEDELVKACKDANIYDFILSLPEGFNTVVGSKGGMLSGGQKQRVAIARALLRNPKILLLDEATSALDSESEKVVQAALDAAARGRTTIAVAHRLSTIQKADIIYVFDQGKIVESGTHAELLKSKGRYYELVNLQSLGKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP69</accession>
    <name>A0A1Q5SP69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000771">
        <property type="protein sequence ID" value="OKO89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP69"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="20371" checksum="2868EBAD2F965C55" modified="2017-04-12" version="1">MGSVANNAAAAAEGVSTTTTAAIQDADDKMNEEAQKLSSQLFQSYSVGLWSYCMKREGSKIQCSHPSTAFTFDFSTIFGPLMTDVRRLMPTVDWGLVSGYHRLARTIVWLYITALVTNALTALAACRKAYSLKGGRLLAVISFKRRPAIPMISTTEREHYMIACSFEAMAQEKNVQSSVNKVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPN6</accession>
    <name>A0A1Q5SPN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000764">
        <property type="protein sequence ID" value="OKO89964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="144" mass="15789" checksum="E077F0FB85A44AD9" modified="2017-04-12" version="1">MDQQLQVRLSSDLPPFNWDEFYESRSSSELTYPSLHESATSDINSLLSARSYPLPNSHNTRNAQYNTPSPSHGDLALKLASSLNPTNTNQTPLPKPTAPGPQKRKQRGSKNTTPSGENRGAPRDDGGRNGSPEEVRGPLINLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQJ9</accession>
    <name>A0A1Q5SQJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome non-ATPase regulatory subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQJ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQJ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="5">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="202" mass="21615" checksum="D83F64BEE3536C51" modified="2017-04-12" version="1">MGIPMDDNIHAPTVASGPTSGATPRDYSKLTMPDLMQEKERIEAELSALSSVLSSHGVNMTTSLTTFDGFPRDDIDIAQVRTTRVRIIHLRNDHKDVMKYLEKGLHAHFAQLQNAQAAAATATRNGTTVPSAIPASMAGISIADASALGTPFARVNSVEPRSPAAEAGLKAGDTIRGFGAVHWLNHERLSKVAETVQQNEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQM5</accession>
    <name>A0A1Q5SQM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13441</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQM5"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO90308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="34259" checksum="21320FA2B7DB2C43" modified="2017-04-12" version="1">MSRHGDYEAVRKDIAAQLQKPGYDDGSAGPVFVRLAWHSAGTYDAESDTGGSNGAGMRYETEGGDPANAGLQHGRAFLEPIKEKHPWITYSDLWTLAGVVAIKELGGPDIPWQGGRTDLVDDSKVPPRGRLPDGALGADHLRFIFNRMGFNDQEIVALSGGHNLGRCHGDRSGFEGPWVTNPTRFSNSFFKLLLQLDWKPRKLATGMTQFVYEDPDAEEDEEPLMMLPTDMALKTDPAFLPWVQRYAEDKELFFDHFAKVFAKLVELGIRRDAKGNVVNTDNQLGGYVSAPKKSNVATGPSKAKGEPRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQU1</accession>
    <name>A0A1Q5SQU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carnitine carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13473</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000060">
        <property type="entry name" value="Mitochondrial carnitine carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO90340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="303" mass="31702" checksum="300718314389DF24" modified="2017-04-12" version="1">MSTSASSPQELKDEIKALDVKPVNQTIAQLRSLAAGAAGGLCAVVVGHPFDLVKVRLQTAEKGVYAGAMDVVRKTVAREGLARGYDVGKSLVEKTSVVPVVNGTPQYSIAQISAAGFFSAIPMTLITAPFERVKVLLQIQGQNPPPPGQKPKYSGGVDVVRQLYKEGGIRSVFRGSAMTLARDGPGSAAYFAAYEYIKRTLTPKDADGNVTGELSLTAVVAAGGAAGIAMWIPVFPVDTIKSRLQSAPGKPTIGGTIRTVYASGGFKAFFPGFGPALARAVPANAATFLGVELAHKFMKKMFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS85</accession>
    <name>A0A1Q5SS85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">PENSUB_13159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS85"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="612"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO90858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="869" mass="94883" checksum="1F9195B69C1DE220" modified="2017-04-12" version="1">MTSTADVIILSSSPSASPHILTRLAKNVQRQSELCPEVATTEPLPSPSELFLPPSRSRFFDVPARKDDASKKKRSTTKKTAPSDDKEKDAPSKTRQKAKKVTKEPTQNGLDDLEPQTLDPKKNDVKKTAGSQKSRAKPKAKKETGNLKLAGKVTKASKSNDTQAKTAKTTKAGQKTAAVQDPPVESTEPSESTKPSKTSNALGKDEVLQLGEATRRRRDWTPPKETPPQLITTMDNGTTSDETHEPSAKSRFGGILTDYNYSGSSSDSREVSANEGGPTKRRRIDLVDPQCNPLHGRNSKEDSVVQGDTPSSISSSGRQAKRKPKTQKRFTTLTARMTAQYTSNDVEEDTQADDITQYITKPKPRGNKSRSNDKDPELIVLSPEAAFKVLDQQDVVFGTCSQLERDDSPETLREMQRAIRASESLAFGERGTGYTSGVEQTARSESTSSSMSRFTGVRNLWSVAGRDTAGSLVQAGSVEKVDLTDAPHVSKPKDAPTRHPRLDVSDDEWLDLEYGKPGDSRDETSSSTKALQQPAEPNPPTPAVLAPPVPDTQPAANKSHHTAEVSQPAPMPQYNGFTDAELSRQVASYGFKSVKGRKKMIDLLQKCWESKHGKADQRVGVSSQPPSAAQADNITTAPATKPPSPNPKTKGKTKPKKTASMATPTEPATRTETVAKTTPKKNQQRSSKVGHPPPSSYIHIEEIQDSEEEVFLSPSQVQKRYTEIFSNTATSVRAPVLQILTKDRPQTPTKRKATAFKTSRSTKSTSSTTATKVDKTPSVERGSQLDISIQITKAVRAQPQLSMSTSRSRPSWHEKILMYDPIVLEDFTSWLNVEGLGLIGEDREVGTAAVREWCEGKGICCCWKKNASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSE3</accession>
    <name>A0A1Q5SSE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSE3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15419" checksum="2B7CCA4933ABB9B8" modified="2017-04-12" version="1">MDVKQRVLGRAGQVLGAAFKAQGQDLVLGSYTGAELSLPHDRSRKAPDFIATYQKSGSGIVTGVGEARLPAIRPHPPHPLGSALDKLEKGYEGSLRRLLGLVPTYLLETHIKYGFVTSYDETIFLRKVERNGVVRAYTRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSF9</accession>
    <name>A0A1Q5SSF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSF9"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010224970" evidence="2">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="35345" checksum="CB43C8E457CB80F3" modified="2017-04-12" version="1">MFVKNSLLLAAALTAGSAVARLHGHERRHAHPKPAEVELEKRVGEVVTATIDGVLETWINEWSGVIAAPTSSSTSTTVVQVPTTTVAPAVPEFTASPSNVESTVVPTPAASSGGAWSESPANGQYSRDGFGGVSKAQKVGVLDWDYIGNVGLPWGSNIIEVAESAASQYKHVLRFEGSHSEPWNVVFWNTYGPDNKMTGFWAPNKALHFTLAPGEVKYVAIDDNSQGGWAAAPGSVPTTNFGQYAATWGEFDMSSEKNDGFSGWDVSCIIAELNDLEIQGMRICNHLGQDCSAIGKGLSSLLNAYTKNDQGNNHLAVAQASGPVRLVVQLDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ST20</accession>
    <name>A0A1Q5ST20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000755">
        <property type="protein sequence ID" value="OKO91066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ST20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ST20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="12710" checksum="6EDF255832B24858" modified="2017-04-12" version="1" fragment="single">MASTEVGRSSEQSPLDRFSSILERKFKVQLDRLEKRITHLVPPWWIPPFVRVNDSAEEAFKEHDAIEPGTLCVYTDGSGIDSHVGAAAVTRAPHANGPWTKRTQYMGTSRTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUC2</accession>
    <name>A0A1Q5SUC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUC2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="115" mass="12873" checksum="82BD2131AAD52BB8" modified="2017-04-12" version="1">MAAKFAVKSLDHLVLTVRSIPETVAFYTTHLGMRHEVFSTPANPAIQRNALIFGSQKINLHQSGKEFEPKAQKVQPGSADLCFLTDENVEKVLQAFQDAKIENFQLCLSVPRLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUP2</accession>
    <name>A0A1Q5SUP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUP2"/>
    <dbReference type="OrthoDB" id="5357372at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28702" checksum="792DC5303B761F92" modified="2017-04-12" version="1">MIRETKKLVSAKDRNVEASLNEADNVRNFQFDSTKLPLKVKQLVIYCDLSRSEETDDKKNYYDNDVNQALVKSECIAACQGWKPPTLAYTIVWTKDHEASQIQLCLWMLEWAKKIKGLIDAKYLNKKARTIEFLANWAVGHNIVLSTTDLESILDKVILHEMTHTVVGGTSRDIDEGSLLKIRYRWKRCRNLAKEGHASRTRQGQQNADSTALAAFVNFALGSICVVYLNLSTAIKLSEEGIQVHEDGSLTKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVU5</accession>
    <name>A0A1Q5SVU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trichodiene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVU5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO92072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="302" mass="34557" checksum="91A497563B1346C9" modified="2017-04-12" version="1">MHRKYGPIVRISPYELHINDPEYYDVLYSREAPRNKSLHLTGMFGAPASAFGTVDHRRHRIRRQPMNPFFSQQRIRQLEPMLRGMVDKLCDGMRAWIDRRAPLHMYHAFNAFTTDVVVEYTMGNSFHYLDDPDFSPQWSTTIQAIVRAGMQFKQFQWFMGLFEILPRWLVLSINPDIGPVIDQKAESIRLANLIIDSQKADGVSDSKAVVPKGTLFHALLDSNLPAEEKSANRLSQEVFTVIAAGGETTAKNLTTVTFHLLNNPDMLQKLREELNRLDPDGTASLKDYEAMPYLVRAHPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXN3</accession>
    <name>A0A1Q5SXN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXN3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="496"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="538"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="622"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="706"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="790"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="832"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="990" mass="110178" checksum="F67E7C0C1E5A1953" modified="2017-04-12" version="1">MKLFPTIARQLVTSIPQLIPAIQEAINDEPDITGKSLKSQFDKLILHPLLSLKLTSRPAPTIVIVIDALDEGERDEEMRIIVQLLPLLRKSKAVCLRVFLTSRPEWPILQEFANITTREHEDLILHEVPEPVVRHDISLFLESRLSEIRKTRSLPNSWPGDMYFRRLVSLSVPLFIFAATACRVFEDPHWDPDKSLKEILAHTNDGSEFKATYFPVINRLLKGQTKRKEGILVHEFQEIVGTIVMLESPLSVISLSQFIGLPKEHIDRRLDMLHSVLDISKDPTQPVRLFHLSFRDYLLDHETREKTPFGLDPKEMHYRLTVKCLSLCESLRKNICALSSDAAYRTELDRRKVDDYLPAALQYACKYWAHHLVQCQNLNNVMHDAFLFLQTHFLHWVEAMSLLGLTSAILGILDTIQKGISGEESTSVLKFLHDATRFVLKNHQIVDKAPLQTYCAGLIFAPRTSIIRTEFKVDLPSWVGQLPHVRERWSAELQSLEGHSGWVQSVAFSPDGRLLASGSVDKTVRLWDPATGALQETLEGHSGSVLSVVFSPDGRLLASGSRDKTVRLWDLATGALQETLESHSDEVESVAFSPDGRLLASGSHDYTVRLWDLTTGTLQKTLEGHSGWVRSVAFSPDGRLLASGSHDYTIRIWDPATGALLETLEGHSGWVQSVAFSPGGRLLASGSHDYTVRLWDLATGALQEIHEGHWGSIESVAFSPDGRLLASGSVDKTVRLWDLATGALQETHEDHSGWVLSVAFSPDGRLLASGSHDNTVRLWDLATGALQEIHEGHSGEVLSVAFSPDGRLLASGSHDYTVRLWDPATGALQKTLVGHSGSVLSVAFSPDGRLLASGSHDYTVRLWDPATGALQKTLEGHWGSVLSVAFSPDGRLLASHNTVRVTEFLFFQDGSLLNTNLGTFDVQSGRERHASNSIRRNLAISIKHRRWITLNGEKVLWLPPDSRPSCSTINGDKVALGHKSGRISFLEFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYL1</accession>
    <name>A0A1Q5SYL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000735">
        <property type="protein sequence ID" value="OKO92955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYL1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="366" mass="42730" checksum="AAD88626BFC23B1A" modified="2017-04-12" version="1">MVPRTRSTPSTEGAPNPPRIAEEIPIATNQGLTPTDLDANLAATQATIEKLQRLKDLQDQAETLRSQLMGRNPDETLSNPYQDPYESSGKGQDIKLKNIPTFTLNSSLQQRQEWLLDLQQQFEGDLRRYHDGRTQILGALSYMDTTCRQRWYRHIDEKSPITHRNLKEDWPYFKDWTLTLIKNGASLQSEVMGQLERARQLKDEDPREFHARLDTLERHFPRVAEKERALSFFAKLLYDLQNDIRRHIIKLPETREEMIDIAYHFWDLQRLETNRKRKHTETTDEPPRKRNSTKRTQDNKRSRKPWTDKNTPAKDRLNPIGEDGKRNRCFNCGSEKHYSNKCPDPPKDKPTAAIQSALQGNDSETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ00</accession>
    <name>A0A1Q5SZ00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ00"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ00"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="12730" checksum="3ABE6E3054EB0D16" modified="2017-04-12" version="1">MEQHAPQKILESLHTFSPILLVFGFCAAQVFTTTTAAIKLKDGTGSRQLPQCTNGTSAAYKKKSFSPITKGVFNGLSVALLATYFAEAAVCVTHVVIARSEQWWCGQSVVVCRYSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZC9</accession>
    <name>A0A1Q5SZC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZC9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZC9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="377" mass="42137" checksum="5118E18882CB4164" modified="2017-04-12" version="1">MSATVTITQPVQPDIQYHPDYVKYQARSRQRKETESLQTSLPAGFPQKLTSPLVWEGKDIEQRSDWIYQLSDEQLDEIDAGLKSFKALNKPLGYNNESTFPLPTLRPILRNLSKQIHHGRGFFVLRGLRIDDYSREDNIIIYTGVSSHIGNIRGRQQDTRLQNGKSPVISHIKDITSTVEAERIGAPSNTADKQVFHTDAGDIISLLCLSPSAEGGESYLSSSWNVYNILAKERPDLIHTLSQDWPIDGPERVLIQYARRYFTGFLAQPRSTNIPPISEAQAEALDALHFLAEKHRASLGFQKGDVQYVNNLSIFHARNGFKDQPGKDLKLLGALDSGIKSRLHVYSGMESVGDVRGKGDHRGPTSPVSVFAYLVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZD9</accession>
    <name>A0A1Q5SZD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_12441</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZD9"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012434431" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="48"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO93378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="364" mass="39946" checksum="ABB727BE5596DFFB" modified="2017-04-12" version="1">MRASLVIAALLAGAAQAAPPSPPHLPGNNNIDLNKLAQRKGKHWFGTAADIPGTAETTDAAYLKVLKKNFGEITPANAMKFMYTEPQQGVFNFTEGDKFLEVAERFDSKVRCHNLVWVSQVSDFVTSKTWTAEELTAIMKNHIFKTVQHFGRRCYSWDVVNEALNGDGTFSSSVWYDTIGEEYFYLAFKYAQEALAQIGAHDVKLYYNDYGIENPGTKSTAVLQLVSNLRKRGIRIDGVGLESHFIVGETPSLADQLATKQAYIKADLDVAITELDVRFAAAPYYTAAAQKQQAEDYYISVASCMNAGPRCIGTVVWDFDDAYSWVPSAFAGQGGACLFNDTLQAKPAYFAVADALEGKPCSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZV3</accession>
    <name>A0A1Q5SZV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZV3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZV3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="36057" checksum="215E84BE26004E8C" modified="2017-04-12" version="1">MTTATAATSAAIPLTTVFTPPASCTSVNLVSSDCSKSTCDGLYNIVQTTDTNCYPSGWATTATWFSPGLYCPTGYTVNDTNVVTSGLGITETQARCCPSYDAPAESCLPYAKSPIIANLSDSNRGYAFATQLQAPWWTPEPCTKISTTTTVLEFTILGATPTTTTAITYKNPIIHAYPIELRWQSTDSVDGGVKSSATVELTSSSGTSATSTSTSTGGASTSTGLSTGAKAGIGVGVAAAAIIAIILSLLFWVRRRRNQKAVSTLPSAGHTRGGSIFKKTPQQEPVELPTYTPELHGSFSPHSELDSSDRGFSERGYSEHGHSEGARSEFGQIESQMQRSPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T029</accession>
    <name>A0A1Q5T029_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(S)-ureidoglycine aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T029"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T029"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071522">
        <property type="term" value="F:ureidoglycine aminohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02212">
        <property type="entry name" value="cupin_UGlyAH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02211">
        <property type="entry name" value="cupin_UGlyAH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017627">
        <property type="entry name" value="UGHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044697">
        <property type="entry name" value="UGlyAH_cupin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044704">
        <property type="entry name" value="UGlyAH_cupin_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040771">
        <property type="entry name" value="AAH_UGLYAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008373">
        <property type="entry name" value="PRK11171.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008376">
        <property type="entry name" value="PRK11171.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03214">
        <property type="entry name" value="ura-cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34571">
        <property type="entry name" value="(S)-UREIDOGLYCINE AMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34571:SF1">
        <property type="entry name" value="(S)-UREIDOGLYCINE AMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="68"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="31434" checksum="B5045E8BD7041898" modified="2017-04-12" version="1">MGNDKKIGAYYAPTGGLPPQTQLLTDRAMFTEAYAVIPKGTFSDIVTSFLPFWDQTRLWVIARPLSGFAETFSQYIMEVQPGGGSDRAELDDGAEGVIFVVEGEVTITLAGESHTLTEGGYAYLPPKSGWTLRNAGAATARFHWVRKAYEYVEGLDAPNPLFLNEKDIKPTEMPGTNGAWATTRFVDPSDLRHDMHCTIVTFEPGGVIPFAETHVMEHGLYVLEGKAVYRLNQDWVEVEAGDFMWLRAFCPQACYAGGPGKFRYLLYKDVNRHMKLAHHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0C1</accession>
    <name>A0A1Q5T0C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0C1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="70" mass="7998" checksum="CCD08741875B8E01" modified="2017-04-12" version="1">MDKAIAAVLNLDYRLIPLSFRPVPFWDEGLNGRFTKATKENMVSSFWAISCDVSQGTEHRTRLKVSVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0C7</accession>
    <name>A0A1Q5T0C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_12007</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0C7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0C7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="16">
        <location>
            <begin position="295"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO93728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="598" mass="67183" checksum="83F6E6791587D972" modified="2017-04-12" version="1">MPTISVDKAALFKELGREYTTEEFDELCFEFANNQQTTDQDRPIVDGVQEPPQLKIEIPANRYDLLCFEGIALMLNVFLKRKALPEYKLVPPANGQLEEIIVKEDTTKIRPYVSGAILRGVKFDKARYESFIALQDKLHQNLARQRTLVSIGTHDLDTVKGPFTYEALPPKDIKFTPLNQTQEMNGEELMTFYEKHQQLGKYLHIIRDSPVYPVIYDSQHTVCSLPPIINGDHSKISLNTTNVFIEITALDRTKVEIVNRMMVTMFSQYTSEPFTIEPVKIVSEHNGQTRVTPDLAPRTTTAEVSYINQCCGLNLTSAEISNLLTKMAYRAKPSTNNLDTIDVEIPPTRADVLHQCDIMEDVAISYGFNNLPRSFPSKSGTVAQPLPINKLSDIVRVEAAMAGWSEVLPLILCSHDENFAWLNRKDDGNTAVKLANPKTTEFQVVRTSLLPGLLKTIRENKAHSVPMKIFEVSDVAFKDMALERKSRNERHFAAAFYGKSSGFEVVHGLLDRVMAMLKSAFIIAEEGLNNAAIGDSQYYIQALDDPTYFPGHSASIHLRVGGKDHVIGSFGILHPTVLGKYELKYPVSTLEINIEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T189</accession>
    <name>A0A1Q5T189_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose 1-dehydrogenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T189"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T189"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="25186" checksum="45252F1F9446ED71" modified="2017-04-12" version="1">MVQSLRLQDKVAIVTGASSGLGRAIAIRYAQEGAKVVCADLTPTARSQEEAGITTHDLITQKSGQAIFVQTDVGDATQMENLVAEAVKVYGRLDILVNNAGISIEARFPAVLHLTDEATWDTTMRVNAKSVFLGSKYGLGQILAQEPHDSGDRGWIINISSIMGMIAGPENHTQTAIFKETTTNLTPWDDLNHRHPLKGPGFPDDIAKMAVVLASEDASWVTGVCLPVDGGYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4B5</accession>
    <name>A0A1Q5T4B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4B5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4B5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="25248" checksum="14701F9585F23A0F" modified="2017-04-12" version="1">MESERSLTGKDVVSKLFQNEPAPKDYLGELYDLHRQAFQTSSHKELQIPPSDSSSSKSNTVIEDADMLLNVFRNRLEWEKFRAESRAKIATYLKSLSQMMDSISTSNSGGHPDIFAMFKSVLDLLVPKYAPHETGTRCSSPSQDTGSVLSATEQDNMDAELPCTGSSSCPILNGSIKGTDFWRASEAARCFDGSTDSCDLGDGLFNGSQDWLNVFSQWVVDLNDADDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N3</accession>
    <name>A0A1Q5T5N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N3"/>
    <dbReference type="OrthoDB" id="3933054at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35174:SF4">
        <property type="entry name" value="BLL7163 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35174">
        <property type="entry name" value="BLL7171 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="2">
        <location>
            <begin position="5"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="15890" checksum="0051CFD336B5DB04" modified="2017-04-12" version="1">MPKFMLLVRATHDSESGIPPSTAIIEEMMAYNTSLSEAGILLGAEGFLSSSKGARVSFTPQNESSVAPGPFTIESIISGFWIIKSKSLDEAISWARKAPFRAEGSAIEVRQIAGPEDFFGNQLTDELKTHEEELRRRTEERAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5T2</accession>
    <name>A0A1Q5T5T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5T2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="20391" checksum="A9725694FED816ED" modified="2017-04-12" version="1">MASFLQPELSQDFDTIVQEVQNQKDQSLTERLNDKNRIQGLERDLAACRAEISQLKTHLTMSYEAVSERFRRIYRSLSQWVSGFPKFPRVALNWQAVGHFVQDGSYSQDLYPLVGYDKENFECERELLLLYSIWLILYKCVFQTVLVGADIDTQVILRHLFESFSSLEPNAGSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T675</accession>
    <name>A0A1Q5T675_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T675"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T675"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="31480" checksum="67CEAE1735BEB7AF" modified="2017-04-12" version="1">MGAGASTPSASAELPAATCPVDHKTREVWLQQNGGKAPHPPSSAPAQEQEQTSTKLQRPLSTDREVSSIPRAGSPAAAATCPEGNKGAPTPYESSPYAASHGCPSNAEAETGHDEASGNWIYPSEKQFFEALMRKGNTPESTSSASELATSVASIIPIHNAVNERAWQQILDWEKKAPSTDPGSKKCGGPKLYSFRGLGVDPQFLSPRARINGWLGYQRPFDRHDWVVERCGGERVEYVIDFYQGKTNVGNGNPSGLTGNAAPGKLSFYLDVRPKLNTYEGWKMRFNSFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6N0</accession>
    <name>A0A1Q5T6N0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6N0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6N0"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178:SF9">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24178">
        <property type="entry name" value="MOLTING PROTEIN MLT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="614" mass="67717" checksum="1C4D41EF1DE48EE6" modified="2017-04-12" version="1">MAYPEFHRHHPELKGGQPVFHDTDGSPVYESPYQGLLCSIINRNDTSALRLYNDCPHSSIFLQAYDAAYYNPFSTTLGCHSYDVLSTLIQIYLSDTSLTEPLEKYLKRFYVSLVHEACSAADQDLVLLLINHNPPLGTLRDRSFRDRTPLLCAAEALGEVGGLMVDAKAGESLPVARQKAREHRDRIEDFIYWLLRSGCSVSESDAFEQDYKHDKDPEKALTLTGTVLGAAIPYATQAMVLHLIAIGADVHARQVWYGVHTGMTSGGGVTPLHIAASYWNLEAMQALINLRSNAEISEMVSVADDEGRLPLHWALHGTADRREEKDNSEIVSRMAETVETLLNIRPDTINARDRQGATTFHYAVDTSLGFVAVSQAIEPLLSAKPSPEILNTRNGRGSTALGEAARPFTLFGGNLNQLADLVKTLITNGADARLCADKGRSFLHVLSNYSWAQDIPPALLDFLLETVDVNQADADGCTALHYLVKNLDQSDAILHLLSRGADVSAVDRKGNTPLHEVMKGKMLRKVYANREVEPLAPNLLRRTRDELILALLNAGASMDQTNIAGQTPKQVLDCVLEEREGQKQREAAKRAKWGEDPIVRQDRGRVVAYVNSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6R4</accession>
    <name>A0A1Q5T6R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6R4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="16637" checksum="BE502587F9C8BA95" modified="2017-04-12" version="1">MDTEVDIAPENLFRPAKRRKFARRRQDDPEETTSAAAESVAESTDKAPGATESKLSDDADDSTHATGVVRLRRPKAIRKGGIGFSATPRPSGKDDNRQTALSTIEDQDKEPIQAMGDRFQMYTGQAEDVDRHMYELYPLSQQSYWSNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9K9</accession>
    <name>A0A1Q5T9K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent mannitol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9K9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9K9"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29838" checksum="D51728D4C5671F2C" modified="2017-04-12" version="1">MSMTVEDSAPGREGFPRPFPNTPTNVLEQFRLDGKVVVVNGAADGIGLAVAQAMAEAGANVALWYNSNDAAIEKSQELASLHNVKSAAYKVDVSESTQVSSTMERVVEDFGKIDVFVANAGMAISKPILEQTLDEYQKQMSVNVDGIVYCAKYAGHVFQRQGFGNLIVTSSMSAHIVNVPVDQPVYNATKAFVTHFGKSLAREWRDFARVNIVSPGFFDTKMGAGPDCLNEAYRMSSLGRQGHVKEIKGLYLYLASDASSYMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAY5</accession>
    <name>A0A1Q5TAY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAY5"/>
    <dbReference type="OrthoDB" id="2431475at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="52467" checksum="0D3409189F15730B" modified="2017-04-12" version="1">MDDNMDDEYVAELLTREARESSQRYQTTGSYMSRRPAGNAPKPNTRFLRHLIKETDSHNTALKRKEERDAKDRLRHLRARPKDDLSSDHSRPTRRDDHRSSSPGLARSRREEGRDRQQRDERESPHPQRRHRPRDSATERDRSRRHRHRDDSRDRSSRDHRDRDQRDHRDKPSRSDRHEPTRKRHSRRETSRSRSRSRSPRRARSSERHRSRKHRRSESPSDKRSSHSRRSRTEHRSGHSPSEKPPIPRDSHSDSTRTAPNPREQRQESASAAAAAYTTLRRDDLDHDSDPLEDLVGPLPPQSHDEGAGPIRSRGRGAYKPRASNIDAHFAPKYDPTEDLPSDDDQASSLNKPSRRPVAGLMTADDDWDMALEALRDRQRWKAKGEERLRAAGMNEETIDRWKHNAAFTGADSTEGNPENVRWAKKGEGREWDRGKVIDEDGHVDVRAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBN4</accession>
    <name>A0A1Q5TBN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBN4"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="554" mass="60949" checksum="3F9D835170A4F635" modified="2017-04-12" version="1">MSRTTTRSITSAGSESAPSPRERSTSARGERSASNPASFSLDTNQYDTALPPMHFHQPPTIAHRRTGSTLKTVMRKIFNRKRQSQADGVEENPNESYYSSPARSSGPIAGKSFLSVPTSTESKRSSPLSEENLQLAETHLSPTSATGGSLPSPGMAPRRRRATLPSVIFSDDESRYAVASAVSDPQEDRPVIPDQERQRIMLQSRRRSRSIGALQDLVVKRPMSPPEWPTRTASLHDSVADSKSPRPGGGSSASDHSGRPSTGTTVTSVTRASAAPSMQESDPHADQISLPPNVGNLMRTMQQDDSLTLEQRLNTIEVKMIDLEFAIARMQSNSVADNPQDRDRSSFRRKEDSFPQTRSKPSYLSSLDREESSPTPLSTSLPTARPTSTSTIRADTLNARTLRPAPSASSLTEYNAISIEQYSALVTLLRREQTARRNLESQVSSLKDDIRHIQRAALHSMENGGTMYPIHSVDSQEFLRFRRALDESDSSSPVRALDEKGNAAFETESDYDPFGPPKWERERDRDRERELELGNGNGLGHGHGGRRVVTAPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBR6</accession>
    <name>A0A1Q5TBR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBR6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBR6"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="75"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="38193" checksum="E4009A2BEA8CD341" modified="2017-04-12" version="1">MASSRWWLYIQAVFWRFLMRIGMFLHTLAPPRPPRPLFTRTVSKDVHLHSVVIHFYCPPDYYEQRRLGHRYPVAVNFHGGGFTLGHATDDGRWAAAVVEQVGAVVASVSYRRAPEHPFPAAVDDGVEALLYLAAHAAELGLDVSRVALSGFSAGGNLAVTVPLRLRGRISTEVKEYFGRADSTQQLVNQTSDLNIVALFCWYPILDFLESRAHRRAESINPDKTLPKFFTSLFDEAYLPDLNDRSSAFASPVRASDRILNEALPRDIFLFICEWDMLMKEGQTFVRRLEGLGKRVRAMMIEKAKHAWDKSANPFRDQGSVDVLYRDACADMKAIFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCE7</accession>
    <name>A0A1Q5TCE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saposin B-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCE7"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013089795" description="Saposin B-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="109" mass="12120" checksum="57483663B8DF662A" modified="2017-04-12" version="1">MKLTLLTMLSALSVTWAIPFTSGADNVLARRDAECDFCKDVNGRMIQEIGNFRTEEKIVSTLENICSLYKRSEQSKCDNFIEKNANELIHILVEESDPSAACTLLGSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCW2</accession>
    <name>A0A1Q5TCW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCW2"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="196"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="509"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="819" mass="93082" checksum="17A8FF45A020284C" modified="2017-04-12" version="1">MTFPIHPVANSQAVLPGSKYRFTVLTDRLIRYEWASDGCFEDRASTFAINRHFPTPQFLVIDNDDGLEIITDHFHLCYDKQRFSPAGLNAHLSFQHTNWGAPWRYGLDEKLNLGGSLNLGGTARTLDLCNGRCDMGEGVISKAGYAALDDSTSMLFDGDFVVGRKPGDRIDGYLFCYGHDYKAAIKAFYSVSGKQPVLPRYALGNWWSRYYPYHQDGYIQLMDDFRARDIPLSVAVVDMDWHLVKDPSVPHAGWTGYTWDRKLFPNPEQFRRDLHERHLKITLNDHPHNGIHSHEDAYEEMAEALDHDTSEKRPIMFDPSNRKFMKAYLEILHRNLEKTACDFWWIDWQQGPYSKVPGLDPLWLLNHFHYLDHGRDGNTTPLIFSRYAGPGSQRYPIGFSGDTVVTWDSLAFQPEFTATASNIGYGWWSHDIGGHIFGVRDDELVARWVQLGVFSPIFRLHSSDSKWNSKEPWMYRSEYCEVMSNFMKLRHRLVPFLYTCNVVGSVEYEPLVQPMYWMYPESDQAYAFPNQYIFGSKLLIAPIVEPRDKTTNLGAVKAWLPPGSRFTDIFTGQSYDADREITFYRTLEEYPVLAREGTIIPMDASPAPGNGCLNVDAFEFVVVIGNDAEATILEDAGDEAPNSTSGKGQRKYVVQFNQAEGKLTAHSVDRPSKFRFLSLTSVPDDLKIYCDGIEQTDEIKVAIEEDCQAPGLVIDCSFSQVGHCITIELGPDPQLSVMNPMHRLETLIMDYQCEFEVKDQLWKVVTDHMKPVNAVIGTLLSLGYDLSIVGPVSEQLLADSRLCLPFVRRTLAEGSATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCX5</accession>
    <name>A0A1Q5TCX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="6033" checksum="D6929D29CFA40281" modified="2017-04-12" version="1">MANNLRPGRRPRPRSILAGSHKVTMANRSARSPRGWTQLYQPQGQPRYSTIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDH5</accession>
    <name>A0A1Q5TDH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9366</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDH5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDH5"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="600" mass="66366" checksum="320FC4DB237B7E1C" modified="2017-04-12" version="1">MAPAGKNYIPSGRPASPGPLAADFFQQQIAKQRNNNYHSTSLRNMVATSVNRTALHPGGVQPGKSHTELEEELHETAHIDYDRVAIIANPSVPALYEDALVYETGTAITSSGALSAYSGAKTGRSPSDKRIVKEESSQDQVWWGPVNKPMTPDVWRINRERAVDYLNTRNRIYVIDGYAGWDERYRISVRVVCARAYHALFMRNMLIRPTREELEHFHPDYVIYNAGSFPANRFTEGMTSATSVAINFAEKEMIILGTEYAGEMKKGVFTVLFYEMPVKHNVLTLHSSANEGENGDVTVFFGLSGTGKTTLSADPKRKLIGDDEHCWTDTGVFNIEGGCYAKCIGLSGEKEPDIFNAIRFGSVLENVVFDPITRVVDYDDSSLTENTRCAYPIEYIENAKIPCKSENHPTNIILLTCDARGVLPPISKLTPEQTMFHFISGYTSKMAGTEDGVTEPQATFSSCFAQPFLALHPMRYASMLAEKIKEHKANAWLLNTGWVGAGATTGGKRCPLKYTRAILDAIHSGELAKAEYETYDVFNLPVPKACPGVPDELLNPKNSWTATTSFSDEVNKLGKLFNENFKKYSDEATAEVLAAAPQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDM7</accession>
    <name>A0A1Q5TDM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDM7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDM7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="427" mass="46432" checksum="52BA73640B27C7D0" modified="2017-04-12" version="1">MHDGLTRPVASNLPTQSHSRSQGPNVILYLRPGPLFQGHAYPVPEGDEPHDLSLDNLKWAANGTNHGGLSPQQSLASMTSATVVTVNYRLGAVSPPPRSNEETIQNSTHTSPNASPSSLSQPQSQPLFYKYPTPIHDTLAAFDWIKTNLNPAHLGVIGSHIGGSLALMLALTEAQSVKAVASIMPVTDWVGLDDYCTTEQANANTSEKPTSKRASKKKNIRATAPRDIVPLLAAREALFSSPERCFDAFASPILFLRSAGRDVPSAFPVYLARPEYPVPVLKNTRPADLDGSFSNQENDLEDDELSETGHTTVRRRKALSRWPPYGLDYGAGGRGWGGNGVRRLEVTLPWVRVYVEGNEGESSETVLADQGEEMVSVMRRACFFGREKGFGERRVSLVRGVGEVGLGVGEEVGGWFERIFDGRISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDT4</accession>
    <name>A0A1Q5TDT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDT4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDT4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="10244" checksum="B46727BB8CDB5758" modified="2017-04-12" version="1">MQGILLSGAPQDLQDKSVWEVPARQLEKLFELSGCLGLDGYITPVQAWNRIVGRLDLSQVLDPRVEELRSAMIPHVKCYGLIDIGILTLGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEI6</accession>
    <name>A0A1Q5TEI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Feruloyl esterase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEI6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012818518" evidence="3">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="281" mass="30395" checksum="BE9D0E1D77C36F26" modified="2017-04-12" version="1">MKIISATHALVLSLAARQSLSAVTRGISDTVYSRLIEMATISQAAYANLCKIPTTITTVQKIYNAQTDINGWVLRDDSRKEIITVFRGTGSDVNLQLDTNYTLASFQTNPKCAGCSVHGGYYLGWVSVKDQVESLVQTQASKYPDYALTVTGHSLGASIAAITAAQLSATYNGVKLYTFGEPRTGNQAFASYINKQFQSTDPNTTQYFRVTHANDGIPNLPPTAQGYAHSGVEFWSVDPYSAYNTYICTGTQDQCCEAQGGQGVNAAHFTYFGMSSGACTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFG9</accession>
    <name>A0A1Q5TFG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_8891</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TFG9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1921"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2184"/>
            <end position="2307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="474"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2317"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="485"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO98974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2358" mass="262100" checksum="48E5F6F1C261E94E" modified="2017-04-12" version="1">MEESHLIGDDLPLPPARLFERLGHLPGYTWDQSVEPFHSTYNHWHIYGFRHAIESDILTPVATSSNPISSGPSSLARYSPRTELRPSSRTPRRASISETSSELSLSRGDQEQIWLPVVARVSTNVISLEREFHMIRSIVQSSDPDCNHTIRPIDLIRLPPDPGDAGTLLVAIFESPGHDRLRDLVTFGPASFVAGAKGDNNTTPSEQIPLPAFLDFAIGACDCLEILHYGVKTVHGEIRGDAFHFSAENGSVKLANVGNGARSFDNVLSEGWSSVSRELGAKYKLQFIAPEQTGRMPTEPDSRTDIYALGLLFWSMLVGKLPFAGADPVEVVQNVLGKRLIPVSAKRLDVPDGLSAVVQKMTQKVVHERYHTISSVKRDLMQIAQLLGDGESEALNNFQVAQGDVSSFFTLPSQMFGRQKEYDMILNVIQKVNKRQASAFAKAFTQSPGTAHALASNSSISEGRVDSFELASVSSDSGSFHLPPRTNSNATSHQLSQVSTPDSGANSDVTFQTSKQVQTPTSQDMPSQTSALPLSSKMKSPSHSRSSYNTDRESHPSIGTNTSQPSTHTFSQSESMGSLSKTKAGAKYRRSGRCEVITISGAAGIGKTDLLNRVQPIIRKSGYIAITRLDRAKRVPFEPFAKILASLLRQIFSERDVTTDYHDSVRSALRPMWPTLHKVLDLPEQLMSPGSKYSQNSPKPSIAQNIAKADRAKNERTKRFQIPGMDHGQTSAEFFLSNAASNNMRLMDIFIEILRTLCQFQLMVVCLDDLEYADDETLELILNIIRAKLPCVLILTSRKDEIAPDNVRALFEAENSNITQLELQPLSEAEIMEFVAAAMHQAPNPTLTPLSAVVQEKSQGNPFYVRVMLETCYRKNCVWYSWKDSKWLFDLDRIFTEFVAPAYGEGLGPGFLTKRLQEIPPAARSILVWGALLGSPFSFSLVQKLLTSEFLFSSDEDDDEGFDLTCPQNATLLRQSEGDIVVGLQYLVQSNLLNPGKTDDEFKFGNDRLAQAALSLSESRNVEKMHFIISQALMKYYHDHRSRYSMAHHVALSSRILKSRVPRRIDYRRILWEAGQIAAQSGARPSALWYFRHCIALLQDDPWNDRQVDVYYDETMRLYIATAEMSWSQGQNEEALDLIEAVFAHGKDAMSKSRAWIIKAKIYAQVGDHHRSMESLLTCLDELGVHLRTPTSFEECDAAYLKLKNHLESADMEAIAQKPISKDPILVTIGAVMAEAMAVTYWDDSLTFYRMAIETMNIHIFRGGFTHISIGCSHLAMIALSRFKDVEFGFRLSDFALSLLERCPELWTQNRGSIVYNLYVSHMRVPMASALPALEASLEASFTIGDPYITLISISSMAMTRLYLGQDMAQLEAFCLDSPEEIPNWTQDTRGGASILAVRQVARALQGKTEYRSADNVLSDDEHRTSEYMAYLDAHASNVDRPRDIYFGLAMIPLFLFGHHTKAIQVGTRLLETTHRLWSARVSYVVYFYLSLSLLTLHNDNPAQGYLDGKMDTVLRYKAEIDFARSCSDANYGMWALLVEALISELRNDHSAAIQSYEAAIDHCQVHGWLLEEALALELQGEFLVRRGAKRAARAVMQEAISAWSSISASGKAAMIAEKHEWLLKTATSARTMDIGCQTVDSLLEITRDAVQEEIVIPSQIEEEDRRHRWIEQNGVTTGERSLDISSVGLDIIDLSSILESSQVMSSELQIDKLFTKMLEIILDSCNGSDFAVIATDFDEQGFAIAAAADADKGQKYFPEGLPLSELEGRMAQEITYYVMRTKEEVLVHNVLEDERFSNVNESYQANFPLGRSVIALPIVQADQLLGVIHLEGKPNWFTQRNVVVLHLLCNQIGISLSNALLFREIRKVSAKNASMIESQKRALAQAREAEQKAKVAEAEAKHNVKLKDDAARAKSIFLANISHDLRTPMNGVIGLSELLKGTTLDKEQDEYVESIRVCADTLLTLINDILDFSKLEAGKMKISTVPLNLKETISEVIRALRYTHRERGLQTIEDLERVPPELVVLGDPVRLHQIFMNLLSNSYKFTPKGSITVKAKVAREGKGRVRLECSVSDTGIGIPDEQKARLFRPFSQADPSTERSYGGSGLGLSICKAIIEDVLGGAIWLDSTLGVGTTVTFHLVFNKAPKKTAVKTPWAQDLSHAEAKEPPRAKARDLSHIPRDQIRVCIAEDNPINQKIAVKFVTSLGLQCEAYSDGKQAVDALRAKSKEGNPFHVVLMDVMMPTLDGYNATRELRRDPDPNVNEVLVIAMTASAIEGDREKCLDAGMNNYLPKPVRSPILSELLDKYLAPVPHPRTRLAIREKSSRGSISFDAGTPTGFSSSGSDEAQKHPLPPTSEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFX2</accession>
    <name>A0A1Q5TFX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFX2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="440" mass="50416" checksum="47FFB8963AD676FD" modified="2017-04-12" version="1">MRYQVGRACAAAWYTYLYKELDLLPNVSIAEEARNAAEDADIYKIIMSAPQRWAVMDDFTRSVNLENPPAPAFLNGNMKFRRALGRRVLPPKNLPDTTADDINIEEDGFIGLKEQLSKAYQLETNPGRIILPGKLLNEGNERECREIRTGINARKIMNNDISDLEDDSDCLPWLIWWPVELNENILRELASKCPSMRHQIAITAILCDYKSLFWSLKPLPHESFFEAAKQSRNTFYLVRERSIRSRETSEFGPYNTTWETSLQPDLEPRDSSAHSSIQFSDMAVPWGQHPRDEWGSPGMYGGQPADPGVVERYMWLSTETAQKIQDESSGIYDDSAGTGYLYIENDDSENELWLKLSRPLKLFAKRTQGGSIIKFDGDLSPLRKEARERNNLVRIREQPLQKKKKKKKKKKKKKKKKKKGNKEGKAYIGRSNQPGPGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH86</accession>
    <name>A0A1Q5TH86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore protein mis14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH86"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH86"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="31125" checksum="25B54E37F08DEBFB" modified="2017-04-12" version="1">MAAPHYRKVELQSPADFTYLYANTVALSRQKLDLNLPPSATNDDQPDPMRERVRELVDEYITRTFTTASSSISINGLDSSSPAFPFPAAFTAPETVEYEPFDSELASRVSTLYAQLESLTTTVAQLRREAPRKAAKVYAAQLAGLIEEESKEDEDETVMENEDEETQDRTAEDVNTDADADAMDVDTQSASASTSTKRRRSARTRPNPAWTLDIPLGTDEEAERWRNGDMAEVYENALRTLQRLQGEGDSEVGKEAGSEGNALATTVGKAERAGRAAEVVESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TME4</accession>
    <name>A0A1Q5TME4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TME4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TME4"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000081">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000149">
        <property type="entry name" value="AAA family ATPase/60S ribosome export protein Rix7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="202"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="511"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="738" mass="81064" checksum="63BCE43BDCCA045A" modified="2017-04-12" version="1">MAPRYRGGRPTLSQGLDREVYQVVRKIIDDQPDGVDRVRLTVPVIHARIRGSNSSLNRKPKKLLEDSLERVLEVVKSDLFGEEEEDSVEGDFEGLEEPPAAEPNGVNQSIVGAWTTTTASKSTPAPKSESTSTSKTTSKRRTHGGESVSKRRKADAAVDRSPPTHVSLADLGGLDDVVQELGDMVILPMTRPQVYLSSNVQPPRGVLLHGPPGCGKTMIANAFAAELGVPFIAISAPSIVSGMSGESEKALREHFEEAKRLAPCLIFIDEIDAITPKRESAQREMEKRIVAQLLTCMDEIALEKTDGKPVIVLAATNRPDSLDAALRRGGRFDKEINMTVPSEPVREQILRALTRKLRLADDLDFKTLAKRTPGFVGADLNDLVSTAGAAAIKRYLDILKSNSGEEMEMEVENEEGDDIISPKVRELRRLITHARENPIGEETETVLVSNADFFTALPKIQPSSKREGFATIPDTTWSDIGALGGIREELTTAIVEPIKNPEIYAQVGITAPTGVLLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKFVGESERAVRQVFVRARSSIPCVIFFDELDALVPRRDDTLSEASARVVNTLLTELDGLGSSRQGIYVIAATNRPDIIDPAMLRPGRLETLLFVNLPSPLERVDILRTLLRKLPIEFNEDMRRLAEECEGYSGADLGSLLRRAGYSAIKRRDTIRLEDFVTAKAFIRPSVTDMKKYERLRRDWGTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TML5</accession>
    <name>A0A1Q5TML5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TML5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8411" checksum="1FBCC1AA93A1BC49" modified="2017-04-12" version="1">MMIIDDLNVGFEWSSKQGICAPENWGRDLGGSSRKSAAHAETVANLSQLVQLGLSSRNVYGVVYPGPVFRGSGLGSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMM8</accession>
    <name>A0A1Q5TMM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="10118" checksum="8EC411C231FBBFF6" modified="2017-04-12" version="1">MGREQWFVFVSGASAQEKMIALARRLAVTIIPTQVERLCTGELGNSGVSADLTQFWLSPLPVPIAGARAGPGDELFEIIAGRVTVGSISSSCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUA0</accession>
    <name>A0A1Q5TUA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar transporter chaperone 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUA0"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP03779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="799" mass="91113" checksum="B553EFEAF88CF96B" modified="2017-04-12" version="1">MRFGKTLRNAVYPPWKGKYIDYAKLKSLLREHDVTGADADASDSDESQWTEQDEEAFVQELLNVQLDKVNTFQSETSQQLRERTTACEAKLRPLAPTTSQEPSDMDDPEKRTIASEVLQELDNITKEVSELEKYSRINFTGFLKAAKKHDRKRGARYRVKPLLQVRLSQTPFNSEDYSPLVHRLSVMYSFVRETLSQDIVQPKEPERGFGRDVYSSYKFWVHVDNVLEVKTFILRRLPVLIYNPGSSKHLDGLTDDPTITSLYFDNRQFDLYNQKVARASEAGSLRLRWTGQLKDKPPIFLEKKIVAEDDSSREIRVQLKEKHIKEFLDDEYHLDKQVHRMEDMNDGEGSVEAQTLKSNVEELQAFIKEHNLQPMLRANYTRTAFQIPGDNRIRISLDTNLALIREDSLDSERPCREPSEWHRTDLDDARMSYPFDAIRTGEIVRFPHALLEIKLRGKAHDAEWVNDLMSSHLVKDAPRFSKFVHGTAQLFEDHVNSFPFWLSALDNDIRRDPETAFHEEQERLAKRAEDDMAVGSFMGGTGSPSGPLSASPFSRWGEPGSRSAMRRASGISEGQNQTQRRISVVAPHPRREPEPVAEPVEESQEPEEPPSRFAAVFKSLGINPNNWTGREVVSLPPGVRHPGIWIKDSGPVRVESKVWLANQRTFIKWLHISILLSSLSLGLYNSAGKHNRIAQALAIVYTFFALFSAAWGWYMYEKRARLIRQRSGKDLDNMLGPIVVCIGLAVALVLNFAFKYKAVLNQSNDSGLPVHSNSTAFVGVQSVSFRDGAAQLMNQQQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U077</accession>
    <name>A0A1Q5U077_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U077"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="55" mass="5925" checksum="1BE9BCE5684F0E08" modified="2017-04-12" version="1">MKHFGAMPPASTLDESIAVSSQDDGLSPSRGVRCQYSTSDEETKNPPVAVVSWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U193</accession>
    <name>A0A1Q5U193_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PENSUB_6238</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U193"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U193"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="OKP06248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="732" mass="82243" checksum="DB36EDB12DA66FDC" modified="2017-04-12" version="1">MDPTVPQSATAETTQAPSEVDLPKRDAANGSPAAEEPPSKKARIDEPEKSEDERDSRRNRGIAPIKAEYLINSTPKPVPDTNTDDAAEAASHTERDDDKKKGKKKPKGQNTNRSFGSSKDAKGLCASRMFSPEFSPEECQFGEKCRFEHDLRLYLKEHKREDLTTFNGICPVHEARGTCYAGWRCRLVGSHSMERETADGTKELILLEDEERKAKAKPLVPFATREGLVNIISYEDKVALSRKREHTPRANQYNDWLNKVSQELEKELHGRLKNEAIVPKSEETPQTNGDAEKAKEELEDNRAQFTEPPFLASEKRRIYFGPETPALAPLTTQGNLPFRRLCGDLGAQFTYSEMALSMPLIQGNKSEWTLIKGHESEMLPPTITPGPNVVQGYDNSKDFRYGAQITANKPFQALKATEVLSKYTPNLRVIDLNCGCPIELVYRDGAGSALLDHPSKLEKIIRGMNAVSQEIPITVKIRMGTRDNQPNALKLVERLVLGGYESSLLDVGPPGAAAITLHGRSRQQRYTKQADWGYIAETAALIKRLNEKTDDLTDTIREADPRYLPNGGRTYFLGNGDCFSHVDYDDHIKNAGVDAVMVARGALIKPWIFEEIQTGQYLDKSASERLAYIEKFAKYGLEAWGSDEFGIGTTRRFLLEWLSFAYRYVPLGLLEYLPPHINDRPPAWRGRNDLETLMGSGNYKDWIKITEMFLGPAHKDFKFEPKHKSNSYEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1E1</accession>
    <name>A0A1Q5U1E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1E1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1E1"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="42100" checksum="A1B5503B358ABD6B" modified="2017-04-12" version="1">MASIHDLNRPPNPFWDHLAASFEDHPFFAPRGHHHPPPPFWGWGNHHHPHRHHHHGPPPPSFWGWGPQDQEENHPRGSETPRAQTTEPAAGPSSSNEKSRDAEKGATSSSEVETENEKRPHGRCGKGKHHGRGGHHGPGRGRDGRGRCGPSRHEHPGFGPFGHHGRGGHHWGGHGGRGRHHGGPPPPFGAEPGFQNFDFLRNLASQFGIQLNGPAPEGVDFVPSVDVFDTPANYIVHVSLPGANKDDLSIDYDPDESVLRLAGVVYRPGISEDLHQALALEERTREVGVFERAVRLGTHEVPAAISIHDISAKLEDGILNVTLPKIAPEPELKKKVVVEDGNIMNEKDTMQMDEKASVTMTPSESDESDFDDGETKDYVKVPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1G6</accession>
    <name>A0A1Q5U1G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1G6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1G6"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="735" mass="82004" checksum="D5F97EB663144D7C" modified="2017-04-12" version="1">MESPDHAASRRLDHVVKRVSRACLHCRQRKSRCDLDSNGNPGKPPCQRCVREHRECVLGGSNRGGRRIRKNKIKNFTPAQDPSPSKDSEETESPATSEVRRAPSASYPGPVVFLPPIPPASTTAGSAGASTSVAVEDEDEASIDSVPRNPSDAWQCLTGIATHSAETAPEGRASTHVRTDSMSTYNGLRTGIVSDYNVPTTGIRAYRLVQSRSLDPGTVWQLVTRYAENFHPYLPLVPRKYFERSALDDFANNEKHLLTAVLTIASKDLVDRPEIHEYCSKFMHELISGIAAGAECDVEAVEALLLLAEWEPQGLRPRIERVGRGEEDRAAWMHVGLALRSGYFIGLDRTSFRGDPYGDQESEARRRLAWASCYVSDRLISVRIGRAFWSRGPGPMTGLSSQDFPSLQPAKEGDEDYSKIYQAMLDLTQLYGNVHEVLYSGMRTSNQMMLMGDYVKYVDDFRLAILRWKSLWGPLDCSPPMRATLQLSYEYLRLYTTAFAFQAAISQSLAKPKTDRSTHREQLRSTFKNVASMQDSRFIYESVDAAKAYLTILVDSVDPERHLHFMPLRFYLYGIYSAVFLYKARSFGMMVPSEEAKVQGLVARTTEVLRQASAGPDDIGSRYSRLLELLWRTKPSMSSANTSAESQQNSDFSMQTALANPVTDPTYMDFSPANDFSWLDLEAVGDYVSGDQIPGGLLGLDTFQNGSDPYQPGQDRSQVWQPSAWLGDMSSNLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1M1</accession>
    <name>A0A1Q5U1M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1M1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1M1"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32396" checksum="61337B4EB9B1F1C5" modified="2017-04-12" version="1">MSLMLSDNLAPQPLTDVFTDDTCIDRRKCHRTVPMKVLALGVGRTGTASLRKALERLGYTKCYHMMCASVENPPDCLMWHDALNAKYNGVGEFGRKEWDQLLGDCQAVCDWPACAFAKELIEAYPNAKVILTTRDVDPWHASVMKTVHWRVSDPEHKFVSHFSWAASMYYPMLNKFFETFFRGDFPGKGKQVYNEHVAEVRSLVPADRLLEYNINDGWAPLCEFLEEEVPDTPFPRGNDMADFYKRCSTRNRHQMMNAALQAVTMGGALLATGFAATIAFKRFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1N7</accession>
    <name>A0A1Q5U1N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein IST1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1N7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1N7"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="42815" checksum="B1EE5A4E9B40AAF1" modified="2017-04-12" version="1">MPPSAQTTRLVSTLRLLIPRLRLLQKKDTASSIVQRRELSQLLSENREASARIRVENVIATDIAVEVMEMVELYCELLLARANVLDQLAFGEKGTRARLRAKELLKKQTQAQTGEKATTAAPESSGSRFGFSWLGGSQKKEASTLAATSSLEGAGELSEEEIAYMDTALDEAAVAIFYAWHRFPHELRELTMLRTMLGERYGKEFMTMAQDNKVDTVKVPDRLLKGLRVRPPTQELVESYLREIAKAYGVDWPGGEELDVQEELGNAPPEFVDDAQGDGDEAEGDDLPQTPRKQSADPASRPNLTEARRASETSELNKATPPRGPAALQGRSPVSVAPPAPRTDNPNPRVKVPGSEEEGGAAKKAGKATFSGIPELDELTRRFADLKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1P3</accession>
    <name>A0A1Q5U1P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_6398</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1P3"/>
    <dbReference type="SMR" id="A0A1Q5U1P3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1P3"/>
    <dbReference type="OrthoDB" id="4341621at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="14">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP06408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="103" mass="11356" checksum="E549A008C50807F6" modified="2017-04-12" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKTFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8V0</accession>
    <name>A0A1Q5U8V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat domain-containing protein 20A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8V0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U8V0"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="29500" checksum="3651C9C6DE332514" modified="2017-04-12" version="1">MVSHLSSLSQEEVQAFSSELIRAMNENNKSKFDCLLSNTAYGVSGYDHYGRLPLTCAVQHNRSDYVKALLDRNANVNRPSLEPLYKGFTPLFWAVAKGSEEVTKLLLDAGASVDSLSDNRTPLFLAVQYKDPKKIELLLRYHANPHAVCAWRRGYFESPFSLAIRLRFAEASSLLLEAQFHHLVSSLNRSTTDKISIHKNSVLLMQERLETLAKRASEESPLEVERTKIEKTAPIIHRGIPSFDWTVDIKAEVEHWNFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA46</accession>
    <name>A0A1Q5UA46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000540">
        <property type="protein sequence ID" value="OKP09348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA46"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="684" mass="79585" checksum="2DFBEFA0921097D5" modified="2017-04-12" version="1">MDNGENTRRLKQGMKIQGCRRLMQNNHVPVIVPQADWNTRVRPRSRDDINFWLDVDPDYQLRAQDHESLVRAALSNLSIQDQWWMADVYVVDEDDDHDSNPDTVKRFFRSLNERFSNDRRPPDGLIYERIRYYEGYLDGPMDEWAAKDWWAMLETAPGSKKGKYLRAFLKHPQFPQRLDSLLVIPGLWGGMRIGLLHKLLAMHCDETFLNIVGNRPDRLALIDGATVKLLQSRAPRISPRDREYLETKRKSAELFSNASPSLREELWQQLQQIDYPIPTLETFFKDRSYLEVGQSVMKQLYSPDPQRPLTVDQRVCELFDTDLPVTSTVSQQMLGHDLLEFWRFSFQYGFEMTDHQRRKALNQASVESTPSLVLEQSAVPDKMRIWGHFCQIIQSRGFRPPNRFVAAPRAQLPDPDACDFPDIGLEEDVEVEKRSGKPFSNTIDVDRHALSAESLRRSWTAPQVTAGFLRRSVFKAFFSYLIRDGQDFSQALAADITLINSDEYTRDFEYQNADVSIRDAEIMSRIQSTSEPGSSVETVRPQFNTTAEVHQGVVASLNHDPSYFSMRVTIGNHEPRTLYLPNSAEFIRSFQEGLLQHFFNVKEPDGRFIPQEDCYTYYLLHPKETLHAQYYMLEPTISPESNDRNNWTDPIRHRDEERLMKRAEDWMKEVVHYCHQNVGFGIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAE7</accession>
    <name>A0A1Q5UAE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAE7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="534" mass="59763" checksum="907A06C90198DB13" modified="2017-04-12" version="1">MADDISRNNNDRIEVEIEKERIENLEHVAEQRNVVPHIDPARRVVVEKSLKRKLDARCSLFVLIYIMNYLDRNNISAARLKGLQEDLNLTNTQYSTCLSILYVGYILMQVPSNMFINRIQRPSIYIAIAMTLWGLISTCSGLAGNFGHMVAIRFLLGFVEAAFLPGALLILSKWYTRRELTTRNAVLFCGNLISNAFSSLVAAGVLSNMDGVLGHAAWRWLFWIEGAITMTIAVSAAFILPDLPTNSRGFTEEELLVAQLRILEDVGEADTDSEEQSPFTGLIMALKDVKIYLMMLAFTAYVVGLSFNAFFPTLTGTLGFAYVPTLLMSAPPWVFACIFSLVNAWHADRTQEKVSLTPKPPSPSQTQSTQLTNPSQIWHIYGPIFMGLVGFIISMSTLNVAARYIALFLQAGSYAGFIVFYSWISSSFPRPPAKRAVALALINAFSQLGNIAGSYVWGLKENGYRKSYGIVTAMYGITIVGFWIFRMILVNLNKKLEIKEAEWDAQNSEQQGDVAFMESADESLRMRKGFRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBC0</accession>
    <name>A0A1Q5UBC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000451">
        <property type="protein sequence ID" value="OKP09775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBC0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012615016" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="259" mass="28031" checksum="F52FE2588FEA3658" modified="2017-04-12" version="1">MLPPFWVLAWSFLQSCCRGYEYSNATDASQIMFNWNIAYMSAPPSALISLRPPTFLVKRVQYLGNVGDPYGSNIIEVSAEAANQYKYVVRFEAPSNGRSWTVSIWNNFASDGHLGGWLGNACRTFTLDRGQVRYIAFDDNSQGGWAAASGSSIPVDRDGSYAATWGEFDFGSAINFGRSAFVVSTIAAEKAGLEVQGMRICDVHTDTCSSVDARSAAVHNAYTTTVAGNAKMGGTIRPGPARLAVSIGYDEFPLPENRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBD4</accession>
    <name>A0A1Q5UBD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000446">
        <property type="protein sequence ID" value="OKP09792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBD4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="58"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="200" mass="23400" checksum="B3BEDE6A683F2C67" modified="2017-04-12" version="1">MEPNAGWACANSHTKPVELIPCELQSQRSRQKRRALKRPRPKPTPNPPAPLRQTILRVSNRDLLRQYYEKAFENFQQLNCRAIAKSYIKLLEPRKQVNYPYNGRKVVSGIIQQIDTELTKPGWWPAGTIHREPDHLLKSDTHGVTADKLRRASLDLRRYITPAIRLQVLDEIYFVRQMEEQFLEGEIGRFIHAIATRSWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCB9</accession>
    <name>A0A1Q5UCB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCB9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012298869" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="575" mass="64301" checksum="ADEAD53DD2C6E982" modified="2017-04-12" version="1">MKLLAVVAGLIVAAESAALAPLGPQLQNALQSVLGLGKSNPSKPPSILFVITDDQDLELDSISYTPLIEKHLRHKGTFFRNHFVTTALCCPSRVSLWTGRQAHNTNVTDVNPPYGGYPKFVDRGFNDNFLPVWLQEAGYDTYYTGKLFNSHTVDNYHSPHVNGFNGSDFLMDPWTYSYMNSTYQRHREAPVSYEGRHTTDVITGKALGFLDDALNGERPFFVAVAPIAPHSNVDPRDLEEGKIKMTAPIPLERHAHLFKDVKVPRTPNFNPDKPSGASWVRNLPKQNQTEIDYNDHYYRSRLRALQGVDELVDSLITRLEESGQLENTYIIYTSDNGFHIGQHRLPPGKTCGFEEDIRVPLFIRGPGVPEGYVQDSVTTHIDLAPTIFNLAGIPPRSDFDGTAIPVTPDFGGTRHEHVTVEFWGRAVMEGTYSELGPGGSTIIPNNTYKSVRLLGEGYNLYYSVWCNNEHELYDLSEDGPQILGRSLTQAIARLDALLLVLKSCQGATCIDPWNVLHPEEPVRGLRDALDKEHDSFYRAQPQVSFDWCDAGYIIEAEGPQVPLTSRYGVSWDVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCG6</accession>
    <name>A0A1Q5UCG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000388">
        <property type="protein sequence ID" value="OKP10150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCG6"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="224" mass="23895" checksum="922D955D29D9FB81" modified="2017-04-12" version="1">MFNWNIAYMSAPPSALISLRPPTFLVKRVQYLGNVGDPYGSNIIEVSAEAANQYKYVVRFEAPNNGQSWTVAIWNSLTPDGRLGGWLGNACRTFTLGRGQVRYIAFDDDSHGGWAAAPGSSIPVDGGGRYAATWGEFNFGSVINFGRSAFVVSTIAAEKAGLEVQGMRICDVRTDTCSSVDARNTAVHNAYTITTAGNAKMGGTILPGPARLAVSIGYHGFSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCM8</accession>
    <name>A0A1Q5UCM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9493" checksum="A25330D3B8052CA9" modified="2017-04-12" version="1">MFNQMLIRMAGVSTERAEAPRVPARNLVLDCRQWLRCIETLGRDSVLLWDAGIYPGEPWVNCNFFSESRADAEVFGFGITARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCN6</accession>
    <name>A0A1Q5UCN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrosoguanidine resistance protein SNG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="41"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="393" mass="43918" checksum="D8924D241EDF46CD" modified="2017-04-12" version="1">MFNEMSDKPEVEAVPAVSFFDPALKEVRRRVYYQWCRTLSILCIFVLAVLSIFWGSQYSTESKYTELKVWVVDFDGQTDDYRASNPLVGPAVVNTAKEFIDTPALHLGYIIKNASTFDNDPWAVHQAVYDEHAYAAVIINPNATALLRAAVTQQNTSYDPTGAIQTVIISARDENTYYSYVLPDLTTFQSAVLASFGPQWIQTLTTNKTNLTTIPPQAINPAIGFTNIDLRPFTPAVAAPAVTIGLIYLIIIAFFNFPFLMPIHAQLIKPSAGNPPLKIPQWLIWRICSNIAAYFFLSFFYSLVSLAFGIPFSNSPAPDTVSANNPNAYGKGSFVVFWMLNWVVVEALRTILFGTHSRIGLDFAVLFIWIAVSIAFFPVATFIMRWKMKRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCV5</accession>
    <name>A0A1Q5UCV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000362">
        <property type="protein sequence ID" value="OKP10305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCV5"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012004819" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="29070" checksum="ADE9E3E6911FC87C" modified="2017-04-12" version="1">MSSFWDSQTHLAIRAALFLAVLLPSTTAECYWPNGDAAGSYVSCPDSKVCCLKGEACLSNGLCYAARYNIAYRGACTDSSWPIADCPHACYTTITDQWANLLTCSGTARGNFTCSTAVDGKTACEQNVETWVWEGDSGVNVTVAQNGVSSISSTDISGSTTNSTSSSTNIPSTTSSSPSSTQTSVSSSAKNTSYKSVLDLGVGLGVGLGVPLILAVSVLMFYCLRVRRQSKTIGDYQDATRNLTGYRPSQVIGTREAPCEPCELGAEKHTPELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDJ3</accession>
    <name>A0A1Q5UDJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor TBF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDJ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="646"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="765"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="471"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="832" mass="91731" checksum="94812C0F1E52D243" modified="2017-04-12" version="1">MAESRDERPSFDEASALPSFPDDEGPFDEKPIHLLDQDDNASPPATKKRRTDDAAGPDDEISMDPQFPGSDQHGPGHKIEEELANALAEGNANDLPLTNGTHENLGSDPSAAATVAQDGTSSSNADVNSLITDILDHTERQEETVAMGPQEIPPSGDFPGAKGYAFLNLKANSHLKIQSLPILDNLSTQILSFLSKNTYQDLTAMVSEPDSENGQAYATMRSLFDHTKRVYTIKRSFLQSTDIEVTDSSQLDVLRKANLASFVSSIFGSQEIGFAELNEHFLDVFVPEGGRLLKVQAALYLELKTQAFIAAMNTKSRTRTQLLYELFPDDMEQRLLARRPGTRQLAPSETDFVNRLTSRRDILLNDINNEEALKALPDKYHWEDFLRDLSSYIAKNFDAINTQQGKKPIKGRQPSSSNGDAQETPSTTHQGQFPVNQPVEVPVDRNMHGDLVARAARAAQIALQGHGLRRSQQQSQMQHQQQQPQPQSQASPSPSQLPALPTHQQQQHQQPPQQQQPPQAQPQPQHTAQGDNQYLHGYTAAQQSGQPPQQQQYHHSPTPPGGYQQSPGGLAFQQSPLQANFQQYNPNAAQVMQARANGMSPGNHGYMPGIPHYSQSQPTQVLYERARMAASAKSSPTSRKTGLPSQRRPWTTEEENALMAGLDRVKGPHWSQILAMFGPGGTISEALKDRNQVQLKDKARNLKLFFLKSGIEVPYYLKFVTGELKTRAPAQAAKREARERQKKQGEEDKAHVEGIKGMMALAGAHASPVGGHEMSASPSLPPDANAQSMFDQTAEQNLMQTLSQEVHGSQYPQQHPPPTPDHHIDPHMQLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDR2</accession>
    <name>A0A1Q5UDR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="467" mass="51653" checksum="DA7E18B28CC901DA" modified="2017-04-12" version="1">MLNSPFQGIFGTAQAQEYFSTFFHPSTPILGAIISTYTAGGAIGCLLSWPIGRWSGRCGTLRIGSLVAIIGTVLQTAAQDVGMLIAGRLIAGLAIGIIYFAIPQYQSELAPPEHRFICSGSIVGLHAQFIGFGYALSNWIGFGVYYAKGQFTVFWALVLLIGTFFLPESPRYLIEKGKYEEAYKLLQKLRKPEHLEMTKKEFVQIRDQIVWEQENEESSLIGILRKPSYRRRLILGCGIQIGQQICGISAINYYQTIMYKSLGIKGPTVLALAGVWGILGPLSNLLCLAFIIDRVKRRTILFWGSIGMGIDIAIVMIIVAVFSGGPNKVANGFGILFLLLFDIIFSISWNSGCPVYCTEIFPTQIRTTGGAIATFWSFIIQVILAQASPTALTNVGWRYYIFFIVMNIVTAACVWFFVPETKGKSLEEINEVFGDSFVTVHIDEYVAEEKLDQAVYQHKEISGQVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UET4</accession>
    <name>A0A1Q5UET4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UET4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UET4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="202" mass="21367" checksum="1DFEAC5969B26E05" modified="2017-04-12" version="1" fragment="single">STNMQVLVLGGHGKVARYLTPLLLNRAWNVTSVVRKAEHEDDIMSLGEGRKGKVNVLVSSLDQVKSASDAQKILDTVSPDYVVWSAGAGGKGGPESTIAVDQEAAKHFLSASFASAYVTELDGDAPATRKVQLGRTAGRGGVTREDVAIVADQLLASADAKGWIDLINGDMPVEVAVEKVGNGKYDAVEGEDVEGMVRRFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEY5</accession>
    <name>A0A1Q5UEY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEY5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="10873" checksum="F1211100019DC92D" modified="2017-04-12" version="1">MVQEASQSETSPGNLLLEVIAKQVKCHRPEVNSDSSIEGSDLEYYYTDSDSEESESDGDDDDYDDEKYQSEAEFNDLENVAPSAEDVPREISIKKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFJ1</accession>
    <name>A0A1Q5UFJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_3267</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFJ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFJ1"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="136" mass="15114" checksum="68016FB89998BDB5" modified="2017-04-12" version="1">MSSSAACIFCKIIKGDIPSFKVFESDKVFAFLDIQPLSRGHALVIPKYHGAKLTDIPDEDLLEILPVAKKLAIASGATDFNILQNNGRIAHQVVDHVHFHMIPKPNEHEGMGISWPAKESDMDKLKALHEEIKSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFY9</accession>
    <name>A0A1Q5UFY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFY9"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF65">
        <property type="entry name" value="HYDROLASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="104"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="409" mass="44336" checksum="B461593B24448BDC" modified="2017-04-12" version="1">MALYNQTVDFLSESWANQRTQLPLLAVTGASFTLGLLLRSLFKGDKHKDAILISPRSTVLPGLSEEEHRKLPLPDDVLPGARDVASPYGSIRVYEWGREDGPKVLLVHGITTPCIALGGVAHALVDRGCRVMLFDLFGRGYSDCPSDLPQDERLFATQMMLALTSSPISWTGAGSGKFCLVGYSLGGGIAAAFASFFPRLLTSLVLLAPAGLVRDSQISFQSRLLYSGGLMPESLLGYLVGRRLRAGPLVAPKKNKNEKLNAADALTEELPSQTAAEIQILSREYPHINIPSAVAWQVNNHAGFVHAFMSSMRHGPILGQRQWGTWARLGEYLSAQNSTVSDEKSEKGLPSHKVHILCGNTDAIIIKDELVTDATAALGGNAVFKFYDAGHEFPSTKYEEVATYIAKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG92</accession>
    <name>A0A1Q5UG92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG92"/>
    <dbReference type="OrthoDB" id="160054at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012118082" description="Small secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15695" checksum="3FD3432887F1A74A" modified="2017-04-12" version="1">MRFTSLLALVATPVLLVTATLYPATSNTKGYKPKSLNCSASKVSTAIQAAECSHNTRVSGTQTFAIFQTDHQYDSSNGAPYGTCSAYTCTAPTFSELEADDDYWAFYWGDEDQGQSSGVGTGCIKDPSSGECGCEDSDGVFVVGSDSCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGI6</accession>
    <name>A0A1Q5UGI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGI6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013338911" evidence="2">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="526" mass="51466" checksum="353BA9C7D3E350D4" modified="2017-04-12" version="1">MKFSTSITLASILAVGSAVPHVPRHSSSSSGSVPSSTGLPSSSIPLASSTSISVSVPSSSSSCSETLSSSVPYSTVSVSVPTITSTISASSSLVPSSSGVPSSSGVPSSSSVPSSSGVPSSSGVASSSVVASSSSVASSSGVPSSTGIASSTRVPTSTAVPSSTSVPHSVTSTQKMTTSTIYTTSEVTITQCATTVTNCPAESTTVVTSTIPVTTTVCPVTETESESATASSTSVKTTPSSSNASQTSKSTAPAQGSTTTEEIYTTTTICPVTETHTSGTSVITSTYSTISTMTVTPTRSTASASASAQGSTVTEEVYTTTTICPVTATMTSGTSTYVSTYSSISTMTVTPTRSTSSTSSVVITLTPAESATTVTTFETTTICPVTETMTSGSSTFVSTYSTVSTMTMTSPIAPSSVATSETVPAGSATSVVVPHGSSSVVPGSSVSAIPSSSRPAGVTSTPLVSTSVATVGASSTMKSSMQPSSVPTTATASSPSQSPAFNAAVSVGASSGLWMAATAVLSLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGR1</accession>
    <name>A0A1Q5UGR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGR1"/>
    <dbReference type="OrthoDB" id="4425169at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23904" checksum="EC816501759E49EA" modified="2017-04-12" version="1">MAITELIFPKIKNDQASIDEIERDWPEISRRLTHPNPGVLCAYRGWVLTENGRNVGEEHREFLLFEWNRVESFHAFVVSEQFVNFAASIRHLVNGPPTLQVFETNFGPGDAASASSVEIYRVSVPNAENAEAALKTWEEISRKAQETYGDKVAITYGKSQNLEEEVIAGIIGWSRPEDCVPATGGAVLADSFESLKTLGGLSHITVGIDTMELPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGS2</accession>
    <name>A0A1Q5UGS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGS2"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384537" evidence="2">
        <location>
            <begin position="17"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="202" mass="19630" checksum="D3E9C407E031C597" modified="2017-04-12" version="1">MHKFFAAILFAVSALASPAPDTSSAIGTSDSPANLDLGSISSYAAGLEVAIPSSILTVMETAIPASWQDEVITDPAFRSSVASAAAAGTYPAWYNELPSSVKAWASSNFDAQVLGVPSTTKNVASETGSTGTQSVSNAVQTTSSGSSAAATSVASSRSGSGSSSVSASASPAKSTGGASLPTSGAIMGVAGVAGVLSLAVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH57</accession>
    <name>A0A1Q5UH57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH57"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH57"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="465" mass="52935" checksum="F758FE2463341F11" modified="2017-04-12" version="1">MDHFPNDVLLRHSKTCKQKDNRPLGPVKRGRKRKACDTCALGRVACDGDSPCETCLFKGLDCSYSCVKQQQVTSQDTYDQGTSELHPPDPATNESCVKTRQSSQRRISISFLLNCPDDFHRRLAEQHEDDLFEATNLSGQFTETWPFLFHAFINPSALDTTSQHPDLLYGLDDYPSLSRTSEELFRCLGQARLPYTSDIESDRTRARAFVSEASIMRFVNAFFQYAYSSNPFIHKASFNVNTASRYLVLAMLLFGLTYASPENASAYNGYLHVVEFLIFEGPEFQQLLRQKKHSVISKEIIQLIQAAILVIELQGSQHDVEIKRRIRVQRLPTLISVVRLLDLTKVVNDIVLDGKIATLEESLHCVLFDLQALASIINIPEAFKPVERALDRWKLIWDSKYAELQLSSMGPSGFMVHALEYWWLAKKLVKHPQIFSMRDEVAADSTVAFREMTKSLLSQSLCYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH78</accession>
    <name>A0A1Q5UH78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">penicillopepsin</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_2603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH78"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH78"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013089805" description="penicillopepsin" evidence="14">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="85"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="391" mass="40111" checksum="E5685A919E60957C" modified="2017-04-12" version="1">MVVFSKITITLAGLASIASAAPAVKTNSKFSLKQVARPATKTTNFAAAYGHALSKYGATVPSHVEAAAVASGVATNTPVNGDEEYLTPVTIGGTTLNLDFDTGSADLWVFSTELSASEQSGHSVYDPSTSGTELSGYSWSISYGDGSSASGNVYTDAVTVGGITAPKQAVEAAQTISSQFQQDTNNDGLLGLAFSSINTVSPRAQTTFFDSVKSSLAQPLFAVALKHNAPGVYDFGFTDSSKYTGSIAYTSVDSSQGFWSFNVDSYKAGTRSGGGFSGIADTGTTLLLLPSTVVSAYYSQVSGAKNSRTAGGYVFDCSAKLPDFSVKIGSYTATVPGSLINYGPSGVGSTCLGGIQSNSGIGFSIFGDIFLKSQYVVFNSAGPKLGFAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHL3</accession>
    <name>A0A1Q5UHL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHL3"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="79"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="37117" checksum="F40B768FBE9EB088" modified="2017-04-12" version="1">MSEGTLASAVAVPEQDTLRQSPELSTKRRQSSVSEHETKRRRLSSQGDISPNARRQQHSPQASAPDRPAERRPNRQGREEDRKRGQRLFGGLLGTLSQSSTSAAQKRRADIEKKQQDKLKSQADEYDELKKRRRERRDEIRRKEKPFYEREAMQTRHSNLIATAHFLKTRTEPVLYYKPWQLRSGGEAIIREQIEEAEATVAREVAEFDARYPPEAFVYEKLEPISAEAAGQQGEPEAQQEAKPTAQPVSEEAPTPKPEAEADAQEAKETSDKKDSEPSEEKPSEPTPTSTVPMSMGVDGAADSRDAHRAAHDDDGDEMLEDNEDTVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHM9</accession>
    <name>A0A1Q5UHM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHM9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHM9"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="83"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="571" mass="63090" checksum="067670D5B7F2E783" modified="2017-04-12" version="1">MRPTTITRLVVRSGLLVTSRNGGGQRCLTMLHPPKFENEKMLNYAKGSPERAELTKTIQKLKSEFPVTIPIQINGVEIQTKQSRAQLNPSKHREVVANYASATPDQVNASIDAALKAKPQWEATPFEDRAAIFLRASELITGKYRSELVAATMLGQGKNIWQAEIDAPAETADFLRFYIQEAWALYSQQPQVQPDGQWNKMEYRPLEGFTYAIAPFNFTALGATLVGPAALLGNVVVWKPSDSALHASWLLHKILLEAGLPKDVIQFLPGDAEEVTNTVLKRPEFGALTFIGSTATFKGLQKKIGDGIGQGIYNSYPRVIGETGGKNWGVVHSSADVKSAALNTIRAAFEYQGQKCSANSRVYVAESVWPEFQKTLVEETAALKVGPVEDYANFVNPVIHERSFDKLNKFIEDAKTDSELELLVGGKASKKEGFYVHPTVYRTSDPRHEIMSTELFGPILGVYVFPDSEWEQTLKLIDTTSRYGLTGSIFAKDPYASRQAQTILKHAAGMLYLNSKCTGATVAQQPFGGSRDSGTNDKTGTMAHLQRFVSTRTIKEEFVPLEKVQYPSNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHN2</accession>
    <name>A0A1Q5UHN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHN2"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="746" mass="81649" checksum="FD7DBCA8C0FFEB55" modified="2017-04-12" version="1">MPYQRAISPFSLETYEPSADDITSDELPASDDELTEAERAAKRQRIEKLAESYLQGKPLFILSASLKGPFEQGWRNPWKKDRKAVVSRQAKTRGKRVIQNAGRVVQETDLRHPKYREDLAVAAPSPAAAISRIAQSPNAQGLNAGSPVTSRSAQKRPLQAAIHDEQHRVTPRSIKKPKETPSWRTNDHSFAAGGPADWLKKDRKRLNFTQYEPPSSPTSKIVSRQAENKARVGAMRTMELRPPATTSRRRISITPAVDEGTRTAERMDISLEGSRVAAATERNHDQIVVRSLAPGPQSTHGSSPSVEIPVASSFRVISSTSQLPRFEYRRWHQTNDSSQAGQQSPIKAVSPAAIDTSVKKPVTVSGAEKVQEDLPSEGVVAEVQDAPAAGSSENASAPSADIDAPAQIDQPVVSDAPVVTEQLDDAVLEQEDPEEPNEPLERPVDDDPKEASEAELVQTSKDLRFADEAGLSTYIEEEDQPQTEQNTYENLPSAQHVPVPPGVSDRIPSLYSTAMPRTNPDQNTEESSDTQLSTQAALLHAQRSFQEDLDSPEPEFIYPAEPEDTVMGPEEESILAQETPYNGPQASEAVHHASLRGYSKERIQAMSTQCMIDAVTPYIFSTEKKSKAFRELSPDQPKERPEVPPDLLVVSPRMPSPSQDHEYHRAHSSPHGPDPALTHRSTTQGTALPFALSGSTPTTAQDGQGAPPGVENFDLSQAIADAGSWLQQSFDFMKDIRRPSQPARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHV7</accession>
    <name>A0A1Q5UHV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHV7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="98"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="531" mass="59150" checksum="8ED48D90C79C1588" modified="2017-04-12" version="1">MAATLTPDANTESPLYASTSESLWTDLDLQLSSESLSFLDEVFMQGFAPSESIANINDQSNNCSRNANEIMEGAMANQNPYELQGIDSGTLEAALTGYFDFASLVLPIIHRDAFMADYESRQSSSALVFAVACRGCPFISVPDKWKLQQQFACGFRLAFLEAQNDAPSKQTIKLDELEALVLMVDFTYESDGNTATALHSQLGALFLTHESLVLMTLQYRILSPPALQRAAERKALLLWHVYGLDAFYCLDHGVMSRIQEEDIEDVKSTGSFTGHETRSYLDTMLSLASIARRITRKICSPGAKRKGVKLQDVENLYEQLSKWGQDSCPSRLRVTGNISSDLAERKRDSQPSTTVSTNLLHRTVISLLELNCYMEIERCLDIGVQDRASAEGEALELRIRYETLRAANKIYQAIECMETVKDCGQVITGRNRYSLVDLSPGILRNMCAGASYWFCNHAQKLLHQQSLLGAENSVHTQHCKDLSRQRAEDYLNKATKLRDTAATAVSHMDTAEVVSRVNEQLEVLKVLVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIC2</accession>
    <name>A0A1Q5UIC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cocaine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIC2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="21729" checksum="B1021BC850B2047A" modified="2017-04-12" version="1">MPTTAEDHQSKHPDLEWHQLPTPEAHPRYTYRGFQPGRSILTTGHFRSPGWRPFTADTILDNDVSIPMRDGIKLYADIFRPCSSEGGRQTVPAIIPWSPYGKTGNGCLNYDNIAPFRVGLHLNQTSGYEKFEGPDPADWVPRGYAIINIDARGAGDSEGNMVFWGQQEAEDIYDAIDWISKQTWCNGSVGMAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIQ1</accession>
    <name>A0A1Q5UIQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIQ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="25035" checksum="9651C9CA44FCA010" modified="2017-04-12" version="1">MSARSWSRMLPRKSFFDTLYNSNSINSTRDGFLTSRSAELVNPRHHMVLSDTVWQDFDAETLAGMTDSKILSSFTSGFFGGFVFGMEDFSQDTQAPELWRRSEVPVNELCDVGTRLFGVFQLLDKHVPESPGSPLSYVDYGFGSDKYSFAGCHRFSITRNPTSSDKISEVEQPEARIRISLEGFTCNPQTNKSPVPEVGKWFHALYARALFANGIQAVLESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJB8</accession>
    <name>A0A1Q5UJB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000202">
        <property type="protein sequence ID" value="OKP12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJB8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="8950" checksum="0EF4DD85EDF35836" modified="2017-04-12" version="1" fragment="single">MTGFPQLKYATNFVRHDVDVRSKAEILDEVISHNNLMGGAVNNAAAAAEDASTTTTAAIHDADDKMNEEAQKLSSQLFQYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKA0</accession>
    <name>A0A1Q5UKA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKA0"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="56"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="320"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="570" mass="63335" checksum="0823C516511DAE53" modified="2017-04-12" version="1">MRNPFDLDENSVDGDSEPPTDLEFEVDVRPHQTDDGERALLQDEEHHPSDLKERFIGTIDQGTTSTRFIIFDCTGVPIAKYQTEFRQIHEHPGWHEQDPYELVESVYICIEEAMKSFLALGHSRSDIEAVGITSQRETALVWDWETGEPLHNAITWTDTRTVNLVRELKEKPGAEDLVNICGLPLSTYPSSVTLRWMLDNLPDVRSAYDDGRAAFGTVDSWLIYNLNGGPQNKRLVTDVTNASRTMFMNLETLQYDDRLLKFFDIDRTKIRLPEILPSADREGFGEISEGPLEGTPITSCLGDQAAALVGHCAFTPGSAKNTYGTGCFLLYNVGEKPVISKHGLLGTVGFQLGRDRKPVYALEGSVAVAGSGVSFLMNNMGFFRDSRKVSDLAATVPDSGGCIFVTAFSGLFAPYWIDDAQGTIWGITHHTQRGHIARATMEAACFQTKAILDAMEMDSGKKLTELAVDGGMSNSDICMQTQADIIQIPVERPAMHETTALGAAIAAAFAIDVWKDFSDLKHMNRANRATFEPHITPKESARMYKRWSKAVEMSRGWMREEAESNDDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKM3</accession>
    <name>A0A1Q5UKM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="203"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="677" mass="75106" checksum="B561C1E2199C0A31" modified="2017-04-12" version="1">MDGLDTLASVVADHAQTDRRTLLGTSPQFVEGLSVHRTPMMGTRLANPETPSAAPPTPLPGPEFGYSLGGFTGSYEGNDFTSFLDSVPLPSHPFSPAFQPLPLFPPLTYSPVTDYDQSSERGQPSETTSTPSSSVLPRHGAQLPSLQPEGYQTTPKARQPTGFVPVTAQCRDKALASLADYANVVPDPSLPSRHALSRCLTGYLMGFHDHYPIVHKPTLDVDAMSLPLFLAMAALGARYSREPDTSMRLYQIAKPVTLERFRRVFLCGTMPSVNVANDQDTLELLQALLMLISVSSWFINNPPYHESLSIRSHMATLLRKDGINRLPEYDGTWTSWIRRECVKRTKLIVCCFFNIHTIVFDIPPVILTEELSLDLPCTEKEWQAPRADIWQVARTQSPGEPNLQDALSALFTPNSGMERFSSLGGYVLIHALLQDIWVMTKAGRLALSRGYRQGSSIASTPELVSIEQALERWCQCWERNQESSIDPMSPHGPVSFTSAALVRLAYIRLNADCGSARQLQTWDPVQIATSLKDNLRVQRGDRLTRAALHCAHALSTPVKLGIGFVAHSQVALWSNQHALCSLECAVLLAKWLEAVTVQNPNPGLTEQETRLRDFVLEMVMEVQHGVSREWLLATNTRLSAAVTRLWARLFTADYIWEMVSLIGRSLNSYADLLEEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKU2</accession>
    <name>A0A1Q5UKU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKU2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="49" mass="5236" checksum="9CEFB583F93AB7E5" modified="2017-04-12" version="1">MALLACKWDPSHYDLLVLIIGVLVKAVDTADSTTFHIVALEALLLGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL61</accession>
    <name>A0A1Q5UL61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyamine transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL61"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL61"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="130"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="62142" checksum="439A9CA0776FD939" modified="2017-04-12" version="1">MTESTIPEPQETPAPVQPLHLTKAETRETLRNMGISEHPAPLDYNYPEVGRTENPLFPEEYVIETETGLVPQATLEQVRSRASTSTEATRREDFPIDPEKAPGKSTEYVTFTIGDPEHPHNWSRVYRWYITLVASALVVCIAYGSSIVTGGLGLIQEKYNVSLEVAILTCSIMVCGFAVGPLLWSPLSEIIGRRPVYIISLALYVIFNIPCALSPNIGGLLVCRFLCGVFSSSGLSLAGGTIADIWSTEERGMAIAYFAAAPYCGPVVGPIVTGWINVGSGRLDLFFWTNMAFAGVIMIMVGLIPETYAPVILKRRAAKLRKETGNPNIITEQEQTKLTVRDIARTSLIRPITMIMTEPVLDLMCMYIVLIYAMLYAFFFAYPVIFGKLYGYNDGQIGLMFIPILIGAGFSLLTTPVIEKQFKRIYDSRTPTPEDRLIGALIGAPFIPIAFFLLGATSFKHIIWVGPASSGIAFGYGMVLCYYSVNNYIIDSYQKYAASALAAKVFLRSGGGAAFPLFTTQMYDRLGLQWASWLLAFIGVGMVFIPYVFYVFGGRLRAKLTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM27</accession>
    <name>A0A1Q5UM27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="274" mass="30233" checksum="6765E4ED1F8CB93E" modified="2017-04-12" version="1">MALLTTPTYRDVLRNDLPKALQDDLPADLVILQCIAPKKSPKGTQCRRTIGREHVVKIQALLNRPMTYLEGDQDKSYAVLEELVNLCVHSGNKHGERGRDKVEKVVEKYREAIDQHLEAKKCEGNVMAVPELATMPKESFVEAEPLLVTHLSCTEVTMAIKAEGVTYPALPTTHTFFIEDKEEIAAVGSSNEAHPLLQPKNTPSRPLTNPSSPLLCKPLIQQSNPISNTLPSNPLLSLILNTLQHLFVGFISLVQVGWGHVPVETTSGEIKNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UME0</accession>
    <name>A0A1Q5UME0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UME0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UME0"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="6">
        <location>
            <begin position="97"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="262"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="704"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="840"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1185" mass="133472" checksum="CC7E73EC4492146E" modified="2017-04-12" version="1">MSSLSLRHSVVPRRRSRNESGDDSDSSDSVNATPASNSKRPRLNPTEEESESEGDESEENEDTQNDADGSRESSQPSAPRPQAHLGIGPGGYKPGAIVRIKVANFVTYTSAEFHPGPKLNMVIGPNGTGKSTLVCAICLGLGWGPQHLGRAKDLGEFVKHGCAEAKIEIELAGPPKLPSNPVICRNIKRDGNKSSFTINGKSASSKQVLKFVQSFAIQVDNLCQFLPQDKVAEFAALSPVELLHSTQRAAAEPEMTAWHDHLKGLRQQQKQLELENRGDNETLANLKGRQEQQRAEVENMRQLAEAQEKMQVLELCRPVLEYREAHKKFEEVRERKAQVEQEERQLKAELEPVMHAVTAKKSYVEQISSVRAHRRERAEQLAKEASACAQKLENLQNSMNDLDGQIAAEKKSSQKHKSEATQAQQKVNRLKRSLEEDVSEFDATYYNDLLREKRLEQRELETKATAIKQERIPVEEKRKELESHIEEAETQLRSLDSQMGQQEARLQQVSLETLKAYRWVKTNQDKFEKPVIGPPIVTCSITDPKYADAIETLLNKNDCLAFTVQTKKDFRTLQQHLMGQMKLHDITIKTSPSRDYPPPPVSDQELRQLGFDGWAKDFISGPDPVIATLCMENRFSQTPIGLSQFRGEQAEVDELRRKKIAIFVAGSQMYQTNYRAEYNASSTSIKVVGTAKFWTSQPIDTSIKQTLLQNIGNWREEKEEVEQRIQAFRKELENLRNSHKEIDRAIETTEREKATKQSAHTEWLAIPQKISQEESKVKSLQELFAAVREKVAGYRDEQDGLAIQKAEAALEYADAAEALRHACEELVKVEVWHLEAKSDHQTLEDKHAGYKQMLEQKAREVKQLRDEVKERRDRGRAMLKRATEVFDDLEQRPNGEAIRSMVNEVTYSLDKLNADIDSQQAQIRLFVGGNSNIIKIFEDREKQIERLELKLSDFRTKLAEFDAAIKEVRGRWEPRLDALIAKISDAFGDSFARIGCAGQVSLGKVEAEPGPNGEPGGTEFDQWSIQIHVKFREHEQLSILDSHRQSGGERAVSTIFYLMALQSLSASPFRVVDEINQGMDPRNERMVHGRLVDIACDSDGEGAVDENGNPVGGGGGGQYFLITPKLLSGLSYKPGMRVLCIYSGEHMPEEYAKLDFGRAVRKMRAINEQAKSRASGSNSQVDVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UME1</accession>
    <name>A0A1Q5UME1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UME1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UME1"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="17251" checksum="D6099AB9C4301291" modified="2017-04-12" version="1">MPKNKGKGGKNRRRGKNENDNEKRELVFKEDGQEYAQVVKMLGNGRLEALCFDGEKRLAHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVIMKYTADEARSLKAYGELPEHAKINETDTFGNEGFEDNVEFDEDRESEDEKEIDVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMM3</accession>
    <name>A0A1Q5UMM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMM3"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="358" mass="39508" checksum="5DF4FBF2C68586A2" modified="2017-04-12" version="1">MSTSQPHDVYHTVNLVTQILCIPIVSIFVALRFYTRWRFRQSLGVEDYACAVAWGLFMGYCAIGIVVGNHGGGYHFDQLSHETQIQYRKFCYIATILYCPMALFVKIALLAILTRIFAPYRGKVWFIYILLGCLCTYYIIALIIKIRMCYPIPLYWLGELPNGEGSCLDQAAALIADSVISVVSDLIILILPLPLTWSLQMSRSRKLRVIGLLSAGGLATGFSVYRLILVLKDGSSPDASILFICVIMSGNAEGGVGLICACLPVLNVLISHYRKEYSSQKYYNQGSDIQLGERKSGNISQSASRFGKTPNFGDQNDQSHLISFAGTPDASDSIYNDDGIRKTVAVSQTVESADGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMZ2</accession>
    <name>A0A1Q5UMZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMZ2"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="271" mass="29864" checksum="29965FFA7ACBDC37" modified="2017-04-12" version="1">MASTTISAATPSFQIISTLRFDPDLPRVTSHNANDESYPVPAHSPYYLLSYHRDRLINAARHFEWDSALDFLQQGLDSFESFLDGSIPNREKPWRLRIAVDYNGKGSVEVNPTVAMDPLNLLVPSLHSGTQSTIWKVYVDSQSITPSGFTTHKTTARDDYTAARVRAGITSPAETSEVLVVNPDGEIMEGSITTPYFRRHIVGKEINANEAVWVTPPLTSGGNAGTSRRYALSQGFCVEQVITKADMVDGEECWLSNGVRGFVRGVVVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN26</accession>
    <name>A0A1Q5UN26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="16">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_445</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 16">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15 16">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="16"/>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN26"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN26"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="18">
        <location>
            <begin position="278"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP13870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="591" mass="65934" checksum="ACB7B62577DEE879" modified="2017-04-12" version="1">MSEECANPLLLGWIKEWLDQARERNSKGVTVYKKAYESMKACPLAFDHPSQAQQLNGLGPKLCDRLTEKLKAHCQENGLPMPQVPGQGSKRTSDTGVAEQPAKKPRKTKPYVPALRSGPYALLLGLATLGEHADQGMTKAHLIEVAQPYCDSSFTAPPDPTKFYTAWNSMKTLVQKDLVYEHGRPLRKYLLSEEGWEVAKRIQKTLPGASANIAVSTGSNPRTQPSQVAPASGNRSVLNDGDEDIVIQEQPTSRLGLASHMDGPTEPFMLPPGSFTVELLLDTREVRTKEDRDYIANMLIEKGIKPQVRALELGDVMWVAKCRDPTYLARFGEEGDEVMLDWILERKRLDDLIGSIKDGRFHEQKFRLRRSGIKNVIYLVEEFKVTHNDSTSGSAATYQEMAASAMASTQVVNGYFLKKTRELDESIRYLARMTRLLRKMYGAGDSSSDEPQSSQSGTTSKPTSVTVIPSRRISSTKSYLGLMDELRVKDPSVTYGVTFSTFSALASKSNTLSLRDIFLKMLMCIRGLTGERALEIQRRWPTPRHLVEAYMALEPSERETLMSDELQSLVGRKKFSKALSKKIAEVWGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNX8</accession>
    <name>A0A1Q5UNX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal lysine N-methyltransferase set10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF135">
        <property type="entry name" value="SET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G11040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="656" mass="73640" checksum="30B9F63C03327DDC" modified="2017-04-12" version="1">MELVDWIISQGGSLNDCVRVAQDTSRGVHVQVKGDWPEHISKETKVLSTPIGVTMTYFNAIGFQTPQATFPKHGVELPQAFIDAVAVEETFTFFLMGQFLRGPQGFWYPYLRTLPQPGELNTPLFFGEEDVDWIQGTGIPEAAVQRYQVWDERYEQCVSKLEEVGFEGLEEYTWDLYLWASTIISSRAFSPKVLSSVVEASKLAEDSGVSVLLPLIDLPNHRPLAKVEWRAGTSDIGMVVLEEVGPGHEISNNYGPRNNEQLLMNYGFCLPNNPTDYRIVKLGVKPDSHLSKAKKRQVEMFPEVANNKEDHYYIFNVFYPLLGPDTAMEHSIFSPALFNSLTIMHANERERKQIEITESAISIPAAYGNGHSTLAALSQISFELISHIMMLEATGQDRQLQPANLKQTFAQIYRNGLLTLDKAALVIVTWTLARAREHTRGETWEDIKTLLNEHMSQIPEGHFPAETLSRIRVRILERKSLLKKHGELFRLGELFSLLPADMQAASRECFNHVLSQAGQQVSALQTDPQAIFALAICLLIATGRSPQARPHLSSRLTRWVDFLVEQYPMSAVPSATGGAMDQLSQFVQGNQAQSWAAQDGVQWLSEESGWLDSNWLAWSFNVAEAEMMLIPHEPLQVLVTENPGLPKLGCLYVPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPF4</accession>
    <name>A0A1Q5UPF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-1-phosphate phosphohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_14128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPF4"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000013">
        <property type="entry name" value="Glycerol-3-phosphate phosphatase (GppA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="236" mass="25249" checksum="13842F7AA8B008D3" modified="2017-04-12" version="1">MSATETFSAPAEVHTFDGLLSDFDGTIVDSTDAIVKHWHQIGAELGVDPKTILATSHGRRSIDVMGLYDKTKANWDYVNYIEGRIPQTWGSDAVEIPGGRDLLNALDSSSAKWGVVTSGTRALIDGWLGVLGLTHPKYLVVAEDVELGKPDPRCYQLGAKKIGLEGSTNIVVLEDAPSGIKAGKAAGYKVIALATTHSIAKIREAGADWIVEDLRSVSVKGVVDGQVQIEIRNALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPR1</accession>
    <name>A0A1Q5UPR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein KIF21B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_14079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UPR1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000125">
        <property type="entry name" value="Kinesin class 4 (Chromokinesin group)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="49"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="873"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1224"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1323"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1557"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="637"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="957"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="902"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1323"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1568"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1584"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1603"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1735" mass="192402" checksum="1D737A4D34687682" modified="2017-04-12" version="1">MTVSPPASPTGPAPRPISALMRTPRSNSRMSMSSRHGGSRASDEDGKTAVKVAVRVRPPLKPTDPGYELIPQRFQRSMVHVTSPTSVAVDVPQGRKLFVFDRVFPETVEQDGIWEYLNDSVNSFIQGYNVSILAYGQSGAGKSYTMGTSGEQENSGAMGIIPRAAQALFEKLDGPKHARNGSSSTGLRTPQRYSMSSASSFGKSTVEKNWQLKATYVEIYNEHLRDLLLPDSVSATDRGSVTIREDAKGRILLTGLHQVNINSFEDLIGALTFGSTIRQTDSTAINAKSSRSHAVFSLNLVQRKTATQTMSPKEKRMSMPVDSFSGGESVTVDSKLHFVDLAGSERLKNTGASGERAKEGISINAGLAALGKVISQLSSRQPGSHVSYRDSKLTRLLQDSLGGNAITYMIACVTPAEFHLSETLNTIQYAQRARAIQSKPRIQHVADEGDKQALIDRLKAEVAFLRQQIRNSEGSERREAASTERNERKNEREIQLQNQLLDAQESYNALSQRHTKLISQLANESTTNGEADGHPDDLGKSSIERIQRSKSFAESVEQVVVEYEKTIQALESSLSETRSSLATTESTLLERESKCTYVETVNSQLQSRLQKLLDREASTETYLHELESKLDGASTGEEKHATIVAELRKELSRARENEAGCEEYISTLEDRLAESDQDMELMQREMIRLEHVIQRQRGLGALDNLLHDLDTRHQQQNGDDQPRTNGTDVPHIPVPVKTSHHKHTPSLDVLNEAAETAIPESDEGLTEPILEEEEEESVEEFEEATEEPGEDLKVLENVTSQLQARRAEAVCEEPVASPAQSKFVVDKLETVTQELFELRLSHENTLSDYEMLEAKYEQALKALAEIQQDKMDEARHPAPLAQNEPSRPVSFLEDTTAPTLKSGAQHSFSQSLSSELSSAGESPALRELSEEPRDGGVCTPATPIVPSVLSPADAEEAEKMRHVLAEHQADADRMTQKYAELQTEHEEILALVEKLKAEAEAQRHKPSPPSTPGFKMIRRMTSQNLLSGVDRAHRSLTALRTIATEELSSKPDVYQHFEANLDATMHELSSRMERLQSLEAENQSVKKEMEMKATIISGLTRERSSLSGASSVDMALVTQLRDQVVNQENQIQELREAHEAREKQLLAEIENLNALLKSQEVAAKALDAGAEEQDKKIDALEGELSEWKGKHQSALQSLQASEQQLATTLAELESSLVAVEAMRSERSRSVDESPDKEAAAQASEAERAQQQELVDSLKKDIEQHKTTISTHVDTITTLEKSHADLQEQMLAQSSATDINSAPVDMTRIADLEREIATHRSALDSHKGDLESLQESHKRELAELEERTKSAVQAEQDSRLADKDAEHDKAMAALQKDIADSRDELVHLLKAVSSLLNSDVTSATLTDQIQDVLAQKQHFSEKYAELMDTNEDLRKQLEAAGDIEELNKKNATQEAKVNELALLVATLEDTLRQKDEQVKKKEALVEEITVEKQKSVRLVEELEEQITNSFDQHHNRLSVIQQERDQALEDAKARIVILERDIETYRVRIEQLELQVKNGTSDGSHDRSSSLTSNLRKSSSAASLPSPPPAIPLPPLPTIASAANGSGSVSPPSSRHASKEIVNAQIVEDQEARIRTIEKHLYAEKQLTATLEEALGDLESQSTKLKNDCENWKKKAWGLEDELSTLRKERNSARLSLQAVEEERSARKEAEAARAQLEERMNALNKKKKKSTLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ96</accession>
    <name>A0A1Q5UQ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_11401</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ96"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP14643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="434" mass="47881" checksum="4134F09DEC404F08" modified="2017-04-12" version="1">MSNTDFLGRAIDTVKKAIENDNEGEYEKAYQLYYSALELFMLALKWEKNPKSKEMIRAKTGEYMDRAEKLKNHLASAGDKKKPSAVGANGKVAPGSGKGNQEDDNGEDAEAKKLRSALQGAILSDKPNVKWEDVAGLESAKEALKEAVILPIKFPHLFTGKRQPWKGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESERLVKQLFNMARENKPAIIFIDEVDALCGPRGEGESEASRRIKTELLVQMDGVGKDSKGVLILGATNIPWQLDAAIRRRFQRRVHISLPDFNARMKMFMLAVGSTPCHMTQADYRTLAELSEGYSGSDISIAVQDALMQPIRKIQTATHYKKVTVEGVEKLTPCSPGDAGAVEMTWLSIEAEQLLEPPLMLKDFIKAVKNSRPTVSQEDLTRNSEWTKEFGSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR08</accession>
    <name>A0A1Q5UR08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Global transcription regulator sge1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR08"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="487" mass="52739" checksum="137EEA686B88C665" modified="2017-04-12" version="1">MVNGTAAVLEPTFTGYVATTQDALILFEACLTGVLHHVPRRPHDRERSHLVRSGSVFIYEENSSGIKRWTDGVTWSPSRILGNFLVYRELEKPFPPGEKKRAMKKANRRPAPATRPGEPYPRHDSNGSGYSPTSPSGPFADNRAPHQSEVERALVGSLVDSYGFKDSGLVKKTMSVTVMGVTHHLVSYYSVEDVMRGVLNPPSMVESLRYIRPRVDLTQKQSFRAPIDDLETSAMENPHDPSHAALYGYRPQQMMAPPGAYGMPNPSADFYMHAGPYAATHAPQQPGPLASYSMAGSMPGQAAPNPYLPSPAAAAATNAAIPKVEEYHAFRTGPYGGSMDSVSHSALSSSIPGMNSAMSSSFSDRNRSASEHSPSAYRNSSISSRSVATDATSPMDPSTPGTYSRSSFSLSSQLDASNHNTPIETRGIGSLDPNVPRRDSNPVHPSYYAPDRSQYYVNTATPVNHPHYATGQPLSTWTTTAPAQPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR58</accession>
    <name>A0A1Q5UR58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15098" checksum="7BBE51D23B81A38B" modified="2017-04-12" version="1">MSDRSSNGGPHHGTSNIQRDPSGNTAALHSSNNAKNTDSTTDSQSRDRTDVSASTPYMPQSGKLAEKVNHPPHEPNQRVDGDDNGDPEKHRREDVAGSSRWIPQAGKPTVQLTQYACSRADRLLGVPLTASTPDGPENTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMU8</accession>
    <name>A0A1Q5SMU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter ght2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMU8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMU8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="588" mass="65567" checksum="F562247A7A8EE105" modified="2017-04-12" version="1">MKNPFTNNNNSQPQSQSQSQPQSESTPPFPPSSTASDNEKKRRSSSFDESRVPWVTWRSLTLGAFVSIGGIIFGYDTGQISGFLEMMNYKQRYGQFRNGEWAFSNVRSGLIVSMLSIGTMIGALLAGPLADRIGRKWSIFAWCVILHVGLIIQISSPSGKWYQMMMGRFVTGFGVGACSLLVPMYQGEIAPRHIRGAMVCSYQLFVTLGIFIAYCINYGTEHISNTASWRIPLGITFLWGLILGFGILLFPESPRFDYRMGKIDIAKKTMSKLYGVSENHRVIVHEILEIQEQLDAEKGARGGWHGWIEMFQAPRMPYRIALGVVLQALQQLTGANYFFYYGTVIFNGAGISNTYVTQMILGGVNFGTTFGGLYVIEHFGRRKSLIAGGIWMFICFMIFASVGHFSLDVANPPATPAAGKAMVVFACLFITGFAMTWGPMVWAIVAELYPSRYRARAMALATASNWLWNFLIGFFTPFITGDIDFAYGYVFAGCLFVAVLVVYFFVLEGKDKTLEEMDMMYVMRVKPWESSKWTAPAPEEQLTTAQLMDQRVAEGFDREEEEAAGRKNAEMPGHIHAEDTTEAGPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT5</accession>
    <name>A0A1Q5SNT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="102"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO89535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="52263" checksum="9B32F8D0F944C775" modified="2017-04-12" version="1">MSAFSVRDAPFGQLCRLVFGPKVFLYPDEKEGFQYQAPEETPVETPTPQANSSSGDTDADVEKAEPESSPGQSKPGYQTVGWYSETDPENPQTWSLAKKIVTFFQICLLTFSVYCGSAIITPAQPTFVEVFGVSTQKSSLALSMYVLGYGVGPLFFSPLSEIPAVGRNVPYFVSFTLFIVITAVTSRVSNFAGLIVLRFIQGLLGGPVLATGGASAGDILSFPKLPYGLAFWGCATLAGPALGPLLSGFSVPLSSWRWSMYELLILCGFTWILLFFFLPETNADFILLNRAKRLRKLTGNENLRSDSEIKQGSIHFLSLLGVYLTTPFLVTLKDPSVAFINVYTGLIYGIFYSYFESFPIVYTQIHGFSLGIMGTIFLCVVVACFFGAGTYLALVKFHYEPYVYQHGIGSPEHRLLPAVFAALIAPCGILIFAWTSREWINWVVPTIGIVLYMSCVFVVGELTRREDFRVLRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNV3</accession>
    <name>A0A1Q5SNV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNV3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="55" mass="6017" checksum="8C4D59110E8A8ECF" modified="2017-04-12" version="1">MTNSPFGDNAYQPQMVDPRVEDLQYAPTPGSSAANSQHFTPQTLPPIVPHQPQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRI2</accession>
    <name>A0A1Q5SRI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRI2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9429" checksum="E834B188085FCEBE" modified="2017-04-12" version="1">MCGSDDDSNVLYGFTAVDSSASDLLKAACRPSSPHSIRVSETPIPSTPLAQRINQYAQAHLAAPTYNHSLRVYHYGMANKQYRCPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSD0</accession>
    <name>A0A1Q5SSD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSD0"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11059" checksum="667992D9318BA07C" modified="2017-04-12" version="1">MLRQTIIRPAVAANRALLTRSFSVAAPRMGEGDTGAPRSGGSAASDSFTKREAAQEALYIREKELEKLAQLRKKINDQRAHLDELEGHINKLTKDQSGGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSF4</accession>
    <name>A0A1Q5SSF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1327"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1452" mass="160315" checksum="9BAAD97718670A6F" modified="2017-04-12" version="1">MTSRQYNANEDRNLLGNTKSYFSHIVRPSRSSSREGSSERDDSSNNAPTPGADQRARAEPSEKGSGVWSKDWFPYTFTHWFLGVTTLVALALCLVCFLLWWTSSTNYGLGPDDGSSSLLFGWRYSPTLIAVIYVQMTTVLLQDVKRTEPYARLARPGGADASCSILKAPGAWWTALYDGFAKKKNGGRSAILICASLVNIIGFLAISTLSSAFLFSEEVVVPKSMDFFSLAPAAGSTLPLDADRTTHFRTIANLLQNVSTSPWITDHYTILPFWPAGLDTAPVTSLPTSSTQKWTAETMMFKSDLTCTPMKLEKKASGPIIYDEGYSPTDSTSTIWSSPDGCRYGMSASTHFWSTGGGSWSDASDFYYAESSLGMGGGRVSSSNHTSECNGRQIIIITESSEIQNAAFSAQVCDTTYYMANITASVALTGDVPDISFDANEFEQKKVVIPESVLNTTAMRNMTLNENWPTYMISILWSGTATLGGPSVLLGALYDYNMTTMARDPNWVISAATANQRYFGEVLQAALTHQGASQRVPMQGTLHDIETRVVVQTGPAVALGVLFAVSFFLLLAVWWCSQSRRRPLHLKEDPASTLGVAALIAHNGRVNSGFQNFRQPSAKDLNERLNGQRFYTDSHGLSRLNPSDTLNHDVDQSKNGTPGLLRLPALIALIVVLIAVFVGVCVLWHFAVSVGLYEKAFVYHVNISFLSNSISSVAPVSMIPTLIATIIGLWWSAIDDTFRRLQPFLAMADGDPPISRGAGLSYQSSFWLWACFKAAMNRHWLLSLLTLGSTLSPVCELVTRFFWLQRLMLTCHPVTTTMSALFDRGPGVVTQPITLDRSLEIRQIPFVFETKQAVYPDTNNDYAAYILADLYKNISTHWMYTATIQLALNGSEPAWSKEGWSFVPVDTHTVSNVELPNDLDESDRAASGAPSNVTFTTPAMRARIECSTYPVEAFMNVSHWLTPTDLSNSTTWNRSTIPHDLQEGFELGTSWIYQKSPSVILPLSGNETIKTCDGCTTVFVNPSSITCCGNSSSSAWDPSVAVGYWSPNANLSQWSTKYWHQNFTLKWIYGNAVTGINANPTTENITYNIPLLFPSPPSMTLMNCRPLVESANADVTVNPANGEIQTYNITGHPTELVEAFADNFLPHNGTDLTRERGMAFYNVTVSLGRLFMASMLTAADTLHIGGAEHVGGYHQEDLNDNTYNIRDELNGLNMDFMSYAMYSMANKDPKALLNPDRYLTLAQKTFTTFFQHFVSNNISMETGGWGYQTINASLPDTLGPIVEVVHNWLPGTIATTYQDDMRPISHANRTVAAHVSQRVELLQMNALAVWLSVGIMGWLILTTFIVAILQRRYFGRLVRNVECLGDVLVLIAGSANLLDVVQEIQAGRLSPEDYEHLRTRLGWFMDEDGRLRWGVEMEEAFRNGPGVQWVAAPFFSKKGTNTWSLSDEDRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ST21</accession>
    <name>A0A1Q5ST21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ST21"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ST21"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="136" mass="15594" checksum="9CEB5DBAEB71A8F1" modified="2017-04-12" version="1">MATLALAYLFPDRILSCNLDQQWQGFFQSKNSHAIRSIQDELQCCGLKSLHDRAWPFKDQSHGDNAWWRFMQMALAHLSGQRGSWLSTQSCSRPPGYRQISHLEVPSEESDENNEEAGRTFLPDANIPTQNQWDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5STG4</accession>
    <name>A0A1Q5STG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000751">
        <property type="protein sequence ID" value="OKO91297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5STG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="85"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="285" mass="32602" checksum="042C8CDCE782C06C" modified="2017-04-12" version="1">MDTIITNLPPNVGTILIENISIIQIISMLSIGAYNALETGIAVFDLFKHYRGLYFWSMQVASWGILVHTILAMIRFLSQSSNLAIGQSVFARPAAIYDRIQVTGFCIQEFVLSGVYIHQALEQRSIKRDLHRQDDRKIIRHLLWINILVVLMNILLLVAEYKLHXIEVSLKTVVYSIKLKLEFTVLNRLRKLGFXSPPPLAHQIPEYARQESDVNLVGQSRLYSRQESNSELVHTECRIKVLPRVSQRPSIYANHKAKCDAQSDDTRVRALINMNEALDHNSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUF7</accession>
    <name>A0A1Q5SUF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUF7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13268" checksum="88B5A35B545ABCFB" modified="2017-04-12" version="1">MSAQSTPHGAVLKVISLGKLMSSPAAVAAELLAACTDMEFFYLDCTDWKDGSLSASQVQRLFQITKTLYDLPQKEKSAWAADHHHSEETIVGYKEAGIDPGPVEGRKDGFEGFMVREYLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWC9</accession>
    <name>A0A1Q5SWC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWC9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWC9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="54"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="307" mass="32891" checksum="E2B9ACDC7EF7048D" modified="2017-04-12" version="1">MISAGFPVKNGTLYNDGAPVPEWSLSSHISAMDSLGVNYSTLSITAPGVSFIKDAKKAKSLARSINLLLQEFTQTYPTRLGALCLLPLPYVNEAVEELRFCIDSLKFVGVGLYTNANGTYLGDPTLDPIFSALSTHNASVFVHPASPSCRSVALSHPIPMTEYPFDTVRAMENLLLTGQRAKYPDLKMIFAHGGGAMPYLASRIAGVATLSYAGGIPFAETMAQLAGYYFDLASATSAIQLTALKSFIGAGKLVTGIDYPYVPLAQAVPGLTGIQKNGNFTDEEMTLIKYDNALEIFPRISSALKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXG1</accession>
    <name>A0A1Q5SXG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXG1"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="548" mass="60959" checksum="1FE0165D246B0231" modified="2017-04-12" version="1">MSDVWERRSSTGDDEWDKPDSHSLQKGDADGWTTPLQAKGDDDGWGTPPEGDSNRENMDPHSTEFGDEPSPTPGEGGDFACRKCGETGHFARQCPNAEAQKCFNCDEPGHSKADCPNPPKPRACFNCGGEGHSKAECPNPAKPRACFNCGEEGHSKAECPNPRVFKGACRICSQEGHPASACPEKPADICKNCRQEGHLAKDCKENRKFDLGHIADRLPEEAWAMMKKASDEKDMDDFREAIQIYTKAVPEATYVDIEKKMRSEEFKTHLIALTKDREDIISLIDLQGQLDREYVVGYFFSDKPQRANHEERWPSDAEDNLERLANAGLPYDRQVIKCRNCGELGHGSRACKEDRVEIEKTEVKCNNCGTVGHRVRDCTEKRQSKYGCRNCGAEGHDARDCPEPRSAGDVECRRCNEVGHFAKDCPNQTERPPRTCRNCGSEDHIARECDQPPNPDLMVCRNCEKTGHAARGCPEPKDWSKVKCNRCGEMGHTVKRCPQPEETEDTGFGRADAEEASWGQADAGGQGDDVETVRQGIEESAIAENSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYX0</accession>
    <name>A0A1Q5SYX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYX0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="520" mass="57940" checksum="68A7A60A0332D6A8" modified="2017-04-12" version="1">MRSFLGRGKTLQAGLTVCCLIAFVLFGYDQGVFGGILENEDWLKQFNHPSDSETGIIVSCYNLGCFAGCILNYMIGERLGRRRTIWLAMAFVLVGAILQTTAFTVPHLIVGRLVTGCGTGIKTSTVPMYQAELCDQHKRGRLVSAEVLFVGVGIVVAYWFDFGMSFVGGSIAWRLPIAVQMIFAIVVVALVLGLPESPRWLYKHGKSAEALDVLCRVYDREPTDEYIIAERDAILGAIELESRENTSRGLLSIFRNDRVKTRQRVILAWLVQFMNQAGGINLVVYYAPSVLVQNVGLSPKLAQILGGCINMMFMFGSIIPSFYLDRMGRRKTMMAGCAGLSLCMLMISALLSRGDMPNGHTYSSGAVAFFFLYMLIFGMSVNCVPWVYVPEILPLDARTRGTAVGISSNWLWNFTVVMITPVIIRRLHWKAYLIFMVTNALFVPAFYFFFPETSNLRLEDIDYVFSRSGNPVKNAQQVAAELKQHGHVVDLDGNGNEMSSSHSHSEEKAIREVRKEDVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYY2</accession>
    <name>A0A1Q5SYY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYY2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYY2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9664" checksum="227F1D3B61E2D406" modified="2017-04-12" version="1">MGSNDSTENGSKFILTANALNKALPDMSMATRAVHADDFVSPHRAIAPAMHVAVNFRYARDPKDLVPEENKDVRVSTRLTELCPDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZF5</accession>
    <name>A0A1Q5SZF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotically up-regulated gene 80 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZF5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZF5"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67467" checksum="5DACDF9C894C7E00" modified="2017-04-12" version="1">MSPPTLDSRSSTTLGPITPTVDLTSHTYPAIKPAFETTGSCWTAPFRDGLPTPPSDMTGVAYNAIPPAAYGGKGHAMPSHLHNHSRSNYGSISSSMVASMKSNHSATQSAPAPVKEAPVTEPVSQKKSSGTTATPVLRIPSSINNSNGTLAEFAAQMTCLFWFEKTPKLQAIEDRRNPALSLVSEAFPTVGFQKWVASILATTQVSQNVILLALLFIYRLKKFNSGVKGKKGSEFRLMTVALMLGNKYLDDNTYTNKTWAEVSGIAVQEIHIMEVEFLSNIRYDLFSSKEKWAEWHTKLGLFSDYFNQASKLPAEGETPLMRVSPPRLQAHSPLSKLPSPPMDAYRPQSQPQQSNWFGTLSGLPYPGTAQLGEVAVGGPRKRSRDDDDELHPVKRAMTAAHTTPSLTIPSSNMTSVVPPLPPVLTPTSAPVAQTSMAGHVARLPPPNLPSSNTMPQSLPSTAVSQLPVPALMPTAYQRNSNWAMQMPSSAIPSTMASGIYNTTALPELGRHQSPYGVSSATVSPAVSAYSVHTPQKHLSPSYFLANRNSPYRPVRSVNTLLIPPPSTSMQHQRSVPFDHMHYQPLGKSSTDRKTGLLPYIHPESWNQIHFQPLFPPTQFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZJ2</accession>
    <name>A0A1Q5SZJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="576" mass="64684" checksum="50EF28A2D65D95E8" modified="2017-04-12" version="1">MMRGTQDSSDVSSSIQSLSIRAPGPEATARAEMKERWEDALKHCEAELSKEDFQLIVKFKSPEELIKAVDNMITETQNASVPRILRQFKPHLSQIQNFVLGILASVTLPVVETVCIWGLISLVLQLAQRSQEVLETVTGMWVEIGNSLQIFDVYKDLIVEDMSLGLALVETHEELLKFAVATIKTLRHVRSGRSDISPLVRDCQNSFGKTSHFISHRIHIIKEKAQAKAITKGQEQTHQFEILNYLASQSGAQLGTMEEAELAKLPSYYIPFSRNPKFYGRNDILGKMTAEFSKDRAKGQPLSVALWATAGVGKTQIALEYAARQRQRGIKAIFWIDAEKESERIKAFNDIAHLLELPGASTPRDSEQNRLIVQRWLQETKTPWLFIIDNLEDQESIQAHEIMESICPTYGCGEILVTCRSELVAASAAVSSIEVPAFTNEEGAELMLKLLDRGTYSDADRSSSVELADLLGGHALTLDVMARNIVARKKQLPEFVRVYKEKPRSLHMKPRKKIVNRYYKREDDPESLWAIPFSQLRSDEAEVLGILSMCGPNKFPSSVLVPETSAPEAFNIDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZN1</accession>
    <name>A0A1Q5SZN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_12348</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZN1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZN1"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="192"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO93285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="41348" checksum="81ACB3335F145F50" modified="2017-04-12" version="1">MSTATTVSKTNIGVYTNPKHDLWIAEAEPKVEDVASGKTLKPGEVTIEVRSTGICGSDVHFWHAGCIGPMIVTDDHILGHESAGQIIAVAPDVTSLKPGDRVAIEPNVICNACEPCLTGRYNGCEKVAFLSTPPVDGLLRRYVNHPAIWCHKIGDMSYEDGALLEPLSVTLAAVERSGLRLGDPTLITGAGPIGLISLLSARAAGACPIVITDIDEGRLAFAKSLVPEVRTYKVQIGLSAEESAEGIINALNDGKGSGPDALRPKLCLECTGVESSVNSAIWSMKFGGKVFVIGVGKNEMTIPFMRLSTQEIDLQYQYRYCNTWPRAIRLVQNGVIDLHRLVTHRFALEDALKAFETAANPKTGAIKVQIMSSEEDVKAATAGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0H8</accession>
    <name>A0A1Q5T0H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0H8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0H8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="52"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="773"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="883"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO93778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115821" checksum="FD50C92BC73E4CB2" modified="2017-04-12" version="1">MSAYASPTHAQQGHAAAAVPRQFPAFNPVAVVTAPAGTFLPGTKVQVGSHRVVVEKYLSEGGFAHVYVVRLPQPVNGTETAVLKRVAVPDKSALASMRTEVETMKKLKGHRHIVRYIDSHASQLQGGGYEVFLLMEYCGGGGLIDFMNTRLQNRLTEPEIVKIFSDVAEGVACMHYLKPPLLHRDLKVENVLISRSQGSTIYKLCDFGSSAPPRPAATSAAEGRLIEDDVQRHTTMQYRSPEMIDVYRKQPIDEKSDIWALGVFLYKLCYYTTPFEEVGQMAILNASYKFPAYPQFSDRLKMLIGKISDRGGLVRAKNIMTDWNSGTAIMLKENPQKRPNIYEVVKEVCDMQKKEVPIRDIYSNRSVSEARRNQELPPTPTEAPAVGATFSPPMQETEIIPEIAPMRRGRPGKPQSSAHSSAKPSPSPYRGGSKTSSHDPFAALDGNAKKSADELSNRFPTLDQFDILHEKGDKFEFEPTVKEAKSEDEDLSQRLTNALADDAFARRASPERQAPSADRRSQISPVRPQKPQEVSNRQQAPLYQPTPKRPGMVSTGTMTSPSQTPRLQEPKISSRPIYRFPAPENERRPSSQPWTEDEQKASGYKAPSPPSANLRPEASPRLSSERLSTHSNSARPSMETLRRPSGLEATDPVGRSKSAIAKARPVSVQASSRYDLPRDTETSRSSLDLPHMQYEGGAPLRPVRTEIDREYERANISSDVDYLRAKEEEESNRKREKRSSSGAKHAKRGSLSSLSLSGSKTLFAGRFGEAFRRFESTNQDKPSTPTAEEYPQHHKALIGDSEALDSPPNEGLSSYEDDVLEDVDRDDISPEMRRELERRRLSQEEKRVANAAAEYRRRVAEGDGSGQHRSRAILNRVQNFIGESNKPQVAPKTATGYGKYTDAGALQAKPGNDNQAPPSSALPVSRTPGPIYGAREGTMAPRDRREGASAPAGLTQSATATANSAGYSSVRPPSRPTAPPKPKNLRVGGQDSSRPSTSQDRSPSVQATPTSPGGEDWEANFSRRFPSLSGLEMETEIEVPKYPKLRTREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0I2</accession>
    <name>A0A1Q5T0I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase andH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0I2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0I2"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36556" checksum="DF5989405540143C" modified="2017-04-12" version="1">MIALSTVQSSNAASSKELPSGLVGVFVGATSGIGKATLLQLAKYARQPRFYFVGRSQSAADEILPQLNQINADGKYVFIKADPSLLSVVDEVCQSIQQNETKIDILFQSQGTLDISTETSEHLPLIMALSYYSRMRFIANLLPLLQKSPFGRAMIVMAGTKEGPINANDIAGKRILPWKARGHLCSMITLTLEHFAKLAPGVSFVHNYPGFVATPLAKSMKGVTGGIMRSVFYFTGLFSTKNYISLEETGERHCFLATSSRFESKERYGGSSGREVAVGSDGVVGSGVYIVDEVCESGGKDVQKLLNGVRQEGTHEKIWEHLQSEFLRVTGKSTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0L0</accession>
    <name>A0A1Q5T0L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T0L0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="9">
        <location>
            <begin position="509"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="7">
        <location>
            <begin position="1304"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="932"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="942"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="970"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1419" mass="156338" checksum="41D645E9A41CF3E3" modified="2017-04-12" version="1">MSDVDAVSLPAALDVGPNNTLAAVKTDGDADTRPSGRPLSPNRKDKAASPIPAPTAAVASASASASAPVAASNSTAFAAPASPRREIAGSHPVDEEDDEQGPPSPKADSEAETIIQSGRESLSPEKKRKHIRHDPNRQGVDGVDGTQRKKPRIDHDREKRAPRSRSPRDRAGSPPSVVKVEKVDEVPSVSEDVMEESGSSNDGPERPRNYRKRSFSDSVDEKRERRRDSTAHAARDLKLLNHARLSRPSASTRSVSPGRPSHHRSASGSHLPGKKKAPTPLLTGFQRQTSEDRQSTSSSASGSPLPSAHLRKLGSGVGASASPAKHMGPKKLRDKSGRTPLARACADRKYDQVVLRYGERPEDLNVPDNAGNTPLQVASLNGEEQIVKFLLDAGCEINTKNIDKDTPLIDAVENGNVEVVKLLLEAGANPRTVNASGDEPYELVPTDLKDDEYDEIRKMLEDAKANSRPGRRSEEQQAGPDKPPRSRRASVASPSRSPPPMASTTGRRKTGRSEATRNDLLWTQPTSENLREFAAKGDEQGVVSILNILQKADNASLIAAAKGGHFDVLSLMYAIGDADADPNPLRGSGHKPGYNTPMLAAIGRGNMDNIQLILGQPGFDPTRRLFEDKTYYELSRSRQGENWEEEYDILKKAYEKYLGLGKGRKDLSSPRRARGKDKEEKRSSRRESSSPVTRTKKLNDSSPNANRQRFPKDQDALKEKRREEKKAAAAAEAASGRSKANSRDARESRDAHDQALASSDHDSGRPEPKKPKAAPSARRGSESSGVARNDEVRKRRLIAGRRPQDGDRRPSLISSDSLSGREEAPRSHDTAPDSTSSLKRIRTDTSPERSRSRGRDSDRLSPEARKKKRRVLAEEKASNLPNGSSRKAEDTNGDKPQHRRPKEEASQGTDPAPRKSTEASQKSELSSHKPDSSSLPSSQKSVDSEPTKKNGDVKTEAPEPTTNSIPEVSTDAKRAEIEAEKRRQAEVKKAEEERLAEEKRREEEEAERARLAKEEAERAAQAAREKEKADEEERKRKEMEQRRAKQAEDERLKRLEQERARVIKMRREQEAQEQRRRDALPGRLRASANFVGSNDPRARSHAWLKNFMPLVTVVTRQLDPGCAGDVADEKWIPNYLVAPLLATNDLQLSQYASWEKRKATATQRMNLWRCTRRMLVYTDDPKYYNASFGDVMQLDCETRPKYFDMEHVFWIRLSDFTDLVPHIPHLNGLELEFVSMHLDPEPSTGTSHQTNGSAPSTLAVGTNGIGALNGHGSDGEEIQNPPVAADEVEVSADAGSGQMSVLDALKGVLRISLIHDGLARGLREAAKALDRREAHMCVLNEGCEEEAYKKLVVALCSEHKIPLIKVPDGKMLGEWVGLCTLDREGNARKVVNCSCVVVKDWGEDSQERSVLLNYFQTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0T6</accession>
    <name>A0A1Q5T0T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scyllo-inositol 2-dehydrogenase (NAD(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0T6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0T6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="191"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="345" mass="38344" checksum="7A8B1920924CA241" modified="2017-04-12" version="1">MSSPQRLGLGIIGAGVRTLPQEHCATKFNVPHKTTIPQEVIDNPNVDTVFILTSDESHAPLAIASLKAGKNVFIEKPVSLSLPSIQSIIDAEKNAPGGARVFVGYMRRYAPSFLQAFKREIATIPKILYARVRDFSGPNAQFVNQSGTFQVKNSDYPAGAAEERDARLEALYAEAFPNQEITDEMRKFCRFLGSLGSHDISLMREVLGFPEKVVGVSANDPFYSAIMTFRNQDGSSYSTTYESGIDGVPVFDAHIAVYGANKRVTIKYDSPYVKGLPIHVEVEEPNEHGEIQRRTMLSSYEDAYTAELQEMYEAFMHGKAIKSTVQDAQKDLEIYDMMYKSWSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Y6</accession>
    <name>A0A1Q5T2Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Something about silencing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Y6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Y6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="566"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="640" mass="71965" checksum="2CA3BEC6EED6CBD4" modified="2017-04-12" version="1">MGKKRKAGGRPAQKDDAPMRTKYSIEERFEDSEDEFQANRDQILLEEAPEAKRRRRVAEDEEILQPSDEEILGYESVDEDEDDLESEDDYDEDDDDMGLSKKARGAESEEEEEGIAAWGSSRKDLYNADQIETEADALEEEQEAKRLQQKQLQAMDEADFGFDESEWAESGNDGQDDAEDTGVVTEVLPQLEITEDMDDDEKRRILSSRYPEFEPLAKEFASLQPIYKDLQKAASKATSTPDEDSDEPQPAPVAVVKLRALSTYLGTISLYFMLLASSPEGSDADVPLSPAQLRQHPVMGSLVKFRKLWETVKDLEISEVVEVIQKPVKAASSEPTKAEKQPKKTKEVKEVPQKKKLSRAERAAETARAEAEARRAERLRQTEAGLADLDDLVTAPGQKRNTKKSKKSSKEDDESDFGDENALTAREAEEKAKQKRSLRFYTSQLAQKANKRQSAGQNAGGDADIPYRERLKDRQARLNAEAEKRGRQRPDIGEELGGDSDEEDHRVRKELRSGGNQSGTDEDEYYDMVAARSKQRKDDKKARADAYAAAAREGGQVHIQEEVGADGKRAITYQIEKNKGLTPKRSKDSRNPRVKKRKKYEEKKKKLGSIRQVYKGGEARGGYGGELTGIKKNLVKSVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N8</accession>
    <name>A0A1Q5T5N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N8"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="52711" checksum="E6331534D4303C17" modified="2017-04-12" version="1">MSAAKSRWADNDPETEAIIAQRKREKEEKRRTKAEKQRQLEEASKAPAPIEPADADQGVNGEQGPPKKRRRLSNDPDASSAAGEVSTSAELKKQSSLLRFPVGEWGPCRHVDNFERLNHIEEGSYGWVSRARDITTGEIVALKKLKIENSPDGFPVTGLREIQTLLEARHQNVVYLREVVMGNKMDDVFLVMDFLEHDLKTLLDDMREPFLPSEIKTLLLQVVGGLEFLHSQWIMHRDLKTSNLLMNNRGEIKIADFGMARYYGDPPPKLTQLVVTLWYRAPELLLGADKYGTEIDMWSIGCIFGELLTKEPLLQGKNEVDQVSKIFALTGPPNQQIWPGFRSLPNAKSLRLPQTSASPAGNPPLLPRSRFPYLTNAGLNLLSTLLALNPASRPTAQQCLAHPYFREDPRPKPKEMFPTFPSKAGMEKRRRHHTPEAPKRGQDAPELDFAGVFGGAAGGDTGEAGAGFSLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T619</accession>
    <name>A0A1Q5T619_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T619"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T619"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="58454" checksum="34E17AA51AEB3EBC" modified="2017-04-12" version="1">MLADELSIRVAYDENLIDWVVPTLGRRSEEETRRARLPLLEDIKCELSVFKGWIFSVFGLLSKPVSEQQAPDTLNQERIQNLRNSIESLQHELEEVQLRNNIAGDTPEAALSRLSGALARTTTVDVTRLDLPTIAEDDQVTEAELDLGMNQVLTNENRISQSPGEMSSDYFSEMATLGRTSAPSPSSVSRSSPSNAQLVDSPSSMGRDRHSSRANTLFSRPSSPETSPPTSPRVRASLIHQSSDIITMQLELLGNRNRNAQNQTSNRNSPLPRIGRGTTGLRPPSNGTDRRSIADFLQALILSQAQQGASQSPLPTEHDTLSNTNAVGGSTASQEIPAVGPTSQRPTQQSSASNQPSSGLSREAPASNIPNILPDGVEEPTEDEIDGQPSAVVRRTQNAETRPNMGDQLPPIGSRIPRQAFTSNISGAHRVTLLSSHPVDSLASHLAALISTIILSPIESLCLRSLAHSYLALHPSATTGASDLYPVGLWFGGNTWPEVLAYSGKIILMRGMQAALRAGVWGFLVGSTMRIGRKFCGWGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6L8</accession>
    <name>A0A1Q5T6L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complex I intermediate-associated protein 84, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6L8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6L8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="741" mass="83579" checksum="3E5A85D69A9EBD98" modified="2017-04-12" version="1">MDPRAASGEGMPTTLSSEKGLKPMTDLKRSLEDKSRAPPNNTLVKAFKLFFETRVDSPGVINLFQARLLSMTWKHLKAQQEELDDDDWNNVFSVDSLERILYVFSEAQCLPEARETVLKIARYAYLELCADHGFGPNSISRPALLVYINLLAMNGNPEDARQVIINFGGQLRGAKPSPWLTVLKGFALKDDRRQLRKITQELEKYGVKFDQASHEELVDILIAQDLFKAAQTAYECPMAGNAEPSLATKKAVINYAILQSDTAWAEPIYQSICEGASPNPETVGVALLWEAAQGASASSLGEKVKSWTATNPRIREALTIADINNLLRYTHANENPQLATAFLNLAEQWGLAPDEQTHLLQLESAIQAGDVEASLHILENQVDPTSLPNANLSLSNQLITMLCSSEKKDELFQQISSLLDPLFQDGVHLEPTTVAALTRMLLYRHDNEAVSELLRPRLATYDSQGKTVIRTAVTDFILDLNEKDADVWEVYELFKLAFPETGVSVRTEIMCTFFERKRSDLAVLVFGHMRQAEDLSRRPKPDTYARCFQGLARTADVTNLELVHNMLKLDLEVELTTRILNGLMLAYAACDMPEKSMNIFRQILQSDEGPSTKTIALFFKVCQKHHNGVQEAIKMMSKVKKLEIEVDRRLYSSYMEALAAQCEFDRATEAINNMRAEIGVPPTSTTIGLFYNAIPYQYWKDQVEEWARKTYPELWEHLEKTERSEHEEGQKFDGISNEVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y4</accession>
    <name>A0A1Q5T6Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y4"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004354">
        <property type="term" value="F:glutamate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000001">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.285.10:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000002">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000030">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.10">
        <property type="entry name" value="Glutamate Dehydrogenase, chain A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050724">
        <property type="entry name" value="Glu_Leu_Phe_Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006929">
        <property type="entry name" value="PRK09414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43571:SF1">
        <property type="entry name" value="NADP-SPECIFIC GLUTAMATE DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="462" mass="49704" checksum="63CBFCF8B3A74394" modified="2017-04-12" version="1">MTAQNLPSEPEFEQAYKELASTLENSTLFQKKPEYRKALQVVSVPERVIQFRVVWEDDKGQVQINRGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQIFKNALTGLNMGGGKGGSDFDPKGKSDNEIRRFCVAFMTELCKHIGADTDVPAGDIGVTGREIGFMFGQYKKIRNQWEGVLTGKGGSWGGSLIRPEATGYGVVYYTEHMIKYASGGKDSFAGKRVAISGSGNVAQYAALKVIELGGSVISLSDSQGALVLNGEEGSFTPEEINAIAAIKVERKQISELASTEAFASKFKYIPGARPWTNITGRIDVALPSATQNEVSGDEAKALIEAGCKFIAEGSNMGSTQDAIDVFEAHREANAGAAAIWYAPGKAANAGGVAVSGLEMAQNSSRVSWTSEEVDNRLKGIMEDCFKNGLSTAQEYVTPKEGTLPSLVAGSNIAGFTKVAEAMKDHGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T818</accession>
    <name>A0A1Q5T818_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIID subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T818"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T818"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="210"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="585"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="696"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="746"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="775"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO96374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="850" mass="92709" checksum="D42DECE8E5CEA782" modified="2017-04-12" version="1">MPSRKKGRKPPKGDEDYHPSEAARKSAAAAAKRSPGNQPSGPSTETPRTPTARKAPEAAGPSSVQRTTPAKRPARARKSVPAEEATSAEVVPETPGPSLVLRFPVSLGKSGHPRKTTTTPKGGNVEPSDKTEGRRESDPNALPAPVEEPAAPAQVPHTLETLLEQASRPDAVIDYLAKKGYSRTEAMLRMESANQEIDGRPLPPLGEDARPKFRKGFDLLKAWVEENLDLYKPELRRVLWPLFVYSFLNMVTAFYPQDAKQFFDANKNMFLPEHTDDVRKLEPISLPEHVQANDTAKLYRTNKYRIVLSNPAYTNLLQFLESKEKEGGSVMNAILSSYCTIKTMDRAADDRFSFAAMLGQIGAGQSFPSEDEGIPGHHAGSAYTGDNPAMAGTLPRLRLGKLPMEQNLEEDVRAELAAEDARDPPGPGRNTLVQEFEQMIKKEEDEEAPTRADIPFPESTARDVAIECMKVRENRDRFRIQGRTGGVGPAVSVCMFTFHNTFDSINCLDFSDDNKLVAAGFAGSYIRVWSLDGKNIEAAFPDLDDLPPANSRRLIGHSAPVYAVAFPPCATKFENVSSEDSVPTNARLLLSSSGDKTIRLWSLDTWQCLVVYKGHDRPVWDVRWGPFGHYFVSGGSDRTGRLWLTSHIRQQRIFAGHDQDVDCVCFHPNSAYVFTASSDKTVRMWAITTGNAVRMFSGHTGNVTAMECSRDGKILASADDAGSIFLWDLAPGRLLKRMRGHGNGGIWSLSWSVESTVLVSGGADGTVRVWDVSGPQDASQGRVVGEGGAGTKIDGGNAPASATASSKKKKGKDVVVTPDQISAFPTKKSPVYKVKFTNMNLIIAGGAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T835</accession>
    <name>A0A1Q5T835_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Grainyhead-like protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T835"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T835"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="2">
        <location>
            <begin position="101"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="467" mass="53237" checksum="44390D375322631D" modified="2017-04-12" version="1">MFKTGNRQSSLHPILDTIWSGHPGLSNWSTSFEQQMQPGLSSNNFWEQKLVSPFSSGHKNWNERTRSLSQSGPCQSSENLETPWTQTFSLNSTKKCHDENEMLRFHICLGAPTAMVSDQGEKPETYLNKGQIYYIRIVDTAPPPSDSEKTTYRTFVGVSFKEQDQEMSAEAYWRLWAVRRAVSNLDETDHEHRAVEFADEQRPWVELTEEFTNGFSVTWTIDSLTSLNECHIPVRFNFLSTDFTLVKGVKGLSARLCVKTDQVNTTELPYKPEVCFCKIRVFRDHGAERKQSNDVTHVKRRIKKLTEKATTLVPHEALRRRRRGNPVAGKMKKLEAAFSSLTDEYACSTEPDELKAYILPNEPELQKKLVKLRKMLLSGCPESVLSLQGGRDDDPETQTIRLQSGCNSTPKQRATTSEGSLRGVSCHFSSPDHIQNNWLTRTRMSTSLRKSPTPSEFYYLCSHCSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8P9</accession>
    <name>A0A1Q5T8P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">L-type lectin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8P9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8P9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012569920" evidence="8">
        <location>
            <begin position="25"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="312" mass="34131" checksum="7D736507E7FC1EF8" modified="2017-04-12" version="1">MRFPTFSSLLCLAGLVSVPVNGYAGDDPNIKSIPVYSPDRRPPVAARMGLLSRASNRDQLGGETTQQPSPVNKAHSHLQIELEFEIHGNGNLHGDGFALWLTKQRATQGPVFGSTDRFEGLGIFVDTYKNNRPGVSFPYVMAMMGDGSTTYDQAHDGKANELAGCSARGLRNAPVPTKLRLTYFQDKSLTLDLQYKTEDTWTNCFTLNAEDTNIAIPSVAYLGLSAETGELSDNHDIVSLKAENLYALNRNAGTKDFDGSKSRGRGGASRSAQKESGSWSWFLFKIVLFFGACAGGYFGWTIYRTKARASRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9D9</accession>
    <name>A0A1Q5T9D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase ucp12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T9D9"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000016">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="388"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="568"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="810"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO96847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1332" mass="146617" checksum="2C91F610E6C34D64" modified="2017-04-12" version="1">MGPKKKTAGPGGPKPGTKQAKAAAEKAAEKKPVAEEPKKPTVKEVIGGASWTGKLPVNLLSEHCQKQKWEKPEYSMIQTRDGYVSAVTLKKIDPKTKELIVLPPMKLPPTHKELAAQATALEARHFAAAFGLFRVCNMRNLHMMMPPKYKNLWREEFAQIKTAETKEGKGWLYEADPFLAKQERESAAADLEKKRAERAKMQAKEKASGPELGLGSGDAKNKRIWSQAPKVDMGTRIRREIEGLLRQHTVWNGYGVKIPEQEKNSIVEEFSRLGFRRSHVEEAVVECKDREEVLEWLLIYVPEDDLPQWSLPEGYSAGVSLAAGDLAREAKIKRLAAIGYPADLCSQVLDSKSGDELAAAESLQGTLTHGSTFATTSIPDGDAGAWAEEQDTIEAIFGERYVRVSPRVCEIKSEGSEIPENTIFRFQEPSNHYPTAPPVISIQAKGIPAYIRLSAIRQAVQYAEENFSGESMIFNILDWLEVNLPSIMANPGKLRDISSVTSSAAAETREIPVRTSRRQRKGIDWKPNSQQSLAIREAWEAKQNTPAQVEMCRKRKALPAWNTQEDIIYAVDNYQVTIISGETGSGKSTQSVQFVLDEMIRRGLGGAANIICTQPRRISALGLADRVSDERCATVGDEVGYVIRGESKVKQGVTKITFVTTGVLLRRIQSGGDADGNVASSLADVSHVVVDEVHERSLDTDFLLALLRDVLRHRKDLKVILMSATLDANIFMDYFGGSKSVGLVNISGRTFPVEDYYLDDVIRDTGFAPELSESFEDEDDAPQGEASLGKALRSVGMGINYDLIASTVQYIDDQLGDEPGGILIFLPGTLEIDRCLTAVKRIPNTHPLPLHASLLPAEQRRVFQSPPRGKRKVIAATNVAETSITIEDVVAVIDTGRVKETSYDPKDNMVRLQEVWASQAACKQRRGRAGRVRAGICYKLYTRKAESNMAQRPDPEIRRVPLEQLCLSVKSMKGIDDVANFLANTITPPESIAVEGALTFLHRVGALDHDRLTALGRYLSMIPADLRCAKLMIYGSIFGCMEACLTIAAILTVKSPFVSPREKREEADAAKAAFSRPGDGDLLTDLAAYQSWSERARAQGYWQTQSWCGANFLSHQTLRDISSNRAQFVSSLKDAGVLPVDYNESAAALNRNGANKNLLRALIAGAFQPQVAQISFPDKKFASSVTGTVEVDPDARTIKYFNQENGRVFIHPSSILFSAQGYPNAAAYLAYFTKMATSKVFVRDLTPFNAYSLLLFCGSITLDTMGRGLIVDGWLRLRGWARIGVLVSRLRTMLDEALQARIDNPALGSSGGAGDRVIEAVKKLIELNGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9I9</accession>
    <name>A0A1Q5T9I9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9I9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9I9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="109"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="579" mass="64462" checksum="019264BAF0CA3A17" modified="2017-04-12" version="1">MADLHLPPSAAGNASSDSGSTNPRFTPVSNGSEEEYPASKPVNSPVGNLRLQTNFEDGMGVAGSVSDMDEENTYDSAEELEGKDRRRQSRPKFTLEEEREVVKVFDRRLVPFLALLYLLAFLDRSNIGNAKIAGLQDDLRLSSEQYEWLLTAFYITYILFEWMTLMYRLVPPHIYISLCVFGWGLVASCQSLATSFEGLVILRALLGITEAAFGPGVPFYLSLFYRRDELAFRNGLFISAAPLATSFASSLAWFIVKVNSDGPISPWRALFLVEGFPSVIVAVFAWILIPDSPGRARFLTRRQRVVARLRMEHGQPDYQQGTSKRFDWREIAKTAADPKAYMAAFMFFSCNVAFSSMPVFLPTIIKDMGYSALNAQALSAPPYLVAFVVVLVTAWASDRSRSRSPYLIAHALISSIAYFAIAATGYFHEHLSTELHTFIRYICVYPATAGFFSAITLIITWSMDNRVEKEGKGASIAILNIIGQCGPLLGTRLYPESDGPWYIRGMATCSFFMVLVAILAIGLRLLLQRANRRAVNTVYQAVDQAGPAHSGEERDELMGGGRRDDLEHHTGDRRLVYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAR2</accession>
    <name>A0A1Q5TAR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_10123</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAR2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000159">
        <property type="entry name" value="Class V chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF337">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3 10" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="257"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO97329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="42835" checksum="F42F5E52ECA814CE" modified="2017-04-12" version="1">MAFAPTKLFNSDSPPSFTPFEPVDTMRKRFGPDTKVMIAIGGWGDTAGFSDGAKDDTSRKRFAENVAAMLDANNFDGVDIDWEYPGGNGQDYKQVPNSAKVDEIETYPKFLAAVREAIGNKTLSIAVPGRRGDMIAFTKEQGPEIFKSVDMVNVMTYDLMNRRDNVTAHHTSVEGSLDTVQAYLDLGLEPEKVNLGFAYYAKWFTTDPDSDCKEHPLGCKVVKLENDDGSDNGKSGAFTFEKGVMDPPPADLKTSYNGKCGYSEGTKCPDGTCCSAYGNCGTGDDFCQAGCLSDYGTCKGISITDSWRRASKDGQTDDQQGGQYYWDEETNLFWSWDTPDLITRKFSDIVQAKNLGGVMAWSLGEDTYQFAHLEAMQNGVRQTTQQNAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB41</accession>
    <name>A0A1Q5TB41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinetochore protein Sos7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB41"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="3">
        <location>
            <begin position="73"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="286" mass="31915" checksum="8343C963F795E744" modified="2017-04-12" version="1">MADMADPAAVLQKLEQEQGDLKKQLAIIRISEPISDVGGSNPSPSKRGSDVSISNLNDPTPASLEADLSHYKELFSKLRFSYLEQVTKEKFLRAIVGDPPLVVGHNENVELETQLAEVKAELKSRKEEARLMIEEMETMGRELARRYKNVEVQMTQLSTLPDSIENLESTIAGLRAKQVAGMTSSDLRSSQNLPLPATMALLSEREAELAALNRQIAAVQNTLPRKTREAEAIERECTVLERRKIEAVTQAREAQRKKQQGESDGLEEMGRWYRGAEETLKEMVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB54</accession>
    <name>A0A1Q5TB54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB54"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB54"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="62750" checksum="9291D14A8E43BA2E" modified="2017-04-12" version="1">MQSYLQYRRLGDSVRAELDYAYTQRNTDSTVKTRSTSSSSSDSDSVNSIEDANQVTRDDDVAVTSNPESLEKSKTQRSEKTTLAHSLAGVDIQKQLASTNQPADLFIVGWDGKDDPQNPMNYNFSSRLIATLLVSALAFVVGAASSINSAVLPQNAAAFGVSDVVGSLVTGRNVVYTASLTLFMIFIMGSALAPNIGAQLAFRFLAGIFGCPPLTCAGGTIADLWNPLEKTIYFPMYAILSFGGPVLGPVIASYMGQTDALSWRWTAWIILIMSGAILVLIILFQPETYSPLLLKWKGKQLRRITGDNRFRSEMDMEKIALLSRISGAMKRQFLITIHEPIILLISLYMTVLYIVLFTFFDGYTYIFTDVHGLSQGLTNIVWVAMYVGISLATFLVFPIYKWTKKAFTQAAQAVNGADPAVDAHALDGVHTQPEIRLWFAMFGAPAIPISLFWMGWTDFESISVWSPILASSLFGFGTICVFISSYMYVIDSYSVYAASALGFMTVSRYCAAGGMTVVGIPFYQNMGVHWTLTILGCISALLVPVPYVFYMYGPVIRRWSRYAVVEESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBA8</accession>
    <name>A0A1Q5TBA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiotically up-regulated gene 9 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBA8"/>
    <dbReference type="OrthoDB" id="5330253at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38785" checksum="FEA4E1CDB3D0BCBC" modified="2017-04-12" version="1">MAGPQQSSTSPRRNRGFSVKSENSHKTNTSGHKSHLSESSQEKARRSLHTKADPTVAMNELQPMAVALEKSNMGSLRAMEHKDQYGNPITDPDWSNPTRPRFERPLDTIRSFEAAIYGTYTSTRPVSYARTDDAASQMGDYSRRTSYYGGQQHNGYSTRGYDQNGYGHNAQSRPDSMIDAYGGSSQAPDNYYPYNQSGNGKGNGNGNGRRPRHNPRMPSDQGGYANGNGGQYANQQSYDNVTSGSGSGYTDSYGQSTDPSSLNSSMDQLQQQALQQQRLDERAHAEYGYGGNPNINGYGKNLPSAPAAVADPGWNGAAPANGHLRKTPTANGKVQAQAQANGEKRKSWFKKRFSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBG9</accession>
    <name>A0A1Q5TBG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10362</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBG9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBG9"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="34041" checksum="5442FCA82114962E" modified="2017-04-12" version="1">MRPQVQLMIFSNGQAAPASNSATDEPLNSRNSLDATGDGSFNMFSRSVFRSLAVDLRWTAPSSISSAAPLRQRACLHQTALLRTQQQETQTQPSSPNPEAPLSAIPRAQTSQPEAQNEPKVPSFDPSNPSSVPQTRADVPIAKQPVAPTLDSPLEVTKSLMSRLPHLVGQSPHYIVAELHARPYLLTEGDHVRLPFLMPKVKSGDILRFNRASALGSRDFTMKGAPHLDERLFECRVRVTGVESEPMRIKEKTKRRQRHTKTARSKHRYTIMRVMEVRVKTPEELLEEGAVVVEDSEDTPKIEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBL8</accession>
    <name>A0A1Q5TBL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBL8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="127" mass="14538" checksum="62AFA49A1A621507" modified="2017-04-12" version="1">MEPSRGASLKTTEDSHLQKARCSLAKECDSKALDDSLAPQKWDIVRVHRSKALLKHGRFDEALSDLNPLPDAQEILEEALLQKSLAAYHLRRYQECWSTILECCQKYPKNIEAETLCSRVLDRVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCA9</accession>
    <name>A0A1Q5TCA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-hydroxypropionyl-coenzyme A dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCA9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11554" checksum="E3B41F0E5D702FBC" modified="2017-04-12" version="1">MPLTSAAIDIPTSYETLDLTHIKISHHPPGSPSATPVVVITLNRPEKHNAFTPDMADSLTQAYQMFHIDPRVKVVVLTGAGKMFCAGMDLDIGFGDGEGRAGDFRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD74</accession>
    <name>A0A1Q5TD74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="8797" checksum="13F9B346025978B5" modified="2017-04-12" version="1">MTEAVRAQCQLSARLPKVAIMLGGTGSPRHIVKNIGQISADGKQIEALTKIDKAVPQVLLHRLVGEYSIQQSLIYEPKGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDA4</accession>
    <name>A0A1Q5TDA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDA4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="34373" checksum="86DA3CF3216D3889" modified="2017-04-12" version="1">MIITVIKHLTSLAYPYPNDEQELDRLDMQHHMFKLVMEGKLYHVPLNNPKQILDIGTGSGIWPIEMATLFPNAAITGTDLSPVQPTEVPENVHFLVDDATEKEWLWEANHFDFIHVGHMTGAMESFKGLLRKAFTHLKPGSYLECHEMDPKPKCDDGTMPPENPDGYSAYALHDWFDLHMRASSEVEPSRQFRIAPRIERWMKEIGFVDVEQRVFKVPINTWPTDEKMKDIGKWSESNWLEALAGWSYKPFLGLGWSKIEIEVFLVDVRKSIQDRNVHAYMDFFVVTGRKPLADTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDE5</accession>
    <name>A0A1Q5TDE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDE5"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="216"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="339" mass="36187" checksum="641C7D9BC7400511" modified="2017-04-12" version="1">MSYPPPPGLKQTPASLPPRPPPSSNASKPSGYSAFTAFQPRAVASTKSAQSQPYRTHSPTISAPPVSSAGYASPSTGYGHYYQQPQPQSYQAQPQSYQAQPQSYQNGPFFYGPSGVPQIQNPFGSTPNQPHGARRGQNPGMDPETEAQIAQWQSAYSNPADEVGKPQGSSAVTPSAVGTPIPISTPQPEPTVTVARSGGGQTWTDQSLLEWDPAHFRLFVGNLAGEVTDDSLLKAFARYSSVQKARVIREKRTQKSKGYGFISFSDGDDYFKAAREMQGKYIGSHPILLRRANTEVRPVSNNKNQRKSNAGGAGGAGPKVKQDGVKKPGKTKGGLKILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDT3</accession>
    <name>A0A1Q5TDT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease FCY2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDT3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDT3"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="54704" checksum="F278CE94A9AC37AB" modified="2017-04-12" version="1">MATTNTTEDMEKKLQAEPVVSPVDEPEKTSKPTGIFATIRYYEEYLDRKMGIESHSLDRVHPENRNSPSAVVMGLMWASATMNISCFSTGFLGNQFGLSLGQTIPIVIFATLLGAAVTGWCATMGPGTGLRQVAISRYSLGFYPSSIIALLNVIEQLGWASVNCITGGLALSAVSDGRVSIAVGVVIIACVSLLFSFIGLRGVLLYEKYAWIMFFIIFMIIYGEAAHRANLAAPPTVTGMTASGNVLSLISVVYGSSASWSSIVSDFYVHYPVDTPKIKIFLYTTFGITIPTCIGMLLGACISSALGTNPEWAAAYENGIGEILKEIIYPSGFAKFLLVLLVLSGIGVNCIAIYSGALSAQLFAAPFAKVPRVIWSILVFGGILALGIAGRDHLLDVLENFLSLLGYWNTSFFAILFIEHYYFREGSLANYDLDAWNTPSKMPVGYAGLTAFLCGAAGWIVGMVETYYVGALAAKIGADGGDIANELALVFTTVSYLPLRTLELKYVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE98</accession>
    <name>A0A1Q5TE98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_9205</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE98"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="72"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="582"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKO98529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="782" mass="84193" checksum="80EB28E8F7666764" modified="2017-04-12" version="1">MHKGIMTSRLMPSGRQAMRSPFRSLRRTFATSRVFLQTFNSQQGFHSQLETVTPEVLSSLASKAVPQTLTEKIVQKYSVGLAKDKFVQSGDYVTISPHRCMTHDNSWPVALKFMSIGASKIHNPDQIVMTLDHDVQNKTEKNLQKYQQIEDFAKLHGVEFYPAGRGIGHQIMAEEGLAWPGTLCVASDSHSNHYGALACLGTPIVRTDAASVWSTGQTWWQVPSIAKITLTGVLPAGVTGKDVIVALCGLFDKDDVLNHALEFAGSEETMRSLPIDSRMTIANMTTEWGALSGLFPMDDVLKGWMKGKATTAAMGLADGPFKTTAAQRFTHEAIEELFANPLTADKGAKYAKELFLDLSSLSPYVAGPNSVKVATPLSELEAADIKVNKAYLVSCTNSRASDIAAAARVFKEAAEKNGGQIPKIAEGVQFYIAAASIPEQLAAEGAGDWQVLIDAGATVLPAGCGPCIGLGAGLLEPGEVGISASNRNFKGRMGSTDAKAYLGSPEVVAASALSGKLSGPGWYQTPEGWTGVKRGEGDGIAEEERMLTTEQALEKLLGQIDDLVADGEKKFAPEPTETKVEETSSEDSLTDVYPGFPERVSGEIVFCDGDNINTDGIYPGKYTYQDNVPVETMAQVCMSNYDTEFSTIAKAGDILVTGYNFGCGSSREQAATAILAKEIPLVVAGSFGNIFSRNSINNALMGLEVPRLLTRLRETFADSEGKALTRRTGWTLTWDVRRSQIEVQEGPDGAKWTHKVGELPPNVQEIIAKGGLEKWVKNAIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFH9</accession>
    <name>A0A1Q5TFH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFH9"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO98952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="278" mass="30777" checksum="867294C2A8EDA218" modified="2017-04-12" version="1">MSVVSLLGVKILNNPAPFTASYQFEITFECLEQLQKDLEWKLTYVGSATSSEYDQELDSLLVGPIPVGVNKFIFEADAPDLQRIPSSEILGVTVILLTCSYDGREFVRVGYYVNNEYDSEELAAEPPAKPVIERIRRNVLAEKPRVTRFAIKWDSEESAPAEYPPDQPEADRLDDDSNAYGAEEAELEAALVKELEEANKQGDDQEMEGGEVTAGNDDDDVSDAGSEDLEEESEDDDDELDEDEAADGDEDVEMGDDSEQKDESGKPAHQAQPEVMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG70</accession>
    <name>A0A1Q5TG70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG70"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="50929" checksum="C390A194C7C43758" modified="2017-04-12" version="1">MEKVLGYFYTGDYTLKLGSGRCSATSSSKNIRHQQSPSSAARPVVLVDNSSFPASMALSQSTSSSLIPVGSNEVDIEPSPTRNLALFHARVYGEGDYVLVEGLKTMTQAEFTTDLTKSLTKEDPKTAALDETLEELYSTRANYYSLRCIAIRQIVENIHVVSVKHGVPLRKSMKSIPDFAFDDQDYFQLLQAFQNAEEEEYGRHVQIWESQEPIRLPDTEPALMKKVLEFFYTGEYTFDFKTANGSSKPHTSSLHHASVGQSGSVPLATPNTGPSEPVPCVQQSSITTSGTNPEGATHQSEVNPNQSQENASSSGTPVTSENPTDTGSYDQFVAYCLTNPAYFHVRMYAEADYFMIDNLKQAAISAFEKDFAIYPRKKTFEETIRELYSIRADYQPLREVAIEMLVGYMHSTPKRVPFIYFDFMDSNPDFTLDLCMALVPIGVRPLANTRKAPTTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG74</accession>
    <name>A0A1Q5TG74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG74"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="353" mass="39503" checksum="472EFED62173DB77" modified="2017-04-12" version="1">MSFQSLPNELLYMISGQLRRPDLNALAQTCQQFYAFLNSTLYFDNIRLNHSSALFWAASTGSLGTIQRMLAHGADLQIRAESAAATQLGLNYLKSQNMTRKRGSARTRHTRSKKESLSFSACGETLLHRAAEWNQEAVAKYLLDNGCDMLSIDMYGYYPIQLAAHRGHESLVRLFLEKGFHPNTLSWARTDPSAIHSAVCGGYSGIVKLLLDHGADANLKGSSSNNEYSPLDLAFSEHWATKTQNILDLQNALGPEHMRGGQENCALLLIDHTAPHEIFEDDRYLLLAVKKNYVKVVQALLDLGIDPNTCLLGRRALRHAKDFKLKELVDLLEPLITPASQLKPKRKKRKTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG88</accession>
    <name>A0A1Q5TG88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG88"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000008">
        <property type="entry name" value="Similar to alanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067143" evidence="5">
        <location>
            <begin position="17"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Threonyl/alanyl tRNA synthetase SAD" evidence="6">
        <location>
            <begin position="791"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="837" mass="91490" checksum="D4F0AB6212789BBB" modified="2017-04-12" version="1">MLRPALWLTLATAVSSTPLSHSGAAVSSHPPTATLSPSKGPPKTVFVGRTLPEFDQDLFLGIKYADEPARFTAAELKSHYTSNDSNSGVYDLSTAGVSSHGNAVYYNATEYGYDCPGYGSDTTKLVNMGLIRSSEDCLNLNVIRPQNVGEEGLPVMLWIFGGGWSQGATADPRYNMSYVVQQSALNGKPVLGVSINYRLSAFGFLDSEEVRAEGNTNLALRDQRTAMRWVKKHIKAFGGDPDRVTIWGESAGAYSVGAHLVTSNGDNEGLFRAAIMESGNAVGPPYNGTEWHQPMYNRIVQRTGCTNATNTLQCLRDLPYQTFYNNAYEGLEWFATVDNNFISQYPQISYREGKFAKVPILLGTNTDEGTSFGTTGTNTDEDCIAQLISSKRWVLTRDEATQLLSYYPNISSLGCPYGWGNVTWPEKGLQYKRYESMAGDITMVAPRRMLAQAMSRFEDHVYSYRWDVAALNTSTTIGVQHFAEIPFVFANPVQNITALGSDPARLELGQLAARMWTSFVTDLNPNGHGAVLKLNMSSITKAGLVVLVKLWLFTRLAEYFCVSTTTVQGYKPTTTVQSLQPFSDLEEANQALFKSASNDDLILVTKDTIFHPQGGGQPSDEGYIFPAGTVTSTINNPENALLQVLAARMDATNNGQVLHLVRAMPSTTTPLQSLTPNTPILQTIDAEKRLLYSRLHTAGHVLGSAVRHLLESSIPNFDELKASHFPDSASCEFRGSIGGEHKDAIQAKVDEFISRAMPVEIQFWGEEDFKREGVEHLLPDPGLLGPGQDKFRVVRIVGAEVYPCGGTHVDSTDLCGGTVVKKISRSKGNSRVSYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THE9</accession>
    <name>A0A1Q5THE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THE9"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="8495" checksum="AC8ABB0F4769B6D2" modified="2017-04-12" version="1">MPRAVRGLLIECDPSIKAMILKYDEERHDYIVEDLDDENHLVIKESQLENLKARLDHDLDEKIMQLDESESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKN7</accession>
    <name>A0A1Q5TKN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44737" checksum="819BA6148226359D" modified="2017-04-12" version="1">MHPDNDGFSGSSFYELDPLAPDDLPETLGKDLSFLLRHNIFHPLSHVDIPSPLRSDFIVLNPGEPLSPSLGLLEKLLSEGRFLVAAHFTSSILTSSLISPTDTRLIFSLFYTRLACLELSGNTVLAAQESKALEDLNSTFYYIDPTFDGAETDKQHEKPLAHFPRHIVPWPLRVLAVRLQSIGFGDSRRSIGGLYEIGLEARREIMKKGSSENERKIWRERLADLGIRSVNALVEMGDLDAAKRSLEALQAADEDTEAMKLRKALLFLRIGDLDAAERVFGDSRESKEAALLQPLLSMSEGRYQDAVTEWRALHENTQRTDGALVGQNLAVCLLYSGKVDEARQLLEAQISANHSFGSLIFNLSTVYELCSDSAGKLKGQLAATIAGQPVSGQTNLDRPNTDFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL96</accession>
    <name>A0A1Q5TL96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL96"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP01000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="325" mass="35589" checksum="57D94F189312FF60" modified="2017-04-12" version="1">MASVPTIRIGYVPEHYLTPLHLALRSPAVSALPYKIVLTPFPSGTGHMITSLRGNEIDIAIGLTEGWVAGLTGKTQPQNPAEGGYKVVGHWVDNPLRWAIVTGRNRDNINGVPDLKDQRVGVSRLGSGSHIMSFVLAQQQGWKPDSLSTVPLGPFGALRNGVTGQDEANTSQEPNPTAEFFMWEHFTTKPFFHPTTEKPNPPLKNIGEIFTPWPSWMIVASTAVFPDPQNDSRLQELFQALDQGIKDFEANTAQVVKLLGTGELGCNYIEEDATEWLKDVKFTNATRGVDRNVIEGVVDILKMAGVIDTAMSNDEAIQRVIGIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM75</accession>
    <name>A0A1Q5TM75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM75"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000923">
        <property type="entry name" value="Protein transport protein (LST8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="538" mass="59725" checksum="7953E3CAFA171820" modified="2017-04-12" version="1">MANPAKKGRDVRMLGGSASNISFPESAPTLQPLHSPPPASAPFFARPAPIDIVTPAANARQARHHLPVIPDHILRNTAPSRPDSDFYLLPRRPTEPFDTTKHFYSLVASAVAATAPIRRPVTPELPDDPIKDLLEKTPPKCEVPFCPIMSVLLTTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCITPDKKYLAVAGHHNVKLFDAKSSNPNPLMTFEGHTGNITGVAFHCEGKWMVTSSEDCSIKVWDVRSGSLQRDYRHEFPVNDVVIHPNQAELISGDRGGMVRVWDLGESKCIHQLEPEENSSVTSVSVATDGSLLCAGSKKGNVYIWRMVQTEEKALMIPIATFQAHMDYLNRVLLSPDVKHLATCSADHTAKVWNLDPEYPPAKAALKEWKEKQEKRAQAGETENPNEALADANSNAHDLLRVFEQDRHLLRLTDNAPREETTQQTFAAQPDGPPMDPVNNTLFLETTLAGHQRWVWDCAFSADSAYLVTVSSDHYARLWELSTGTIIRQYSGHHRGAVCVALNDYSEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TME8</accession>
    <name>A0A1Q5TME8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TME8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TME8"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="27238" checksum="4D0CA9B367771674" modified="2017-04-12" version="1">MTDIVNKPTILLIHGAFTTAADWQSVISHLGQSFHILAPDLPGHGSAGGTFTLDNAADALYTLIQKSAVSKKAHIVGHSLGAQVAIRLAEKYPSVVDHMAVSGFEIYPSLPSSDRLSYILWTMSRVENLVPRPVIRWLMDGTDIGRHSPSLELCRQVAENMKIARYPAAWPAPTLIIAAGRGGLVPSYDHPEDAKKLASIGHEMNDKTLAVTHPLMRHPWNRQNPLLFANTVRGWIGGDYSVPVGFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRM5</accession>
    <name>A0A1Q5TRM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRM5"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="946" mass="106123" checksum="D5C4707BA31DDB8D" modified="2017-04-12" version="1">MSDQGSPARVPDGQPDPVLVGPGLTALKDEAYKAATNATPSLPTDKKHQMDSDVPSYFASIPGVNTEALDPSDKTPPPRRRKMSSGQDLLRRLSLTGDASPMSPELDPRAQHPGLKLSGRLISVAFCMPYKLYHQAGSDWELKPRSGTSALFDSFAHLASDETQWSHTLVGWTGEVEPVSDTKIPLQQIPVNAATKLPASASPASGIPLNKAAAPVPVNASQKPPSHPLIDGISVEKQDRERLDQQLSSGRYGRILPVWLSDESEEPEDTILLKDQGRWRRYAERELYPLLHYKQHGPTDGRSEQRWWADYIRLNQLFADRIAADYQEGDVVWIHDYHLFLLPSLLRQRIPNIYIGFFLHSPFPSSEFVRCLAKRKEVLTGVLGANMIGFQTFSYSRHFSSCCTRVLGFESNSAGVDAYGAHVAVDVFPIGIDARAIHKAAFGAPDLEKTVLGIRKLYAGKKIIVGRDRLDSVRGVAQKLQAFEIFLERYPEWRDKVVLIQVTSPTSVEEEKEDPENKIAGQIANLVSTINGRFGSLSFSPVQYYPQYLSQREYFALLRVADVGLITTVRDGMNTTSLEYIVCQQNNHSPLILSEFSGTAGTLPSAIHINPWDLVGVAGAIDKALKMPADQRKDQHLKLYKHVITNTVSTWSRLFLHRLLTNLSSFDQSVATPALDRGKLLKQYRKARRRLFMFDYDGTLTPIVKDPQAAIPSDRVLRTLKSLSADPRNAVWIISGRDQAFLDEWMGHLPELGLSAEHGCFIRKPRSDDWENLAERSNMAWQKEVIEVFQHYTERTQGSFIERKRVALTWHYRRADPEYGAFQARECRKALEDTVAKRWDVEVMAGKANLEVRPTFVNKGFIATRLVNEYGTEPGKAPDFILCLGDDFTDEDMFRALQKFDLPQDHVYSVTVGASSKQTDASWHLLEPADVISALQMLNSNSHQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0E4</accession>
    <name>A0A1Q5U0E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0E4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0E4"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP05946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="571" mass="64138" checksum="09C588D5983BB6F0" modified="2017-04-12" version="1">MAEAEGQSAQPHTRATRSSLACAPCRYKHLRCDGKMPACSRCTVDKKECTYHASRRRGNPRPKQTQESSTTTMSDRSPAPTFDSQGCFDLPPTLTLSENNADLPRRTSDSVLLGLYYEFFHAAHPCVLPRQFLNIYSKESAIQPLLLVLDYIGSLFATSIPSKPLHQDIEIYLASIRSRTRSITGFDVQAVLLYSIAIYWCNEPDTGVELLDEAIRLALELGMNRREFAQENHKNDPILAESWRRTWWQIYITDAHIAGSTHKFPFRCSHIEITIDLPCEELDYASGTIPRPRCLQEYDNREFFSDDEVGFSSYAELIGLTRGIDQALSPGATSDVQLYSSMCSNADTSVTAWHSLLPNSKRTILRPDGTVDEVMFKAEFIMHTYTVEIHRPMSSLAYSTIESVSRCAPLAPTDAFNCSNSAERQLHTMKCLAAIDKLDYILTLPTNINTHSPFIICMLANVTIAHLSACRFVLQGAKRTRCREKIRLTTGTLKRLSDHWILGKRTYREIGIIAREILCLMDKTPAAREPVMDQSFFTPSVDLSSLAFLPGPDFDFCAFFDSSITGGTEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1I8</accession>
    <name>A0A1Q5U1I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1I8"/>
    <dbReference type="OrthoDB" id="4519212at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="34267" checksum="BB1A54C395AAF3CF" modified="2017-04-12" version="1">MELVQPFIASEGLTDPEPIGQGLEFVVFKAKSDKHGYVALRVPRQKVFRNVNDPSTNAKQLIYQELKIYELLRGGPVPVPKPLCLLEIRDYPAMLSSYVPDDGSEVHPEELGRLAALIHSTQLPLDWNVELAAMEGTDVLTALVQRVLRRFDQLAKEEPSVNDWALTKNELEPIIVLLRHLPSCLLHMDLRDANLRICKGKPVAVIDWTNALIGPAAVDFFRIMELSRPGDAFINGYSTIKSPPKVTMDEEAFLRLDAALMIALVFISEAPDQKRREPSIRRVEELARMLRPANNSVHSSFSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4T6</accession>
    <name>A0A1Q5U4T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4T6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4T6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="307" mass="34324" checksum="365648F04E8B16F5" modified="2017-04-12" version="1">MMNKLRAAEQSYMSFDEMKEVISPRGELNRPSTVFLGRLTSLPGDIDHILNVRPDGARLFDGDPSTFTIDYEFHCNPTVKKPEAILRSVHISYPDRIWDATAVLHGHFSPHGKLDPEVERAVQYIAKNLWVEPKRSIRLLTRVDNNILSVKKVILKRISYHRCTNDRYVSDIGGGIAMHGLQLRVTEVQDLALTARQSNCDILEAVCESLDDMFTAHRQCQGVPTTIGDNHRNWCPIDILGIQTELITCAPASPTAQSINHYGLGSLLALATAVVENIDPVGYSNAGPAGDRNKGRRMKLLEWNSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5D9</accession>
    <name>A0A1Q5U5D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5D9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5D9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP07664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="161" mass="17302" checksum="36A1ED6C61A3A3C9" modified="2017-04-12" version="1">MLNLQASNLFSVQGRVVVIIGGGSEGYFSRPGPDYGQAIAINGASKTFVLGRREDALRETAAPARDGVIIPIKCDITSKESLVSAYQALIAHISHVDILFANGDLLGPLMRPPLPKADGTLPSLSEIRDELFNVPMEEFTNVLDVNVTGSYYTVLAFLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5E6</accession>
    <name>A0A1Q5U5E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5E6"/>
    <dbReference type="OrthoDB" id="4367766at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011959649" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="139" mass="14699" checksum="08A6DE01ACEDE7AB" modified="2017-04-12" version="1">MQFSLLTLLTVCAHVTALPGLLEHNGTCDQAACERIAQESGWLKKVSTLVFTNVYPFIHNSRLLKPHSSWCTSTVTATVITTATVTTTDAVTTTDTITATATVTITDTITTTDTVSVTTTCTQTATSTGGWATHGSGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA14</accession>
    <name>A0A1Q5UA14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="271" mass="29444" checksum="4A4FC62DFE3C00FE" modified="2017-04-12" version="1">MGGAGISVAIPLLMAQFQKSETDATQVLTLNFLFLSIGNIFWVPVAMKFGKRFSLLSSMAMQAGMLAWTAATPSFNGLLAARCLQGFAAAAGESIVPEIVADTTFVHQRGAMMSIYVVLISGGSAVGPLIAGFMTSSTAETWRSFSWLCCGVAIFNLVLILFLFPESNFDRPEFDLTVDQLRTLHHQHASKEADQTSSEERLEDVPEASSIPADYTISTPSIIEIMQPISYNVNVNFLKAFIEPVKLLVHPSVLWGILSYAVTLSPQVILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA28</accession>
    <name>A0A1Q5UA28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000551">
        <property type="protein sequence ID" value="OKP09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA28"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="9044" checksum="58641B073BD96D69" modified="2017-04-12" version="1" fragment="single">CPLYADLRQTFLDKIRITDLRDSTDSDAIVSHSQATRYVAEFILQTGLLGQFRHVEIEPEPPHSDETTGQDRLAGTGGEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA68</accession>
    <name>A0A1Q5UA68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000533">
        <property type="protein sequence ID" value="OKP09361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="342" mass="37100" checksum="E71350D488495DDA" modified="2017-04-12" version="1" fragment="single">GPNPVTKQANFEGGAMFGNNQEIILYGYLQNTTGDVPPNGHASFCSTLASSSDGSSHNIYIYGGYSGQNSTSAPYDDVYILSLPSFVWIKAYNGTSRHGRSGHQCFGVLPSHMLVVGGLYKDPSFCLEGGILQTFSLNDLEFQTTYSPELVEEYRVPNVVTRQIGGTTSVATTSSSSTTTPHSDAQEAHWIVPVTVGTVIPVAGITCTIILWVLLKRKHHLRPGQCRCSPGKRHWVHKFCPGTNQYLPGEIEGNPIEPEATRPVRTLSDMISELPAPCLPSRNSNDFSIAATPVQMYCDANLSYEAPGNDKLVELSSEAYDYPSDGAKAEDCDGKRSPLTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAE1</accession>
    <name>A0A1Q5UAE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAE1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAE1"/>
    <dbReference type="OrthoDB" id="3445803at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="90" mass="10452" checksum="8967869FFA6D7B76" modified="2017-04-12" version="1">MQNRLASVITVYKTAREHNGNFILLRHGLWELDGRQNSTAPYPGDNGDWTLWDSYLTQLCSDIKRLGMTEGWVIDIWNEPELVNFWPTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB81</accession>
    <name>A0A1Q5UB81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000465">
        <property type="protein sequence ID" value="OKP09738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB81"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="58"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="738"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="780"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="822"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="864"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="906"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="953" mass="104870" checksum="15C650C7313F7F52" modified="2017-04-12" version="1">MTAIECLDQKIDLGKLPVVQEAAIDSFANQHEDECLRGTRTRLLKEIGKWAKLLHGKCIFWLKGMAGTGKSTISRTVARSLKDTNNLGASFFFKRGDGNRGNAKKLFTTLTTQLMLRIPELRSGVQKALHDDPDIASKSLREQFEKLLLQPLLYLDQLGRQPRTAVIVIDALDECDHDQDIQNIIRLLPLLQKAKAVCIRIFLTSRPELPISIGFSEIADHEYQDLALHEIPEEMTEHDIHLFLQHRFAKIKRDRNISQAWPGDDVIQKLVTMSVPLFISAATVCRYIENSKWEPKSRLAELLTDQAKYVSRMDKTYLPILTRLLDDQESNEFEQRQLMQEFQSIVGAIIILTVPLSINALSPFLGISADQVSNRLDSFRSVLSVPNDRDQPIADKAPLQLYVAGLIFIPETSITRKLFKAEIPPWISQIPRVEERWSAELQTLEGHSGSVESVAFSPNGLLLASASFDKTVRLWSPATGALQQTLEGKSHGIRSVAFSPDGRLLASGSFDKTVRLWNPSTGALQQTLKGHSGPIWSVAFSPDGRRLASGSADRIVRLWDTESGALQQILAGRFHWIKSLAFSPDGRLLASGSDDKVLHLWDPKTGALQQTLKGQSQSTWSVAFSPDSRMLASGSADRVVRLWDPATGVLQMTLEGHLSSILSVAFSPDGRLLASGSDDKTVRLWNPSTGALQQTLAAYSGSIRSLAFSPDSRLLASGSYDKIVRLWDPTACVLQQTFEGRSHSIRSIAFSPDSRLLASCSDDKTVCLWDPATGALQRTLEGHSLSIRSIAFSPDGRLLASCSYDMTIRVWDPATGAIQHTLEGHSQPVMSVAFAPDGRLLASGSDDKTVRLWDTKSGTLQQTLEDHSHSTWSVAFSPDGRLLASGSSHKIVCLWDPATGALLNILEGHFSSILSVAFSPDSRLLASCSDDKTVCLWDTESGALQQTINASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC23</accession>
    <name>A0A1Q5UC23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Casein kinase I isoform gamma-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000406">
        <property type="protein sequence ID" value="OKP10013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="32927" checksum="CD1DDAA85FB6938F" modified="2017-04-12" version="1">MFYVNVADILKQRRPDTKKASGYYPRKSPADTDPLVENQEGKVTVKTERGSGLFSPQSSTLHHEYELYRQLSPSQGVPSVYWHGHHRFKRGHACGWRYYLVLERLGPTLHHAVQVRLGRPRLASSGLFFSLEEIADIGKQMVSTLKFIHRKNFIHGDVQPRKIAYDLSFKRMLLIGFGATQGLEPLPRQPAGPESSIVFSSRFRQQGDALSRRDDMESLGYVLVFLFRGQLPWQAHGMAADSILSMKSSIATENLCSGLQPLCEYMNSVKALASDQIPDYDNLSRMLGLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC74</accession>
    <name>A0A1Q5UC74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase TIC 32, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="270" mass="28901" checksum="0892A26BA819AC9F" modified="2017-04-12" version="1">MATTHSEYNEKTTATSVASAFADQIRGRNVVITGVGPNSLGEALALAIGSQQPAKLFLASRTEAKVQQVADKVRELSPTTSIEAVTLNLASQKSIHAAASKIQSQVDRVDILINNAGMMVLEKETTEDGIEIQFGTNHVGHFLFTNLLMDQMKNAAKSSESGSTRIVNVTSAGHRLSPLRFHDYNFEGKEVPVDERPPDGLPPMFSPSAGGYNGWLAYGQSKTANILFTVYLTQHLASAGIVSYSVHPGCDQGAATMLVAAFDPSLKCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCC8</accession>
    <name>A0A1Q5UCC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11296" checksum="A33A397A0C6B4C8C" modified="2017-04-12" version="1">MFPYSPTGANGHVPLVDLWLNPVVVEEAFRYVAGEKLYYERIPGSKSVPRPPFTALDIKVGDWEPSVEGYRNSASPIFPTFLYTCQWVFCQPGKADKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCL7</accession>
    <name>A0A1Q5UCL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10072" checksum="B6854F9BF5DB13E4" modified="2017-04-12" version="1">MSNKFGQDHLDTLVAMDNLAKTYMKQERWEEASQLIEQVMMALESSFGQSDPGRTDPGRTLATMTDLALTYNRQGRFEEAEKLDIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCR6</accession>
    <name>A0A1Q5UCR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000371">
        <property type="protein sequence ID" value="OKP10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCR6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCR6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="464"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="692" mass="77258" checksum="AEC75497F8BD0C82" modified="2017-04-12" version="1">MVAKAALLKERIEKAETAELPTRTDLRLRERGLDNFALRCFNTLSHDREISGVQVASALLNLSTYYTISHNFNRINLWWLRRYMRDLIEPVPIDAGEPSDAIAEEPCTYGGDTTVPVSIFDNYKWRGQQLACLTLFEYGMLIRTTKICDAIADDVSFDLSHPQSNTHVQRLARTSSQIATVTFNGQITEFQASEDAVPGGHRKTAANMNDLAEILLGLFVRWDQLPALFQQHTDALPTKRDACSRIWKVVEPTLVPYLRIFAANIDLLRKSREDSYADAKLRNASIPVDSLFDRDVDVLEVDNLDSDSDESLMDLDESVSVETLIAAYHSIAKCWDRETLVAARCVPSLAPAMTQNRGLPLQNLLPLNLIDNPAYPQEAVTGPAYQLDDFNLNVADAILEPMLIERQPINALPDYQPNVDGICTPVSLTSLVTETIPLNTKQRLVVERILGEALHWADHPYDASQRRQTLLYVGGEGGVGKSQIIKGILAGMDLIHRRDEVILMAPTGAAADNIGGNTLHTSLGISITRSQGRAMAARVRNLWSRKTIMIIDEVSMLDLSMLSVINNHCKTARSLDRGSPDFFGALPIVILMGDFFQFPPVRGPALWKEPRRGNAEDEDGRLLWHQFRNVIILDEQMRQSTDPPFQSLLHRARTSTLTEDDLCLLNSRVISSLVAPHLDAATTVVKLNSLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCY4</accession>
    <name>A0A1Q5UCY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCY4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="865"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134299" checksum="428ADA9AE31E7136" modified="2017-04-12" version="1">MYLAYDMLQLRTSSLANGLLIQRQKWKSTTDDIADLTEDQLLDALKALEEHRKIEDPLIRRLLHDVESIATRVPGSFAQKLKLRAEIRGLIIRYGMPAFWITINPSDLRNPLVLILAGVQLSGDVFAAANSAIRETTATSNPVAVAEFFHHVCKAIFEGLLASNTGHVGILGDVSNHYGVVETNGRGMLHLHALIWVRGNLRFRTLRKRVLEDAAFAASMISYLEKIIIQGVDENVPLDPEVNLPPMPPSARDVQSDSEFHLRLSYDSNLVARRKQVHSKHHFATCFKYRVNNPGKDSCRFGMPRDLVPSPRVDQLGVIHLARNHAWINPWNPALASCLRSNHDVSWIPTVAKSLSLIYYITNYAAKDDVSPWQMVAKAALLKQSLEKAKVADPPTEADQRLRERGMNNFALRCFNSLAHDREVSGVQVASTLLHLPSYYSVNLWWLRQYIRAMTHPQQPQTQSVSGPLGEEACTYKAGDTAPVSLFDNYKWRGRHLASFTFFEYCMLVRMRDKQRATATDFDFDSVHPRYTTHKQRLAQKPAHVATVTFKGLLTQFQTAEDSISGGHPATEAILNDVAEILLGLFVPWHDLFAILGQFTTEENIYSTVWAIVEPTLAPHNREFAANIELLRKSKEDCQADAKLRTSARLDDDFFDRHIADLEEGSFDSESDEHDEVFQIQSEDFTAETLIAAYHTVRQAWSRELTITAHRIPALLQGTAQGRNMPHINPRQLAFSTASINDALGVRFLATSVLQNWERRLKCLASTKEDASTAEELNSSFQLDDFDQDIGQGVLQPMLVESDVVHSLQDRRSQLGENPTAASLVSLVGQDIPLNKKQQLVVMKILSEALAWADHPYDSSRRKQLLLCITGEGGTGKSQIPKAILAAMDLLERKDEIMLMAPTGAAADTIGGNTYHTSLGISINRLRKGAMASRVRRLWTQKTIMFIDEMSMLDLTMLSVINNHCMIARSLDRSSPDLFGGLPVVILMGDFLQFPPVRGPALWKEPREGNDEDVNGQMIWHRFKQVIILDEQMRQSDDPSFYGLLTRARRAALTQRDVERLNTKVISSLLEPRMECATAIAKLNSVRHQINRVQIEHFAITRSQSICIFPAEHSRIKTTNPTKTRLRAEDLLQQPDQGTKIPFPGLFLYTRDMPAVILTNICSRIGHVNGAIGTMAGVVLDPTGKSSFFRKYLAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD58</accession>
    <name>A0A1Q5UD58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000350">
        <property type="protein sequence ID" value="OKP10402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD58"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="284" mass="32183" checksum="08805B007465C557" modified="2017-04-12" version="1">MEPAEYCQQTEKESASDLEGFSATMLQLSLWKLYQSGDHTDLDVICGDRVFKVHKAIVCSQSSFFAAACSGYFKEGVEAKVDLSDDAPCILERFFQFVYLGNYSDGEHFDDLPAVPALLSSIEVSQEFEKTYTPEDTDFNPEESPAKHQASEPLEYDSDFSHASLDKCIHEDNYLVKYPIGLFTSLRMYLIADKYGVPALKLLAGQRFIRTAILHWTTYEDFPAVIDELFSSTPSSDRLRHFIYSLIAEDYRSQASLRERLRPLVEKHVGFAIGLLDCLVARNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD97</accession>
    <name>A0A1Q5UD97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_4164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000347">
        <property type="protein sequence ID" value="OKP10440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD97"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP10440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="170" mass="18757" checksum="C25713AF439DD5C7" modified="2017-04-12" version="1">MASFARPSLLRQTLATTRSPLLRQNVGVSQVVAFHASARKQILPPLPQSIEGTMNDPVPVPSPHPMEGSYHWTFERAVCVGLIPLSIAPFAAGSLNPVMDAILCSLLVAHSHIGFQAAIIDYFRPQRVPKFYSLCNWLLRAFTLTTAVGLYEFETNDVGVTEALRRIWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDC8</accession>
    <name>A0A1Q5UDC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000319">
        <property type="protein sequence ID" value="OKP10473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDC8"/>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48401" checksum="DA465047C86F5BF0" modified="2017-04-12" version="1">MDQRGRKNGPYHGRDGGRWRAHGGTRRRTVLATLPPPLGEIVATIQLEDIDDSESQGDKRAQITNSQYLTSYNWITGADHHIVVPGEPPAWTPLPEHIQLREDSGQYYHDANAARYPTYPLEPMIQAILTERPEFPLSKVDIIGCGSTLGNLLRFARGKAPSFRMLVEVVGNTVFFIRRENSPNETIPDVRGYGHTFPEAYTTWSAGVRGSESHQRLVNYDFAGMKCVVRFEVDGFLPDLIPEDLKVQKNHPSETGDVKVDDILSSIQGVVISSVRSASKDATVKALKVSKRGHYIPQQAVFDLKTRSVKRMNVQTLEEELPRLWIRQIPNFVLAYHTFGKFNDIRVQDVREELKLWEASQQPSLARFASLLHMVVSFARSVDNGKFEIEHEEGEKILNIREPGGIVKSVLPTTLASKWDFEDMSEVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEI8</accession>
    <name>A0A1Q5UEI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA polymerase type-X family protein pol4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEI8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEI8"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="8">
        <location>
            <begin position="292"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="671" mass="75523" checksum="DED75594ECC98E90" modified="2017-04-12" version="1">MSNPFFGSSSPNEPAEETAKEKIFSGQPAIFILPTHLPMEKLHETENKLVRYGGILTYDITEASIILGKIGQKKRAALELRSRGVWTEDIPILGSAPSSTTSRPDQQPPAKRRKTDTAESAANSSIELVDLSTESESEEDGVRSRHDPAKHIVQSTKQPENTVVLLKLEWLEHSIAAGEALPWDSFVVYRGQKTARPPSATPAKSPSHRVTSAILQRAKEDAASQTIPDPSNHFYARRSREPPDGIGSQRQPPTLYRQTTSEHDEVLPLPPQPDWVRDHVLYACMRSAPLHPPNEDFISQLLKIRRIRELTLDEIGVRAYSTSIAAIAAYPYAIQRPSEIQSLPGCEAKIASLFAEFQQHGGCNHTDDDGNIAAANALETDPVLRVLDTFNRIWGVGAKTARDFYYRRGWRDLDDIVEHGWNSLSRVQQIGVKFFDEFQEGVSRHESEIIAEVIRRHANKIRPEADGKVQCIIVGGYRRGKQLSGDVDVILTHHDEDVTYSLIVDLVASLEEELYVTHTLSLHLTSSHREQQTLPFRGDETGKHFDTLDKALVVWQDPDFDAVKSTNPQDSSSRKKNTNPHRRVDIIISPWHTVGCAVLGWSGDTTFQRDLRRYVKKAHSWKFDSSGVRERTTGGQVLDLEHGGETWEERERLLMERLGIGWRPPQERCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF44</accession>
    <name>A0A1Q5UF44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF44"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="42347" checksum="FA74BC4B175EB2AA" modified="2017-04-12" version="1">MSDVQKSEVCVLSDGFAATRDPNFEVTWKAADTENPRTWPVWYRCFVVAATSFSTTIVIMYTTMYTSGLDGMQDAFNSSETVVLLGLTTNLFGLGIGSAVLSSLSEIYGRRPVYVVSVLLFGIFVLPVALAKNIETILISRFFSGFFGGVSISSGPGSVADVTNDQYRALALSCWSLGTMNGPVLGIVYAVLFLCFVAYPIVFEEHRGWSPSLAGLGYCGIGIGTAIAVISEPLIRKVINLHPSDPSTGRPAPEAAAWAVCLGSVLIPIGEFWFAWTAKPSIHWILPILAGLPFGLGNGLVFIYATNYIAGSYTVYAASAMAGNSIVRYGLGGVLPLAGSKMYHTLGPNWAGTMLAIIEVVLIPIPFFFYKFGHKIRLRSPMIVGEIRNRASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF55</accession>
    <name>A0A1Q5UF55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF55"/>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="22190" checksum="CFBBA2A1ED0E5A48" modified="2017-04-12" version="1">MSESHIPNPRSTPEEPQIYQTYEAATADLQRKLIRKKKHQRAQYQLISAIFNLLAIAQIIIGAAITALGPSGGEHMLAITILGAFNTSIAGLLALLKGRGLPQRLRRNMGELSKVLDFIQERATLLRYSSSAVSNSENSLLLQDAFQRYTIAQQIIERNEPDTYADGNMSEGNSFPGRTASKTRGGRGRQMDEEVGTSGEAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFS2</accession>
    <name>A0A1Q5UFS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFS2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFS2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000982">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="567" mass="61695" checksum="FD6BE5B16ED386D7" modified="2017-04-12" version="1">MLSESFVASTLSSAKSPTATLRDVGICLQEFQPSPQLRSTFKKSSTTTNCLAVTPSHIFSAQADKAVVHVYSREKGNQEALVPFPERIRSIAVASAKYGDVLVLGTEGGRLILWETCTGRQVATTASHLQPVTSIVVDPTSNFILSGSDDASIHVWSIPNILSFSKPTLGRDRQPQNTPIRTFSNHRAAITSLAVGHSAGRNNIAVSTAKDNTAIAWDYQTGRVLRTYLLPFSATCVALDPVDRAFYVGYEDGSAQSVDFYRSNSTQHPLHEPSLQSTPAQVSTEDRWLPPAADSGAAKAIALSYDGTTLLSAHESGKVLSWNIARRKFTASIADYTHPVTNLVMLPPSGLSSPSQDLKRTIHTIVKPRHDSAFADPAHAPGAVPAEYAFNTHVLASSQTKSRKPSQFSQALTHAYFPDSVIEEGLAELSALRQPGGSDIIRVASTAATPTTTQNDTQVADLEAEIAMLKKKVAVNDTARHANASEVTKLRVDLAQMQDYINEMHEKQEAAHQDKVQRQARKEERETKRREAWLAAEKKGRNGDAVMKKMEIDDGMFTSESDDQSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFZ2</accession>
    <name>A0A1Q5UFZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="49" mass="5478" checksum="3427F6058B6CC8F5" modified="2017-04-12" version="1">MLIQESCPPLLEDRIEGQTDIGFQPKPGPTLAPKLSESLEQENNTKDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG55</accession>
    <name>A0A1Q5UG55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG55"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG55"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="85"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="321" mass="34238" checksum="4DCD7D0C57E15B0B" modified="2017-04-12" version="1">MDKMTTKTGWAAWTAKKKIFVASLVALIIVALGVGLGVGLGVGLNNGGSGEGEGEGSGSGGTGTGGNGTTSGNGTVKWQPAVGVKWQIELLYALNDTSVDADVYDIDLFDNDKTMISKLQGLGRKVICYFSAGTYEKWRSDASDFASADLGNNLDDWPGEKWLDTNSNNVRKIMQTRLDLAVTKGCDGVDPDNIDAYDNSNGLKLTKDDAINYVNWLAGQAHSRNLSVGLKNGGAIIDSVLSNMQWSVNEQCAQYTECDTYAAFTEAGKPVFHIEYPKGDTTNNNQAVTTSQKSSACNAASAGNFSTVIKNMDLDNWVEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGJ2</accession>
    <name>A0A1Q5UGJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="238" mass="25545" checksum="06FDBB145117FD40" modified="2017-04-12" version="1">MSQLQRVVQQALELYGRIDVLLNNAGMCQIGGTEEVRSLWASAVDSSGSSFYAQALFGSHLRHVVYGCLVGLTSLGPYAASKAALSIFAESLREEVADFVIIVAAIEPGPFRSNFFKNMKGPTNPMSQYGGTALLQIQSSVIESDQTHMGDLKSGANIIVDIISHAGTGGSKIIPARIPVGNDAYRFTTAVCQTRENARGMEGLCELAVVLLHALRAKPPTYLSQMSLYRLLCACSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI95</accession>
    <name>A0A1Q5UI95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI95"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="140"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="376" mass="43475" checksum="5790FCE876992615" modified="2017-04-12" version="1">MSFLRNFFGTTTTAPEVQKEQKTPVRALPASWYTSQDMYELERRSIFSRKWLLTTHKHRVPNAGDWVEYDAAGFKFIVSQDEQGNIKAYLHDNNLSPVHVHIDRNGFIWVNLDSNETPEVAWTDDFDGVDEQPRFDYYNFDEYVFDHTWDMEGDFNWKILADNYNECYHCLVAHPDIPTIADLNSYYVKTKDGHIQHYGAQRQDQIDNGFRIATTYFWPNASCNVSPNFFFMQRFTPVSPTKSVMRYEVYRHKDATDEAFTLISDMYKRIMSEDKYLCIHTQKNLNAGVFVNGLLHPDMEQGPLHFQSTVREVVTQHFNKEQAAGHEIWPAKPPVSVDAAAVDETDITFRTGMDTYADADNLQESLASNLAPAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UII8</accession>
    <name>A0A1Q5UII8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UII8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="5781" checksum="E71A62158B1E8542" modified="2017-04-12" version="1">MDVQDATRLGRNSHRSSPASRDSNELALCRKAPSKIATVNGNARVGLKNAMADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ31</accession>
    <name>A0A1Q5UJ31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate permease A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ31"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="165" mass="17784" checksum="845F38192784D0CD" modified="2017-04-12" version="1">MAAGNTFGATVLSSYGGFWISIAITFIPGGFGIIGALEEADSGSPIMFYNAFGLYLMAWFIFTFMIMLCTVKSTVAFFSLFFVVDIAILLIALSYFFPTAQELPNEGLMKAGGLLAFLGAFLAWYNAFAGIADNSNSFFVVPVVHFPWSEKGRSARLRKTASGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ42</accession>
    <name>A0A1Q5UJ42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ42"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="256" mass="27671" checksum="0E669F72945A8CB1" modified="2017-04-12" version="1">MDPLSISASVAGLITISTQILSLVGAIKSKNNKGLESLSREVVAVRGILCQIQQIIQFQSTKPTKSAEWLESLNTTLDNCGDTYLTLQKELQGLQSTSKLDSLKMKVKWTLKENDIQDRLRSLESYKLSLDLLLSVQTSTTTTNIEEILVQVQKKLSLKPAETAAVKTPLSWRKKLAGFDSGPVDEKKTDDSGAVSPTLGSSASSVTLGTDSDTSHIIPGPKTAGWEEPGFYGISRDEGQLAPDLNSPDLTSVCEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ87</accession>
    <name>A0A1Q5UJ87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000200">
        <property type="protein sequence ID" value="OKP12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ87"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="17632" checksum="B3436D1356A8122C" modified="2017-04-12" version="1" fragment="single">GLRSALAHSAVVLRDRARSDRTKGSMLSITFENVMTDVFKSMVILALPSALFSTFGGMLLIHPRLLQENSNAHYPVGCFHFILSLAVLSVGGYVANRVHRYQGLFAGFNDKVSRFRYYKMMYYGGIGFAAYGCLVIIIIIIYVAFTPLEDDFQLFQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJA1</accession>
    <name>A0A1Q5UJA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000199">
        <property type="protein sequence ID" value="OKP12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJA1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJA1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="426"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116122" checksum="6F7F698C53C2F115" modified="2017-04-12" version="1">MAQFLREEEVVSADIIAIQEPWENPFQDNTHHPLKQTHELLYPVAAEMGGRARVCMFISKKMGEHTHLAHSRDCQEIRIKTESSRELRIVNVYNDQQQGAALRLLQDKLLPTREQKGVSYLVLGDFNLHHPAWGGGDTPHDAGAEDLLDLMETAGLDNWLTPGTITRDQAGSQSTIDLVLASYALREQIVVCEVDHSVHADSDHLPILTLLEINVPEAADPVKRRNWKAMDVGKFLTFASANLSVMRLPEEPTPREIDYAVNHLLDIVQQAAQASTPWAKPSAWARQGWTPECTEAIEASRRHFRQYIRTHSEEDWKEFTSVRNAKGRVIKKALKQGFRQWVRDTVDKGPRGLWKVSKWARMRDQSTSSNIPTLHSQEGDTPAVTNAIKRAPPDKAPGEDGIPNRVWKLLADNDRFVAVLTAIFDACMRTGYNPRHFQASITVTLRKGGPRDFRQPKSYRPVALLNTLGKILESIIATRIAWAVEEYGLLPKTHLGGRKGISVDHAIQLILDRVHYAWGRGKKVSMLLLDVAGAYDNVSHERLLNNIKQLRLGQFAPWIASFLRNRSTRIKLPGYLSDSFPTPTGIPQGSPISPILFLLFNAPLITACGLRTGIAKSAGFGWVDDVAVLVESESYYNNTITLEKILGKANRWARRHAAGFAPDKFELIHFTNRNENETAQGLAANDTTHIGSDIFDYATQHPEGNDQMPVQYNELSIQPTQSAKYLGVWLDKHLDFDTHRRRLLDKANGSLEALRAMTGSVWGASLVAMRKVYQAVVVPQMLYGISAWYCPAARPMPAWEMKRTVNEFTKVQRRAAILISGAFKSTSAAALNVELFITPVHLLMDQIIQESAIRIQTGATWAQPECLRRQRSPGEIKKGGWSPLEALRWKKDGILDPKGNVCDSRKAFVLAPWEARIPCAIDKDAEAARASHDKIEMESLQQAALDRTPTVLFFTDGSGYEGQVGASAVAPREGVFQRRYLGTSEESTVYVAELNGIEMAVAKFANQYRNNTRLIIFSDCQAAIQAVQKPKRSSGQLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK31</accession>
    <name>A0A1Q5UK31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthetase domain-containing protein C4F6.11c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK31"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="38873" checksum="BFE97D9A55DA7AD2" modified="2017-04-12" version="1">MSVPEEQPPALRLETPFVKDLQTKLHQSLTLRIEDVPEPPGYIQNQSAKIAVLFSGGLDCTLLARLAHDILPINEPIDLLNVAFENPRVAAAAAATSKQNTSSSSSPLSEPTSFYETCPDRITGRSAHAELQETCPGRTWRFIAIDIPYTETLAHRESVKRLMRPHNTEMDLSIACALYFASRGQGTISEPESGTIPYTTTARVLLSGLGADELFAGYGRHGVSFARGGFPGLISEIQLDVSRLGQRNLGRDDRVLSHWGRETRFPYLDEEFVGWVLRAPVWEKCGFGLAEPQGEDEEQTLRGIDKEKMGLRLVALRLGLRSVAREKKRAIQFGARTAKMEKGRTKGTDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKL7</accession>
    <name>A0A1Q5UKL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UKL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="724"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1356" mass="151482" checksum="A8047351657655CB" modified="2017-04-12" version="1">MSLNISRPKALDPSIQFEVPVLSMDPKAYVLALAIVRSCFEGESDISVLLVLAGEKQLKHFNCHLDPLLTVSQSLQLIVEGPYHGQAEDDQFISTSVLILDADGSDIDYASLQLNFTPPHILSIDQNNIAKFKFQEDIQSEPRARRMVKCFNKCLQQVQAYDKRQIADIDPTNDSDAAQIYTWNNKAIHVEYDLVHRVAFDHDRNAPAIHSWDGSFTFGALEQASTRLAHYLRKLGVRRESIVPLLLQRSSWAVVAMLAVLKAGGAVLALNADTPEERIKSILTQTKSSVMVVSPVLMYRVEHLPITRAVLSQELLQNIPHGVCVLDENHATDAAFVIFTSGSTGTPKGFTLEHGAFCTSARAINRALHMDEHTRCLQFASFSFDATQVEIFMTLMAGGCVCIPSERARLDDIEGAITGLSVNWMIMTPTLAASLDPSSAKCVETLCIAGEAPTEKVISLWADKVRLINAYGPAECCPISAIRDISATTDLPRNNVGWATENAILWIVTPHNHRILAPIGSVGEIMIQGPSLARGYLGNTEQTRERFLRGVDWLKGPSTVALPALYRTGDLGRYQEDGSIQFIGRKDTQVKIRSQRIELGEIECQVERVVDQKFAAAVETASSSSSGQIVLMAFLWRPHNEIAWGSKSSILIPDAEFTNTVSNIKERLRSVLPNYMIPNFFIPLDGVPRNMSGKVDRRQLRALGASLPHGALSLDCSVTTEAELPVTDAERKLQRVWTDFFGLETRTVNLKSDFFHHGGDSIAAMRLARLARADGLELTVTDILRCPTLQAQASIVEQRSRIKTSKVAYRPFIFFEESTYLRDEICSKIHVNRDMIQDVYLATDFQAAKLGTWTTKNRGGTNYVLLDFNPPRDKREVLMALNQTIGEFEIFRTVFTVLHRRVYQIILKKVPELEALEIGLGDTINQVTEEAIQEDKRRPVHLENSVLNIWALQERKRCHRLVLRLNQALYDGTTLISFIQNFCAACDALELGATSSLPEYLHSIKLHSDESSQKYWIDLLRGSSMTRIIKHSSPSYSHVLDGAVKEIIPSFKSQFSGITIATVIKAAWAMVLSQISGNSDVVFGVTTWGRNAPGGENAMGSCMDTIPVRVNLQTHLSPLDLVNKVQQQAIESIPHEMFGYQRIVDLCTDWRSWERLSSILLYQNLDQDIGSFPLNDGHIQVSELRSQSDRADLAVYSRPHGDGIWVEINYNTSLVSNSFASAVLTSLVSTIQNLGGPTSINISRPCATYRTPIDSQTKITSQTAAFENFEELHHDRYEKAEKLVADAWVECLLESSSTKTTFEDKSVPFYELWGSPLAAYALKEFWERRGIQIEVEDLYNHPTAYLQKQMVYNRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL77</accession>
    <name>A0A1Q5UL77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000155">
        <property type="protein sequence ID" value="OKP13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL77"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="60932" checksum="91B20AD2CAC4312C" modified="2017-04-12" version="1">MAQFLREEEVISADIIAIQEPWENPFQDNTHHPLKQTHELLYPAAAEMGGRAREIRIKTEPSGELRIVNVYNDQQQGAALRLLQETLPPTREQKGVSYLVLGDFNLHHPAWGGDDAPRDVRAEDLLDLMETAGLDNWLTPGTVTRDQAGHQSTIDLVLASYSMREQMIACEVDDSVHADSDHLPILTLLEINVPPAADPVKRRNWKAIDVEKFLALVSANLQNKGWMRQTISPHDIDRAVDHLLDIIQQAAQASTPWAKPSAWARQGWTPECTEAIGASRRQYRHYMRTHSEEDWDEYKLVRNAKGRVIGKAMKQGFRQWVRDTIDKGPRGLWKVSKWARIRDQSTSSNIPALHAQEGLAETNQQKVDLLRRVFFLQPPQADLSDIESTLPPNQLTFLAISQQEVTDAIKRAPPDKAPGEDGIPNRVWKILADNCHDFVAVLTAIFDACMRTGYNPRHFQASITVTLRKGGPRDFRQPKSYRPVALLNTLGKILESITATRIVWAVEEYGLLPKTHLGGRKGILVDYAIQLILDRVHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULA9</accession>
    <name>A0A1Q5ULA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULA9"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="307" mass="35477" checksum="0A627999488AE705" modified="2017-04-12" version="1">MSTVLTKTITEHLYHPLYTLWLPCQPGNLLSLASPESYEQADKILQETPSFQAYLHHIETNTTNPSSLLSVFAIPRLSQLNILRPEKYLDRKASTSVIFQDQRLYYPEMSGLIPGSTKDEELVHLALSRFLETLGSLVLGDMLKWQDEKYPFKPTMFGHGVMEARIDGSLVNCLTNEAFAILDARTVYRSREERKLYWEETAKMVSWIQHDLRKGRQSPPPRYLIISQCLEQIYLVVANFDKDYEEYIKILEAPVLSDNPRISCEMMEMTEYGPFNTDDAAHMKEFSKHVLAYYCEIQKTAFAEVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULG1</accession>
    <name>A0A1Q5ULG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophan 2-halogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULG1"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="566" mass="62537" checksum="43554CDFA4FB1114" modified="2017-04-12" version="1">MAVPQSCTVLVIGGGPAGSYAAAALAREGIETVLLEADKFPRYHIGESTLPSLRHFFKFIDFYDTFDAHGFYHKNGAVFRLAQAQPDAYTDFLEAGGPNAYAWNLIRSESDDLLFRHAGTCGAHIFDETKVDAIQFESDTNETSPDGVLNPGRPVSVTWVRKDGSSGSTSLKYLVDASGRHGILSTKYLKNRKFNENFKNVANWAYWKSDNVYGPGTHMEGSPYFEALDDASGWAWFMPLHDGTRSVGIVQDQKLATEKKRELGRPSTLDFYKKCLGMAPRTKELLSEAEVVTDVKSASDWSYTASAYHLPNARICGDAGSFIDPLFSSGVHLAVTGGLSAAATIAASIRGDCDEQTAGSWHSKKTVESYTRFFLAVSSATKQIREQYEPIIQDMDEEGFQRAFDLFRPIIQGTVDADTTSKMSQSEISKALEFCFRAFTYVPPELKDALLEKLKKLGAKSGQNDATAAKELDDIQKHLTADELQVLEILRSRRMIREDPFEMDSFTLDTIDGLAPNLVHGKLGLVKSEQAKIDRAHFYSPKFLDGKGPEIREGSVYLPTSKVQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM70</accession>
    <name>A0A1Q5UM70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM70"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="139" mass="15679" checksum="F5E9BA2B37B035A1" modified="2017-04-12" version="1">MRLAGDIRADGGGLMYLGNSVQVGREIEADFTRRAKDLSEEERLSAFNVHMEKYGQLSQNANEFGRAHQTNGGVGDRRWLVANYDAGDVVFHDPYIVHASSKNEGHDGRIRVSTDLRFYEEGSDMDDRWMQLWTPGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNN6</accession>
    <name>A0A1Q5UNN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNN6"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000025">
        <property type="entry name" value="Exosome complex component rrp43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="141"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP14098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="402" mass="43784" checksum="3D986FDEE10B76F8" modified="2017-04-12" version="1">MAAPAATAAPSVPPSLSLPPSQFARLQPHAYLLAHLSPPSASNQPSIRANGRAPSQFRVTSANAGSLTHTNGSAVVRIGDTAAVCGVRAELLHTEDIASWSVSQASGSNKRRRLADLGGKLSEEEDDEDTEEDRTHIEDLNLLVPNLSLSTGCAPGFIPGAAPSALAQSLSHQILSLLHSTRLVRADDLRVWYQPPNLGPEEPERHNEDEPMDVDAEQSATAEEKPREIKAFWVLYIDIMIISLAGNPFDAAWAAVLAALRDTKLPKAWWDVDNETIVCSDSVADARKLSLRGLPVSSSFGVFEADAAAGWRAHVIPDVAEQEQKGKKGFPERWILADPDGYEEGLIQERASIVVDKEKDGKTTIVRMEKNGGWTVDTEDLRQLVEISGRRWDEMKRILDQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNT7</accession>
    <name>A0A1Q5UNT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNT7"/>
    <dbReference type="OrthoDB" id="5346728at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="737" mass="84303" checksum="D26E392476623A41" modified="2017-04-12" version="1">MAPLNTRQYHSFSPSTPGHGKEIPGRPVPVNTFIDPTVFIELFVGTVGIFILSVLFWKVGKFFGSLTRHRVLCDGKLTTTRYARTWYGWVTTETHERNKAFIRRKFRYIREWLAWESPKRDYQWMWWDPGLEAMEERRAKRNRLKLVPEFLKSYEEMPAVHVPYPRSSIECHGALVTSQQSESSESIGNAPEIIDIAEPLSRISLNEHRFENSTASSISLEMFTPPSRAHTRSSDDRAEGSLRVDGRMVRHLLTLPTNVHPLPLSINSRRGPQKRASWAEEHSPRMRRLSNLSFVQNSSHVAELSSESSVHQNPQRSLEAPRPAFRSGSIPRKYRAWSAQMQVKATGIAQPHLRDSSGPPGTPLTVLLASYLSEQSACDIPQQALKEDPVVANPPFAKNSLTSSHDANPGKRRKLATSVDMDTELARFNTAPAIFRPPKKPTMLAAHTPNKLRHSWQDADTPDLHRPKLQATWGQSGMARARVEARNRYATLPNCMDGGVDGYVKDEQMSIAKLSDWEVRLMDQLKRKLGWVYNEMTPGQKPYHFALLANHWLNRETWLVIDPISRVSIDHRRQWGDPRFSPSDNENDRYPRLKYPPTTRKRAQIPRIDSWRAAVNQQRRVSGIRNAIRTVELYEDSAEEPPDGKIDPACWIFPKPPQGFEMSTAQKNAWYEGGAGWQEKLEDWQQVRRGYRLQKFVHEGRANRDRVKEVSSKVQKCCRTVSVKLLPKETGQPQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP49</accession>
    <name>A0A1Q5UP49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydroxypyruvate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP49"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP49"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF264">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="54"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="122"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="35626" checksum="91D0E7E57F99A93E" modified="2017-04-12" version="1">MAPGLTHDGDYPSTNGATSSKPTVYVIDQFNRTAIEHAKTIFNVILPEDEGFSEWRQKATALLIRGSFLTAKDIASCPNLVAIGKHGVGIDKIDQAACAKRGIKICNTPGANARDVAELVLALSMTVARGIRSITTRQMTKPVPKETCNGLTLYKKTLGIIGMGNIGRTVAEIFRGAFDAKVVAFDVFMPDNAWPHIPHDRVQDVEEVIRRADVLSIHVPLTDETRDMISYKELQMMKPDAILINAARGGIVNEADLTKALAEGHLWGAGLDCHEQEPPTFEKYSALWENLNVVSTPHIGAATTRAQTASAMAAVNNLYDYLMSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPB2</accession>
    <name>A0A1Q5UPB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPB2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886140" description="DUF7905 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="187"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="546" mass="61255" checksum="A54D770C5D65FF75" modified="2017-04-12" version="1">MRKAFLSMIFQLGLANLSISTDDASIASLFGRTTARPGRTEIFNDVCKKTGAFIQPPVESDTNKLVFTWPTDGPSPQECLGAALEKMDGIRTELQVYAYLDPENPAHIIVSNNEGFDSVSVVKFLRAAWVEGMGRTDLHIKKLMLAPLPVESSMYAVTLLRHNLVAKPYLHQVERQDAYTGRQVFAHKMNAMHTANFKEILQDMRTSLSMVNYFNGNLRMRFHFGTLILDRFMSPKTNETAVNLFDFADMIGHDQCRGRVVPGQKISMETLLNRFRDADDLLEPIGQTRPLSELELMEPTHSATIEFLGSPGSDFRLELYLKRIARAGEVEIKGHRWFKARHGEDKTLRMPLQLAMVDFGRADWQCDIEFFEVAAERLLSKSQRELASSIRFTSNGDNHHFVSHAAMNIWIPRDTPDAHIVKKSAIRFKVKRTNLVLELARFDIYRRTKFIKSYASASLYDPNWDSLLGGEIGVGGAQIQPHGAGLEAFFPSSLDSNAVEGAGLIEVLYVVQKIAELLGGSAIGLNQPPKDENVAAWMDVELGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPE0</accession>
    <name>A0A1Q5UPE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPE0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="11915" checksum="2A239E7FA18A9ED9" modified="2017-04-12" version="1">MPPEIKPELVRLYTSPHPANNILQHRHEHDSAERNAVLTKGALNPSYPHRQESRPNRTPRQTTYYSAHDDDVSALDPGPWTLDSTESGGAQQQQQQQQQQQQQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPN4</accession>
    <name>A0A1Q5UPN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOA4-independent degradation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPN4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="28091" checksum="4BD211D6567FBE5B" modified="2017-04-12" version="1">MNIVEWAFGKRMTPAERLRKHQRALDRTQRELDRERTKLENQEKKLVQDIKKSAKNGQLGACKIQAKDLVRTRRYIQKFYQMRTQLQAISLRIQTVRSNEQMMQSMKGATMLLGSMNRQMNLPALQRITMEFERENEIMDERQEMMDDAIDEATGMEDDEAEGEDIVKEVLDEIGVDLTQLVRSMTCDLDRVPTANRSTKQLGETPSGEIQKESAGSTRVAQAIGGGGGPGDAGDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPW5</accession>
    <name>A0A1Q5UPW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000087">
        <property type="protein sequence ID" value="OKP14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPW5"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48194" checksum="10F7FD928ADB319C" modified="2017-04-12" version="1">MSANPSTQGHNIIRLPPPSGLKVISPAPVYDVNKFPDERTRKLCALLEKGHVTVAPLRDPELILHSHLPHLLGSAYALGADSEQLNRSYEHEIKQLVPIARGFIRGDAISQENWRNFLNHKEYTVALQDFFDNEVKKKQGDWGKVLEEYLYSGPSPLINGYSGGLGHPFIHLAYAYEFRSKEVATQALSQGCTEYNPIHLFLDHPSPDTSAYKTNSLATIFEKVRTDSRLDNLFDNPGYNNLETLQEAQNLAILLEHWNAWEVADTLQQFEECCDLSVLLSISNGNPDVSFDFFNAHIMTVAHALRVLWHYLPPQRHVPVLRQYALFGIMTYVCQLRPKFTIESVEAVKTDGRDWQWVIDTALPDKWALDAHFFKVIRAPKAFEETFGRKDDFYLKAAIKYVTEFRGWKGHGKGVSGISPVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQB5</accession>
    <name>A0A1Q5UQB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQB5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="520" mass="57024" checksum="9A97E36552093F62" modified="2017-04-12" version="1">MGLFSVPELNTRLGTWRAYHLAAIVFISSFLSAYDSGVAGGILSFTSFQKDFGYTSKHQSKVSSLTVGLEQLGSFIAALFVYPLTNKYGRKIAIIGSTALFVIGVVIQVINTHSLAAWYVGRVVAGLGMGGQSVVIPMYSAEMTPKEIRGRCGSFYQWLYTWGVFTAYWVDYGVAKSTSIAGTSREWQIPVGLQLISGGILFIGTFTLPESLRWLLSQNRTDDAWKSIVWIRGGDTPKTRDEFAETQLGLQAERAEREGFSLRELLEPANRLRFLVGPLLFIFQNATGSSALAVFAPQYFKLIAGSGTDRNMLLTGLFGAVKVISCTFFIIFLAERLSRRITLVSGSALMAACMLITALIVDYIPTQSATSVTAAGRATVAMIYLDIMIYNCSWGPLPWAYVPEIFPTRIRALGLAVSMLAHWASSFCFSFASPYMIANVGANTFLIFMGFDIVAAIFCWFFVKETRGKNLEVAAGTEWEAAERSSSDDGEKGGVLNAEGKKVQLVSVHENFHANLKHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR69</accession>
    <name>A0A1Q5UR69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000037">
        <property type="protein sequence ID" value="OKP14961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR69"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR69"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="592"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118601" checksum="09E8444C8DB35B94" modified="2017-04-12" version="1">MGELVDRSRDASQTMIKNNVNVFGTITDSENEPLLGGECGKRLMPHVIDATAIAAPDVDCLFVPRTPGYPRDGWKPVSWAEVANAVNYVAHMLIEQAGTPTPGTFPTISYIGLEDPRYVVLIMGAIKAGYKALFISPRNSVEAQVNLFNKTDCNLLYYDQSLASMVKPWVAGRSGMKSVAIPPWDEWVNTTVAPFPYTKTFEEAEWDPFVVLHTSGSTGLPKPVVIPQGSFALNDLHRYVPDYKGNMPWLSTWGKFDNPRYLCTCPLFHTAGIAPTVLSGFYYNTPVIFRDPLVPFTGDNVIEWLQNSGATYTVLPPAILEQMSRSQVALDELSRLQVVAFGGGPIAPAAAASLLKNKVKLVNAIGATEYIYMPYYTQPDSSLWEWFIVPTELLGIEWRPFGEDTFEQVFIRQKKGHPGVQGCFYVFPELDEYSTSDLYRPHPTLPDHWTYVGRADDIIVFSTGEKLNPTTIEGAVIGHPGVLGAQVVGAGQFHAALIIEPAQHPPNEQEKQKFLDDVWPVIEKVNEQTVAHGRILRDYVFLSDPERPFPRAGKGTVQRAVATKLYADDIRRIFESSSDTNGSVAAVELDFSSETAFAEGIRDLVQQTLKLPALGVDDDFFTVGVDSLQVLQLARVLSASVKQSIEGRSIYSHPSIAKLSSFINSLARSSSNGTAVTSTEADTLALCSALVEKYTQNLPSPTTDKPLPAATNQTIIITGTTGALGCYLLDLALANKDISKIICFNRTSDARERQIAASSSRGLSTDFSPSRVEFLTVDLSTSSTFNLPEETATRLAATVDRIIHNAWPVDFNQSIASFEPHLRGVRHLIDFAATATKRIPITFVSSVSTVEQWPEPTLIPEQSLSDFTHASQMGYGQSKLAASLILDAAATTSSVPRNIVRVGQVAGPRAEQGQWNPREWLPTLIRSSVFLGLLPSQLGVLGSLGWAPVEDIAGVVLEVTTGQDGNGGYFHAVNPNLPVWEDVIVPAVTEFYGSRIERVVSLQEWVEALEKTAVGEVDLEKNPGVKLLDTYRLAAIASKGAGGEATAVSGGFATVRTEEASETMRRMEPVTAELMKRWCKQWQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URV9</accession>
    <name>A0A1Q5URV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URV9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="40784" checksum="610671C1710B642F" modified="2017-04-12" version="1">MAVSRRTSNTCGSERATRAQCTLQGRLAIILKPPLPLRSAQLKTVRKEQQPEIGDLRPDETSIHAMHGLTWKDDVTPDEKAFKVLKAVLAAGVNVWNGADVYGTPDNNSLHLMNRYFNIFPEDADKVVLTIKSGIKDMRISTMDCPPEAILAFVERANASLDGKKQVDKDVPIEDTVDALAELVKEGKIGGTQLSEVSANTIRRAAKGGKDRYGGSGNQLVGDICLRDGVAETCAELGIPMVAYTPLGGGMLTGQIKSLADMPANDYHRFFPRFQPENFEMNLQLVIKLEEMAAKKLCTTAQLALSWIKAQSRRDGMPVIVPVAGARSEQRVLENVTDIPLSEEYMAEIKAILDKFAVAGDRYPPAAAKLTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNL2</accession>
    <name>A0A1Q5SNL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">PENSUB_13657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNL2"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="19580" checksum="D0551294F56428B9" modified="2017-04-12" version="1">MFQSMRVSVRVPLRSVRWNSTAGPTLPPLMATLRNDLKTAMRAKDTPRLNVLRALISETNNAAKTASPIQTDIQLLSLIRKRASASKEAAQQFAEADRPDLKEKEDAQIAILEEYAGHVKTLTVEEVEAVITKEIAAIKEAGKKLEVGQVLKALFAPGGALDGKPADRKEVAGLVKKAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNR8</accession>
    <name>A0A1Q5SNR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNR8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNR8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO89622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14359" checksum="BC62787E12423630" modified="2017-04-12" version="1">MFSCSLLLRSCKPGMQHKGCAVHKLRCQTITRVLTAIFISPPIGIGSGVVAELSTPDEYARKVGWWVLMTILGTPAGPLLMGFVVQHTRVEFIFWIYAIINFLQALAYVFLGGETLRIREVDSDLTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNV7</accession>
    <name>A0A1Q5SNV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein DGCR14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNV7"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="492" mass="53144" checksum="CFB5DE2B51B1A78E" modified="2017-04-12" version="1">MASPPPSKALAKRSDGQLMPPPPPPKRIKRPATVLDEDIYTNTLSHIIARDFFPGLLETQAKQEYLDALDSKDKAWITSSKKRLADVMRTPTPGSNARRKTDSGSVAGTPMHFPAGRSDETPLGWGGDTPMSVASTATSATTSQGRDIPDVSNMGLTTFQAKYTSEDNESFNKVLDKQNTKKREKYAFLWNDNKIPSARQIAHHQREVKRITAAGGNPETSLVKRDDSEPAIKTDLDARPARPDAWKSRPDNGLMFLPSSIEDTHETLHQQAEAASRAGPKRTLYQNTRLLDVDAAAAADAASSIPASPSLSAIKDAIAGRPHLSESEASAVPGGETPRVNGYAFVDEDEPEPELEPGDQDPLEADWRLLGRSADTTPNPFQLRETRKREALHYRMVDRVSRSKRAEKAARAMKTPVTATPRFASSPRLDFGLRGTPGGVGVGPGGQGKMLTPAAHKLLSQVGGSTPRGLGSGEGKGKSGLGNMWTPTPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNZ3</accession>
    <name>A0A1Q5SNZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein plp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNZ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNZ3"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="227" mass="25144" checksum="500C166DFC3DB64E" modified="2017-04-12" version="1">MPTDSDDEALFAALENEEDPSYRDTRIQQLNAEFASSKTNRTTDTSPSAFAPTTLTHSDSYPTLQSDQSVLDHTTSTTRSLIHFYHPDFTRCAIMDKTLTLLAGLHHEVRFARVDVRNTPFLVEKLGIRVLPCVIGFKDGVGVERVVGFEGLGERGFDGTDSGFSVGVFERRMVSKGVFMGVKVGDENGAGSGDEGDESDDERRRGKGRKSIRSGKVRRDEDEDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SR34</accession>
    <name>A0A1Q5SR34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SR34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SR34"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="363" mass="39376" checksum="BD8515D9FF0C3B56" modified="2017-04-12" version="1">MSFVTGHLVRRGTELASAQFKDPEKQPEQISGALAACLALTVLVFGFAMWAVEYTYGGVVATLAAVEDSNPDVYVRIDNPPEEDPTKPFDPNEPELAAAARPQPVTSKLRTTIKHLRARAGFWSRFRGLAMYLTYGLARGIISSFLPSGSFITQFFVQSILSVLLSTWQMAWVHIVISEPSPKRFYQRIPSFRTWVKIAPAAALADVLTAAGFFLPMAIASFAGWLESNNGNESSMVAACRYLVVMGVPALFAFLISIPARVIFVRVAASMLPEEDETIVPFDRSFGGKVQPQIVGGSGHIGLLDAWTTFDWAARVRFAKVIGKTVAIEVALGLLAGILIFVQIITMAPNAIKHDGSAKPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRL2</accession>
    <name>A0A1Q5SRL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_13364</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRL2"/>
    <dbReference type="OrthoDB" id="10037838at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000128">
        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="387"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO90647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="46958" checksum="3FD83281A0831DF8" modified="2017-04-12" version="1">MASVSPPKPWERAASGGSALSSLPTAGNPAASTAMTTTSPSAVNPATTTTSSTAPSLPSRPNTLNSVVNSTASNYSPYGASRFGATTPYGGYGGYSSPYSRFGSMGSMYGGYGGMGGMYGGMGGMGGMYGGMPGQDPNDPNSLTNSFSQSTQATFQMIESIVGAFGGFAQMLESTYMATHSSFFAMVSVAEQFGNLRSTLGSALGIFTIIRWFRTLIAKITGRPPPADATSLTPAAFAAFMGGRSAPATLPDGSPAPAKPSKKPFFMFLVAVFGLPYLMGKLIKALARSQEAEAKRRQQLVGPNGEPQSAAMDPAKLDFCRVLYDYAPETQESNGIDLAVKKGDIVAVLSKSDPMGNASEWWRCRARDGRVGYLPGPYLETIQRRPAQQAITAGSEPVTRTSTMKSGAANERTQSLSSISKVGHQPPELKGKMGDISPESFQKSTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSC4</accession>
    <name>A0A1Q5SSC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_13195</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SSC4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000007">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000207">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="431"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="523"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="615"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="707"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="781"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1288"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1310"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1348"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO90894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150050" checksum="3A29CF5712C2D386" modified="2017-04-12" version="1">MAGADETLVAATAVLQSLARDEPTTGSASPPFDFEFPSTNGAKSSKLPGEPSPAKVAFEAELEALVRRVHHLEFQAVSHHKLPDNPQQTTPSAIGSNEKDPDFLWTFGLDRLSSGQGSDSSYCLTQQQKLNQPGRRQRTPSAPEEKSPRPPQQPAPIGDLDEDDTDEEDETGATRLVREEDISILRNHVQKQAEEISFQKDMLAQVRDELQKQEEHTRRALTKVENEDVVLLERELRKHQQANEAFQKALREIGGIITQVANGDLSMKVQIHPLEMDPEIATFKRTINTMMDQLQVFGSEVSRVAREVGTEGILGGQAQITGVHGIWKELTENVNIMAKNLTDQVREIAAVTTAVAHGDLSQKIESRAQGEILELQQTINTMVDQLRTFATEVTRVARDVGTEGVLGGQAQIEGVQGMWNELTVNVNAMANNLTTQVRDIATVTKAVAKGDLTQKVQANCRGEIAELKNIINSMVDQLRQFAQEVTKIAKEVGTDGVLGGQATVNDVEGTWKDLTENVNRMANNLTTQVREIADVTTAVAKGDLTKKVTANVQGEILDLKSTINGMVDRLNTFAFEVSKVAREVGTDGTLGGQAKVDNVEGKWKDLTDNVNTMAQNLTSQVRSISDVTQAIAKGDLSKKIEVHAQGEILTLKVTINHMVGRLAKFATELKKVARDVGVDGKMGGQANVEGIAGTWKEITEDVNTMAENLTSQVRAFGEITDAATDGDFTKLITVNASGEMDELKRKINKMVSNLRDSIQRNTAAREAAELANRTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDDLKPYTREMLNVVHNLANSLLTIIDDILDISKIEANRMVIESIPFTVRGTVFNALKTLAVKANEKFLSLTYQVDNTVPDYVIGDPFRLRQIILNLVGNAIKFTEHGEVKLTIRKSDREQCTTNEYAFEFSVSDTGIGIEEDKLDLIFDTFQQADGSTTRRFGGTGLGLSISKRLVNLMGGDVWVTSEYGHGSTFHFTCVVKLADQSLNVIASQLLPYRNHRVLFIDKGQNGAQATNVMKMLKQIELEPLVVRNEEHVPPPEIQDPSGKESGHAYDVIIVDSVDTARILRTFDEFKYIPIVLVCPLVCVSLKSALDLGISSYMTTPCQPIDMGNGMLPALEGRSTPITTDNSRSFDILLAEDNDVNQQLAMKILQRHNHNVFVVGNGLEAVEAVKKRRYDVILMDVQMPVMGGFEATGKIREYERESGLQRTPIIALTAHAMLGDREKCIQAQMDEYLSKPLKQNQMMQTILKCATLGGSLLEKSKESRISSSGEMHPIHSSVPDNQNQQQRSQKQQGLPSPPRPNMETRAISTTGPIGRGSVAEPEDKDEEMIDDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSD8</accession>
    <name>A0A1Q5SSD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSD8"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF15">
        <property type="entry name" value="PHOSPHONOMUTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="32580" checksum="F8B1B49C2E924C97" modified="2017-04-12" version="1">MSLGSGASNLRKILADPNGFVTAPGVYDGLSARMALGAGFDALYMTGAGTAASVHGQADLGICTLNDMRANAEMIANLSPSTPVIADADTGYGGPIMVARTTEQYARSGVAAFHIEDQVQTKRCGHLGGKQLVDTATYTTRIRAAVQARHRLGSDIVVIARTDALQSFGYDESLARLRAARDAGADVGFLEGISSREMAVQAVRDLAPWPLLLNMVEHGSTPAISAQEAKEIGFRMIIFPFATIGPALTAMREGLEKLKRLGLPGLDPELTPQMLFRVCGLDEKMKLDAEAGGAAFEGGVDLEEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSF0</accession>
    <name>A0A1Q5SSF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="150"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO90882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="41538" checksum="FB0CFC3163D2572F" modified="2017-04-12" version="1">MWDFARLYKAWSEERVLPWEFTKVPYALVNPAMLVKLVPNGNITPSLSHDCFPFLFRACIMMRSMGDQIIGLDRKEIVIGAEIPPIKVMTVEVRYGLMNQLEHNARYRALIQALSSSGEVDDGANDLDQTAGRQNIDVTRQLALLGFNLLLDDFLRGVDGKDTVSEAIAKLIGAPDYGFTAFWSPIICWMVEMVLRRLGIRSVSITAAKSQDERNDAVLEFTTPDNLCQVMNTTYNCGGTGLNLYGCCSIVILLEPAPNFNLETQAIGRVHRIGQTRPQKAYRILQDHMINRAITSNNFRKMLLQLAAQYPDLFDQELQARVAELEAKRKGKLRDHKRADLLNNICQPEWIGALITTCNMQSDIYLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUE3</accession>
    <name>A0A1Q5SUE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Na(+)/H(+) antiporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13044</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUE3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUE3"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO91637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="553" mass="61434" checksum="5D3B77F650AD76C7" modified="2017-04-12" version="1">MPTLALINFNIVCATLGGFISLFGLVSYLCKERFYLSEALISLLAGVAFSPHAANFIRPDDYALHSEQNLEAITLHFTRLVLGVQLVLAGVQLPKRYLQIEWRSLSLLLGPGMAAMWLCSSLVIWAMVPNLQFLHALIVAACVTPTDPVLSNSIVKGKFADKHVPRPLQRIIIAESGANDGLGYPFLFFGIYLLKYVGMNGEGYSGWAGKAMGQWFLETWLYTIILSVVYGIVVGWLSRKLLHWAEEKRYVDRESFLVFAIALALFIVGTCGLIGTDDLLACFIAGNVFTQDDWFRLETMDDSLQPTIDMLLNLSVFMWFGAVCPWSSFLNNDIIPIYRLIFLGILILLVRRMPIIFAMHKYIHQIEHVSHAAFVGFFGPIGVGAIFYLSISREFLREITVDGKVREDAQQVMDTINVVVWFLVICSIVVHGLSVPVGKAGYNLPRTISSAISTSTVDEPEPVPISNIRHTHSTATPRANLSGPSHRSRKRGAQHESPHPPLFRVGRSVIRSRSPNRQLGVGSIDEPERPVNLVTHDTVVAVNEREQGSMSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUS7</accession>
    <name>A0A1Q5SUS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-specific adenosine deaminase subunit tad3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69068" checksum="228DC61F37D47D0F" modified="2017-04-12" version="1">MDLEETIKAIKPLKGEVVPIRTIQETRPPEDFTDAYVAEVNVKAASKVIKAIDAAFPRDTTLPAMSHLRRFSKRTMLPEHLAAAIEADGSAPANNGQTIFVVIPPPLPEVETLQALLAPFAPLPRRRSSATPPANSPRPSSPISAPGSPEPQPPKIRVLKTRIPIYPPFNTTQADYWTRTMWPVVFNPAAPRSTVAPPPQILNRALDSIKPRAGYYLSLARKVAEESKQSGRGRGVGAVIVDPTIEDEIEIQAWEDCTDPNEHWMDAVLSVGGDVRYARSEAGAASQADKHPGVAPNPACTKYDADIEGGPDLHALMRATELVARRRREDGDHLAQYGDSALPVVASDPQLSNKLSPLESYFLYEISGHTTATEHDHTIAPPLSLKKRKHEEPNPESSTSFWAVTPEATTPVPVDQWADPKPVIPLVPHKPVNGWPSTAPVGASTATEPVDLWNTTTPAVPKTTPLPPSSTAPGAPGIPAPTTAHANSSPSNSGTTSPPQTSRIRTRSQGGYLCTDLDIYVSHEPCLCCSMGMLLSRFRAVIFPRAGRMPSGGIASEPVVKPTPMDYDSGWGAEEKIDEEPKEAAKTEDRLYYGLHWRKELNWRALGFEFVEDDEKEDEGAVSGLNDDDENLNFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWB7</accession>
    <name>A0A1Q5SWB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWB7"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39382" checksum="E0B6051817677EF3" modified="2017-04-12" version="1">MSATTTVIETTQANPNLHGFGRMRLDGTDRRWGDFRDDLARDGYAVVKGAIPREQALKYADEMYSWLENFKLGFDRNDLSTVHKDNLPLINEKGMCLHYALPHENFVWGIRSEPGVVSAFEKIYDDEDLIVSFDAINFQFPNRTDIAPNKPWPHQDQNPEKHGFRCMQGLVNLLPNGPEDGGLIVCKGGHLVSEEFHRDMADEERIPAWTPEWYGFTDRGMKWLEDRGCKWEKICAEPGDLLLWDSRTPHYNLSPKKNQPRFAIYTCFMPVADATQEDLIRKKDAFDRRVGTTHWPNAKHTGSNVAQRDGKEDPHNRDRPVNEPVLSERAFKLTGIPYIKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ75</accession>
    <name>A0A1Q5SZ75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_12371</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="18">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="510"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="628"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO93308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="880" mass="98844" checksum="494B4F2500A1709A" modified="2017-04-12" version="1">MAMTTTQTLVSSDKLSFKKSHITFHDLPTPQEIDLPLPPPSFSPTEILDIDKGTPDHHVPRDSRLIRLTGVHPFNVEAPLTTLYNQGFLTPPELFYVRNHGAVPQVLDKDIPDWTLSIEGLVENPITLSFRDILEKYEQITAPITLVCAGNRRKEQNTVRKSKGFSWGPAGLSTALFTGPLMADILRSAKPSRRAKYVCMEGADKLPNGYYGTSVKLNWAMDRNKLIMLAYKMNGEALTPDHGRPLRAVVPGQIGGRSVKWLTKLIVTDAPSENWYHIYDNRVLPTTVSPEMAAQDKKWWTDERYAIYDLNVNSVAAYPEHEETLDLTTSGKIYTAKGYAYAGGGRRITRVEISLDKGKSWRLADIEYAEDKYREYEGELFGGKVDMWQRETSYCWSFWSLPIPVADLKDSDALLVRAMDEAMTAQPRDMYWSVLGMMNNPWFRVMIHREGNLLKFEHPTHPAKAGGWMERVKKAGGDLTNGNWGERHEGEEPVEVEHVKEINMKKDGVSRQISLKELKENSSSEKPWFVVNGEVYDGTGFLEGHPGGAISITSSAGLDVSEDFLAIRKFIEAHTLRNSANSLADSETAKLMMPDYHIGTLDEASLKALNSNTEAVSDEPRPEFLQSRVWSKLKLSEVKTVSWDTRLFVFDLEHSKQTLGLPIGQHLMIKVNDPVTKEAIIRSYTPISDTNLEGKMELLVKIYFPTDDVPGGKMTMALDKLPIGAEIDCKGPTGRFEYLDNGRVLISGKERHVRSFKMICGGTGITPIFQVLRAVMENPQDPTKCVVLDGNRLEEDILCRSELDSYVETDSEKCTLIHTLTQGSDTWTGRRGRISEDLIKEYAPAEESSMVIICGPEAMEQSAKKVLLAQGWAESDLHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZA9</accession>
    <name>A0A1Q5SZA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZA9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="170" mass="17953" checksum="392741D06488B593" modified="2017-04-12" version="1">MSSVDVFGPEADTSDEAAGTEELIEGDRDEEGRLEADDELSKNEPVNDGPGEDEGVEKKKEEEPEGMTEGEAVETEDVTEVRINGVDDGRTGEDTGLDDRLEEDGIDDPISGVEEGVQDGDTGTEESGTGEDEEETRTEEGDIGVENGDTGVEDGVPVVYGVGVEVEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2D3</accession>
    <name>A0A1Q5T2D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2D3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2D3"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="285"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="570" mass="63283" checksum="3245A831F6CCC490" modified="2017-04-12" version="1">MSEQFNQRRDKRKISSWFLYGTLAIGLASAFTALFNNTVRSSNPPELDIYSPGAEHGICQQVPKLSPRNKQVEQYVREKVESVEYHGEIINKLSGIIRIPSESYDDLGPIGEDDRWNIFFQVEDYIKTCYPTVFDNVKLDHANTHGLILTWEGSVPPSEAKPILMLAHQDVVPVLEENVKDWTHPPYDGHYDGEIIWGRGATDDKGYLISIIESLDLLIQSGFKPKRTVILAFGCDEEISGENCGRPISDFLHEEYGDDGIYLIMDEGSTGIQREFGQSFAMVSVAEKGYLDVGINVSSTGGHASNPPDHNVIGILSEIVVAIESNPFPGKVTPKNPMFRFLECGAVHAPQSSFPQAVRQKLSLVAEEDSASQEQLAQTLNDMRYFFKTSQSVGKINGGVKINAIPETASTMVNLRLAVETSIAEVEAHYESLAIPIARKHGMAFAGFHSPCSTAEKRKICMFGVDALEPAPVSPVDAEPYRILSGTVKNVLKSLGPDDDLIVTPYLMPANTDTKFFWALTKNIYRFTPVNLVENLNRAHTTDEFIRADEFVREPLFFATLILNTDDIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2D8</accession>
    <name>A0A1Q5T2D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2D8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2D8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="65" mass="7005" checksum="5971AA22A6E2AA66" modified="2017-04-12" version="1">MPCILHYQWSNNPTALQDPLNKALASIANAILWASSAWYAKTGVNDNAVLVGLSAALHSYSVFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2S8</accession>
    <name>A0A1Q5T2S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2S8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7511" checksum="22D4B1561CA6CE0B" modified="2017-04-12" version="1">MPNTAAPPALLPPSSNQGLGSLDKEQSPGEYSSGIDSDSELVGPNGSRALKRKRPLTVSYVPELIMPHTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Z2</accession>
    <name>A0A1Q5T2Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Z2"/>
    <dbReference type="OrthoDB" id="5231661at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12228" checksum="8C256B6DD52BDFFF" modified="2017-04-12" version="1">MVPLGSPGRQSRLPPTTIFSSPAFWMRAAYASLSNKPPSPVKPGSAKTHNNERMAADEVQAPSVSFEGLGISRNMKLFLLVILGVFGSVETYFWCKAIWIWWIGGEEGGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4R0</accession>
    <name>A0A1Q5T4R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4R0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4R0"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011814984" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="57517" checksum="11B999C7687E4155" modified="2017-04-12" version="1">MIPRVAAIVAALSGLVPGALASRTASCSKSTFKSLDLKGIKITSLDVTPAHNYSTSGRNATGGAGVIPDIPGSPAPTVDICFIAITYTHHGQKDVVNAYIGLPLNAKDWNSQFLMDGGGGWYAGGQPEVLSPVLAGYASSSTDGGHGVTASTGDWALTKKGDIDWPTVWDFSSVAIAEAAILGKMATKMYYGSEPKYSYWHGCSTGGRQGHAMAQQYPELFDGIVGGAPAVNWDKFAPAGFWGPLKAQLLGVQPPICVLEAFTNAAIAACDELDGVKDGIIALPGQCHFKASSLIGQKVQCVEPNGEITITDKMAELVAAVWDGPESENGRFEWYGFHYDSNLAAMIGTTCTSIDDCTISPFFVSDDWVKVFLARDPSFNTSTLTHQDYDRLFHQSVRQFSSVIGTENPDLSKMRRAGTKMIAWHGMQDQLVPTNGTVDYYNRVLELDSCAADYYRLFLAPGVTHCGFGPGFDPVETVLGTLKAWVENGTVPDRLPATAVAVAPSNTSTTRTGYLCPYPEVFTYTGGNPNEASSFTCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T608</accession>
    <name>A0A1Q5T608_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T608"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T608"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="82"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="511" mass="55511" checksum="28EC40D52FA39613" modified="2017-04-12" version="1">MATNGDFSDESLPGSPNLDATNAQDFDDQEPLDEKPLKSAMKKSAAPPPEAPKRPWLPEQPDPTTLDLSTLTPLSPEVIARQATQNIGTIGHVAHGKSTVVKAISEVQTVRFKNELERNITIKLGYANAKIYKCDNPACPRPTCYKSYNSAKEIDPPCERDGCEGTYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNETCPQPQTSEHLAAIEIMKLSHMVILQNKVDLLREESALQHYQSILKFIRGTVADGSPVIPISAQLKYNIDAVNEALVSLPMPIRNYSETPQLMVIRSFDVNKPGAEIDELKGGVAGGSILQGVLKENDEIEIRPGLVTKDEAGNIQCRPIFSRIESLFAENNPLRFATPGGLIGVGTRIDPTLCRADRLVGFVLGHRGRLPAIYTEIEVNYFLLRRLLGVKTADGKQAKVAKLAKNEVLMVNIGSTATGAKVLGVKADAAKLSLTSPACTEIGEKIAISRRIEKHWRLIGWANIVAGNTIEPIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6M5</accession>
    <name>A0A1Q5T6M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6M5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6M5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="110" mass="11690" checksum="A9E07567C30F6D37" modified="2017-04-12" version="1">MAEPEELEDDLFADLYDADESTNRATSAVEAPKHSEPAPAAVPAPLAQESAVPSYDPSPVDTYQTYAPPQQDYSSGAHNGADHGHAQHPTTAHHVDQEEPRSGTGIKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6P8</accession>
    <name>A0A1Q5T6P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid beta-fructofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6P8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6P8"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="445"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO95910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="636" mass="70930" checksum="E7820AF304C2A1C1" modified="2017-04-12" version="1">MKTNTIATAVALGAGTSQAWGQSLTVDMIDKLSNNTLFTRWRPTSHFLAPAGWMNDPCGPMYDPVRNLYHLHYQFHPNHVNWGNISWGHATSPDLITWTDVDHLPNDGIPAWKDDQAQSIGTTNLTSKHNPPLYNHLGIFSGTSHSANLTGGVDGTFLTFYTSVSRLPTSWNKPYLKGTESQSLAYSTDGGVTWEEYENNPVLSEPPTNWNITGWRDPFFSPWQEMDSFLNLTEPHWYAVFGSGIKDVGPRIPLYRAPASDLSDWTFLGALWEPEKNSTLGSLEETGSYGFNFEVSNFYSIGDRYFVSMGAEGGNVSFHQQRWSLWNEGTLSVRENGSVAFKPVSGGAGDWGLLYALTTFNDTKNNRRIQWGWAPEDMNDFAITQQGYQGSFALPRELFIKDTPNVIHNATNTAPGNARYFPNANSTWTASTLGVRPAADVVNGLRKGSTHTKYPCKSKNINLPTKLSKSYQLNVEIKHTTGLAGITIAASPNREEYTNIFFNPSNNSIAVDRSHSSLIDKFANSTHEGYFKPYTLRQHNGKNTTESIQMSIFVDGSLVEVYVNERFALTTRIYPSREDSTGVALYSAPGAKVEYSNVEIWDGLLNVWPERPENSSSLLVFDTAEETGDYVWWTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T778</accession>
    <name>A0A1Q5T778_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000700">
        <property type="protein sequence ID" value="OKO96099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T778"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="5393" checksum="04DFE8C60226B9FC" modified="2017-04-12" version="1">MLVDGVDGADGVDGVDGVDGVDGVDGEDGEDGEDGEDGEDGVDAALINGSGETLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T792</accession>
    <name>A0A1Q5T792_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000699">
        <property type="protein sequence ID" value="OKO96101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T792"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T792"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="18720" checksum="82299F655FE4E176" modified="2017-04-12" version="1" fragment="single">IDTYQGPPDYVVHDTGKNFTSTEFKQLALSMSIKVKEVPVEAHNSVGKVERYHTLLRRAYEILRDKLKDKNIDKEIILQMAVKAVNDSAGPDRIIPTLLVFRAYPRITEIDPPSPSVIKRAKAIRAATKEVRRLHTERQVNNALAIRNGPSTIATLNLPLQSDIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8P7</accession>
    <name>A0A1Q5T8P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8P7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8P7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="441" mass="49018" checksum="096F6245B98A95E1" modified="2017-04-12" version="1">MALLVDKLRPRSLDALTYHPELSDRLRALAQSGDFPHLLVYGPSGAGKKTRIIATLKELYGSGVEKIKIDARVFQTTSNRKLEFNIVSSVYHLEITPADVGTYDRVVVQELLKEVAQTQQVDLSAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRTLLVRVAAPTENDICAALRIAAKREGWTEADGLNKRIAKESGRNLRRALLMFESIYAQNEKVTDSTPIPPPDWEALISITAAEIIKDRSPAQLLQVRARLYDLLTHCIPPTTILKTLTFMLVSQVDDVLKPDVIKWSAFYEHRIKLGSKVIFHLEAFVAKFMRIYERYESIREFTQPPEKQTGQLGGGQPHTKSEMKTTFDKNGNGNGNGANGEEYAQAQKLGMGQGAQGKNKENRNSDNPVDAGAARTRREQGYGPGSGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8Q0</accession>
    <name>A0A1Q5T8Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8Q0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="20244" checksum="0213F516696C06BD" modified="2017-04-12" version="1">MKEALTILEARGIEMMSQETTDAFFTVLLNLLEGSDGMSCQHVVEKWCQLALESKVFKGRFVSTNLGLQKSLATVCFDNNNVTLTRQILDQIVVKNDSKCDPGVQGLLFKLALHDEKDVYFLRWAKRGLGSTSVAFSTGELESVGLYSYTLAVHVFNMFHAEGIEEVLEFTKDVCLLITIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V1</accession>
    <name>A0A1Q5T8V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8V1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="73"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO96647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="422" mass="46582" checksum="ED00612BEB72A1A3" modified="2017-04-12" version="1">MGTTYVDKIEIRGSENAGVDIERTATTVTDQHGDYKEIPSESLTAGYHRSLTRRKVMMMTFGAGIGTGQALHYETNVIPLAAYITIFIIIIGLGNTFHVRIYGYIEYYMSFIKCLAVILLIFFMFIITSGGITATNGPIEFTYWTNPGAFKNGIKGIAKAFVQAAFSFGGGEHIAVIAGEVADPRQTIKKTVRPVFWRMFTFFVVNIWLVGLCVPSDDSDLPSASGTLGSPFVIAIKRAGVYKLAHVIKGFIFLSVISCGITSVYVASSSLTALADTKIIHPFFGRKDSQGRPYVSIIISLGLGGGLCYLNVNSVGVIVYGWFSSLVAIATLFEWSSCYISLLRFREGLEAQGKDLRTLPFRGFLTSWAQYLSLIIVVLIFGCEFYLPCWPFGGRGSVKIFSGYLAAPLFYFDYFAYKLYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAI9</accession>
    <name>A0A1Q5TAI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAI9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAI9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45229" checksum="55B2CF3D4C93FCDC" modified="2017-04-12" version="1">MARTSSRQAAQKAKEAISTTSETGGKVNAGAKRKAREQKAPEPKKEKREEKPEQPVQPEKDKKAEKPQELEQEIEKERPQQPEKETAAETEVDGIPKKSPKKEETEEAPSAAPAPTPQQGTNLEPSIESGIRKSEEREEKVPSNLLEKGIIYFFYRPRVNIEDPQGVEDVSRSFFVLRPTPLGAELDSGQGSVDKDARCRLMILPKKKFPTSGRERDMGFVEKANQSVKDLQEKFIAGSTYQTSTRGERHIEEARPYAEGVYAITSTRRASHLAYILTIPSEIGEIQENFGLYRRGSFIVQSKNPKFPGPSFARLPKDPEYPASVMEKFDDLRWVPLQPEFIEYPNAQFLMIGEAQDSLGKAASAQGGNQSHEIEPGEELEKMEHENEDRVHALEVLKDQGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAP1</accession>
    <name>A0A1Q5TAP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIRA-interacting protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAP1"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41583" checksum="B51C63369D43BAA8" modified="2017-04-12" version="1">MAPKYTLSDSESEAEAAVPSDKALDKALRKEVVTKYKAKNWEELTVKRVRRAVEESLGLEQGFFKNTGKWKEKSEEIIKDEFEILRTSAPDTVAESEANPTSSPPLAPSQNPTNKRYKAPSKQKPRKRQKTQTPVSDEEDELTELPDEGSEEEVVKPTKRAPKTTNTVKSKKPKEPSTEVMEISDNEEEETPTTEYTTEVTKDDSESEMSVVYDEEPKPKTVRKRKSGDGSSKKAAPKKEKKAAAKGKDEDLDPDQAEIKRLQGWLVKCGIRKMWWRELQPYETSKAKIKHLKQMLEDAGMTGRYSLEKARQIRDERELKADLEQIQQGAKKWGTGSGDESDGPAHPRRTARGRQALAFLESEGEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBL7</accession>
    <name>A0A1Q5TBL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBL7"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="36618" checksum="B8A614A9903C7F0C" modified="2017-04-12" version="1">MSKTDVTEVETTTALPPAKRSFGARLGAHFKKWWWVHLIIFIAVLLVILLPVIYVGYPRIAQNQVTDSTLNITSMVIADPTPDSFHLMQTQVIGSHSSYHPKIYSFLASVSLLGSAHAFTSVQVPEVQSKDGAEVNVDQIVDLSNADAFGDFAQAVMLNEDVELNIYGRPGLREGSLPKTTVTYNKTVSMKGLNKLTGFDVTEFHIMTEPKNGRNMNGTVYIPNPSVMTITMGNVTLDLSIGGTPMGYTYLDNLVLKPGNNTIPMFATVNQSAIIGLVTSSSNPYKDLNGLVPFVISGNSSVYNGKQLPYFTQALASNNLTVNLNVTRALAELGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBQ2</accession>
    <name>A0A1Q5TBQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor rrn3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBQ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBQ2"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="694" mass="77388" checksum="E36ED48FDA8DFF03" modified="2017-04-12" version="1">MVSVATIPQPPALTATPSLKPSSKMLPSSSPVSILKTSKSAGTKRKMADLDRSLSPVSSVSDTFDDAAPPAKKRARVTFNENIQTHSWNQNDPATQTGMSVAMVREEIRRAIHRHVSSGESEAYDQIKEIFTADPKKAGDTLYSYDLPTHPTLKNHLLGLLSHIASLDRGCSSLVHAVLESEWLGRDEPYVKLFIRFLGNLAAAQGTYLGVIFKMLVSKLAGVARGTGSLPGYAVVPVSEIYARVHMALRHIVRLIPSGSGTLSPVLSHTFPYEADPAKSYIAYTRNLIQIISYAPELQSDILALITEKLVKIDVQIQVDLEDFEDELGENLLHGVSNDPDEEVDDDDDDDASILSEDEADEDRRVAEIKDNIHKVDGMIDILFEFYNSSFTTGTLDDQRNSLDLIISHFQSIILPTYKSRHSQFLLFHFSQLHPDLLSKMTSCFSDLIFGKVQPGIIRQSAAAYLASFIARGAHIPSSLVRKTFNEMSAQLVEMHDKYDAACRGPDLRRYGSFYATAQAVLYIFCFRWRDLTTASIEGDSPQQVDELEPSQIAFPPNVKDTLSKVIYSRLNPLKICSSGIVNEFARIAHHFQLLYVYPLIEKNKRLRISAFRSIASSGLVQMEREIRAGDHLGYQLDAYFPFDPYQLPRSRRWLEGDYVEWRGIPGLDQDDEDSDSGAEDGDEDEDGTATDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCE1</accession>
    <name>A0A1Q5TCE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-galactosidase BoGH2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCE1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCE1"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048229">
        <property type="entry name" value="GalB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041463">
        <property type="entry name" value="GalB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012592444" evidence="5">
        <location>
            <begin position="19"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="10">
        <location>
            <begin position="126"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="6">
        <location>
            <begin position="228"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="7">
        <location>
            <begin position="352"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="8">
        <location>
            <begin position="677"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="9">
        <location>
            <begin position="750"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO97903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="904" mass="96808" checksum="59928A024AD337DB" modified="2017-04-12" version="1">MVILLPILFLASAGWATAATTSGRNRSSLNAGWKFSRFSSNPDSLSYSTLSPWMLPLANDFIVNGAKHQAPSGTPPGSNVQYIQASFNDASWQSVDLPHDWAIAGPFNAPGISGGMGRLPTNGVGWYRRNLVATADDVDGTKSIFLDVDGAMSYAAVWLNGNLLGGWPYGYASWRLDLTPYLQAGNNILAVRLDNAEDNSRWYPGAGIYRNLWLVKVDKTHVAQWGTYITTPSVSSSSATVNLVVQVENNGNVTRQVDVSTNVYTIDQSTGTAGTAVVASFQTTTVSVNAGAKQSVSGSVTISNPRLWGPPPAQTPNLYVAVTTLSAGGTVIDTYETKFGIRSLTYDRNIGLLVNGQHVYVQGTCNHHDQGSIGTAINIRALQRQLQTLQEMGSNALRTSHNPPAPELLDLADSMGFMVLDEAFDCWSQGKTSNDYHLLYSDWHEPDLRAFVRRDRNHPSVVAWSIGNEIPEQSTSQGGSEGQELHDIVKSEDPTRQSTSAMNSAGPTAPLANVIDIEGLNYQGEYGAYGSFHSTFPNKMIWGTETASCISSRGTYIFPVTSSNGQTYYNSGGSDSSHMWVSAYELENPGWGGSPDQVFAAQDNFPFVAGEFTWTGFDYIGEPTPYSGNPGARSSYFGIVDLAGFKKDRFYIYQARWRPDFAMVHILPHWTWPERVGQTTPVHVFSSADQVELFVNGVSAGRQNRLGKSVYRFRWDNVTYSPGDLRAVAYKNGNQWAMDTRKTAGNAAALSVTVDRASITGDGLDLAYVSVAVVDSAGTVVPRANNVVTFSVSGPGTLVSTDNGDPTDTTPFPSASRNAFSGLVLAIVKANVGARGQIIVSATANGIIGGQVFITASGSATTSTTTSSGTRTSTTTSSSTTTSTTTTPGTGNVSYSPSICLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCL4</accession>
    <name>A0A1Q5TCL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General amino-acid permease GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCL4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF37">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="295" mass="32469" checksum="47F78F4367867AF4" modified="2017-04-12" version="1">MAGEAESPRFSMAHATKLVPARVNFIYITSVIFVTILVPSNDPRLLGASAVAASPFIIAVEDAGIPGIGSLLNAGMMFGVLAIAAESVYLSSRVLRTMAHQKLIPERLAGVDDKGRPRLALIITSVVAVMLAYIQLSAGGLTVLNWLVSITSASFFTNWIIISITNWRFHLALKAQNDPLFNEVYAWKSSLWPLAPAWLMLISLLLLVCCIYAGAQPTGGAPFSANNFFQYTIGLILIIVATAGYKIVFRTPWRDTKTADCISGRRTLSSDELAMLDKYYNQPAWRRFFTYLQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCU9</accession>
    <name>A0A1Q5TCU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fatty acid methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCU9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCU9"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF1">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45335" checksum="8043169D82CC8FF9" modified="2017-04-12" version="1">MGPTHGLPRTGLAALLASLDIPGEIQLPAGNVVKVGNGEPKYRVIFQSKSALRTPMTELSVGRAYVSGEIQVEGDLGALFDFREKLKDKMPLRQKFQFLYDYFRTATAMNSKAIGEHYSRGDDFYLTFIDKRYRFYSQGLFKHPDESIEEASEHKLESMFNSLDLKPGQRLLDIGGGWGGVTQYCGARRVHVTTLTLTVDSARFIQRLISEKDLPGEVFLQDFLNFKPEEQFDHVVIYGVIEHLPDYREFARRVWDVLKPGGRIYLDGSAAATKFDVSSWTRNYIWRGTHTFMTVQDVMAEFLYHGFEVIEVARETKDYELTMLEWAKRLDSAKNEVIAGWGEETYRMFRLFLCGGTHAFKTNALQAYHLVAEKTRSPGLRPSTYRRIIQFLGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCW5</accession>
    <name>A0A1Q5TCW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCW5"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="225" mass="24556" checksum="F3AED6CE919D99CF" modified="2017-04-12" version="1">MALTVELVKLALPRRVPFHFISSASVTRFVCTDSFGESSVASFPPPTIPQDDYTTAKWVCEVYLERVSQSLGIPVWIHRPSSVTGSNAPKLELMSNVLRYCQSTRKIPDSEAWSAVFDFIPVESAAAQIIEVVHESGATSVENKGTRFVYESGEIQVEQNEVQTMMEADAGQKFETVPLAEWVNAAEAAGISPLLGVYLSQAADSQILLPRLVKGSGQGAVYEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE16</accession>
    <name>A0A1Q5TE16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 14.8 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE16"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="123" mass="14598" checksum="EC16985B22BA1D94" modified="2017-04-12" version="1">MTINPTYLAQRTRSSVNLTDAKNRVLKSYREWLRASPEIQTMYSLNMPVSAIRTKIRQEFEKHRYVSQLSVIDVLLFQSHAEFQETLNYWKQLSHVMKYFRPEEDPGARLPRNFVSGFLEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF20</accession>
    <name>A0A1Q5TF20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tricarboxylate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_8746</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="48"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24403" checksum="F95AE59B28D3EDC0" modified="2017-04-12" version="1">MAAQISVQPSASKIAPQTPRKGTAGKAAVRFLSYDTIRNVLSDENGKLSAGGGLLAGMAAGAVESVLAVTPTERIKTALIDDAKTNRQFKSGLHAATVLVKRHGPSELYRGLVSTTIKQSATSAVRMGTYNILKEMTKKQGIASNVFTSFGTGALAGIVTVYATQPFDTIKTRAQSVQGAGIVEAVKSVMQDYGIKGFWKGSSMRLGRLFLSGGIVFSVYEQVSALLAPATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFD8</accession>
    <name>A0A1Q5TFD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFD8"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="458" mass="50443" checksum="E5256E479B4DA7BA" modified="2017-04-12" version="1">MSARPQNIGIKAIEVYFPTQCVDQAELEQYDGVSAGKYTIGLGQTKMSFCDDREDIYSMALTTLSSLMKKYNIDPKSIGRLEVGTETLLDKSKSVKSVLMQLFTPSGNTNIEGIDTVNACYGGTNAVFNSINWLESSAWDGRNAIVVCGDIALYAKGAARPTGGAGCVAMLIGPDAPIVFDAGLRGSYLTHAYDFYKPDLTSEYPVVDGQHSLRCYTEAVDACYKAYHAREKVLKANQNGTNGVSDESQTALDHFDYILYHAPTCKLVQKSYGRMLYNDFLANPSHPAFAEVAPELRDLDYTASLTDKAVEKTFMALTKKRFAERVQPGLQVATLCGNMYTATVYAGLASLLSHVTFSPSEPKRIALFSYGSGLASSMFSAKIVGDVSEMVEKLDLKNRLESRTVLAPQAYDDMCQLREHAHLKKNFKPTGGVETIQKGTYYLTEVDDMFRRQYAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFU7</accession>
    <name>A0A1Q5TFU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8476</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFU7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="146"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="148"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="203"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="338"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="566" mass="60179" checksum="641FA011174A73DD" modified="2017-04-12" version="1">MPPKKKNADPAPAAKPKAPAAKTTTKPAAKAASKPGRPKKTDTEPAPKSTKATVKKVTKKVTKESAPAASAGASKTKAQPTKREPAKKTTAKASTTMSTTASKKRKAEEAEEEKPRAPKKPRVIREPKPKIVKPKVVINEVPTTRLNVFVCGEGSSGELGLGAAKNAIDVKRPRLNKFLDAQEVGVVQIAVGGMHCLALTHDNKIFTWGVNDQGALGRDTTWDGGYKEIKENAGSDSDSEDEDDSGLNPRESTPTAIPSSEFPEETVFVAVAAADSASFALTDDGQVYGWGTFRSNDGILGFDPEHRVQTTPVLIPALKKIKQLACGANHVLALNDRGSVFSWGSGQQNQLGRRIVERNKLHGLQPREFGLRKNIVHVGSGSYHSFAVHANGTVYAWGLNSFGATGIKDNAGDDEAAIPHPIPVESLSNQDITQLCGGAHHSIARTKDGKCLVWGRVDGHQSGLKVDSLPEDSLIKDTRGRPRILIEPTQVPGINAVAVAAASDHSLAIDADGRAWSWGFSATYQTGQGTQDDIEVATKIDNTATRDRKLNWAGAGGQFSVFTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG28</accession>
    <name>A0A1Q5TG28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like protein arp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG28"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG28"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000036">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="466" mass="52245" checksum="77ADCA5431CD5CBA" modified="2017-04-12" version="1">MVTKSRTSTKAAKNSPDVPARHIPNKTFVIDNGAYTMKAGYACDPSSSPEEALSNCISIPNAIVKTRDNRIWTGTQIASHVTDWNEAVFRRPVEKGYIVNWEAEREIWDQTFFEEKATARNKQLRIAHPEETTLVLTEAPNNLPVLQRNTDEMVMEEWGFGGYVRCLGPTLNAWNEVQSLFGDPLNKTDSDIMPKDCLLVVDSGYSHTTVTPVYKGQPIQRAIRRLDVGGKLLTNYLKEIVSMRQYNMVDETYIMNEVKEAVCFVSNDFKSDMERTWKANRKREEAQSVVVDYVLPDPNAHKTGFMRPHDPLLHAKKKKGALSGLSAEVLSEDVLVLGNERFTVPELLFTPSDIGMQQAGIPDMILQSLSVLPPGLHAAFLANVLVVGGNSCIPGFMERLENDLRGIASSECVVRVRRAEDPFRFTWLGGSRLASNREELGKLAITRQEYQEYGSGWAGRRFAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH04</accession>
    <name>A0A1Q5TH04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH04"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="396" mass="42872" checksum="EECDF31C4F3FAE66" modified="2017-04-12" version="1">MESKELKEKQIHTEGLIGQIQLKGLNLQAEGARQMTNLQTISASWVICDSWAGVAGTIALAISQGGPITLIYGPILMLFLVGACALTLAELASVYPTAGGQYHWTSILAPKSINRSLSYCCGMTNVFSWIAICTGIAIIPAQLIVGIALFYNPSYTPQPGWSSGGVAFLTGLVTPNYMYAGIDGALHLAEDVPIYEMWYEATRSQTAATVFVVLLCCAAVFALIGAQQTASRLTWSLARDRAIIGSQWLSEIHPVLEVPVWSLLFNFVVMFIIGCIYLGSSSAFNAFIGSGLVLQHISYAFPAALLMYRKRSEEWLPASRSFRLPNLAGWTVNVITIGFALLVLVFYDLPTVLPVTGSNMNYTSAVLGVMAIFGGLNWVIHARKKYDGPRLGHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THA7</accession>
    <name>A0A1Q5THA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inositol phosphorylceramide synthase catalytic subunit aur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THA7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="6">
        <location>
            <begin position="207"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="428" mass="48640" checksum="59AD3A7273628779" modified="2017-04-12" version="1">MNTFPSWKDRTQNQFGKLQIQMPWRSFQMLVPHRMRRKIRSKLRSRISPTSSISTLQTSFSPVDTLRSLQSHRWTMYDFQYLLLLILGFFSLTIIQSPGPLGKTSIATLLLFSLLLPITRQFFLPFLPVAGWLIFFYACHDWRPAIWVRVLPAMENILYGANISNILSAHQNVVLDVLAWIPYGLCHYGAPFVVSLILFIFGPPGTTPLFARTLGYISMFAVTIQLVFPCSPPWYENLYGLAPADYSMQGNPAGLARIDKLLGIDLYTSGFKQSPVVFGAFPSLHAADSTLAALFMSHVFPRLKPLWVTYTLWMWWATMYLSHHYAVDLVCGGLLATVAFYFAKTRFLPRIQSDKMFRWDYDYVEIGDASREFGYDLASLDGDFTLDSDEWTVGSSSSVSSGSLSPVDDHYTWESETLTSNHDLEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI46</accession>
    <name>A0A1Q5TI46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein 18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8111</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI46"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="9">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="619"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="10">
        <location>
            <begin position="856"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO99894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="962" mass="107549" checksum="2B1F4F19A037698B" modified="2017-04-12" version="1">MALDGSSSYVAPNNLTEPSDSLPIFDVQRVQLQFPIAADFVAAQVANNVLILALSTGRILRIDLDTPEDIDDIDLPKKSSEIGLIRRMFLDPSASHLIITTTLGENYYLHTQSRQPKALSRLKGVSIESVAWNPSLPTASTREILLGTTDGNVYETYIEPSTEFYRREEKYVTAIYKVPDASPVTGICAELVPSRPDQRRVLVATHGKLVHVLGRTGTTTKGRDGGGSIYADLFQRETALIHDISNPSGAAPSVLVVSSSSSAGGHQADGLTEKEFAWLSAEGIYHGQLSSETPFDHASMLPRTKFPASQSARGGKKMIQDPISAMTLTHWHVLALVEGRVVAVNRLNEEIVYDQAVLEPRQSSLGLLTDLTQNTYWLFTSKEIFEVVANDEDRDVWKVFLKEKKFDEALQYAHGHAQRDAVLTASGDFLAEKGNFLEAAKVWGKSSKGFEEVCLTMVDNKEYDALRKYLLSQLSTYKKASVMQRIMVASWLVELFMSKLNSLDDSIATNAELTEGATEGQVQDQLGDMRAEFQEFITRHKADLDKKTVYDIISSHGREQELLFFATATNDYNYVLSYWIQREKWSEALNVLQRQSEPDIFYKYSSVLMTHAATGLIEILMRQTNLDPERLIPALLNYNKTASVSLNQNQAVRYLNFIIVNHPKPSAAVHNTLISIHASSSSTSEAGLLTYLQSQPSTPPPYDADFALRLCIQHKRVQSCIHIYSAMGQYLQAVELALEHDDIELAAIVADRPEGNDKLRKKLWLLVAEKKIRQRGTGIKDAIEFLRRCELLHIEDLIPFFPDFVVIDDFKDEICTALEIYSRHIDDLRQEMDNSAQTARQIRSEIAGLDTRYAIVEPGEKCWICSLPLLSRQFFVFPCQHAFHSDCLGKEVLEGAGGKRKYIRDLQAQVSSGDISSARREEIVKELDGLVAEACILCGDHAIKQIDKPFIAASETTDEWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI55</accession>
    <name>A0A1Q5TI55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyceraldehyde 3-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI55"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI55"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF2">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28703" checksum="20980C8DC25B1E32" modified="2017-04-12" version="1">MPTDKSEFDLQAALSSKAWFGFDLDDTLHEFRFASGQASLSVFEVISAKYGKDVDDTKAKYQEILRQSTAHAFTDGRTSSEYRRERFSRLLQAHGIEKYEDIDHILKIYQSSLRSNLTLKAGALQLLQALQRLNKKVMVITEGPADAQEWTIRELGLGPYVDILVTTNEVGRSKVDGLFAAVLERYSIHPEEIVYFGDNEVRDVHTAQKEGILAILYDQKQENHLRSPDALRINSWDKLQNMLLGVKYIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJJ1</accession>
    <name>A0A1Q5TJJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJJ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="42351" checksum="DF6F0CE5BFB8ECE6" modified="2017-04-12" version="1">MKRSWSPDRQEEQLEAKTHPARRRTAPLVSSLNASVSPPPSRRKSIPNPEAHELASIEAGEVKVTDHLGIFSTKLSQHTRPLSISQSTPRLTIDDYVDLYRRNSHPTGRHFVIHQHDHPIAGLHYDLRLQFSETSSVSWSIMYGLPGDPNSEKLNRNATETRIHCLWRKIRLRLHGTRLPAGYTLLLRMDKSTDYARPARKVPKRRRRNLQSTTAPPPPPSTSSSSRSPSPPPRDGTQKQEPTDNQLPTKDSRSEADHANHSDDDIDYQIRKNNAYPGSSNTIGSIHQRRWYLSMDRESSGFEPRRVSTGDGRSKRVWVRSSDGSELSGFEPFYVRGPEIERSVVTGRRGQDVLEDEGVEGFIARKGWRAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJK7</accession>
    <name>A0A1Q5TJK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="32432" checksum="EE57CD043AF1FD27" modified="2017-04-12" version="1">MVNIMKKFRRKRRLSSELDTRWGDPSISYPNEGSWNQWDQPSGFVANATMGSPRNIQTQETRQVVPLESTPSQNPGASSDSGYQSFNTREDHAQSASTIPKGYFNENIRHRADKIQRAPVKGLGIDGTAHEMGSTNGHTPPDDSCDEDDDDDDDDDDEERDTLGDPSGGLIFRNPLTGDPLRYSPREDQDPYFDRASKSPPLSVTQRMRRFSGQSSSTEPSSSIAGTASSRRTSYTAASSVSAPSLPPDTPRFAFTISHPAHEKRSAPRPRHREPEPQARQEMVPSYDELYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM63</accession>
    <name>A0A1Q5TM63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM63"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="28915" checksum="BA4B179BA98AC2A8" modified="2017-04-12" version="1">MTSSVQGLPALPEVGIVPPSSPLALKAFEYAKQHCTETVYSHAIRSGYWATIIAKKLPEFRDNTNLSLEMVFVSCILHDMGWANTPELLSTDKRFEVDGANIARDFLLNEKQHTDDGNLNQATIQRIWDSIALHTTASIARYAAPEVALTHLGITADFFGPNFPGPDGKPLISPEEYRAVMSIFPRAGFNTEGFKKIMCGLCRTKPATTYDNFVSVIGRKYGLDGNGDGREEYTKAWEESQTQLDSFLVLGLDALEAAHDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM95</accession>
    <name>A0A1Q5TM95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM95"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF31">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP01351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="312" mass="35081" checksum="501B44B37699121F" modified="2017-04-12" version="1">MSTNTSDGGIDFALYRYTPSIPAAVVFAAIFLIVTILHGIQLWRYRTYFFVPFIIGLLFECAGYIARIFSHFDTKALGPYIVQTMLILVAPPLFAASIYMTLGRVIVALNCHQYSVVPVRFLTKIFVVGDVISFLLQCGGMCRFYDALFIDTNFVPGGGYMAAGSLSAMNIGANIVIGGLAIQLLFFGFFVIVSAVFHWRVKRNSRNISHCLEHSKKWEPIMWALYAACFLILVRSIFRVAEFVEGNDGFIMRREYLLYIFDACLMALSGIVLVVIYPGSFLGRNGNKRDSELQLMSTDEGYRPQRSKDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMD1</accession>
    <name>A0A1Q5TMD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="7">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_7376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMD1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012140645" description="AA9 family lytic polysaccharide monooxygenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="12">
        <location>
            <begin position="21"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="11">
        <location>
            <begin position="422"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="747"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP01386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="789" mass="86003" checksum="43F1EF4216D7D128" modified="2017-04-12" version="1">MKHFASLLGIAAVLAQSASAHYIFSKLVLNNEASKDWQYIRETTRQTIYMPTKFTKTFDNLTPNDADFRCNLGSFSNAAKTEVATVAAGDTIGMKLFYDTSIAHPGPGQVWMSKAPTGNVKEYEGDGEWFKIWEKTLCNENADLTTNAWCTWGMSQFDFQIPKDTPPGEYLVRAEHMGLHGAQANEAEFFYSCAQVKVTGSGTGSPKTTYKIPGLYNDNMTLFNGLNLWVDKAKDVEADIAQTPIGDEPWTGGNSGSSSASSSSASSSSASSSSASSSSSVASSTFSASSASSTPAYDWDTRPRPPPSIAMTHSQPLPVSDTGSPPLLPEITNNQPQIHILQPGSGSEPGSDPDQNHPDAPLPIIQPYRDDPDSDQRPDYLVQYEPRPIDDDEGEDEDAAAEMARPRKAWRARLRVFWLRNMGMFLVLLAQMFGASMNVMTQILEIHSSMHPFQVLFARMSITAVASYFYMWYAKVPAPFGTRPVRKLLLLRATFGFLGVYGLYYSVQYLPLSEATVITFLAPILTCYACSLLIPGETFSRRQQLAALVSLAGVVLIARPFSKRDGAGTGTGDNAGTTAEDESPEDADAFHHVLATIVAFVGVLGAAGAYTTIRMIGRRAHPLVSVTYFSSVTTVISLVAMLTAPWVPFRLPSTAMEWTLLTGLGVCGFLLQFLLTTGLSYVPPASVRVPGAKASQGSKATNMVYMQMLFALFYDKVVWGSTLSPVSLAGSVLILACAIYVAVAQEERKEEKKPKAEVEEEENAEDEDDRRFKDRDDEETEGVAARERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRL4</accession>
    <name>A0A1Q5TRL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_6934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRL4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000920">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="822"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP02862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1209" mass="134658" checksum="C4A08A857295D808" modified="2017-04-12" version="1">MEDRIQFDINESLKYYLSDPGSIPTPDADPELLDCESDPNQLSTALVDNVLNPIVDAIAENPEGLTRSSFFESLQFLLKYTTFLPSKSLSKVLDLIVSGLSVEADIIHGDLESDEQDAIQHHKQLLEMYGFLLQWALSAVEVKAAEKPAESAPARRGGPKSRSKSAKDGQWDWTPQIQISMETMCKVMKLKLGRIFMTTSDRDTFINLFTRTIYLILESEQRVKSMAIRMHAFKVLCIAVKHHGHAFGAQTSIVQSLTYFEHLSEPMAEFLHILAEQYDYPQLSDEILKELGNKEFNSNDTRGPKSVSAFIIKLSELAPRLIIKQMTLLAKQLDSEAYTLRCAVIEVCGNLISDLSRQEEPSENSKTQINAFFDVLEERFLDINPYCRCRAIQVLMRICDLEQKFPKRRQAAAQLAARSLEDKSSNVRRNAIKLLSKLVATHPFSVMHGGQLSHKEWTDRLDGVDAELNSLRPAETPGFDGDVTTVDPELLDDATQLPDDSPSKAPRMTEEEKAEAMQKAAEQAATSELLTRLQLTRKYYNEAIRFIEVLHSASAIVSQLLSSRNKSEVIEAMDFFVMLDAYKVETARSGIRRMLRLIWTKGNSDEGKGVQTHLIDCYKGLFFDAPDSFSSNDAANYIARNMISLTFGATPAELTCLEQLLSTMMKAGHVSEAVIAKLWQVYSVQRKEISKTQRRGSIIVLGMLALADPDVVVKEIEAMLRIGLGGLGRSDLVLAKYTCIALRRMVPGRQAKSKDVVTVPKLANDHSVLIKLAAILEIVSESKEWYGVAEQAISAIYALSKHPDVLCSDILRRKTRFVFQPHLERPSSSHTTASGEEQRPGTASSEEQNAKPKPSSAALSQLLYVVGHIAIKQIVHLELCELDFKRRKAEQEKTKTAEATASKEGEAAEADELDLIGGTTEDDFQDAMAHIRERELLYGENSLLAKFGPLVAEICANNNSYPDRDLQASATLCMAKLMCVSAEYCEKNLPLLITIMERSEDPIVRSNAVIALGDMAVCFNHLIDENTDFLYRRLNDDEASVKRTCLMTLTFLILAGQVKVKGQLGEMAKCLEDDDKKIADLARMFFTELATKDNAVYNHFVDMFSLLSAERNLEEASLRRIVKFLIGFVEKEKHARQLSDKLAARLPRCETERQWNDVAYALSLLPHKNEEITKVVTAGFNKVVSGSTSAPASAPASTPASTAPVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRR4</accession>
    <name>A0A1Q5TRR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRR4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP02900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="573" mass="63648" checksum="02B54FD84442FA39" modified="2017-04-12" version="1">MLERRLRTLGDQTRQDGSSAHTTGFFRATDLHSACSSVALAKSYLPPKPIAEFLANAFMKYSQTNYFYFDEATFREKLDFYYSTTDPPSINDAGWICTLLMIFAIGTQFAHMQSNSTPGGVTSAIESTPDDQIGLELYRFACRLIPDLITVASVETVQAFLLMGVYTLPIDTAGLAYVYFGLAIKMAIQNGMHRKLPEGNLAPEIAEVRNRLWWSAYSLERRIGILHGRPMSISPTEIDAPMPFDLPALRPKDKMTNLPNFIAAIVLTDHLAKAAEAMSSLRTCPKARKKHFLRHLAATRDRLSSWWDSLATEIYCRDLAATGPLFRCNVHLEIYYNTTLIYMGRPFIISQVSSGLLDSADGATPHEVPDIVNILRRDSLHAALRVVEICQLLQDTVGLARVSYTEFNGCRVALLALIAHSVNGPSSSISKTLNQGMALIRQICTGLESAQSEIAVIEALEQARQRLHNHSVAEQSGSTESATGYNQFREWTKLWRGDPLEGGGADALNGLDMSFEQRSPNTVPSFDGFFSSFPNELSEFTAIPGLDFSMSLGQEWLHEPQPEDSEWLMNPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXK2</accession>
    <name>A0A1Q5TXK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXK2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP04967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="10897" checksum="DF173A92A8AEC23F" modified="2017-04-12" version="1">MRGRTRRFAVAARRTRPAVVTDHASLQYLQTTTAYSKRLARWVDEFQEYDLKIQYRKGSDGVAPDTLSRRPVSLEMALPTYPNPGRFGTLLLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXM9</accession>
    <name>A0A1Q5TXM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXM9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXM9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="6">
        <location>
            <begin position="79"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="6">
        <location>
            <begin position="210"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP04981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="50985" checksum="F939B5138F64C9C6" modified="2017-04-12" version="1">MADTLNITAVSSSFDLVKAGTLTRLHPGQSAIVQIGVKNKAGVAAGTSCSGVVTATWGTAYGPPITSTETVSGSCGFGDYTADANSLSLHRSPDWFNEAKFGIFIHWGLYSAPAYGSVAPNEDYAEWYWKRMNDPTFKTQTYQYHNATYGKNFTYDDFISNFTATNFNAESWVNLIAAAGAQYMVPVTRPPTNPYTGAVETYTGFVNVSDFIQDIQLPQQNVLAYNYDTEIMWCDIAGSANNATIFASKWINWARDQGRQVTFNSRCGIAGDFDTPEYRTNGGTVPRKWETNRGMDPFSFGYNYRTPDSRYLTGKDIVQTLVDTVSKNGNFLLDIGPKNDGSIPAIMQQGLQDAGKWIHAHAESIFKTRYWSVTPGLNNWRYTTTQNAFYIHYLTTPSGTITTPDIIPYLPGDTVTILGGSMDGTAVPVTWNSDGTLSLSVSSALQASDKFVWTFKLAYTSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXN6</accession>
    <name>A0A1Q5TXN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP04998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11684" checksum="AFBA99763F6B3107" modified="2017-04-12" version="1">MGPYGRRFQPAQGRVELLLDERTPWPVKRTRWMVDRVQEEQPWQRLFGRLFGFVNEFKEKLAVLVHITSGQPPRGHELLSIRHRYSAAGEHRNMFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U049</accession>
    <name>A0A1Q5U049_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glucose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U049"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U049"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067142" evidence="8">
        <location>
            <begin position="29"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP05864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="156" mass="16585" checksum="CC966CF233028D9E" modified="2017-04-12" version="1">MSRTSTLYAEFKMIRFLYFLSTLSVAAAAPAGSSPALTYDYVIVGGGTSGLVIAKHLSENSNVPVLVIEVGGSVLDNTNVTSMNGYGRAFGTDIDWQYKSVPQTCGGNSTQVLRAGKALASTSVINGMSFTRAEHVQIDAWQTIGNNGLTWNALWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B0</accession>
    <name>A0A1Q5U0B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="10210" checksum="FD8B5A85080BC001" modified="2017-04-12" version="1">MTPPFADEYRYLDITSSRVVATLGEKGIKYGFCGGYAAGFIVSQRVTKDIDVIASKDPTEAFLAPVAVEEILSAHKDLEGRWELVNREVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0F3</accession>
    <name>A0A1Q5U0F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0F3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0F3"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010005359" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="174"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="420"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP05956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="495" mass="53994" checksum="0351D0E34616F223" modified="2017-04-12" version="1">MVGSVSFVKALPFLAASAVASVNYPTIPSDLTTPFQQRLAVYGPNSVSVGWNTYEKLNQSCVVYGTSATSLTSRSCSTTSSTYATSRTWSNYAVLTGLTPATTYYYKIVSGNSSVEQFLSPRTPGDKTAFSMDVVIDLGVYGKDGYTTSKRDTAPVVEPELNHTTIGALARTVDDYEIVIHPGDFAYADDWYLKFANIFDGKEAYQAILEQFYDQLAPVAGRKLYMASPGNHEADCSEIPYLLDLCPEGQKNFTDFMHRFENTMPKPFSSSSKNTTAQSLAAQARSLANPPFWYSFEYGMAHIVMINTETDFPNAPDGTSGSAKLNSGPFGKANQQTDFLKADLASVDRTVTPWVIVAGHRPWYSTGTSNGCSSCQTAFEQIFYQYGVDLGVFGHVHNSQRFAPVYNGTADANGMKDPKAPMYIVAGGAGNIEGVDAPGTEPSYTEFAYGADYSYATIRFVDEHNLQVDFYQSSTGTLLDSSTLYKSHASQFVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1R6</accession>
    <name>A0A1Q5U1R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1R6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1R6"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="95"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="228" mass="24415" checksum="F1C73761C1FF2D14" modified="2017-04-12" version="1">MGKDKVEKKEKRAEKKEKRAEKDGIHKSKKDKKEKKDKTALADAVEKEITSQLSEGLEAAAGVADVEVDAMAIDRPVGAVVPFANPLVEDKQAKKVLKSVKKAAVNKSLKRGVKEVVKALRKSPVPAANAKIDIPSGVVILAADISPMDVISHIPVLCEDHGIPYVFVTSRAELGASAATKRPTSVVMVTPKSGKNKKLDEGADGEDFGKVFEELAKLAEKECKAANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1W8</accession>
    <name>A0A1Q5U1W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1W8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1W8"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP06475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="33547" checksum="9F2E1B1C9B9EC5FE" modified="2017-04-12" version="1">MHKSTERGAQGPQSQFEPGHEVPVQHLEKPGLQSELGDPKPTSTQLPTEDNGYQTYKAAGKLIDKRAIITGGDSGIGRAIAILFAMEGATSLITYLPEEETDAQETKRRVEELGQKIHLLAVDLRDKKNCQKVVDTALQTMGGIDTLVNNHGYQNMVENIQDLDDDQWERTFDTNIHPFFYLSKYALPHMKKGSTIINCASVNAYIGRPDLLDYTSTKGAIVAFTRGLSNQQVKNGIRVNCVCPGPIWTPLIPATMNTSAQEQFSGSPMGRPGQPSEVATCFVFLASQDSSFISGQSLHPNGGVVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1X3</accession>
    <name>A0A1Q5U1X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1X3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1X3"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18610">
        <property type="entry name" value="GH130_BT3780-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106:SF5">
        <property type="entry name" value="GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="334" mass="37036" checksum="1662BD70571F76B4" modified="2017-04-12" version="1">MPASRQNEVNYTAPYFPLLGFEQYAGNPIMRPDASHPWESAYLYNPSAIVMDDMVFLLYRAQDAQKTSSIGLAWSSDGYSFTRYSQPIIAPTEPYETPGGCEDPRVVRVDGTFYLTYTAYDGKVARLCLATSTDLVNWKKYGPILPDFIETVYNWREPVTYFSSNAPGWTKSGAIIDERQPDGYYYMQFGDTYLYTANSTDLIHWEVSGDGKPFAPLMNVWEQALTESGPPPIKTRDGKWLKIYNGMATGGVGGYAVGQYSTGQMLIDPANSPLGPPIARLETPILQPTTATEITGQVDNVVFSEGLVQFKGKWLLYFGAGDAFLSVAQTPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U392</accession>
    <name>A0A1Q5U392_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U392"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U392"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP06948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="56972" checksum="F0989CEB992C96E7" modified="2017-04-12" version="1">MDSGHKHQSSLDDTTKSGAVGSIDEPNKLQGYASAPGVVDDVTRVVDHKAERRLCRRFDIRLLPILAIMYLFNALDKGNLGNAKTDHMTEDLHFKPNQYNLLLSIFFVPFVVFAPPFSMLGKKFSPARVLPVLMFSFGSFTLLSAAAKNFSGLFALRWFLGMSEAAFFPLVIYYLTTFYRRGELARRLAIFYAASNIANAFSGLIAFGVFQIKGSSLPNWRYLFIIEGGVTVIFAVFAFFYLPKSAAEASFLSEEEKALAFHRIQVDSSAVVNEKFRFREAIGIFKHPTTYAFLCIEICLGVPLQGVALFMPQIVARLGYPTVKTNLYTVAPNVTGAVMLLVLAFCSDYTRLRSPFIVLGFLFTFTGFMIYASIDDVHKQIQVAYFATFMMTWGTSAPSVMLSTWYNNNIAHEGRRVLLTSIGVPLANLMGLVSSNVFLEKDAPKYMPALITVSAFGATGACLAGLLGLYMWWDNKRRDRRDGRVIRARDIPTERMRDGPASPEFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4R3</accession>
    <name>A0A1Q5U4R3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4R3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4R3"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="637" mass="70320" checksum="493458873A1724A3" modified="2017-04-12" version="1">MARYAQFDFYQQSPSTLDVPPSEEDEMSVLDDKILDSTSPGLSDPRRPSYDTDPTAFSHRNSVWSNYSHASSDQSQSRPSHLPHSVLDSTSGQFMAVDGPQPYAPPQASWALSRTASGSCTPTAYDQYPSEAEQTATSGPFSGGAVGPVGAIPMGAVSYRGAVNFAAPPGTGGVAMSPQSSQGWMPAPMDLSDAAAVKSNCYRNGSPLTLRRDGIRKKNARFEIPAERTLSNIDQLISQSTNEEEVKELKQQKRLLRNRQAALDSRQRKKLHTEKLEEEKKHYTHTISQLEDIVSSLQKREAELMREKNEWIAQQQQITTYLESMHMEKDEMIRSHTLETAELRKKNNILLETVEKLERGGKPTMADQAQAHAHIQTADFTGFENLSMDTGPWDEFGMANGLPMDTVSASHVHTQSQAQAHPQSQPLQVTERAADKPASDYPFSWNAFYMCLLFGAFIASNANTSLAGRSLPQLSEEYRAESANVLKAVLASSPPDLTHPSAIAVSASAPQPSITMDMTQMGASHARSSTLDELHDTLVLPSEEQERAQVFSLNVDQYNSLTTFEDDGAPFKAQPSNLQAALAAMRSNAAQHRVHGGEDVYSRSLMWERVPEKVIRDFRRMVQEFGGSPVKEEMMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4U8</accession>
    <name>A0A1Q5U4U8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4U8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP07495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="535" mass="59876" checksum="5C89C7218FEB498A" modified="2017-04-12" version="1">MSPFLMSLYAAEILSICGVLFYVIYQCFFSPLAKYPGPFWAKLTKLYRAYLSLRGHAHRDFIALHKKYGNVVRVAPNELSIADPEAFREIYKAGNKFHKAAAYNVVQGTRSFDLVGQRNEKIHSEQRKLVARAYSMDSMVHLEPKVDLVISQMVEQLDKISGHTFDLGIWLQLYAFDIIGAISFSKPFGYLEAADDHGLFLRIQKSMSSIAWLMHAGWIFRLNQKITPIFGNWLAAADRNGHFFQLAAQEISARKKRGGDSKDILGQLFKTQKAKPQLTDQDIAFMMTSNVFGGSDTTATSLCAAFLMLLKNPDAYNRLMDEFKEKKAQGNLNDPITFEEAEACEYLQAVMYESMRLHPPFGMIMDRDVPAGGMHIGKDFIPEGACNCPPLLPTPDILSNNYLPANAGTIGAFIYAFFYVLLEPVAGGLLAPLVIGFAACGNYLLGTYGMGVNYWAGGIHIVSWLAQFVGHGKFEGRAPALLDNLVQAVLLAPLFVWMEILFFFGYRPELKARMEKGVEVEIAKFRKEQKVKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9T5</accession>
    <name>A0A1Q5U9T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9T5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9T5"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="492" mass="53644" checksum="9564B0E94EAD920C" modified="2017-04-12" version="1">MVAESSSAPTATLQRVDSQPENPYAALIEDQSIAIIPSFTLESGVTLYNVPVAYTTRGVLSPKGDNVLVICHALSGSADVADWWGPLLGGPGQAFDVSRFFVVCLNSLGSPYGSASAVTYKDGKPENGYYGPEFPLTTVRDDVNIHKLVLDDLGVKQIAAVVGGSMGGMLTLEYSFFGKDYVRAIVPIATSARHSAWCISWGEAQRQSIYSDPKYDDGYYAFNDPPATGLGAARMSALLTYRSRNSFESRFGRNVPDPSKRQNINGTDKLPTPPNEHWAIHNDGHRGGVTSRSESRQGSPVPLADVQYMDPQFSGTKTFSAPTPTKPDGRPRPPTYFSAQSYLRYQGEKFVKRFDANCYIAMTRKLDTHDVSRHRASPDSENPVLEALSKVEQPALVLGIESDGLFTFAEQQEVAAGIPDSRLERIDSPEGHDAFLLQFEQVNRHIVAFFHEVLPDIMSQSNVDGAAAVASVKKLTKSSTFGEAEVEDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9W3</accession>
    <name>A0A1Q5U9W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9W3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9W3"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="364" mass="40791" checksum="F39F231E57A18156" modified="2017-04-12" version="1">MGGPSTTAEVEDFLGRLFADADLIPLGRFQTYLGPLIARRRTPKIQKQYAEIGGGSPIRKWSEYQCEEMCKLLDKMSPETAPHKPYVAFRYAAPLTETMYNQMLADGFGNGKGGRAVAFTQYPQYSCSTTGSSLNELWKWRNRLEGKRADNEVEPAGTIEWSVIDRWPTHSGLVEAFAQNIEAQLKTYPEEKRKEVVLLFSAHSLPMDVVNRGDPYPAEVAATVHAVMQRLKFSNPYRLCWQSQVGPKAWLGAQTQDTVMEYVKRGQTDLILVPIAFTSDHIETLYELDLEVMHEANSPGVKRAESLNGNPVFIQALADIAHAHLKKGEPCSAQMTLRCQGCKSERCLESKKFFAGKQHGSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAX7</accession>
    <name>A0A1Q5UAX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAX7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP09619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="281" mass="30898" checksum="8E1FD5A95D4288E1" modified="2017-04-12" version="1">MSYKPTETLPLPNSTVRIPRLGFGVYRSPASQCVKSVLKALEVGYRHIDTAQFYGNEGEVGEALRTSGLPRDQVFVTTKILSPAGSAEQTYDKLLASVEKIGGPGGYVDLFLIHSSSSGPAGRKQLWQALEKLHGEGKAKAIGVSNYGVQHIEEMKAYAQVWPPQVNQIELHPWCQQRTIDAYCKQHGIIVEAYSPIVRNYKANDPTLVEIAEKYKHSTQQVLIRYALQKGWVPLPKTDNPDRIASNADVFGFDISAEDMDILDSLDQGDAGAIVEAVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB43</accession>
    <name>A0A1Q5UB43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8032 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB43"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB43"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="177"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="544"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="643" mass="71364" checksum="DF410931B388070E" modified="2017-04-12" version="1">MATTAQMQRPAYPPIYHTPQSNSPASVASQPHDQHGRNMYTQSPQMPHQMYGYAPYSPMNPVQPSPYAAHPSPQSHTLTSQSMMMPPQTTTAQMSPHQQSHASNALSSSPIMKMDPNSQSASAQRPMLNPPLPSPGNNSLQAGNVHQTSPLGTSSSAAPGPIPATTPLVVRQDSNGVQWIAFEYSRDRVKMEYTIRCDVESVNVDSLSQDFKTENCVYPRACCNKDQYRGNRLVYETECNTVGWALAELNPSLRGKRGLIQRAVDSWRNSNQDPRLRSRRVRRQAKVNYRKQAMAPPTPHMSATGPVGPSLPSTPTMSMPQGPRHSLSGPPMSMGPPQLHHHHAQPDGSPKIEDGTTDYTSATQRPAQLASDIRAAQVFHDATTIPTSSSIGPSMPPLLRDTSLSALGRHHTIATSSHMDYTSAETTDGNISPSNEDLFGQLPDGKRRTFILIEDPQRGARVRVKVMLDKVNMDEIPDSYRMSNAVYPRTYFPVQMKDAPGTSVPNKRFFRDDTEHGDGSDATVSRTSVLAPSLDGEREIDVPQLSRRRHHKEVMLNDLGYRLSWCQSRVFAGRTLFLQRSLDAYRNKMRSSMLAAGQDASEIPEHFDTRRGKRRFLERGEHRLKVETGEPSASRRSVEEVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBD3</accession>
    <name>A0A1Q5UBD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000448">
        <property type="protein sequence ID" value="OKP09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBD3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="419" mass="46994" checksum="0940B6023B0B932A" modified="2017-04-12" version="1">MAGRAETRTPEPPDHDERENSPPRLARPRRTTRPPNNYAREQEIDNGQRTTRSQLRKKTQDKPTAQRDAVTSDDSATESEDLNTATLVKELIKLRREIRRRDELHKEELQKVKEEFSAALAEVRHELQTLTDRPLTPQSHSEICAQNNHDEVLREIQSLRDAISPSVPTGSPSYADVARTPPTSHPSNIRTLSSWNTTPTTFTDTLYCTIDTSKIADSDNERISAGPIRTAVETEIRTMENHTHWRCRAVTVDPKNINRIRIACRDEAEHQLVKKVAEAKIGAGARVLRDELYPIKVDSVNRAAVLDENDKIRTGAIAALSEENETTVAKIAWLSKKESAKAYGSMVVYLTKGSDTRRLLADGFFHARGESGVTSEIGHKAFQCKNAQKCAKYTTEGHRHSNYDSSIFKCVPCGGPHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBV6</accession>
    <name>A0A1Q5UBV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000423">
        <property type="protein sequence ID" value="OKP09968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBV6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBV6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="164" mass="18955" checksum="5C9214DCAC2B6B11" modified="2017-04-12" version="1">MAAYNTVIDGEFRRLKQMRDNQVSEEIMDFLEKAHWDLKFRGISNPSGPFNRSLIHYAAMGDCKELLLQLLVIRTPINPRDGDKRTPLSWATQYGSYVTARILVENGADINALDNMYLTPLSRLLQQDKAETNHYQALKLYLEKNGATRKGRKRAWIMRRIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCQ7</accession>
    <name>A0A1Q5UCQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000375">
        <property type="protein sequence ID" value="OKP10250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCQ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11480" checksum="AC58B40C69DE147F" modified="2017-04-12" version="1">MFYVNVADILKQRRHDTKRASGYYRRRGLADTDPLVENEAQAKESHLFISTVIAGPREETPADGDIIWLWSGWALLFTKLYELDWEDRDWQAAGFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE42</accession>
    <name>A0A1Q5UE42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE42"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="32544" checksum="03E87C4A25F084C9" modified="2017-04-12" version="1">MGKRKQDLGDVPMGGTGQAGDSDSDDDVDMVNVDFEWFDPQPAVDFHGLKNLLRQLFDNDAQMFDLSALADLILSQPTLGSTVKVDGNESDPYAFLSVLNLQEHKDKPVIQDLINYFKAKAAANPALSPLNQLLSQTPIPPIGLILTERMINMPSEVIPPMYNMLLEEIAWAIEDKEPYNFSHYLIVSKNYEEIESKLDMEESRPQKKKKKGGEPSQRFFFHPEDDVLERNAMCTGTIEYTNKQDDGHADSKRAFQELGIRTKGSLTLIDGANFENTVKALTEYLKPPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEY1</accession>
    <name>A0A1Q5UEY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEY1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="8726" checksum="14E4ACE00ACBA3F8" modified="2017-04-12" version="1">MDDTPTVEVSGTPKPDPQNTANNASNEVEMGGTQETPNPQSKPTEKSEQTATATEDIILIDAQNEPEPPTPAKKSGGFKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF23</accession>
    <name>A0A1Q5UF23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-reducing end alpha-L-arabinofuranosidase BoGH43A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000307">
        <property type="protein sequence ID" value="OKP11074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF23"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="328"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="515" mass="57278" checksum="68E678450F8C9CD9" modified="2017-04-12" version="1">MSDTVNPIISGFAPDPSVVLVGDWFYLVNSSFHAFPGLPIYASQDLVSWKQIGNAIHRQSQLSLAKSQANLYPVDDGKFLVGSGGLYAPTIRHHQGTFYVVCTNVIRAEGKNRDATENFIVSTDDIWSGTWSDPVYFEFEGIDPSLLFDDDGKVYLQGSGGIGPGTTINLFEIDLKTGAKLSEEKIIWNGTGDIYPEGPHLYKVKGWYYLLIAEGGTHGGHMVTMARSQNVFGPYESCPSNPVLTARGTKEYVHYTGHCELFQDKEGQWWGTCLGGRLEDQGRCPMGRETFLTRVDWDGEWPVFDQVKLSPRNLSATRSSSHLTAEGGLDYLYIRDAIMSNYRIENNYSSLTLTASSVGLSHPTDSPTFIGKRQRKLSGSSSVVLEGIEESWSSAKIQAGLACYKEEHRYSRIYYDAAQKAVVLELVNAGQKIVRTEKHTLEEVPRSLRFRIEYTEKQYSLLYSVQPHVENDWTSLGTVDTLEMTDPDFTGPIIGVYAVGQTEGVQVQFEGLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFF2</accession>
    <name>A0A1Q5UFF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lovastatin diketide synthase LovF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_3214</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UFF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="1067"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2613"/>
            <end position="2694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1099"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2694" mass="294583" checksum="1D60EC5AB55358F6" modified="2017-04-12" version="1">MTPYLNGDTDNHTERVAQNGIGDREPMAIIGLAMRAADEATDAESFWHFLLRARQATRPIPEDRFSSKAFYHPDSDHGGTFYAKGACFLGESPNGFDAAFFKMSKTEVQSLDPQQRILMENVYHALENAGLPMEDVISSNTSVFVNGFNYHHADRLNSDLELSFKHKPTGAESSMISGRVSWFYNLQGASLTVDTACSSSLVALHLARQSLLAKESEMAIVSGVSVIGYPAHLMKMSHSGLLGPGGKSMAFDSRADGYGLGEGVGTIILKPLSAAIRDGDTIRALVRGTGLGHDGHTPGITYPSATAQESLIRKTYLAAGLDPKDTVYSESHGTGTQAGDLIECTAIAAAFETQQRESPFYVGAVKPNLGHLEGGSGIASVIKSVLILESGVIPPNATLEKINPKISPAWNLQFPTSCIPWPTSGVRRSSISSYGISGTNAHCILDDAYHYLRQRRIAARHRTRETVPSNEEIQSLVAKISEHYKTDTKEPNSEAPAPNTNGVSINGANVVKSVNGVKGLNGTNGTNGVKDVKSSNSVNGINGTNGINGTNAFNGVNGSNGVNGAKSNHPAPNKICLQVPESPIIFILSAFDQKRLEKVVAHTKDYVTSRILDFESSPKQALNDLAYSLSEKRSRLPWKSFALCSSVHELQDKLPKLPSKAIKSRSALRIGFVFTGQGAQYAKMGQQLLVYPLFRQSLEAAGAYFKSLGSDWSLLEELNREAKDSKISKSAFAHPLSCAVQIALLDLLLSWGVVPHRVVGHSSGEIAAAYCAGKISREAAWKVAYFRGHVLRPGESKPPFTGGMIAVGLDEEPSRHLLKKVHARFSGGSLSIACYNSPHNHTISGDLDMVDALKEMLDEQGVFNRKLKVEHAAHSAHMEYFSAEYDELLGELPSKHRLNFDHTVQMFSTLTGRLLDDSCAPGKASHWRDSMVCPVKFTDALSSMCFDPVPTDGSSTHNTWVDVILEVGPHPAMQSAAKEIVGSNADIPYLATLNRKDDGLNSLLETIGNLVVRGAPINLNKVNRATNPSLAPKMMVDLPPYPFNHEEQALYETRLIKNTRLREFPRHDLFGAPVADWNPNSPRWRHFLRVAENPWLKEHLIGDNYVFPGAGYVVMAVEAMQQVTDDSDMIGVHLRDILFKAMLVVPDDTQGVEVCLSFYPVPESKTSLSTTWRRFEVASYNQETEEWIEHCTGEISPNFKKSLNPIDGSRQEKTAQAEWLAFVQARESSCQAPVDLAPIYKHLKDIGINHGDSFQGLSNVTVSDGNQGLMTGDIIVQNIKQLMPKQYAHQHLIHPTTLDNAFQAVFAAIYDLNGKQMLRRGCIPSSVREMWLSTTDLSSEPGTTLRCTSQASPSLHGSFESAIQAWNPSNPSAKAFSLTGARLAPFKSESSDASTDDRRTCYSIEWHPDLALITNNDLQQLLPKSTDTPASYASQLEWLSKLQLASTLLANDGLLAIRGAKASSLGDQYTTYLKLLRSIAADLTVDAIPYVPLETWLKYSSNATLKKQLYREVEARNPEGALLIKMASRFSSILRKETTIQKLLSETDDLVWDSEKSNLSRGNILPTLTQFLTLLRSSRRSVRILDVQNHTGALSEQVLKILCGDNDADFVNQYVIGYPSADGSEALRKRLAAWGDVVSYKTLDLGADLLEQGFEPKFFDIIIIDNCICRIPNIESTFSRLNSLAKPGGRLCILQEMRPESLHTNVSLGFLPTFFQEIEGSLKTNSISRKADWDKALRNTGFSGIDFEASTSTYAEFADFNLMVSTAKHTHEEAVVPSLEVLVILQSHSKISRLLTGKLIDAGVKFSICQLGMLRPEDLAGRTSISLLEAEEPILNSLDSTTFQAVQQLITGSDSLLWVTGDPLTEPKFQMAIGLLRTIRWELDRNNLNLVTLSLDGEATGTPEGNVDAIFRVFEHQYLRHGVDPGGSNAEYRVRRRVIETNHIVKDKIASTVIRNQFERPKAILQQWDAIERPVRLVSPQPGVDSLTWTTDEDLYGQPLTPHEIEIDVRAVGLNFKDLLVAMGEIDQPGFGHEAAGIVVAVGSSVSNLKVGDRVMCLGDPSPGRMGTLRTRARLHSGLAIKIPETLSFEIAAGLPIIYGTVIYSLGHVARLRAGEKILIHAAAGGIGQAAIQYARVKGAEIFVTLSSIEKKRFIMDSFDIPEDHIFSSRDLTFSRGIKQIAPEGVDVVLNSLSGEALRQSWTCIAPFGRFVEIGKLDFQSGSKLDMTPFLNNITFSGVDLNALAEQRPEICQELLQEAMQLWSSEKIHEARPTLVSDYGQLKEGMRLLQTGKSIGKMTLVPGSHPVSVLPERLTPLELDPNASYILAGGLGGIGRSIALKLASLGAKHLVFLSRSATVHEAGRNTIAKLEALGCTSHVFQCDISDDARLREVFASINETLPPVKGCIQCCFVLKDGAFDSMAHQDWETALAPKVSGSWNLHNLLPDVDFFLMLSSITGIVGNRSQANYNAGNNFQDALARHRVSKGMHGASVNLGAVVGVGFVAENSEYAGKHTFKMANQQTEEEVLAVVEYMIDQRHHTALSSDSAQLVCGLRNPTSYSLGNEAQPSHLQYPMFSQLPPAPQGSSGAIGAEAGKSAPLIRDQLQAATTQTDAAQIIHESLRHKMANLLNVSEDSFDDSLSVRENGVDSLIEMEFRTWFAKELGATVPLKDLAKDLKQLSSKLVLLSSFSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFX1</accession>
    <name>A0A1Q5UFX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_3137</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000285">
        <property type="protein sequence ID" value="OKP11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFX1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFX1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF43">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="186"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="461" mass="51847" checksum="AE540CBDD509FA9F" modified="2017-04-12" version="1">MFRIALTPGKPDSGITFGPMPIHEHWLCLAKAGFTTVEAVPPAPALPDEAWFFQGNQYARIKIVPKTQQDTISWGLRSKRSGALARFGLDRIQVVLKTGTGEPEKSRAHLSTVTSCITNLIVFSDHDEKIGRHHFIDILENLPPTYAFNNPDFAAYRAQKLAHSQGGSVGYSQEGWRLDRFKFLPMVEKTYEMRPHADWYVFIEADTYYFWDTLFRILDQLDPSRMHYIGSPVPGSNGRYFAYGGAGFVLSTGVMNRFIRDSSIDSRVSVQYQDWAKKDCCGDAVLGYAILDKTGVKLEGLYPTFAGDELGTLKVDRERWCIPLLALHRMSPEQMTALWEWERTRPYNEVFVVLSAEDVSTANAVSNLFFTRPYSHIPILISAMSRPGHSGTTTPTLLNQKTPLPILLLQRAALPALRTQIACSFPILPESAGLGSRYRWENLCLTIKVPYLVGISKNCQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFY7</accession>
    <name>A0A1Q5UFY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dextranase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFY7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005192">
        <property type="entry name" value="Glyco_hydro_49_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03718">
        <property type="entry name" value="Glyco_hydro_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 49 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="94" mass="10083" checksum="319B14E534B1905B" modified="2017-04-12" version="1">MQITNVVCEGPCPGLFRLTPLQNYADFMLTGVRFLGVLIGGSVPIGDSIIATTEDTTYPGCENLTMGLKIKDWTVGGEKVTMENAETQGQRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG94</accession>
    <name>A0A1Q5UG94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="13" type="ORF">PENSUB_2965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG94"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="174"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="395"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="395"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="574" mass="64245" checksum="CDA4B97782E694DB" modified="2017-04-12" version="1">MANAPHGGVLKDLLARDAPRHDELAAEAETLPAIVLTERQLCDLELIMNGGFSPLEGFMNQADYDRVCQDCRLADGNVFSMPITLDVTQQIVDDNKLKAGARITLRDFRDDRNLAILTIDDIYRPDKKKEGELVFGGDEEHPAIVYLNQTIKELYVGGKVEAVNKLNHYDYVGLRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYEALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGKNSKGVDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPEGVKTLNISGTELRRRLRTGAHIPEWFSYPEVVKILRESNPPRNAQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTREDRHTNIQRIAFVASELTRAGAAVIAAPIAPYEHSRQYARDAVSQAGNFFLVHVATPLEHCEKTDKRGIYARARRGEIKGFTGVDDPYEAPENADLVVDCSKQSVRSIVHEIILVLESEGFFEKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGM5</accession>
    <name>A0A1Q5UGM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGM5"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="231" mass="26024" checksum="F5F44E25ACB14110" modified="2017-04-12" version="1">MAHLLKPIKIYGGSFGPNPLKVSIILQELGLPIQEVPTQFCDLKKVGYQAINPNGRLPTIEDPNTGITLWESGAIIEYLIETYDKDQKLSFPHGSPEAHHARQFLHFQMSGQGPYFGQAVWFKRYHPERVQSAIDRYITEVRRVSGVLDRILAKRDWLVGGRLSYADLAFVSWQNTARNVLSEDGYDESEFPNLSVWLAKLNSRPVVKGLNEAQQAMMAEKLKEAAAAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGR8</accession>
    <name>A0A1Q5UGR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sphingosine N-acyltransferase lag1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGR8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGR8"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="126"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="451" mass="50978" checksum="47979EF3584C78CA" modified="2017-04-12" version="1">MAKETIAPPPPASELNVYVSSPSGPRPAKETTFREWVVTNQIGISLTILAMLLALHNLYPSLRPYTQPFFELSYHDPASNTYVQGWNDVYFVASATLALTAIRAIVIELVIQPMGRSLGLKRKAALRLAEQGWQVLYYGFIWSIGLYLWKNSYYWFDFGAIWNEWPARPLGGLMKWYILVELAFLLQQIFVIHVEEKRKDHYQMLSHHVITSTLLGSAYIYGFYNVSNVVLCLMDIVDVLLPSAKVLKYLKFQNACNVAFGIFMATWVVTRHVLYNMLWWSIYKNVPQQMAYGCYSGSSAKMISTNGYPDAFAYMFGPFRGLENPICMNRTIKWIFLSFLLSIQLLSIVWFSMIVRVAYRVVCSGAAEDTRSDEEDEVETDDTPATNGTVRLAAKEGATTAPIVVNENAPGLDRRRSNGSASVRARGRGRVPFDQSDRKALLGRIGCDKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH29</accession>
    <name>A0A1Q5UH29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyroglutamyl-peptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH29"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="32220" checksum="8BB8741AAA3B0983" modified="2017-04-12" version="1">MGDYGPVVPSTDSSPVGQPSQPPQGPNEISVLVTGFGPFKTNLVNASFLIASSLPPSFTFSHPTTDNTNDERRISLHVHPSPISVAYATVRETLPLIMEEYAATHDGRRPDLIIHIGIASPRPYYSVESLAHRDDYNITDIEGRNGYEDGEKRWREMGLPPVLVPGLATEDDIKNSNQSFSSGLTTTTTTTTTRVTVPYPPDDHFLHVWKSYTPEHLDLRVSQDPGHYLCDFIFYTSLSLAKRQGVDRNVLFLHVPGGSEDADVERGRKVALALIKTMVTCWIDEKRKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH89</accession>
    <name>A0A1Q5UH89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH89"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="574" mass="65465" checksum="7391D4D09B4A1F7F" modified="2017-04-12" version="1">MSGRNAPRSKNGCSTCRRRKVKCGEERPICMRCLNLNLTCEWGVPVKRGRSTQIRHLQPAPTSTPDQIIWPTSATSELGDAVALTPDALLNGLSPISWPGDSPLVEQPQSTSFFPPSAPAPFGTPLYPPLSVNEIACANSLTLTEHDQKYFQYFPSSSIIYYYMKGWHWSSFCYLYQGPAATNKVIMRMFLAMAASDMHRQGLVVRSPGRPTAEDHGRYHYSLAVKEFRQLLETPRRSVSVEELEIIFATMFLMVTYEWQFGHSVRHLQLHLHGVRSLLESHPQLFRLKDVNDVFLSPEAESPSSDDVAISKVSFIPEQFLLWILYIDASCRPMGLTESLYDYVVQSKNPALHPDHLHRCARLWGRCFWGEQYPDQEVLDDIENYRALELLHAGFCFRHRTWKVLVDSGGTSDTTESLYSEILSTRDKFSDLFITAKFAGTVSARRTLNTIYMAVCTFYAQVILHRRLLCVESLPASLHRQATAGIVDIARKQFASDPRLLQRLHWPLLMAVIETDDTSHRVWLRQRLFELRDSSHSEYIWANEVADQILAQQDLNPGCYANLAGLLLRRLHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHP8</accession>
    <name>A0A1Q5UHP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent 3-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHP8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHP8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="28675" checksum="87AC499C87D6D23C" modified="2017-04-12" version="1">MAKRLEGKTILVTGASSGIGKSTAKEFARTSPNNLKIIVTARRLEALNELAAEIKAEVGDGVKVLPVKLDVSNPEEIKNFVPSLPVEFKEIDVLVNNAGLVKGVAQAPDIAPEDMAVMFNTNVTGLINMTQAILPIFKKRDEGGRGDIINIGSIAGREPYAGGGIYCATKAAVRSFTDALRKELIATRIRVIEIDPGQVETEFSVVRFYGDKSKADAVYKGVEPLTGDDIAEVVVFAAGRRENVVIADTLVYPSHQVCPRSRVIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI74</accession>
    <name>A0A1Q5UI74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI74"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="711" mass="74686" checksum="717F24DF20F93718" modified="2017-04-12" version="1">MTVPQPLINLEGHCSVISGNTLYVYTPTGFVSIDLKVNGTWNPLPSGVSVSNPVCLKGGIEGSQNEDEALYVVGGTTTNSTSPYTGLQRFSFKDSKWETLGSGTTLMTDLTGHGAGFVASNSSIIIYAGTTGASTSTALSSQTYLISTVSPYVSTSVNNQGAPSLNNPQILHWNSTHVGMFSGNDGSGGNKAVWTYNLATGWESSPVSLPSAISTSTPLSLLSGSRDSKVLQYFDMNASPNSVTNLELITSDGTPESPAVAVGSSSKKRSTGSYPTYNDTLAPSYKWSDYGLAQGSNGLVVLSSGKSNDSLAIFNQTSNSWVNSTELFYGKSVQHVLTTNTTTSTTMTPTATPTPSTSTSATPSSTTTAAAAAAGGSGTDVKVIIGAVLGAVCGVGIILLLLLWLLKRERTKRERNGQSRGIDKDRLSFQDQGIEPLAGGAYPMAKSPVPVASMSADSLAIISGKYAGEKSLMPPSNSGYGLSATPRKSSPLSPIPSSGLAPSSMYSESAYRDSTTPSELGHKPGDRTTDEGWGKYFQDNNTTNLGGMPADRSTTSSIYTKSDYRGSAWPMSNLTPLNLGFLDQPKPLGRVYSGSPTTEHASSSRSLAIPEGQSARISSADSISVTSDDDPHDTNWTGAHTSWLGRPASSNYSFYNSSSRDLPSSNPQFPRHSKGRRSSVAIADDIDELPMPGRSTNVNSDMSWLNLQAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIB6</accession>
    <name>A0A1Q5UIB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIB6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="228" mass="25777" checksum="EB8FC006F2B87EFC" modified="2017-04-12" version="1">MTPNEKSEIIQSSTNPDSLMSKLRQLVELGHHFDPVRQALEVLRNLNRDEDHDEWDSYDWQDWREFNEKIRDRETDNTASDSELSRNVIQFLEHIQAAIKAMVARCVKFPVQGTFYGALSTLCKIGEMLATSSSSLVHVAVRKWFASNTVLEQAIFDITNAIELPQLVLIFEDMTNQDALGPRLRELETLGSKHNFFSGLGSFLDGVLNVMDGGAMVTVQVMAEREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIF8</accession>
    <name>A0A1Q5UIF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIF8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIF8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="59985" checksum="9F4B47AE52D282FE" modified="2017-04-12" version="1">MHSSIRPNQFAVIQLPSDQTRIVKLVPNTFAANQVIGRPFFLTFEILDAPQSDGYQLRVVPAEELHAEHLIEEAEADGEGEEGDSGAGTPMRTNRTIVDDASTQKLTTQEIEELKKEASGAGKDIVAKILESHANLDKKTAFSLAKYTLRKRKKYIRRFTVLPLDVSFLANYFLDQRDAQRTMELRDEHVGLLGCLGNVHHGGESTLDAIPTIKPNGRYFVVDETGGLVVAAMAERMGILYPENEDEELESTDGAQEENTEKKSTTSTPRRKRPRPMSASGNTITVIHAYSQPNLSLLKYFGYDINTPDESHPLHTHLKTMSWLQLVDPSADPILSNEPPALSAEELAELKASKRTAYYFKRNRWEKFRAVTDEARAGGFDGLIAATLLEPAGILKHAVPLLSGSAAVAIYSPTIEPLTELMDLYSTARRTAFINRKRDLEVQKAPGETVNLAPLFEEFPLDPTRLLPPTLHTTRVRVWQVLPGRTHPLMTGRGGAEGYLFHGVHVIPAEASIQAAGTFRKKRKVETTSTPVSDRDVEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIP2</accession>
    <name>A0A1Q5UIP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIP2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6443" checksum="E3C54D73177ECD9B" modified="2017-04-12" version="1">MYQTPPSLSAASLAESEWPNGIPQGQRGPAGCRLADEEFYKFIAITCNNPFNSIYNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJW1</accession>
    <name>A0A1Q5UJW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJW1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="471" mass="54123" checksum="3A463A989D6CAD8B" modified="2017-04-12" version="1">MAKEYGGMFSLKIGSNTLIILSDRRIIKEVLDKSSSVSSNRPNLSVAHTITGGDHLLFMDSGTEWRLFRRLLHQEFMSSRCDNLHIQTQNAEAVQMLRDFIIYPDQYMLHAKRFSNSIIMSLLFGMRTPTFDTPHMQKLYRLMDHWSKIMEIGSTPPVDVFPLLKFIPEQFLGNWKSRSLEVQREMVDLYGEIVRHVMHRWKTSGGRGCFMDNVLDQNGKLGLNDHQLYFLGGVALEGGSDTSSSVINTCMHALVQWPEIQKKAQREIDGFVDETRTPVWSDFAKLPYVTQVVKEAQRWRPVGGLGIPRVLTEDYWIDGKFLPKGATIMTNLWELHHDEKRYANPDVFDPDHYAGYTKLAPEYLTASDPVARDHYAYGNGRRVCPGIHLGERNIFLGICKLLWAFEFKKAVDENGNPIETDINPTTAYSEGFIISANNFPCQIIPRSEKRKETIMREFAELEHVFSKYETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK18</accession>
    <name>A0A1Q5UK18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK18"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK18"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="369" mass="40983" checksum="CD6A20AFA9106B02" modified="2017-04-12" version="1">MSQDPSTLLDQATILLQTGRTDEALPTAQQALDLATNNASVQLQAVNLLGEINVELGEIETAREYFLRAVEQDPNGSIPESEGGGAEKFMWLAQLSEQGGTDSVQWFEKGVSSLRQTLQSLQGKTGAEEVTLAEEKKVKLSNALCAVAEIYMTDLSWEEDAEARCEALITEALTFTPDAPEVLQTFASIRISQLKTEEAQEALKRSISLWKDLAPEDPKVPDFAVRISLARLLMEVTLEFDALEVLERLILEDDQSVEAWYLGGWCLYLLAEKQQAPKDLTEDEAAESPRHASLIASREWLKQSLKLYDLLEYEDEPLQAHALELIQGMVAEIGEDMEDSEAEGEGEGEDWDEEIEADSDDEDHEMADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK24</accession>
    <name>A0A1Q5UK24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK24"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK24"/>
    <dbReference type="ESTHER" id="9euro-a0a1q5uk24">
        <property type="family name" value="MpaH"/>
    </dbReference>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="106"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="444" mass="50307" checksum="7D58C108013D6829" modified="2017-04-12" version="1">MSSSPFRVVEHVVPCQHLREYPAATANEQEQPLHLAVKQYIPLDNPNPQPGDVTILAAHANGFPKELYEPLWEEIHARSQANGFRIRSIWMADVAQEGESSVINEDSLGNDPSWFDHPRDLLHLVNVKRAEMPRPIIGVGHSMGGAHLTQLSLMHPRLLHTLVLLDPVIQRQSTQLDIMSMRERRRLIAKTTQLSTHRRDLWPSRQAAAEGFKRSPFYQAWDPRVLDRWVKYGLRDLPTAIHPLDPNTVVDKKNPPVTLRTPLHQEVFTFSRPNYNHIPGSDKPVNRVTHPDLDADHPDSYPFYRPEPARIFSQLPHLRPSVLYIFAGKSDMCLPDMMADKLATTGTGLGGSGGVAKGRVRDVFLKDFGHLLAQEAVNECADAAACWLAPELRRWRDGEESFRAQWSKKSKIEKMTVDKQWMENVPAPARRPKNGEQRASGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK60</accession>
    <name>A0A1Q5UK60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_1596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK60"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="308"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="349"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="710"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="867" mass="94970" checksum="E0D48FC756BBF125" modified="2017-04-12" version="1">MEEDTGADSISRPALQLQATSFAGYTAPSLSPAFKLDEGYSDDTRSQPDKDLISDNVMSLPEWVLAQSEADRAEFAYSLLRSLSTATLAGVVDRLNPLLHMDPVVKLPPELTFQIFSYLDPRTLLTASLASRSWRSRILDSGLWRVLYIQEGWRVDTRAIFNFEQEHAEAMSPQTRRSRPRYSEPDLGEPKHKKRVPPSWYDTRGAEGQGPSNGKVEPDHEGDHHMADANDRGSHTSMEKAGIASPSLAHNSIAFLQPPLKSSLLTRTPNGSLRVNWVHLYKQRRRLEANWHHGRFTNFQLPHPSYPEDAHQECVYAIQFQGKWLVSGSRDKSIRVWDLETKRLWHRPLIGHQKSVLCLQFDPSPEEDVIISGSSDRSVILWKFSTGRKIHQITNAHADSVLNLKFDHRFLVTCSKDRTVKVWNRHDLMPNDEDYPRICKGGGASYPSYIIDLNDIAPNMLEASIVNGHIKSLKAYSLLMTVEGHGAAVNAMQLHGDEIVTASGDRMIKVWNIRNGTCLKTLIGHEKGIACVQFDSRRIISGSNDNTVRIYDHISGAEVACLKGHNNLVRTVQAGFGDPPGADEALRMEAMEVETAFWKARQEGAPVHLGPSALRRAGHYSNTAGSRDPRDIRALGAKIPPGGGGSPWGRIVSGSYDESILIWHKDRDGAWAIDHRLRQADAAANAARGNLSDAARAAIQAQVRQLQATQAAAAAPAPQQPAAAQNTADQDTVEDTPNPPATNNNPPVPPAPQDGGATAGPSNTTTATTAGTTSNPHPQPAQPVQAPAPAPAPAHPPAAVVAAAAAAAGHQFHPHRNRVPIPTSRVFKVQFDSRKIVCASVDPRIVGWDFACGDEEILEACQFFRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL02</accession>
    <name>A0A1Q5UL02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL02"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="16511" checksum="2FBABB3448240D08" modified="2017-04-12" version="1">MSSFTQPMPVVACGRIPAMGKSISQHLLPEYEVIHFILSYEAADAELPHLLAGHDPQSRSPNEIGTHDYSRLPRAVIFGRGYEPQQVEELKKKFAGVAKEPVAWVRGNPAQLPAGTAGPDYAQNVAADMKKVLNKWRDEGEKDEEILVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULT1</accession>
    <name>A0A1Q5ULT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin alpha re-exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULT1"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="958" mass="108337" checksum="E34A413A3551ADE2" modified="2017-04-12" version="1">MAEALGALLEASLDPHRNKEAEAALRQEEQKPGFSLQLLQISASDSSPSNIRLASALCFKNFVKRNWTNEDGHWKLPQNEVETIKRELINLMISVPPSIQSQLGEAVSAIADSDFWERWDTLVDDLVSKLDPSNPTVNIGVLQVAHSIFKRWRPLYQSNELYLEINHVLGKFGTPFLALFEGLDTYLEQNKSNKENLTQGYNQLTLMIKLFYDLSCHDLPPMFEDNIGAIAQILLKYLTYDNQLLHTDDETEAGSLEYVRAGIFEGLTLYVQKYLDAFGPHVGQFIQSSWSFLTTIGQETKYDILVSRALHFLTSVASMPEHAGSFQAEETLGQIIEKVILPNVSLRESDEELFEDEPIEFIRRDLEGSDSETRRRAATDFLRRLAEKFEESVTKVTLKYTEHYLAEYAKDPASNWKSKDTATYLFSAIAAKGVATSTHGVTATNNLVSITDFFQQHLAADLISDDGVHPILKVDAIKYLYNFRSIITKEQWQQVLPVLVKHLASENYVVYTYAAIAVERALFLSDAQGQPVIPPTEITPLSKELLEHIFQLIQRDPAPEKVQENEFLMRCVMRVLVVIRDGVVPFTDVVLNRLINITDIIRTNPSNPKFYYYHFEAMGAFIRFSAPANPSKLEQALYTPFAGILQNDVQEFMPYVFQLFAALLEANPSATLPTYYQELIAPILMPVMWESRGNIPALVRLLSSIIPRGSQYIIEHNQVEPILGIFQKLLSTKANEGYGFDLLESVVATFPPAALEPYFIQIMQIILQRLQNSKTENLSLRFVRFYHFLTAHDDKGYNPDTIQQICEKIQPDLFKGVYIGLVLADTQKLARPLDRKTAVISLTKTIANSEAFAITYVKGWALTCNTLLKLLELPPEVVRKDDLIEIDAEEMSFGVGFTALNTIRMQPKDPWPETGGDLKAWVGSYLKEADKKHGGRVSQFAQQRLDDQAKAVLGSYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMS9</accession>
    <name>A0A1Q5UMS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_553</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMS9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMS9"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF5">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="318"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="57638" checksum="944201E9C366F8F6" modified="2017-04-12" version="1">MSAPPLQERKPVKDLEKVFHYTDTMTRKPTRENDPYEYQAGFGNRHLSEVIPGTLPAGQNNPQEPRFGLYTEGITYSAFAAPRHANFSTYMYRVRPAAAHNGYKANIPHKSDIENCFLTLNPKVATLAEQGEWAPFPLPKDDEKIDFVDGLHTLGGSGDPNLREGIALYVFMVNADMDRRAFCNTDGDFLIVAQLGKLDVQTELGKLFLQPGEICVIPRGIRFAVRLDPGHSVARGYITEIWGSSWVLPDLGPLGGHGLANPRDFLHPVACIDEELHADWSIVNKANGLYHAIEQDHSPFDVVAWHGNVVPYKYDLTKFSSQNSTSIDHTDPSVNCVLTAPSRDPVTPLADFLWFGPRWDVASNTFRLPYFHRNAATEFLASLYGNGLGRSDDFLPGGGSVEISHTPHGNFSEAYVYEMRNQVNEPRRILENQMTIMIESSRSFLFTEYARTGCGTFKNQGTDPKVWDALPDKFSAYPNIQEILKQVKADNEARKQRLQAYYDDDQLAQLVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN18</accession>
    <name>A0A1Q5UN18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN18"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN18"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39315" checksum="181F7129143AC1F2" modified="2017-04-12" version="1">MGVHAIYFYQYIVRCQAKLDISVILDSAVTLCAAAAAVFLWLSEKEKSLGSLDLIAGYLACSLFRGILLEQSDRNSLEIEADYLLKSRALLEAIWLVQIFLGRKIYSYHDVESSSTAEEAAGLLGQAFLYWILPVLREGYSAALKLQDLPRLDDQFSSGTLRQKAAENWHATSHIYTRWRLLYALVKCLKGPFLAPILPRLFLIMFTYLQPIFIGVAIRYVNGKSQTILGDINGVKLVLFAIIVYAGMAASAAIYQTRINKLRVMIRGALVGLVHHQSLRLPLQASRDSSALALVVSDIENVESSGETCHEIWARLMEVLIGTALLASCIRWFALLPSLLIFGLYSPGVKPNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNA0</accession>
    <name>A0A1Q5UNA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethyl-sulfide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="3">
        <location>
            <begin position="28"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="53299" checksum="96F0E520F3C2604F" modified="2017-04-12" version="1">MGDTSSSQGQIGSANGSGKKQILINAFDMSTNPKDKSATKRKLEYWIELAKLLERGGINALFLADTTGGYDTYEGKLDECIRRAAQWPVTDPTIPISAMAAVTKNLAFGITSSTSFEQPFLLAKRFSTLDHLTNGRIGWNIVTSYKKAAFKAIGIDTPIEHDQRYAQADEYLRVLYKLWNGCWAPDALSPDPETDSYVNPDKVREINHQGKFYSLSTRHIVDPSPQRTPFLFQAGTSPAGSAFASTHAEAIFVSSHSPEVLRPKVQKIRELAAANGRDPQSIKFFGTFTPIVGRTDEEAWEKYEELKKYASVVGGLVLFSGWTGIDISKIPLDQEITEADSHEANKVTSLLDSLLKTSKDVPKWTPRVVAEKAAIGGLGPVAIGSPTTVADEMERWIREADLDGFNIGYVTTPGSFEDLIDLVIPELRKRGLYPDLPSESDEPLTAREKVYGKGQKELRDDHEGSRYNYDVYQEEEPYKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNE9</accession>
    <name>A0A1Q5UNE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNE9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="259" mass="28299" checksum="73B439659AAD6AFF" modified="2017-04-12" version="1">MLSNTSSDFDLTIRQQPDRARVAGGKEKDEFPQAIPPRSPDRQPVQIPPAATGFTGYPTTATASRDYNQYYGAPPVKRHRTSIDYGRQSIYDQESRMAARPMDPYSQPTAMYSQQPAYQTPGMQPYQTSQVVPDYGMSYGLHPSAAPMSQMTDPSGQTRPSQQQAAVGQLMAMNQPGTPVRHPKNSTGAMMAQGYPRSGYQTPENSTILPPLQRSYNQVTNGAAARGYFDQPPPTATSILPSQMAPEGNRYGSGNDTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQW1</accession>
    <name>A0A1Q5UQW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQW1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="196" mass="21850" checksum="B6F761D5DC96183E" modified="2017-04-12" version="1">MANERYFGRACKTCRRRGRGCDRRMPSCNTCETSGQTCEGYQLQWPGLASRGQLVGKAIPVAETKRRRTRRVQRSTVPSPPSPTLPQSPSSPANNDKDQTELQPERFEDLLDPIQLFADIADLGTPSNLLWSNNVPLINNLADDTVEPQLDPESESPSQDPEPFVGSLGLNHILGPSLDILGIPDELKFIMQYRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URB3</accession>
    <name>A0A1Q5URB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit sconC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongin-C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3411</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URB3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URB3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="10">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP15016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11345" checksum="900C1A9F2F880BCE" modified="2017-04-12" version="1">MADPTTSEFVTLVSCDGFEFIIPRSAACISGTIRRMLDPASKFSEALSGRCVLENLTGIVLEKVCEYFMYNEKHKDQANVPDMEIPAELCLELLMAADYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URP5</accession>
    <name>A0A1Q5URP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URP5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8271" checksum="468A4271A283DA2F" modified="2017-04-12" version="1">MGGPTLNPESPLTVGAMGSRGTGLAWLSNSGIVKLNLMLVLFQVSSYATGYDGSMMNGLQSLTTWKNFFDNPGASELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URT0</accession>
    <name>A0A1Q5URT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5URT0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="735"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1768"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2334"/>
            <end position="2407"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3404"/>
            <end position="3481"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3970"/>
            <end position="4043"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4521"/>
            <end position="4594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="4499"/>
            <end position="4519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="5085" mass="561212" checksum="D1CE13B2AFE5A0A3" modified="2017-04-12" version="1">[encoded data, 5085 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMH1</accession>
    <name>A0A1Q5SMH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair protein RAD16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMH1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMH1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="350"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="691"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="772"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="944" mass="106683" checksum="21CF4D72DE41043D" modified="2017-04-12" version="1">MRRRSQAAVIPDSEEDVVSGTSLRNSSSSRRQAPPRKPSHSSRVIQDSEDDGLASLDSDPPNISTSRNGSTMAVKVVIPTKKDASPSDSSGSSGIRSTDGTTGCSTPATSVGTPAESSIKRTRGRVNASDRAQSLRTSIMTRRASLRGQRGTKRSADDAALSEDELSLETSDAAIAHALQMEEYEQPAPKKQKTAASKRSRQRAPAVPEIMDLSSDSELSEWDLIEKSLSSEEDLYSSAGSFYETGPRGQSEEQGQDDDDDDDSYDWDAGDRRRREENQADLPPSWDEQRKARRMLADRKKLEKKHPAIITMWDTLKATPIITPKAAPQPESITRKLKPFQLEGLNWMMEQEKTQYRGGLLGDEMGMGKTIQAVSLIMSDFPQREPTLVLVPPVALMQWVSEIKEYTNGKLKVCVYHNSDSKVKKLSRADLRKYNVIMISYSSLESIHRKQEKGWTRGNGTVKEDSVIHSIDYHRLILDEAHSIKQRTTGVAKACFALKASYKWCLSGTPVQNRIGEFFSLLRFLQVKPFACYFCKQCPCEQLQWSANKQGRCTECGHTGFNHISLFNKEILNPITEGRSMTERKEGLAKLRLITDHIMLRRMKEEHTSSLELPPKRITIHNEFFGEIEHDFSRSIMTNTSRQFDTYVSRGVMLNNYANIFGLIMQMRQVANHPDLILKKHVQPGFNVLVCRVCDEPAEDAIRSRCRHEFCRKCAKDYIQSFDDTSAVDCPQCHIPLSIDLEQPTIEQTGEGVKKNSIINRIMMDKWTSSTKIETLLYELYQQRSKSHTPKSIIFSQFTSMLQLVEWRLRHAGFNTVMLDGTMTPAQRQKSIEHFMKNADVEVFLVSLKAGGVALNLTEASRVFIVDPWWNPAAEWQSADRSHRIGQQRPCVITRLTIEDSVESRIVQLQEKKANLIRGTINKDQGKALEKLTPEDMQFLFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMI2</accession>
    <name>A0A1Q5SMI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">High osmolarity signaling protein SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Osmosensor SHO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_13843</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMI2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMI2"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 19" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="403"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="192"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="709"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="822"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1054"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="866"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1118"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKO89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1130" mass="122318" checksum="2BD607D69A2AF3A2" modified="2017-04-12" version="1">MGFLGVYTAVYDYQPQGEGELEIKEGDLLYVLDKNSDDDWWKAKKKAERDDEDEPEGLVPNNYVEEAQPVHQAKALFDYTRQTDEEVSFSEDSEILVYDTSDPDWTLVGVGAEYGFAPANYIEIVGDATPTAGTTAVPPSPPSAAEPAPPSLPTRPTQPAPEEYEETPSPSPIDTLQNPAAAAIANIIHQQHAPPSAQPEPTRDEPSPPRLPTRPSHEQEEVREESPPPALPRRPPSEQFTPPMPQYDPDPSPPPPRPSQPAPPMGGNSRHYVKESPPYNRAGEMTPRSPSGYHIYNINEMVEVMGKRKKMPTTLGINMVTGIIFISPEGDDRQQEWTAEKLTHYSIEGKHVFVDLVRPSKSIDFHAGAKDTAQEIVAALGEIAGAYRAEGLREVIAAGEGGGAQKKGQILYDFMAQGDDEVTVAVGDEVAIIDDTKAEEWWMVRRLKNGKEGVVPSSYVEITGFMPLIPTPVVDTGISSVERNRLEEARLAKAAIGKTRTDSMDSSERKRDSKRDSKSAKSKPDPSKVRKWTDRSKAFTVEAQYIGLLDGKIQLHKVNGIKIAVPIAKMSVEDLEYVEKVAGVSLDEDKPLSSIRARGTSDSKRGSAGASVQRPEYDWFDFFLKSGVGPHQCERYAQNFIKDSMDESVLPDITPETLRTLGLKEGDILRVMRHLDTTLGRTGAKSKLRNVSFGGEEVIGNGEEGGLFAGPGGMLRNNTRKGRPAPAVQAGDVVDPKAFEQADESKPKAEERASTPPAPAAPEKPVARGFDDDAWEVKKPKESAAAAALPSGTASPPPAQPPIQKQVTGALADLSLLQAPLQPNAAQPTPTPAVSTIPALQPQQTAVQSPPVQPQQTGATPNFFTQIAQIGQHQQQQQAQAFSPQQTGFQAQARQRPQAPQNMAQNSLLPPPPQRPLSAPQNFMQQQNSFGPPPLQPQLTGVPQPGPALPGQSLTELNQQRLQPQIQMQPQVTGFMGQNQYQNGMMIPQPTGFTPQSQFGIQQQQQNQLPYTNGQPGFQGMAPQATGFGGFAPPQQPMQTGINSMLPPALQPQQTGANGFGTNAYSINNPPPVPPIPQQPTATPLSPQKTGPPPSIRFGVKPDAPKKLAPQPTGLRANLSQATPNNPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNQ9</accession>
    <name>A0A1Q5SNQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNQ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNQ9"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO89612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="284" mass="31987" checksum="5EF22182A2211114" modified="2017-04-12" version="1">MSETEHDSLTVQAVNSGSGNVAVGISIIVFMAIALYNAIELSVLIPLSFHRYRSLYFWALLTSAVLGVIPQTIGQGLQYFNLEPLWLSMFLSNFGFVFLVPNQSVVLYSRLHLVSQNPFVLGFVRWLIVFCYITIVIPTITLNVGSSFVPQSTAWVKGFDVMERIQVTWFTAQEILISTIYIWDTIRLIRLIRLVRSSPEADARRHKILYELLAVNIAAIAMDLSLVILQYKGLYFTQIELKPMVYSIKLKLEFAVLGMLVSLVQSHSSSSNPPTWGADRTTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNS3</accession>
    <name>A0A1Q5SNS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNS3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="5835" checksum="8E7700B9DBCB1FB1" modified="2017-04-12" version="1">MGEPRRIGDTWAMDGPTRPDFNIPEVNGQWATFSKSSLCGASPQTPVVGKGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT2</accession>
    <name>A0A1Q5SNT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein klf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="797" mass="89734" checksum="986A5D6E28FD77E9" modified="2017-04-12" version="1">MTEADEQPSKRRRRSRRAPSDRKFECTHEGCGKSYSRAEHLYRHQLNHTPKQIFRCDFPNCYRSFVRQDLCIRHRERHTTRGSQLQKRDSFAHDSLDESPHKSLIPVSSPSSPSMTAADYPFMTDPPAPSSKSPSNTTNNFSLPTTTPTTIDTAGVPVSGYTDFGVISQPDPMLEFDSMSNAYPIFGGETYNRSPFAMADDFAAWLFSEPLAPLGYGMMPFVQNQFYTNEPSYNNFCTVIPQHPMSVTSILDSTSLPAIISEEKRQELLHLMATRFNEAAYSAEGKRKDALMDGDLDNDRHVLSLRMMQTYIGSYWYHFHTQLPILHQPTFAADRTPNLLLLAVMAIGAATLDKAHGQAATETAAELASFIAWHLRWEIFMDADFRPPARLWVFQALLLLEVFEKLFSTRALHERAHIHHDTTLTLMRRGSSLIGRSSFDTPESKEEDESWTHWIKAEATRRVAFAAFVLDSTHATMFGHSAKMVAHELRLPLPCDEALWAATSAAEVARVQSSLQSHGVRPIMFLDGLKRTLNGQPVRTNTFGRIILMAGLLSVSWHLNQRDLQVSSLGVGQTLGGRDKWRTALLRSYDNWRRDFDEALGRATTTESECRDVLHGLAHMASHVDVADLQIFAGAGRLMGRSITARDYSTAREKTGRWATKASARDATFYALKFLKTCFSDPAVESGDYIARDDYLLNRPWVMYFAALVVWCYGFALDGPLRPPPALATHADRRRDMQAFLARVGGVREPNDLEGMKGRNGCLGMLMILRDSFANPRWELLGEAARLLDSCIAKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQP8</accession>
    <name>A0A1Q5SQP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQP8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQP8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000811">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="57921" checksum="B1D620442D2E1DB6" modified="2017-04-12" version="1">MADVGTHHFVKSSAKSDRVLVPQPSQDPHDPLNWNRFWKLSAMAISTATSFSQGLGPLALAPMFPQLMESFNSDLAGVVQFTGVCILVLGFSNFFWIPIQTSYGRRPVLIFSTLICLVSNIWRALATSYGSYMGACVLNGFGAGPAETSQPEIIADIMFLHERGAYNTLYFTAYFGSLMVGPIIAGPMAEHIGWRSFFWLNVGVLGVVLLFQIFLFPETKWHRVHPDEVAHEATTSANDDSENEKPVEATQQENVNVEDASERDPYLHKGHPSKQQFKLWQLDGNNIKTVLLSFWVPWKLLSFPIVELAAFIVSWSASCFLTLNLTQSQAFAEPPYNFNSQTIGFFNFAILVGAFIGLATNGPFSDWISMKATRKNRGIREPEMRLPAIAIYMVIMIIGNFVVAFGYEYKWDWRIIVIIGYTAAGIQVAALPAIASTYAVDSYKPVAGSIFVSITVNKNLWGYGFSKFITPWIEQSGYIKPIMLNMSLTALWCLCAIPFYIYGKRFRGWTAKSSVHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5STY6</accession>
    <name>A0A1Q5STY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000747">
        <property type="protein sequence ID" value="OKO91471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5STY6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF18">
        <property type="entry name" value="MALTOSE FERMENTATION REGULATORY PROTEIN MAL13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO91471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="38341" checksum="9C85A72D3C413245" modified="2017-04-12" version="1">MASPCDGCFVRRVKCDRQRPCQTCLMRQQTCTYLRVRKRPGPKGPRSDTTCKIEEIQRGATADVEMVTPAAESPVLHASNSRIPISTYYAVFDVFQARVHDIWPIADIEQLKCQLQNSDNDPLSHALAAALCAATLAQLRLGLTPNPCPRDLSATAEDFAKECLRIRLEHHYHQKPSLEALITSVFLHMYYANRDQITPATISLREAITYADLLHLGHTPPSDQAQSKKWQRELRCYWILFVTESISDIQQQIQVRMPRLEVTSEIQYVDILTTSAWVRSLLWQYSASRFMLSSSTSIEPLSFEYPLLIAKDYLECLSHVSIESLRSHGYGMSAFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUB0</accession>
    <name>A0A1Q5SUB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUB0"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO91601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="33065" checksum="2E1CC8CC9F5AB52B" modified="2017-04-12" version="1">MPQTPPDSTSAEDKPNVGQPEQAEAAPEETSSSSEAPAESKENDAAAKARERMERFKALKARAKSGTERNLKETAAETQRLATDPGLLNSISRKHAFASHNLLKADTEAAGEDFERKRAWDWTIDESEKWDRRMEKKQRHRDDVAFQDYTQDARKVYERQLRELAPDLEAYEKEKLAAIEKAAANGDLEIVETEDGEMIAIDKNGSFYSTADSVGFADNKPSRANVDKLVNDLRKAEEVRLKKRKERHGDEEADVTYINEKNKQFNQKLARFYNKYTTEIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUD3</accession>
    <name>A0A1Q5SUD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUD3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="111" mass="12979" checksum="71D91C1878B7C8E2" modified="2017-04-12" version="1">MFRTAPRMAGYVDSNTSQLPSLPRGRARARPKFDSQFLGVLVAIAFVFRENRVPYYQRLFQNHDGKRQWWKTSRSSYIMYPYLISVYGLGAATTYAMCRMVFGKKTWFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUG6</accession>
    <name>A0A1Q5SUG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUG6"/>
    <dbReference type="OrthoDB" id="4442598at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="604" mass="68062" checksum="561C66797D1FFCFB" modified="2017-04-12" version="1">MEDPSPSQLLRFTLTSSNPLSSETKSDSLLRERILSLIDAEWVSGNPPPALWCALKGVHPTTRKEEAKRLHSVNDISSLRTVIERLAVDKQGAKLLHSYFNATGVVRRCEENNTYSELVSALGDITTRLIRLELPRLGTDHGLQYAALDLSMPAFQSFLHDRQESFAPPLSFANAGSVINALFESIESVLFERPNYDTRYILASLTGEGEQAPREHPTLHEILHGSRDKDRRNWATYLCVLARLHSRDALITSWKQYMANFDRTSQDACHLAYNVVLALVRSRRSDEAAVLLEDISQRSKDNLPHIATLRNVQTLLEDPMVSEALPDLVKGCHYEELLESRLVDMESRLGIRWEELQWSAKGKGHVGITPDSPWTVFKDQPLLTIDGNCAGYEDPVRLWSEVQARGCSKSRNDLRQIVDVLNEQDGTAQRVAVWPVDQEMQDFFQSHFPSVEFQWNPEHSPLEFSETPLPALYDRSDKCTPATLGLLRARAAVNGVPQDTNKCLRLIQLGTLDMRFGAEDEWLRSGYIVAWDRQFGEMIALYVGAGSGIIDRGPTSPNAPFGAIVHIRPAQVSSNEHWPSDRHSRMPARSYYLDLDPSPDLGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVL2</accession>
    <name>A0A1Q5SVL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-sulfomuconolactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVL2"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="58"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="338" mass="37471" checksum="7C2A9E8DF8AE1EA1" modified="2017-04-12" version="1">MLTSTQSHAAILGKPPRISLTAGLSTRVDQHAVHAATVAFTATTSSLPLSQRIPLRSWDSHMHVVDPQQFPVSPSAVYQPEVHTLADALAFESSLGVEHLVFVQPSIYGTDNSCLLSALAKLGPSRGRGVVVVDPATAQPETLDKWHELGVRGLRVNLQSVGKVMEQSELEETLLRHAEIARPRNWIIEVYVPLKMVPMLESVVPRLGVPLCIDHFGSPELSCLAWAKNNSTFDPYVLPGFSSLISLLRAGNTYIKVSAPYRLTKDRQMRDLKAMAREFLGAAPDRVIFATDWPHTRFTGVDISPFTEWCLDLCTHDPELAEKLFRRNTERLLDVHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVL9</accession>
    <name>A0A1Q5SVL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVL9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="257" mass="28960" checksum="4E1D46D28F18BA87" modified="2017-04-12" version="1">MRSSLGAYSTQCERHHRHGALPILLTSRAMYHEAMHIFYMNNRIVIWPNTQSIGCVFAATGQLPFQPYRFSENPPGQPHIPAGRAHRNNVYLANLAWHDATKLFIQHVSLTGPRNIRNLEIVFPMIGLHDSFLYETPAYREWLNAVNYLALVLVHPDAANLNLVIHIRSPHSAFDWPFEDAVRKMDTTQTAGTGSGNPNPGARPPGMPLCNEKLAEMEVNLEKLATGDSYNSYAVGKGKEHPSPWLQDEWKRFISGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWJ5</accession>
    <name>A0A1Q5SWJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWJ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWJ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="103" mass="11263" checksum="D2C18E474C14B02A" modified="2017-04-12" version="1">MCVYWTVLEAGLRALGLILAAYALGIQAAPTGEHEKVSILDLVRNGTVVEESGTVTYQNSLPEPNKDDPYEVDGIKLYRHPGGIDVHPVYGEKRNITFHNGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYE3</accession>
    <name>A0A1Q5SYE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000738">
        <property type="protein sequence ID" value="OKO92885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYE3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="41954" checksum="4F00DF74C7AECA42" modified="2017-04-12" version="1">MYSLKKNNQQASFCKTTSIIIPEPHLADQPVEHENRRALGFIQYEKKNGRITIANVCMQLPINGLTMGFSIKDAHAAQNHLVGRHGDGLKLAALILSRDRYNPAAHQVQQIWKAALRKQEDTILPLLVDLLRNRPRVASLLALLKFTDHIQVVYVRGSARKVDVYFDKGQSTLKIHYRWLDFACMHHRSFCRPWSPSNLADTNAPFFCCHVVEELLVRSIASMFKAHPTSQPAEMKFIRQIGRRLRYLPHSIKLKPYPGGILVSWEDNKAESFRMLGPNGPDYHVMLHNDNCANTKTALLHDKAALPSDVVPCGCRQQFARQTHRMCLFTGLSHTSTYYATIALNEDRAFYGVPSDPGSPGAYEDVKAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ70</accession>
    <name>A0A1Q5SZ70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ70"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="393" mass="44180" checksum="829157B9E6BA1381" modified="2017-04-12" version="1">MSGLGGDFGRQFERETWTLYSVGVLGAVLRFVARIRRLGIRNLQVDDYLMMFAVVWYTILSVALNSVATGGGSNLMTDEDKANLTPKTHAERERGSKWVFVSEHAFILCIWSLKACMLVIYSRITEGLKQRKWINYIAIYVAIGFVATELSLFLICRPITNYWAVPTPDDQCSSYQYYEIVQGSFSISADVFMLLVAIPMLLQVRVPMKQKLILLLLFGMGIFVIVAAVLNKVYCLVPALISYVYMNWYFREATVAILVTNLPLVWSLLRDVFPALKSWTGGSKKGTDRYKSGPWTSKNSRPYGPHSQLRSGDFDMNDIQHNATVIPQKSNAAVSDVSLGGSDERDLSSDDGSARALRIRQDITVTVQHDSRPADYQSSTAHATRVPREREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZQ7</accession>
    <name>A0A1Q5SZQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZQ7"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="346"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="738" mass="82567" checksum="9D5E4FEB2F26DEFA" modified="2017-04-12" version="1">MPLFHDPDRRAQHRWSGDHNEPEQPAPGYPRDQAVQDDDRERCITEPTGRAIDSPSTEDFSPKFWANDRRAIINRIKESSPWRSQYQPQNTHTGESYMPYSSIPPPNSQADEQVVEQVSPNQQNTEELGSPAEIQRPRSALHSGDFREGSPHHPGEQSPQARFVEPSPSSPFPRLGTSPNTPWFGAAVFQSNQRQPNFFHERREAEHPIQTRSRAPSLGSFSSSYVLKAPTSPLVYQANNTDLDFSPRVDSAESLGPLERANRRRTLPPETFRHLHSTPPNLRSVNIGTPYSQGRQDGMFQPHHSPRRSLSSAYSLQLASTAIPPAFRARRPSLASEISPKAHAPMVGSYEESILRGRMSMNPSKPLDFTAQIGVLGKGKCKGHLRCPPHVTVPFPAVFYSYPTSGSGRSIADDSPSPYVGQIDLENSLPKDESSTTRRRKRHFSPSKAPEEIDLNETGAQRAPDIDSRRRREKKNRRAESPRCPPGGSYRIPQQGQLQIIIKNPHKTAVKLFLVPYDLSDMEPGTKTFIRQRSYSAGPIIDMPLSVRKNYGTDRPEASLNTTEDPQDKPILRYLVHLNICCPSRGRFYLHSSIRVVFANRVPDGKEKLRNEIQLPEPRYSPYKPVRENHLSTSAGARLAIEKASRRRSAGQGGFPHYMSSPSDAPLHWDVAEPVGAMGPSQTSYQSDTVYNKLNRGDAGYGGYPYASSQNGSENGESLLAKRLRGLDVHKHEAFDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Z6</accession>
    <name>A0A1Q5T0Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Z6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="6757" checksum="8008F9701B1D340A" modified="2017-04-12" version="1">MRSNIRAKVAYAEEKAEQEAPNASKAHAKSSGSGNNQKGQGSLLRSCSDKKTVHRNGLSSLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T224</accession>
    <name>A0A1Q5T224_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T224"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T224"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000125">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF131">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011822554" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="557" mass="61385" checksum="6B84C02719B4C1A0" modified="2017-04-12" version="1">MRVHSLLPLVLPLAAAASLPLGTEFARRQLPKEPTGVKTIKTANNVTIRYKEPGKHGVCETTPGVKSYAGYVDLAPDKHTFFWFFEARHDPENAPITLWLNGGPGSDSLIGLFEELGPCSVNEKNETVINPHSWNEVSNMLFISQPLGTGFSYSEKEAGSLNPFTGVFEDASFAGVQGRYPVINATMIDTTNLAAEATWEVLQGFLGGLHKLDPKIKSKSFNLWTESYGGHYGPAFFDHFMKENDKIANGTTKGIQLDFNTLGIINGIIDESIQAPYYPEFARHNSYGIEAVNETVYNYMKFANSMPNGCQDQILSCKTTNRTSLSDLAICTEAANMCRDNVESPYYVFSGRGTYDIRHPSQDPTPPSYYINYLAKDEVKNALGVDLNYTQSNADVYYAFQQTGDFVWPNFIEDLEDLLTRPVRVALIYGDADYICNWFGGQAVSLATNYPHSKEFRAAGYAPFTVDGVEYGETREYGNFSFTRVYEAGHEVPYYQPVASLQLFNRTLNGWELPTGEKKLTPDFGSDGPATATHTAPSVALPTPTSAGGSSVGGESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T254</accession>
    <name>A0A1Q5T254_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T254"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T254"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000055">
        <property type="entry name" value="C6 transcription factor (Ctf1B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="877" mass="98392" checksum="94214A759A58A53A" modified="2017-04-12" version="1">MTDSDSGKRKASVAGLSAHNRPVKRRASKACCCCRARKVRCDVVENGSPCTNCRLDQVECIVTESKRRKKSRVDVDTNHTSESPGEISEENPLGSLGLHGMADMEPTSPSQNSVDIDHGQHMPHLLYQSQAHRIGSDDRFRRRMAPNPAVPSSMPLANATLQIQQLLDPNFANSRTANGFLPDYIRGLPARLQKEDIDYLAAKGALTIPDVTLRNELLKAYIHYVHTYMPLLDLEEFLQTIVQNDGIHRISLLLFQAVMFAGMAFIDMKHLQAAGYQTRKAARKIFFQRARLLYDFDYEVDRISLVQSLLLMTYWYETPDDQKDTWHWMGVSLSLAHTIGLHRDPGNSRMDVRRQRMWKRIWWSTYTRDRLIALGMRRPMRVKDDDCDVPMLTLDDFEFQSFSPEIVKMVGDSEILQNVSHQRELALMFIEKAKLCLCVSHVLSAQYSVLSHKFGGTMETTMMLVPKKSTAETFEVRRCDQELEDWLANLPVETQYSPSDGHKLSEANEVLHSHRALLKMVYLTTSSALHRPQVLPAVPYPSTDAELQEMSRNKVRFAAVEITNIAQDLHVLDLTRYYPTTGVTVLLPAVIIHLLDIKSSDPSVRMTSLQRFYQCMRILQRLREIYASADFATSFLEAAIRKAGIQLTVAPQDVQSSRSRPNRTTTTAASTTTPSASTSTDHFDILSRPNALTPPPDSLAQKIPDLTYPKPGPAPTRAQSTADLFASTPPHSDGSENGSTNNLNPNYASHDAFAIPDLHSEMSLTELMDLANDAEVTQNDFDALINFDDAGNDFFAEDVQQQQQNQHQHHQSGVSVGVGAEEKAYEFDMKVLGFDTEPKAFDFAHLAESRGHGVSAEVQRLGLTADLDTDLGIGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2G0</accession>
    <name>A0A1Q5T2G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2G0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="25958" checksum="B9741F722CD01493" modified="2017-04-12" version="1">MKFLCLHGAIGNIDTPIQTPASGHLRLIVELLYAGFEEYFGAGPHYRWSEDGGIAEESMISRVRKIPVGHNPEDVMRDLVGDRDVVWKNHEEVMQYLYDTLEENPDIGGIIGYSEGASIAATFILNEQRRQEETGRERRIKCAMFVTGWPPIDPHKGVILADENDDLVDVPTLHVVGANDPFRHGAYALYNVCDPDTAAFFDTGKGHTIPRSGLVIDELGDAVRDLIAKSQEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N4</accession>
    <name>A0A1Q5T5N4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000180">
        <property type="entry name" value="MFS monosaccharide transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO95508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="530" mass="57783" checksum="84BE892565B9F445" modified="2017-04-12" version="1">MPGAALVATADTSRIEAPVTLKAYLMCAFAAFGGILFGYDSGYISSVMGMRYFITLFSKDQNATAISSSRKSLITSILSAGTFFGALAASDMADYCGRRTTVMIGCFIFAVGVSLQTASTYTNLLVGGRLVAGLGVGFVSAIIILYMSEIAPRKVRGSIVAGYQFSINVGILLASSIDYATQNLDSTASYRIPIGIQMLWALILGGGLFFLPESPRFFVRKGKLDEAAHVLSRVRGQPVESEYIQNELSEIVANYKYELEVVPQGSYLASWFNCFKGGLSNPASNLRRTILGTSLQMMQQFTGINFIFYFGTTFFQQLGTISNPFFISLITALVNVCATPISFYTVERFGRRPIMLVGAIGMVICQFIVAITGTVDGSSKAAVSSMIAFICIYIFFFGCTWGPGPWILVGEVFNLPIRARGIGLSTASNWFWNCIIAVITPYLVDGDKANLGAKIFYLWGGLCITCVVYTYYLVPETKGLSLEQIDRMFEESTPRTSSKWVPHSTFSADMGFVKREGSVSEVEEVKNTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5U4</accession>
    <name>A0A1Q5T5U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyketide synthase HetM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5U4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5U4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="438"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="802" mass="89030" checksum="37C074659B43AFFA" modified="2017-04-12" version="1">MGPPMMPPSGFLVDSIMKQQEVRALYLPPSVIEQWAIEPAAYQQAENLDFVLYSGGPLANSVGNRLDQITDVCQMYGSLEMGQIQMLVPNPGEWDYLEPNPAEECDFQEVDEGEGVYELVLHPDKKFIGQRSLAHTFPDVTNEWRTKDLFKPHPSKPGLWRFHSRTDDIIVLASSHKVWPIPMENTLAGDPLIGGALMVGNGRPEVLLLVEPRPGPQVDRMSKKEFIDAIWPTISQANANAPEYGKIRRSRIVLSQPNLGFFRAPKGTISRKPTESLYAEYIAAAFIDGTTDEQSEIGILENHWLDEAKRFIGSVVHDIRPDITLRESDDFFVAKAMDSLTVLELGQKLRLGLIRRMNPEKNTINFWLRTVFENPSIEALAKATLDAVFGQVDSDEYNSRGFNLEHVLEECVAQLPEPSGLEPELELPTEDIKVVLLGSRGRLGPYIVRDLLNDPRVAGIKCLDRGGSGQAEFQRRADELGIDVDASNARLQFISMELSHPNLGLSQNQMDEILHHADVIIHNVWAVNFALSLSSFKPEMLKSLNTVIEIANKAPSRPRIVFASSTGTVSAWAKAVAPNVPVPEEVIKCASAATLTGYAQSKHVAERLLAAAGAKLKIPISILRIGQIAGPTTIGDGGKWESHDWMHSLAILSKACGLVPSDVAEIDWVPVDQVSRIVSDITLQEKHEGETGTPFVQLYNVLHPRPIQFSVFADALQSCISSSRQVGFHAWVDHLSGLTPDKLSKEAETEKTRILPFFQAIAEEQYPKFSLEKAKKASAVMAEMKPIDQELLTKWCQQWTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Y2</accession>
    <name>A0A1Q5T5Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Y2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Y2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000015">
        <property type="entry name" value="30S ribosomal protein-like protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="140" mass="15832" checksum="8E4C1F22DB1AF8A1" modified="2017-04-12" version="1">MVFILGVNFPERNLLKKSLETFFGVGGHTSSRLLARFNIHPTCRVGELANKQVLDLTAVLSDMKIENDLRREVLNDIKRLKETGTYRGRRHALGLPVRGQRTRTQVGCFSFAVSYILRLDILDTMLGVFGCFVDMVLMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6P0</accession>
    <name>A0A1Q5T6P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cocaine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6P0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6P0"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="323"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="589" mass="66604" checksum="54447D52D51312F8" modified="2017-04-12" version="1">MPIPYQVAYKPLTKPEVGVNGYVEPTPGKTEVIPKGSAPFGARTLDSDVRIDHDVEITVRDGCRLYADIYRPNNDEKVPIIISWSPYGKKYSALEMIFNVCAWACCLERGDVSGLEKFEGLDPAWWVQHGYAIASVDVRGAGNSDGDTPCMGLQEAEDAHDVIEALAKLAYCNGNVGMAGNSYLAIMQWHAAAQNPPSLKAIAPWEGSGDIFREQFCRGGWFNMSNYDLITTLVIKGNSGVEDFAEMYRRSPQANVYWNDKRVDMTKINIPCFITGSDFSQIHTMGAIRGWMEANTDKKWIKWSGYQEWYELYAVPESYLELKKFFDKYLKEIDNDWEETPKVRWATLPFGDKDVTHDIVLPDFPVPDTDYRTLYLAPNGSLASELPRETATSVYNSEDRWSISKFKYTFTQQSRLIGIPKAELYMSCDALDDMIVFIQLRKLDKDGKELSQLQFPFARAPVNSIDEIADKDRQSLTLHNGSMGILRASQRKIDSSRSIHPQFPFHPHDEVQKVPKGEIVKLEIGIWAMGVDYEEGESIQVDILGQYPGFTEVAAFSKPRPEHEKNKGEHVIHFGGEFPSRVILPFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T7Z9</accession>
    <name>A0A1Q5T7Z9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T7Z9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T7Z9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012118023" description="FAD-binding domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="421" mass="45865" checksum="08E1D4DAD0276462" modified="2017-04-12" version="1">MSNLRVLVVGASIAGPATAYWLAKTGAKVTIIERFPQLRTNGQNIDIRTTGVSVMRKIPGMEEAVRANLQSIDGISLVGKDGRPYGTMTSTGDPDRQSLISEYEILRGDLSRILYDLTKDHESVNYIFGEQVASMQQPETSDGPVQVEFMNGTPSSEYDLVVACDGATSRTRAIGLGCAMRDYIQPINAWATYFSVKKDLLSGSQIGQAYSAVNGRAVGIGPDPSGGNRVTLMGIKPRNDHSSMAKFREANKLGTDALKDFVTQQFQGAGWKCDEIVQGMIEADDFYGSEWVQVKTPTLHKGRFVMVGDAGYAPGPTGTGTSLALTGAYLLAGEVGKHRGDLAAGLKGYEEQIRPLIDRMQKIPPLVPGAFAPQTAWGIWLRNMIFAFLCWSRLPWLFDKVFGTASAHSDGYKLPEYQWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T834</accession>
    <name>A0A1Q5T834_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T834"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="140" mass="15967" checksum="0DFB719229982656" modified="2017-04-12" version="1">MPSWYINHSPNIFSAAEKAQLAKSITNIYASHGLPTFYVQVHFTEYDPSSSFIGGETHAKFAGITIYHLARAFQSDESKQRFLSRVDQVLNPVFEPKGMDWEYFITEAPRDLWKINGLVPPPAGSEGEKEWVRVNRAVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8B4</accession>
    <name>A0A1Q5T8B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8B4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8B4"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="170" mass="18693" checksum="BCA7436031AACF38" modified="2017-04-12" version="1">MSDEGIRPPARKLDEFEELVYEYTNRMGLGNEEHWDVNARDCNLRFESATRGPPAKVSFLLNITPALSNYMGNLHGGCAATLIDVLSTTILLGISEPGKFSFGGVSRNLKVTYLRPVPTGIEARVVCEVIHVGKRLALLRAEIQKADTGDVCVVGEHEKANTDPEVNQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8I6</accession>
    <name>A0A1Q5T8I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity glucose transporter RGT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8I6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="440" mass="49335" checksum="7C5A88C786001F97" modified="2017-04-12" version="1">MFDEYIQGKALRRLSRFSCSVGFLIEGYQAGVLGGVQETKPFLNAIGNPTGTETIPMIASSYTLAAAFMSCVVMLIGMPLGRRRCIIIGNAFIAIGGVIQATSYSVPQIIVARVLCRMPIAFQSLFAILSGVSMVFLPDTPRWYYARDNIPEGDKTLSRIYGVYRNGTTNHSTVPEIQAMKQNIMENFHVEEESDNRLTLLSLIWDTTPLRVGRRVRISFLILAIQQSMGINMLVYYMTLIFTNVGLSDFLASLLAAISLTVQWVGSLLCVVTIERIGRRRIMMWTACIETCCMLIFVVLNTLQDKTVSTQWAAAMIMFPYMFFYGWGWVGCPWLYGPEIAPLRYRHIGSAAGLLGVWLFTFLTVFAGGIAFETVGPKIWIWPLIFNAIAFLFVYFMCPDPTNKTLEEVDALFAKDEAILNRLNHLVDEKPTAQEIEKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8K4</accession>
    <name>A0A1Q5T8K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10742</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8K4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8K4"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO96567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="483" mass="54273" checksum="E2D98BD80E596674" modified="2017-04-12" version="1">MSASNDVYQTPLNSRYASTEMKYLFSPRMRFSTWRQLWIWLAESQKELGLPITDEAIEQMKAHATIQDDEFAVAAEEEKRRRHDVMAHVHAFGQVAPAAAGIIHWGATSCYCTDNADLILLRDGLDILIPKLAVVVDKLSQFAQQYKDLPCLGFTHGQPAQLVTVGKRACLWIQDLLMDLRNLERARDDLRFRGVKGTTGTQASFLQIFEGDHAKVEKLDELVTEKAGFSSAFIISSQTYSRKIDVDVGNALGSFGSTCERIGIDIRHLAMLKEVEEPFEKDQIGSSAMAYKRNPMRSERLCSLGRHLQNLPKDALDTYSAQWFERSLDDSAIRRISIPELYLTADACLILLNNVSSGFVVYPEVIKRHVNDELPFMATENIIMACVKKGLSRQDAHEEIRVLSHQAADNVKKHGKDNDLLDRIRRTAFFNPILPELDNLLDASTFVGRAPQQVEKFTATEVAAAIKPYASYIAKGETSALYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8W8</accession>
    <name>A0A1Q5T8W8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8W8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8W8"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="218"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="418"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="545" mass="59910" checksum="2336D57523FE360A" modified="2017-04-12" version="1">MAPSKPRSGRSLADQLADLEDPTPKDFDPEDIDRDEQSSDDEGAGKESDLNAGREHYQSVGKGKLRKQEPVDLGKQYAGARVSRDDLDADSDDDPFAARTDDELTSDQEDDGDSASAESQSDEDLVSGSEEEQSDDDESDRMDDENDHDHLSGSEVPEVDRPRRKQNKTHNGIGHLSDMHDDSGRKQGHSDDRDELRRLMASDQKTIAATISQAAKADAAKGKAVKEQRTTFDALLNTRIKLQKGLGAMDELVGVVVEKEEGESVEEEKRNSEAIKSAENAALALWSTLEELRIALADAHTKDGAKKRKRQDPITNSTSTTSLWERMSDLESESLLHRRAVLDKWSSKVRGTATSLPNARGKLLGSASGTQKITAVLDAHVGTEIGDRANKRARQTSAANGSTPTGLPEPVYDDTVFYQSLLRDLVEQRMSSSEAMTGGLDTLHQLPSRLPIHPITGMRNDKNRKEVVDTRASKGRKMRFNVHEKLQNFMAPEDRGSWTVRARDEFFASLLGKSASGLLGEGDESASDAESDEDREEGGLRLFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAJ4</accession>
    <name>A0A1Q5TAJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAJ4"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="694"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="745" mass="81708" checksum="8F705ADFCE368BFF" modified="2017-04-12" version="1">MAMNKIRGAFAVPRKGETFELRAGLVSQYAYERKESIQKTIMAMTLGKDVSALFPDVLKNIATADLEQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLIRALAIRTMGCIRVDKMVDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPSMCLENGFLEMLQEMIGDPNPMVVANSVTALSEIHHTAPETQAMQVTANTLRKMLMALNECTEWGRVTILSTLAEYRAADVKESEHICERVAPQFQHVNASVVLAAVKVVFLHMKYVGPELAKNYLKKMAPPLVTLVSSAPEVQYVALRNIDLLLQKQPDILNKELRVFFCKYNDPPYVKFQKLEIMVRIANDRNVDQLLAELKEYALEVDMDFVRRAVKAIGQVAIKIESASEKCVNTLLDLINTKVNYVVQEAIVVIKDIFRKYPGYEGIIPTLCKCIDELDEPNARAALIWIVGEYAEKISNAGDILGGFVDGFNEEFSQTQLQILTAVVKLFLKRPEKAQGLVQRVLQAATAENDNPDVRDRAYIYWRLLSNTSDQDATKNIVLSDKPPIVTTISSLPPALLEQLLQELSTLSSVYHKPPEQFVGQGRFGADAVQRAAIEEQLQNARENPLAAAAAAAVSGTTPSAQAQNNVENLLDIDFDGGAPASAHKEPSGEMSGLEGLAGTPVRVQSPAAGTPAPQASNNLDDLLGVFGDSGPSQPSSSGANGGAAADLMNGFSGLDLSGNSSPPVHNQPQKSSQDIMDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAW6</accession>
    <name>A0A1Q5TAW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAW6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="54625" checksum="5B154AAC289488E7" modified="2017-04-12" version="1">MLHSTGPDDVRDMFTLIQRERRIILISIFVALAQFQYGYDSAAVSGFQSMPGFLAIFGYVDPTNTLGFGIRTSVQTLIQSLMQLGGFFASVFIFKYGTHISNRRGLWIGCGFSIIAIILQMSSVHFAALYAGRLLLGISNGFFLTYSATYLGEIAPTNLRGSAVGLVTFQTSFGALIGVLIDNYTTKYQSRTSYLIPLGVMFVVPVSLSLGLMFLPESPRHYIRLGSEEKAEDSIRILRGIKDHSQLVAEVASIRGALMMENARSETTRLVDAFRGTDLKRTILSMCCSIGQTASGVIFFSSYSIYFYAEAGVKNEFVWVMMSLAIALTGNMGSFFVMRFIERRMLLSLCSIINAFVMFAIAGVYTRLSTGSYTAAQVLVAMGTLFTWVYGIGQGPVLWALTVELPSQRLRSKTVGLATGCNYIFAWVATYCSPYFINPTALNWGPKYCYIWGASNLILGVWAFLVIPDVKGKSLEEITGSMIGGSEEKTGNTVEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB79</accession>
    <name>A0A1Q5TB79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_10262</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB79"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1510.10:FF:000002">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="142"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKO97468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="938" mass="100271" checksum="66654A0922BEE01A" modified="2017-04-12" version="1">MASKIDGTAIAKSIREGLKAEIEKTQATNPRFKPNLVIFQVGNRSDSSTYVRMKLKAAQEANIICTLINVPESSTELELVQEITKANNDPSVHGILVQLPLPGHMSEHTITSAVADEKDVDGFGAINIGELAKRGGRPLFTPCTPLAVMELLKASGVDPAGKEAVVLGRSDIVGSPVSYLLKNADATVTVCHSKTPDIARVVKNADIVVAAIGQTEMVKGDWLKPGAVVIDVGINYKPDATKKSGERLVGDVDFESAFQVASQITPVPGGVGPMTVAMLLKNVVTAAKAYFEKQKDRHVTPLPLKLQTPVPSDIAISRAQYPKPITTVGSEIGIAPHELEPYGHTKAKVSLDVLDRLSHRRNGRYILICGITPTPLGEGKSTTTLGLTQALGAHLNRIAFANVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIETRMFHEATQKDGALYKRLVPVKKGVREFKPIMFRRLKKLGINKTNPDDLTEEEIRRFARLDIDPETITWRRVLDVNDRHLRGITVGQAATEKGHTRETGFDISVASECMAILALSNSLDDMRERLGRMVVATSRSGDPVTCDDIGAGGALAALMKDAIKPNLMQSLEGTPVLVHAGPFANISIGASSIIADKLALKLAGTEPDEDHEAKTGFVVTEAGFDFTMGGERFFNIKCRSSGLSPDTVVIVATVRALKVHGGGPEISPGAALHEIYRTENVDILRAGCVNLRKHIANAKQYGVPVVVAINRFETDTEAEINVIKEEAIAAGAEDAIPANHWAEGGAGAVDLAKGVLAASSKPKDFKLLYDLNGSIQERIERIGQAMYGAEKVEFSELAQKKVDTYTKQGFSNLPICIAKTQYSLSHDPALKGAPTGFTVPIRDVRLAVGAGYLYALAADIQTIPGLPTAPGYLNVDIDTETGEIDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB85</accession>
    <name>A0A1Q5TB85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycine-rich RNA-binding protein 4, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB85"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000684">
        <property type="entry name" value="Putative glycine-rich RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="19102" checksum="5B7A47DFA0DD5064" modified="2017-04-12" version="1">MSKLFVHGLSWHTNDDTLREGFQQFGEIQEAIVVKDRATLRSRGFGFVRFATDEEADAALNAMNNQEFDGRVIRVDKAFDRPSRPDGGFQGRGGYNQQPGNGYQGGGGGGGFGGNGGGYQRGGYGGGYQQQQQQPYGGNGGGNGGNGGGNGGYGGGNYGGGYGGGANAGYGGGGGWRNNQAPAPEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBR5</accession>
    <name>A0A1Q5TBR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_9963</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TBR5"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF170">
        <property type="entry name" value="DYNAMIN ASSOCIATED PROTEIN 160, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="17">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="17">
        <location>
            <begin position="141"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="17">
        <location>
            <begin position="292"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="1240"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="391"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="701"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="896"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1217"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="772"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="979"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1161"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO97672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1281" mass="134629" checksum="F96E13ED4409ECE4" modified="2017-04-12" version="1">MTDTPQRHPNLNLTAEEKRVFYQLFQAADTTNLGVITGEIAVPFFEKTHLPSGTLGEIWQLADKENRGLLTPSGFGIVLRLIGHAQAGRTPSDELALQPGPLPRFDGIVVDNTPAPPESGAASPPPGAGPPIRVPPLQPEDALKFLSLFEKSDTSNGMISGEIAKQIFERARLPNEVLGRIWNLADTKQRGALDATDFTIAMHLLTSFKSGALRGIPQTLPPGLYEAAARRGSGRGSFGARADVPPVPSIPKQFTGPQRTGTPMSPNHTGRPAFGGPLSAQSTGDWLISPQEKAHFDGIFETVDTGKVGLITGDQAVGFFMKAQLPEEVLAQIWDLADIDADGQLSRDEFAVAMYLVRLQRGGKEPLPQVLPPALIPPTMRRQAPIPAVAAAPVPPSAPAPVPRSAADDLFGLDSPAPPVAQTQFPQSTGGSNHAFHTPGSPVSRASPSVPATSFKPFMPTSTFGQSLQPQVTGASAGTPGAIRSPPPPSDDLLGDNDPEESKKLTQETSDLANLSNQIGSLAKEMHTVQEKRTSAEQSISQTSQQKRDFEARLAQARAMYEKEVANFKALEERLRVSKAETTKLSQEYALIEGSRQDLHNQYTQVSTALASDQQENASLKEKIRQANAEVAQLKPALEKARSDARQQKGLVAINKKQLATVEGERDKIQGEIDTLAKETPQYTENATPVSSVAEVASPAVSTASQNTNPFFRRTATGSSSERALSPEGPTDQQKAFDNLFGQSFAAPSVAGPPPTSFRAESPLASSKSPITSNVPTPSASPVPAVSVPGAFPGVASEIPPPSQSRQMTPNFLPFGDAQSVTSSTMVSPPASRFGGPDASGIATPSQDASDQGGPPSVAASSDYSRAPTFEGTPARSPFDEVPAAFDAAPIAAAPTTAVEQPAAALSPASTGNQEPAKDLSFDELFGSKAHKRSESQNQNDFEEAFATMKQHSDDKTNGGAAAAPSSEFPPIQELHHDEEDDESSDDEGPLGFDDNFTPVSPTSKKQADSIDAAQLAAFPVPGSAQPPAADAQASPPQYEATTAGDASHMPPEFRGLLPERADPTIAPDAPHSVDSTTGAPVIANESQREVVSEAAAPALTGGAKTGGPDFEAAFAGLNLAPATEADDDDEDDEHEEIHDHKNTSDFDFSFDSPSQAKHGASSSTDAGQGGSSDFFSFDNNVTAATAQSTTSQNGGDSKAAGPDWDALFAPLEGAKPVAEEPANGASSKSPGWALNNDSGEDDLILQRLTGMGFPRDDSLAALEKFDYNIDKAADYLTSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCM3</accession>
    <name>A0A1Q5TCM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="16891" checksum="F975617393579706" modified="2017-04-12" version="1">MPLCVAAEEGRTEVVETLIKAGAARNHQITKAGDTPLGLAIRSGHESVVKLLLNAGASVHLRNSKGEALMDLANHHPTLLHMIATLDKVGRLAEIADEHLNSSIDHEFKATVIDFVSVSGVLTPDAVEIAVDELLQTPWVSTTPDTSSASFRWLPASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDB5</accession>
    <name>A0A1Q5TDB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAB1-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDB5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="471" mass="49222" checksum="5C9D5B200DDA4972" modified="2017-04-12" version="1">MSASPSNLQSTKRPLEDPSSPSGPNDQPEAKRPALDKVARSDAEAEAETEVSTTQIPSVEDTKDTQGDTVVPDAPNGKAHPETQPIQSTASHGERAGSQTDSHPPQDESSWVHIRAVISSPEAATVIGKGGENVSQIRRMSGAKCTVSDYSRGAVERILTVSGAQDAVAKAFGLIIRTLNNEPIDAPSTAQSKTYPLRLLIPHILIGSIIGKGGSRIREIQEASGARLNASDACLPLSTERSLVILGVADAVHIATYYVAVTLVEQLTERFGGPAASAYATRSGGPAGAVPGGMQVVPYVPQPAGGQYGHPDTFKRNHPHPNRGQPGAYGVPYLQGQAPAPVAQPAMPYGAAPHTPYAGATPHQPNPYVGGPQPAAGRGGAPTAPAPVGGAMPGQPLTQQIFIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQENSNERLVTITGTQECNQMALYMLYSRLESEKHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDC0</accession>
    <name>A0A1Q5TDC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDC0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="766" mass="87309" checksum="E6A5688FB832D6A3" modified="2017-04-12" version="1">MSFGRHAYRHALKPAATPPLDHLWISDDLLAATFRRFANGQRRHGSCVPGPLEARRRLAKRRNTALAGFTGSAEDIACLFGRNGREHMKWTDHPWQRAQLETQGTPNKENLQIQLNAYHFEDLRSYSVATAEASLPFYDQNTEPADTFSDNPQPSSHESTPASRAGLLDDFLEQKNWGLEDTRDFARQLRIDLQREPKYSRQIFDKLLSRSTTDLKHAIQFLDDPFLNTRGSGNYFAAVSLFVQAKNKRSARTAVLNSVCRALELGLVPTDELCLIVEAIPKIIVERNQTLGEWDQKALLKHYRSMWKAIGRCTILGYHDLERELVDVWLAELVNLRSLRFAEEVVVATHDASSDSRWPATLVMAQLDELEMTTSLPTFYQMLSQLDADCAAKCIVQVTESLALPGTPIQSRYQLLDRWRHCLSNLSNLPALANSQVWLDLPFAYNEDTSKTEQAPRILPVQQEIILRLWALRTLSRSLGPMYHQGPRPTDKPIYFLLGLYETSTKSTDGSFLSDLMRGIHTLNLPYSSLLLLAVNIKMKKNITKNARRTLEKLETSQVSLTDVWADPSTYNGIQALFHGTFEQMFRRLDITSPESAEECLHLARVGDSKSIWSVLRLLRNHTPFKLCLNKAWVPLPHPDEKALVRYHAGPRDSQSPDPYAAVDFVHRLAVAISCSNNLTPSRSFHLIHLLYDYLRRHGGPVYPSLVQAMYHAGVVRYRREGRRVSPTQYEYILWIVSKFEGREVARQLRAPAQIGLGKPDQWDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDE0</accession>
    <name>A0A1Q5TDE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDE0"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="56412" checksum="8BD39CEFF038E98E" modified="2017-04-12" version="1">MEEPQSMDGALSLPVRASSPSPSVPATPAISSYSSPDRTFSSVSSHSASSATSADARSTISTSSRRHGYVRACGAEFADSARHRDSVMSLGSIAHLQYYFARTGLLDGKTGRGKEFKKKNRGNVPRVLITPNEQHIENLVASPTEMVDEAGDEAGFEDEEGEVMLPPTVSTYSIKTHHVPPPPDVVSLRRDLQVALDRAESNIEAIENGVEPPPRAPIRTSLSPGDIIEGSDDDTARDVPSPQTKEEAQGMCILDDVTMAIRAAKIYYTAHPLPERLGSIKSERDIRKDLLHVLDVLKRWAARHFAMGLRDEERDVIKGWIAGVRTMLVREKTLEDLEAQERENWDWARGDWAGRERAREESFLRSLMPGGHTLPEWTAIDDTPLDSLPSPFLERFRDGRILVQLHNIAVKKSKRHFGEIKAYHQDIAKPYRQAENLRFWLKAAELRWEMRKQVDVMGVVQNTSEVAWRQFDAALLAWCKTVREELVRDWMEANPGRPPSAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDG3</accession>
    <name>A0A1Q5TDG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDG3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="10140" checksum="970C5BADFCF3A945" modified="2017-04-12" version="1">MASKISRDQDSEARKQFLEYYLSRDITSFHSTFRPQISYARALLEFYRAVEYFEYIRIERCLYRFEIFCQIFCSAQFTSAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDP2</accession>
    <name>A0A1Q5TDP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial Rho GTPase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">PENSUB_9443</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDP2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000127">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000185">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000572">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000878">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000531">
        <property type="entry name" value="Probable catabolite repression protein creC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 24" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Miro" evidence="27">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="26">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="27">
        <location>
            <begin position="422"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="24">
        <location>
            <begin position="980"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1071"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1102"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="OKO98345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1182" mass="131316" checksum="C0D45EEA25BAF73E" modified="2017-04-12" version="1">MATVRICVCGDEGTGKSSLITSLVKGVFVTNKIQPILPQITIPPTIGTPENVTTTTVVDTSAVPQERNNLAREIRKSNVILLVYSDHYSYERVALFWLPYFRSLGVNVPVVLCANKSDLAAEHSEAQVIEEEMLPLMSEFKEIDSCIRTSAREHRNVNEAFFVCQKAVTHPIAPLFDSKEAALKPAAVSALQRIFYLSDKDRDGYLSDKEIGDFQTRCFGKPLSDEDLAHIKDTIQKGYPESVTESGIDCQGFIHLNKLYAEKGRHETVWIILRAFQYTDNLSLQENFLHPRFEVPPFASAELSPEGYRFFVNLFLLSDKDNDGGLNNAELESLFAPTPGLPASWADGSFPSSTVRNEAGHVTLQGWLAQWSMTTFMSPKTTLEYLAYLGFESSDRSNTSTTAALKVTRPRKRRRRPGRIGRNVVQCHVLGAPGSGKSALLDALLSRGFSTTYHPTIQPRTAVNTVELPGGKQCYLIMDELGELEPAILENQAKLLDQCDVIAYTYDSSDPDSFAYIPALRAKYPHLEELPSVFIALKADLDRTTQRAEYQPHEYTAMLNIPSPPLHVSVTWTSIQEVFVHIAEAAMEPSTAFPRSEEDVEGKWMAWGIARNCIRVLPPPPPRYTIPIAYAAGAANGMAVPVVETNNTISHPEGGCPLQVGEGTYTLKDDLLLATPPPHPSEAPIINPNPLATVPSPPTAGVKVCLVSLDPRKKPPTFLKSGITAPPFGDGNAALAPAPVPAKDAAKRRKPKNNIIKSSSSFVSRVITHETSAKRLSDRDPNGVFAFANINRAFQWLDLNSAQKEEHLTKVLFTKAHMLCHDINEMTKTSSHLDIVMGSSAGDIIWYEPMSQKYARINKNGVINNSPVTNIKWLPGSENLFLASHANGVLVVYDKEKEDALFTPELTGHPEKDPARLPIEILKSVNSKNQKTNPVALWKLANKRISHFSFAPDHRHLAVVLDDGSLRLMDYLKEEVLDIFRSYYGGLICVCWSPDGKYIVTGGQDDLVTIWSFPERRIVARCQGHNSWVSAVAFDPWRCDQKTYRFGSVGDDCRLLLWDFSVGMLHRPRAHHQASTRHRSSLVVPATQTSNRHRADSGGNRMRSDSNRTEKFEGDVDPLASHPVEPRARTALLPPIMSKIVGEDPLCWLGFQKDCIMTSSLEGHIRTWDRPNDSVVKQEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEG6</accession>
    <name>A0A1Q5TEG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endochitinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEG6"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010378901" evidence="7">
        <location>
            <begin position="20"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="31"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="330" mass="35016" checksum="E32E34AC9E488F59" modified="2017-04-12" version="1">MHFSTILASVGILATAVSAIPHKLHTRDSGGQNVVYWGQDTNVQDLSKYCTSSSGIDIIVLSFLYEYGNGNTIASGTIGNQCYISPAGVPQNCDGLATDIETCKSAGIKVILSLGGAVGAYSLSSQAEAETIGQNLWDAYGNTAGNSNVPRPFGKTFVNGWDMDIEAYSGNQYYQYLLAKLRSNFASDSSNTYYITGAPQCPIPEPNMQVIVTNAKFDYLWVQFYNNPGCSVNGDINFNDWVSNVANTPSAGAKIFIGVPASPLAATGTSSGSQYYLEPTSLATLVNQYKSNSAFGGVMMWSAGYSDSNVNNGCTYAQEAKSILTKGSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFG5</accession>
    <name>A0A1Q5TFG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFG5"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="182" mass="20037" checksum="1C32DB42489BA019" modified="2017-04-12" version="1">MATQRHYYQPSAYPMNMPSKAPVPASMYPISRVPGSPPDYSDASTTAGSRTSGGFTFSSAGGSGDYESSSASYSGVDVVDVLSDRMQDAFDPTPLDKGLARQAQTSGHLNAKQRELLELQALAQRRLKGVRANFAEGVKTARETKRDLEWTQKRVSALKSKAEKAHPEEYRRAAKKYTYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFK8</accession>
    <name>A0A1Q5TFK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFK8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFK8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO99016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="16273" checksum="C347262273CE9358" modified="2017-04-12" version="1">MNTTKMSILMLYLRIFIQRWFRITCHTLLVIIASYMVAAFFASVFQCTPVPRAWDKTIAGSCIDITTNWYANAGFSIATDIIILALPMYPIYKSKTPLKRKIALMIVFALGALRYRLLSMDDNRRKRRDNLRLLANDVGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFL7</accession>
    <name>A0A1Q5TFL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="139" mass="16160" checksum="8A56F8E7000D770F" modified="2017-04-12" version="1">MAIVLGIGLGVVLLIVLSLILTIVINRRDHRAFLRSRKNPDERLRSLDAVSPTRTLEQWWTTTKGAMGLSEAVDSQFVCAVCLEQVARSEEIRELRCLHVFHRECLEKWFLGDHYNCPLCHRAYYVPEHPPRNDYVWMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFT9</accession>
    <name>A0A1Q5TFT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFT9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFT9"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000051">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000142">
        <property type="entry name" value="Protein tyrosine phosphatase (Pyp1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="188"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="443"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="622"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="741" mass="82438" checksum="A3FAB9CCB55B528A" modified="2017-04-12" version="1">MTGPGRSPSSPWVQSAQGRANQPFHPGLSPTQTSMHTSSERPSPNYFGITVDHSSNPPTSNAGPHLQRNWASFQSSLPSPKLQLYVQEPVSENLSTLLRSESEVDKGRRESALQSFSTNGDSPANRTWLRTSHPPTTGGLANNRVQGSPSGYCIKPGQNPGAASSDDGSSIPSRWITAERCAELIKSKSQKVLLLDVRPYAHFSQSNITGSLNLCIPTTLLKRRSFDTQKLEKTFTSDDDKGNFARWRECTTIIVYDSATSDVKDAVPLGHVITKFQAENWEGEGLILQGGFKAFSSQYPQLVRRPQAQTAGPSPKKKRSPMSIDLNSIAPVVGGCALPASSSAANPFFGNIRQNMDLMGGVGQIPLKLPDGLTETQRQELPPWLREASDVKDQGHRLSEKFLDLEKRELERMKQALTYEGSSASTGGATKKYRVAGIEKGTKNRYNDIYPFDHSRVRLEGIPSGGCDYVNANHIQAEFSNRRYIATQAPVPDTFNDFWRVVWEQDVRLLVSLTAEVERGQTKCHPYWKSGDYGPFKVKAYSERFINVDTKDRSIDPTAKSPLGSSQQAQRTDESNENPVIIVRHFSLYHTAFPFQPLRDITQLQYPYWPDFGTTSQPAHLLNLIEQCNKVIRSTSTSKFGNQDAEPKGQRPVLVHCSAGCGRTGTFCTVDSVLDMLKRQRMSSEDSNFDALQNPSLDLIVKTVEDFRTQRPSMVQNLSQFVLCYESVLEWLVSRMDDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGU1</accession>
    <name>A0A1Q5TGU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposon Tf2-1 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8428</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000657">
        <property type="protein sequence ID" value="OKO99444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="241"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="755" mass="86997" checksum="A04BD16B9AFD816E" modified="2017-04-12" version="1">MLEQQASPAATTTTTNEEQATPARSAAESVPIPPRTETIHRPKPRLPDPKPFGGSTSDWPTWRISIENKLSVDGEAIGSPQDQFIYVFSRLEKLAWKNTGTFVKLRRNTGEPQALLDFLESIYGDPNIKARAARRLHQIRQPEDMSFSRFLPRLEKEFADADALEWHDEAKRQILLSALNKTMTNAQQLADQLPPHRPGIDHKIPLKRDRNGVEEPPPYGPLYGMNKEELLYLRKTLTDLLGKNFIRVSQSPAAAPILLVRKPGGGVRFCVDYRGLNERTVKDRYPLPLIRETLRNMGHARWFTKLDIIAAFHKIRVHPGEEWKTAFRTRYGLYEWNVTPFGLTGAPATFQRYINQTLREYLDDFVSAYVDDIIIYTNGTLADHRRKVGDVLQKLMDAGLQCDIAKSEFEQESVKYLGFIVEAGKGIHVDPKKVEAIRAWERPKSIRDVRSFIGFANFYRPFIPRFADLSAPLTRLMKKDAFFKWDDDCQLAFIELKELFINAPILAHFEEDRQTVVETDASGWATGAVLSQYGPDGQLRPCAYLSQKLSPAESNYEIHDKELLAIIRALREWRPELKMVPRFTIVTDHKNLRYFGKAQHLNERQMRWADLLTEFDFDLRYRPGKLAVRPDALSRRSQDMPQSITDERLSNRFRVLLKRVKVKTGRLDPRSADDQSNEEIDFERNIPLFEEEELQVEWKRARASDSIYQRITHALLTGERRIAAETNIKTSLSDESGPKYQWTLSQSCHPLDPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI93</accession>
    <name>A0A1Q5TI93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI93"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI93"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="74"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="35103" checksum="10DF2AA8D771DA5F" modified="2017-04-12" version="1">MSSKLIVLPRPGATQSNDIIQPIQAPSEAAFVATFGQLLPPASYLQTPHGRAAYYELPASSPAPSDSSNPISRVLFVHGVQTSALGMQPLASALSSRFPHAHCVLVDQWGHGLTDTPIAPHEPALFHALLEDLMVHLGWEDAHLIGYSFGGSTTATFAVAHPERVASMVLVAPAGLLYTSEFTDVQRSYLRGGEGSEEQARAWIFEFLEGGKLVVPSDWKERVGRGEVVAEAIREWEMKEHDGHSASVVAIIRDGGVLDNDAEFAKAAKSGIPNLSVLGELDGAVSVEKLERVGMRNIAVVPQVGHGVVRERVPEVAGLIEDFWKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJN2</accession>
    <name>A0A1Q5TJN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="208" mass="23311" checksum="B8FEDE4183FCD3DC" modified="2017-04-12" version="1">MTEGIVLQSAGVSQMAREYPRRNNTIECSGAAVVPEKAAQVLNSEDTDIPLNQKHDSGAVVFLFPPNGHLPWSLSTTWLACKMWILEMFKPVKDNSCKDERVDKLMARHTSGKKALQARYPKLWYLEVIAVHPSLQSRGLGGAVMRAILEQVAGNPIFLECTRQENIGFYEGFGFKTIEEVELTDNPAHANEDGKLKYWVMVRETDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKP7</accession>
    <name>A0A1Q5TKP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Septation protein imp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_7725</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKP7"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="863"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP00794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="923" mass="100575" checksum="18D78FAC8FAF6BE8" modified="2017-04-12" version="1">MPGTVAEGPSVSMSFANNFWGKDDAGLQPMLDRMHASKVTSDELKAFYSVRAAIEDEYARKLQALCRKSLGSAESGSLRSSLDVVRGETESIAKAHAAIASQMKTELEEPLTAFSKGIKERRKIIQDGIERLHKNKMQQTQLVNKTRDRFEQDCLRIKGYLAQGHMVMGQEERKNKAKLEKTQIQLASNSNEYEAAVKSLEETTGRWNKEWKAACDKFQDLEEERLDFTKSSLWTYANIASTVCVSDDASCEKIRLSLENCEVEKDIVFFIKERGTGQEIPDAPRFINFCKEDEDVSDIEDGEGYSVAQFQRAMNPAFRTSSPQPSTFESHHDPDSELAAQMGHPTQMGQPVQMSQPIQAPAPAPAPAPVPIAQPPAPLDLRRGGQLPPNYDPEQHGEINRVPHNAYPTDGMTMFCRTGPPSERSSASAYRPSSRDSQSEVSNLSNPTSMSSVEAPITVHKSPPKATNSAPLPSQNDDKSVQKKKSAFFSNSPFRRKSRHDKERPAIGGQSSSRSPWSSPTKSASPTKPAPQAQPERHSPEPVDPRANFQLNVGNNVFDVASPDKNAKAGQQAKAGEDDTDPIARALADLKTGGGKQSTLRVSADRYHGIQTPNPSAPSSAYGGSSSGAPPAYNDPSVKRLDAPEPAFTSKQMQKTTQRYTGQTQSMLRNGANSPSMAPAARTPSVAAPAVRNEVPRARSPDPRRSASPLVSSPRVDTRMGGQYSGSASPAPQSPAAYQSSSVRSRYSQSPTPHRAQDPPYSPNDYARRASPAASTRAVSPQPQFRQQVRPSSAGGMELQLSNGHPDMYGGGAREGYGSRRGDGRPMSQYGDNVNTPPPVGRSRSRTLAVAEPGRKFSRDGRPILHFARAMYSYTAAITEELGFTKGDVLAVIRLQDDGWWEAEVTNSRGHPGLVPSNYLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL14</accession>
    <name>A0A1Q5TL14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metal resistance protein YCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TL14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004222">
        <property type="entry name" value="Os02g0288700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1200"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="306"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="626"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="973"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1291"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="853"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="912"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP00906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1543" mass="172204" checksum="1F677D9B7CB21FC5" modified="2017-04-12" version="1">MLDGHTQMVLGDSQSGDLSPSQLTSAFDHRQRQPFCGDSEGWGPLSLNGFYLTSCFVDVVVAIVAVWGSLAGLAALWMLLKKRIPQPVSKNWHFYAKLVVLAGLIFVTALEPALHAETQRKTFYADFRFWSSVATLASLGVIFTVQFYEHWRSRQPNGVVLFYWLFFIIAYAIKLQSHVAQKTYLHHLPYFVCVNVSLGLSLLEFSLEYFVPKKQSAYDALGDEDECPYNYADIFSVLTFGWMTPMMKFGYKNYLTQDDLWNLRRRDTTRVTHDDLNAAWEAELEKKSPSLWVALFKAFGGPYVRGAIIKSGSDMLAFVQPQLLRYLIAFIDSYRSPDPQPVIRGVAIALAMFVVSVVQTSCLHQYFQRAFDTGMRVKSALTALIYAKALRLSSEGRATKTTGDIVNHMAVDQQRLSDLTQFGTQLLSAPFQITLCMLSLYQLVGPSMFAGVGMMILMIPLNGVIARMMKKLQIIQMKNKDSRTRLMTEILNNMKSIKLYAWNTAFMNKLSHIRNDLELNTLRKIGATQSIANFTWQSTPFLVSCSTFTVFVLTSDKPLTTEIVFPALTLFNLLTFPLSILPMVITSVIESTVAVKRLVEYFTAEELQTDSVNFQDPVEHAGDESVRIRDASFTWDRHSGIPVLENIYLSARKGELSCIVGRVGAGKSSLLQSILGELWKNQGEVVVRGRVAYVAQTPWVMNASVRENIVFGHRWDPAFYDLTVEACALVDDFKIMPDGDQTEVGERGISLSGGQKARLTLARAVYARADIYLLDDVLSAVDQHVGRHIINKVLGSSGILSGKTRILATNAITVLKEADFIGLIRDKTIIEKGTYEQLMAMKGEISNLVRTNLAESDEERSPSISDDGLASPNTSEDTAVIETGEGSDSEELEEPGSLVPIKSHGDTRRRTSTVTLRRASTATWQGPRRKLGDEENVLKSKQTQEIAQQGKVKWGVYGEYAKNSNVVAVSFYLFALLASQTAQVLANYWLKNWTDYNEAHGRNESVGKFIGVYLAFGLGSSLLVIMQNLILWIFCSIEASRKLHERMAYAIFRSPMNFFETTPSGRILNRFSSDIYRVDEVLARTFNMLFTNSARAVFTMIVISSATPAFLLFIIPLAWVYLSYQKYYLRTSRELKRLDSVTRSPIYAHFQESLGGISTIRAYRQENRFALENEWRMDANLRAYFPSISANRWLAVRLEFIGSIIILASAGLAIVSVATGIRLSPGIVGLSMSYALQITQSLNWIVRQTVEVETNIVSVERVLEYANLPSEAPDVIFKRRPAVGWPAQGAVSFKNYSTRYREGLDLVLKDINLDIKPHEKIGVVGRTGAGKSSLTLALFRIIEPSGGTISIDGLDVSSIGLLDLRGRLAIIPQDPAMFEGTLRDNLDPRHAHDDTELWSVLDHAKLKDHVTSMEGQLDAQIQEAGSNLSQGQRQLVSLARALLTPSNILVLDEATAAVDVETDALLQRTLRSSIFQDRTIITIAHRINTIIDSDRIVVLDKGRVAEFDTPANLIKQGGRFYELAKEAGLLDSDGLASSSSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMJ9</accession>
    <name>A0A1Q5TMJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_7440</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMJ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMJ9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011814091" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP01450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="612" mass="68469" checksum="A94C8DED93233533" modified="2017-04-12" version="1">MLSWSLSLLLAPALAAASSAADYYVHSLPGAPEGPLLKMHAGHIEVDPENNGNLFFWHYQNRHIANRQRTVIWLNGGPGCSSMDGALMEVGPYRLKDDHTLEYNKGSWDEFANLLFVDQPIGTGFSYVNTNSYIHELPEMSAQFMVFLEKFFQLFPEYERDDIYIAGESYAGMYIPHIATAIQMRNKAAEQEGKTKWPLKGVLIGNGWISPYDQSPAYFEFAQRMGLINEGTQSYREIDALNSICLAALEDPRSKEMVNIRQCEEVLQGLTRLTTKDGKCVNTYDIRLQDTYPECGMNWPPDLANITPYLRRQDVRQALNINPAKTAGWTECNSAVSQTFLATHSIPGVKLLPALLESDVNVLLFSGDQDLICNHLGTETLIHNMKWKGATGFETDPGVWAPRHDWTFEGEPAGIYQYARNLTYVLFYNSSHMVPFDQPRQTRDMLDRFMRVDIASIGGRPADSRIDGEKLPQTSVGGHPNSTAAEEQENKKLKETEMHAYTKSGEAILVVVIIGVTVWGFFIWRSRRSHKGYRGVKNPDLRGGSSVLDRFHNKRSAADVEAGDFDESELDALHSPGLDREHYVVGDDLSGDEDEGAGKNGNHRQPSASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ15</accession>
    <name>A0A1Q5TQ15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ15"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ15"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="177"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="756" mass="86932" checksum="E2E14342603BBCED" modified="2017-04-12" version="1">MIQRSRAVFEPFPPHLDIEEEVRTTKKFEFAKKISFDSIAQFPREVLELYILTHVVKLGLPLVITGFDKHLDKDLFSEKWLRRHYASQTYDARDLGKAANMRLTLGHYLKNMSTLTELVSPTTYNRPNIQRLYLKDIDCPDEWHKSLEEVIPSSFFYLNQSPLKGPRSPASQFPDPPKTPQGQSVARSGDLMSSLPEAMRAQNLMCYIGHEGTYTPAHQEMCASLGQNLMVEASDGSFEHGKPTRPGSSIWLMTGTQERLMVAEYWTSMLGHNLDLENHFAQLNAWKSAPFTTYVVEQRPGDLILVPPLAAHQVWNRGTRTMKVAWNRITVETLEMAFDEALANARMICRDEQYKNKAIVYYTLDRYSDLLRKASKSSHPEVRMLQEDFHRLFNIYTDILLSETFSKNSPAAKEIEFEKFESNITCSYCRCNIFNRFLTCPWCVGEGNDTYDICMDCYVLGRSCQCISKLKWVEQFPWKQLTGKHETWRQQILAFKQDDRDPKLKGPPTLLVARSKLGRKSLAEICQEQMRLRPWVDYKKPKEIKAATPSDDEGSDSESRARKRRKSNGNKAPSGKGRCHMCKSSECLWKLAACEKCNLYYCYGSLFRAFDMLPQDAMQKPHWLCPKCRKICNCSSCRQDDNMKPHQPFNILLGHDTRKIADPRSVESLVNMRLSNLALLKTFGDDNADRLERLRCDEEKRRQQQQQQLADNDIHVGLDSPHSEPVIDNPVVDDSQLPGIPIDPALELDGSFMNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRJ4</accession>
    <name>A0A1Q5TRJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="27503" checksum="3F33CCBED245736A" modified="2017-04-12" version="1">MATEAALASFDVRADVDFMTLDYLACFALDIILAAAGTANPSPELEDEVKWTASLVEKQPIPLELDVKLRVFALAHDLWNYPDPQTTATPASASAATNNSPALARIGIDFLRMCQVAAHRVSETRWFDVGGRFMIQSALLGVRQGVPVSLRQFSTWTPDTPERRSKWWDVRESYAAEIPDDLGDRAAWVTLDQQYPFAHFKAIVVEFLFELMTTLDAPILLQLERGKLDGWTPEETQQLMKEAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRL8</accession>
    <name>A0A1Q5TRL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRL8"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="9">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP02873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="16768" checksum="FB0911453C76A620" modified="2017-04-12" version="1">MPTRLSKTRKHRGHVSAGYGRVGKHRKSPGGRGMAGGQHHHRTNIDKFHPGYFGKVGMRYFHKTQQKFWKPTINLDKLWTLVPAEKRDAYLSGEKTDTAPVIDLLPLGYSKVLGKGRLPQIPLVVRARYFSRDAEQKIKEAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRP1</accession>
    <name>A0A1Q5TRP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">White collar 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_6961</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRP1"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000065">
        <property type="entry name" value="GATA transcription factor LreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="479"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="610"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="845"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="659"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="724"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP02889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="908" mass="99276" checksum="6D815B0E8C35C03E" modified="2017-04-12" version="1">MANPMNNFDLEYSAATRDDDSPDAQEGVPSHLRSSLSDPSLMGYPNSHVASYPFADMLPQDFDSTLQSFDQNPRAQGELEGRLSNVMLAYDAPTTGVSMTMGLDSSGAFAFDIPTTYPATTMSLVPSMDDSQLQSAFSFHQSMSQAGQYMPQQQAPPLQQARRDPYNGHATNTTTTSTETFEDSDFSRASDRSQQLNLRPVQESQQFSSYGQTQPTGLAPYRGTQPVAIQPKKAIAAVKDDLSPGLSTPDAASTEHTGIYSSSGFDILGVLSRVAMRPNPKINIGAVDLSCAFVLCDITREDHPIVYVSDAFERLTGYTKAEIVGRNCRFLQGPDGQIIPGAKRAFVDGQTVHRLRSTIHDRSEIQASIINYRKGGQPFMNLITMIPIQWNSEDYRFYVGFQVDLVEKPDAVQARNPDGTYSINYQRDQLPQYVVPPAEAYRLRPDLATQFGHDEVTAILNAVGVPGSGVSRHYLDRILVENTDDVIHVMSFNCEFLYISPSCKRILEYDPVELVGKTLSTICHPSDIGPVIRDLRASTTPAPVSVVYRIRQKYKGYMWFESHGAWHIDPSQGRKYMVMTGRPRAVYSLEQVAQLGSKAALAENDIWAKVSLSGVILFVTSKVKPVLGRSPDDLIGKSMHELMDPDNDPNAITDALDAAANGQGHDDGSSKSGEPPSFRHQMRHKKGHYLSAHTTLYCGDSHNARPSFLVAQIRLARAFPPSSAAASAAEDEELANVPGSSKTTTLTTSDPNPPSQYGALGQRMPFLSTLIGLNGLPTGNRSISPSDAPATFFTELNPTRGSSWQIELRELEKQNRVLADELQRLLARRKKRKRKQSTISVEKACAMCSTKNTPEWRRGPSGNRDLCNSCGLRWAKQVRNKAQAAASGNGAVPTTSAAAAAATATTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU74</accession>
    <name>A0A1Q5TU74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromosome transmission fidelity protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU74"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37717" checksum="82F32B931606B0E1" modified="2017-04-12" version="1">MPKLPSHSRSLRLALQPSRAAGRSVTSSPRRTLAHPRHGILNDPWLPAPSTVPLPTAYFSPTGVRKDLNGLGGGPGNNDHKPPDERVLKLGKTLRTLSPLLPTILYNTLPPEILAPSVNLHLFPSTHPHLPTVKGRTLYRAALWTVPVAWSSVPLVGNVKLQILSERIVRAGTILDPKHEDQHDCGDERLVVRWRTEPRTDSRPFHDVKKSSGAQSDSSGSSQTSKAGAGLTPGQSHLSSSKNGTNRGLSVLLGGEEPIFKLSKEGQFTGLFIFSFDEKGRILTHTIEHADEAEGWDRTSKFVTLTDWLIGKARESLDPTPNPGLAISCENYGSAPSHADYHCRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0F5</accession>
    <name>A0A1Q5U0F5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0F5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0F5"/>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="742" mass="81637" checksum="CCB6285CAF6EBC6B" modified="2017-04-12" version="1">MARATTAVKSRTAPDTDAISFPVLTYTDALPRADLRDIKNNGSRQLPEHGKAAQYEFPRPRHMDGQGSRKPPNNVAMAASFDFRVTAPPDEVFPSRAGADGSPGGIPRIGVALGSPSMLDSRDNLPPPRFKTDIFSQEKDGQPPLPHKPSKWRKIGGLFKAKYALAMPMDGPKVPPKPAPKPESEQSNKPLQRRGSIEEWPMIEVDSTAAPAGTNSSPQRSRKLSLPGRKANKPQVPEKGEKSRLLEIDIPDVQMERYSVMFSQVMKKNQRPSLLARRSKTLDNLRMPNNEVFLAAKPPPVPQRRATSPARSSFTLFPASQPSKATQVLGTQQNFSRGPSPLLRSNTLPVESPSKASMDQGRATPNINVASPFESPVVPNIFSSQSSTPRSSLDKPLPAIKPELKAPQSRPRMASKLAVAHTGKEPSQVKKEEVEERPQTAKQPAVTPNIQVSESPRRSPSPQSEAKPSAPPVNTRRRSASLALPRSRTDSQVEQKPIQPIPALRPRPSQLPISQTQPTYQERKSSLQAPRMHTRPPIQEPPMPHLTPQKAPNLVQEKEQRPQQRPDMRPPRPNLKIQTKQQQQPPPRPAAKKGSSSSTLPTSTPPTSTLPTPNLSKDNLYRTPSPIIRSLSPQPGISPGGSSPRMPFVSEPEEIDIEIGMALETKEPTESLRKIPTIEVSIARSISVSRGKRQMIVPVGARVDYLHSNERLIERRPMTPRITDVSFGHKHAVSQELQIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Z6</accession>
    <name>A0A1Q5U1Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4-coumarate--CoA ligase-like 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Z6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1Z6"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="463"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="561" mass="62304" checksum="0C921A84E9BDFDD9" modified="2017-04-12" version="1">MPYKSRWQINVPNTHLASLLLTSPTAPLSQTKRCYLEAARPDTHYFTPHDFRLWSQRFAAGLRKAGLKPGDRVLLFSGNDLFFPVVFMGIIMAGGIFTGANPTYVARELAFQLEDSGAKFLICAAASLDTGIEAARMAGMPRDKVFVFDNAIYDGQGQGQKGCAYWGELVASAEEGRGFTWEELNTPALADTTLALNYSSGTTGRPKGVEITHKNYVSNMLQYTHMGTLYPDYEERRARARWLCFLPMYHAMAQNIFIAAALYRQTPVYIMPKFDFIRMLEYTQKFRITDFILVPPVVVALAKHPAVKNYDLSSVESVGSGAAPLGREVCVEVEKLWPEGKINIKQGWGMTESTCSILGWDPREKSFSASVGELNANCEAKIVADDGVTEILERNQRGELWVRAQNVMKGYWHNPKATKETKTEDGWLRTGDIAYVDDKGKFHVVDRMKELIKVKGNQVAPAELEALLLEHPAVADVAVIGVTINNDERPRAYIVLKPGQSATADDIVHFMDGKVSATKRITGGVVFRDVIPKNPSGKILRKVLREQAVVELKQGSVSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4L5</accession>
    <name>A0A1Q5U4L5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4L5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4L5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="77" mass="8872" checksum="01CF1CE90F9967DF" modified="2017-04-12" version="1">MFLALIEITERFYLLDLVCGLLDGLWRFVDGRRHCLASEAFWKDSLIEAGFDQVAFTKVRVAGRKRNPQVIVAWNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4U7</accession>
    <name>A0A1Q5U4U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4U7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4U7"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="777"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="860" mass="95694" checksum="C61B66CB1F86EC62" modified="2017-04-12" version="1">MTPTPPSTTSSSAGAHSPEFRVIRKRNRVPLSCAPCRHRKLKCNRSHPCENCVKRGDAASCNYAQASSRKKNSPQQTSPTSPDDMQNRIDRLEGLVLSLMTNGNQAAGPAAALAAISGESSAGSTGLSNEIDIDDIDDDAEGGPEESDTEQVTKSFGVMKMDSGKSYYISEAHWASVLNDISEVRNFFTTHKKQFDDQAEKLKATRPETDNPGGSTLLFGAMKPLTRPEILASLPSKYTTDILVARYFNSYDPATHVLHGPTFQAQYNKHWEDPTKTELVWIAMLFAMMRLSMLSYHREGDEPPEFRGKAMDMAGSFRNSVAQCLTLADYTKPHRFLIETLVFHLYGDFSQTRDADISIWVLSGVIARLAMRMGYHRDSKMFPNITPFQGEMRRRVWAFVRQADLLFSFQVGMPSMLRTTDSDTDLPRNLYDDDFDEDSKELPPARQISEPTPISYLITKARLTYAFGRVNEHYSAVSSSSYDKVMEIDADLRRGRDLIPDHLQIRPLDECQLDPINLIMSRFSVMTVYHKAQCVLHRPYLIRARENPRFTYSRRTCIDSALEILVFQAILHAETRNGRLRGRTVVTSLTSADYLLAATIVCLDLYQTFQLQASNRPSGDTYTWGHERREEMTGAIQRSKEIWDQLRDESMEAFKASSVLGVMLNKIHSAVPPLENTSGTGGAIFETQDEKQNAAMTLGLLSSGMSPMSQGPPPFTDPLFKMSDASMPSSMPGPTAEMPGPLSPFSSMFGTMPDMQVNLDWDAWDTYIQNPTFDTSNQFWPMMDPQRQQTPQGVGMTQPPMTSPLGTTRTSSMSNGAPSQRLPNIFSPPGPSPESVTSSVPGFTPMSSQSGNSGRSQGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5E8</accession>
    <name>A0A1Q5U5E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5E8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5E8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="400" mass="44021" checksum="7B26B322C4E179FD" modified="2017-04-12" version="1">MKRASSLGIDAFALNIGLDPYSDQQLQLAYASAARNSMKVFLSFDFNWWHKGPVQEIGQKIAQYASLSAQLMIDDKIFVSTFAGDDLDVAALWASVGKPIFFAPNFHPSYGTNTSVSAVDGLLNWMAWPDNGRNKAPTSTQNISVADGDRAYINALGGKAYVARPRFVEIVTWNDYGESHYIGPLQSQHTDDGASKWVNDMPHDGWLDMAKPFIAASKAGTSSLTIKSDQLIYWYRPARRDVNCDSTDICMVSANNASGNYFLGRPDGWEPMEDSVFVVSLRTAPTSVHVNSGGIVYIYEAPAGASVQAIPMNVGVQSFSISRNGQVVLSDTSLKPIINICVCGLYNFNAYGLACTNLRGITITRNGTSYGQYYLDNDDFCLYNIGHVCHYVQRDDIYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5W9</accession>
    <name>A0A1Q5U5W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Extracellular exo-inulinase inuE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5W9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5W9"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051670">
        <property type="term" value="F:inulinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000003">
        <property type="entry name" value="Extracellular exo-inulinase inuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012072733" evidence="6">
        <location>
            <begin position="21"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="448"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="548"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="704" mass="76733" checksum="AA75F48C82C2E4B2" modified="2017-04-12" version="1">MVIMLKALLLGLSAFQAVSAEKPSYTELYRPQFHFTPSKNWMNDPSGLLYHEGIYHLFYQYNPGGATWGAMSWGHATSRDLTHWEQQPVALLARGYPNNITEMFFTGSAVVDVDNTSGFGHSGKTPLVAMYTSYYPYAQTMPSGKTVQANQQAQSIAYSLDNGMTWTTYDAANPVISDPPAPYSDQFLNFRDPNIFWHKPTKKWIAVLSLAELHKLLIYTSKDLKNWTLASEFGPVNAVGGVWECPNLFPLSVDGDDDNLKWVAMIGLNPGGPPGTIGSGTQYVVGNFDGTTFTAEADSLYSGTTPPPSDSIVFADFEGTGSFADLGWTPAGDLIGQSPVNGTLRGQNPVTGYLGKRLVNTFLNGDATTGTLTSRSFTISKRYINFLIGGGHDFNNTAVHLKVDGQIVRSATGTNSESLSWQSWDVGSLLNQTAVIQIVDTSSGGWGHINVDEISFSDSMARSQVANWVDWGPDFYAAQSYNGLPPDEHIAIAWMNNWQYAGVIPTSPWRSATSIPREFSLKTIDGKATLVQAPTEKWGSIVRRKALDRSWSSLNQGTKSLGSVGKALQIELSFSDREPAAAEASQFGIIVRATPDLKQQTRVGYDFSTKEIFVDRSQSGDVSFDGTFPATYYAPLAATAKGQINLRIYVDWSSVEVFGGEGETTMTAQIFPSDSAAHAQIFSTGGNTQNVRIRINEISSAWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9Y0</accession>
    <name>A0A1Q5U9Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9Y0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="28006" checksum="84A1B3C81BECABD5" modified="2017-04-12" version="1">MTIEMPELEQLTVDEFAGEIIKQPSAGHDGDISRARCILTLPDELLSKILDYSILFQPMNSWSESPLRSGYDPARIMTVALTCRRFSQIVVPFYYRKTFSDYVMKLIPPDSRLELLLCTLQANPSLGLHCRVLNSFLPDKGNHEEPGGGCGLAEQLPALVPNIKRVYLRGCFGKARNKQAWTFLTACVRHMHQLEDVALQRQAREGLEVADFLAAFQGSSLKELRVGGFAKSRSRLEDLKVGRIDRLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAY5</accession>
    <name>A0A1Q5UAY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAY5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39411" checksum="CCDEB36481FC07A9" modified="2017-04-12" version="1">MFKVRRATEYLETHLQTHNAEESWRTWAQSEEQTRLAAGLHILDTEISELVLTHPLLQHEESLLPLTTSHELWVAPNAAQWKTILARQQGGSGLDQDNSNGIVAGRGTLPPGTGLPGGFQRYITLEGINARIAETRSSHAARDQTVCAQFESQLMQFSDQYFHAKTDITAHDPFCLEVLWHSAFISLLVDFDRLELAIGREGYEESLLYRNYAHQWASSPNARRCALHGSMILRKLQNTPLGTEPAIHVPRALYRAATVWYAYSEYGLDVDPSSPETPPAVNVEFPEFSRLKINSQALLFEANGYRTSRPKTSESSTLCGLVDLLHRIGHWGLSRKFAEQLSFLLKETQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB73</accession>
    <name>A0A1Q5UB73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="29237" checksum="EA3258DC1A1E16BF" modified="2017-04-12" version="1">MSSLSLKNFAFGALSLTVMQNYLVLSGGFGSSPYVRQRLVESLTLRGPDGNLDADGMHILVADEPQLVVVHGLVLDRIQKIKSDVVTFGSRCAPVSYGIICDKIYHPEKHIGEAVRHDPRDKMTYAIDQIDWLVIQGRPIPSTGLTKQFQLKIDPGRESEPWRVSIVMSTLPPDQIPHNLSSKGAQRICDLDISTDSVDKKLKNRHWYSMKPAFWRSTFDVRVVVGPADLSFQLWSRDKRIQASKHEPIAVNWMPASNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBR0</accession>
    <name>A0A1Q5UBR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000436">
        <property type="protein sequence ID" value="OKP09903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBR0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="179" mass="20961" checksum="EF77F171D6E57DCB" modified="2017-04-12" version="1" fragment="single">GPLPEIRDRTQKSYTQFSDYALFTAYLQEVENSIPTRAKVLGRRKNCSVSNDEHFLPTDNYEHNQKDSPPSQPPTQPAQQTRALPPAEPRSKLEYRPSPDAPDLPFYSARSWRQCKTFMSKLQDHFHKCGDQCKDFRKIEIARANLSRALLERWDEYAACLKNCYLVRILRFPRRPNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBX5</accession>
    <name>A0A1Q5UBX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000419">
        <property type="protein sequence ID" value="OKP09982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBX5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="191"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="550" mass="61501" checksum="878F5A61259D1E8D" modified="2017-04-12" version="1" fragment="single">MCARPCHSSYDTTTCYRCRHAAPWRTAASSTESGTLRALLPAGPVLEPGFQPRLPSPITPQKRSNPPPLRPTVKRQGTLAQPSFQDSLDRALSFLRDELEGRAVASDAFPPDVSCSHIRTSIARYEDEISAAAKRRVCCSCGKYVPITDTYHVDIEDPLLLLLEGTLDNCGRHGDTWDLCSSCHDSLNRDVIPKFSAKNLVNVTLCQNFPLALEGLTLTEECLIAKCHPLGVVLKLRPGGHASSVSYHALRGHFIVIPQDPGPLLDILPSPELTLHSLIKVFWLGTRPPVDSDLNPFLLVRKAKVLAALQYLVQHNRLYRKLTINRPMIDDSADDFIPPELQDNIIFLDESDHHEREGCTVNLQMGNYENDLQAAQDGAVDTSSGEPLFTCSVSTDINGERYDPNLRALDALFSVATNRPAPSREDMSVRESERNTQPFNHRQMPTISYTTRGDATLLDYWTDPQYFTAAFPTLFPTGIGGHLDERSIPVSLTAFANWALRHHSRRFARHKTFMYLLYDVVQLRRSSMGNTLLIKRQNWQSTMNDIASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC13</accession>
    <name>A0A1Q5UC13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4426</name>
        <name evidence="3" type="ORF">PENSUB_4593</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000412">
        <property type="protein sequence ID" value="OKP10003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000381">
        <property type="protein sequence ID" value="OKP10163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="179" mass="20304" checksum="C8A52CC2AFFF3347" modified="2017-04-12" version="1">MAAIIASHLEKRSMFNDQPWVTEHSALRFAICLSGFRLGPIYDKFYEPTIRTPILLAIGSYDTVITAEDSHSLAKHCQFARIFEFSGVHYVPQFKESRDFRKTLNDFLEEFLFDPPAQQAPRLSTQAGAIVRSPFNTRPFLRTYRRRREIAVASGFTKRWAISALGNQVAANSITSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCD4</accession>
    <name>A0A1Q5UCD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCD4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021276">
        <property type="entry name" value="DUF2855"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11017">
        <property type="entry name" value="DUF2855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="24327" checksum="9EE86A0438852437" modified="2017-04-12" version="1">MSGIKTWTSLSSLVDAKELKRMSWVSLFRPTWQTGYLLSHHTFTSDTTSRSPIHPLGIDLPWTPADADISAAVVISLSAAGKTARAFAYHMFWRNAAKEGPIWFLQISQTPELLESVPRILGTDIPTKAVRYDLVGGSAELIEGLDPKRIVLVDFGGRAGTLAQLIESIKSHSALGEVQTTIIHVGSEQNVYSADEIKGNCQTMQTVGEVQFNTCGVRDAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCE6</accession>
    <name>A0A1Q5UCE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCE6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052969">
        <property type="entry name" value="Thr-specific_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47763">
        <property type="entry name" value="ALPHA-PROTEIN KINASE VWKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="84"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="40240" checksum="604690AC21E250BF" modified="2017-04-12" version="1">MNSDESSDSRSARIFIIWPPAPKLLASCTGPPRWSLSLVSALVGRALATTPGVSPASVSRSQNPGTSFNIQKTINTPEIPPTPDIVLLVDKTGSMGGAIADIRTNLKNVISSITSSQPTAEFAVVEFGDDRGASSVQFWVDIGLSSDVTALQNAVNGLTAGGFGDTPEDWINALYQIASGDISFRSGSSRVVVRVGDAPSHDPSGGHTLNDAISALKAANIRVIAVDVGYNYPPSPGKGAIDTNGQASSVTSATGGSLLPVGSGASGVTDAITNGLYDFPPHELYSAEWHCRHLHRDGERGQQCSERRHDKLLRWLLSERCAGAKFGPYPTSTNIKLVQAPGATPKAVPGEGAVTWQIRVKGCAQLITTDDAGNNATPINCCARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCG8</accession>
    <name>A0A1Q5UCG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyltransferase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCG8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCG8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16147" checksum="427358B66435DBC3" modified="2017-04-12" version="1">MPRSEEAEAWANAVYAAIQEIPRGKVTSYGHIALLLGEPQRPRQVGVCLKSLPNAESGSHFHSGNVPWQRVINSKGMISHREYRGPGSAERQAEALIQEGVEVTRDSMGEFYVNFSHYGWFPKMLPSEEEEGKNDGDGELFVQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCP1</accession>
    <name>A0A1Q5UCP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCP1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF2">
        <property type="entry name" value="PROTEIN CON-6, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03615)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9631" checksum="8BCAD39366A19458" modified="2017-04-12" version="1">MGRNSGGSQENKLRGYKAATHNPRVSEQARAHAQQEADKMSNYGSDEERHEENVKRGLKAAMHNPRVSEGGRRGAKDKLNEMGEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEV3</accession>
    <name>A0A1Q5UEV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein HOL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEV3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEV3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="325" mass="36286" checksum="34658EEA5E5C2BF5" modified="2017-04-12" version="1">MSMGSSLGPTFAGIIADHLHDWRWLFRITSILLGANLLSCLAMLPETHHNHRDPSQESQSLEQGKSNEESDHCNTVEHVDEVPQRQPLIHLWFERSFYVPQTVKSYKPYFQYLLDLLLLLITPEIIVTVLMWACTIGWVLVASIMSAIYYGSPPFSWSSQEIGLLNLGPFVGLVLGFPLGGPVADKVILYIAKNKEDPDPRGRLVLLLIGGIISPLGCLLMGLSLQNQWHWMGFAAGWGMLAFGITSSCSILLTYSIDRFKQKAGHVGLVVQMITYLLSFAMTYCTVDWYTAQGALKQFGTMAGILWVCYLLGFCLYYIPLGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF67</accession>
    <name>A0A1Q5UF67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF67"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011812380" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="28"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="562" mass="61122" checksum="FE2FC2B0BE02CA6A" modified="2017-04-12" version="1">MKLYSFILGAFLPLVVLSSPARRAAEPTVTISSPIATIVGQSSDGLESFDGIPFAIPPTGTLRLKPPHPIETKLGTIQATGTPRSCPQFYASSESKDILVSLVGETFNLPFFQEVTDAGEDCLTLNIVRPEGTTSESRLPVLFWIYGGGFEFGSTAMYDGSSLVSSAIDTNMPMIFVAVNYRLGGFGFMPGKEILQDGSANLGLLDQRLGLQWVADNIEAFGGDPDKVTIWGESAGSISVFDQMALYDGNNTYNGKSLFRGAIMNSGSVVPAERVDGIKGQAVYDSVVAAAGCTSANDTLACLRALDYTTFLNAANSVPAFLSYSGVALSYLPRPDGIILSDSPDKLAKAGKYADVPFIIGDQEDEGTLLALFQSNITTTEEIAEYLKEYYFYNATSDQIDGLIAHYPDTATDGSPFRTGNLNNWYPQYKRLAAILGDLTFTLTRRALLEYSTQVKPNITTWSYLASYDYGTPFLGSFHAGDILQVFYGILPNYAVSAIRSYYFSFVQNLDPNAAVSYSTWSQWSENQTLMQFFADSSANLADDFRSDSYDFLLANAEAFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG01</accession>
    <name>A0A1Q5UG01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8277" checksum="D4D9EC1336F00BE0" modified="2017-04-12" version="1">MSIPEPSSSSSHNPAGSSLSQNNVSQVPRSNQNSVNRFARAPAADGPYYAGARMGERSTHMNGLSNQVNAMDDILKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG44</accession>
    <name>A0A1Q5UG44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG44"/>
    <dbReference type="OrthoDB" id="4477787at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202788" evidence="1">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="201" mass="22871" checksum="CD6B27FEFF425BA4" modified="2017-04-12" version="1">MRVSLDRILLLLFLALTPANAIGLSCIKVASALVGRPGHLFNLFQTEICERGCQPTIPHWDLWTRNNSFVPAVRSLMKRMNVPHREEALLKMGDDVATIIKDQCGPMLGGRHICSDPVTLADFGNCFKRYFFKASVKHIPILLPMASEAACKEQYQYLQGDELWDVTIPNNMREYASVCNQLEKKPRLEENTEEEVKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGT0</accession>
    <name>A0A1Q5UGT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGT0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGT0"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000167">
        <property type="entry name" value="Uncharacterized mitochondrial carrier C29A3.11c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="125"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="239"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="35429" checksum="BFE52D01EE7E6AEF" modified="2017-04-12" version="1">MPTRNAWIMDESTRNRLLKKYKTQVASATSTVCATLAVTPLENVKTRMQTHNFRDIFQCARYLWRTEGPRGYVAGALPPLASVTAVRVLNFTSYNYAKEGIADIVKRITGTYPLNDKSGRVPTVAGVLTFTLAGAFAGLVAAPIACPFELAKNVVQTSVLVSNRAQAAPGAACDPSLRRKPRIGTVEAIQQIIKRHGFRGLYTGFHLHALRDTVGTAMYFGIYETVKQVAAKEIGSDQSPLGAPAIAGAICSTIPWFCTYPLDTRKTRAQSVLLGKSKEIGEASVAVAKSSMYKGISIILVRTGVNNMILLSLFEYIKARIDKLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHM8</accession>
    <name>A0A1Q5UHM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHM8"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000049">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012072738" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="9">
        <location>
            <begin position="28"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="10">
        <location>
            <begin position="393"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="11">
        <location>
            <begin position="528"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="619" mass="67911" checksum="79485AFDF36A9A37" modified="2017-04-12" version="1">MILKLLFLAYGLFSTAKVTAPFTWNNETFLLHGKPFQIIGGQMDPQRIPNELWADRLSKARAMGLNTIFSYVYWDQLEPSKGTWESSGNNDIARYFKTAQEQGLNVVLRPGPYICGEHEWGGFPAWLSEVPGMVVRANNKPFLDATQSYIDNLAKDLEALSINKGGPILMVQVENEYGSYGSDHQYVGALRDMFKNAFGLPLYTNDGGAKSMLEGGQIHGALAETDGDPKTGFSARNQYVTDPTSLGPQLDGEYYVTWLDQWASNKSFATDSGDAPSIQQVQSDLDWILKQNGSFSIYMFHGGTNWGFQNGADWGDALEPITTSYDYGAPLDESGRSNDIYHAIRQTIGSHVGADSIPPVPVDKPVVEIPPIKLSPYMSLFDSLPKPVSKHYPVNMEAVGQSTGFILYRHVVDSAMNGTLQPGDSPRDRVLVYVNGHRVGVIDNTYPAPSTVKLNLKKHDVLDLLIENLGRVNYGPRIIDQRKGIVGNVTVGGNVLANWDIYPLPLNTPPTPTSSNAKTSRPSAGSDPIFYTGTFDVDTVGDTFLELPGWIKGAVWVNGVNLGRYWIIGPQQTLYLPGVYLRETGNKIDVLALEPTGNEGSVSGITSRKWGNHPDPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI10</accession>
    <name>A0A1Q5UI10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI10"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="60" mass="6681" checksum="A738EF00EDD61648" modified="2017-04-12" version="1">MYAVMHGTYTGQILKCQGMPRDQLNGIDLTPENTGEVRLNSLNLTKRTKDANATVEYPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIS3</accession>
    <name>A0A1Q5UIS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIS3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIS3"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="109" mass="12128" checksum="0EF842AC88D1226C" modified="2017-04-12" version="1">MSFHASATSIELEDGHILKATLRNEEGDEVESELDLNDIIGNNNGSFEWGGENFQDSADEIEFTREERDEDEPIPVLRASLGNLDGENVPADINLAERITNENGHLKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ24</accession>
    <name>A0A1Q5UJ24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ24"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ24"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="87886" checksum="1B6C1E1F972E9E96" modified="2017-04-12" version="1">MEKLNTEDGQLFIKNLASFVRTHEKALANALQLRRQSKNVVTPQAPTSSSSAGASFSSTSLTLAAALSFGALKFTSQNIKPAKLTLTPHHLFYLLSRFEDLSIAVGPMNVRLENIHTEVSQSYVSFLNKPQRSKGDGASIHSVSSVRSVMSGMSGLWSSFGLGSKDSISKSDKAKVALEADLKYLYSAFTKIPCLRLAPDHRARLIRGYEEFPFDTAVPLHSFKNLGALEIIDIDYRSFYGWDRLSEQLRTLTVKRAHLDDPADLLTRIVLDDIDKRRRRSAKSQQSPPLGWTSSTTGTQPVHTPDHSISAPGSPVAETALASSTSPKSVPMMRAGSEGTKTRTRAESISPTRPSTKHSHRHSRGQSARIRRTGSGSSNSSDTSGGYRTGGSATLLPGVLPPSKWRFLRHLGLPENSLTSISAASLAPVANTLNSLDLSSNLLTEIPDSLASLMALRALNLSHCMIESLHSLTRNPLPAITALNLRGNRLRSLAGIERLLSLERLDLRDNNIMDPTEMARLTSLPEIREIWVSGNPFVKTHSNYRVIIMNLFRRTPGYSEDIIIDGRGPGYTERKQLVDRVAEPEGAPVVRSSAADQSVVVHKPISAVVVQETPPPVPPKDDVDFHPKSVPQLETESGTNRRKKIQRRRIVDLSTDNPFTTDGLGTPGPSMPAVLPVQQLHSPTNTPVVLPYEHQLRLDSGTPSGSSSIQSPIKHVQSSSPHAVVQPTPSKDWALDEELCRQQLEALRQEVGHSWISVLGDHPWDNAQKGFAAHHLAGAGLDHPVIPTAPLVRANSHAILSGGHALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ27</accession>
    <name>A0A1Q5UJ27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate permease A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="118" mass="12743" checksum="9D2E62A51F0814BF" modified="2017-04-12" version="1">MTYDNNPNTKVGNNMSSSDSNTDDIEVGRYGPLAHINTAESRLPAFGGEFQPGLYRPVKDRKIANPAPLGLCGFALTTFMLGCIQMNVKGLNKPNFIVGPALAYGGLVQLLSGMWYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJG1</accession>
    <name>A0A1Q5UJG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJG1"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="272" mass="29773" checksum="72C04CEBBCF1A3B8" modified="2017-04-12" version="1">MSNSQEEDGEDYYLPLQDQRVFGAGIRRKRVPFVRSSEHELSTINPERPSSIPPAPGPSIADTYLSIVLKKQNNSTSPSTPTGREVLTPVRTTNSAPPTSEAISPPPPAPTSKSQTPDHCEICNLPISSEPGSDTNTDTSTSRPHEASLAHQVCLQHSHPPSHLDRTRAGLRYLSNYGWDPDSRLGLGATGREGIREPLKGRIKRDTAGLGTGLDADGDRLRVAPPPPKKKVEKLNAKQARKGAFEARKRGEKLRRMFFQSDEVLKYLGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJY5</accession>
    <name>A0A1Q5UJY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJY5"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="226" mass="25627" checksum="18EA5D8856940912" modified="2017-04-12" version="1">MAATEKSQPTLRTARLELVPLGPEHREHTMKLDMDPTVMKHVAFGRPFTEDEAIQVHTWLMSCATMVPGFGTWAGFADGEFVGWWILGPVPKKDSPEEYLTDRTEYGFRVSPKFWGQGYAKEGGREMIRHAFADLGLAEVIGETMTVNTASRAVMASCGLKHVETFFNTYPTPPPGIEEGEVRYSISREEWYATQEVSVSRDLKQQSWSPGTALYNFYGYLRKMLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKC9</accession>
    <name>A0A1Q5UKC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKC9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKC9"/>
    <dbReference type="OrthoDB" id="5150166at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF2">
        <property type="entry name" value="DUF2264 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="14"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="413"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="717" mass="80297" checksum="CD99A6BE6A87B343" modified="2017-04-12" version="1">MPPLPGFSDNPFRSRDDLATAALALLRPLTSHFSPSCARVRLPVSTGTHFDAGAAELEGFVRPLWAVVCLLNLQSNSSDPRLNEVIEEVTSPWIKGFTAGTDPDDAEYWGAIGETDHQRMVEAEVLAYALLTAPQRLFHTRDEKTRRNITSWLRGMNGQPMPNNNWRWFRVFVNLALVKVCGVPAAEVLDEMNADLELLDSFYLLDGWSGDGPWLTTQEEEEEAAEFERTRRRDGIGKGRQVDYYSGSFAIQFSQLLYVRFASDFDQIRAEKYRQQARDFGASFWRYFDCDGSAIPFGRSLTYRFSCGAFFAALAVSPVPDMPEPLSTPGKVKGFLLRHLRWWASRSDDIFHSDGTLNIGWLYPNMYMCEDYNSPQSPYWCLKTFIAVSLAQDNEFWSAEEEPYPSFFKPQLVPAPRQILSNHPAGNHHFCLSPAQFVAWPMKATQAKYSKFEYSSTFGFSVPTGPLIQQIAPDCTLALSRDGAETWAVKWKCSEPTFTEVAVRTRMGISRVQATSVRWYPWGDRGVEVHTTLIPPTDRWPDWHVRIHRVRVNSALRSLHTVEGGFASPGRCSSDGTKMCDIGELSPDIEIGSSEGVLQTPDSVLMLSVVGATGLSSGMGNESASYSTKTQALKPDANTNLVHQRTLIPVIARDVERDIQAGEVFLHVTRVFAISGTANCNRRVGGSVEERWVDRPVVLLLGSDERDPKEDCIILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKM7</accession>
    <name>A0A1Q5UKM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKM7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKM7"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF15">
        <property type="entry name" value="DEHYDRATASE (PRPD), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="287"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="53809" checksum="AE1F72318BA66F2C" modified="2017-04-12" version="1">MEPAYDQPIADIAQYIFHYEIDEADENVWARARMALLDTLGCAIETAATSDECRRLLGLTRKGMIVPDGFRVPGTDLQVDPLEGAFDFGVLIRYLDHNDALGGAEWGHPSDNIAAILAVMDWLSRMSASARLTHTGPPLTMRTLLIAVIKAYEIQGCYQMLNAFNAYGIDHVVLVKLASAAVVSWLLGLTEEQTMACISHVWMDGQPTRVYRERDNTIPRKGWAAGDAVRRAVQLAFYVQAGQPGSPGALSSKPWGFWARTFGEAGFQFAQPFGTWTIQNVLFKAMPVEGHAVSAVEAILLQMRRFKAKGLSNPAQDIKQMDLRTTAAAELIINKRGPLRNAADRDHCIQYAVALACLKGSAPDAADYLDTSPWATNHELKCLMERITVSSDAELTRDYLDLDKKSIGTGVTVHLKDQSVLPEILVEYPMGHARNPESNAFVEDKFLQNMARTFSKTKIAQIAGAVHHPDLPVSNFVDLLACPASQPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL39</accession>
    <name>A0A1Q5UL39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_1282</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL39"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL39"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270870" description="chitinase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP13182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="672" mass="75241" checksum="062078016D97C50A" modified="2017-04-12" version="1">MNFLFRALFAFVCLVSTGVFAYSETDCNPLNQTCPADAALGTEHTWWFNSTLDDTLWNMTTGDIDYTSTGADFSIKTENASTLLVSNFYIFFGVMEVHAKMAKGAGIISSVILQSDDLDEIDWEWVGYNTSAVQSDFFGKGNTTTSDRGGIHPVANADTEYHNYTSYWDKDRLEWWIDGTKVRTVNYSEPLTVYGKNYPQTPCRVKMSIWPVGIKGQSIGNIEWGGGYVNWTDVPFTMSVQRLRVKDFHSGKEYKYDGKTGTYESIEVVSGNSTAKQEIEKTPSKTLAEKWDDLSEGVHIGVYCGAAAVGVIAFAVFGWWCHRQRKKGRLQSALDDGQNGAELKSLEAYKLQWRQSEWGQKSYQQAQAREAEKWAPGFAKSLQSAARHLGNTCTFDGTHVLAGTSREWIKACTGEDFDLDRFPIEFPRWQYSASTISLNKESLDLPELSVLRDEIERYQSSRFALFFPILDSSLIEDTINAAYHQKVSTASPAIASAKACIFALHALAIIVLDGSEQLPFHASLQYAREAHRHFPDIFSEAATLDGLQAILLLILCSQGLAADFHSINHLLAAASRLIYDMKGNYSPRMAWDNPSTIDYHTRHLFWIAFVCDKGFSLVTGLPPMLEDSQCDLTFAMIPPELLDQSNEKPHIYGDPYPGSLIGQLPYDRCEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULY7</accession>
    <name>A0A1Q5ULY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5ULY7"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1030:FF:000008">
        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024468">
        <property type="entry name" value="Sec16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12935">
        <property type="entry name" value="Sec16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 N-terminal" evidence="14">
        <location>
            <begin position="260"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="12">
        <location>
            <begin position="1155"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="452"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1510"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1792"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1626"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1663"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1682"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1721"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1813"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1831"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1880"/>
            <end position="1893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1932" mass="204369" checksum="EE6628C076688E87" modified="2017-04-12" version="1">MAEQTLSLDPANSWNPASWPEGDTPSNAATSTEGGLADLLAAASPKQTHASDIESPLNDEDFSAWNVSNEIEDKPPQVEDVDVVTSVVDDSPVQDAPGVGDIAEVTSTRNQGFDDAEAPTQSIEMPGSSDDLPADAEPVQTLLPSSEPTATPTEHVLSPTDAQDSQSTAHPESSVLAELEKEGDVTVLSVPAEQPTEFQEPVVEPADVIQQLPTPPVESEPVLPQSEEPLSTPFLPLPAGDVPQLEAESPANEPSTRDADPWSIEAHNDVDSDGDDFFNQLKTQTKPIFAPPEAESRFEEGVPLLDEDSPKSPEREGQPTEPVDDFFANDENDADDFFSSAQRVEISDEMSAPHITRKSTSQVMESVGFNIDSPTSDTSAAAQFDDILKAATTTGPVEPVGQAEPAAEPTEDDLAALWEAELSDTGEDELAARWEAALDLDDDDMLLEDTTAIAPAQPQAGTPGQQYVPHSATPSATNAGSAGLSSPFETPNSQTQPRAVSGIYTPHQPTTADLVGGIPIPGAPPTVNAVIPPYFSQQPSNPVLPPRAESFVEQSKEGYKSPYDLPDDLSRPRRPVVTHKPAPAPVTSMPPPPPPNSGIPQYGAPSPGTAPPTAAPALAAPTAPKNFYEELPLPVPKSRPATSSGRYSPNPAVITATGSSLAAAPPPHNPYAPAAPLAALPGNVSSQPSLQPPERLDPYAVPSVLASSAPAGPPVASRYSPQPPGLQPSAKPPSIPRYSPAPPPSGPAPRNRYASQPLAVPGHVNNLPFQPRTSSPLAYHEKASYQPEDTQVKQAQPPSLQPSVDLSPPRAQRPSIDQGSPYAPRLSNGVGNLDGASPPVAQRQTPPPPKNRYAPPEYVSEFAQRVAPNSANTPVPAAAVVPPPSQHANDSQSAPPRRSHTSSPGQQMTSPRAAVPPLTTLPRPASVHGSSSPTKTTNPYAPMHPSIQGRARALSQHLEFIAPTDGQEQDPLQRWKGAPIFKFGFGGSVVSCFPLQIPRYSVGQATPMIKPSPGEPKLSQASQWVPSADTIVQHPGLLKTKSKKKDVLAWLSSKIAAFENDMPHGFDQSHPDIQNRHEEKILLWKVVKILVENDGKLEGSAEVQNSLRQVFVPNLPELGPDGSVISPLGTSSGFSSQGALSQPDATADSQWMEEVRNLLLLGEREKAVWAAVDRRLWGHAMILASTMDRAIWKQAVQEFVRREIKSTAANTESLAALYEIFAGNAEESVDELVPPSARAGHQLISMNDRAGSTKNALDGLNSWRDTVGLVLSNRSSEDQLSLLALGRLLASYGRVEAAHICFIFSRSAVFGGADDPQANIVLLGADHQRLPCSLMDEDATLLTEIYEYATSVLASSPVANLPYLLAFKFLHAKQLADRGRKSEAQIYCDGVAASLKANTRPSPYHHQHLFVEVDELSARLRHTTTDGGSWISKPSMEKVSGSMWARFNSFVAGDDSDAASTGSGKAGEIGDFGPFANVAGTPTVSRSPSVSDLYGSYPGAAAAQPIPAPAGGSSRYMPNQYAPNASPEQFRGRSSMDSQRSPSFGGVPFAQRRTSQEYPASPVESYAPMYGSPGAVSGYQPTPPQTSYMPLAPVEEDLTAQSPADVAPPTQATPAVNGLFYQPHGQQEQQQQEPEQASATQSPYYQGPPGMPQPEASSYMPLPSNAYAPPSYAAPDLNSAPEETDQPSAVDEEPQPRKKKSFMDDDDDDDLAARASAMQKAENDRKADEAFRKAAEEDAKRDAQQSPKKGWFGGWFGGAKKEAEKTGGGPIKAKLGEENSFYYDKDLKKWVNKKDPNSAAAVRATPPPPRGSAPPSRAASSGSMPPPVGPPMSGAGSRPQSSASDMPPPPLSSSPALSGLGVPPPLGAMPRSVSTGAAVPTPPGSSGGPPPRPASSLTHANSIDDLLGAPTARKGNTVKGKKKGRYVDVMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMD5</accession>
    <name>A0A1Q5UMD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_847</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMD5"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="633" mass="70396" checksum="DCA00296EF705E26" modified="2017-04-12" version="1">MPNRKIVRNLSRLSGKSLKETLESSHEVLEIDSDDWLTSPDLSEDGLPFSTENFYETAVFLMANPNITSSHLFRADILFDSQGLLKTPQQDEELAGTFGGCATEIPETPVKAKPAAQVTGFDLVRTVIRKLIPRNQNIDRPLVQTCHFYKSKTSSSRDDEDHSNDDQPSERQRVLTMFLPHIESQDDVPFYHPQLRGLATLYDVQSSQEGVKSGTMSVHFLPFSSDIPERLERTLHLLLNFYVRLTRGAKGTTTNEITGKTSSSKDNLVPRHLAQNTYARLKNIYAADLCENWAESTEPSKHVYEDLAITAFLIELWRMMYGVAPAKENPNGENTTAKFPGFVDMACGNGVLVYVLLMEGYSGCGFDARRRKSWSVYPDWVQERLTEKILIPKPFADITEAGDIGVNITTGDFPRDTFIISNHADELTVWTPLIAALACPESPLPFLAIPCCSHALSGSRYRYPLPKGTKPKTTTGAAEKPDQHTEQNPQPASGDLKALRAAKQAEKTESGMWTSMYGLLTKKTITVAEEAGYQVEKTLLRIPSTRNMGVIGGRQLVSEQWKQLGTSSAPTVAEDQTKQAPRVVQNVMDIVERECSREGGIQASAQIWIERARGLQKDRGKATNPADDAQILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNK1</accession>
    <name>A0A1Q5UNK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="381" mass="42425" checksum="D8DB56568BD874CF" modified="2017-04-12" version="1">MSSPHNLRPRQGGEKEYTELDSETEKEETDTTVEADTSSEDSEEKSCVSAGKSDKKVDSSDGRPSSSRPTARSRRLPLPLSSRTRASAISPTRLTDRTVDLDLTRLYLERTANQQSDSNQTTTMSDTNPNLNQAIQNKAETNPTSNQAINNTSGADQNPNQTINMSDTNPTPVRQAPKRITSEPALRDVNGRAKERPEKDRSSQSENGDWNDGPSRGFDKENRVYLTPRRQLNFAQRHFMRKALRKDPPIPEFPPPRRAEETAPVEETAAPEEEAEEPAPARDGLSHDNVLPEYGYGYGYDVADDDEPSCFRDTLAAIEARDALLAGLIGPSSYNDVLRAFERADSYLRAGARTQYPEMAGETGGDDSWMEEFINMDEFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNK6</accession>
    <name>A0A1Q5UNK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_337</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNK6"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="72"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="404"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="609" mass="64814" checksum="8CA6B15D0C60F096" modified="2017-04-12" version="1">MLPQTRARMPAALRSLSRSNATVRTLSTTLPRFQNADKALNKVSRTITQPKSQGASQAMLYAVGLTEEDMNKAQVGISSVWFNGNPCNMHLLDLNNKVRQGVQDQGLIGFQFNTVGVSDAISMGTTGMRYSLQSRDLIADSVETVMGGQWYDANISIPGCDKNMPGVLMAMGRVNRPSIMVYGGTIKPGCAVTQNNADIDIVSAFQAYGQFIAKEITEPQRFDVIRHACPGEGACGGMYTANTMATAIETMGMTLPGSSSNPANSQAKYLECLAAGGAIKKLLAEDIRPRDILTRQAFENAMVVVNITGGSTNAVLHLIAIADSVGVKLTIDDFQAVSDRIPFLADLKPSGKYVMADLFAIGGTPALLKLLLKEGLIDGSGMTVTGETLAKNLEKVADFPEDQKIIRPFSNPIKSTGHIQILRGSLAPGGSVGKITGKEGTTFTGKARVFDTEDDFIAALERNEIKKEEKTVVVIRYCGPKGGPGMPEMLKPSSALMGYGLGSSCALITDGRFSGGSHGFLIGHIVPEAAVGGPIGLVNDGDVITIDADNRVLDLDVPETELSERRKDWEARKAAGKLPETGLTMRGTLGKYARNVKDASQGCITDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNT6</accession>
    <name>A0A1Q5UNT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetracycline resistance protein from transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNT6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNT6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="24906" checksum="245BD2A00A04F56E" modified="2017-04-12" version="1">MPQYLGDGSIEVGVYITQPHDWAENLSLNTQNIEAIKKVILDEFEGWAPELLQFIRHSQNAEFRPLYMLPVGWTWENRPGVTLIGDAAHVMTPFAGQGVNLGMQDAMMLSRAIIKGANSPAPKDALSNEIKSFEKDLFIRAKETATLTNDLRTMFFFSGLLRSVIEQVVLHHCLLSPGFIEIISGKNVTRLPHLLSQVPFLLPHAFRDHILDDVIDEIQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNW4</accession>
    <name>A0A1Q5UNW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNW4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNW4"/>
    <dbReference type="OrthoDB" id="3553547at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="479" mass="54820" checksum="14132C0E3419AEB3" modified="2017-04-12" version="1">MLIPAIHIQASLKGATWSDTRSEGDTPTTPFWEEGELVQWNSQWINDGQALSSTSSGTLQPPYPRFPVAEPPCTTSTTPVIEAGEMEDVGPSGESEDKPKTINAVHQGEDSVPVSTLPQSFDHVPTQAGNTSTRLAKLLDELRHLQQEVRGKRSRARDLRRALRNKREEEDYLRLVLREKLSWVSPEALYQQTTAINKAIDDLKAATELYRILENDYSRMEDELDQRERFLDKRLGKLNGLLRKQAASGTKQTDTVSSDSNFSSEPSSARASDADRLPFNAAAYLTLVGEVRLLRERLYELESEYKNLVDQESIRQRIGLSLAPEALTFLAHYETTRTKTQTGLDFAIRRLIAHPEHKHHPEAVVLDEEWEQVVQNFRPSSPDNQAQRDPLQMTEFEDRSPFFEERRPVPLNKFTFVNRWLLHQLRHSSFQVLQYKSNPEFVHLVDEGWDGDDISQMALMLWYRDETTGIVPLRNDIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ35</accession>
    <name>A0A1Q5UQ35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ35"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="811" mass="91494" checksum="B9384C3EA6E3D190" modified="2017-04-12" version="1">MPRSPDSNALALKRKLQQADSHSEPTSKRHHLQGYDPKAPWLHETKPINGWRTLGNPAVYNSLPLANMVSAVQDLIDPDFDPLTAILEDEPRFLKPLPDRIAPEDLEFLRFRGALSIPETGLRNELLRSYIQWVHSFMPVLNLQEFLRCVAENDPEGNVSVLLFQAVMFVGTAFIDIKHLQDAGYSTRKSARSAFYTRLRLLYSLDCEEDRIVILQTLLLMTYWSDPENSLHQDIWDWIGVCNTQAHSIGLNKDPSASDMDPKIRRLRMRIWWCIYSRDRLIAMGMRRPLQVNEGTSNIPMLKMEDFDFEPYSPSVVALFHCRQLEDVSHQKRLATMFIEKVKLCQCIGRVLFAQYAPSQRQFGATDRTTVTLIPRQASESEFTRCSQKLDSWLSALPKDAQFIPASRNNFRDGEDVLLLHGAMLRMLYHATTSALHRPWATYSKDQSKSRLEWRNIARTKMQDAATGITHIIQGLNQLNLTRFLPQSGVTVILPAAVAHLSNSTSDNPAVRESSISNFHRCVQVLHCLKDIYPAAGVEFANLEAAIKMQTGNHNSNTFFQIMQYNFDTTAPSFADARKPSSADSIATTHSLRHLEDKSIRDAESPTSRARAASININANANSNSNGRTHSQQHNLNTTSPPQNTTSQNQNTCRPFPNDFDDHFAISNTPISPSTENPFTYLSFDFDSFPDLSPAPTTTNTHANTTKDINLSPTTDLDSIDWTQALFRNPDLDKHTDIFSSDSPRRTQSLAQQVREPEQDQDLFAFTLKDDDEIGGGGGDSGAQFRHHSTGHRHGDITGDLDRDLGLDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQN6</accession>
    <name>A0A1Q5UQN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Carboxymethylcellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cellulase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_5845</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF6">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="17">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="286" mass="31415" checksum="FE91AEDCF6208E6E" modified="2017-04-12" version="1">MGSLKGTDYIFPDTGTIQTLIGDGMNIFRVQFLMERLTPNGMTGSFDSDYLKNLTTVVNYITQAGAHAVLDPHNYGRFNGAIISSTSDFETFWTNVAGQFKSNDLVIFDTNNEYHDMDQTLVLNLNQAAIDGIRAAGATSQYIFVEGNSYTGAWTWTTVNDNLKALTDPQDKIVYEMHQYLDSDGSGTSETCVSTTIGKERVTDATQWLIDNGKVGVLGEFAGGVNDQCKTAITGMLDYLAENSNVWKGAMWWAAGPWWGTYIYSMEPPSGAGYTGMLSTLKPYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQP6</accession>
    <name>A0A1Q5UQP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_5860</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQP6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQP6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000006">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="99"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="15">
        <location>
            <begin position="226"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP14796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="677" mass="76328" checksum="F5D7DEC87C773DBE" modified="2017-04-12" version="1">MASSTGTAPKSYPLSAAEISRTVAIISSSSKLGLKFNSITLLEPRKADYAAFRDSSGPRPIRRSLSIIISRVSQNVSEVTVNLISQKVESWRDIKDVWPILTLEDLDVIERIARVHPQVIEACKGLGITDMSKVFFDGWAIGVDERWGLERRLQQALAYYRTSPTDNQYAHPLDFTVIADTEREQILSVDIRTVNGERTHIPMEEHNYLPELVGKSQYQFNRLKPIHITQPEGVSFTMHGREIHWANLKMHIGFNYREGLVLSDICMRDPFDSNNRYRTIFNRVSVVEMFVPYGSPKSPHHKKHAFDIGEYGSGFMTNSLKLGCDCKGAIQYLDAVVNTSNGDPLLIENAICIHEEDNGLLYKHTDFRDGRVISARDRKLIISQILTAANYEYAFYHTFTLDGTYMLEVKLTGMLNTYCLHPSEESAPFGTEVANRIDAQNHQHIFSLRIDPEIDGSRNSVIQSDAVPADIPADQNPYGNAFMAKKTLFKTAKDGAANYCHETSRTWDIVNPNIVSKISKKPVGYKIVNTQCPALLAQTESIFAKRGAFAQKALWVLPYRDYELFPAGSYVCQSTGEHHPNNLTITDWVARDESIENTDIVCYVQFGLTHFPRTEDFPIMPAEPVRVMLRASNFFEKNPALWVPPSELDADFSSTRVPLETLKEHGVQGKSAVLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR31</accession>
    <name>A0A1Q5UR31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="5351" checksum="30A1D80477F383A6" modified="2017-04-12" version="1">MGKVPPSPGSLSSIVCAQPVCATGRPAVTQVTSAGLWLAGINGNSVLTRELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR91</accession>
    <name>A0A1Q5UR91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Telomere length regulation protein elg1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="568"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1162" mass="128056" checksum="CC3ACDBDB07F476D" modified="2017-04-12" version="1">MGQGEQPVVHPFFRKASAATSKLPPDVSSPAMTTSTPNRTSQMPLHYSLGLPQTRLSNTSSPDEDPNAGRRKRRKTERSKQSEHDQPLQAGLSGWLGVEAPASIAPKSSEINVESSTSSMPPPSTSVEPQPGITTIEKEPVSKDTTPLQDAPTRPQKIVKLNTNGRLLSSPPLSPPGTSTLKRASRKRGQTRKAESKMVVIKYALAKKADFGKTIDDILSGRVKHNAPSLSPAVPLRRPVQPKINDNKPTHPFFVKKATSKQPPVGSCDPQCTPKSLDIKANSECEQSRTIEKPLRALSSGFARQKNKFPELVHPVWPPRDFVHVTDLGPSQLAQASMGNLENDHKKSKSPTVVVPDNENTLLTSTAWARKAASLELQSLDNYKPALRLPGRHVASGRVLQAALDSQMSWSLPGQRSSCASSLPVIKRLHSSLLTSVSAFDCGKYESRLWAHKYSPTKAEDVLQVGREARMLRDWLRHLKVSAVDSGKQPKDGAKSKAKRDRRRKKRKVDVELDGFIVTSGEEASEMDALSGSDDELAGDVTVSAPKTLIRSGDLAFPGQHGGEKGRLTNAILISGPPGCGKTASVYAVAKELDFEVFELNPGSRRSARDMLEKVGDMTQNHLVHLLNEKDDSASKLDQVADVHAKQNKLMSFFKGQPSKYKNSKPANGAKANSSPTPETECKHSREQKQSLILLEEADLLFEEDRQFWTGVLTLISQSKRPIIITCNDESVVPVQDMSLHAILRYQRPPLNLALDYLLLVAAHEGHALKRDAVDKLYNASGMDMRRSLMDLNFWCQMAVGSEKGGLDWILPMWPPGANVDQNGERVRVLSLNTYQSYMGWFNRDTFGVDDSLVREAQALENTFQWWQLSIQDAEDAAGASTMEQLPPQQHRSMTKLEQLDLLSRETDYLEMRSSLDILCSRCPMGMFEDVLDTSAPPISESHRTNYTDAHLLLQADLLPEHPSLSESISTTFGSLISRVFRPKAEDIESAGASRIFNGWAQSAARQSVSPSTAKGFRKVFEPIIRANYSTPLAVGRAAPSFENGLAPITEDIAPYVRAILVFDGRLKEYRDNLFAAWSQGQGGTGDKRMRKTRASRAALEGGNKASTRKERWFPDDTNYYGIQGTGRPEWQQILFDMGYFHVQPVAESAEGSSESPSGDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URP0</accession>
    <name>A0A1Q5URP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8860" checksum="848B201B14EAF906" modified="2017-04-12" version="1">MAGINSYLGDDIQGGKCVHSALEDARATRKVVLWCLRHPDKFKSWVAMMQGDHSMLVRDREEPKRLAEKWMTMQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNR4</accession>
    <name>A0A1Q5SNR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thiamine pathway transporter THI73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNR4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO89515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="497" mass="54276" checksum="BB80CA2930251D31" modified="2017-04-12" version="1">MSETKESVSNTNPVACITAADDALNFLNQQGDTGSSPRGLADIRHKVDRRILPFMFCCYFLQFIDKVMYNYAGVMGMKADLKLKGNDFSNAASAFFIAYLVTEVPNVYFLQKIPPAKWLGFNVICWGIAATAAAGAKDYTTLLVARIFLGIFEATVGPSLMLISSQYYTKSEQAPRFTFWFLGLGVAQIIGGVISFGFQHVHSKFASWRIMFLVMGLITVLVGFSTLFCLPDTPMQAKWLSDDEKVALLQHTRINQTGIRNSKFNFRQILEAVLDVQVWLFCLMVALQAVSSGVVIAYSSTLIAGFGFGGPVSALLNAPSGIVSISFTLLVGIGIRKASNRWAWVFVCSIPGIIGGGLMSFLPKDNRAGVLAGIYLVNAIVAPLPVIYHWVAANCAGYTKRAFASAAVAGFFCVGNIIGPQTFQDRDAPEYRPAKISVLATQAAAAVLAVVLFAYYIKENRRRERLQNSNGGEDPISDEAAWGGLTDKENQSFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQQ7</accession>
    <name>A0A1Q5SQQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQQ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="324" mass="35194" checksum="2F53610D382D3C07" modified="2017-04-12" version="1">MTGIMQGIFIDPTVQQPPTRDLPRAVVLPDTLPTPKETKHHPTDGGNENASVFFVGNATVIIEWAGIRIMTDPNFLHAGDHAQFGAGVSSERRTNPAVELDDLPRIDLVLLSHYHGDHFDQKVEASLRRDIPIITSPHARTQLTNKGSESFTNVSALAPFETSLVEICGTGGAKRPLLRITGMPGKHVPSNAVVGLLNKMANAIPPTTGFILELGTSTDTHDPTDFTPGYRIYITGDTLMTEDLHSIRLKYPPEEAPIDLMLAHLGGTMIPSPTLSPLAFMVSMDAAQGVRLMKLIEPEVTIPIHVDDYEVFGSGIGEFWGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQV7</accession>
    <name>A0A1Q5SQV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacilysin biosynthesis oxidoreductase BacC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQV7"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="376" mass="40939" checksum="1F6596346195CA83" modified="2017-04-12" version="1">MSQYLPQISSQSLEDKVVLITGGANGIGTSLVQQCLESGANVCFGDLDNISGERLLRKSLEGFKPAEPKHPQRIVFQSTDVTNYQSVLALFDLAFNTYKRIDHVVSAAGIAEIGNWFDFGLTLQTVRQTPTQKVLDVNLVGSMYVARIASVYLRHNRGPGVDRSILLFSSVSGFKESPSLFIYQASKHGVIGLMRSLRNYISSPYKHYLRINTICPWVTQTETMKQIEQQWKQASLPTNTTREVSTVATGMLTDASLNGTSMFVEGGRAWEIEGNIERLEAQWLGEAPSKSLAAGQELLDDGAIWTAKPRKRSSISNGIPPGVPLEKLKGIQQNGARKNSMNGLTNGHTNGVTLVTNGIANGLTNGMTNGIVNGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ST30</accession>
    <name>A0A1Q5ST30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ST30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ST30"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="321" mass="37298" checksum="56A8E0AF9F6259D8" modified="2017-04-12" version="1" fragment="single">HIHSASFRSDISTEIDPSTPTTSSKKMEGLLSELFNGNWSHYLFRRPGLRRAPGLEGALFKGWTFDPNQIRDDNWGMVVKSLIYQSLNKVGLIPFEALVELSRGQVTPTLRDFLEEYELLYSQICSFYVKRPYSMKSGGHLSLMKEHLEDKTIGADPFIRTVVQDACDYVVNKHTRKRDLVEDLRHFITNPLRDQLHEYVPHNILLRRKKVLAVRLKAYISDASNMWDKPFDSSTTFLDEYLSLEPRALAERITKVDHHLYRKLKVSSFLEKGQDLQTLQQREINLTRSVMECLDTQILNVEQVFELAKVISTLRSRYGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVL8</accession>
    <name>A0A1Q5SVL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVL8"/>
    <dbReference type="OrthoDB" id="3535998at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40220" checksum="1963501DEC6BD31C" modified="2017-04-12" version="1">MVTFNALLVRENWFTESPAVVHYQGAGRRIPKSRRIMSSSKEGGPPKRRESRSGTRKVASLSAEQLERKRANDREAQRSIRQRTKEHIEQLEQQVAMLQAQVNEMRPRNEQFDDLVRQNTALQEEIARLKHQLANYTSRQGFAGSGEQAGLFRSGWHLGEGPSTATPNIPTTNTVLSSNFPAPTHPLANVPRAPSELSASRRSSHPHEWQQSYSSTRSSSLGESSDPEYSARMDPYAMEGQLHQVSRMVGPSLPLATPQMSFGSAASPAQSGSASSFSQMYPVGQHPPSGQRGDGMQPVPQSSMNQPAAGYMPSHRSISIPMPSASAPAQSTPGQPYQPSSALYQNHPGQPPQRDPSYQYPWNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVP2</accession>
    <name>A0A1Q5SVP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVP2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="8537" checksum="772C31F196A186E8" modified="2017-04-12" version="1">MRVWSGMREIRRKPAAYEPKNDASVQFSASRALTAALLRCRADRRRTDFLLNRYAQCAHFRQCFRTTEYSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ88</accession>
    <name>A0A1Q5SZ88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-rhamnose mutarotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ88"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="13342" checksum="33C4352AFB014FCF" modified="2017-04-12" version="1">MPQVRRVAQIVHLKPSAVAAYKECHANVWPEVLQQIKDCNIVDYSIFFDNDHTLFATFKYIGTDYDGDMEKMRANPKVREWWAMTDGMQESPIPGAIGSAEGPGWWKVLDEVFYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T068</accession>
    <name>A0A1Q5T068_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolases family 2 sugar binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T068"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T068"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384550" description="Glycosyl hydrolases family 2 sugar binding domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="3">
        <location>
            <begin position="125"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="205" mass="22804" checksum="01054452766E7372" modified="2017-04-12" version="1">MQLLRSIVFSLLAATSVAVPRGDASRHQTIQPRAAKYALKEPPLTTPWTDKVGTDPWPEYPRPQMQRSQWQNLNGIWQYRGASSLAEAQNPPFGQSLEQEVLIPSCLESGLSGKILSLQQLVLRGPITHQTIGIQGNTTLYSWFSNSFKVPSDWRGQQILLNFGAVDYEATVFVNGKQAGFNRGGYSHFTVDVTQFAKPGQQNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T069</accession>
    <name>A0A1Q5T069_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T069"/>
    <dbReference type="OrthoDB" id="5339271at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="32173" checksum="F85F1817D47B7A6A" modified="2017-04-12" version="1">MAAYHSPYYAEVYDLGLARTPWACDDAAIYLDAYKQMSSLRPRDPSHDYLVLDVGTGTGRVFRQIAEYMIQENISPAYNRFIGVDISPHMISRAKEIVPKSLASRITYTVGSALDLQAIEGLQGPPKVDLLIFAYASISLLSEPGAAEKFLRQVVKVLRPGTGRAYIPIGYLFDDGRQSEADKINQRYADASTRTDMPSKKYPNVFYRFPEGYMATRREGNIVKYAVPMQVVEKGTGGQERVIEAESPTTSVRMWGDGEFLLEAQMAGLQLVEAKRTFNETSYVFCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T246</accession>
    <name>A0A1Q5T246_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11596</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T246"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T246"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000316">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841057" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="17"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO94329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="530" mass="57938" checksum="1FC3A887BD6F0BB6" modified="2017-04-12" version="1">MANFYLFFLLGLAAAKSPVVDLGYTSYEGRSLASGVSQWLGMRYAAPPVNELRFAAPQDPLSQEGVQQATQHGAFCIPVANSLNTAVPHGSSEDCLFLDIYAPTEAVQANKKLPVYFFIQGGGFASLSNQNYNGTGLVEASDLNIVVVTFNYRVGPYGFLAGEEVENGASLNNGLKDQIKALEWFGGDPDHVVIGGDSAGGASVTLLLSAYGGRNDKLFIGAAAESQSFANMLNVSESQFAYDKLATRTGCNTNSDSLACLRKLDISALQAQNIRTPYPGAPGDPLYLYGPTVDEDLVQDHTLKLFHEGKFIKVPVIFGDDTNEGTIFVPKGTASVTDADNFLKDQFPTITQAQLSKINSMYLTEDQKQDFPNAKPYWRPASNAYGEIRYICPGIDMSSVYAAANLPSWNYHYAVLDPWSEGNGTGVSHTVEVNAIWGPQYVSGVPPDSYWNINANIVPVMQGYWTSFVRSLDPNTHRYPGSPEWKTWGTGDDAYKRIFIRTNETRMESVPQAQRDRCKYLIGIGESLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2U6</accession>
    <name>A0A1Q5T2U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2U6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="76" mass="8330" checksum="EA2C339914E87744" modified="2017-04-12" version="1">MSKYQERPSAHSALPYTAGNLTSAHGQAKFDTIDLARAKRPVDHGKTMLLPLNNHDDLQILKFVPGGEQLSTEMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T3Y6</accession>
    <name>A0A1Q5T3Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T3Y6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T3Y6"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF3">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="239" mass="26949" checksum="FF3675EBBAF002B1" modified="2017-04-12" version="1">MTSSSSDIATSSGPSQHPFFRGNIGPPLRTFTDAAAAPAAHVRILPAIKHDHRELEAHIHKILQSEDPDEQTRYQNKFIWELARHTIAEELIVYPALAKHVKNGKSIADKNLAEHQGVKEQLKKFQELSAGDPRFKPALQRLLEDLERHVEEEEGEDLILLEEGLSRADSEALTRSLERMKMFVPSRSHPGAPNKPPFETAVGFLTAPIDTVADLFRKWPPPGEEKKEEERKRSLPIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6J5</accession>
    <name>A0A1Q5T6J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NASP-related protein sim3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6J5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6J5"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="305"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="449" mass="49017" checksum="5D6D9B5024BC6A36" modified="2017-04-12" version="1">MADAEQPTAADHIAVPTDKRAQLNDLITRAAAKDASKDHNAASELYSQATELQAELNGELSPENADLLYAYGKSLYNVAVSKSDVLGSKVAGEPSNAPAPKATSARSASTDGSLVKDAISSSMNQNAATPSKDVNAQLDAAPSKPFFQFTGDENFVDSDDEDEEENGGDEDENDDDFEVAFEVLDLARILYLRKLEIAEESSTDKGKGKSVDLPADVKHIKERLADTYDLQAEISLEGERFSDAVNDLRTALDLRNSLFPFEDPSVAECHYKLSLALEFASVQQQGEEDDSQEKTVDEEMRKEAATQMERAIESCKVRMASEEKKLEADKDMEEDKVVAAKRKISNVKEIIADMEQRLIDLRRSPVSIEEKEKENEAMLKGILGEIVGQSVTDQKARLDAVSKEATDLSSLVRRKPAAAQTSSQQTSSKRPADDASADGESKRARVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T829</accession>
    <name>A0A1Q5T829_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10567</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T829"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T829"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="30704" checksum="C49DDC69613A109F" modified="2017-04-12" version="1">MASVTSPSSVNTQGSPTQAPAEKPSPPPIDILPSQLAQAYSYVHPAVLLGLYAYRFEALVADPVRELLADLPWLAALQISFVMLCLPPAGSTSTEAGAGAEEEKKKAPKSPSGPLRHGKPGYRRKHSSGKSSWACFFAKLMPAFLSFALTSLLATPLIAVLLVLFGAPLTTHNAETILCAAHMALLSATGLVYVHGVEASVWKEVWGIARPVDAVWGSALGTGLGAWFGAIPIPLDWDRPWQAFPITILTGAYIGYAVGSLVSRTPLLYGKRIEFAPEQAEEEEKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T891</accession>
    <name>A0A1Q5T891_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmental regulator flbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T891"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T891"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000315">
        <property type="entry name" value="Developmental regulator FlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="399"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="515"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="688" mass="76785" checksum="5EBF0CFC478D957A" modified="2017-04-12" version="1">MPVPSVIHYREESLPYPDPSVPDSTTPLSSSNRFRASTSTTTTTFPPTTDPPTSSTTTFTGSVVGSISRRNRRSFAALAQKTSSALASLSTISTISQPTTYNTPSTLRSSNSSGSLSKLTKSSASTPLTPPFDGDPYEQLPASRSVSPEPSLQRRRLTLQRVPTPPHDPRPVPTGAAPTAPPKMHQTSSRLLRMTEDERPFTKDFMDLFSTLMVSLKLDSHRVRFTRYDHTFTSEEAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKEMARSVCQRFVDARFIEAVDGKALPIFPLKGALFQLTPKGINILQRFCQRNGITARHVMDVLESPRNTMQLVNLERDTDTDKLSHDRATIEVIFRRFAGQDGPNIKSSISTSDSDSLSDYSNGIIGVKMARERKLQDNKIYTNTFTGKGAVDWLMDCSTTIERRETCLIAELFLKYGLITMIQDDKSYPDSNAVFQPSKYAIYCITERGQRVCGWIARDKPRDNSGTYDNRGMPRDSNNARLTHILQDPALRLLFREFLRYSLCEENLSFYLDVSEFTANYHKAEKTGTFNKVDSVRETLAAAYGLYNAFLAPGSPCELNIDHALRNSLASRMTKAVGDDESMYKSLQEVVHLFELAQTSVFKLMSSDSVPKFLRDPKYSVVLQEHDVDIFGGSRSYSPTPGVPERSMSRSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9F9</accession>
    <name>A0A1Q5T9F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan polymerase II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9F9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9F9"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="456" mass="52171" checksum="899DC3E1A0BE2031" modified="2017-04-12" version="1">MNRHYASPKGYSAYPRGPNDFSISPNRSFQPRSQPALRRRRQLFQRLLLLGGVSLLLVIFIFPSWRAAIIPTLSLGLVHPSEDLHLQTVRYYDLSEVQGTEKGWERGERVLMLTPLRDASSHLPMFFSHLRNLTYPHNLIDLAFLVSDSRDETLGMLTRMLQEVQNDPDPKMKFGEISVIEKDFGQKVQQDVESRHGFEAQASRRKLMAQARNWLLSATLRPTHSWVYWRDADVETAPFTIIEDLMRHNKDVTVPNVWRPLPDWLGGEQPYDLNSWQESETALALAETLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMELDGIGGVSILAKARVFRAGVHFPAFSFEKHAETEGFGKMAKRMKFSVIGLPHYTIWHLYEPSVDDLRHMEEMELERLAREEEEREREQQEQKEPKESSKAKAHSAAKGSDKGSDEGPAAQPAKNSANDASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAJ5</accession>
    <name>A0A1Q5TAJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC multidrug transporter MDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAJ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAJ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="780"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="72"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="304"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="638"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="958"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO97259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1199" mass="130182" checksum="1C1059116D3512BD" modified="2017-04-12" version="1">MADTAMSEQSERTPCSNEERQRIECQTRMETQDRFGYWSLYRYAGSVEIAGMVLCTISAIGAGVVTPLMTNIAFYDHTGAGELAARMTVNINAIQDGLSEKVGLTITGLATFVTALIIAFVRSWRLALILLSVVAAIILTMGGVGKVMKRFQAQALETSSAGSTIAQEAMSSMRIISALGAQSHFEKKFTSSMAASDQFEIKWRATLGVLIALMMFIMVTQYALAFWKGYQFLENGETTISRLLTTIMASMIAGVSFGHIAPHMGSFGAAAEASNKVFSLIDRESPIDPGSMEGQQLSHIEGTITFEDVTHWYPANLEGPAVLNRFSLNIPAGKTTAVIGASGSGKSTLVALLMRFYLPAKGSILVDGHDIEQLNVRWWRQQVALVSQEPVLFNATIFDNIAYGMKGAEPKKVRMKPQYPLDHGSRQQQVTEASIAANAHDFICRLPQGYDTMVGEGGALLSGGQKQRIAIARALVSNPRILLLDEATAALDSLSELSVQSALDTASHGRTTIVIAHRLSTIQKADNIVVMAAGQIVEQGSHEELLSQSGMYFSMVQAQGLQETRDQERAGSDRVSVSLSGVKDNLEVDGSRSSVHEIPSSINMNEAIHDTNNNQVGGPQGLLSFIWSMGMPELCITLGGFVSAAFAGCVYPVLGIMFGNVVFALTPTSRGSSSLSVNFWAGMLFMLGILALVFYLVQGVAFAITAARLIRRSRSRAFAAVLRQDISFFDRNEETSGALVSFVTTDIQAIAGISGATQGAVVNFVFTLIASIVIACSFGWKLAIVCISTMPLLLFCGFLRTWILTRLERRTRQSTAASALACEAINAIRTVAALAREEALSQSYDETLVRQGPKSLRDLLQSSFLYALSQSLSLFAMGLAFWYGGTLIAHGEYTVKQFFICFVSVIWGSQAAAGIFSFANEIGSARQATERLQDLLSRTPSIDSWSPVGLQDDIHGDIQLRDVYFRYPGRPELSILRGVTLKAKRGQFVAVVGASGSGKSSIFALLERFYDPNSGSVEVDGRPGSQYHLQHYRRQIGLVSQETVLFSGTIWDNIVAGLDNVLRDEVIQACKDAKIYDFIISLSEDFSTFVGTKGFLLSGGQRQRLAIARALLRRPKILLLDEATSALDSETELAVQVAINRAAHGRTTIAIAHRLSTIQHADWIYVMDAGRVVEQGTHTDLMRIGGRYWHLAQATVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAL9</accession>
    <name>A0A1Q5TAL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAL9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="71"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="582" mass="64690" checksum="DBDF8E4FB0F42E01" modified="2017-04-12" version="1">MRSAKAVISEKFARLGSPTATMTYSTAPSQRGPSHTLTSLKRWSVATRELPAVSQIKTIHVYDFDNTLFLSPLPNPQLWNGSTIGFLQAYESFANGGWWHDPNILSATGKGIEIEEPRAWNGWWNEQILRLVKLSMDQKDALTVLLTGRGEANFASIIKRMAASQKLDFDLIGLKPEVGPNGQQFATTMKFKQNFLEDLLYTYEQADEIRVYEDRVKHVKGFRDFFGSLNRGLQAGNGPVPRKPFSAEVIQVTEGCTYLDPVTETAEVQRMINAHNLTRRNPSLAKVKSQYSRLRIKRTVFYTGYLISQQDSQRIIDDLLSPMLQQHGYAEANDLKYMANSILITPRPATPSILGKVGGMGKKVSWQVTGLGVFDNKVFAAQVAPIPSTEPVHTENPSPLIVLACRRGSRPADAGRIHNWQPVPAGMALKIDTVIGEKVVLRVEDENPYEGEWESQFVNKNNKRRHQQERDEDILYPHSGHGSGGYEAMNQGQSQGYHPYQRPSGDNRYPNDENSRRGSHRGRGRGNGRGRGPSRGGRGRGRGGRDAGSNPYYKSLDDQGIGGYDGPHDKGGNGAGGFPMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAQ6</accession>
    <name>A0A1Q5TAQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAQ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7144" checksum="522CA02AFD72B8CF" modified="2017-04-12" version="1">MEALGHSVDSNVLWRTTTLRKNEIEVYYHATGNICIWAGSLFNVRYTKKAEDAMVGRLTGLGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAU2</accession>
    <name>A0A1Q5TAU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAU2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAU2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012186054" evidence="1">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="178"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="408" mass="44251" checksum="8C5C0DA07D277774" modified="2017-04-12" version="1">MTAVSVLVAVLALLGPSLSSRVEGSSLPAQAQVINQRSFNVLNTTQPPAVFNAESLFVPPGYTAESLVKRPFHVYDEEFLKIIGKSPTLTRIAHSPKDPLFHEAVVWSKETDEVFFVQNAGAKDADTGLHKSAIIEKISLADAASVSNKSDAAGLVKVTTVPSSPMVINPNGATNYRGQFIFTGEGQGNNTPPALWLMNPQSPYNTTVLLNNYFGRQFNSLNDVVIHPKNKDVYFTDTIYGYVQDFRPAPGLQDQVYRLNPDSGAVTVVADGFVHPNGLTFSPDGEYAYVTDTGINYGFYGMNYTQAASIYRFDVKKDGTLDNRKVFAFVNAGAPDGVHCDSWGNVYAGCGDGVHVWNPSGKLIGKIYLGTTSANFNFAGKGRMVICAETELYYVTLAADGNYIESEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB50</accession>
    <name>A0A1Q5TB50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB50"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="876"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="769"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="867"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="935" mass="102834" checksum="8F94CA37DF04B261" modified="2017-04-12" version="1">MSTPSTPRSARSTRSMSPADNSPSILTPGQKIKAMMAQFDSDSDSDSQATNSKTYIPKLDFGSKNTSTGILALEQPNDFDSDSDDADEIVRPKGRMAARMQGDANPSTNSTGPQQDSAFSRLSNALRTEREQTQKSTRQRASPVDESSDDDLPAAAPRRRTNAQSTQSPASADEDPAKSPSRARSVSPLFVPNDETAADNISDIETHDKPKSNARFLALVAQKRKEREERERIEDEQKAARRSQLEHFSSEIVSGEESEGEEAQSARQLSQKARQPRKASKKALEEMRQETQRLSRNMQLAHQAQTKKKITKESLFARFNFMQPEASPAEPTAANSSSTAASQHSSDGEKDKQTPHTSPVLGPSDADKSTAINVTEVPAGIDEHNVNEISTSSLEKATGLVPSTLGAPKEFTVLSAKKMPRKPTQPPVRVLLSRQEVARHQQEDSDSDGLEVVTSPSKARRIAAFENLPTRKLQESSSMTTLKALAHLTSPSRKHSGMNSAELSASLLYKARQQAAKERRERIEELRAKGIVIETAEERATMEDDIENMMEKARQEADEIARKEKAANKKGQGLDDDDDEDEDFYAPSGSDDDGSNRDDEEEDEDNDIDENPGFLDNEADEEDESADDQAEDEMSDVDMLAEAPSTRRKRRARVVNDDDEDDEPQVPSTPVRPPSHDPQSVQRPVFPGIETPGGMSMGLTQAFAGTLADDEDATSQPASSTMSFSLPDPGRPVPRLRAEDSEILVRDSQEHPHEPEFMTNCTQNVTRVSESPAAHKFSQYSQLPDPTQDQGFIYSPFDPNKRFRETPPVSTVDTVLLGQSQSPIAERKSRQLRRGRAANLSMVEEDENEGDFEINANAFNVMKKAAKKESVPYDKKNSKAKNIVDEAAEESEDEYAGLGGASDDSDGEEDAYDQQMINDQSGEVVDEKQLAAMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBJ2</accession>
    <name>A0A1Q5TBJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000693">
        <property type="protein sequence ID" value="OKO97583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="446" mass="50459" checksum="53F74F9BC1C83F40" modified="2017-04-12" version="1">MAGRAAMRTPEPPDRDEREDSPPRLARSKRTTRPPNNYAREQEINIERRKTRSQQKKTPIEQEERISATSGDSSAEDESLSIAGIVKELVKLRKEIKQRDESHKEELRQVKEEFSAALAEVRHELQTLTDSYATPQPHLEACSRDNHDEILREIQSLREEISVPAPTSFPSYAAIARAPPLSHPNNIRPLPTVNTRPTTLTDTLYCTIDTSKMIEENNKKISAGLIRTIIETDVRAMGDHTHWRCRAVTVDPRNTNRIRIACRDEDEHQLVKQVAETKIGAGARVLRDELYPIKVDSVKRAAVLDENHNVLAGAAVALGEENETTVAKIAWLSSKETTKPYRSMVVYLTKSTDARRLLADGYFHVGGESGTTSIFEYRPRPMQCYNCQEIGHKAFQCKNAQRYAKCAAEGHRHSSCDQTVPKCVPYGGPHESFSRNCRKLYPPRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBV2</accession>
    <name>A0A1Q5TBV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBV2"/>
    <dbReference type="OrthoDB" id="4365020at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="21225" checksum="FF22EC83668098E6" modified="2017-04-12" version="1">MVIVWTPEWDNKLLVAIWETCGSKFDWETTAEIMGGSCTPEALMQHLRTITRKAAERRREQREILLQAHAARAASVAKGKAKRKWGYNRSALKRIEELGQRYDSDVSAGSKSKTTLVLRPKQTTPSDSADAPAVKDDRNGMVRQKGKKRKNPAGDETAEASALQVEIEARSKSRHRGTFWNNYQRGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCG4</accession>
    <name>A0A1Q5TCG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCG4"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="161"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="342"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="451"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="803"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="914" mass="103177" checksum="E0A353D985B1EE57" modified="2017-04-12" version="1">MAEDQMRTIRGISLQDPTFDNRQDGLGIGNTKPQISWRFVHNDLNIRGWQQQGYEIELERRDTVETYRVDSAESVRVPWPSLPLCSREIASVRVRSIGVSENFEEPTTTEWSAWASVETGLLNKEEWRAQLITGQQETSLENPIRPLLLKRSFEIPQVSQSISKARLYVTAQGVYHFYLNGTRVGDHFMAPGFTSYRFRFSYHVFDVTNLLQSGSTNFLAAEVGEGWFASSLWREGRQIFGKDIGLIAQLEISFNDDDEPLVVTTDAEWEWNTGPMLASEIYDGETYDMLEERPGWKTGSDPQVGTSWTEVTVLPLPSATFSAPDGPPVRATEEVRPQRILKSPSGKLLLDFGQNLVGKLCIRGLQKPAGHRVVFQHAEVLEHNEICMRPLRAAKCTDIIVCSGGELESWSPSFTFHGFRFVQVEGWAPQDERCPLRVENITAIVLHSDMKRTGWFSCSDDMINRLHENSVWSMRGNFLSIPTDCPQRDERLGWTGDIQVFSPSANFLYDTDGMLADWLVDLELEQNEDNGVPPMIVPNVQYAKESRPPQAVWGDASILVPWALYKSFGDKDILSRQYRSMKSWLDKGCSRGEDGLWTTSLWQHGDWLDPSAPSEDPGNGQTDGVYVADAYLVYVTGIISQVATVLQCREDAQRYSEDHIRLKHVLQEKYITPKGMVMCDTQTSLSLALFFSLFASEDQRKNAGERLARKVRFAKFRVATGFAGTPIVTHALSRTGWHQLAYRMLLETSCPSWLYPVTMGATTTWERWNSMLSDSTINPGQMTSFNHYALGSVINWLHEYVGGISLVEPGWKVFKVQPIPGGTIRSADIQYESQYGLIKCSWQLDVNSVFSMKLQIPPNSSALVIMPEKEANANSGTILSSGSYDFSCHYHADPWPPTPLETLFKPPARKVICQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDL6</accession>
    <name>A0A1Q5TDL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">4-hydroxyphenylpyruvic acid oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PENSUB_9406</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16189"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="EC" id="1.13.11.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16190"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDL6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDL6"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000022">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="24">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00029786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OKO98308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16701" checksum="6DC939A3F8641E1F" modified="2017-04-12" version="1">MPINEPAKGKKQSQIEEYVDFYNGAGVQHIALLTDDIIRDITNLKARGVEFIKVPDTYYIDMQARLKQSGLVLKEDFETIRSLDILIDFDEGGYLLQLFTKHMMDRPTVFIEIIQRHNFSGFGAGNFKSLFEAIEREQELRGNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDN2</accession>
    <name>A0A1Q5TDN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein sft1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10921" checksum="E149B4A05320FF87" modified="2017-04-12" version="1">MRGIKILSIIRYVSTAEDMSQSWRLRRSFQIVDLGLNTADIDFFAQNEVFSSFSTNLKGSASRLTRMAKQGDTVAVLKVAGIFIGAGLLIYIILGWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE89</accession>
    <name>A0A1Q5TE89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE89"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="32143" checksum="F6B51D9E85C94847" modified="2017-04-12" version="1">MSRAQRDQVQHIHLFTQQYFLEDSNKLWSRIWEGTILEYTPHGDYFRPGWGRRRVEAPVPVDNRDKEKYVIAPKKLTITFRHTDWWFWENDEPLGIDPFRLGRTRAHEMCHHHHHQLNTQLTPEQKRAWGNQFTHIPSLTTLTIEFETIMRKRDQLDAIIDQALNWKFPLQPEKSVYLVAQPESRSAWTWVGAKEGDLMRQSISEGRRVMDDDIENDDDSTAEKGVGMVPQVPVLRAFDAKERDAGAGQAEVESDTEEFYVIFLTWKKQVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF88</accession>
    <name>A0A1Q5TF88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF88"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30125" checksum="68DFF69E95467C96" modified="2017-04-12" version="1">MSSPPSHWFPQGIDPGTIITLDQPVPSRWKILEKLNERDFQASEEMRRRHDCYSYATARLLCCDPKKPSRKAFMRVYLQVPIKYTEIQDPKTRSRQATTYTPPELTAYQEFTRQDFRNAPKLLGYMVSTQDKPGPVPNGFAIWLAWEMVPGLRLGDKLGNDPYWTLSAAERERVRMAFMTDLPRAVAKGFGPHVVSLSRLVWHSQTGTLYFIDYFYGINDAPKDPSKIKIGLEALARYGLAKPSSNEWLNKDWNGDTTGWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFB8</accession>
    <name>A0A1Q5TFB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RWD domain-containing protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFB8"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="168"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="32390" checksum="D8879A3CC66DB0D3" modified="2017-04-12" version="1">MASKDASILPADIIESQLATIDLIAAMYPSPGELEIPESTTECIERLRDWCQEPTSTPPKIPTSISLTVCLPIADEYKTIQVNISVPLQSEGQQSIDQPPPLGYSLRQPDWMSKAEVAELAASMPKDDALEAFEYIQTESARFLETKQSQATALEGPNTKSGPLVRVWFYFPSLSTRKKRDDMVNLAPGYSLTGFVLAGKPGVLCLEGLSVDIDAYMSFIKTHSWGDIPSHQKKVSERFRETEGVQRVFPGMEEITDSLGERGGQRANRGDMQALEAWLGNKGLQEAFEKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFW5</accession>
    <name>A0A1Q5TFW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFW5"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000261">
        <property type="entry name" value="NADPH-dependent 1-acyldihydroxyacetone phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="33222" checksum="A3E1D7A2D09A7C27" modified="2017-04-12" version="1">MPGVTDTRKSVLITGCSPGGIGNSLAREFNRNGLRVFATARQAATIADLAEIGIETLSLVVDDQESVKACFADVQKRLGDKGLDYLVNNAGRNYTVPAMEVELDEARLTFETNLFSVITMCQTFVPLLIKAKGTIVQIGSVAGIIPYVFGSVYNASKAALHSFSDTLRVELAPYDVKVITVVTGGVQSRIARTERTLKPDSMYLPIEEEYNRRVVHSQHNAMPNEKYARSVVTQVLYGSAPWRWLWPWAQGRKTTIWEGRMSWLIWLLSGGWAWNGLFTRIMTRMFKLWKIKAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG38</accession>
    <name>A0A1Q5TG38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="96" mass="10423" checksum="2C9E174A3829804C" modified="2017-04-12" version="1">MSMPNSPQGSSTAGRPSWQEQLQGGRTAWSSNLTIQGEIISARYWYDGQYINNAKEDAAEVAVKKLNEQPRSSTVYPGQLYSQQSSAGYGRGAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH96</accession>
    <name>A0A1Q5TH96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein efr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH96"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1170" mass="127447" checksum="3F76414D082ACFEC" modified="2017-04-12" version="1">MESVRQSCRPRHQVLTLKCFPKYQKGVAEVIPNPSELSYLLYYASTRRSKLTKVGAFLEKRVAKDVWRRRLGNVQVALHILTALIEKVPRELPIYARYVLSVIDTVLRSNDISMVEDSIATFETFCRHQDIAIIAADQALANKYREVIRTYASFADPSSQSYSSAKLSPPVAIRWRNAGLRAIKGVVSSESLAADGGTSLNIILPVILENLYSSNEDVLVPLKAKIRETDDGERDAARLRRLSVATVHTVDTADGDPALAAQSTADADRQAEMDARLLALRCLEQIIVSGSNRGQIRIAATVILRFIANKRFPRTATLDEFSGMSQQDGNWATSLIELIATWCPVQVRFVILMTAMDILHDTHPKEDALESSFTILSVVDWLLKSPVNMIGLSVMDILLGLMRYISDLLSPTDGDADKNADSNAHSAVFISPRRRALLSLLEQCIGNLATHNYYGDQVADMMRAILRRFKPTPNHESAAQSSLATVHETRAVSMAPQNSEIEQTNGEKAQGETFSHAAAKLTALKAVKAILVVANLRAPASIKGSESRNQVGIHVWEGTQGLLRDSDQDVRHAYADAFLSWLQLETNKQDLKVQSDTPKYVKPASKRDSEALDKTSGRRSTSAPGNQREKAAVAAQTKFLRLLHLDIYDAAMDRPAVGSEVLVLHLLLASLVENLGVNAAQFGLPMVLKLQDDLFTSVDLGSFAAQVNIGSLVHGYLLALAEKFNLEATHAGVEVRNEIEKRQSKGQWFAKIKLPPTGLDGIAMDEKVLDEDSTQSITLTPFRNLDGLVSGIDEAYRQIISSPPQSPPTSSARGFNFPVLNHIPAKQPSQEENGLPSPVKELMLSSWSRESCLAAIEKESIRTASISGSRGGTMTRNSHFNGMTNGSPVGSAMDKNRPMSVPDISYTPEPSSGRGSPVRVTELRRVLSVNTESNLRRRSPLRGQVDASNISVISSGSESMASGVYSVSEMEQDALSTMQDEAQQTHEDGGAETPRANASAVALSTDQGQDSTLSREPSYEIPPVPPIPAGLSIPGGFPNDSQRSLISIDRPATAPDNSRQALKSSVKSDSSQNLRNGKALNRNKSRSSNNLAYGFSDGFYNAENDSDTPLDTAQRDQLRKLLDGFLSPEDNVVTNGDRPSTAVPTSKNSLADGYSSRRQVSGGGLGRPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THE3</accession>
    <name>A0A1Q5THE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THE3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="482" mass="51751" checksum="D0B8B107E0D74274" modified="2017-04-12" version="1">MAHELGGTAIEAFWAGTSFTLCSAVFQPVFSSLSDLFGRKPLVLVTIAWFTIGAIVAGVANNFTHMLIGRSLQGIGGGGIITLTGILIADIVPLSERPKYFGMLSGIWSLGTVTGPVIGGCFAEKVTWRWIFYINFPFIGIGAILLAFSGGFLTAQGAFTVQVRKIDFVGIALFLPSSASFLIPLTWGGVLYSWDSWHSLAPLIIGAVGLCVFAIYEWRIARLPMIPPAIFQNRTALISFGGYAVVGLLVWCCLYFLPLYYEAVKEFKPIMSGIALFPETFTVAPTGVIIGLLISRTGRYYWAVCSGWCISTIGTGLLCLLDTNTTTVAWIFLNAVAGVGIGMVLPSVALAVQASAPTELVAIAVATSTCFRGFGQSIGVAIGGVIFQNRMKSNLLQYPALRGLADKYSGDAASAVELIRGMQDTQAKGDLQQAYADSLRMVWAFCCGISGLMFFTSLFTKPYSLDRGLVARVRPEKENVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THZ6</accession>
    <name>A0A1Q5THZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THZ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THZ6"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="35524" checksum="F2DD7B4A43A87F22" modified="2017-04-12" version="1">MAPKRVLITYGVDVDAVAGWLGSYGGEDSTNDISRGYWAGTVGTRRLLKLFDKYDIKTTWFIPGHSLETFPEDMAAVRDAGHEIGLHGYSHENPTDMTIEQQRDVLDKTYRMLTEFAGKPPRGSVAPWWETSQEGAQLLLDYGIEYDHSMSHEDCQAYYLRTGDSWTKIDYSQKAETWMKPLEHGTQTGLVEIPSNWYIDDLPPMMFIKKAPNSHGFVNPRDVEDIWRDHFDYFYREYDEFIFPITIHPDVSGRPHVLLMHERLIEHFKKHEGVEFVTMEQVCDEFKKKNPVPPGALMPAPVGEMLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI64</accession>
    <name>A0A1Q5TI64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI64"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="13">
        <location>
            <begin position="229"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="436"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="501"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="514" mass="56292" checksum="43FF0F05ECDA35C0" modified="2017-04-12" version="1">MADSIYTNYPPTLSLAQQEYLVTTTKDWAIQNGLAVRPAQTALPEGADANRVLATNAPVTLFPSPFPKTCFEEARALQTVYNQLYAAITCNEEWLGKVIAELIDVDDFVANLWKTHLAVKKEGYVQNLSLGLYRSDYMAHVTPNHAPALKQVEFNTISSSFGGLSALVRSLHTELLTSPPGTPISYPPHPLFQSGVPPENTSVETLAGGLATAHKAYGPSKSTPELPLCVIFIVQDGERNVFDQHALSKRLTGFHKIPVFRVPSSKIFDQTSVSTSDPSRPLIYHPPHSPSTAFEVTTVYLRAYYSPDEYTSSRDWDARVHLERSAAIKCPTVLNQLAGCKKVQQVLAEPTGPDHLSSFLKGTDPTVIARLRETFAPQYDLSANGQGRNLALNPETAMKHVLKPQREGGGNNIYKAEIPDFLKSIPESDWKGWVLMELINPAANAENIALRNDGEVLRGNVISELGVYGTILWDNTGKVLHNDEGGWLLRTKGKEVNEGGVAAGFSSLDSVLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIT7</accession>
    <name>A0A1Q5TIT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000650">
        <property type="protein sequence ID" value="OKP00138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIT7"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="536" mass="58616" checksum="CF294A959FCCB012" modified="2017-04-12" version="1">MSPAAIPEELQPQPDLHQDQLQAVGKAFDALLLTLYRLTHRHNDLKKYTDEAFKQYTNVTRLLPPQDRPHAMEVQQRLLDQQKQLCEGLVHSKPPVEEQSLNSMEIMKTLVSHQNVDENSMRAIVDGVKGYKALLRSDGLSQISSENSCLFARGPDPSVSLEQDFTTNGTQGSLHCPFSKPKSPRPGSDMASSKRSDGGPKIQIDTCGHDHLDPIHADQEERRSSTTPSVGRSSQGRCPVSRCPIRYLDKHSPEEIAEYVERHKHEIPRSHAICVKRYQRDPQNMRQLDAKYGGLINMISGLSAKHQAFLPERETNGDGDGQVEGEGEGRSAHSASPERVEKWAEEVDPVTPVPPTHEVEDRESRFDRPLREVRVGESPSRPWGIPVPITEQPPASSIPFPGSASGPISPDAVPVDPLNQSPGDAPAKPAGRCPFGHDAPKAKPAASPSVPAPAPAPAPAVHLESPWSNWGNFDNVGKGETAEHDAAKVEDGPPKTDTKPQVPTHVTFNGPVFFGYSAEETASLMQQLAHLNQGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJ12</accession>
    <name>A0A1Q5TJ12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000648">
        <property type="protein sequence ID" value="OKP00209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJ12"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJ12"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="51643" checksum="F94FD61ABCB93242" modified="2017-04-12" version="1">MAPLFGSCDPFYPSSEPCTIGNLVQFAVNVSKLEHVTETLKFAKQHNIRFIVRNTGHDYLGKSTGAGALAIWMHNLKDIEFEDWEDTHYKGKAAKLGAGVQGMEAYQAAHKEGLRVVGGECPSVGLAGGYSQGGGHSALSSKYGLGADQVLEWEVIDGTGRFLVANREQNTDLYWALAGGGGGTYGIVWSMTSKVYPDGIVSGLNLTFSATNISMDTFFKAVELYNTHLPSIVDEGVMSLNFLTNTSFTIGPMTAPDMPLEKLETLFQPIRDGLDKLGIKYKYQSEEFDSSLAQFQAQMPLVEVAIAQYGGWLIPRSLIHENNHGLTESIRSVVGNGGVFTTVAINVSKKVSGDVFNAVLPAWCEAIAHVVLSTAWEWNDSKHTHAAQEKMTNDFVPSLMKLAPNSGAYLNEADFRQPDFKAAFYGTNYKALREVKAKYDPHDIFYGLTAVGSDEWTVSSSGRMCQVVSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKH9</accession>
    <name>A0A1Q5TKH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKH9"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="44802" checksum="43C83B0E699E2EDC" modified="2017-04-12" version="1">MAAPTMSTMIDPTKQAEYPIVLGERLANNTGSDRLINVNYNYKSKAATPQQRSTITRSSRSRDLYDLSVTDKPPSADHTLTYSYQGSEDPTGERTLVLVFDPDRKVFVLEPVSTKLNFNIRSAPGKTEKQVLEQYEQLRISQEEDHTSFDDRNGGNTSEDEGPADESNPYDFRHFLPKEGAEDVKPASRNSTPEPVYTSKANTPVLPPARPAAKPAPRPKTQRPQANPLRETKRVQKPPIKPKVPREIPAEPVSRAEPPVDQEDSRLSVSDAGTGNGSQRSVPSPGSNIILDGDLIIDMGSPPPRRAFQVNPSFFSSNNTPNDDRDGDESEAEIESFRLPSPARDTKPASSVPADTGDDMEDDDALAAEMEAAFEASAREEEARSHQYGQSNYRVASDDESEVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKQ3</accession>
    <name>A0A1Q5TKQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor tau subunit sfc6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKQ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKQ3"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="728" mass="81261" checksum="AA57B1B507F17D46" modified="2017-04-12" version="1">MASARRSGRLKGPRAVYTDDLFESAGIADESDSEERQPSGTEKRRRRRDEDSASDDEFVAGEVNDEEEEEEEDEDAGEERYVDVMDDNEPAATPRTPRTPGGRSRPKTVQSQQKLLESSGAANRSTKASTTETRTRGCIDPRENVSKPMYYMSTFGDDERDLLAVVYTRDRWGRGVDTCLPTRHTLDIQSTANDYEYGPTCGVAPDDMVKERTSGWDWYYDKVIGKEFRKPQKIGPKLKEADARRKYLPKPKKGKHTILIGAANDQKTFHLGHHESMNLAHAWGETKAQKSDQASAIVREGWIISFEQKIQCLAWAPNQDGFDQYLAVVTLVTPEQKEKHPSHGIEPPSPFRTAPSYPCAIQLWQFTGKQAGPVTRTLDMETKPLLRLVLCTDWGDLRRIAWCPMAREKRAEDDQNGMKSIGLLAGIWGDGKMKVLDVKLGPDKKTEFVTIQSPIFEAKSPSNVCSCLTWLSPTDIAVGCSDGFVAIWSILPTSDPEPIPYFYKSIHASYVLSITSAYPTNPHLIATTSIDGETRLWSMIDPESENTTPVRQRQAPGHLSYSPILQSVCSYDENEFGRLMPIHKFFATQSAGRMPSSVMCLAPCSFFHPSLLFGTAAGEVVATNPFRRLLYSKEQHWQQTWFSHDWAPGLIKDSSGASRFYEGYRAETQSLARNLSGDKRPQLGSSLTTVHDERAHVTALGWNPNRASAGWACAGTGCGLLRVEDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL02</accession>
    <name>A0A1Q5TL02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL02"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL02"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="31963" checksum="F8582FBA3E8ED1A4" modified="2017-04-12" version="1">MSDPTMNSPDGAGGKRKREGSDDLGHDAQRLNRSSHGSNGSMPDNQHNFGHSIGYDHGLGNAGSELNIDQQILQHVGPQNGLSDDNALTANAKAALAAHAPQHKYPPPPDAAAFDANNLTQGLNFGDDMGQGPIPGPHNHNSTAAAVYAAREAQSMNQKPTVGSPEWHQIRKNNHKEVERRRREAINEGINQIARLVPNCDKNKGAILQRAIEYICQLQEEKKNIDERFEQHSLTANHAINEISASNQKLKQEVSRRNAIAAKWLQRCRDAGLEFDDYEEAKELDTLDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMC6</accession>
    <name>A0A1Q5TMC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMC6"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="34224" checksum="8E7F59E8A93DB5F2" modified="2017-04-12" version="1">MPETRYVTLDDLLISNFADSFARHYSYECKATTQERPYTARPSRTQQLLNPRLVPKLSEDVPTDVQTTGIADEILAKREAERGRKRDHDKDDEDRYGQSPKRARSLSTDSADSISTISTNRSASASPKRHSRHSSRANGRRSSASPPPGETRKRRYSDASDGSSAKSYSSGDRQRSRSRSRSREWTEDRNIRRRRRESSPEERGRNRDSKKHEPRKTDRRSQSADKSRIAKARRSMTPDATYDHSEKRSYRDREPLQGPSQSGRSRQDPRVRGGPPRERSMSPYSKRLALTQSMNLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMF2</accession>
    <name>A0A1Q5TMF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMF2"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP01372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="124" mass="14719" checksum="8D3504FCAB3F62A3" modified="2017-04-12" version="1">MNFVSGFFSGFALTTSVLYITITVHRATRLEQRRQIREQVDQINWLAASAGAYDRRFFPEHKPRSLEERKSQKEDQITLKDVLKHRWNQEVGNFARNAHGNRWESVKETACHGWNDIMRWVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ20</accession>
    <name>A0A1Q5TQ20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7088</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ20"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP02324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="418" mass="44846" checksum="FAB20EF5EB744BC5" modified="2017-04-12" version="1">MLLSTSSNRLFRRAQLLHCCRHTYSSIGSRYHSRLSIPLAGQLTPAKSTGSSSTLHLHTANPLAIIPRHTGQGYSTATTTPIATDSMEPNPVTHYTPPQTGLIASLPKSWIPYAELVRLDKPTGTYYLFFPTLFSTLLAAPMATGVAPLQVLGTVGLFFTGALIMRGAGCAINDLWDRNLDPHVERTKFRPIARGALSPKNAILFTGSQLLAGLGVLLQFPSQCLWYGIPSLPIVVIYPLAKRVTNYPQAVLGLAFSWGAIMGFPALGVDLLANHDAMMAAAALYTSCISWAVLYDMIYAHMDIKDDVAAGIKSIALRHEHNTKAVLTGLAVAQVSLLGAAGLAAGCGPVFFAGSCGSAILTLGLMIWKVQLKSVSSCWWWFKNGCLLTGGGISLGLLGEYAAQYYGLYDKEELAKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU88</accession>
    <name>A0A1Q5TU88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU88"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="32639" checksum="0F37ACC3BA72924E" modified="2017-04-12" version="1">MAEMKEWRPVKANDRKHPNNHPPIIAHIIHFFYQSPLPWRTLAYAVGMLENTEYNHSRRRRSGIVRTNLSVDAKRRVYLTRRSRRGCGASGIVRGDWETGSDLESGDEESGVESIDLTDISRSFQSSRNLEVLCDDRNEGERMELDQSVDVDLPEREDTQTDSGEVSLSDFANLLEESQSIPLETSSSDADTEDISPCESVELTQEPDSTHVEQALNDTIELDKPHRDFLPGKKNLVEEELLEYIPMNLKIPAHARPKSNRRSLESIEPILDRKAKLPLGPADAPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D3</accession>
    <name>A0A1Q5U0D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0D3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0D3"/>
    <dbReference type="OrthoDB" id="4355419at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP05940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="207" mass="23299" checksum="B2E2050D2815676B" modified="2017-04-12" version="1">MNRRKVTVDGISACGKTRLIAALSEYATAHYHGKVKPQEYFSGEPSPITSIEIQSPESGLIDFWENSYSTYGRLTPLAYPKTTLVLFCFALEYVDDTRWEVENRVDYLISKKSPKGKDASLILVGCRNDLRKKQEDARSTKTLTKASEQLRQYAKKNRLAGYFECSAETDENIAELLRTVVGILFLGDTGDSTRKHRKIGSSKCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0E6</accession>
    <name>A0A1Q5U0E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chromatin-remodeling complex subunit ies6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0E6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0E6"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP05928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="20516" checksum="724AA0E083AF8863" modified="2017-04-12" version="1">MAPATPAKDDEAHQLLLSQLDIAAVPKPFRNPHWKPSQRRNKNVKAIISETTRKEASQLATQVNSGATTPFPATSATATTDGAASPAEGAGKAPNLAQAARDLSTLVLEKNARAMFPSGPAVTYTNIESAPSLDPSNKRHYCDITGLSGPYTDPKTRLRYHDKEIFGVIRNLSQGVPESYLETRGAHTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0P8</accession>
    <name>A0A1Q5U0P8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0P8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0P8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP06055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="761" mass="84903" checksum="7215009BB024DB3F" modified="2017-04-12" version="1">MSESKRIIWQTGTLTIHLVVGSDEIVRIVGILPHDSCQAEQNALYSKLGTVPLLGVRLNGEGNPSHKSSKTLIGSYVSSRLKYQSHHEHSDSQSKSLDIITYDEVSQISVIARLSVYLGIPVIRSTATIRNDSQEDIVVDQLSPLIVGALCEKSISCWLDYTLSTPTNSWFREAQWRDESLPSVGLDDIGLSELPGPHEASMAHHAISNRGTFSTGTYLPMGLLKKNDSSETWLWQIESSGSWRWELGDFQENVYLALGGPTNKDHGWKHRLAPGQSFASVPVALCHVLAHPDNAFAALTEYRRRIRRPHKDNEELGLIFNDYMNCLMGDPTEEKVMALVDPAVKLGAQFFVIDCGWYADDCGWWDDVGLWEPSTKRFPKGLRSLFDYIRAKGLTPGLWVEPEVVGVRSVVADMLPADAFFQENGRRIVEKGRYQLDYRHPEVIKRMNKVVENLILKYGVGYFKFDYNIEVVQGTDTNTFSPADGQLGHNRAYLEWVGKLYDRFPDLVIESCSSGGQRMDYALLAVHSLQSTSDQQDPVRYAAIAASAPTAVAPEQSASWAYPQPDWDDEKNVMTVVNSLLGRVHLSGRIDMLSSHQLDLIARGMLVYKLFRSDLTTGLPFWPLGLPKWHDNWLALGIAATSGVRYLAVWRRSSSTNLSLPIPALKSRDVEVKLLYPEMFEGNAQWDSDKGTLLPEYDSRIEHVVPVTPRLSNANKAGYGAGYGVSRAGKGGITVRGRSTGEVCCVARKGSYIRVFMIDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1T1</accession>
    <name>A0A1Q5U1T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1T1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="15044" checksum="2E2FF46F8A6389C6" modified="2017-04-12" version="1">MVYAQHKIRSSDPRPGRGWGDAINLLAYCSQLRDDLHGVNGEVEAGKGQITRYANGQRTRFTFKKPFARTPNVQITPILSNRSGAFQSFYLYLLNPTEGPPVNETRFYLGIFSSVGNTVQFSYFANDVDGEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1V0</accession>
    <name>A0A1Q5U1V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1V0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="161"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP06470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="31406" checksum="28926B616C2E05F1" modified="2017-04-12" version="1">MNTFESSATTPTGPRDSGEAQDIHDSSSRSPTHVDSALSSSFGSSRSHSSFSSRKYAGTPRSHRHQSNESTAVFDEAGASTRNYGATQAPNLSSAASGPTSNDKQSAPVPDNGNNGGNCSCSHQHNQHDEPHQSRYSRFVDRFGALELENKGSVARDHLALAWMRTSLAFASIGIAVTQLFRLNNTAATKNAFGLDVTSPGHPDILPSQFSSSSIHVTSASSRLRSVGKPLGSTFIGVSILILIIGFHRYFESQYWIVRGKFPASRGSIALTAFVAAALIIAALAVILAVSPGAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1V7</accession>
    <name>A0A1Q5U1V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1V7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1V7"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="691" mass="77533" checksum="B3FC09D774E88C4C" modified="2017-04-12" version="1">MAARRMIPWLYDLVLWLFTWALDLFFREIYPRGAWRIPERGPVLIVAAPHANQFVDSAILMHLLKSQAKRRVSFLIAQKSMNEPYIGTLASCMGALPVVRSMDLTKPGKGTIYQPDPESDPALIHGVDTDFTQPEFTPSGSLTIKGKDAPETASIDEILGPTSLRLKKPFNSRLSDDPGRKGTRFKVAPHVDQSQMFDAVYKELSSGGCIGIFPEGGSHDRSNLLPLKAGAALMSLGALARDPECGLSIIPCGMNYFHAHKFRSRGVIEFGRPIHVHPDQVAAFKAGGASKRNAVGSLLETIYEGLESVTQISPDHETLILVQSTRKLYNPISKKIPLPLVIEFNRRLLKGYTKHQDDPRVKGLKKMVKEYNRRLESLGIRDHQVEWGNIEEKPWWLTLITLFYRLCKLLVLSFGVLPGVLLFWPVFVTTKVISEKKRRKALAASVVKLQGHDVVGTWKILVAMGLAPTLYVYYTIIVTAWLRYNRNDGYYTNSVPWWMVARTYVPDFVPLWIFAVCFYAHMGFVSYAALRFGEVGMDIIKSLPPLLVALNPLSSSFLIDLRQHREALSERVTQTINDLGFGIMPDVDAEIPTDSYKHDAYQSYLKSMPPSEPSSRERSRSRSNGPGGAPSLKALSSINSEGDLAEIDRKIQTNLKGRGRRSNTLTTFETGESILKYKPLMTANEEKKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3E3</accession>
    <name>A0A1Q5U3E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3E3"/>
    <dbReference type="OrthoDB" id="4324345at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="372" mass="43113" checksum="847FE409931548C7" modified="2017-04-12" version="1">MQRLRKQHEPTWVWRYKHHTEVLQNIRTHLTLLLNESIPDSFVRMLNVKLHPLHFSTGKTFTDPAASFDYFFIPTDKRVSWNNKNEPIERTIEFPESLGKPHKPSSWPTDEDIQLQKDLEEELQKFCRLADSNQLSKRMTPIPRPKNMDKENVRTLAGSVNFHVSRAVEHRHGARVITLVPEAYPNPARPSSTEIQVLITVITQGLRQQSIEFGLSDPRARTKLHLDSVNYVIPTLIISVYPGAHVRVLYGYMVNNELHLHFTELQQFNNDNFPSMMEETLRWAFPIARGQAAKLITLPDLMEIDEEDDVEVEVWEDVEDCTVHLYTTHEEVDDHVQGTNQECMMNFSSTTSTFTTTTTRKIKGKKNSKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4R8</accession>
    <name>A0A1Q5U4R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4R8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4R8"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP07461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="40607" checksum="C2BA282631546A91" modified="2017-04-12" version="1">MAPSARGWQMIEIVTVLVALCFISVVLRVVARLQRRVGFGIDDYLSVVSMVLMIAMLVELGLWCSIGGNGAHVKDLNADTLMNYWKIFLANQFTYFLLCPAIKISIICFYRRVFTTPRFQNFTFALNCLISAWGTAIFLACAGQCRPLRAYWDHSVDGQCFDANLFFIVNQAFNILMDFVILALPIPMIWNLHRAWQDKLALNGVFALGTFVCFASIYRIVVLFWISPADPTYTVYQATLWTHVEPSVGLICSCLPIIRGLFPAFKLRNRSNRSDRPYYINTDMSNSNFLSKSSPRSPDLEYVKMEAGLYGAQIERTGMGRGRGMLGDDLHPLNIKVQTDIAITPESESNTAETVHGQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Z9</accession>
    <name>A0A1Q5U7Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000566">
        <property type="protein sequence ID" value="OKP08617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7Z9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="190" mass="21758" checksum="7A14586F400A50AC" modified="2017-04-12" version="1">MGRQKYTEKSTIRANTVYHEIPQKMILGRATYVVSNFQFTQRPIYLSPGLIMKATFGTRLLVNAADQDKPCFIRLGNEKEGSEDPVDLIENIFGPHWQRLMDNNVGPRRQFKILEEAIVHQFGCQGQNVFRTETVVDCHFGTEGSKSDSSTTIKILLELGWQEIDITLKDHYERNREKLIETCMDCIAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB65</accession>
    <name>A0A1Q5UB65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB65"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="6"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="33297" checksum="3FA9FE2882F3ACFC" modified="2017-04-12" version="1">MSCIPEWSPEGHIQLMDRLGIKKSILSITSPGTHLKVNDFELAKRITRETNDEIAQICRKYQDRFGWFASLPLPDVEGSLDEIDHALKLGASGFALMTNAQGYYMGDRRFDQVFKKLNDHKTIIFMHPTQCCSLDNPDADKPLAQYPTPMMEYFFDTTRAVVNLLLSGTVTRFENLTFLVSHCGATLPPIVERFTAFSTRMLQGCEKLTGDRVKELFRTRFFFDLAGMPFPDLIHGYLRVGQADRLLYGSDYPYTPGPVVEGLSHIMDTQLKEMFEEAQIQKIFSENAESLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB80</accession>
    <name>A0A1Q5UB80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB80"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="439" mass="47560" checksum="80B80689A042C682" modified="2017-04-12" version="1">MGGPSSNAAVTAIETTTTSSSFSLTSSTTPTSIATPTLTDSISTSTTTATTSEASVANTYTTSTSTDQSTSALRSSSSVLSSTLGIPSETAGPKNDASQKNTSGSRYSTGALAGSIVGSFLGGLIIAFLIAFLLRRYRKRASSALENGQGSLSGTPESPKDPTDSLSKNPNSSIIAGYKEPSHVSPNFMTLRSFDLTRYVPEPADDTTICMRIQTFFDQAGLHIDNYYSRQDFAPRLSQEDTVRVNDYGSPFLGTQLASLLSSSRNQRVVLTHVLIHNLLQSIRPGNSTRSLLPACYGIDREPRENSPSMSDDDHATFAWRMLTSYLNIRGQSSNPNDLAVRNEVIANIADDFNRTFAPYGDSRFSQMDRLSHLQSVVREASRLGIWLFSQPCSFEFHWSMASETNSIAVLPSVIKLHDEQGRRLVVPQSLLNETKAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBP7</accession>
    <name>A0A1Q5UBP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosylglucosyl-3-phosphoglycerate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000429">
        <property type="protein sequence ID" value="OKP09908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="158"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="470" mass="52025" checksum="81019474B253EF53" modified="2017-04-12" version="1">MVPILNAIGTAVAIRTIDDFGPDLICEAPSRTVKRLAKELREQGAELVVALTHQREHNDFELANNLPSNLVDIILGGHDHLYAHTLINGIHILRSGSDFKQFSYIEGFRDRDTISGWHFNILRRDIVSSIPEDPDTLQIAARLTSGLDLGFDKPILFTSNPLDGRFSTVRQRESSLGNFICDLLRFYYDTDCALLSGGTIRGDQIYPPGVVKLRDMLSCFPFPDPVTVLRIRGHALLAALENGVSQLPVLEGRFCQVSNVCYGVRLGGPPGSRITFLRVGGNPIESERTYTVATAGYMSRGKDGFSSLHIDRPDVEELVGEDSGAQIVKILRAYSLGLKVLGAWNCRYDKTEGGLPEPPFPNTSPESDKANNLGKTTGLQIHPKREGSNPDDDPLVPNSCIHAITSVSFGSPSFVDHQYCLFIARRAVRRWMRNIGFRTQTLRAIQYDADSPPDWMPTISPQLEGRILVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBY0</accession>
    <name>A0A1Q5UBY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28484" checksum="22FD295D3DABE595" modified="2017-04-12" version="1">MPVFLSTPKSDDAIVLPLKFTGGLGLPTKTIGFMLAVQGVYSMIAQLWLFPFVVKHFGTLRTFRFVLLAWPPLYLAVPYLILLPAKLQMPAVYVALISKITFHVIAFPAIAILLANAAPTSKVLGSINGAAASTASLSRAFGPTVTGLLHTRGLLSGYSVLAWWACGLVCVVGAIQSFWMEESPEPERFRDQDSEVSESELKHETMSTDSYAGRDSISEEEQRLLSLRSSLDQEFDVSTLSLDPIHDFSTPAETDLSSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCB5</accession>
    <name>A0A1Q5UCB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCB5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="17235" checksum="AA86A0F41633B012" modified="2017-04-12" version="1">MSSKKMDSAWRPVPNAPQSRQVAQSASTDFLWVDCHDGKSQDGGVARTTQAFLQTKYHKQRRKTQLQQLKASMKALPPARSPPVSTPGTESTLEKEDQDVDEERAHQLLIHQNDHRMHNSLQSKVEDLIPVTSQRLKQSADFYFDYCEFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCR9</accession>
    <name>A0A1Q5UCR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000366">
        <property type="protein sequence ID" value="OKP10286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="530" mass="59484" checksum="80FA820B9CFF899C" modified="2017-04-12" version="1">MERGRALTKGASPAVHLGSPSILLAPSEAFSKEPDLPSLSPVYAYEQDDSPRDVRELSVDIRLRLSPFIRPSTSSSSLSNLSSTQFAALEERNSLQSPLREELASDRAQLAEGLSSQSNMAGLIPLPEDGLFLLPENDTWAESSDGLPEASSQESESETDGESIGGDRELSLAYSEQVFPSAVEWIERYMGDEPACYRCRAPGLEHGSGWSMKDMAAWIRQSGLPDILNQSISDPLPPPHDPLWKTVLTGDPSVPPLSACPPHAANHTRNIRFDIDALIAEARSLAVLRELRFSYHPKPMHNVQKSIHVLFHGKQLHQCRHIRFAEGLHDQHLWLYIAFPRLECSRETYLTKSQHALWIDQIVLPSLREVMPPTYMQHLPLTWAHGAAKMRAKHNEHRTRDVGGTDLIPYAIKEEYLSELWERMRAKLIHPSLAEFRGMFIVVQTYGTKLVWNHENFTQLRNDFCRQLSSLLNLAYLDESKTYVDIGKECLSGPSNIHCGNAVVYRTGSVLWVSNIVWLRDCTLLAVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCW8</accession>
    <name>A0A1Q5UCW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCW8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCW8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="240"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="566" mass="63294" checksum="9CB30690727BD7C3" modified="2017-04-12" version="1">MIAARRPPHGWSESPLRKKIKPLPNLTEYPPDVPKRPLRPLAPKIAYSSGFIAQAQSPSSTTGRPYSPRASLRPLAPAPPRALHAPNPFIIETSCDQPAQQHRKCHTEQNQTGSQQIRLYPKLIDHTPTDPKRIQYLADQALAFLQQELNGRVEASNSFPSHVSLAHIRSAVARYEEAIEAVSKRAVCASCGRLFDATDIHSVVNEDPRLQLLHGKLDPCGQHQHFWNLCSTCLTSLSQQTIPKFSARNLVNVTFCQHYPSVLEDLTPVEECLIAKCHPVGIVLKLRPGGHSSPVSYRAIRGHFIVMPQDPEPLLHILPSPDLSLDNLIKVLWAGKHPPTDADLRPFLLVRKHKVLAALQYLVQNNKVYQDVDINHPMIDDWTDDFIPPELRDNLICLDEPGSGEREGYTLSLRTGNYENDLQAAQSGDFDAGESEPLITGSVSTDINGERQNPDKRLLNTLREFVSNSFQPGNEHTAQQCHVQHSTSCNGRNVPVIFYTIRGQITLLDQWSDPRYFTAAFPTLFPTGIGGHLEARPFPISLGSFMEWALRHHSRRSVLSTSTQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD14</accession>
    <name>A0A1Q5UD14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein SMT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD14"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="10001" checksum="851F2E4A61EA116D" modified="2017-04-12" version="1">MSAEQEAGAAPSEHLNIKVTDNNNEVFFKIKRSTQLKKLMDAFCDRQGKQMSTVRFLFDGTRVRPEDTPDTLDMADGDTLEVHQEQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDB6</accession>
    <name>A0A1Q5UDB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000327">
        <property type="protein sequence ID" value="OKP10452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDB6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718">
        <property type="entry name" value="OS01G0519700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47718:SF3">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="256"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="693" mass="78185" checksum="CFF2D54857616A61" modified="2017-04-12" version="1">MALLLPDPTLLPIALTLLPPGGLLPPPTNWLIPVPTSQEARALLNRYAALQGYAITVKNSNDWSAYLHCDRSGLPVKHDKPPSSGRSFTSRRCGCHFAAYLSKVQGGWLLEVREGSHSGHMASEPSTHPIHRRYQLKGLRDRVVRLFMEGRTNLEILDILREAKALDEGASSKSSADLIDPYRAPICLNRRDIRNLRYRARRELLKGCSPTAALLLGLDGWEIDWDAEAGSQRRIRSVICVSQSGLDLLARYPSLLWIDATYKTNRFRMPMVDIVGRSANGGTFYVAVAFVSDEKEGSYRWVLEKLCDFLHSRSIPLPTTTFSDDAESLLAALDAVMPDTRALLCVWHIQMNIEKRLRPMIQQHILVYLEMEGDVRPETNARWQSAKELFNQVIFAPTVYEMEACWKSFKKEFKHKVFAEAIQYITNQWMKDSMKQRFLRCYTNQKLHFEETSSSRVEGAHAYLKKFTKTSVGDLLSVMRAVRTAAKERHIKINQSLAEDRQKLPDNLLVPLFRLVLVDCTHYYRQALGLPCIHEILVALEGDEPLTRSQFHRQWWLLTSTEDDYQPLYLEQVLRINDPANVKVSGRPARAANHARKDPKVVAAKEAAIAAARQKIANACHEAATRRSTRLSRSTKRDPSGFEIVRNETDYIGRANRAKGAAKGVKGVKGVKGVKGVKGVKGVKGVKGGRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDU4</accession>
    <name>A0A1Q5UDU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDU4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDU4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="3">
        <location>
            <begin position="522"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="83716" checksum="D5C9C093BE278851" modified="2017-04-12" version="1">MPIRPLDEWAVGRTQSLPLSALKGAVIGLDASYYIQQHLVNQSTREALLGALGGFPFALKANIEKELQTFKNLGVGCIFVFNGLHFGKKDEKPRNQSAMVRSFEQAWELYDQQQADQVVDAFSNAGMTNLLARMSDIWSPSLPPKILDISPPIALIDTDDETSGTPPPETLYKFLQRILSQNGVSFMVAPYSACAQLAYLARGANPVIDAIYGPSEALLFDIDKLVTRIELEPAQFSWLTKQTLLEELGRLSNDQFLDFCLLLGSPFLRSFPLFENPAFPGKLPTVRDALPMFNAAGRSALALCAQFEDERRMQEPDYTKRYKRAYLVVKHHVIIDIDGRVGPMDQEHTSSDMHELIGLRLPEELYFYLSKGVLGRDVPNFLTSGEVRLSLPLGTEDTDVYRQLVADTLTPIRAQSIGLLANCLHRFYQTKIITIRPWFDENSEERQINLRELPSVKETIQAWRVSGDKFTEDVKQLQAPRGSFKFAIQSLNHPEFVAKTFANRETPILSKQDDILSNVMWRFLQLRGYVDDKHNLTSWGKCLEQALSAVDPADNLEDAIFIAIEMLRMNLLNTKHWFSHVSGGPMRGSEEDKTFNMLVSRVACIAKLQHKPIGYSGPLSRQLLCYRSLISEVRTALRNLIEVVLTSLLLSGEVDRDRNDWVELGIKLPFIDDNDCGLGIAVRTYLDDLPLQANPTSPEARQEVKSKGKEWFQHSESFTGNLDLAFKLWDAETKQKYLYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEW1</accession>
    <name>A0A1Q5UEW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase TIC 32, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEW1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="27542" checksum="74A09BF88DA319F8" modified="2017-04-12" version="1">MSGIFTYHNFSLQDTPYLEGQVAVVTGGQAGIGKEITAQLLLHGIEKVIVVARDENKFKTAYDEWRVRKGIELTQDDSRVTFVKCDLGDIEDVYAAAKKIKEQTEYIHILICNAANILFAKELTRRLQEDDDPGAKKVYVNSFSPGNVVTQQWQGWSEHLGRVVGVVIRGLGRWLGQSVEEGAATAVYLATSPEVSERGIRGGYFVPIAKGEEPTRLARDGDLAREVWDWIDDRVAQMLGENWQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFC4</accession>
    <name>A0A1Q5UFC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase andH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFC4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37638" checksum="DD1FC5A982C4122D" modified="2017-04-12" version="1">MASLENVLKNNVNLAEYGPGLVAVFVGGTSGIGEVTARALVRDTVSPRVYLIGRNEKQASKIIEELRQVNPKGEISFVYCDAARLKSVDEACKSIQEKEDKVNLLFMTAGILTTKGPDETDEGLDKKLSLHYYSRMRFLTNLMPQLTKAGTTADGSSTIPAQPGLYRNLSRVVSVLEAGGEAPLILDDLSLKKNYSLRNCAKHAITMTSLSMEHLAPVYPSTSFVHAYPGVVKTGLMRDFGAITRTAMSALFVLARPWMVPLDESGERHLYAATSPRFPPRASKDVEDAAPGSDGSKGSGAYLLHWDGSDNGNRKPLQELRKNDTGKLVWQHTMGVFESICGKTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFL8</accession>
    <name>A0A1Q5UFL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFL8"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF112">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G02370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="31436" checksum="D559D2170BA0E01F" modified="2017-04-12" version="1">MPDWTHLIRFIAVEDSLIHLGQLVDVTRDIGRDSVDGVEIAAYVIEGTIFDGKVTKDILHVKQLLSPVSREECNYIRCLGLNYTDHANEASMALPKAPILFTKPRTALIGPYPAAINVPKCAQDDTSDYEAELCLIIGKSGRDIPEEEALDYVLGYTASNDVSARNLQMLTTQWSFSKGLDGSCPIGPVLVAPSVIKDPQTLSIKAIHNGATVQDGHTKDMIFSIKKQISYLSQGTTLEAGTMFLTGTPAGIGFFRQPRVVLRDGDEISIQIDQIGTLVNKVRYDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFN0</accession>
    <name>A0A1Q5UFN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFN0"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="562" mass="62187" checksum="C2C171DD9AEBD5E2" modified="2017-04-12" version="1">MARTDPTLQDFLSPLKIDHDRLYRLSYRLSLTYRELAASSSEQFFPTATTRLPTGQETGRYLAVYLGLYYLRVAFIDLLGEEQIGKHPHVRRTLEKAWPIEDRLRRDHPDSLFSWIGDCIAEVIHDDLANSKDDAPAELAMGSRQNSVNEAILMPTGKGFALGSSLNLHQALLDGYECHTRRSADDDPAEMPAKRQKKYCLPKLKISVMTNDTISTLASLAYSIRALPNTRVVMGLLVGAGCNSAVPMKLTDLQESKIRHIREKDPDAVESVVSTEWTLRGATGPLQELDVVTKWDTELDTHSNRPGFQPLEYMVGGRYIGELVRIICYDWFKEIKGVPRSSMPVKLISEYALTTNFLSLVVASSYSDEKLAESLTRELPPPASSDWKWTPEYAGHIRAIAAAVQDRSAALIAAATVGLLACIREIELQDKDYPETKAKDSNGDPQESTQEQRMPDFGSSTPGWLKGPEELVVAVNGGVIQHYPHYKETVQRYVDRLVISAGPQSEGKSIFLREASDGGIIGVGVLAGTVAGDIDGIIGSTFERETEAEADMNAKARSVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG41</accession>
    <name>A0A1Q5UG41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG41"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="10190" checksum="F33C565577D6EBAD" modified="2017-04-12" version="1">MIYKTNYELYTTRESIDSRRSPPPDELLSPLATLYPHVAALQPQYNPDSCTFTGYRHTGYWASAYTTQPLEEPPFTPRRGSGLQHLLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG52</accession>
    <name>A0A1Q5UG52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG52"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21651" checksum="B35C16772B884FC1" modified="2017-04-12" version="1">MIDADAEPSPLPDPEFGRLDTTGWYPHYKQCVQYFLEAGQHNPSVQSIAAFINIRLPFQRPEDQQQQLQAQSQSQAQIHSPSFISLRPYVRRLIITAQDSPPIMTAFFGPDWPAGVGVLYKQERANYLFTAKSSGWAQTKAAYDILPDEQAPFLRPLRDPEEEEIRAAEARWSEWLAMEDWMVGARSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGF6</accession>
    <name>A0A1Q5UGF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="950"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1159" mass="122359" checksum="ECED045B54C130F4" modified="2017-04-12" version="1">MSAVGKAPKVGSKTGSPAKLRKASGSSAVSKPSNPETPAKSVKKTPAKKLTPKAPEPIQDDVDDVSVPETPSPKSKKRMPSSEQRRPRSPPDDAVSQASGSAAPLGKGASGLSKKAKDTAGQAKDTASKGAETVTNNVPLDLSALKGLSIADGGEVLGKDGTPLGKVVEGDPEDLVGQTVGDDGEIVDEDGDLIGRVDILHDVADQAKDIPDDAESKLDEAKNVVTDLAQLEGLPVSDGGVIKNSSGQVVGKIVEGDPEDLIGYTLNDDGEVVDDEGDAIGRVELLPVEEQEKNIEDAAGDVTEQVKGAHEEVDDDFEDAEDGLPTDKVKDAADNAADEAGDAVDDAEDAVDEAGDAAPDVDEAKATAEDTVDDAKDTAEDAVDEAEEGAGDVADQAEDAVDEAGDAAPDVDEAKATADDAVDDAKDTAEDAVDDAEDAAEDAAEEAELPIPDLDTLEGLTCNKRGYVIDQATGKPIGELIEGDPKKISRLKATLDDKGQFWDNRGNVIGKVKALPVEDENDEEGPFAGLEGLVVGQDGWIEDENQTRVGKLVEGDAKKLLGRGVDEDGEILDRHGSVIGRAERYDEPEPEEEAAPDVSVLDGMHCNKAGYVIGSEGFPIARLVEGNPKELAGKKIEDGQIYDGKKVVGRVELIPEDELESKSEGPFAGMESLVVTKDGFVEDDDGAIVGKLIEGDAKKLRGRCVDEDGEITDKYGNVKGRAEPYEPPEEEAPQEVDLSILEGKVVNKSGKVVDPATGAVFGRVVEGDKRLAGRKVDGKGQIWGDDGKIIGRAELIPGAEQEKAEGPFYGFDNAEVGKDGVVVSGDRIIGRVIEGNAKRLLGRKVDEDGDISDKNGNTIGKAERWEPEEKKRDINPMSGRKVNKEGEVHDADGNLIGKLTSGNLATLVGKTIDDNGFVVDNDGNKLGECTLLENIPEEEVEEGPTAEEQETQAKAEQDRQLAEKMCHILRQTLDQVKPVCKQITDRLEQADRTPKDELDEEKLVKDVKPLIEEGGRILQECNGSIRALDPDGRIAATAKARASTRDATPEEYQLAEMIKELTETVVKTIDNGKKRISDMPHAKKKLNPLWALLSEPLFQIIAAVGLLLNGVLSLVGRLLDGLGLGGLLNGILGGLGLDKLINNLGLGGLTDALGLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGJ4</accession>
    <name>A0A1Q5UGJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="464" mass="49789" checksum="E31A512BB10327E0" modified="2017-04-12" version="1">MEVSRRAPWLYNFRSSETFIVIVVSIAIFTDVFIYGMIVPIVPIALVKRAGAREEEALFGYFADHCRLRRLPFIVGLIALGASTGLFVIARSLPVLIIARGLQGFSGAAVWVVGLAIIADNVPPDRVAEAMGHTSIALTWGALLGPTIGGVMYEKLGFYGTFAIPGGLIIVDVVLRFAMIEESAVIQPVKAGMESAVDGPLYGTFGRQEDEYSGYFSSGEETASEQSHLIRASNPCFELPRLTYEKQATVLDLLRTPRLPLALIATVVMAIIFAALETTLPLFVMDTFKWSSSGAGLIFATTAIPSFAGVYVGKLISRFGARIPGTIAFVIATISWIAMRFVNSNTATDVTLLVALLLLQGVSIVFVEITAMTEVSQVVGDYEIEFPGAFGDKSPVAQAYALFNMAFAGGQLLGPILAGGIRVWAGWNTMTLIIGLVCGLTAIPMGLFSGAPLRDGDYTWEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGN9</accession>
    <name>A0A1Q5UGN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000275">
        <property type="protein sequence ID" value="OKP11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGN9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24051">
        <property type="entry name" value="ASKHA_NBD_LGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="436" mass="48053" checksum="9DD2B6404D2A6E07" modified="2017-04-12" version="1">MADSTGDQTLDLTVLGLNSGTSMDGIDCALCRFRQDTPESAMHFELLKYGEIPLESVIKKRVMNMILHNQTSPSELSEVNVILGETFASAVHQFCKDYNVDIDSIDVLGSHGQTIWLLSMPKPGETRSALTMAEGSFLASRTGITSVTDFRVSDQAAGRQGAPLIAFFDALLLHHPTKLRACQNIGGIANVCFIPPDSHGGVNETYDFDTGPGNVFIDAVVRHYSNGEREYDKDGDMGARGTVDQELVDDFLRHPYFGLDPPKTTGREVFRDTIAHEFITKAEAKGLSPDDVVATITRVTAQAIVDHYRRYAPKDLEIAEIFMCGGGAYNRNITSFIQKEYPNTRIMMLDDAGIPAGAKEAITFAWQGMEAVVGRSIPVPTRVETRQEYVLGKVSPGKNYRKVMRQGMLFGGGRDHLSPVTELVNYIDGKIFNNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHN7</accession>
    <name>A0A1Q5UHN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHN7"/>
    <dbReference type="OrthoDB" id="4297539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="227" mass="26338" checksum="BF09714F66E3E8DD" modified="2017-04-12" version="1">MAISQPLPPEEARSTCRCAIRYANNRKDTMSQLRDCRQNLINECIDPGTLRRDILAIATTETQLNYRRDAPSELEELYVPATREVFPDADAHMREKEIWENNEIHECYLRTWRCIKTTLLDIDEKLKCYGFVSAEKDKMIAMLEMLVVQIGRLRESLVGLIVVDRFADEMDEIAKSRGNKWSNNPELWAVWARFQRNMKCGCTACTPLNPEDCDDPVFEIPYLPLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI59</accession>
    <name>A0A1Q5UI59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI59"/>
    <dbReference type="OrthoDB" id="4364733at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="241" mass="26952" checksum="93A45133BD288477" modified="2017-04-12" version="1">MSSQYDGQAPENPGGEEAHYTAARNRQEALDGIHGLDNMALEYLIACANEVHPDLRAMILHSIHRVEGNRLSASPFRNLINAVWQSIHGRPSEGISSDENFLLAEEVANEIMATIRIIPVLCEEHANPETHFQALSALRQIGNMIIWAGPTELGLRVRGHFDGNSALERSMLGVVDQMTPVEKQAICNGRVDRWDDSPLLSKIQELQNEGRWCMLYDNMHLVIEALHDTSLPDDDEPDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX1</accession>
    <name>A0A1Q5UIX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000214">
        <property type="protein sequence ID" value="OKP12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIX1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="552" mass="63577" checksum="F2FA0E831704F65A" modified="2017-04-12" version="1">MSPSQMTDDIGVHKEHRESDTKVVRLTKDLAQLQRQRMVKELQVQIAEERLKLDEAQRYLDLVQQKIGLDRSDSISPQSPAVVTSSGQDLNSAVDALIESFSNPACKNERSVMNDTPTDGHASAYCKQETLTEHARIINGGVKRESPVPVVWSNGPESGSTLSKGPFNEENYYTETRKVQLGGKYIGRSLKNRWDDFIKTPGNTTWNSYCTFLAQQLSRRATPQQARYGITTARQKLAQPVTHFSLWLIQWAPVLPQVSTQSFMDYLLQGILPSIRDRIEMSSTQFSDYTSFTAYLQEVENIIPARAKIVRRRKQSAFSNDEHLVCTGTDGLKSSPKDDIMTQSTRRTRALPPKELNGQFKRRLSSDEPPQGLSVYSSRGWWEFKMFMSQLQHHLDKHGERFSKPQKIKIAMTNLSAALLEKWNEHAARLKTVTWFAFCVFLVNQLPVERSGRTRYYTMYQWCDQSVSTFALELLRWAPDNLSPNQDHMQHLWNRVHLEIRSEARRTWRDFADFHVFVAYLQQVQDSFSSPQQAEGHDSPQPRKRLRVSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ33</accession>
    <name>A0A1Q5UJ33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial protein import protein mas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ33"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="45542" checksum="E4801B2DFCC0AA16" modified="2017-04-12" version="1">MVKDTKYYECLGVDPSATEAQLKSAYKKGALKFHPDKNKNNPDAAEKFKELSHAYEILSDPQKRQIYDQYGEEGLEGGGAGGGMNAEDLFSQFFGGGGAFGGMFGGGMRDTGPKKARTIHHVHKVNLEDIYRGKVSKLALQKSVICSGCEGRGGKDGAVKECTGCNGSGMKTMMRQMGPMIQRFQTVCPDCNGEGEIIREKDRCKKCNGKKTIVERKVLHVHVDKGVRDGHKIEFRGEGDQMPGVMPGDVVFEIEQKPHARFQRKNDDLFYQAEIDLLTALAGGTIHIEHLDERWLTVNIAPGEVIVPDAIKVIPGQGMPSFRHHDFGNLYIKFDVKFPEKDQLQNLELLEQVLPPRPQKNQPPADAMVEDFELEDIDGNENSQARAHGAAGAMDEDDDDVPPGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJN2</accession>
    <name>A0A1Q5UJN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="74" mass="7566" checksum="0C807C3420A639B8" modified="2017-04-12" version="1">MATILQQMQAAGMTPADFPRNPPLTLTSNHSASSTFIASVAATGTVAPKGPDASESGDAPAQGAYTERSLESRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJN5</accession>
    <name>A0A1Q5UJN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-containing monooxygenase EthA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJN5"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="56109" checksum="EB144B48E9C1AB9F" modified="2017-04-12" version="1">MNGHANGQSEHRFDVIIVGAGISGINAAYRVQDQLPGFSYAVLEARHDHGGTWDLFKYPGIRSDSDLFTFGFAFNPWNRSNPIAEGSAIKSYIGDTARKFGIDKNILYKHTLTTADWSNEEHVWNLSVDADGKEKKFTARFVIFGTGYYNYKQPLQAKIPGLDAFKGQIIHPQFWPEDLDYTGKKIVIIGSGATAITLLPNLADKAARVTMLQRSPTYILSLPNRSASHWLSYILPSAAYQRIQRAVWIVTTRIFFLFCQTFPTFSKWILKMNVSRQLPKHIPYDPHFAPRYKPWDQRLCICPDGDFFKSLRAGKADVRTDTIKTVTSNGITLNSGETLDADIIITATGLQLQLGGGAQVSVNGEKYDPGSKYMWNGVMLQDLPNASFIIGYTNASWTLGSDATAQFVTRLIKTLDQRKLIAATPRLKPADAKNLEERPLLNLNSTYVTLAQRTLPRAGDKGPWQPRDHYHKDIKFALKGDIDEGMEFVAGPSLRLRPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJS3</accession>
    <name>A0A1Q5UJS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000181">
        <property type="protein sequence ID" value="OKP12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJS3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="212" mass="24278" checksum="5126D0390C34812A" modified="2017-04-12" version="1">MSALAQDSPDRSVMAIEPLTGSDNFATWKRLMTSYLKARQVWDVVSGDLQRPDCQFKYAKPITADISPLVEPHLNGAVRQRAIETRLEVEVQAFERHKEWSRREADAYHIILRYLSPNVSIHVAGLETSRDLWNELEERYRRMELATFCELFAQLRETTGDSCASAREFVDRVRLLVHRLNAIARGSIGDRTHIAILLTQIGPEYILIVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKF3</accession>
    <name>A0A1Q5UKF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044416" evidence="2">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="115" mass="12762" checksum="1BAD03C8ADEFE729" modified="2017-04-12" version="1">MSRTRTATLVSLSLFAAYAKYYQSFRNGFIGLLSDMADTKSLSGLPDGLHCEYTGFTPLDQFLTACNVFFWPVFQGEVPNLSLYGVAFASAVIPMWLVIVVETHRGRRPVAALME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKG2</accession>
    <name>A0A1Q5UKG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Extracellular endo-inulinase inu2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKG2"/>
    <dbReference type="SMR" id="A0A1Q5UKG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKG2"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="BRENDA" id="3.2.1.7">
        <property type="organism ID" value="16768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051670">
        <property type="term" value="F:inulinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000003">
        <property type="entry name" value="Extracellular exo-inulinase inuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012186064" evidence="6">
        <location>
            <begin position="16"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="8">
        <location>
            <begin position="362"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="54614" checksum="96578E4A0DE8348D" modified="2017-04-12" version="1">MFLALAFTLATRVMADDFRPIYHFVPEENWMNEPNGLIKIKSTWHLFYQHNPTANVWGNLNWGHATSSDLVQWTHEPLAITSENGVEAFTGTSYYDADNTSGLGSSTSPPYLAYYTGYFPSNGTQDQRLAFSVDDGVTWTKYPGNPIISATQESPHDETGGLETRDPKVFFHQASGKWVMVLAHGGQDKLTFWTSSDAKSWAWKSDLSADQVEGLPSGITGWEVPDMFELPIQGTNATTWVLIITPANGSPAGGNGVLALTGSFDGSTFRPDPVDPSTLWLDHGRDFDGALSWENVPVADGRRILASVMNSYGASPPTNTWKGMLSFPRTLTLKETSSKRYFLQQPVTELALMGSPLASIRNQTITTGQTLFSSIHGTALDINLAFTINAGAKLSLAVRKAASEQTIIQYDQTNSSISVDRTTSGDISYDPAAGGVHSASLEPDASGVIHLRVLVDTCSVEVFGGEGEVVISDLIFPSETSDGLSLEVTGGSANLHSVELRGISLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL86</accession>
    <name>A0A1Q5UL86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL86"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL86"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="27359" checksum="E70E286CFB3C230E" modified="2017-04-12" version="1">MTSNSLSHCCTTGSLHDGEAKGEIKNIGDISTYFAYPSNKSTEHAILILTDVIGHKFINAQLIADQFAGQGYFVVMPDLFNGDTVPLNRPEGFNIMDWVKNHMTLQTDPIIDAVLKEMRENLGCKRIGGVGYCFGGKYVCRYLKPGKLDVGFTAHPTMVEADELRGIEGPLSIAAAVRDFVFTTAKRHESEEILDSLDFPYQINMFSDVEHGFAVRCDLSKPRQKFAKEQAFSQAVAWFDQYLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULD9</accession>
    <name>A0A1Q5ULD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Apoptosis-inducing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULD9"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="551" mass="58410" checksum="E6F4498ED8FB0667" modified="2017-04-12" version="1">MAQEYKLIGLASLADVKSFDKIECEVDGVQDGKVLVVKYDGQVHALSPRCTHYGAPLKLGVVVPDGRITCPWHGACFNISTGDVEDAPALNALQKFDIFERDNAVYIRGTEADIKFGQRNPVTKCSVSNAEEKVVIVGGGSGTIGAVQALRELKYPGSITIISKEPEIVIDRTKLSKALIADPAKILWRPREWFTEAGIDIVNDEVTSVDFAGKSVKTASGSTIPYSNLVLATGGLPRTLPLPGFRNNELGNIFTLRYVSDVQAILAAADGSKKNIVVIGSSFIGMEVGNALAGKDHAVTIVGMESAPMERVLGAQVGSALQTNLEKNGVSFKLSAGVEKATSSDSNPSTVGAVHLKDGTVLPADLVVLGVGVRPATDYLRDNSAITLLKDGSLETDVHFAVPGLDGVFAIGDIATYPYNGPGGDGKPVRIEHWNVAQNMGRGVARAIVHARRSPLASLPAKSFIPVFWSAVGAQMRYCGNTIHGFDDLVIKGQLGEAKFVGYYTKGETVVAVVTMGMDPVMAKAAELMRRGHMPGKKAIMDGIDLLAVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULN7</accession>
    <name>A0A1Q5ULN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="50032" checksum="C5AFF72F03579EA7" modified="2017-04-12" version="1">MVFTGWPAPDPNFPPNESLQWALRTSKELSDYKTQAILLEELICRVEDPRPLFNELDQLYGHAKGDLIQFYESLTSQYLLATDEDSCWELLQRLEAAASEFKPTPKDDVCAATRWNGLGVQNALARSISEEEELLEQNSELAKTLSEALPYSQKAIDNPRWPDPHEARGQVNDRFKEDISHRLHKLELELLKYKRQALEKELHDVRSRLELEKFENEEKPRAKKEEIPKPREDTSGRGLGFLVQRPSSSPEISYNRKDDPTGEQDKQDGHKVKLRQPEDDAVEDTIPLTHEPEEINYDTSAHENKEHQTSEKPYRYASVAEPQDEPTTLDESGQDPAEPSRSEVRGRQTTELQPETAQPQVTSELAEDVIVEESIGEESVHSADGSEEMLAHVREEVPSEDERPSRPPSSLGRSSKRDSQDLENRSIRMIGYSEEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM64</accession>
    <name>A0A1Q5UM64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sterigmatocystin biosynthesis monooxygenase stcW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM64"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65947" checksum="B44BEF815EB257D7" modified="2017-04-12" version="1">MKRLSRVFSGSPKPVPEKEEPQQTPKTIIEGRSVDEGRPLRVVVIGAGISGILACIRFVQRIPNLDLCIYDKNADIGGTWVENRYPGCACDIPAHTYQATFEPNKEWSSFYATSPEIHRYWKRIVDKYGCMKYIKLKQQVEGATWDEENSKWHVQIQDMDSGSTYSDQADVLIQATGALNNWKWPNIPGLHDFKGKLLHSASWDEEYDYSNKRVAVIGNGSSGIQIVPGMLPKVTHIDHYIRSRTWVSPTFAREQIDKRGKGLENYNFTPEDIETFKNDHEAYQKFRKEVELELQSIHGATLTGHPMQVGAHEAFVTNMKRRLTNKPELADDLIPSFPPACRRLTPGPGYLEALTDEKVDIIKSDIVKVDATGILTADGQHREVDAIVCATGFDTTHTPRFPIKGRGGLTLAERWKKTPETYISVATDGFPNYFISLGPNAGLGEGNLLILIEREIDYFTECVKKMQRDNIRTLAVKADAVRRFTQYCDEYFAGTVFSSKCRSWYKGGTEDGRIIALWPGSSLHAMKVFANPRWEDFDYKYVNDNPTGWFGDGWTENEKHDKINVNYLDDDQIDFPQPVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMB0</accession>
    <name>A0A1Q5UMB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrogen assimilation transcription factor nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMB0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="643" mass="71852" checksum="F95BE96E962B2D61" modified="2017-04-12" version="1">MNRPTNQRIKQLEQENAILRQQCTRQGNTDVGIPERHALIPTEASLASLSPAQSRVTGSISHHAEPSPSDHHSSRGRDTSHPEVPDSENHRHSTSLYHGPTSTVYDDTAHSGADGEDSEGFDSPVSEEWARHLLFAQTARQRQLEPLNLAAGKLDFDGLDPEIGMHLLTIYWSRQLYTAQITYRPVFMRDMACDGPYFSKLLLNAILFTVSKHCPRPELRSDPDDITTAGWRFRQRFTELLRESFDKSEITTLQALIIMSNSLFSRCDERSLSWLYAGNAFNMIIDLGLHVLPSPNKMSAEELEVRKRVLWGAYTIDKIQCLLQGRPPLLRQINFKASLNFLDEYDELDTFKDITYSATEQRSAIPSLNVSLLTKLCELSIISERILCELYSESQNMSQSQSQKISADISSDLSKWRSSLPPQLDYISYPRESVLLPQAFCLLALSCVLTILSQRPLFMGSHPGCTRNSATAYEAVSMCTAAANQIVQILRDYSQHFSITTAPYMLSYATYISATIHVRIVAQKGRGSNSFQCLLLCRNVLREHLRLYAAAGKAMANLEKLVAHLGIVITEGDEAGTSMISLADDLPAQETISAPNLSNASDQTIDIGSPQLNWGLSDLDLEAIAQSFRLDSELHYLMHPVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMB8</accession>
    <name>A0A1Q5UMB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC multidrug transporter MDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_826</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UMB8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="849"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="28"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="366"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="737"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1078"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="651"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1047"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1322" mass="142940" checksum="77825A15AE67A8DB" modified="2017-04-12" version="1">MKFLQKLAGYPRLLLAGSPSKLDIGMLLTGLASAIASGVPFPIIGIIFGQLLDDFNSVTCDEKSGSSSSESNASYQSEINSKILLIFYLAIAQFVLIYAHLTCWTMYGARLSQRLRETYLQNLLRQEPSHFDHLPPGEVASRLSSDIQTIRSGTSEKVGIVIAAFSFFITAYIVAFIKYWELAAILLSLIPAYLLMSFAGSHYIEKYTGLMSDYAASAATIASEALNNIVVVQAFGANARLEEKFSRALRLAEHQGLKKAAAVGTQSGVLYFIAYSANGLAFWQGAQRVADAVSGDSAGVTVGSTFTVIFILIEATLMLSQVAPFLHLFVQAVASYAKLREDIDRQPLIDGTTTSGLRISEAEGGFEFKDVSFIYPSRPEIKVLDKITISLPAKKHTALVGLSGSGKSTIASLVTRLYDPTEGQIFFDGNELRDINLRDLRGFCSLVQQEPSLLDRSLLENIAHGLINSSNPSHEHLKDTLLSSTLAELALEVRDGKDLVTSAEARGPEVVEIVNLVQHAAALADADGFITRLQYGYGTSVGSSGRLISGGQKQRVSLARALVKDPTVLILDEATASLDSRSEQRIQNAINNISTGRTVITIAHRLSTITNADNIIVMHKGILVEQGNHATLMAKNGTYAELVNLQTLGSASSKDSSSIKDTASKSDTVSLTDTENEKIGLSDESLGKQEDTQVSATETPATDSSEEEPEPETPRKSLWALVKGYGPAVRPHLLMIFLALLGASIVGGAFSGEAVIFGNTVGSLNPCNGADSIRSRGSFYGLMFFVLAIIEFFANFASWTGFGWVSEKVVYSVRVLSFRSLFEQDLQWHQSNGRTPAMLLSYITRDGNALAGLSGSVIGSLFSITVNLIAAIILTHIIAWKIALVCLSLVPLLLGAGLMELHVLGKFEERHENAYTKSVDIGTEAITSIKTIASLSLEEETLKTYRRSLKGPRQETFKVTVLASLWQAITYFLGNCVNALAYWWGAKQIIAGTYTQTQFLIVVFSLLVSALLWSQMFALAPELSNARAAMARILSLIEIGSDGMQGKIRGPSLTESAEKDPEARGEHKPTISGGASSVQFRNVHFAYPARPDIKVLNGLSLDIRPGKFCALVGPSGAGKSTIISLVERLYKPESGGIIIDGVDVTKHQDVAFREAIALVPQESVLFEGSIKFNIGLGARPGHEATMEEIEEACKLANIHEVIMGLPNGYETLCGPNGNQFSGGQKQRLSIARALVRKPKLLILDESTSALDAESEKLLQDGLEKAARGITVIAIAHRLHTIRKADTIFLIEAGQCIDHGSHEELLERSESYRANVMHQTVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMS6</accession>
    <name>A0A1Q5UMS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMS6"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF29">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_6G10230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="353" mass="39153" checksum="5ABD62E6EF1DE2D8" modified="2017-04-12" version="1">MSECDQNTNTCPIPFSQRPIIILGAGIIGCAAARQLLLQGFHVTLVAEFLPGDQDINYASAWAGAAWHAAGSITPDQRYLQAVTHRVLLQMAREPASGVSLVDSREYLEQEPTPDSALWGRTVVSRFRNLSPEEYPSEFACAWAYETLVTDPTRHMPYLKRQIQTMGGRFIRRKVESLHELYGMFLDSRVFINASGLGSKTLADVQDDRCFPERGQNVFLRTDKCQTMYFRNGQEYTYVIPRPYSGGVVLGGVKHQDNLSPDVDLDIARDEIARAHRLAPDVVPANPPEDAISHIIGIRPSRKGGFRLDSEVQGSRTLLSAYGFGGGGYAFSYGVADALVKMVEQTERDHVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMY9</accession>
    <name>A0A1Q5UMY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein SYS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMY9"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="23410" checksum="2BD4ED00C80C38DE" modified="2017-04-12" version="1">MPGRRRLPAGSRSDLPPLKIIRKILLLQVAYYVCATVLILFTTIVYGTPFSFNLILGWDYLRGDTTVGWMLGLVWMLNCVISVIFLLLFVSRSKLVPDFALTIHFLHLVATILYTRSVPTNLLWWGLQFASAGIMTYLGMWACQHRELKPISFGGLAGLGGSSSQASSSQQPTSESNLESGFGRGRGRERSLQAGTGEYEMDEMKPGERTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN17</accession>
    <name>A0A1Q5UN17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="388" mass="43217" checksum="243ED6D0B42C6999" modified="2017-04-12" version="1">MYIFSSGLSCVCCLVIGFSQSLTGAVIMRSLAGLLSAVPSTIVGGSIEDMFNSQARIWVVFFWTVASNIGLIVGPIMSSHIIELLNWRWVFFTYAIIIGGITGLLFLIRESRSSYILTCEVDRMRREIPEIPPALNHDHSPNLQTFVKEALFRPAQLFFQEPIIFTIAMMISIAMSLIYIFTEALQPIYQSMGFSASQASLMFMALGLGTCLSTFTRILDCYIFNKRRMQGKPIRPEDKLVGLALGAPFLAIGLWWFGWTIPPKTPGPNTPWIIPTLSLVLVGYALTEMDTVLYGYISDSYLSYSASATAAVAFLRGMLSGAFPLFTNQMFNGLGANIAVSILAGVATVFCIVPPLFLCYGERIRRRSRFARYSWEIQEEMGKDEYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN22</accession>
    <name>A0A1Q5UN22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN22"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN22"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000034">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000023">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="538" mass="59103" checksum="AFC82F213076D499" modified="2017-04-12" version="1">MQAPVVVMNTNAGDRQVGRRAQLSNITAAKTVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVSHPAAKSMIELSRTQDEEVGDGTTTVIILAGEMLAQALPQLERNIHPVVIISAFKRALADALQIIEEVSVPVDIHDDKAMYTLIQSSIGTKFVSRWSDLMCGLALHAVRTVSFDVGGGKQEVDIKRYARIEKVPGGQIEDSEVIDGVMVNKDITHPKMRRRIENPRILLLDCPLEYKKGESQTNIEVSKEDDWNRILQIEEEQVKHMCEAILAFKPDVVITEKGVSDLAQHFLMKANVTALRRVRKTDNNRISRATGATIVNRVDDIQESDIGTRCGLFEIEKIGDEYFTFMRKCTAPKACTILLRGPSKDILNEIERNLQDAMAVARNVIFHPRLSPGGGAIEMAVSVKLGQLARSVEGVQQWPYKAVADAMEVIPRTLAQNAGASPIRVLTRLRAKHVEGHTTWGLDGESGNLVDMKEYGVWEPEAVKLQSIKTAVESACLLLRVDDICSAKSAQQAGNVGGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNL1</accession>
    <name>A0A1Q5UNL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNL1"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="16638" checksum="CCBB171C19A1B974" modified="2017-04-12" version="1">MTVTTTSTTTSASATSSCHAKLYDIPTHDAACAMPMRSNYSAIMSRCCSSASIIEYDSCDYYCLAQGQSVGDLAECLIKASEPGQVWCNTHANATATATATATGTGVVTLSAMGTVADSTSSATSSGAIASSTANAAGVFVPSSLSKSAIGMVGLLFAGSVMGHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNU0</accession>
    <name>A0A1Q5UNU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emopamil-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNU0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNU0"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="41"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="27475" checksum="74200E60FF3D035C" modified="2017-04-12" version="1">MTTTDSFTLDLTTALCIAFSLSFMPIAYLLSKALIPSTHTRNRILFFWHAYDALTHLFIEGSFLYQCFFSYASLPTGILNAGPHFLNRSDRVYGPAYGSGPSARLWQEYAKADRRWAGADLTVISLELLTVFVGGPAAVYVCYLLCRSSNEQLSAKVRGGAKATLWFVATALATAELYGGFMTFAPEWLTGSSQLATEDPVYLWLYLFFFNTLWVFIPLWVLWEAGKELQAAFVTQEVAVSEQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP51</accession>
    <name>A0A1Q5UP51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain-enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP51"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004795">
        <property type="entry name" value="PRK06143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="263" mass="28151" checksum="F0C06D0D8F73C1A2" modified="2017-04-12" version="1">MSLLTRLTHRATGTIAHLTISRPTKLNALNTPLLTQLPQAIHSLTSQNNDLLCIILTGAGPKAFIGGADIAEMAFLDSPASARSFISKVSEACRSIRECAVPVIGRVNGYALGAGLEVAVSCDVRVASRGAVFGMPEVRVGIPSVVEAALLPGLIGWGRTRQMLLLGENITADEAFRWGLVEKVVEPEALDDAVEEWVCQLEKNGPLAVRRQKALMRTWETVSLDEAIQAGVTAFGESFEGREGEVTEPARMLGAFFKGKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPF0</accession>
    <name>A0A1Q5UPF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_14120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="462" mass="51169" checksum="E334B3B8589BB9C6" modified="2017-04-12" version="1">MGRADDGYESVEEIKAFHSTLVSTFRTGKTKDIAWRKWQLKQLWWLVDENEQAIVDAIKSDLNRPGFETYLTDLAGIRKDILYHLENIDAWAADEPLGDSFVARRLGVARIRKEPLGVVLIIGAWNFPVLLVLQPLIAAITAGCCAIIKPSELTTACQTLLRELFTQYLDSSAIRVVCGGVDETTKLLEFPFNHIFFTGSASVGRHISAAAAKHLTPVTLELGGQSPAIIGKSADLDRAAKTIAFSKFLNAGQICLAVNHVFVDPAVHDTFVERLKHWSSQFLHGERKITTAIVNQRHWDRLSGLLKQTKGTVVCGGGESDELCRMKPTVVTDLDIDGGVTINDVILHAGFPGAPFGGVGGSGHGYYHGPYGFQTFSHLRTIMSPPKWFDRLLAFRYPPYSAANKAKMPKTKATFKRNETIQDQRVKKSRFLGLKIATGVALLGIFWYSRSYVNESLYAFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPJ6</accession>
    <name>A0A1Q5UPJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPJ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="157" mass="17627" checksum="FB39CF779DB62AB6" modified="2017-04-12" version="1">MYGGPLLHVNNTAKQSTIAKRATVVALKSYTTKWCTEITILTELSVPSVNRIYAKAIKRGFDPHRTVVDNEFVEDKPRSGKPTKQDPSTIDIILSKVRLDRYGREKTCADLASDLSKLEINISASTVRRILKKAGFRKTKPTRKPGLTKKMRAERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPV8</accession>
    <name>A0A1Q5UPV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000092">
        <property type="protein sequence ID" value="OKP14499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPV8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPV8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8926" checksum="D98829183E890F1C" modified="2017-04-12" version="1">MSRDGGKSLQSRCNEVVYWKIILKYVELLDPTTLPPAKAPNDGFSIAEKQSARKFMQDAGYGLAAENQRQYRIFWKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPY8</accession>
    <name>A0A1Q5UPY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13881</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPY8"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="693" mass="77878" checksum="546930680BDA2D17" modified="2017-04-12" version="1">MPSDGVLKRQKKKSIACRRCHTHKIKCSGGQPCNKCRQAGCPVECVYVNRDRQIKVHESYLDELAAENERLREQLSRSPGFGSPDGNVRSEDTPFHEPDTHVQNPMLGERAWFQPYDPSTPPVHIGEAACTAFATRLRQVLSKSKTTSHMPRTQYTPESTLMKIRNSEIQWPGLAQARLLIQIVFNQVSRVYHLVLRKSTIDELEETYRKADFDNPVLTCKFFALFALGEVYSTRSNVTLECGVPGAAYYVHAMMLIPILPERPSLTHIESILLLSLYSYFLNRRHSAFLLVGSAMRLGLTLGLNYDIPECQCPDPVDRQHRIRLWWAIYVFDRMYGSKVGWPIQITDDDIHVEMPSTVPGDVHDEQFSDTQFLVASIHLARITGQVIEKVYSRKKQPDSFLQREQKLLISLKQWAQALPPHVRLNRDGAGPKNVVSLHLQFNQCIILATRPILLYTLIQSRDADHTDQNTTQTHIQTLKTLSDACIHAARHNHSLIVAEWTNGSLPIMGYFYAHYLFSAALIMVLSSQIQSDNHADYALFETAFEILRAMRDHGNLAATEFYDNLKCVQQCLDKTQPTNVNPSAKRGSTARQSMTGESSRVPDQHPTDDALPVLPDQAAARRTNEVGLSGGSALPDTSGGGTFGNEMVFLDESMEQFLAQADVDFGPLDPSGVPISVADAVYSWPNFSLWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ47</accession>
    <name>A0A1Q5UQ47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ47"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="62260" checksum="4EF1EE24CC13E621" modified="2017-04-12" version="1">MSRRAPAAKKQQTLQFVTIDPSSDQGSSHIRRIVRSHAGGWIWRQLRDSQDNPQPDPEEEEEEDELEAGPSVREESQGRRQSTSQPRKPSPSVVGSLWEAPREFAPELVQRAGNGGRPMQLSRVSSEKLDPFQSYISTSPLPSGLVSNSNKYCLSVLWPGLMPRSSLIGGAPHAGIEGWFSISLGHPALHSAMLFGSYSHRRIMWLQKRQSDFSAEDEKQMAICEADSITRINLAIQNLSEALTDAIILCVLCMANNKNEPPLGPDNLESPFQAPLRSLQWLDVYGRLKPHPVHQIGLVQLVQLKGGLEKIKLPGLAGVIAFSGVLGASRLLSPPLFSYICIHEGEYLTLRDIIDSQHPVPTVDPNLIAELPITYDMQEIFRAARAYFALVDKYQDGIHVPLDTLADCRNLIQWHIMSLLSGSQLGARLIDAYPLYESCRLALVILGVSVIFPLPPQSAPLLELSRMLQAELQSTKDFAKVYSSVSTKLVYWCLVLGGIAATGSSERRWYVEEIRRLAGPYGLREWDSMKQDLKTILWLDRACDFGGRLLWEEALRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ68</accession>
    <name>A0A1Q5UQ68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="13541" checksum="0398F69F377E82D4" modified="2017-04-12" version="1">MDVEASLDLPIGQNGRRSNRAYLKAEMVGNRTKRIRDAKAEAQKEIEEYRNQKEEEYKKFEAEHSSGFKVAEEEANKEAEEKLKEIQAAGKKHGDKVVEDLIKATTDVKPQVPEKIVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNK6</accession>
    <name>A0A1Q5SNK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNK6"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO89584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="20739" checksum="E1E6F437DB0F4190" modified="2017-04-12" version="1">MSSPTKLPIRTQHCRFCNNLLLATTRSLSTLPRRSSPAADSALILPLEKLRTTDEESTSTSTQEPSTSTSPNARSSPKHVTILLSTTLPDRRATLIRREDGIEKRILLRCGRCRVVVGYYLDRVHWEGSSQAQKEKEKATREDSEEEGGDEERPPAMYVLPGSLVETEGMGGEGVGEKEWRVWGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNL1</accession>
    <name>A0A1Q5SNL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNL1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15366" checksum="793147729BAD00AC" modified="2017-04-12" version="1">MDAISSAASIIAVIQLAGTIVKLCGGYIQEIKDARGEIFTLQQVIAGLQGTLQDLHKLLQNNDRMATSSGLVNNIISCLSDLEALEARLNPGKGKKLMKTVGLRALKWPLKRTEVEGAIKNLERYKSLFLLSLQVDQRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SU88</accession>
    <name>A0A1Q5SU88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0674 endoplasmic reticulum membrane protein C2G5.01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SU88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SU88"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO91578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="431" mass="49478" checksum="19D770BF21A94A69" modified="2017-04-12" version="1">MAGMFKNVFGSQPSGAANPDDDFADFVEAPNPSPASLVADTTTIPAFSTGGAVPYTKWYRIWERTSPSDFMQEAIIMPFILVVVLFHLWGTRKNRRKVRDWAKAHIPALQKEFAVVGFDGISRSGPEEVTVELANPEKLLKEKSAHEFAAYATGRQNVAFLDIALTMPKRYNPITYIMEYVFSFFFETWEAPAEKYEALMYAFDGKEKDLVPVLAKESSSLKVANSTYDGFIWAVVHKSHMRKFRTDRYDASITFSKDHPKLPSWVTVMSESAEITDTLLTPELIQAIEQAGNDFEFLIVTDQPIDKPTKIDETVPKKRIQLSVNLSSGYESTLPLFNQFLRFADKLVSVAHWRGEVMRKIRNVRDEEIKKLRRVEEEEKAEERKLAAEKIKKEERERLLRGMTAEEQRKYLDRESQKGQRKSMKKYSRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUI2</accession>
    <name>A0A1Q5SUI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUI2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUI2"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000073">
        <property type="entry name" value="C-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="104"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO91620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="47148" checksum="F1FFBB2150EC8F85" modified="2017-04-12" version="1">MAPLSRYPSVSELVSHLNEVGRQKEAQLQKMARTQRDEQREEQRDSRLVPGPSSRPSNPNPPLIHPSFTQTTQAFIPEVKIQACFDAMGVSRSREESLRLSGVNWIHSVRKALHLPVRTFNTAVMYYHQFRLMHPDNDFNYVDAAAAALFIACKIEDTLKKSREIVCAAYNLKASPAELLTPDNPVFEAQSRGVIGLERLMLEASGFDFVTRHPQELLAKLIKFTYNIPPQSQVSHLAYLISMDLYRTFAPLKQTTMTLAFSCLELAQRLLDQHEPLESGADYETFRTSRAEVMETLLDLLELYTHSRALTSVGPDFPADQFLKVRIPLNQEARDKQLPRYNGPETPAPAEESGTRQRPLHPLTPLAANGDRRGESSRGRDAPLRFILDPAWAEQEGRQVSEFFKVETEEYEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUL7</accession>
    <name>A0A1Q5SUL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_13067</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUL7"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="100"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO91660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="53748" checksum="105B5A0E9E3E58BF" modified="2017-04-12" version="1">MAKVFDAAEVAKHNTPESCWVILYGKVYDVTDFLSSHPGGAKIILKLSGKDATEEYDPIHPPGTLEEELKPESCLGTVDPNTLPKDETPAKPQEPAAGPPPMQNLLNLDEIEEVATKQVSQKAWAYYYSASDDKFSKRFNTEVYRSILLRPRVFVDCTKCDLDTSVLGHKLGIPIYVSPAAMARLGHPSGEAGIAEACRSFGAMQVISNNASMTPEQIVKDAAPDQVFGWQLYVQIDRKKSEAMLARIKKLKAIKFIVLTLDAPVPGKREEDERNSLVGASAPVSSGVKAAERTADDTPDVSGSGGAGGVGQQLFAGTDPSLTWQETLPWLAKHTDLPIILKGLQTHEDAYLASLHAPQVRGIILSNHGGRALDTAPPAVHTLLEIRKYCPEVFDKLEVHVDGGIRRGTDVVKALCLGAKAVGLGRPALWGLAAGGPDGVRRTLQILVDETKTCMRLLGVETVDALGPQHINTRMVEQQIYDGPSALGSLRSAFRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW32</accession>
    <name>A0A1Q5SW32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LipA and NB-ARC domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW32"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW32"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="66927" checksum="7F9C85974DF226E5" modified="2017-04-12" version="1">MASTYLRPVPPPDGLQIRRKPVSNPNLRGTALAQAPGPLLHATTSPSLVPPPLSRPPSYNDLYGAASPAPRQDTSLRPRTAGASPSSARPSPSLSPSPTLSPSPSPSPTGVQKAFGEARHFLGGLINHPTESNKHVTILRHSHGLVFYRGNSTSVAVSIFSDTPLPQDRTVWLQNKGWSGKTGMRAKALFRLNDSWLDVTPGMPLRADQVNPDDERAWQRDIRKFLKKAPARPRDTHRLRETVVVRIPAEAGDGYFQLVLCQGMKKKVLGNSPVFRVISTSTSPHSIRGASLSTLPLEVGAMVVSLYAQTAAQTVMTPATTAINSKLNPYRPSWLTQAVAQKAYSASGIQERVAGIYNGSSAQPLKAQGDGGVVVPNHEVSPAELGPQNPFPMIFKARGQTGHLPSPSSPSDTPKLTLTDFPDWVSEQLRGYFFGWARFDMSTGKEKLTGPWCPAIISVRTLDPLQAARVNMSQLARHVVQLCLLDEVPVQTTKVEIRVMGFLRIDIPPPTGATSQELADAQAAAAEAAMLADAYDVSVVQSTLSHPAWAPEGPMWGEMDQQNTGWVDKTKQSYANIRAQGQKWVEQVPLHRLGVRSVADEWRERQVAVNGFYIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SX79</accession>
    <name>A0A1Q5SX79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SX79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SX79"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="55604" checksum="8FC01D4B1D4E6C9E" modified="2017-04-12" version="1">MPSQVTTCLRLARQFSADPAKHQLFLARNFSSSVRRAAINKVFASAEEATKDMKSNTTLLAGGFGLCGVPDTLINAVRANSSIQGLTVVSNNAGVDGSGLGLLLQSKQIKKMIASYVGENKTFERMYLTGEIELELTPQGTLAERCRSGGAGIPAFYTPAAFGTVVQTGDLPLRHNSDGTVALYSQPRDTKVFDGKSYIMEEAIKGDYAFVKAWKADKLGNCQFRYSAANFNGAMGRNAKMTIVEAEHIVEPGEIDPAAIHLPGIYVKRVIQSTTEKKIEKYTFAKEEGADTSALGKGDTASKRERIVRRAAKEFKNGMYANLGIGMPMLAPNFVDSSVEVTLQSENGILGLGPYPKQGEEDPDLINAGKETVTLNPGASVFGSDESFGMIRSGRIDLTILGAMQVSAKGDLANWMLPGKIKGFGGAMDLVSNPSATKVVVTMEHTDKKGNPKIVKQCEFPLTGPACVSRIITDLCVFDVDFTEGLTLIEIADGVTVEEVKAKTEAPFKVADDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SX91</accession>
    <name>A0A1Q5SX91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_12589</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SX91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SX91"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000059">
        <property type="entry name" value="Serine palmitoyl CoA transferase subunit LcbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="127"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO92604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="56205" checksum="71B3FC6AFF25F20C" modified="2017-04-12" version="1">MDLQETQRLLTEYLHELANLFHRVPGSAIFLRYVKSSYQDDPIRSAVELFLFLFAVRYLLAPKYSTKPGVVPLTEDEIDDLVDEWTPEPLVAQPTALEEMEVDKRMVIVGPVGPKSKLANGRTVNNLCSFNFYNFNTNESLKEQAIQTLRNYGVGPCGPRGFYGTQDVHMKTEADIASFLGTAACIMYSQAFSTISSVIPAFSKRGDIIVADKGVSFAIRKGIQISRSIVRWYEHNDMEDLERVLAKVTKEQARKPLTRRFIITEGLFESYGDMVDLPKIIELRLKYKFRLILDETWSFGVLGRTGRGITEHQNVDAAEVDMIVGSLAGPLVGGGGFCAGSEEIVHHQRISAAAYTFSAALPALLSTTASATINLLQNSPETVSQLREFTKAMRAQLDPRSDWVYCTSAPENPILILVIKPEVVTSKRLTYEDQQYLLQDVVDECLANGVLISRLKTLEDNFQPKQVVPAGLKVCVTIGLTKKEIEKAGTIIRHAITKVMSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXE9</accession>
    <name>A0A1Q5SXE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXE9"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="316" mass="35018" checksum="3ABF6A4500A739FD" modified="2017-04-12" version="1">MAEQLVLRGTLEGHNGWVTSLATSLENPNMLLSGSRDKTLIIWNLTRDEQAYGYPKRSLEGHSHIVSDCVISSDGAYALSASWDKSLRLWELATGNTTRTFVGHTNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKFTITDKGHTEWVSCVRFSPNPQNPVIVSAGWDKLVKVWELASCRLQTDHIGHTGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLHAGDEIHALVFSPNRYWLCAATSSSITIFDLEKKSKVDELKPEYVEKGKKSRDPECISLAWSADGQTLFAGYTDNKIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXP5</accession>
    <name>A0A1Q5SXP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXP5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7490" checksum="00665D0B936385D3" modified="2017-04-12" version="1">MALQMEESAYVIYETSAQLLAWEVCLMKEHILATRGKFTYIHTYLNPGIRPQPSWATELGSSLGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYL9</accession>
    <name>A0A1Q5SYL9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rpb7-binding protein seb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000729">
        <property type="protein sequence ID" value="OKO93073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYL9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYL9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="21370" checksum="444220AFF141FD81" modified="2017-04-12" version="1" fragment="single">PPHWKRLSHSPLRTDHNLPSPGSKLVEWDYSIGPGNIKVLSRTLFVSGISSEAYLRSLFNKFGIVQTCIVNIDKRHAFIKMISREDAGVGFGPRDCSDYQTSISVIPIERLTNADRKWLLTADYGGTGSRPIEFGMVVEEPDIEIGAGLSSKAISRRIAASTKRGRNSDGFGGGRGGRPDRNGFGSPSQGRLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ56</accession>
    <name>A0A1Q5SZ56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ56"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="523" mass="57071" checksum="69BD70783CC1CB01" modified="2017-04-12" version="1">MSSEYDEKAKAADSTAAEDHSGELINASGHVQELDRNFSLLSICAIAVTTGNTWIAQGGSVTVALSNGGLGATIYEFIAVSVCYWLVAASIAELASGMPSASGVYHWASVTAGKYGRPCGFFAGWWNCLAWILGAASMCLIMAQQTVSMYALMHPDFVPQTWNVFLSFIICAWVCCSIVLFMNRWLPFIGNIGMFFILSGVFITIIVCAVMPHVNGTGYMSDKDIWQNWQNPTGYTQQGFVFVMGMLNGAYSVGTPDCSSHLAEEIPQPSRNIPKAVLAQMSVGFVTGILYMIAIFYSIQDLDAVTGTGYKFPLTEIYHQATGTRGGALGLLIIAFIPTLITASGCFITAGRTLWTLSRDRATPFPKWLGRINSTFHNPFNATLTCGVFITILACIYLGSTTAFSAFVGCFVQLSSLSYFMAIFPHIMTRRSSFAPGYFFMNNKIGYIVNSLSCVYILAFVVIFCFPYYLPVDASTMNYASLMTGGLTIFVTVWWFVRQGSYEGPKNIPLNDKDVAHAAELAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ82</accession>
    <name>A0A1Q5SZ82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ82"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="383" mass="41391" checksum="059147C398073B02" modified="2017-04-12" version="1">MTMNPYLSWALLLVVAGGLGWYYTNGSTPKAKTAVRTVVEKTEAVVAPKKQKRKPKAPEPAVAKKPEVKTVVSPPTTEDDQPDEDVDRNEMARRLAAIKNGTSPALAPTSKSQKKKAKKAVQLESGSHASSTTGADADDDLSPAASPEVNATVPSAGYVSDMLEAPAPGAAVLRVTGNIESEPKKQKAQNFKQVETKKQRQNRLKNEARKQQVQEAEAERKKLLEKQLHTAREFERQEVSRSKPPTSNAWQTQAKPAVNGSSQSAPAAPAAAPVQLLDTFEPSAAAPAQKKWDQNLPSEEEQLRILESSNVDDDWTTVSSKKVSKKKGGKADESFSEASASESQPTPVAPLPVEPRVTVTPTYLPDILRSREKGHPLDSDWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0P8</accession>
    <name>A0A1Q5T0P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cutinase transcription factor 1 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0P8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0P8"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="53208" checksum="945896E53BAB8A21" modified="2017-04-12" version="1">MSRATVECLRVNGVLVLPSIQLQSALLQTFVESVLPSMPIIEWQQFLTIIRDGHGAHGSVSLLLYLAVMFSATTFVELEHLLKAGYSSRKEAHEAFFQRTKLLYKANYESDPLTIVQSLLLMTYRLDTADGQDSRHWIKGAITVARSIGLFQEASMIMNFPYSPKLWRRIAWACYMTDCVIALRLRCRAAIERAEFFHTLLTEEDFELYSLPMENQILPPECSLVRNVKAQKDLASVCISTAKLCTCISNVLDLQGKQNNHTALSPNSPSASPSDDYTGRICSSEMELADWANTLPPPCQACPVEPHSIDEEPTVILQRNILHMIFYTTVAVFHQSQPFPSSKSCVQLAANQISRITSELYQRNLQHRLPVVGITAILVALIIHVSEMKTSRSDERNEAIQNFQLCLDVMSSLRELYWEANTATAWALNVIQKVAFNSGSGYDCRFRERSSSSDSSLTESFGTAVPLMSISSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0T8</accession>
    <name>A0A1Q5T0T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0T8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0T8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="502"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="764"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="851"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="872"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO93879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="902" mass="100357" checksum="5535C52060C11B52" modified="2017-04-12" version="1">MANANLLRPYSSSPEDDIPDQIGSNGSTPTGIATPQPDPADKRLPSIMHNYFQVGSFSGEKANLPRLWSYLSKSSSVDPSPSQTPTQFSSTTTTTTTTHHPSTSSESFVMMEREDGEGLDKMEVMPTTNLPTPPHSLLQQESDEMDLASSLEQTDGPSIFHMLKKYLNPSTSVPPSRRQTSLPVSSVSDDPVLATHFSNPSIPSASSDAAFCPSEAPLLNHEMPHVSISSENLAKLTGNAPDGVRLKNTPPLTPRAMSNDDQSADKKSVTSAPRASESEESQEEQQRQEQQPHSDGMDSSTDEIAMKLDEAFPRQSSASPQNGAPVGPLKGKLFVKISEGRGLRPSFDPYVVCVFEWNEYISGGARSGEEEKKRRQMQSDAEAGIPMAIPMKSRQSSYNSALDGHDHKGRTPVTDPHWDHEAVFDVLGDQSEVDVTVYDRSNQEAFLGHVRLAINLKEDHSRLEGWFPLVARAAGDSQVSGEIHLQMRFEMTERRQVGPNDFHILKLIGKGTFGQVYQVKKKDTERIYAMKVLSKKVIIQKKEVVHTLGERNILVRTAMTASPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQREGRFQEARAKFYIAELILALQHLHDHDIVYRDLKPENILLDANGHIALCDFGLSKANLSQNDTTNTFCGTTEYLAPEVLLDEQGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDALSTEGRNFVKGLLNRNPKHRLGANGDAKELMAHPFFSDVDWEALGRKQVIPPFKPKLQSDLDTSNFDPEFTNALETNNSLHERAAALANGLMPGSTPLSPGMQANFKGFTFVNESSIDHHLKHDPADRMDEDPMHEESWQRTHRATNSNDQRMSGVQKTDGTEPGIFNVDDNFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T288</accession>
    <name>A0A1Q5T288_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex, subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T288"/>
    <dbReference type="OrthoDB" id="5302254at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8372" checksum="5EF1EBF5474D2731" modified="2017-04-12" version="1">MLRRKPTAIAITTEDIAAFEESRLRKQNENREPEQAQGSSAKTHVNPSDELKPLPGDKARILRREERIGLGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2N8</accession>
    <name>A0A1Q5T2N8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2N8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2N8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="48"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO94499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="555" mass="59858" checksum="16BA93A73CFD7EA1" modified="2017-04-12" version="1">MTASEEDIEKKGVTAVEPAGDRSMPAYDDVAVGTTQISPLKRSLQGRHMQMIAIGGSIGAGLFVGTGSALSAGGPGALLVCYLIVGGMLLLTVQALGELAVVYPENGAFFTYCVRFINPAWGFAVGWDYAISWLIILPFEITAAGITIQYWRDDLNVGIWIAVFLVILSAIQFFGVRGYGEVEFALGMIKVIAVIGFIILGIVIDCGGAPKGGYIGAHYWHDPGAFTDFKGFCSVFVTAAFAFSGTELAGLAAAEAANPAKSVPKATKQVFWRIMIFYVLGTFIVGLIVPHTADYLLNSSGANTKASPFVVSIANAGIKGLPSVMNVVITISVISVANSATYGSSRTLQALAARGMAPKFMAYVDKKGRPVYCILLQIAFGFLAFINEASSTGGIIFNWLLALSGTISFFVWGSICLAHVRFRAGWKHHGREVSELAFAAPFGVIGSWIGFGLNVMCLVAEFYVSVAPKDAEVFFENYLAGVLIIALFIVWVIYTKFNKDPKLDRGAWFVKVQDMDVFSNMRDTALDVDLPPKVVYHTWGEWFKAAPMRVIRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N6</accession>
    <name>A0A1Q5T5N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11068</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="37"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO95556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="419" mass="46161" checksum="CF86EA5E9ED8292B" modified="2017-04-12" version="1">MGSNGNPSVFTPAAVAAAPEDPLFGLMKAYREDPSDKKVDLGIGAYRDNNAKPWILPVVKKADDAIHNDPTVNHEYLSIGGLADFTSAAQKLIVGADSPAIREKRICTLQTISGTGAVHLGGLFLSKFHPAQPKPTIYLSNPTWANHHQIFTNVGLTLANYPYFSTKTKGLDFDGMMTALRAAPSGSIVLLHACAHNPTGVDPSQEQWKQIAALMRERRQFPFFDTAYQGFASGDLTRDAWAIRYFVEQGFELCVAQSFAKNFGLYGERTGAFHFVSAPGADASTSIQHIASQLAILQRSEISNPPAYGARIASKILNDPVLFAEWEEDLRTMSGRIQEMRRGLRERLEKRGTPGTWDHITTQIGMFSFTGLSETQVKILRDKWHVYMTKNGRISMAGLNTNNLDYFAEAVDSVVRETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T7Z1</accession>
    <name>A0A1Q5T7Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T7Z1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="34271" checksum="D5AB9927EB1DB970" modified="2017-04-12" version="1">MAESAASMSVNTRFLLLSDTHGLSSLPHSASIEYADVVLHCGDLTKESKLHEFKASIQLLKSVNAPLKLVIAGNHDFSMDIPAFRKKVAEAPEPLDSGILSKFYGSYGEARQLFNEETGITFLDEGIHTFSLKNGALLKVYSSPYTPSLGDWGFQYHPQYGHKFSIHDADVVMTHGPPRGIMDYTYSGQRAGCPTLFEAVARARPQMHCFGHIHEGWGAKLVTWRPKASAKPTHLTDIDNGKSTVIGKLSALKYQENIKPVSTTAYFRGDTHQLKRDGSQTLFVNCAIEDANALPTQQPWLVDLDLPLAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T856</accession>
    <name>A0A1Q5T856_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cutinase transcription factor 1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T856"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T856"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO96390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="33877" checksum="438E27608860D0DE" modified="2017-04-12" version="1">MSSACIICHKRKVRCDLAIHNPCTNCTKSDVECRPYTRKRKRFTNSLSPGRVLNSDSVSRRSSQLPADAPVESGGAPLSSFGDNAPPAVNNGEAAALPPSNGEPFIKEESYRGRSEYLGGSVPFDENMVRPGHETTYTSPKASAADLQMLREQGAFELPPLSVQNELMKSFNKYCAPWTPVVDPKWLDQSTPPSMLLLQSIFLAGSRVSKAHLEYGSSEVFYRRAKLLFFFGGRNNSLISIVAACLLHWYNPVGPEDVSTDTSGFWIRTAGAMAFQIGLHKEPPPNAKDRGLRRRLWWSLVVRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8H0</accession>
    <name>A0A1Q5T8H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8H0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8H0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="272" mass="30009" checksum="092097F7829C5382" modified="2017-04-12" version="1">MTHKQRAKEENSDVMGTLTMASASIEVYESTNPAKSDSEAVEVTPASQCLTCVDLENETKEPAGDIVDVEIKVVEAKSEDDRNQKPVASLYCPRNGRSHATLLDFGITECPKCDQGLISRRHQPYESDESSTSSDDEGSVAASEDQENDNTSPAITYSLEYRDAGNYHIGTVPWAGPFDLSAARKDLKEKERVICDVVTVLDTSIPEFSHRHPSEKAEILEKGILGNSNIQLKVSSTKLAIRSKALLRVFATVVTYYPEENLQRDLLDLNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8Y4</accession>
    <name>A0A1Q5T8Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8Y4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8Y4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="283"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="528"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="696" mass="73176" checksum="767188264D0E76EF" modified="2017-04-12" version="1">MASPRPHNFGAQGYPLANGATPSGPAPGAVPLLPNNGRLIQSGPTRILCIADVRGNLKSLNDLAKQARADHIIHTGDFGFYDDTSLERIADKTLKHVAQYSPLLPENVKRTIAQVPPQQSIKQRFTPDQLPLSELPMLLDKRITLDVPVYTVWGACEDVRVLEKFRSGEYKVNNLHIIDEANSRLLDIGGVKLRLLGLGGAVVMHKLFDNGEGKTTIAGGQGTMWTTLLQMGELIDTANRVYDPSETRVFVTHASPAREGMLNQLSVTLKADFSVSAGLHFRYGSSYNEFSVNPSLDHYRGKLAASKASFTDVWETVRGEVESAISSNEAQKTLLDNALDVVQKMPSIANGGNPFGGPVAAGNAAGQVDESAFKNMWNFNLADAAFGYLVLEIEGGRIATEMRAQGFNFAHRSGKPAAGGTQPVPSALPATTASPAPTGAGGRPTASTPQFGQAPPVLGGAAAGQQPGQAKAQPARASPVPVIPKAASPAPPATTSAQPAGEEKIAGADANGTIHQEKTGDSPAPRGEKKPSNGLFVSNVDSEQKVRDLLPEEDQAKAVKIEKYGKFNYVVTFPTVEDAKAALDRQPLDHKKPTTGSGPRKPNFKFFEERPRGQGNAGTWGSSTRGGATTGQRGYQSASDSEGARRGGFGGRGRGRGDRGRGGRGGRGGSFKSGSTDSPAPSTPSGDKPAPSGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAH3</accession>
    <name>A0A1Q5TAH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAH3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAH3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF178">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18227" checksum="31A58E28E0B6BAC5" modified="2017-04-12" version="1">MASGDDLFLDVPGTVYLVDASRTLNDAAHAGNQDILLIPQPSASLADPLLWSLFLISAYACVFSFGENNWGASWTLISEDTGVSLTNMNGGSALNYLLLGFFNIIWIPTAMKLGRKIVYILSLVILLGGSVWGGFYHGTAQYYIMLAIQGIGTAAYQALIQLTVHHHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB55</accession>
    <name>A0A1Q5TB55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Programmed cell death protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB55"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB55"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="37080" checksum="2EB42140159A670E" modified="2017-04-12" version="1">MAYNKSYNPDALPAHAEPEQVAQMIGNMQMSGGHGQSQKPLPSRPPPQSASSGGVPSRVPVSNSPPSHAYNNAPPANPYNGRPSPANAPPPNQGQYRPHPLHPSPPPQNYGFGPPPSQQQRNRPPLASRPPQSPQPPPLTAPTDDPQQLFPLFRAANSSHSGSLTEQELGSALVNGDYTSFHPRTVKMMIRMFDRNGNGTINFDEFVSLWKYLAAWRELFDRFDEDRSGRISLQEFENALVAFGYRLTTKFVSVLFTAFESKTRQVNAPSKSPGQNGMSFDLFVQACISLKRMTDVFKRYDEDRDGYITVSFEEFLTGTFSPTELNASTRIAAVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCF4</accession>
    <name>A0A1Q5TCF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="515"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118321" checksum="DBD4AEC92983739F" modified="2017-04-12" version="1">MLNEGVFSGHPHVKLFVWHASGSQRPTFKEATDPSNHYEPAALGQQFGPSWSTHWFKVYIQLPEAICSKDHVELHWDCNNEGTVWTEDGKPLQGLTGRGERIEWIIPSSFKDGNQHLIYIEMACNGMFGNGPGRPIFKNNPGGDSIQPPDQNKLFALSKAEIVAVNLDARMLYMDIIAIHDTATVLPEESWQQHKALSVGTKIMNNFKLGDKNSIIRCRKIAEEFLGPQTSSSDIYSTGHQQDADVFAIGHCHIDTCWLWPWAETKRKVTRSWLNQCDLMDRYPELTFACSQAQQFQWLKEEYPYAWERVKEKVQTGQFQPIGGCWVEHDTNLPNGESLVRQFLYGQRFFEANFGSRSRVLWLPDSFGFSAQLPQLSRQAGMPHFLTQKICFNNINQFPHTTFNWVSLDGSQVLCHMPPVRTYTAECTVADVQRCVTNHLSMDQDYTSLMAFGKGDGGGGPTWQHLERLRRCRGVSDTVGLLPRVHVGGSADDFFRRLERKSDLFPTWTGELYFELHRGTYTTQSSTKKNNRRAEFLMRDIELLATVASIADSSYRYPKAEIDQMWQKILLCQFHDCLPGTAIRMCYDDSDQVYADVFKTGENVLRVLYQQFNLELLEANQSESQHTVALNTLPWHRKEIVRFSGDSCLIASGNGNLLALERMSPVSTERPVTIRELSAGVFKLQNAQLSLTVEKGCIISLNDRKVDRELIPLGKKANQFVVFDDKPIYWQAWDVEVYHLDTREELESSSTSITEDSYHRVSVTTETVISSKSSMRVTISLSATFDESDYSSVECTAEIDWHENMKFLKVEFPVDIRNTEASYETQYGTVRRPTHYNTSWDMAKFEVCCHKFADLSEHGYGVSILNDSKYGFATVGNVMRLSLLRSPKAPDDTADMGKHTIRWAIMPHAGALGARTVRAAFNFNNPLKLLVAKPKSPMVRQFPITLKGDDSLVLDTIKRGEDDEDISTGELPTRKGRSVIIRIYDSLGGRSRGTVQTIWKVSKVVRTNLLEDDEEEVPVDEGVFKVDLGPFQVCTYRLCLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCR6</accession>
    <name>A0A1Q5TCR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCR6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCR6"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="65"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="54955" checksum="F438A0B1E05AE3AC" modified="2017-04-12" version="1">MSTTTATTSCKLFDHATIITVNGRREVIRDGYIRIDGDRITSVGKCPYLGELPLDAERIDCDGKIIIPGLINTHAHLVQSLLRGLAEDLPLHGWLCDAIWPLEASFQGDDGVRAARLTMAEMLKTGTTCFLDPMLTYRAGFDAICEVAGEMGIRGCLGKLVKFTETNRQLSITDPRDRDLLAMSIPELLKAHQSHHNSHGGRVQVWAAAGTPRGTSISHYLKLGETCARHGISATMHCAEAPRDRKIYRDTYQCSAMEFIRDAKLCGQKTPSDQGLDQLSHRLVLAHMVNLDEHIDIPLLASTQTSVAHNPSSNLKLASGVAPVPSMLSAPSPVNVSLGTDGAPCSNHYDMFQEMHLAGILHKGVQQDASLIPAEVALEMATINGAKALGLEHEIGSLEEGKKADFVVVDPYGAGGLGAVPWSSRSSSSAVSPVTTVVHGCTGRDVDMTVVNGVILVRDGRLVRGGRSEEMKIIHMAQEAVEGLLQRCNHGREQGQEIGGKLMAPWNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD70</accession>
    <name>A0A1Q5TD70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD70"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="15633" checksum="877289CF78EFF950" modified="2017-04-12" version="1">MLKARCITEHRTTVRSIDISRDCLTRNFVPSNPAKKVIRYWVKTQKAETSNNAYALAVDYGHSRRNKQFLAEADFEKVSFVKANPVELGSAALSVALHSLCLGVEATQPAHEVGQYGFGEPAPLLTRQGQTVLMKAVVSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDY4</accession>
    <name>A0A1Q5TDY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDY4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019996">
        <property type="entry name" value="Salicylate_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03494">
        <property type="entry name" value="salicyl_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF48">
        <property type="entry name" value="ISOCHORISMATE SYNTHASE MENF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="5">
        <location>
            <begin position="115"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="42843" checksum="25025992B27EE08A" modified="2017-04-12" version="1">MGSKQISRSIAGSSISALAREFVDENLKTGGKIFGQAGFNYAAHIRRQEFKPGQWPLLSLLVPSIDLTFRRDEITIAGFDDDRVRELHDFIHNHPANFDRAHLKTTARIDTQENPEEYISRVEKALLEINRGNYVKVIPSRAVNIQDKVDMPATLLLGRRANNPARTFSLNHAGFQATGFSPELVMSVQERKVITEPLAGTRSCNGSEAEVERLRRELLNDPKEIVEHVISVKEAIEELERLCVPHSVTIDDFMSVRIRGSVQHLGSRVAGILSPDKDMWDAFEILFPSITASGIPKHTAIQAIQRLEHQTRELYSGAVIMIEDPECFEATLVLRSVFQDATRQWIQAGAGVISQSNPQRELRETCEKLASIAPFVVMESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEJ6</accession>
    <name>A0A1Q5TEJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybenzoate 6-hydroxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEJ6"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="410" mass="45523" checksum="7C390D24FEEFA5AE" modified="2017-04-12" version="1">MPSRTDSPLQVAIIGAGLGGLAAAVSLRRQGHAVTVYERYDFAGEVGASLSAASNGSRFLEEWGVDVKAAKPVILKQLIMHNWSDGEVQSTYPLGDYKSKFGTEYNNFHRIDIHKQLLKSAFEEPGDGPACALKVNHKATEVNYEQGTIRFENGSETTADLIVAADGIRSLTRNLIGVVPQFEMSTSCCYRCIIGADKLRSLGLEDYIDNEAIEYWGGFGINKIVMSPCSNGEVVSCYCFYPASVNNLREDGWNIGATPQQLVDTFPDLDPQMKTLMLNAEDIKMWRLYRHQPYPYWVKGKVCLLGDAAHPMMPDQSQGSCMAFEDAGALGIVFNKNFREYYSVSEGLALYEKLRKPRATKVQEASFRAREDLNERIGWSSSSDRPGKLTIEEVCGYNMRDHLAELMAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEW0</accession>
    <name>A0A1Q5TEW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEW0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEW0"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="283"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="817" mass="90495" checksum="42716B2C77A007C2" modified="2017-04-12" version="1">MAPILLDSNNADTQSNGVSKLQEPRSGLELVLNERWQSLLYLIEALDAPTAIKDEHFDVQLQRVLQLAWVVTMRAFASSTTLYVGQKYLKGQCFVGETQDCAESTTQIHVDTYETLQNLFAQMIKSLEAISPKLLTTHVNGFSKTVDARAMFNTTIIYRQQPIRGSENGVKACMNRCHSCCPQAISEYLDDEVPVSGLRLDIQRTTNNHLVARLDGGITFSNPPLATSLLRSFNQALSSIVSLPKQSIGTVELCSMHDREHISSFTRSLAPAQDALLHDLCLRHATTTPDALAVRSWDGDLTYLQLNDYVCRLAHWLSGKGVAPGVFVACTFYKSTWAIVARLAILMAGGAYLCVDARDPPPYLESVLERSRIQIMLTSTGFAQKYAKKVDVHFEVSESSLQALPSFPDNPSSTVTPNDACVVLFTSGSTGNPKGIIQEHRSYASALTDYIRVMGMGPHSRLFQFDAYAFDISNNDLLAPLIAGGCCCVPTKSMTIPALMRDLDELEANIMFVTPSVAVEMDPDLVPTLKTMCIGGEPLSDTVLTKWMSRVRVINQYGMGEVASLCAHNPNLQLGRGAVVGRPASGAIWIVSPDTPDQLMPVGAVGELLIEGPHISRGYLDHVSGKSENFLATPPTWMAQIHSDRPSHRFYRSGDLGRYNHDGTIELIGRKDTMLKLDGARVEAGQVEFVLRKHLSTGDVALVDVLGTVDGVSERIIGVYLYLANNPMNFEEGPVEEMQFRAIKDRHAISSLTQAMSNEVRQSLPRYYIPSLFLLIERVPRTKSKKTDRRKLHMLGQAYYMAHREELKDIIHWPEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF58</accession>
    <name>A0A1Q5TF58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smad nuclear-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF58"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="323" mass="37966" checksum="B3CC3FC8F08B6F08" modified="2017-04-12" version="1">MAGSQEDHRDRRRRSPSNSSNRSRERRRDTRGEYKSSRQRDDDRRSSRRDSSRRRSSRSPSARESTRRDQDRIRRERRERSTDRADEDRRRDRHRSHRHRDDRDRDRDRERSSRRHRSPRPRSRSPRRSQTPPRAIQRRGPLPSQSDAFTGELVQSGDAPPPEKIKPNFNQTGRLAAESNTIQVQGGEGIVLKYHEPPEARKPPAKEAWRFYVFKGEDLLEVVELGERSCWLIGRENRVVDFPLEHPSCSKQHAALQFRYVEKRNEFGDRIGKVKPYLIDLESANGSHVNGEAIPAGRYVEVMDKDVIKFGLSTREYVLMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGB1</accession>
    <name>A0A1Q5TGB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGB1"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="32346" checksum="C5107BE1DBAD3D79" modified="2017-04-12" version="1">MEFIFYYYTPSTAAAVIFTVLFGLSSLLHFYQLVRTRTWFMIPFLVGAILETIGYIGRLLASFEAPDFTKGPYIMQSALILIAPAFLAASIYMTLGRIIYMLEAEKLSIIRVGWLTKTFVAGDVLSFLMQASGAGLMVQGSNPSTGEHIIIGGLFVQIIFFGLFTISAIVFQYRIAKAPTTRSIELKGLWNRHMIALYTASILILIRSVIRVVEYLQGYDGYLMKHEVFLYVFDALLMFITVLVLQYEHPSEINCLIGRGQKYSEKVIWTREFVPASALEMGRSGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGC2</accession>
    <name>A0A1Q5TGC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair and recombination protein RAD26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8659</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGC2"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="368"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="700"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="886"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1026"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1147" mass="129036" checksum="56A3DB95C560E2F1" modified="2017-04-12" version="1">MASPNSTNAAAEASRLQELNADVRNQDDLERDITRQADKFLAEKAEENDTKRLDKALSDKDKVDRQIRQAKDRLAKHVGAVSRHRVENELRNLEARRSGLVNDIKDIQKRIDDRREAQENAEGSHGPGRLPNETRNEYLLRTGKITPFELMSKPGADGSLATLQDALVDAEDQQQEEEERKKAHHDPNASHRNLLRPELDFDETSESAESRSSKRRKLESPAAKRGPTAPRARSPTSPEADSEASYVASEGSVSSEDEEFMPDTVPEPKTRKRKQGKAESELEDLSGVDDGNEKIYQARLQKWISRRSAARNRAQDTPIKEEEDEVENEWLKPHPTEPDLDLQNGLSVPGDIAKYLFSYQRTGVQWLWELHQQSVGGIIGDEMGLGKTIQAISYLASLHHSNMYTKPAIVVCPATLMKQWVNEFHRWWPPFRVSILHSSGSGMMNVGRESSRETALMSELMGSSHSRHLSAGQKAAKKIIKRVMEEGHVLVTTYSGLQSYADALVDVEWGCAILDEGHKIRNPDAGITFSCKELRTPHRIILSGTPMQNSLTDLWSLFDFVFPMRLGTLVTFKSQFEIPIRQGGYASATNLQVQTAAKCAATLKDAISPYLLQRYKADVTSDLPQKTEQVIFCKLTREQRNVYKRFLGSDDMVSIIRGRRNSLFGIDILRKICNHPDLVDRQLHAHEPDYGNSDRSGKMQVLKGLLEVWKDTGHKTLLFAQTRQMLDIIQKFVGSLGGFNFRRMDGNTPIKDRQTMVDEFNKDPNLHVFLLTTRVGGIGVNLTGADRVIIYDPDWNPSTDMQARERAWRLGQKRDVTIFRLMMKGTIEEKIYHRQIFKQFLTNKITRDPQQREGFQASDLYDLFSLAEENDKELETTKLFKNADVTYQEEDSTTPPLKKRGQGGKSKSQTPNPDGEDISTVQGVANVEEFTNDAENQDGKKSAEDRIMHGIFARSGVHAALEHDHIVNGKRTVRADQKMIEEEARRVAAEAARELRRAEEVARSTPIGLPTWTGSFGIAGRTDVGGSSSSSRPAARGPSSSSLLSNLNPGASAAISRTPTPQGTGTPNRMPRGKDFLPLIRDFLLSRRGPVFTQVIVDQFNHYCTNPQRVAEFQEMLKTVARLDRDRGGRGRWTLKPEFAKKSADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH28</accession>
    <name>A0A1Q5TH28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH28"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="263" mass="28887" checksum="7FAEB7BB47E9B62E" modified="2017-04-12" version="1">MKVLCLHGKGTSGAIFRSQTSSFRSRLADQDIEFDFLDGPFESSPAAGVDLFYDPPYYSWWQQNGSAEEVRAAVAELNEYIEENGPYDAAMMFSQGCVLGSAALLLHQEETPHLPAPFKTAIFICGGPSMSILEELGFHISAKARERDVTSRDALTKQAGNSAILTQGAARWSGLESLNGDLSEQQLRNEIECPFRIAIPTVHIYGSRDPRYAAGVHLSAISTPERRKTYNHEGGHEIPRVKEVSDTIAELVRWALAEEPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THH3</accession>
    <name>A0A1Q5THH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THH3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="228" mass="24677" checksum="A694F28E0154375F" modified="2017-04-12" version="1">MINLYKAGRRVVKIAGDIKAIHAGYQASSGIVNEVSSLRTLLFDQDGNASLLFIPAMLFPDERGHPMLPLNAFVGVARASHQALPSTKVSVLIYATLGASRVSFPSVAIPREGTMTGPQYRGLLLSIFNKQRDAAELPALTPKELAIGPIESLPSTILDERYPGVPLPTVKFTLRAAFPVICFVMPGLLLQQNFIVAPNLHGFTCCFRLPTLAEREGFGLTVDFCPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI14</accession>
    <name>A0A1Q5TI14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall integrity and stress response component 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012050172" evidence="3">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="303" mass="31120" checksum="7A0746DDF7707FC5" modified="2017-04-12" version="1">MQFVLMLLLALALLARPFAEAASSLAYCATDNTGSSFSAVSDTYQSNGACEETCADYALGILQGKNCWCSNVAPSSSSRKSTSECSTGCPGYPDDSCGSASKGVYAYVKITGNSVTSTEGGSSSSTTTSSTSSTTSDSTTPTGSVVKETTSAGEVKTITVSAASQTGVQDSSSANAAATGSSKLSGGSIAGIVIGVIGGLALVGALIFLVFFYRKRARSASPIPSTADMTENRNSQASSFARGIFPQGHSHDLSGSSSLGRKHTFTDNRLKTDIYPNGPRDSSVSLQDNEDYSRPVLRLTNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TII9</accession>
    <name>A0A1Q5TII9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TII9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TII9"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="25589" checksum="198A6A4D77E5FE3C" modified="2017-04-12" version="1">MSQLQSLYQYIWLPDHLATHYDWLKFTEPTWNLTTYRITYTPKSGASFPAIVELITAAYLKDKFYKEHEYLLGKSRLGRGRTVTEDDIAVFDEMWAKCEPRVIQDAKQFGGASIDDHTRCHFEGWVEERDMADRFPDYRMFTVIDEESLQSLLSGPVPEERQVGMQYRIGHYAKLVEAWQEIYPPPFMGWMKCSLPGLWDIWRNMQDGCYMKDSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKA0</accession>
    <name>A0A1Q5TKA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000644">
        <property type="protein sequence ID" value="OKP00652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="128" mass="14475" checksum="5514CF18F4764813" modified="2017-04-12" version="1">MAKQSTQADRVTVVALRAYTTKTSSEIAKIVGLSIATVNHIYARAIERGFDPIHTKITDEYVQDSPRTGRPTKQDPETVNTILSKVRLDRYGREKTCADIAGRLVYGKRRFTENEADEEAWTDEEDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMB7</accession>
    <name>A0A1Q5TMB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMB7"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="126" mass="13978" checksum="062C6A20A42AA07E" modified="2017-04-12" version="1">MSSQPLLQTAPGKRIALPTRVEPKVFFANERTFLSWLNFTVILGGLAVGLLNFGDRIGRISAALFTIIAMAAMIYAVVTFHWRAQSIRRRGQSGFDDRFGPTVLAIALLAAVVVNFILRMRDNELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ75</accession>
    <name>A0A1Q5TQ75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="52" mass="5633" checksum="C04F624920A848F8" modified="2017-04-12" version="1">MGPFGDENELHDFLMGLASGHGFDTTAEYIKALAQANEIQKCPHKSLSPMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU85</accession>
    <name>A0A1Q5TU85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU85"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF1">
        <property type="entry name" value="ION_TRANS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP03763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="339" mass="37004" checksum="ADF6CC4FAC684E3F" modified="2017-04-12" version="1">MPFTQLPPEIILQIASWIDSESDLASLAQVNRDIYNTLITELYLRNAKNPKKSAIIIAARSGNCSALKRALQAWTVARGPSELPTSGGPSKYTPLLSAAIRGHLEAIRILLEYGVDPNERDRSMRTPLNAASTRGHTAVVEALLAQPNIKVNAYDTDKQTPICGAARNGHAEIVKMLLSAGAHAGFVRKTGWQTPLHSAIRHKQAELVRLLVNRDDVDPNALGSNGTPLETAVEANEEDLVKILLTDKRINPDLTTRSMFRTPLLEAALKNNDAMVRLLLEAGANKEIQDSTSLSPAMLLDAPSAEARHELIRERSLTGIKDHDASVLRMLSSRDLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0I3</accession>
    <name>A0A1Q5U0I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0I3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="8101" checksum="E04D97581662DF80" modified="2017-04-12" version="1">MSYLESIDQEKFYSMMNMLLKWAWPIALGGLNEEEEIPVVIDLPTNVQQDTEEPNEEEPDENNDDWVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0Q0</accession>
    <name>A0A1Q5U0Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0Q0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0Q0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="50"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP06049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="536" mass="58995" checksum="6257D723AE85F28A" modified="2017-04-12" version="1">MFQSVILEKEDAITQDPRGVVLTGDALRSLYALGLGKYISSIGQGKGDAVVGRDEHAEGVTVHYLNRDQKSCQIQAGWLVGADGKRGIVRKHFLEPSAGIRQEVGIFEYDGTWIAANLKITLPTPESHPDLALWAAGYDQESVFDLFWPQNWHFCRPPGRPVACGRFGPLEDRLWRHEFAVPEWDDSMDALSMFWDHLSPIITRNIEPSYGARPVEVTFPSDCIQVLRCRPFQFSHRVVNAWFANRTVLIGDAAHVFPPFGGQGVAGGVQDAVGLAWRLAILTKMGTLSSSITCRNSLLQAWAAERRMGIDNSARLTRQNGELCNKEASFKGHLQLACVKIAQAFLNGLGMRLPLVEADSRGYSGCGRGTFLAEFGGGIKLGQIYVQVRVPNLPTLRIELSDQTLRRAPTVLTLLVIQHTRCHEGQSLVDLRQLLSRSGVNSSILSDKSIVQFDPEGSSNIETGTGRWPVCRAAPTDLLAGYPLRLGYNPDQFLHRLGDSRARYGFKNQGNGTSATESEISKLLASTMAPCHFPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1N6</accession>
    <name>A0A1Q5U1N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1N6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202784" evidence="1">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="447" mass="49604" checksum="07C2B1FB48B835CC" modified="2017-04-12" version="1">MVCLLRWVLCGGFVLSLVDAIFAGRPQAIGIDFGPEMISDNVTLPACIKPELGDPFSIYLFLLRLESWSDGTLDALYGGKNEGTSGISNAVVKLFARLVSSLTCCSHDTANLSWVRQCVCSAWHGITARLRSAKRSELGEFTLNDVKDAFVDILTRLQEEARSKHNIDMQSAVIALPDFFNQTLVDLFLEASRKVGITPLVGPMSRMTVSTYSSNGTPRKADGKYLIMDLGQYYLDLQSLNASPRPMARNGRLPMDPWGSAGLDRDITRSAIERSEILQTWLSLGGSKAALQEEVRKARVLIRDNIDREVLGAKDHQDHHHNEYPLHLKDPDATAVLSWVDVEAGEMKYIQSIAQNVHNYLVAANNPTGDIRDDMIPTKIDKAFILTSGFDGSLIKQSLEHALGDVEIIGGRLRDCYLAAEGAAQVGLLYQQVWDQRQRLLWKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1W9</accession>
    <name>A0A1Q5U1W9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_6480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 7"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1W9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1W9"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000396">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000201">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000049">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="409"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="800"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="919"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="704"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1123"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP06490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130033" checksum="B861E037163A0E38" modified="2017-04-12" version="1">MAYATATSPPVMDADTQTSLKLTTSLPRSTSLHHVVTSLPSSGPTPSSAPSFTSSPTSTPVSVYPGPGTPNAFTPAGTPLQPPSEGPRGRIYPLPLPAPLELGESMMAVPETIIPNVNGVNDPSMSSSKAPGLMRRISRGAASKLTRRRQSASQNDKRDRSSGPVIMRRRSDSKNGQATTRDTALESSNEDDSIEALDGLGAWAGSEPSSLRSESRMMSARELVASAGSAVAPKVDSAVQRGTVLTKVTKKHRKQVRFFLDLDAAKVFWDVSNPAKRFYIDDIKEIRVGADARNYREEHQIPEDTESRWFTIVIADSERFKGRAFKTLHLIAPNDHILELWTTTLEHISRYRIGLMAGLAASGQSDAVLQAHWQREMSRLFPQGLRPGEEQSLDFTAVESVCRSLHINCSKNMLRAQFSKADAGRNGRLCFSEFKDFLTRLKERKDVKEIYKTRAEDHKTGLTQQEFLDFLREVQKEDVEADRAHWIALFDKFVKRSRPRLSNASDTSNTGTLPPPRMNLDTFSAYLASPNNGIYASKAPQSRFDRPLNEYFISSSHNTYLLGRQVAGASSTEAYISALQQGCRCVEIDCWDGADGRPIVSHGRTMTTSVLFADCITVINRYAFISCDFPLILSLEVHCNPEQQLAMVKIMKDTFKEQLILEPLMTNCYILPSPEELKGRILVKVKTCDETELDLRQDTVSSIGTVGTHGRKRSASSPFVRPTPPPDMTLSSSTMPLPSLSSPPSINSVDGIGPLISQDRRSLTATSMSSATEDSDGALISVHNEKKKRRRQKSKITKPLSDLGIYTRGYKWHSFSSPESRKYNHVYSFAERAFESICQNHDNKVSLEAHNRKYLTRVYPSGFRLRSSNFDPNKFWRRGVQMAALNWQTYDIGMQMNQAMFAAGTDRTGYVLKPDCLRLPMAPGEGPKRKMERRLVRFAVDVISAQQLPRPRTLGPEDSINPYVEIEMFSADDRGQSLVFGEGGMDASARSGMSGIGYPHRRRTKIEPSNGYSPVFNDRFKLSLETKYPDLVFVRWTVWSSLDGRSAGNNNSVQLATFTAKLTSLSQGYRYLPLYDGSGDQYLFSTLFCRISKEDPVPVQRLDLEELRAERMGIFRQIGQTVFKRSSSTDREKDQSADRSDPVSPEDKDSSPNLTPTVSTTSASSFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3A8</accession>
    <name>A0A1Q5U3A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3A8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="147" mass="16981" checksum="656FB226B727DAE6" modified="2017-04-12" version="1">MSIYNISKAPMGYAALIRNKSKLWRHFLILSPLHTHLSRSRYRPKKLCDFFIEAEIFSVLQSSGQRIYNRGTRRLIASHDIYPQDGVLGEILTKPAWTLPRIYSQLREKDPQLSRQALQGTFTWLKLPIVTSYVVLAYKVATKNTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3C2</accession>
    <name>A0A1Q5U3C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3C2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="112" mass="11583" checksum="4BF71EA17938B577" modified="2017-04-12" version="1">MWEFLKSPSRRRREARQRADEEFHKEQARLKALREQSPQQQAAATLKITPATPTTPAYKPYYPPSSTTSASRSRGSGYSSGGGSYGGGSGFSGDSGCSSGGDGGGGGGDGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4G6</accession>
    <name>A0A1Q5U4G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4G6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4G6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="39"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP07365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="452" mass="49126" checksum="8DA87BC30264C757" modified="2017-04-12" version="1">MSPSKNNADKVIPSEDGFADMSDREQQIYEGGIQKFNRLGWKRLTIVLIVEAVALGTLSIPATFAKLGMVAGVICCVGIGLIAVYTSYIIGQVKVKFPHISDYPEAGRQMFGRWGYEILYVMLALELLLSAGSHCLTGTIAFANITESNICSVVFGVVSAIILFIFAVPPSFSEMAILGYIDFVSIVIAVGITIIGTGVEASNSTGLAAVNWSAWPKEGLTFSEAFIALSNIIFAYSFALCQFSFMDEMHTPTDFPKSVWALGLAEIFIYTITGALVYAFVGQDVQSPALLSAGHLLSRVAFGIALPVIFISGSINTVVLGRLIHGRIFKSSNIRFVNTKMGWVTWLALIVVLTILEFVVAEVIPFFDDLLSIISSLFVSGFTFYFPAIMWFMFIREGRIFDKKNMFLTVVNTIILAIGLIVLVGGTYSSIVDIIKSYDNGTVGGVFSCKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4H3</accession>
    <name>A0A1Q5U4H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4H3"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013985140" description="Hydrophobin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="13569" checksum="B721906AB1DE1630" modified="2017-04-12" version="1">MRFSLITVLSLAGAGMVSARPSEGSMLAKRDSPDTKVQEANAALAGKKFENESEVSECIAPLLCCSSLTTPLDHIVDPILKELGVDAAKIVGSIGLLCDPYVPGTCDSAPQCCTEANLLGGTVALGCSALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U799</accession>
    <name>A0A1Q5U799_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_5665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U799"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U799"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="545"/>
            <end position="546"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP08298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="559" mass="62508" checksum="6B6E4EA39D05F7DF" modified="2017-04-12" version="1">MFQDFEIFCQLPLHYLIVGGGTAGLAVAARLSEDPEVNVGVIEAGPSALNGEDDGAITVPGRYGETIGSKYDWQFETIPQPGIGGRSLKWPRGRVLGGTSALNFMAWNRGHREDYDAWARLGNEGWGWDDLLPYFQRSETFHQPSAAHQEHYHSSYDAEFNGTDGPLHTTHIKQYGPAHQYWHATLNQLGVASSRDSLAGFNCGAWNMVCTMDPHRQERSYSASAYYAPIAERKNLHVWTDATVLNVLIEMVDGEWSATGVRVRHGDKEMEVKAVREVILCAGSIQSPQILELSGIGPRKVLEAAGIDVKIENSNVGENLQDHMMTATIFEVLPTLSSRDDILSDGILREAADRAYYASQTGPWTVLPCSVAYCPLSQVASPTEQTQLHIDAQKVAQETGRLQNELLVEQFNPTKELRGQLEYIFDLGNWSTYFQSEPGKKYGTLLQMLQYPFSRGCIHIPPRKDQSHKITVDDKPIIDPRYYLGPGNIDRQVMALGQRMAKRITKTEPLAKIIQRQVFPPPPDESTSEPSVYEDFVSNYTVTDWHRMSPLPHILLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7W4</accession>
    <name>A0A1Q5U7W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5569</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7W4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7W4"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP08582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="9303" checksum="FF00F9A4D2E40789" modified="2017-04-12" version="1">MARLSGLQRDVLSLYRQCLREVRKKPIDSQSNFKNYARAEFQKHRSVNKKDFSAIEYLLRKGQRQLEMYASPGIRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7W5</accession>
    <name>A0A1Q5U7W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7W5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7W5"/>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="660" mass="72603" checksum="4DF1353D3CA8068B" modified="2017-04-12" version="1">MGNSQSNPTKEETRRANRLSKPLTRKLAALSSPKVACAETDGPELNTGLIGWQNPWVGSNLSTDVRNSHPKAREIPPTLFETEAHPSSEKNVVESPVQSPVVQDLEILSPISPLSRTASTSRSFRRSSYQSGSYGGSSQLSFVPPQPRRANSIQTTLTRHNSVIYEDTYEDATSSNTHFLVGNQRFSLTRRRSLLTRPGVATRRTTSAVRRVPSPIGEPTDPIDDLTDCKVLQWPLPPRQRPSLDVAPPVRPTSPPDSRYTQLGALKLGSLRVVNGSASPCPSERIPLNQPGLGLDKVDAMGRIKSTLEIPAIPDLKKSDDVPGSPFSFEKSPTITVPPPTKSIFPGESEDEGIAMFDDGTSQPDKVAGDTNLDRSTVHSDSLNKSDSGYSSAASVSSYHHSRPRASFDSQTSGSCIADGHAKNIWVTSDQSRSHYRNEEIQRYFSLHEAKFKAGNYSRLHPNFDRWYDSIGPATDQPLAALRTRRSTLCAPRYTEYPAQKIELDSVVTTAAAAIHEEQVYSRGPLYADRFSLDISRSSGSSTSLGTDTPPSYQQVGAAKVQVQMHRSASERYLDAKAKHDILTHRSRSRSRPGSRVWSQKPGIEVPPLPTILSPDHLHGEEDGIGLSVPETLRGRPRSRSQDYRRRKLTKARPQGEIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA06</accession>
    <name>A0A1Q5UA06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA06"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="60856" checksum="17C24152152543C6" modified="2017-04-12" version="1">MADQAPILEKLDAAVSEVLADWNIYTTLFAGILAAFAIYSVVSNKDPDVHPFLLARQSTASPIRQAGESATYRSLETPYGFPLRSGLNVKDPGAPKWTAGRRGDLRDIWKTAVRGALNEDGTTSGKQGKIYTVLGKNAIEHSLSQVTQEINVIGRHLQKAEVKTVAVCLTDSIELLASIFAGSFYGFKIVLIPHNLPAASLSSHLQNAKADALIAEVGSVDLSLVTKANKQISNVIWVAKYGNRHMDWHEVPKDAKETLDVTVWHELAEEGKDLAGFDVPEYDPTTPAPAVNTVWPSESQYGEFIDFKQENLVAAISALGSALPRTQRFNSSDLVLSIDSLSRSYPLCQIFNALFSNASIALNSVAGENVDFALATKGISPTVIIASSRTMSEYHDRVMKPHTGLISSLGRWVQARTLDAGNMPSKNFFSQLAQVGPTAELSLEKLRLLCISHRVDADASVRMTSEQLTDLRVYMGTRIVSALTGPGIAGAISQTNVFDYRDASGPSHFGAPLSSTEVTLTGVPESQSDDYPEGQILVAGPAVVGGKTTLSARGRIGTDNTLELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA13</accession>
    <name>A0A1Q5UA13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5332</name>
        <name evidence="1" type="ORF">PENSUB_5336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000551">
        <property type="protein sequence ID" value="OKP09322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="61" mass="7138" checksum="D219B23489C160A4" modified="2017-04-12" version="1" fragment="single">MADHNEDTSWLATSELRIEDLVDLDLYDHSESSREIQAPHIRAYDELMLERRATRVGAHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAB1</accession>
    <name>A0A1Q5UAB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_5227</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAB1"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="169"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP09405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="592" mass="64765" checksum="D041828F8654F375" modified="2017-04-12" version="1">MIALDAQNNLMLENRGEPEELTLPSSESLYQAAMTMATTTVTGHGRRASMRQPELQVPNKPSTSQPTSSPIDKFPPYEDSLDAAVGSAAPSTRPHRSPSVKYAPAEAWQPRNTSFYSRDPPNGSLRNPKHRPRKSISEAITTIRNRNGSMSANAQELAEALKAPVSYRLIGLCLVWYLTSALTNTSSKSILNALPMPITLTIIQFAFVSFWCLLLVYLSTAIPWLRQSVPVLKHGIRYPSRDVISTALPLAVFQLAGHILSSMATSQIPVSLVHTIKGLSPLFTVLAYRVLFRIRYARATYLSLVPLTVGVMLACSTGISTNFFGILCALLAALVFVSQNIFSKKLFNEAERIEAEAANPARRKLDKLNLLCYCSGLAFFLTLPIWFVSEGYPLISDFIHDGAISLSQKQGSLDHGRLAIEFVFNGISHFAQNILAFVLLSMVSPVSYSVASLVKRVFVIVAAILWFGSSTTPIQAVGIGLTFVGLYLYDRNSHDDVADQRANADHFRAQEAILPMNVRHSSKPWDSNGYAFPGARSFETSTGSTSHAINSSKKQDDGPGRVRPRGASVNRTWLPGTKQESTWQPADSTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB13</accession>
    <name>A0A1Q5UB13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Extracellular endo-alpha-(1-&gt;5)-L-arabinanase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB13"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="49124" checksum="8937120A6FC6B8B3" modified="2017-04-12" version="1">MLDFFASSRSKSETPKATASASVQSLSGSQLSGSEPRSEQEQPENIESGKKKGLFSRLIARPFTRRRIIILGGLIFLILALLVLVITLPIVLTRAHKHKDPGDVYKLYPTKHEDPSYRIVENKPVYAIHNFPDPGLLNHNGTWYAYGTNPHKHDPQSIHIPVATSTDFVNWTLHEGYDAMPKLGNWEMAVNHWAPDVIERDDGKFVLYYSGQTNNFNKHHCIGAAVSNGTDPLGPFIPLNESIACPHEYGGAIDPSPFRDADGKLYVVYKGDGNSVGSGGWCGNSIKPLRPVPLILQELESDGITKVGEPGVILNINDTDGPLIEAPNIIRQDDGTYYLFFSSHCFTSLGYNVKYAHAKSVKGPYTRVDRPLLQTEDFGLKAPGGATLSHDGTKIVFHANCDGYRCMYAGGVDIRSSNHTIIMAALEIVGTISSNSTNTTTTSIADSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB76</accession>
    <name>A0A1Q5UB76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="42"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="36058" checksum="41FA4AD968000AFA" modified="2017-04-12" version="1">MPFPHEPFREPAIWMKYDHLTVKQRLDHLGGLSQFEKDIFESNVATFGSAPGSDIGFTEVLRWFALGGHSMAGVFERAGIYKLGNGGMTAFARAILRDFQGDVLFNTVVQKVDQGRNGVSLQMQDGRRIDAKAVVSTIPLNCLGDITFNPPLSALKTDAIASGHINKGAKIHFSLAATEPGWFATCSASGTSLYVFALSDHNGHEPSGPRGTWCIGFGYNGHLVDKRNSKGIIEAFRENLRPDAEVQAYLTHNWMNDPYAKGNWSCWGPNRFSRSVQELQKADGRVFFASADWADGWRGFVDGAIESGQKSANDVKEFLNSQHRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBE2</accession>
    <name>A0A1Q5UBE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000448">
        <property type="protein sequence ID" value="OKP09781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="239"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="443" mass="51309" checksum="5DC587926B2D8B62" modified="2017-04-12" version="1">MAITVYFIDKDWNYREMLLGFEPLHGPHTGSNLSDILHQLLTERGLLDRIFSVTTDNATNNETLIRALQEKLISAGAIGSRESIIRVPCMAHVIQLCLKQLLGHIKAAPKNKEVKTFWSDTQAIGLRDSVNHGDVAHTLTKFKITDVEWRQVDYLVHLTKPFFQFTMALMKTKDVTIHSVFLVYRKLLEHIERSNRKLKRKSTPWKKDMYSALLSAKQKLREYYEKTYRDHGFLYANVPIPPRLYWREHEREFPVLSRLARDLLSVPATGAGVERLFNSARDICHYRRGSLHEATIQDLMMYMCSERFTLEGEQLTRLEKPMEGESQEELEEGEALKANEEDAEPISDDEEVEESEDFERNIEPEGSHQVETILVEGDQFLMHSQTYDVEEDEEQQEEEGEEATEDETDLLPPPITQLGDRSQKRSSGRATMPSSRLRGYELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBH9</accession>
    <name>A0A1Q5UBH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4762</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBH9"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180238" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="32"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="397" mass="43436" checksum="0881729DFD5C7628" modified="2017-04-12" version="1">MFVRSILLGGAAALGASAMLVIPEMEPQVEAVEDGFMNVHPLLLEDIRHAVVDVPCRECPFREVDEEGAVSWTEGKSSSLMLDFSIEDNRLLANGRQIFPPVPPSPIRAVQQLEDGEASEPMPVGYALEVMPLGSPDDTPGTDLLDVRFTILDLETHPVPVDTVAITLIQDLAGELYIAKTEIEKTAPPPERLSWKKCNGKAKCLQELLVSRVRGLLAAAKARVLGMAGKGGRKGCHGKHHGMMGMGGHHGPPKHHDEFFSEGMPLFEEFEDFAKEHHHKGHHHHQDGNFDHPPPPHGAFAHTLSRLLRFIVIPAILGVLAGLAASAVGMLVGQAVIFLWQRYRGTKPQEHKAAWEQGDVCEKQGLMTETSEASETSEDFLPEYNDPVSRRGSLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBL0</accession>
    <name>A0A1Q5UBL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBL0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBL0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF5">
        <property type="entry name" value="PIMELOYL-[ACYL-CARRIER PROTEIN] METHYL ESTER ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="32111" checksum="8097066C102F4FA4" modified="2017-04-12" version="1">MPRYTSPVDGAQLYYRDYKPLEATGTKPALIFLHGWPYSSLAWETLTVQLCENHGFRCIAPDRRGFGKSDWDGPQSDAQITYETFAQDTVHLLEKFLDVGSFVFITSSMGAGESVLALEASDYLRKNCKGLIWVAPALPGKLPGEDNRSTGPKVVWDDICTGFQKARADFVHAALPGVIVGTSGLSVSPEVLRQHERIVEDADGLAIQRCAHIVREADFNEKLLRLGEDSQVPILCVHGDSDTGAPYEKSTKVVKEIIPRVQVELYEEAAHALNVTHAERLLGDVLKFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBY1</accession>
    <name>A0A1Q5UBY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000419">
        <property type="protein sequence ID" value="OKP09986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBY1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7613" checksum="7E745A10864CEA1E" modified="2017-04-12" version="1">MTAYPILRTEFRDKRLVRANRQSLATVSRAPAIYTSKETYLSTGGFIVEKFVITSLTQKMLPDEMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCK5</accession>
    <name>A0A1Q5UCK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyoxylate/succinic semialdehyde reductase 2, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCK5"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="58"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="216"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="341" mass="36737" checksum="E3DA352324912F4C" modified="2017-04-12" version="1">MSGFHTCFYISFPEPSTPPKTSTPITDSWQVIHIAYLPSTSTTRQLTIHWASPSDMRLGFLGLGVMGTPMARNLAKKYPVMAWNRSPAKYASFKQTDAVSFAETPVKVVQSSDIIFVMLFNAPAIQSILTTDFKRALSDKVLVNTSSVSVEFSEFLDQEIRKAGGQFVEMPVSGSKVPAEEGHLVGMMAGDPDLAKTIKPYVEPITRSAVYCGPIGSGLKTKYAINSLLIALTVGLAESMNLAKAQGLDLEAFGKVVAASPMASAYSHIKVSKMLSQDWSPQASLKDCYNSTQLIQSAAISANVKSPLMDVCGNLYAQAMESALGEEDMIAIAKQIGDREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCM5</accession>
    <name>A0A1Q5UCM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCM5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9534" checksum="FE34EF286DC16793" modified="2017-04-12" version="1">MIFIGPNDLALSILGYVPARGDEAEFVEAIEKIVAAARKHGKWVSRLSNTGALCKEHLQIFDSVALSYDVRAIQNWYTAELQVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDW0</accession>
    <name>A0A1Q5UDW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase A inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDW0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDW0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="PxpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698:SF2">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carboxyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxyltransferase" evidence="5">
        <location>
            <begin position="213"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="446" mass="47515" checksum="89AF40B848E18A06" modified="2017-04-12" version="1">MRFLPVSLTSMLVELADLEETLALLTSLQTTPVTGIEEMFPAARTLLVHFQPEEVTAAQLASELSKRELSANLLHFDRLIEIPVCHDGEDLAHVADLTGLSMKEVIQCHTKKEFTVALCGFAPGFAYLIGGDPALNVPRRENPRVQIPAGSVAIVGSFSGVYPQSSPGGWQLIGTTSMRIWDSSRSPNALLQPGNRALFPALFQDLSRCGQSSQGISTSGALDRSALKAANRIVGNPANIPCLELVPGGFSFESTARVVIGYEGAPCLVTIQDARGHTRTVTSLQPTALEPGDLMSFCHARAGVRCYMAIRGGFEVNKMLGSAATDTLAGLGHNPVIAGTCLALKDSRCNLVSVSPHETPTSSLPVAGDTVVLDVMLGPRTDCFTSKGLETFAQQSWIVTPKSTRVGIRLFGYISIERQNSNVELPSEGIVTGAIQVPPTGQPAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEK5</accession>
    <name>A0A1Q5UEK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="16076" checksum="E87ED1BF238E242C" modified="2017-04-12" version="1">MTDKENGQVASKDLGRATATDFSTTDSDANHELHFVRRGEALVEASSSQESIDGYDPDLMSGRTLLTAEEEKKLLRKIDWRLMTLCSLIFMFKNLDSNNEILQASNARIMNKGTNQNIMTQLGITSNEYNLVTVLYYVRNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEQ8</accession>
    <name>A0A1Q5UEQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEQ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="27913" checksum="CC8BCCE1C6B61C86" modified="2017-04-12" version="1">MKLYGFVTELYSYIVLCNTITPFGMNSNRTLTHDSFLQSLDDLQDFGAFGVMFSGGHGLFELISLISLFAASQESLPSINGAADPERYEIYEQLKSRIINWNPQPTEYNEYELLPGCRATLEFCRQASLLFLETAMSPFSKYDTARICHLQPLLDVAISYMPQILPSKFSCIVMWPLMIIGSCLVEEDQRMAMKDALLHNQYMMRNTAQASNLLELLWRDPDEYAIGPYGLGLLMENYKLDYGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGC1</accession>
    <name>A0A1Q5UGC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGC1"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010243187" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="23"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="264"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="769" mass="87687" checksum="BEC12EBA0C968AB3" modified="2017-04-12" version="1">MTRYLTPWRISLLCLITVYTDGLVPNSSAIDVLSFLTAGLFPLDPADKQWEKHYLPRITEIEEVLSGHESSVPGRSLWDLFLKKIWSLDSLDALEVFFNDEIPSLLTKTREQLIQDRDHGLAPENEGMRLSRSSPLGAFVRRAYLEYTRLQFHDSVTLWTGFVKYRLPTYNMWARRNASDKQDPVDINLNVHGFNSSAYLSHVVYGSIEDDEEDEGVVSVKDAERLIEFQVGELQRLGGRVPEEMRAQLKRIITSDSNAPVLMYYLEYLDAWRAGDYTSAFDNLHRYFDYTMHSNSDRSAYQFSLLNLAIIQADFECFSEAISAVQEAVAIARESHDMNCLNFCMSWLYHFGKAFPEQMREVQNSGMLGNEKEGLMFLKAKAKDAEMWSLMSTTILSEAKLEMQQGESLATIVESFVRASHINVTKGLSNPTGAYILLQSAMYARIGATHLAWLDTEVFRECYMEGHPYEEFVKLTFRNCQILAQKGNYKEAFARMNKVEPERLRAFKYNNSWTYYSGLLQLRRQINRDDKVAVEHILAQLQAIQLLDFDMRLLLAFHTIEFTLRQGDTGRALRMVEQAANTMQPENFDVHSQIKLLCLKARILEKSGHPQRGFSLAMRAASIAHRSKVLFDLWEAICTLAAVLLSLREFEATAELVESIMPQILEAEDSALTARAYSLLVDANMGIAGELSTSKQGGERTLARKEYVNRALGYIDSAYDAYEEIEDILGQTEMMAKKATVMHLTGDPVLANDYAAKYLDLRKRRGAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGL5</accession>
    <name>A0A1Q5UGL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGL5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9234" checksum="711C1C367CDF7CF0" modified="2017-04-12" version="1">MDLIVITTYEIIFSNNKTVTGESVALMQFVKESGKLALRTNKLILDPNPLMSGLAAVSEPQIPPTDQQLADKPTVNHAENVALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHX7</accession>
    <name>A0A1Q5UHX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHX7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="66"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="213" mass="23427" checksum="92B5F5AAD3092327" modified="2017-04-12" version="1">MASSTITPASLPPAGQTSNFVDPPYIGGKFVAVNCIFLPLAVIALGVRTWTRLFVVRSFRWDDLLNWGLGKHMWDVPLADFMAQFPKLNLIAAIIYCAATGFTKVSVLVFYLRIFPSRNFHIAVWTIVFIAAGYSIASILANIFSCNPIAKSWDLTITTGSCMNRPVFYFANAGLGIFTDFATVAVPIPWLRRLQMPARQKVAVGVILAMGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI36</accession>
    <name>A0A1Q5UI36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease fcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI36"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI36"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="56257" checksum="E28C7EA603F271CC" modified="2017-04-12" version="1">MAYDPEKGLAETKYPEAEQSSLDVDNDAALSHQTGMMAKCRALEARMDKRLGIESEAIVRKRPEDKKKVHWIEELSMALLWASGTMNTSCFATGFLGWEFGLSLKQSILITIFASILAATLSGFCATFGAVTGLRQISVSRYSFGWWPNKLVALLNAIQQMGWAAVSCITGGLALTAVSDGHVSLILGIVILAVVALVISFVGLKAILFYERWAWIIFFVIFMIIFGQTGKYADNAAPATATGANFAGAVLSLIAIVYGSSASWCTMASDYYVHYPADVSRVKVFLMTTFGIAIPTSIGMVAGCVVASALNSKPEWSSSYEEGLGYLIQDMLYPRGFAKFLLTLLVLSGINVNVISIYSSAISFQQLSRPFARVPRFIWTIFCFVCILALAIGGRQKLNTYLQDFLSLLGYWCTSYAVILFEEHFVFRKGNFENYDLEGWNDPARLPMGIGASVAFALGVIAWVVGMDETWFIGPLAKLIGDYGGDVANEFTFVVTALSYIPARYLELKYFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI67</accession>
    <name>A0A1Q5UI67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI67"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="391"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="536" mass="58988" checksum="F93F76794386433E" modified="2017-04-12" version="1">MAGRDLTSIINNLIALNKWSDIAMAERHYATHTLDELETEIGNEIAKVTMGDTRYKCSIFFTQDSAPVCEKICIDIGVLRDTLLPLVINSIQHTPQGNVSVTASIQADRKQLIVDVEDTGRGIHVNDQQRIFEAYEKVDPHSAGAGLGLTLASKFASLIHGSVELVSSEIGRGSHFRAIFREVECDFSSQPPQSLAVKFDSLPSRLFKFPAVSGSSSLSDYLASFLIRNGFTRSGTIENSLVILEAGHDMEEHRESLSQIPSDQVAICLVPISEEKHFLQQTEDNILYINGPFLTSTFHSALKKVHDFLKSTSKPPLHEPNALEKPIVTPITIQKNPITDESAAPVSSTIITNHISTNTTNSLTQADISVPVEIQIPSTLHPPLRTSPRPMTLIVDDNAVNLRVMETYCTKRGLPYLSAMNGRQAVEIFTKHQKQSTSSSNSNSASDEITDSSIQLIFMDLQMPVCGGIEATQQIRALEKSNNWRNAFLFVMTGQDSSADRNAAEEAGADEYFVKPVVIKQLDRVVRQYFPAFGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIB2</accession>
    <name>A0A1Q5UIB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIB2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052567">
        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="24477" checksum="F02176A486E61C69" modified="2017-04-12" version="1">MEHKTPTERANALVSALEKHGQGDYIGESINQLEHSLQAADQARKSGRRSVGIFCPYNISSLDIGARDELVIAALFHDIGQIIPLDSTKEVRMNLRGSTENVGRVGHEAIGAAYLQSLGFSETVCRLVNSHVAAKRYLTAVNRGYYDSLSSASQKSLAFQGGPFQGDELQAFEQDPLRDEMVSLRLWDDTAKLEEAETTTPRAGTYVDIITAHLSRTQLPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX5</accession>
    <name>A0A1Q5UIX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000213">
        <property type="protein sequence ID" value="OKP12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9250" checksum="EAB30DB6E635BA8C" modified="2017-04-12" version="1">MVHVNEYMEDLLHSVEVSAVFNAAEALLDMSAWSTPPEGYYHSLQNGRPFQSSEQIVAQAIIGVIQTAALAVAEADALLSRPTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ23</accession>
    <name>A0A1Q5UJ23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000209">
        <property type="protein sequence ID" value="OKP12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="437" mass="48729" checksum="4209906EF1661F4F" modified="2017-04-12" version="1">MGAAKFMPPSRQVAGIPRIVVVMARLMVDGDDRGIRPFIVALSNGKEICKGVTSVLLPELGTRTLDHCLTSFNQVRLLPNALLGDISKPEDFQAHFLSAIRRISIGTISLCLSIIPYLKNLVYIVGKYNLRRTVTGPGKIPIPIINFRSQQIPILHAIAQIRVMEAFADYAITCFMNSTSTQGRQRLATILKASFIHNMEQCSASLPQRCGAQGMFKHNQICEYNNLLHILAIAEGDNAALCTRFAIDLFLGRYNPPESTNPNSLLAQHEAGLATECMKVVESQPLEKIKHDFNRNLNPHCKPIVEAIGHRMAYDAAIAAGVNQDLVALYEVGVVKEDLSWYVEFAGLKRGRVLEMEHQALDAVLPRLNELLDELDIGAYCTAPIVSQTEWGKFMCELKGDTGNAKYELFNHTKGMKKDVLEKGKVSMKWRWLNWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJA8</accession>
    <name>A0A1Q5UJA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000199">
        <property type="protein sequence ID" value="OKP12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJA8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="416" mass="45959" checksum="7ECE5669371BA1B2" modified="2017-04-12" version="1">MASGKPSQELLDSQFLQNTPQYTSVPAKYHSSALPPFPYRLAGNGRGFRRVGNFTVNPKVPIPRAAHTEAPAKLRARQACSYCREQKAKCTGRQPCQRCEEKGVDCIYGLRSRDVLDRAWRMLGTAFQSAVAMGLHLRNSANEVQFSSKEIRYRVWWALFVMDSSLQAITGRPPKTDTHFCTTPLPMPYREEDLADNAIRHLHTDVHARNQFLGPFLFFTGVADHTTGLRPSGCTQMAGSKSRKEIADERIIQGVKNNVASATPATSVTSEASAAPKLSLFFVHAVDLAHLTHKAIGILYSPQPPQRSFSDLEVLISGFNDSMDQWLLHLPQDFNFTISHNLPSCSAQTAICVSIFLSICGKALPASCLRNAGSSAIHGRSRLALWHHPMLAGAALYHDGYYCPDGRTLVALRRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJG5</accession>
    <name>A0A1Q5UJG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJG5"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="45010" checksum="D7AB7330067945B9" modified="2017-04-12" version="1">MTIPEDILAANATGRIPDGISLSYLAESRDHSAIVGILFMVCFAGLLVLVRLYARLFLVKKLGLDDALAVLTMIVYIVFVVLSVVLINLGSGRHIEYIQYVLSMPTVRETEVLDFVAHILYTTALFLCRLSGLAFYFRISARSSKLRLGIMIVAGIITAAYLPQIFLLIFHCKPVTGLWPYEWQTEPITYKCLSWGLVYSVNSGVSLACDVMMFVIPGILIKELHVSLKKKIKLSIVMFPGVFVIVISAIRVWLVVVGQWASDGSWAYNPMLCVENAEISSTLIALSVPALKPVFGNIFSHLTEYTSSHTRSRSAGGRLRSQSKPVSGLGSSTRDDKRLLNWSKRGHDDYEMMPSEVSIARDAHNRDSTAKTPGIRVTNEVNITRMEGDRSPSQASTRASASSERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJT8</accession>
    <name>A0A1Q5UJT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-mRNA-splicing factor sap62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_1487</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJT8"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="27125" checksum="34884A9231532A47" modified="2017-04-12" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALESIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQREGKNQDPSSLPGAMGVQVKKQTIKIGRPGYKITKIRDPLTRQMGLLFQLQFQEITPGVVPRVRFMSAFEQKVEDPDKNFQYLVVAAEPYQTCSFKLQAKEIDRREGRYWNWFDEDSKEFWVQIMFKTEREERFSGVPGLAPMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJZ3</accession>
    <name>A0A1Q5UJZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJZ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJZ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7418" checksum="22B4C3ADA7DFE4DF" modified="2017-04-12" version="1">MSREAYQVPSMSGQNAFEGTSGMAVDSPAVVYICGHCASRVSLRRSEHIRCKECGHRVLYKERTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKD1</accession>
    <name>A0A1Q5UKD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKD1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="694" mass="76737" checksum="87FFA0665E4BDABE" modified="2017-04-12" version="1">MDSLNESEEGGNAPEHDRPSCQGCRRRKLKCSRQSPTCSQCERLGSPCIYDAKKGKPGIKTGAIEGLSRRIEVLEDALLREKDNTDGHLSHSPGNERLDGVVNLLSTVCIELCKLNNRNGIRTHDSSVDSVARQRHNGPSVGTPSQPSTAPDGYETYDSPHAQPRKRRRIDSCGNPKIELALPLEDLLDTTTSLPPPELLENIVTAYFINIQPWIPILHETRFRARVHDPEQRTRLIIVIHAIIVAAIRFARPEAYGLSAADLESQTRTSRSIVVLNAMDSLSVENLQALTIIAFDDIGNGNTSRAWSIVGSLTRTVEYLRLSIEDEDYDTRLLKPLLSLTPSKEWVEEEERRRVFWNIFNLDRFCSVATGWNTSLTADDVHRRLPADGGLWHREEQVTTPFFGIWDRSEARIGNSIAFLPAKYSSNPKSPKPVPDTASPHSSPQAVSHPATNSTQPDMSTVGAQISQQHTGVISVHWRYYGSEIAPEMWALVDSLDQMACRWLGVGSSSTAHGRCLASTYADHLRDLHQRCIVAPHFSVDVLGYSTVISNNHAQTITRSVSSGRTPTGQQNHQSRDDGPYNRDSAIFADFNTTDPATGANISRSEPHWGMTKENSSPRHMNNNFVQSGVGARVATGVIPDVEYSINCAPPADELSNISYLLLDQRFMDMDRVISLDDVMFSTNMAASVNGATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKH7</accession>
    <name>A0A1Q5UKH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000160">
        <property type="protein sequence ID" value="OKP12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKH7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKH7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="34787" checksum="5CA8126E8DBBF5A5" modified="2017-04-12" version="1">MYGEFPTGRYENWGKCRSLYPHVRSAMSQRPESRESLLRWATLLYRGAWYASESGNIADVREMASKSHKYRVKLLGAKDDEALASAAMLAEAYLREGRWEESEQLFVQVIEASKIKLGVDHPDTLTSMANLASTYRNQGRWEEAEQLFVQVIEASKTKLGVDHPDTLTSMANLASTYRNQGRWEEAEQLLLQVIEASKMKLSVDYPNTLTSIANLASTYRNQGRWEEAEQLFVQVIEASKIKLGVDHPDTLRSMANLASTYWNQGRWEEAEPLEVQVMETRKTKLGVDHPDTLRSITNLAATYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKN4</accession>
    <name>A0A1Q5UKN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Suppressor of disruption of TFIIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKN4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="148" mass="16924" checksum="F5195ECD9D9C47B3" modified="2017-04-12" version="1">MLSSDKFFVKHLDLTTEDAHMLHQKYYKEYGLAIEGLTRHHKIDPLEFNYEVDDALPLNEILKPDPKLRKLLESLDTTKVKPWLLTNAYVSHGKRVVKLLGVEDLFEGITYCDYGQLPLVCKPSQEMYAKAEKEAGAPSTESCYFVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL07</accession>
    <name>A0A1Q5UL07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1254</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL07"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="18972" checksum="2F5EEBB88BBDAD2F" modified="2017-04-12" version="1">MDPSSPSSRSSRDSPTINPPGSTTLSYHPSPGRQGARSESVSPRMVDTPIPDDDHGADLPMNMTASVMLTGLPRDAHQALADVEAIDAGKVTVRFQPLPSAPILKNRVFKISASQKFETVVNFLRKKLDCKATDSVFCYVNSVFAPGLDEGVGGLWRCFKTDDQLIVAYSMTPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL40</accession>
    <name>A0A1Q5UL40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL40"/>
    <dbReference type="OrthoDB" id="4220319at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="17465" checksum="2E014A7A0D479E8C" modified="2017-04-12" version="1">MWKSLISSGREAMRPISHSHPTAAIPRPVAVRRTFVSAPHLYKQSTEAQDFDRESLDPHPSEATKTGTDDQIAQHDSAFDPTNTSPESELEATERESQATGKKGTLNVSGANKAANTWRGPQEGGPARNADKEETSKRGHPSKRRTIEVKEDGTHVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL50</accession>
    <name>A0A1Q5UL50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="15">2.7.7.1</ecNumber>
            <ecNumber evidence="15">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_1316</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="15"/>
    <dbReference type="EC" id="2.7.7.18" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL50"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="16">
        <location>
            <begin position="50"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="284" mass="31836" checksum="7B849828AA6FC971" modified="2017-04-12" version="1">MTTEMVGGQSDDVHQQPAYIAPAPIGDYVFPELRLKGKMNDPEKTPLLLVACGSFSPITYLHLRMFEMAADYVKFSTDFELIGGYLSPVSDAYRKAGLASAEHRVAMCQLAVDQTSDWLMVDTWEPIQKEYQPTAVVLDHFDHEINTVRGGVEAGNGTRKPVRIALLAGADLIHTMSTPGVWSQQDLDHILGKYGSFIVERSGTDIDEALASLQPWKENIHVIQQLIQNDVSSTKIRLFLRREMSVRYLIPVPVIHYIEQHHLYEDDGTSNEKGKERHETGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULM6</accession>
    <name>A0A1Q5ULM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCA tRNA nucleotidyltransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULM6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="48"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="228"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="528" mass="59846" checksum="0CEE0A526EBDFA75" modified="2017-04-12" version="1">MDLSNPTIHLTPLESTLRTLLLDVATYIQQEGITEEGSNVKKHPETVLRFTGGWVRDKLLGVDSHDIDVGISSMTGYQFGMALKDYLDVPENLEKYKKSLPSEEMSDAIVSLHKIDANPEKSKHLETVTTKIFGLDIDLVNLRKETYSEDSRNPQMEFGTAEEDALRRDATINALFYNLNESKLEDLTKRGLDDMKKHIIRTPLEPYQTFKDDPLRVLRLIRFASRLGYQIDPETESAMQNEDISVALKLKISKERVLAELEKMLHGPDPHGALQFIDRLGLYPTIFANHQDKVTADTSTWPLAYNALARLLQPESNEAALERVRNILLRDKSCHYNAWMIAAFAPWTSVPARGTSTEKRPPPTRPVEVGRDSLKADNKTLFILRDATLHFRDIIECKNSLLGNTIQATPAEIRQQIGLRIRSWGKEWRLCVVLAILQEVMGGRDLTDVAQEYDQFLAYVVEKDLDNVCELKPIVNGGEIMQHLGAKKGPWMSRATSLVLEWQLLHPEITDKSVVLEEISARRAELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULT7</accession>
    <name>A0A1Q5ULT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tuberous sclerosis 2 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5ULT7"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1520"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1578" mass="174867" checksum="7B35DAA427D76DEC" modified="2017-04-12" version="1">MSPDDAPPAPHHKPSSSSFADVFKTLGVGRPKSHSPVSLQDSSSDSQSHTTDSRGTTNRLILGLEAMHRGSVVSSSSDAPHGPDFESSLRILSQKQNLNHAIEEADLVSRTLSWFTPEQSVALWEAAEPLLHHESSSDAQKVGAKLLETIASRQDLSPTARRMIFESIASPTESEVIAARVQSLIALSDHGRKLDFTNTSILHIISSWIVPLYMTIATTRSKLKKGKALKPNELVQDEAILGDLFQFAVDLITLQRKSPTSEEIEMLLTETFTICKKTSVATDIKNSLAVFDAVIMYSSVPDASFVPLLEVLCSIHASVKALSGPTSRAVRSLAKSPKQEEMVTTLHDFLRESCAEDSPRNLNVHRGALYIFSDLARAYGQGGMPEISFDQLVDSLTVIAQKDDGRVDADILDLCLNMLESDYSRVSLAYGWTQFIDLLLLCSRRIYEDYDDPIGSPTSPQQSHLKNAHDDVKSHILANIIRITSVLESLWDQLTKEQKQQSVRFLAKNHQHIDHSQSELIINMMREDTLCHPSEGSNWVQHCREIIERFIQPRKQSSDIRILALDTLKEALAGNEHLLFSEEYGLLDLLLADFSAEHDLLFLESLVSFITDPAIHSNDDEGFKRLIDTIARPMERDPSKDEPRETSPSYAPRRTSTSVLELSMGNVCAVGLVKMMIRALNASAAKSIVIFEALLQIAQSPDRPADARLTVLKLLFRLRCDSLGAITVVSTSENDFLMNVLGRNVDVTSMLHPSSESPIRDLPQQDNLIPSMGPKIPAKELPAGFLSKSSPRGSISARGSKLTPPVWTYSQPQVLPEQPSEKSSPFVFAHTQKNGASSPADSTPTLMGVLKVNMWVECVISLLQRETDWDVYSYVLTHLGPQLSNKEFFSNTIPQIKLLRSILCDQVKNESFHEPPALTGLKKSDVAACIFDTLCMLVSYHEHFAKSEEDDLVRAFMLGIIGSWGATSRGCIQALSLCCHEIPMSVTKSLTNILDKMSKVITMSNIAVHILEFLALLARLPDVYVNLREEEIRTVFGICIRFLQTSREQEQRQKASESPTARASQQPQSRHSGGAREIAAGPTEATEAPAHDAMSKYIMTLTYSVMVFWYLSLKLQDRPKHVNWITSRLIFHDEHGKEVVEEQSQVFIDLMQRVAFSDLGETIPYETFPPTPEDGPVSKKSWVVGMSIVTVETAGISGLTQLAKRQASGTTYSMYQQRTAPVLPHQAPATPDAHLHSDATRTAVLPSHIMLQLTATAFPTPTVMQPIPVPEDDITRRAITNFDRTDIVDGHRIGVVYLDNGQSKEAEILANTGGSPDYEHFLSGLGTKVSLRNAQFNTQGLYADTDGEATYAWRDRVTEIVYHVATMMPTNFDHDPNCINKKRNLGNNFVTIVFNRSNLPFNFDTIPSEFNSINIVITPCSRIAYDESGASIGETDPDKQYYTVRVMSKPGYPDVSPAATPKVISGKNLAPFVRILALNASVFSLVWNNKGGEHASSWRTRLREIKKVRERALAAQAQSAAEAAEGAYPGQRRNTKPNIFSEELPTRTAPVQTDFAAEWNAASGTNICQNLDFSRWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM10</accession>
    <name>A0A1Q5UM10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM10"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM10"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="525" mass="59704" checksum="B59AEEED25809305" modified="2017-04-12" version="1">MAPRKGSNASVTREKKDRVLPGGRVSGPKANAYANSRIAKSTRSPSKPKRPPGRPFKMPARSHSSQPSSRPTSAVQTSATPSMASTPAPRALSILETLPVEVIEQIFLYSLNLNLPRASPVLAAAVSRDQIYRILIILAFWDDPPTNPRSEPINSILRPLDYAPLTLDQRGTLQEAVFRCRWCTMERVREQIPTIMILTIHRQWFNLGIKMEPDQKAALDKFMNREDDMIRVFRGEGPPVKLAAQLCQHPEMLRVSRIPGPHKYELHVKPMVMVEVRSETMKSIVAWPALSILNFPDHLLRGHKTGFTPDDVMYLEMLRMCSDNYAQNDTPLLPSTISTVNRTVLHEGVGKAIRTQNYNALISLLKLDEYIFRFHISRQGRPVCYTIPSDHFLTVTRVGRDKPHLNAAFFEALIRASAESIPTNAPEIVQWTLENVHLLQRNPSTYNEINGKLAHWLSNFVLRLPEQLDYTQGFPQGQLFNCGQLDPLDLEACRFIEEVLEPCRGPPTNWMPESQFRIEEWWVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM53</accession>
    <name>A0A1Q5UM53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM53"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="21645" checksum="6929F750C2112996" modified="2017-04-12" version="1">MPIIHDSAHGAADTGIEEEREENESIGLSRTRERRRLEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEGNKEGPTRPQAQRKGEVLAIPGHHLARAKKTTNPTNPLRSKGIDVKGDQIINTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM90</accession>
    <name>A0A1Q5UM90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM90"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="16006" checksum="0393608F9E7AE7D7" modified="2017-04-12" version="1">MTKPRCRLPQAPDMRLMQDSEVDMEKEDMTTRAVELEEDMKIQHTVTRLALQEPRHMGRRNNHAQCAHLLDRAHQMLDVLRRDMMTVEDILESAHRDQAGRDLRVVGPLQVTLTVPFPLFLAGETLETDAVLRHEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM91</accession>
    <name>A0A1Q5UM91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Meiotic recombination protein rec8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="4">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="590" mass="64104" checksum="38BF3F0B698980C4" modified="2017-04-12" version="1">MALRLQGSLLYGVSRVYDQQCGYTLLDAQMMRDKMVTMLKQLPGGGLDPSAGKTKPTSLILPYDPTFLPETGLPGLDLNFALFDVMSDDSSTQRSGSLTSSPATSQSANSQIGVIQLELPTYDLIREGDVQDLNLADTLTSGKKREFLGKDLNDEGVLLQPDFEFDEDGNIIEFDASHLSPSKRRKVSPEHGVLEGPAGEDVQEGAVDEVPLPMMDDGMEINAQPGPQDPENNNALSPKDRLMEDGEIERTGEVRAQQRIRQVKNIISDDSTTLRNTDLAKWNDEYSANMAHATKLKKQNKLPTLAKKNAAFWVFGLGIGSVGMGLGQRREDGPLKEYSGDALYSLVPGEKHSHRVEPDENDEQQSHGALGHSGQKQTLDVEIGRQAPSSVYDDRSSQMPWNITASLQGSVRGQRFGSISGSSARPRGRLISASPLAGRDRHSSLSIPNVGDDLGELEQLDITQYLEGELAPDNEDISTLTARRKSMIDRITSSLDTESLNFFEFIQMKLDESASTKPGVITFPELLPPTETTRIVAAHGFMNVLTLATKGVLDVSQESCTDLGAGTWGIRFQHGDISLRMTGAGAGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMF8</accession>
    <name>A0A1Q5UMF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMF8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="9020" checksum="EE2579731C0AFE9D" modified="2017-04-12" version="1">MIDVTLEATLLKSSVFVKVRLEMALDSRSICLCTWWLAEGAEQCRDTNHETRTESTKQLITAMEVMAMKAVQPSQQSITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNT4</accession>
    <name>A0A1Q5UNT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNT4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="21432" checksum="2B442FF58CCFC6A0" modified="2017-04-12" version="1">MKVTLESYNPEWPLKFREVHAQLSSILKDVPIISIEHVGSTSIPTMKAKPVLDIDIITPASALEAASKALSDAGYTDCGEMGIPGRFVFRQPGYGILDVAYGMGVQGELRRNTYVVIEGCTALRNHLDVRRVLLEDQELREEYARVKSNMEGMEFEKMDQYVFGKTQVLCKILQKAGWSEEELQSVMEVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNV5</accession>
    <name>A0A1Q5UNV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_161</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNV5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP14167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="496" mass="54318" checksum="719B6CC08A4DBC63" modified="2017-04-12" version="1">MISRAAAPSTSTLVSLSSRSLRAQGAAARSFATVQEAPPVRHYGGLRDQDRIFTNLYGHHSPDLKSSMKYGGDWHRTKDIVLKGDDWLISEIKASGLRGRGGAGFPSGLKYSFMNTKDWDKDPRPRYLVINADEGEPGTCKDREIMRKDPHKLIEGCLVVGRAMNANAAYIYIRGEFYQEATVLQQAINEAYAAGYIGKNACGTGYDFDVYIHRGMGAYVCGEETSLIESIEGKAGKPRLKPPFPAAVGLFGCPSTVTNVETVAVVPTIVRRGASWFSSFGRERNAGTKLFCISGHVNNPATVEEEMSIPLRDLIEKHCGGVRGGWDNLLAVIPGGSSTPVIPKSVADNQLMDFDALKDSQSGLGTAAVIVMDKSTDIIRAISRLSTFYKHESCGQCTPCREGSKWTMQMMQRMETGNAREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARIRQYEKEIGGAPFAGGWKPEARAEGKLISPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ21</accession>
    <name>A0A1Q5UQ21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ21"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ21"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="168" mass="19243" checksum="6F931796311857A1" modified="2017-04-12" version="1">MENIELTPQTPSYSNNTWELEGQSNEHIVAVAVFAYEVANIIQPGIEFRQHTNLKNSYYQYYEEVFPTIDDGWRDLYPSRVGKSYEKEFKAMASILGFAPRDLSARFDSGMSFQTTGSVATPQGRLVTFPNVLEHRLEPFELSDPTRPGHYRYIKLYLVDPQCTTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ32</accession>
    <name>A0A1Q5UQ32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein sti1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ32"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ32"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="517"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="569" mass="62526" checksum="4C930001C2DDC792" modified="2017-04-12" version="1">MADALKAEGNKAFSAKDYPTAIEKFTQAIAIEPENHILYSNRSAVYSAQAEYQKALEDAEKAISIKPDWSKGQLRKGAAYRGLGDLLAAHDAYEEALNLEPGNEQAKSGLSAVQRAINAEATADGVEGDPSAGLGGMFNDPALFQKLANNPKTASLLGDAEFMAKLKKIQQNPNSVGEEIRDPRFLQVMSVLLGIDMSFGAPEGGPAGAQAEPTPETKPAPPQPKKEPTPEPEDEEAIAKKKAQEAGDAEKKIGNDYYKKKELDKAIEHYEKAWELNKDITYLNNIGAAKFEKGDYQGTIETCQKAVEEGRDLRAPFQTIAKAFTRIGSAYEKLGDLTQAIDYYNKSLMEHRTPEALTKLRAAEKTKLTAEKDAYVDAGLAEKARELGQQKFQAADWPGAVDAFTEMTKRAPTDPRGYSNRAAALIKLMAFPQAVQDCDEAIARDSKFIRAYMRKGQALVAMKEYNRAIDTFTEAAEQDDGTHAREIEQQQQKCLEAQFSARAGETEQQTMERIQNDPEIMAILNDPVMQSILNQAKSDPAALQEHMKNASVRIKIQKLMAAGVIRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQM4</accession>
    <name>A0A1Q5UQM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_5842</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.150"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UQM4"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="500"/>
            <end position="559"/>
        </location>
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        <location>
            <begin position="2140"/>
            <end position="2471"/>
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            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="57"/>
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            <begin position="28"/>
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            <begin position="394"/>
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            <begin position="646"/>
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            <dbReference type="ARBA" id="ARBA00000768"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00075294"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51455"/>
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        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
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    <sequence length="2514" mass="278735" checksum="0560463E49BB90ED" modified="2017-04-12" version="1">MEQKSHETPSPSASSGFLPLGRRGSRGSLATTQTDRENINTALDQIHNTAYQSDSLTLFNEFTSPPAPAPASDDKGLSEELQGGLSGLYSRFRTSVGGMRDIVSGGAKITDKNAVDSSTVKTPSSERSMTKSISDLTVSSADNLPSYPNSSQGSRLHSPVVPNFHPSQDPTPQSTAGKISKLSSKSVSIASKASVSAAPAGKASLAPLTKSTGNSVVADPSITPINVGAIGQPRHSRSSSVNVPAQAFQNAESSSIGSRDAPTDMSASQTSSVLNPGFSHSPVLSTKTHGSLYEEPNSLEASGSIIPANHAMGSSSRKSSNAGQSRVPDDMSQSNATRTSKPSELTQDSRIQIPESGSNSRLSIGGREDSTTPSVLSNSLSKMASQAGGSYAVDSASDSTAATPRDGASVGGPANSSIPTSPTAGKSHPQATKNRLPGYVMSRASTAETTTTVSSLPPLNTAVPRITTQGPGRNRPQAAGDGVLSQLRSRLLSRDFWMRDENAKDCFHCGEPFTTFRRKHHCRTCGQIFDSKCTLLVPGTRFGQPGTIRVCKPCEQMINAHDDDSSEYSDSEQSPIIVNPRVSDLGWGGSSARPSGEDDDATSIRSQSIDQVLRTPTMAIPATRRAGEGHNRGSAVLEINSDRPLTRPTSSRSLRSSLGVRPHSISHKRHHSRQQYIRGFKPFHDDRAPFQRRHPEDLTAESRLPAFHKDNIIDPDLAQYLSDDASSGDEQPSLLSAVSEGNLSKSGGDTERAAGLGGFLAAMKKGRSAFGDRSAPSVNNQSARDADDASITSSRAVNLPRSSRRRNLSVASSVHVRHSPRTSKESIFLQDPTFPVVPFVTSLKQSGFKMTRSSSMRGTGAPPVELNKASREHVQKLLRQLLVEASLPNSENWEKALMPILLKAADEVDPDVQRGDDMDIRHYIKLKKIPGGRPGDTSYVSGLVFSKNLALKSMPRSIPRPNILIITFPLEYARQQQQFMSLEPVIRQEREFLENLVSRIAALHPNLLLVETNVSGLALALLEQAGIATAYNVKPSVLEAVSRCTQTRIVTSMDKLLTATLHSDCSSFDVKTYVHGGRRKTYMYISGCPKELGCTIVLRGGDEGILGKVKQITEFMVYVVYNLRLETYLMRDEFAKLPTTSENVAVQIVCSDEKKAHSQLVVYQTNAGATESNSVNEKPAEDSEHPLPMSTEITEVPDDVPMPTYHNDMVHDHQTKILSASPFVKFEPPYLLMRTREMERRLAYLKRLRDQVEYTEETSEEKTKPQKFILITPEMVHASPHDAPPKVKEVLRAAHDAEYDRALYHYQTQKRQWEAYVSGNSNMFDPYAHQNIVVLFSLVCTTTSVPCSGPDIFALEFYNEHGDDTIFEPDCTIGQYVEDLCHTANAVCNVNGCEKRMSEHHRQYVHGDAQISVLVQPYPSKLRGMQDTVLMWSTCKICGNETQVTLMSENTWKYSFGKYLEVSFWGRNMHARAGVCPHDLQRDHLRYFGFKDVAIRIQYDTIHLLEIVVPRPRVTWKVDNDLKLRNSIYSDTSERLNKFMKSIHVRLKGINVESVLPELLDECKKQIESLIKKAQEDHAALNKRLQDRYTSSRYWEVIPLNEVLRAIQEKVVEWDTIFADFEKNFFPSEKDIKILATLQLKKIFLDKDATSMTTEDGLQTPTGMEDDTTPTDEKPRMMRRMTLSPEKAQNVLVSVVEEHTGRTQRDAPPESTELTPMPTPTNESALSVDAVDGRKSSPQDEAVLQEEVRHLDLAVPAGQSERSPPDSSTPLDKPLSKVDGSTALAEHEPPHSIRDVSTPSPPDACEPVPGTKGKANEENPATPISSTPPNRPSAIPRLAEVAFRRSGKTRSPPLIRAQSQPAHLVREKSFGLKLSHTNSNESGTSRGDSTKSSEKKFTERLGLTALKNGRFAPGHSLIPRSTPKRGTTRVSNLARHFEQLSREFEKERQRERRQRAARNTYSRAFPLASSKPIVEVYRNVKEAVEEREPHVDGDDSLPAARRRPSEDAGRKSDDSMNHREPEEPVPKSPVQVTPSESFGPGDLVRSDSQLMSDAEGDDGRSDEERNTAEDLHHVDSQDDAKTLPDDDSIDFKDLPKHERTTLLKMLTNFWSERSASGWTALDYPLSAGDHVFSDCDIIVREDEPSSLIAFALDSSDYKDKLASIQERYDREDQPPEFEQDTVAANEARLEHALLRQTGTHLKYQFQEGQAKMLCKVFYAEQFEALRKKCGVADRIVESLSRCLKWDSKGGKTKSIFLKTLDDRFVLKSLAPVETQAFLKFAPAYFQIMSEALFHDLPSAIAKMFGFYQIIIKNPVTGIEQNWFLLLMENLFYDRAPNRLFDLKGSMRNRKVESTGEQDEVLLDENMVDFIYETPLFAREHSKKLLSQSVWNDTLFLGRQNVMDYSLMIAIDEKRSELVVGIIDCIRTYTWDKKLESWIKDRGFAGGGRNRPTVTSPREYKSRFREAMARYVLQAPSCWHQFQPSAMYRYPQGEHHITNATDLDVIDGPEAGAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQT3</accession>
    <name>A0A1Q5UQT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQT3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQT3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="57" mass="6255" checksum="8061348D0AFC4F8D" modified="2017-04-12" version="1">MGLMGVGKGDADADIEVDGALATWELRLQGQSYYDHEVGQIGNDLWRKGIDCWISTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URE2</accession>
    <name>A0A1Q5URE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase CCNB1IP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="30948" checksum="21B367D62B44A933" modified="2017-04-12" version="1">MQGAIEGEGRGNDFHIFCLGCADGLGLSLPTADDRRCPACQTVLSNPDDAVSTILNPTEDYKTSVLSGLDPNTIMECAGRALGFWAYQSTQEIFYQEFLGKSLTDKYASLSTQMDKVIHNANSEISTLHSKVSDLQAAQEQLQKKNQELVDLYRDKSKKLTQMRNLYNLLKARAMKSRMETAASENVSQTLNTISPRTGPAMPPAQPGTSMPNIQKARTPKTHSFPFSPEGVEQLHRYQRSGTGSSKMSRPQMGGKSAMPPPGGHAVFNIRTVSGKTILYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URH3</accession>
    <name>A0A1Q5URH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pheromone-regulated membrane protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URH3"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="850"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="445"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="723"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="885" mass="97087" checksum="2B45B21501A392DF" modified="2017-04-12" version="1">MSDPIHAPHPSPNEEYAEFPLPSIDTLSPINPSSRQSLERETTADAHQYEAGLADPTPQPETVPLTEPLVNVEPEQSRIRSPRVRFRSISRSISERYHHLHDGSHRVFSDQSDAAHRPLLPPPADWTDVPLSGTVTPPAPTHSRHKGLAGGRTPHHDYAPVDPEKRDHHDPNTERAHPARDRFRAAGQLLRQKTVRLTERLGRPPDEGEALSASMLPDDLDIPMEELQARRARHDADRLRMLEAGEEPHQPPPSAEAHRLVRSMTQGQDNLALRKRRPRGAYQRSGQTTPEGMLKDFARRRSSGGFAGGSGILSQLLKLHASQTASSSRPESVITDDSDSDTQVSSGATTPKKIGSLSPSMPPSMPTSGSATPRKEKIKWYKKSAHRSTSSLIDASMNLSRASLPPGAADSLYPGKRHRKSKRRTRLEDEIRVTVHIAEILARQRYIMQLCRALMRYGAPTHRLEEYMQMTARVLEVSGQFLYLPGCMIMSFDDPTTRTAEVKLVRMVQGVDLGRLADTHNVYKNVVHDLIGVEEATQELDEIMSRKPRFNKWILVLMYGLASATVGPFAFSARPIDMPVIFCLGCLVGLMQHVLAPRSVLYSNVFEVTAAVLTSFLARALGSIKITRNGQTEELFCFSALAQSSIALILPGFMVLCSSLELQSHQMIAGSIRMVYAIIYSLFLGYGITVGTTIYGLIDRNATSATTCSNLDVYGSAYARQFPFVAVYAIFLAIVNHGKWKQMPVMVFIAVSGYITNYFSTTKLGTQSEVANTVGAFTIGVLGNLYSRLWHGHAATAILPGIFVLVPSGLASSGSLIAGVQYADQVRYNLETSGNSTSTSSLSDTSVASLGFGMIQVAIGITVGLFIAALVVYPFGKKRTGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URU5</accession>
    <name>A0A1Q5URU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URU5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="9272" checksum="086FC74786C993EE" modified="2017-04-12" version="1">MGGLTTPAIIVIVLVGCLAITALGAALFRHYRPLEEEARYSASYEQGQYMRTVRMRNYGHLKQESLGPARDLESRCTSSLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SML7</accession>
    <name>A0A1Q5SML7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphosulfolactate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SML7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SML7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27370" checksum="4061947FA6EDAFC6" modified="2017-04-12" version="1">MTSITLLITTASKQITHRTVPHIAKGSFTLFQEKTLRELIDLAHDNGVYVSTGGWAERLLTHPDPNTVFDRYLRKCKDLGFDIIELSSGFLSIPEDDWLRLVDKVQSYKLEPKPELGIQFGAGGDTPTSGLEAIGTSDPGKLINLGRKFLDAGFKRLMIESDGITENVNSWRTDGVSRIMKELPPERVIFEAADPKVFNWYIREFGVDVDLFVDHSQIAQLTCLRSGIWGTADTWGKIVTFRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMM3</accession>
    <name>A0A1Q5SMM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat protein oca3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="769"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="603"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="867"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="934" mass="100598" checksum="0A162CA9833097C8" modified="2017-04-12" version="1">MGGLADAEVNGSDVLSALRLSQQAPAILGHGPAPNTHAASSKSSRDTAEEYSRIEQLFLACLQTGDDQSAQTCLDRLSNRFGPSNERVMGLRGLFQEATAKDQPALEKCLAEYETILSESPVNVPIMKRRVALLRSLQRPSDAIAALIQLLDAIPTDAEAWGELADLYQSQGLGSQAIFSLEEALLIAPNSWNIHARLGELLYVCSSSSEGDAARLAGKSVQHFCRSIELCDDYLRGFYGLALASSRVLDNKYAPESPSDPAVPSRKTIQQLQAFALQRLEHIIQSRSVDDQHWASSRSELIAAKELLNRFAPLSISIDPQDPHGSDSLSDEDDSSPVHIGSHDFDEDYDEWAQLSYPDELKPSDSASRPRISHRSRSLHGSRSASGRPTPAHRRMVPERESRESYGTRSRRHPSPPESPDSGDSEEYPIPSHYTRAPPAERRWPQAPAAPGYPPSNSSGPTFGAYPPGQAPPYQQHPNGELVRLGPANPGAQPYGPGHYPYGAHGAQFQAPHAAAMHQFYPHDQGHPRHPSRPPPQSRMDPHNPQPHMPPHMAGHVSPSPYGASPFHQELMHYAPNPFLNYRDPYSMIPGMVPPGFFPYPQVPSPSQLPEAAKSPAPAPAPTPAPAPAPEPASAPAPAADAAKDEAIARLEKLIMDERAEREAKEAARIAAIEREKAEKAAREQQLAHDRKIAEEAAFLARTDAEKRAAEAAAAAKDEAEKLAATAASEAAAAATKAATDAAAAAAEQAAKEAASAAAAAANKPPPEKKKPIKFKDAVGRKFSFPFELCATWQGMEDLIKQAFLHIEVIGPHVAEGHYDLVGPNGDIILPQVWETVVEPDWTITMHMWPIPEKPKDPEPPAKEEGAAPPAKADPPSAAAAPEPKKKPEVVKKPVRKGDAGGFAKWMLGGRPPPKGPKAAKAAEKKPEPAPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMM5</accession>
    <name>A0A1Q5SMM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMM5"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="5">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO89193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="236" mass="26320" checksum="DBECFD678998C87D" modified="2017-04-12" version="1">MALHNPQVRSLPRLFQTLNISKQCIRPLHRKAAPSVPAPTPFVPDVQTFLTLIGREMSKHASKISSWEQLFASNSDQLRELGIEPARQRRYLMRKREKFRNGVYGPGGDLEQVVDGVAQLRVVEVPRESGSAADGASSATLTPGMKKAIVNLAPDVTEYKHSVTAELKKFAHMKIHRGSKIMGPFLQPIKGSHGSAATISVQEGMWEDKRGVKVDGGERRRVEVRAKKRLEERRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SND9</accession>
    <name>A0A1Q5SND9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SND9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SND9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="719"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO89518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="941" mass="105453" checksum="D057CB450514BB1B" modified="2017-04-12" version="1">MAEPTTEVGETKHEVDPSSDNINGAQQAPDVSVKDAATTTASAENAPKVAAVCKKHPDPKNDGHKKKKKRKSKKKKQHHEAAESSSSESSSSSSSSSSDSDSAANSASDSEEADSDSADTESDAGHRKRQRLRAKARAKRAQRDKKKNKKKRKTKSRKAAQPDSESESSSDSDSKSSESDDEGDSAVDEKALRKLVARLKLQQKRGKRLRDQANDSLGGLDPLGDGRRDKKSRKKKPASKVAFKRVDQLWDSTIHNYKLTETVDDPDADGWDQYIFTVRRKFNWENKYLETVVDIKSKHLRDALGKVMDGVKGVSLVQEPAVVDPNMLFLYLEETRQYMKELKRQSRNEKKKKARKIAAAKAAHLKVLIKYLDTDYADIKKTLYPLLEANTITFDLLWALFKPNTIAYTPTYGNSDEPRAFKIEYAMKESSFMRGQWYSVEGRYLEYDGKDFGFGTMSADVDAFKGARKITSLACYPLQYHRDAEALRARLVERGKRFVSLRGMNYRFHKGMAFYKKKRSFVIKVNINGRVMIDPAIHRRINPNYPISTVRPKDPDLLDGSEAGLSDLEDDGSDGCCCGGSESDSDRGCSSDTPRTVYKVIEDEDGIPRVVEVEVDENGNEIHKEKMDRIEGDAAGNKEREFTEEELLVASPVVLGFAFSEKLWLEFTISGISDIEWDADAFDSLVLASNQKSIVKALVESHTFHAAENIDDVIQGKGKGLVAVLHGPPGTGKTLTAEGIAELLRRPLYMVSAGELGTDSRTLEAELNKILDIAHSWGAVLLLDEADIFLEKRTIHDIHRNALVSIFLRLLEYFQGILFLTTNRVETFDDAFQSRIHVALRYGDLNAKAKRSIWKMFLERVRAIEGVKTATFTETDYDLLSRHTLNGRQIKNSVRTAQALAVNERSPLSMEHIKRVLEVAETFDQDLRGGTGYLDAMRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNP0</accession>
    <name>A0A1Q5SNP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="301" mass="32954" checksum="4A693BE3BDB95DB8" modified="2017-04-12" version="1">MTTKPGILPREGLYIDPIFNYLRQTLLHPLFTLGCLYLVHGAKLSAVVPYEKSVQLIAGTSFFLWLNDWLSAKSRNNWVIDDSWDWKKELVVVTGGSGGIGGGVAQRLAAMGARVIVLDITPLTYKPVVVNNAGLSRGQTIVEGNYSDNIITLKTNLLAPFLLSKEFLPNMIRQNHGHIFNVASMSAYIPPPGIADYAASKAGLIAFNECLSQELRVQNALKVRTSLAVLSFTKTPLFKGETNQSRFLMPLLHVDTVVDAIVDTLDGLATGPFDKQLVCLNLMEYELASPGSDVFTTTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP13</accession>
    <name>A0A1Q5SP13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SP13"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="20268" checksum="D64F14EA3C959580" modified="2017-04-12" version="1">MRSSPNVIITGTPGVGKTVHCEQLAQDTGLKHLSVNQIAKERDCFEEFDEERKSWVVDEDKLLDAIEDEVLQGGYLIDWHACDLFPKSWIDLVVVIRCPETSILYDRLSSRGYHEEKLQENLDAEIFGVLSEEAREAFDEEIVVELNSEKDGDVDSNCARISEWVENWKKQHAEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQ18</accession>
    <name>A0A1Q5SQ18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000762">
        <property type="protein sequence ID" value="OKO90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQ18"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="391" mass="44268" checksum="DA5B3FF47E4D0957" modified="2017-04-12" version="1">MQPNNPPNNVVGELDPNKTLQVEPAHHQNQSGCGKTVFFGVSSSYVPDWDTRAAFRELYQNWRDAILARSNLGRLDFQPFYEDRGDCVAIIVPDLSDRHRQGRALGFIKYDKHSGCVTISNSCAELGLNALELGSSSKQHDSNSAGCHGEGLKLAALVMVRSGFEVELSASRRYWHFGLLESRLFCDIKPSNQPSPESSDPRGDMFRLRSRVERDVTVEIRAPKESRKNAVSLAEFRTWLTVTLDIRGFSHPSDVLETEVGDLILDPDFHSRVYLKGMRLPCSGSGLKQYRFAYNFLQGKVNRDRQILVDRDEEANMVRRIWEAAIWKHRTAFLPIYVGLLRNSPEALDVESATHFLQSSTKLLIWKHLRGEAGDDKFFYNEASSAEVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRP4</accession>
    <name>A0A1Q5SRP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRP4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10171" checksum="7EEFC772681FAD38" modified="2017-04-12" version="1">MASILLAARCSNPPLTVGKNWPSKFVQQRDELRSRFSRWYDYHRALNVDPNTRTPEHPNTLRAWFTTVQSVINENGIQAEDIYNFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSF6</accession>
    <name>A0A1Q5SSF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSF6"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO90924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="507" mass="55165" checksum="6C61E84C8AFE36FF" modified="2017-04-12" version="1">MNFDNIELAVTKSVDQDALDLVALGHDQVFSRKFSLWSMLALAFCVLGSWGAISSDLAIGFSSGGPVIILWGLVLVALCNLCVVLSLGELCSSMPTALGQAYYVFRLCGSPTGRFLSYMCAWINVFGWWTATATLVAFNTDFLLGMKLMFDSEWDGINQGWISFVIYLGLSLLVTVVNVVGCRKDPILPWLNNVMGVGFAALFVVFSLAFLISVATNTHLSFQNPTFVFGTWTNQTGWNDAVTWFLGLLQSAYGLTAFDSVIHMAEEIPDPRRNVPKAMYLSILSGAGTSFVFMVICLFCLQDETTIADHPSGLPFIGLAQQILGLQGAAALVALFTIISIGQNVSVATTASRMTWGFARDGGIPWSRYFSHVDPGWKAPVRAIWAQGIITALIGVLYLFSTTVLQAIVSVSSIALMISYGMPIATLLIVGRDKLNPGPFRLGKWGTTLNTVSVITCTVIAVFFFFPGTPKPSGSDMNYAIGVFGAMMLVSQLFWLIKGRHSYFRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUE4</accession>
    <name>A0A1Q5SUE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="156" mass="16709" checksum="020A298DE4E5577C" modified="2017-04-12" version="1">MKNVAGWFSFEALRRDWDGGWVWVWVSSEEEEGWVGAEFGSGSASTKKGDMKAFPESKGVEKESSARATPSASRSADSASDDGVQTVVSGTGKRRQPTVKRGSSRVSRGLAYFMLGAAAAGAAYWRWAAHEGCWALLGVNWASHGRGGTAMTVERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV71</accession>
    <name>A0A1Q5SV71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV71"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SV71"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="224" mass="25534" checksum="319F4F8D1F60C7F0" modified="2017-04-12" version="1">MTFEILPLEPADIPECFAAAQKAFVEFSRLIFKPDHLSTESAELLIKSRIQGFNNRNLQSRNFKAVDCETGTIIAAARWRVYPEDELLIKSVDEIVEAKLQPRVPELREDVARAFYTMLNQGKREIAGIEKDKDGRTVKLMRRVELESLFTHPSYQRRGAARALLQRCIQEADLLGLVVYLEATQDGKPLYENCGFEAIRTHTFEAEKFGGEGAHQYTIHDMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW91</accession>
    <name>A0A1Q5SW91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW91"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="113"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="622" mass="69904" checksum="628ED778EACD6C8F" modified="2017-04-12" version="1">MGSPDGAPDEKPDAPKGDEDYETLKYQLLGPSLTKAGQDAVDQQKVSEIIYNASKGSKFFDHEQERDRNLTVKIQRILKEKARLEKLDLSHDLRRADEYLTELELSRDLSQYIIHVDCDAFFAAVEELDHPELKTVPMAVGKGVLTTCNYEARKFGVRSGMASFVAKKLCPELVLLPQNYEKYTAKAKEIREIMAQYDPLFESASIDEAYLNITAYCSENELDPEEAVQRMRAEILENTKVSVSAGIAANAKIAKVCSNKNKPNGQFRVPNDRTAIMEFMRDLPVRKVNGVGRVFERELDSIGIKTCGDIYPQRALLTKLFGEKAFQFLAQCYLGLGRTKIEPVETHERKSVSTETTFHAIEDKEELRKKLRWAADELAKDLERTQFKGRTLCLKVKLHTFEVLTRQTAPSRAVYRANDLYAFALPMLVKLEKEIPGMKLRLLGLRVSNLVSTKKLGINFFGVAQPKPIPAQPPNTNAHVCDSNVEHDIGAEEAFENAARQEQQDEMNDLEQLSQEAAGLSVTLDPPGAETTETTVSTTAESVDPQPEQWECPICGRPQVADDRVFNDHVDFCLSKQTIREVVQDSTSQEATPIPANNKKRKTQAQPSSADVDPRQKRLFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWN7</accession>
    <name>A0A1Q5SWN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="378" mass="43002" checksum="3A90925DC74C158C" modified="2017-04-12" version="1">MKRLENILKETGEQLGGKQVPANPGDKLTMHYDGHAQGWGTAVECQDDACKSSVAAHRTPDPNHVRDADAERRILSRPSSRVSDPVVIGPWAFSKSSSPFWNFLFCEVFCLTHDHQLWTPQNFRTVLAILDGTFFIPLQAFSPLFQQPLAIEPTKKSNMLNSGGVTVLRLSPDMVVKYGPQVTTSTEAQSMMFVAEYTKAIPIPKIFAYCTYGPLNRDIDDYGSLFDTYIFMSFVKGQTLDSTWDSYDELTKTRIAHQLKTYMNELREIRSEPYIGSVNKGPVRDQIFDNFYVKGPFESEEAFNGTIMDVYQANSPRRHIRSFLAGMLSQKRHSICFTHADVRPQNIMVLGGSITAIIDWELSRWYPEYWEFAKALYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXH0</accession>
    <name>A0A1Q5SXH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_12706</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXH0"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="71"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO92721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="494" mass="56438" checksum="EE79450D7DEC4BE7" modified="2017-04-12" version="1">MDEHDDFDSVSWRNDPESDASRPTTSGTDAEEAHKYDHDTNGKRRMSSAHEEPQAGPLADAVDLAGIGDGVLECRVDSPLKENDGTKDAYISYLVTTNTDFKSFQKPEFSVRRRFTDFYFLYKTLYREYPACAVPPLPEKHKMEYVRGDRFGPEFTTRRSWSLHRFLKRLTLHPVLRRAPLLIIFLESPDWNAHVRLHSNRGATTTSSENAGTGIFDNFTDTFVNAFTKVHKPDRRFIEVKEKADKLDEDLSHVEKTVARVARREADLEADYTDLATQFRKLVPLEPAVEMPLQVFAASVEETARGMHDLKDHTDQNYLGSLRDMEAYILSVKALLKTREQKQLDFEALVDYRNKAVAERDSLAANPAAYYASNPLTSSPASFIRSKMEDMRGVDHEQSRRERVRKLELRIDELTREVDSAKTTSEMFDEEVVREVADFERIKAVEFRDSLGALAESHIDFYQGVLSTWERFIAEMEGDAEGGLEADSHAAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXX1</accession>
    <name>A0A1Q5SXX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LYR motif-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXX1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXX1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="68" mass="8162" checksum="62AB81E49F744ED9" modified="2017-04-12" version="1">MVNIELRRQVINVYKELLWLGREYPLGYQYFRDRLHRAFAGQAHLTDEDQIRQGIARAEFVKKEVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYW5</accession>
    <name>A0A1Q5SYW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9847" checksum="D3D7EDAD70E7BDED" modified="2017-04-12" version="1">MKSLIRRLEHLARFRMTRELANAGVRPGTLSSLISIQVKNVRESQKVSDEPEEWLPPAEIGEWITGIHEVPEKTMFRIIIENRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0K3</accession>
    <name>A0A1Q5T0K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0K3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0K3"/>
    <dbReference type="OrthoDB" id="4526754at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="266" mass="27110" checksum="9054155BD0EDEBB4" modified="2017-04-12" version="1">MSTPGSIKTYTSAPLNPNKTEEETQATKVQPQPQPATAIEAETTTATQPQTTSATATAPSYSPIYSAVQPEALPAQAGAAPSLPAPTAAVGGSQANLMPTPTSTLPTTSSTQSPPPPQPGAVPQVQTTAAQSIVPPPPKAGQAVTISPSLPSTAQTTTAPQPSTQFTSSYAYHRSPHTTSDIPNSTSTPYSSVYQAPASGGPAGSAGLPLHYSSGGGGGANSIFPEDDEPSFFNTAKGWMQTAGSKLVEVEAEVWKRINNAHEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2E3</accession>
    <name>A0A1Q5T2E3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-threonine protein kinase 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2E3"/>
    <dbReference type="OrthoDB" id="3980126at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41078" checksum="B5BF18AD73BE1306" modified="2017-04-12" version="1">MTLRLTSAPVSGVKKRKSTPKPRSSPFAAHARRRPSSATTAAVKAADELIDDDPLPDIGGSRFISETAEAHNVVQAIQSIRMRMFDELPQRAGMNSTRIAEVLNLRRSLPPLASVAHVHTLLNAPTQVEREIVELVQSGRVRRLIVPGRGSDAAGLGDCLVLAEDWEDMVRGSTALEDELKEKFLDILTRIGSSSALSQSVFTPDEYRALIRAGFLVSSSSYTQASLNVASLPNLPQAVVSSASRRGPAHPSDTDRAVQTDAQARAATLFLSLPNTGTYLRLLGTGRAHLLALLRRSTCNEAPLKLLKDRWDGAVETEKSFHLAKRARGEFAGILPGRTKKWKDLYGMQFRWVLEEALGAGLVEIFETGSVGPGIRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2H4</accession>
    <name>A0A1Q5T2H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_11649</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2H4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2H4"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="23"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="22">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKO94382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="743" mass="83380" checksum="E3092779616B326E" modified="2017-04-12" version="1">MAQSSSLDVLLKGSSGQSTRGLLRIIILLTIAAAAVASRLFSVIRFESIIHEFDPWFNFRATKYLVQNGFYSFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGIIYHILRFLTIPVDIRNICVLLAPAFSGLTALAMYLLTCEMSTSPSAGLLAAAFMGIAPGYISRSVAGSYDNEAIAIFLLVFTFFLWIKAVKNGSIMWGALTALFYGYMVSAWGGYVFITNLIPLHVFVLLCMGRYSSRVYISYTTWYALGTLGSMQIPFVGFLPIRNSDHMSALGVFGLIQLVAFADFVRGFLPGKQFQKLLTAMVLLTFGLGFAGLVLLSVSGVIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNFLIWLFPAGVFMCFQNLKDEHVFVIIYAVLSSYFAGVMVRLMLTLTPIVCVAAALALSGILDNFLVMTKPNPESRAKANAEDSKSLRSTQKPVVGIYSYFSKAVVTGSITVYLLLFVAHCTWVTSNAYSSPSVVLASRMPDGSQFIIDDYREAYYWLRQNTPDNAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPILRQHDVDYVLVVFGGLLGYSGDDLNKFLWMVRIAEGIWPDEVKERDYFTARGEYRVDDEATPTMRNSLMYKMSYYNYQSLFPAGQAVDRVRGTRVPTESPQLNTLEEAFTSENWIIRIYKVKDLDNFGRDHNNAVAFDKGLKRKRASKKKGPRVLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Q9</accession>
    <name>A0A1Q5T2Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Q9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF28">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="258"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="667"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="733" mass="81665" checksum="3B08444950849899" modified="2017-04-12" version="1">MSVSDRLEEIIQAQARLIEMHVLQSQPSMGREMTQAGSLSYSSPSEPSAVHGPSPRTALYFNDPASSVNLPSRRADVSITSPSETSVKNLVQNSLQNGGSAPSMSSLPSIPNAQTNNDYTGNESSLKVPVSLFGNQEQSLADPDLDLPPYDLLYALVDLYFEHINSWCPILHRRSTLDTFFGPSPLEEADRMVLYAIVATTLRFSSDARLNDLNRKRYHDSSKQKVLLYGLENSSVKALQALVILAIDLVGSSNGPPGWKLLALITRSVVQLGLAVESKSSLIAPVYPSIYTLRAVTLSEPDSWIEDESRRRLFWMVYLLDRYSTIATAFNFALDDKDIDRKLPCKEEFFMKNQPVETRRFHCSSDRADYLSHAENVGSFGLYMEILGILSRIHLFLKRPVDIGSLSDVEEWQATYRKLDSELTSWEFNLPVEYAYENSSRLFAAGKQSRSLHSDWVQLHATYQTAVIRLHSSAAYPTTRSPIFTPSYSASQRCLLAVDNILSVTRFVVENNMLDKLGPPFAFTLWVSARLLLVHGSTIAHTVSHDILFFVDTLAHLGQYWKVAERYSNILQRVLDEYGEYQQSAATDGERSTPSTVKILADMRRCAFDLDFLISRQPRESPSSMSNGGNDATRPSNSTIPPRNLAPNELEYLDVFGFFNVPRVPPARAPDPNSANPGHLDMSESVPNPMSIHGLTGTGPVVDGNGNTNTNEFNITNYLIPTPETDWLFRPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5K2</accession>
    <name>A0A1Q5T5K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5K2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5K2"/>
    <dbReference type="OrthoDB" id="5402392at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="544" mass="61240" checksum="A0547E614FF1932D" modified="2017-04-12" version="1">MAQSNEPSTHIPPFAKQLAPYVKPRQEALRIRQALTSYLRSFIVFADETDPSSYNQSHLALCAPTATDVKRIPADLPGLRKEYLKALQANVAARKDYRAVSEDIVALRRQKRQRAPKSRPVETVDPQEPGDLQEYLQLLRDRRRHTKLQVFQHYLEELKAKEADRLGDIDTRESSSQQQQQQVLHQTEGVNAPMSNRNGGGADLEDLVHKLERAVVRARTRLDQERRLFEKVKVQQASRNEASSDEVPLKIRALQRTRDELVQWVEERLVTEGDPDESLIQDLDPEEIEDAQRLLEYQKVQISEQYALYLQARRDLLDAASRACQPVAVTAPSKLPTRPTYKPELFSEEIPAPDPLDVLSYTNETLLPLSKSQKALALQKSYLTGLLAKEKSTTLRALHRLSDESHLLPEYPILARQPRFKHAVAALNPRHSPQSTDQPDKVVDLAEAWAFASDAAAANERDYVQQKVMLGMEVAQDARKLLDDVYGTLNQDLGGAEGDPDVSDIWASEARSTRKAGMGLSGGSRLEKRPKGPWSGLNGRVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5P2</accession>
    <name>A0A1Q5T5P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5P2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5P2"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="55198" checksum="401965FACCC87C8F" modified="2017-04-12" version="1">MNAATRRAASNALRRSRTSIFSTYSRRWNSTFAERQWSTPLARTLASAMKVTGPIPIAAFMRQVLTSPEGGYYTSREDVFGKHGDFVTSPEISQVFGELIGIWAIAEWMAQGRKRSGVQLMEVGPGKGTLMDDMLRTFRNFKTFTSSIEAIYLVEASGTLRQVQKRLLCGEEAAMEETDIGHRSTCKYFDVPVIWVEDIRLLPHEEGKTPFIFAHEFFDALPIHAFESVPPAPENETPQEVQEIMTPTGPQKLLKPLKVANTPQWRELLVTLNPKAVEENIEGEPEFKLTKAKASTPSSLVIPEISERYRKLKSQPGSTIEVSPESRIYAADFARRIGGDTIPAKPSKKNPVPEAPQKTTPSGAALIMDYGTMSTIPINSLRGIQHHKNVAALSSPGQVDVSADVDFTALAEAAIEGSDGVEVHGPVEQGDFLQALGIEERMRQLLKGVGDEERKKTLETGWKRLVEKSGGSMGQIYKVMAIIPENGGRRRPVGFGGGVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6K0</accession>
    <name>A0A1Q5T6K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6K0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6K0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="354"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="712" mass="78686" checksum="3256800F76B25F51" modified="2017-04-12" version="1">MQYAPYASDIELPFYTALASHKINHDKLNDSARSVLGLYEIRSTDADNASCRIQIHGNALVNTEAPASYYRAEGMIKNVNTIEDYRNMDKQQMILQAGKTIWDAINDGTIYSCPSLLSSFIILSFADLKKYKFYYWFAFPAIHSDPSWVPVASAESQAAGAPPGEHLASQDSAALVDAVQTWSYGVDSRQRGFFLARKLRTSSGNSSQSSWRIAELSEYEKDFFTGAASEDRYVCFADPSNYENAPGWMLRNLLVLVKQRWGLDRVQILRYRDVQSKRDQGRSMVIRLESKPVGGDATSIAKPELTPIQMPKITGWERNPAGKLAGRIVNLTEYMDPTRLADQSVDLNLKLMKWRISPSLNLEKIKHTKCLLLGAGTLGSYVARNLLGWGVKKITFVDSGTVSFSNPVRQPLFTFSDCLNGGAPKAHRASEALKEIYPGVETSGHLLSVPMAGHPIMDEDATRAEFEALQKLIDEHDAIFLLMDTRESRWLPTVMGKAAGKIVMNAALGFDSFVVMRHGISETGDAPANLGCYFCNDVVAPANSIKDQTLDQQCTVTRPGVAAIASALLVELLVSIIQHPQGAAAPAPVTRSDDRGDHPLGLVPHQIRGFLATFENLTVTGQSYSCCSACSDRITGAYREQGWDFVRKALNERGYVEELSGLKEVCESHRVMTKSPAFEILTNDHQVQEKAEAALADVEWDEASDNDEIEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T887</accession>
    <name>A0A1Q5T887_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T887"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51002" checksum="EB169F61B83C5DB0" modified="2017-04-12" version="1">MSSSEKSASPKDEEVNSDSLTTPIHHVKWYRSTFYNALILGLCNFLAPGIWGAMNSLGGGGEEKPYLVNAANALTFALMVVSCFFGSVIVKFIGIKWTFIVGTMGYAPYAAGLYTNNRFGDEWLVLLGAALCGSSAGIFWMAEAAIALAYPEPYNQGRFLGFWLSFRVGGQILGGAISLGINARRATEGSVSYTVYLIFIALQALGPFAGLLLNKPSQVQRKDGVPVQLQVTNSIGYELKTMVKLFISKKFLCIVPFICQAVYSEAVMFSYEGLWFSVRSRALGSFLSGIIALIMGNLLGAFLDNKSISLKKRSRYAFFFVVGWQGLCWVWASVVTTEFHKTNPVYDWTDPGFGRAFALFLFWVAGFQINYMYLYFVVGNLADDQEEVIRIAGLLRGTESAAQCVSYGLSSIAVMAAVGSVYLNFALWAVAIPSAWYIISQIGLFGDKKLERETRALRESSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8C3</accession>
    <name>A0A1Q5T8C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8C3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8C3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="199" mass="21722" checksum="FACE6E1E004F33DA" modified="2017-04-12" version="1">MVGNSVEVLGIGTVNLPAKISPTQTGPSSHGILRLKKVLHAPGVLCNIIGQPIVDDYQVTLSPGISSSGSITNLTDGRSVAYFKPMRSARFWEVRLSGPPVGPKVGPSPFSSSGLYMIHAFWPDSERQRFAALPASRQSQATASEHLTLAEKAWVKTHYGTEFRFLRDYGLSIFKDEDREEGRLILRAIMSDDGYESAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8G8</accession>
    <name>A0A1Q5T8G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10701</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8G8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8G8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="13">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="10">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO96526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="52781" checksum="200175E1A478DB5A" modified="2017-04-12" version="1">MSALQTGNGDITRQPLKPPLDDCIFHTTSPLSAIPDPYKVLGVDKGASASDIKKAYYGMAKKYHPDTNKDANAKEKFAEAQSAYELLSDAKKRENYDRFGSAAFDQNGGFDPNAGGNPFAGAGGFGGFGGGGFGGSPFGGGFAQDINFEDLFGAFAGGARRGARGRRNPFQEQILVGEDIEVQNNISFMEAAKGTSKEINITPLTQCGTCKGDGLKSGAKRSQCKQCNGSGTRVHFMQGGFQVAATCDACGGIGMIVPRGSECGGCHGNGVVRERKTIKVDIPAGVEDGMRMRVTGEGDAPPTGTSAAAGARTQRGDLYVTIRVAPDQRFSRNGSDILYTATLPLTTALLGGEVTIPTLDNEVKVKVATGTGTGDRITLSGMGMKKLGGRGGRFSPTGDLKVEFKVAMPKYLTGNQRTILEVLADEMNDKTAKRTMNFNKESPASPSESAGNGRDEGFLKSIWHKLTDKNCDPSKPEAKDAKDNKDAGKTDASKDDSKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8Q6</accession>
    <name>A0A1Q5T8Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8Q6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51104" checksum="821DC3726573A6B9" modified="2017-04-12" version="1">MSRTALIVKAQNLLHSSIASVTDDQSEDDLQDLEPPPERDFTWDEVSDDDSEVSRIADDINGLAVSLDSLNSYNASYLGFSSVPTILRVIAHLSPRIRQVVPPSPETWKTSAPVGGSPESNASCEIDELSLINAYFLHVHPITPMIDEVEFRQRFADDAVPENHKTSWLALFNMVLAMGCFASGDSQFNTWAAATLGRPGLGYWDPGTVLTSSTSSLASMDYGTISLTANEQFCKIATRIQERLVEMPLITSDEIHDFDTELLKWKGSLHVFLSDAQHCPPPLRVARAMLFCRFMTTRLTLYRPYLLSAAIHRKQWSAATQQGGALVSKCLEIARDGVDTIASDWFPNHMLCWNHAWHLFQIALVLILAAVSDTNGAEGERCNEYILKSLDILAQMEPFDAGATRGRRVIQLLRDNIRNREDSIPMVDFDVSNGLVLDLLDEEMMGGDAEWVNFLCGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8U9</accession>
    <name>A0A1Q5T8U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pentafunctional AROM polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8U9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8U9"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF26">
        <property type="entry name" value="AROM POLYPEPTIDE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="32699" checksum="0F037A7BF1EA37CB" modified="2017-04-12" version="1">MAQFSSSSNDAVAAKNFHIFGKGISFSISPTIHNAGFTHYDLPYKYDIRESSNIDGVAGLILDEHFGGASVTMPHKLQVHKLCTDQTETARLIGAINTLVVKGNGDERRIIGDNTDWSGLHRIMLDYATRIGQRSNVGLVIGAGGASRAALYAMHKAGIQRIYLVNRTLATAEKVREDFKSVFEITVISSLEELVEHPDVIVGTVPAETTTEDQFSAIFGMRGLCIDMSYKPRQTPLLSVAHRHEGWYTVTGVEVLLAQAYDQFHLWTGCEPPKEKMIEAVAQHERENARGGSKGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9N6</accession>
    <name>A0A1Q5T9N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9N6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="18113" checksum="DCFE7236FC8FB1F7" modified="2017-04-12" version="1">MRLSNIAIGTIVALCGQAFSQESRVGKGPQTIAQANGDSLLTAASKSKQPLTFESPTGEEDQTWFFIEDSDNQGQSIQNADSGKYLYCSGGSACTQSRQAQIFHPYHQKNSDTWGFGEISSQSVLTWTDENTLKLVKNPSNMDHSFFTIKKAVGKVPRSCSGYDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAK1</accession>
    <name>A0A1Q5TAK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="130" mass="14597" checksum="2DA848BF2AE52E67" modified="2017-04-12" version="1">MAIGAISHPIVDTWDHNASVINSMAQKHLVGCKRHANSLGMQGFEVRLFVTNQAIETILSISFWALSQDRLSFEPKPVKLVQQRAGGPRVPLSAYPDVTFDILRLDRRPTLHAFWADQGFIGIHYVISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAP9</accession>
    <name>A0A1Q5TAP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAP9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAP9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="545" mass="60552" checksum="1AFCD443944DAE3F" modified="2017-04-12" version="1">MAEHVLNSSVEVASRARDLRADLKTWEKEFASTHDGRKAGREDIKQHPDIAAKYKEYGRLKALESSLNRRENQRESSDAQSKKRKHASPTGPDAAQPLTTPRKSTKGLFATPSNNRNKQVNHVDEFVSPSTFRKLFSPSAHRQSIPAPSPLKAAIGPTPQRDGKALGLFDMLSESGGSTATPSAKKQKDFLAAGFQTPSKPKTFEPIAEVPEEEEEESTRLSRTPASSTKQFYLANLFATPTTMRYAAMVENDDDKADQENAPPVIGLATSPEPNTSETPSFLRRSNFNRLPPPTSNNQSAGLSPIASRKPLQFAGKGLSHLVQGLRAMEEEREDDEWDMFRELEAEQEAANFQVPESQAVQENHRPYKKKGQKRTTRRVIMRPVAPRPKTRPNPTLAPVEERSESEDELVAVLETQLPAGSEVVDETYNEENAADDMASLHTISDPESDGEEPDVDSDDDPEYGETSKPLARAKSFSERIKEAVSMSKPQTKEETVKAPPAPEKEEKAPKTRMIKANSQAHTNYRSLKIHHRGGSRGTGRFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAY7</accession>
    <name>A0A1Q5TAY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAY7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF48">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G06730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="555" mass="60634" checksum="898EDF7EB4EAC94C" modified="2017-04-12" version="1">MGSIIDAAPKGAFGLVMQNPYLCGVASFSTLGGLLFGYDQGVISGVITMESFGARFPRVFSDSGFKGWFVSTLLLAAWAGSLINGPVADRIGRKLSINVAVVIFVIGSAIQCGAVNIPMLFTGRAIAGLAVGMLTMVIPLCQFQKFAEVSITIGILVSYWINYGTNYIGGSRCAPNIPFTGGTASKPAFDPYQDVPARGCTGQSEASWRLPLAIQIAPAVILGIGMLFFPDSPRWLMMKERDDESLTALSRLRRQDRSSPALQNEYLEIRASIRLENTFAREHFPNLSGFRLHAAQYMSFLTTWARFKRLAIGCCVMFFQQFMGCNAMIYYAPTIFGQLGLDGNTTSLLATGVYGIVNCLSTLPALLFIDKIGRRVLLMAGATGTCISLVIVGGILGGYGSSLMDHKSAGWAGIAFIYIYDINFSYSFAPIGWVLPSEIFNLSIRSKAISITTSATWMCNFIIGLVTPDMLDSITWGTYIFFAAFCLLALAFTFFCIPETRGKTLEDMDLIFGDTAAHEEKERIKHIEAELRGTQIDEHDDFKPVDQHMEHVDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAZ2</accession>
    <name>A0A1Q5TAZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAZ2"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="11750" checksum="D9541B1867539231" modified="2017-04-12" version="1">MPVEAITSKQDFLTKILDANSGPIVLDAWAEWCGPCKAIAPKVEEFSTQYPQAKFYKVDVDKVPDVAQELGIRAMPTILFFNNGEKITEVVGANPQGIENGIKALVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB37</accession>
    <name>A0A1Q5TB37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-phenylalanine transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB37"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB37"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="422" mass="45996" checksum="E6F6609C5D53B1C9" modified="2017-04-12" version="1">MAVNQKLTALVHQYERTHPRSKEAYSRAKNVLPAGSTRSVLVSEPFPLVLKSAQGARFTTIDGIKFEDFVSDFSAGIYGHSHPVVHQAVQEALATGFSLGGITQKETELAEILITRFPSFEKVRFCNSGTEANTFALATAVAYTQRRKIVVFDNGYHGGTINFGASQNHMNLPHEFIIGKYNSIEETRPLLIDEIAAILVEPLQAAGGMRPATPEFLQFLREAATNIGAVLIFDEVVTSRLHYNGIQGAWNIKPDITTVGKYLGGGFPFGAFGGSSKIMDRFDSSDKSIAIHHSGTFNNNIFTMTAAVAASKLITPAELERLNRLGDGFREQANILIQKAGVDCMTFSGYGSAIGVHFTGSEASPLLDCFYFTLLNRGIAIGRRGFMSLNLMHTEASMDRLLEAASCFLEDFSGNFATKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBQ0</accession>
    <name>A0A1Q5TBQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBQ0"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="254" mass="28166" checksum="0A1563F6E75E287B" modified="2017-04-12" version="1">MSTLTRAFTKRNKRPEVSAPMPYRGEGHVRFNSGSIKRSNISGPVQLISTTNMLAYNAPDIHSSNSSSASSLRSGDDFDAISPHSYSSSITTPDVSPHESHPVDANPASYFPKRSVTMTSHPRSSTTSSSSNEAPMVPQRALSHTKRSHQELARKRSQHRMSPPPLAAPRSNPIIRASQDVFLPETHPFSKELEQVNEVAEEFGATHMMDEEEMVLVRKGLKKFTVDDYLTEIEDLYGSIFDDRLGPISMGPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCU7</accession>
    <name>A0A1Q5TCU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCU7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="8411" checksum="64600797F26DDAAD" modified="2017-04-12" version="1">MESSRDVEHLPVFPQVFVNGYDLRQLSKCRFKLVTITQKSQHVSYGFLLDTFIVLLSQHRKHMGIYTKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDF6</accession>
    <name>A0A1Q5TDF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="124" mass="13896" checksum="AE63F888CA0F99D4" modified="2017-04-12" version="1">MVPSREGYPGDRECLDHSLDLGCCSSAAVIFVQKKTSRGGLSMRQVITIADKGWTDIPTYIREFPFFATKGWKRYGSSFLLLTIFVNLLSSLISPLQAIFLSTKTIKTPTYPLEVFDLLDIPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDN3</accession>
    <name>A0A1Q5TDN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-pipecolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9433</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDN3"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF45">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="429" mass="46685" checksum="BEFFB2D81B164A1B" modified="2017-04-12" version="1">MSPSKTDSIIIVGAGVFGLSTALELKRRGYTDVTVLDRYNPPAVDGSSVDISRIIRIDYADPVYCQMAYEAYQGWKNEYKDHYYESGFALLSETPENDWITKSAATVRANGGTVEDLDDAATLVKSYPNIQSNLAGMSGYLNRRGGWADAAGSIQKLASRCSVEGISIITGPRGSVVSLLREGSRVVGVNLMNGSSLHASQVILSTGAWTTRLLDVTHAASSSGQPVGFIQLTQDEARSLDNTPVMINMTTGVFVFPPTPGSNILKLARHGYGYANEVTVETDGVKRTISSPKFDSSNSETGYLPEDADEDLRKGLRQFFPKFADRPWMNRRLCWYTDTPKGDFIIDNHPTLDGLFVATGGAGHGFKFLPILGKYIADCFENKASEELRQKWRLQPALRDASSGNGMKGDGSRAGPPLRNLTALEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDR4</accession>
    <name>A0A1Q5TDR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_9463</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDR4"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="489"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO98365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="688" mass="75390" checksum="D2D6BEDFEFA238E8" modified="2017-04-12" version="1">MAGWFSSTSPLDEQIERATGSSLEDISLNLEISDMVRSKSVQPKEAMRSLKRRLENRNPNIQLATLKLTDTCVKNGGTHFLAEIASREFMDNLVSLLKSEGAPLNPDVQRKILELIQNWAMAAQGRMDLMYLGETYRKLQTEGFQFPPKTEMSGSMLESNAPPEWIDSDVCMRCRTAFSFMNRKHHCRNCGNVFDQQCSSKVLPLPHLGILQPVRVDDGCYAKLTSKSYVPAGFADRSAFKNNSITKSSTMEPRGAKADTSFDDDLRRALQMSLEEAEGRGPTGFVPQTGNTPQQAKPVTAPAPGPSNVEEEDADLKAAIEASLRDMEEHKQKHAAALKSNPPPSTTFRDSSSTPTPLPKNPYELSAMEAENIHLFSTLVDRLQHQPPGTILREPQIQELYESIGTLRPKLARSYGETMSKHDTLLDLHSKLSTVVRYYDRMLEERLSSAYSQQNLGYGAIPGAAQYPTMPGVHAPDLKSGAENYYYTNAPDTPRASTYASRQVSNSGYDAPPSGVTSPGYPQPAPNNWAQNPYPSLGSPPPQSNAIPNHPAPGSAGAPQYYAPQPEQDPSQSHYSETPYHPSSVMRRDSQYQASAPPVGPSAPEQHSPEQVHSPTYSSVNPAGTTLHQQPPGAPQSYYYQPQQPSTVPSGYPPMTAGQPGAYPDAPQTQPSASHQPARPVEESLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE40</accession>
    <name>A0A1Q5TE40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE40"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49951" checksum="53EDE0C257580BC8" modified="2017-04-12" version="1">MLGTAEEYVKAIAHHSQQSSAETLYPGEIYETLKRFLEHKSSDESSNFAWLVSPSSSSQQTPSDKQSLSDKHSMFDTTRNPGRSEGFSEPDPCVEALKSNIEISHPQVLFLRGHPSPNWISKIGAFCYADPELFRWFLRYRSEQAIACTDAGHNFTQGPPLPWLRDEPQGLPVTLLPIIQYKTRCALKSRSINDSDTGSAKERNTQSLAIFPEGYGRGLDWSLAKSDRFHILSDVFRLAAFSQKQLLNVMKEKILNETDRLSLSDENPTLTNLLYFRNILQDQLSTASYMLQLTDDQTCILQNGRRSISTDQKSMTDCSLAEMHSIFQDLHSQAELLYEKCNQGMTVISNKSMLAESQRAIQQAKLVTKLTIVAFVYLPFTFTAGFFGMNFRELGNGSISLWIFFAVSLPLMFITMAVFILDERKMKSFLRILGFAEEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE70</accession>
    <name>A0A1Q5TE70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE70"/>
    <dbReference type="OrthoDB" id="4361430at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="74" mass="8052" checksum="D3AB8BC0B347B1E2" modified="2017-04-12" version="1">MLHHCPEMGVSKKPSFVAETDSRMLLEAGEAKPIVEADGSMPVIKADSRMVSKDQTGHPPQYEALPQSEGSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEN3</accession>
    <name>A0A1Q5TEN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000667">
        <property type="protein sequence ID" value="OKO98680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEN3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="406" mass="43427" checksum="87F9B4451365D016" modified="2017-04-12" version="1" fragment="single">LNHLHFEVLALTINGDLLWKISSIHDLYNVHLVNKAFYAVVLPVLSKVMSRSSRKDGVPWLHAAAENGWSTLANRLIVSGADMSATAEDQATAFHWACGLGHVDVALLMIGQGANINQKDRTGVTALDGAISNGHQDIVDLLLDAGANTNSGDENGMIALHYAACHGHLEIINRLVSRGDDVSARDHDGWTSLHYAAWGGHESAVKTLLGHGCDVDARCLKGKTALWVADNVGKERVGQLLIEHGSEVNINVGGWTLLMEMVKREEEGMVKLLLDAGALVNTRFWTWWTALHEAAMRGHSVILQLLLTRGADIEAKARSGATALIESAGGGHIDVVSLLLQYGADVEAKDRAGQTALHLSAAGGHGTLVSLLLKNGADPGAKDMSGRTPLDEALRGGHKDVWRMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEN9</accession>
    <name>A0A1Q5TEN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEN9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF557">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C1039.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="94"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="37584" checksum="2CCCF4690C08E9E3" modified="2017-04-12" version="1">MTSHEALNPIHPAVLPHLDPVFVNLYNEHVANTPAGPIDLSVLRTKYSVLYSYGTGPAPDCARVYDSEVAGHNGDLIPVRVYEPATPGPWPVHVDFHGGGWGLGDLDTESHICKHICAKANVCVIDVAYRLVPEFAFPIGIQDSFAALEYISAHGADKFNIDPTRVSLGGVSAGGNIALICAHLARDAKIPLKLVAVGTPTIDDISKYKSTADAPWPSMQEMEHAPTLNWARLKWFDNLKWQSIQPKGPTRDAQLAAVKWYANALQAPDFTGLPKTVIYTAGCDPLRDEGEAYARKLIEGGNEVIQKRFAGVPHPFMHMDKDLWQAKEFIDMTADHIKATLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THI0</accession>
    <name>A0A1Q5THI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12314" checksum="14682FC6AB268B01" modified="2017-04-12" version="1">MLDNNLRILQLNIMKSRAGMEALISDHQTQNLDVLLIQEPYMTTYRTHRRLDLIPKSWYFGKPEIRLLAPGCALPDLTAQRALQAARGSDVMRLSYFAEHYGLLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THV9</accession>
    <name>A0A1Q5THV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THV9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="253" mass="26526" checksum="96FA455145A848CA" modified="2017-04-12" version="1">MPTKTPTQSDFPPNLTVTITLPPSTPASAPTPNILLLLHGIGDSAAGFTSFGRAINLPETTVLAVQAPAPLPFDLGGFHWGDDVSFDSRTGTLDMDAGFTRSTSLLANEVIRQTLVQKCGYQLREIMILGFGQGGMAGLAAARELGSTGTDGKASGALSGVISIGAPYALSGARSGAKNRSPVLLVAGRDSEVVSDGAVRRTKEVFEFVEVSRYARRGDGMPSNRDEMLPVMQFFARSLRSQQGVPKGSVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THZ4</accession>
    <name>A0A1Q5THZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beige protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5THZ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1662"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1830"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2255"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1559"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1559"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1614"/>
            <end position="1636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2467" mass="276963" checksum="93EFE9F6CDB2416E" modified="2017-04-12" version="1">MAPPPLSSPSPSGSTERLAEELAPTVDQLKTLTNEKPLTLSQALTATEPLLRLRHTFIDDAHPRAAKDAFRQLAGFQTLLELTGQLAELYDSTTLSKEDRKNVIGIYKDVVGTLAEGLKDHFGNKRYFARRITSGGTTVLERTLTVLVKKIDQVESDAQQLYGAILAAALCQETVAGIFVALSAKFPQSTNSASPKDVRDAVDKYMGSAETVEVPELLGPLIRVWVTHSASPGNEILRLSLPACLSQLATQSRRNVVALHATGMLTSILPLLFDAGRSDTERELYQDLARYLSVQGMNSLEDAVVLYRRAHENPGVLKFLLSALKYSKEPPSIQFDLSLHGFCSVEFATLGRPFPPTASAGYTLAAWVRFDDFDLNTHTTIFGAFDASQTCFVLAYVEKDTRKFILQTSIRGPRPSVRFKSTTFEADRWYHICLVHRKPRPASSSRASLFIDGEFVEQLKIEYPSVPISNHPHRSPRIQAFFGTPQDLAMRLGKDVSTSRWSLANGMLFDEAYSDDLVAVFYNLGPRYFGNFQDCLGSFQTYKASATLNLRNEHLHPGKEEDSDIVTAIRRRASTLIREGSILINLSPVAVLDDDDNNNVDESQLIKCLSRQAAKSLQQLTKAGSNAVAVNGGTPAINDGLTQPQGVGVLTGEPVVAVPWSLDDASWCLGGCAAVHLSLVQAANSAETLHLAVEALYEAVQDNWRNSEAMERDNGYGILASLLREKLGFQIGNAPTAGRSTAVSTKDDELNTLMLELLRLTLAFVGYDFKHPNHSIISNPLAYRVLLVDMDVWRYGEPQVLDLYYSQFRTFVSDSNYRRFNARRFGRMRVNKKLLETLKGDELTKDTLMPCISSFRALLESNLSPDLLRSLALSITYNLHRPKPPSALQKKKSIRFAPSSTRPPSSKSDSGKHVSSITLGIEMLRLYSSILCNSLDPTPLRKFAKAVTNKWLLYLSCEDEAEVVVHAVKILARLLVVHGSGYSKKFSDKNGGYTVLEYHLKRWWNIPALWPICFSILFGQDIALMDLDQPFDAPKLINIFLAGGDLRIAFPEMLPVILASDVIAQLECYVQELLAILYPTVVGVDSISPNTEMNSRYSGLSFDDSNLVLRPRSSRGNISTALQASMVDSSESPEESTESLQRRSSFIFVSSDKVKHQPSPARIRRVVNLAFSGEGATTGHPLVKAIAALALDVFEDQLLERKDFSGLGLYQKTPPGFLEHQAYFNSWIFDSLMSRLKEVPASQPQLLHEPRTLTNLARFATHLTEAVYEGWFINGEVTSLEYLGVILEYLQRPDIAHLKSIRLCTQAVSTLHSMLYKIVLFQLSEADDIETLPVLKRLNYWQVVLLAAAETQSKHLQLLCYLLYTRLISTETDIRLAAASLWRIILVQKPAEVANLLSHGPASLQRRLSEGFEALAGLDDDSFLQWIDDQRDDLDALFFGILSRQWETFVQEENAKSEDSAKNRITKRKDRLKQWAQLQKYDEDVIRKHDATLPHWISNISASEFLKSQRFLQDLQDNSVFMWSAFSNLLVDLQRPGGLLVEEKDRKFRLDQTEGRSRMRLRFVPDDSGERQDYQPKRKASEPPAPKLDTRVRALSAGEVASTPTAMTAEPDAVEPRQQDGDADNSDDRSGFEEENFEMIHDPKLEIEDYEDKNRRVMRSLHRGDQVQNVCNMSRIIGLEAVEGLLILGKDCIYILDNFFQRADGEIVNVWQAPPDERDPYVRMIAGRESNDRRSQEHETRSWKWSDLVSVSKRRFLFRDVALEIFFTDGTSYLLTFFSAPVRDNLCNQLGNKAPQVTGSAGHSRPEDIWRFETLRSQEDAPQSLGSKFASVFGHLPANPATRKWVRGEISNFHYLMLINTLAGRTFNDLTQYPVFPWVLADYTSEELDLTNPKTFRDLSKPMGCQTPDRETGFRERYNAFAEMGDDKAPPFHYGTHYSSAMIVSSYLIRLQPFVKSYLLLQGGTFDHADRLFYSIRKTWESASRGNMTDVRELIPEFFYLPEFLVNSNKYDFGLLQDMTTAIDSVELPPWAKGDPKIFIEKHREALESPYVSENLHHWIDLVFGSKQKGEAAVEAVNVFHHLSYKGAKDLDAIDDPMERLATIGIIHNFGQTPGQIFQRTHPQREDQRYRVPRLDTLAESLTQMPLSLLDIEERVATLSMKQDRLLCTAALRLNVPPAYDHYMEWGFFDGSVRFYSTDSRKLLGHFEHLHVGQLSHASFADSRTLITCGTDCTISLWTVTATSRSVDLQPIGSLFGHRAPVTVLAVSRSFSALLSASTDGHIMLWDLNRRGFVRTLPAEGVVDCARINDVTGDIIACRGNRITMYTLNGEVLVDQPVCDSPDDHVLSCVFYEGVHNEWLERELVLTGHSRGVVNIWSKVIRNGGFELELIRQLHHTDNSRDNGANIQSGISCILALPQVVYTGDEAGRVHTSIAGISKDMGQQQHQHYISTSTSTVFQTPGTPTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI18</accession>
    <name>A0A1Q5TI18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8073</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI18"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI18"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="28477" checksum="7FDC76AC5094A565" modified="2017-04-12" version="1">MASHRADASNFLDNRGYSGPLVRGVNPVTLFEKAVRDRITDSYYWKEQCFGLNAATLCDRAVELSFVGGTYGVSEKPSPFLCLAFKLLQLNPSRDIIREYLNFSDPGSDDEGENPDNGVVQTRGDFKYLRVLAAFYVRLTFDAVDVYKTLEPLLLDYRKIKRRVRDAYTLTYVDQFVDDLLTKDRVCGTSLWKLPPRQQLEDLEMLDERISPLADELEELDRDSNDGEEDADRGRSDDETSSRREEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI35</accession>
    <name>A0A1Q5TI35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Versicolorin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI35"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="27732" checksum="FD273F8CF04C1773" modified="2017-04-12" version="1">MTENKELTGKVALVTGASRGIGAAIAIKFAQRGANIAINYVSSSTGADSVANEVRTHGVRVITVKADVSNQAEVSTMFEVVKREFGRVDIIVSNSGIEHFGALGEVTGDDIDRIFAVNVKGQYFVAQEAYKYMEDFGRVMLTSSISAVKGVPGHAVYASSKAAILGMAKCLAVDFGPRNITVNVIAAGGVKTDMYDHNSPKYIPGGKDMTPKQIEDLLSKWSPLGRVGLPEDVAGVAALIASRDSQWLTGQTFHVSGGAFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TID9</accession>
    <name>A0A1Q5TID9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="13">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_8200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Deacetylation of xylans and xylo-oligosaccharides.</text>
            <dbReference type="EC" id="3.1.1.72"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate esterase 1 (CE1) family. AxeA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TID9"/>
    <dbReference type="SMR" id="A0A1Q5TID9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TID9"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029038128" description="Carboxylic ester hydrolase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="346"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO99983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="40285" checksum="EDDDBA26F18F5419" modified="2017-04-12" version="1">MKSLSFSFLVTLFLYLTLSSARTLGKDVNKRVTAGSLQQVTGFGDNASGTLMYIYVPKNLATNPGIVVAIHYCTGTAQAYYTGSPYAQLAEQYGFIVIYPQSPYSGTCWDVSSQAALTHNGGGDSNSIANMVTWTISQYNANTAKVFVTGSSSGAMMTNVMAATYPELFAAATVYSGVGAGCFYSSSNQVDAWNSSCATGSVISTPAVWGGIAKNMYSGYSGSRPRMQIYHGSADTTLYPQNYYETCKQWAGVFGYNYDSPQSTLANTPDANYQTTNWGPNLQGIYATGVGHTVPIHGAKDMEWFGFSGSGSSSTTTASATKTSTTSTTSTKTTSSTSSTTTSSTGVAAHWGQCGGSGWTGPTVCEAGYTCTYSNAWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJM3</accession>
    <name>A0A1Q5TJM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_7879</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="511"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="12">
        <location>
            <begin position="828"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="818"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="983"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1024" mass="110650" checksum="5B1829CA209F9A41" modified="2017-04-12" version="1">MSNFLNQDFGSDEEDDDFNPPPAEESDVEDAKPAKRRASSEDAADDVKYDGGAAEDYDAKEAVDDDEGAEDGEENGDEDDDEEDEDDEQAVEHPRKRRRGGVHSFFEEEAGVDEEEDEAEDEEDELAEFGTEMHPDDLDALPAGAETDDRRHRQLDRQRELDATMDAEKQAQMLKERYGRNRAAATDALVVPKRLLLPSVEDPSIWGCRCKPGKEKEVIYSIQKRMEERPANSRNPIRLISAFERGNIMQGWFYCEARRQADVTDALEGIAFYYPSQKMTLVPVKEMPDLLRVQKSEELMPGGWVRIKRGTYQFDLAQIEEVETNGLNVTVRLVPRLDYGMNDDNAPMLGPDGKRKRAAVNKVRPPQRPFSEAEAKKKHAKHLSATSGLGGKSWSYLNDTYIDGFLIKDMRVQHLITKNVNPRLEEVTMFARGGEDGTANLDLASLAETLKNSTAEDSYQPGDPVEVYRGEQQGLIGRTVSTRGDIVSLQVTEGDLAGQTIDAPIRTLRKRFREGDHVKVIGGSRYQNELGMVVQVKDDTVTLLSDMSMQEITVFSKDLRLSAEMAADGQLGIYDVHDLVQLDAATVACVIKVDRESLRVVDQNGSLRNVLPTQIANKLAPRRDAVATDRNGAEIRNGDTVREVYGEQRSGVITHIYRSFLFLHNKAQTENAGISVVRTTNVVTVSARGGRPTGPDLTKMNPALAMQTPGGGNPNMPPPRQGGRDRLIGKTVAVRKGRYKGLVGIVRDSDDKTATVELYTANKPVLLPREILVPKDPVSKQTLEIGGRPSSRTPSYSGSGAQGGGWQGGRTPMAGADSSRTPAWGGSSSRTPAWGGLSGSRTPAWKNDGSRTSNPYAEGNRTAYGGLGNRTPAWNSGSRTPHDSGSGYDAFASGSRTPAWGAGGAGNRTPAWGGLPNSRDQRDFDDAPTPGGGYSAPTPGAYGAPTPGASAPTPGAWADNAPTPGGAFSAPTPGGLPKRGGYDAPTPAAFDAPTPAMGGIAATPGAGYADDDGGPRYDEGTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKJ6</accession>
    <name>A0A1Q5TKJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKJ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="593" mass="65259" checksum="FE5678E807CCF931" modified="2017-04-12" version="1">MRYNDPPITKADSAKNSEISSAQILYEPSQVWNSHVIPLVLDRFSIELVDTIKDSSMFATIPRIISTSQEGSPVYAVCDAIACAYLSSTTGTTAAMVNRTRAYATALRTVNTALDDSVQCKNDSTLLAVWMFVVYEAEHKLEIHVPQSFTADRSAVNFNHEKFHISINKHPLASRLPAPTDDVPSLQDGSSVFRKLWVPPNAPVCLDDYLTSDLPQLTLNVVSFTDATLVSLCWPHIAADAMSLRDVAKAWSLVLAGRQSEIPPMLSSGDDPMAPAGNNPLFLDTHVLEEQQVKGWWLLLWGLRFVFDLLWWRKMETRTAFLPWKVVNQLRSNILASLAEKAEKKIATEVTEEQAPFISEGDVVTAWMSLIVASSLLPSKSSRTVGISNAFDLRPRLPSIFPAKENQGSYVQNAVFPCWTNIPACDLIGKSDALGVAALKIRHSIKKQTTEPQIHALARLTRISLEQTHLPPMFGDTSSFLITASNWSKARLFEVVDFGPAVQIAQCTSKYQGSTLAMKKKSIGGNTGSGCQAVKSNPVYYCVDNVSPNNMLARNAFFLAGTPNGDYWVNGCFPNAVWKAMEGVLRDNLLTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL78</accession>
    <name>A0A1Q5TL78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TL78"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1473" mass="165481" checksum="E419D6514DBC224A" modified="2017-04-12" version="1">MRAPPPEVEDVPQVSFEEFAMRYRQSQRKRAQRKRLEKRLRATKVSIGNSARMIRVGNTIQRGLVEALKHDDKANFVALYHTLFDLQESCVSSALLDEHQDYLPDERELSPESELDRSSDFFHQLSPQSRADLLEILRLVRSDPQFLVDRLRSFTSAQLAAFTSPATTLDSGDPAFPSSSSRLRGQYAFNRNPAQFASFKNHAYAFERTDPLTILLCNVFAAPLDPESPEARLRLDVWSTVCAQLMSHGSSKFYPLIGQILSSWATGCNWKARPKFELYLMDILQTGAFLLEHIASPAGLDFAPDAWDPLRTDVAEEFFASAVDNLFRVLDDPDGGFPRAVLQFAKAVLRKMESPDSRSRFLEYLFVQWFFPKFLYSALTYPETHGLLLDFHIRKDAREKLLGQVGLRAYSQVFAVLRSMHHFSILRPSIKEHVDNMLSRFQSTVPSDSATTGLFTQRDHTIRRDSTSNFLLLSSTDTLTLLDALFPQICSPVHSSPASAGMPSWSTNVSPSYHLRPEPPMEPGFFRPNPELSPRPTSQSGSILSVDSSHVSVLESGIVQTAARIRFELSDLDEPSERARLEPPSEEHWTVFSVTNDGHGLTWSLLADQVNGPSKGSAIDSDDDTHSTCLGLEENHEALQTAIIRLVKESHVYDVDDYKRSPRSMQVASISLKQQFTQAMASSQNDSDFVGAHYWWNASRQLRQGTHPAASSSDTWILGPMHRSCTRSLENSMAVIERCENDFVSLDQSLHRLQTQVKALMATVSKVRTKMWYMTDVKNSMRYEEARHVTMALKMIYSARPYNTEMPEESRSRSGARSLGGSLFQKPEVQVMNMMKAPSSQGGPRKMSDEQVELTRKWLAHSGIENFCKGEERIHRFCYEVRTSINRLVGETMAETPVLWASELFQRERARYEGYGSRAFPGLSMPTTPRPSTNASEDSLHSSQLHGANLPVPDLLARSPQDPPSFLGSKSSIQSLIPDKYRATRDLPSIDVSSIGGSPGRAASTSTGDTYSTFWSAGQRQPMYAGSVSTAYSRPPSMFSEGATRQPRRTERKTHGKTVFMDELRQTLTSLLLSDLGSPVWSCGSETDAWFTSYLDQPRIQVQMQRHAAVRRFYSDYEERSKNLREKRRSSGGRRSRSLDNPRGRMRTDSSTDASSVIQETLKGDDDAAFSYKGVFHRLIEVFSRHGNPFVKLNALRDLRSLVVASLISSNDGSPAGPATRSMSETERGRANGPRSRATRQSFSEAHAPTMPQTGTAFPAMTPPESVTYGSRRSDYSTPSEDQIVATLRDLILEVKPKTLFRDLQYISAFVPGEQLNKSDRGTAFLQFGLAALSLKDEVCHSMVEIADRIVSQELMRRHAGADFYPRPSPAGHAIEDAAAMWIITAKEGNPVAQRELAILYLTHPERLQRVTLPLTRPRDTFKAEMMYRRGKDSKSDPQSMCLALHWMQLSANGGDLLARNRLREREEFDSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL83</accession>
    <name>A0A1Q5TL83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL83"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="178" mass="20443" checksum="F42A79E537728B60" modified="2017-04-12" version="1">MLIYGFSSHEDSHVILVVCVRRLWTVLEEVSFKGLTGRENVEDAILCDFHLRTDDGNAIGKIPEPDIPGCSRKSRISMYYVIRDDDRVPYLEIVIDVVFDRGLNTHGRLGRVKAILMLTHDDIESIKYKEVSFPQDSMNGPGSTVNYDQAMHGFWEHSSVRKRLFAELPYEKIVRKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM35</accession>
    <name>A0A1Q5TM35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM35"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="214" mass="23857" checksum="BD0C9C28642AD0CD" modified="2017-04-12" version="1">MVGPQKPGIDDVEITTPAGNAVLSVLDELVLQNFRPILRTGPDDDVLLNAIMLTFSFSIAAGHLNRQCLEYQSAALSSVRKRINSPNKSTMESTMGAILLLAGVESHLSLQLLSKLQKAKEDPTWNNLRELLIWLLHIGGAFAPTGSIRTAYKKLLHLSLSTRLAGLYTSWAELCAILRQFIWSDKAFMSQIRAFWEECIVEYRLEQTSRTPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMB6</accession>
    <name>A0A1Q5TMB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMB6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="7707" checksum="4DBA1285C606BE77" modified="2017-04-12" version="1">MQVQPPSPPIISFGYESLRGAAPGVVLRAIFCLVGVGAEDLIGEPGGGPCNLADLPFTWLHFRGPTTQLLNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMI1</accession>
    <name>A0A1Q5TMI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_7419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMI1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="60875" checksum="589DCFE711B670C3" modified="2017-04-12" version="1">MVVVGKQREENVAEPVLANLLADDHTPWYKKPNLRALYFILFPACMGIEITSGFDSQIINTVQIVYTWNKYFGKPTGKTVNGLPQYAIEANLKGFLGAAYSLGAILSLPFVPWVNQKFGRRWTIMFGSCVSLVGALIQGFANGVAMYIVARIILGFGIPFCIVAGSSLLGELGHPKERPILTSLFNSSYFIGQIIAASVGLGTVTITSNWAWRIPSLLQIAPALIQISTVLFLPESPRYLISKDRYDEAFDILTKYHAEGDRTSVIVKAEIAQIERTIKMELEESKQSWWDMFRTAGMRRRLFISAFLGLFTQWSGNTLISYYLSDLLNLVGITNSVVKSKINIGIACWGLVSGTALALTAPRFKRRPMYLTCACCLLCVYVAWTISMERFISTKAKSAAGLTIFFIFAYSPAYNLGYNALTYTYLIELFPYMGRSRGLSWFQFYGRGASFFATYVNPIGLARITWKWLLVYCCWLVFEVVFIYFFFPETQGRTLEELSFLFEDKDKAKEVAAAVHKKLEDDDDKKQDTAHLEIQETKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ76</accession>
    <name>A0A1Q5TQ76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="87" mass="10175" checksum="A0E92EA99E89444F" modified="2017-04-12" version="1">MEKMGEECRLGYGEDAVLNYGGKPNHNSPKSPKSLESHRDEKHTRPVIRRVQRVQLQRSKAGRERRQSAQWRYKPAIEWPEALPHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT14</accession>
    <name>A0A1Q5TT14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="120"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP03369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="484" mass="53473" checksum="1476F1CFA9E65695" modified="2017-04-12" version="1">MSVPDVTAANVAEILQNDRMVKVAGIDVDGQLRGKLMKKSKFLSIVSEGFGFCSVIFGWDQHDMTYYKELSISNKENGYRDLVAVPDLSSFRRIPWENNVPFFLVSFLDPDTREPVCACPRGLLKTVSAKAEAAGYRAMAGAEYEFYQFRAPGDHTSPERAASATASFLQTNPVESLPPLTEGMFGYSITRPLHNQDYYYGIFDACEQFRCDIEGWHTESGPGVFEAALQFGEAKEMADKAGLFKYVVKAYGIKHGITPCFMAKPRQGLPGNSGHMHISLVTADGKNAFIRDTPDPSPPYPDVAHLSDLGRHFLAGLLVGLPDIMPLFAPTINSYKRLVENFWAPVTVSWGLEHRAASIRLITPPTASAKATRFEVRTPGADANPHFVLAAIMALGWRGVEKKLEIPVPPLSKGEDTGGASDQGVRLAKSLKEAVATFTRPDSVAREVFGDTFVDHFGGTREHEIRLWEEAVTDWEVRRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU89</accession>
    <name>A0A1Q5TU89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU89"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="432"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="715"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP03791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="956" mass="105321" checksum="D456A909B17B5700" modified="2017-04-12" version="1">MTAVMNGYLDRVPRFKHLRNSISDKRTRECYSSIHDTISNLGRAVQLGQHRQLIDALDETFSAETLEAIAVESSTNKELCAALSVYLTTLEQTYAWPRRGTVATPRALCDHKLIVQVLYHEDLAAVLSQRRGLATETRGNPVPLSGLALAMANELLQLAEEARTKSIPLPQAVQDQVNMLFRNCSQDWYSQGDYRHAGSHEQFGRLHEVIRTNGTQRSVQEIFQDNGGIGYLHTLHALLHDLPGATGGVVRALQQLQTSVSLAREELFGMMIDEVIWGQTFAKFSKPVGYASLGAGGADCPMFRMLDALCGRHDPTAADALLEELTMRSRNFPPNIRSLIHDVASAPSLRALASSSSASPELRHSFAVFQQLMYSLYEMHRKKALRIVLALRAGQLYTSSGTEKAASPERQLAATLQSAMDVRFGTDALSRTIPAYGRVVSRILSSTGRVESARIRFRFDTPVVVGAGDAVIITPVVGGIRESRTYSVTSFSPSTDNGCNEHVVLSPTTSVEICCRNMGTVSSFLCSQRGDCTVRLALQPNPHFRISGNESAKEITLLIAQNGGVGLFCAWLSRQARLVGRYVLIVGVRRLDELLYASDIYDCAEKFGNQLQVIFCLSQPNCGDVQHVKSRGVWPFAGRVDKFLASESLPPARATYVCGSAEFGILVAKEIKGARLAKKSILSSRLSPIVTSKMPSLRLHVASSSRAAPKCKKTLRPISRWELARHNAPGDIWISLNGAILDISLLSIFHPGGEKTLMCRAGLEADDMFNSVHAGSFEVKSLLNELQVGYLQAEAPGENGLVHQCLDAIVQIQNDLTNSTRFEERPTGSIHQLPRVPPTEVIQGSWIQFTASWVAMLGKLSLCEEMTQALCGVMDDWFASMAQKQRAVYDSGFYDVKHCAVEIKRLFNAHEEAATAMHGVLDTLKHGLRWVRHDELPKMMAMATQEIIQQTKEKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D1</accession>
    <name>A0A1Q5U0D1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylhydrolase ARH3</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ADP-ribose glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ADP-ribosylhydrolase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">O-acetyl-ADP-ribose deacetylase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(ADP-ribose) glycohydrolase ARH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">[Protein ADP-ribosylarginine] hydrolase-like protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylserine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_6650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:77017"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0D1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0D1"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF24">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP05930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="319" mass="34991" checksum="7D1DC77AE06920F9" modified="2017-04-12" version="1">MTPSGRSRALGAIWGTCIGDALGGPIQFQKPGTFKPIKELEFVKPFNQPSGSYSDDGSMTLALAQSFVDSKGQYDHALSIQNYLDWFNHGRFSTTNKAWDLGRSTRVALRVWKAQGLDDLALAQQKVNEQLDQEESSGNGSLMRISPIGVALWKDSDRAKRLAREQSLITHPALACPDACEAYTQAICMAMNGNTKEDICKAITQFHFTHPALVTRFARYTSIADWKAKSPTDMHSSGWVVDTLECALWGFFKYESWDEGVLAVVNLGGDSDTAGAVYGGLAGVYYGYDAIPPRWVHGMQKGGFIRDIAGKFAEVVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1G0</accession>
    <name>A0A1Q5U1G0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1G0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1G0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21893" checksum="1C039A9DC4B0BCE7" modified="2017-04-12" version="1">MKGFLRSLGSSRRSSPGDDSEQDYPDDSPEAILLREMKTFCEASNQPGTQQGNEFVHLPRIVETAESSPAAAKEAAHRIRKYLSNPSNTPNHVQYNAIMLMRILADNPGHSFTRHFDAKFCTTIKELLRNGRDWHVQHYLRQYLAQLETNRHWDDDLQLLLQTWAKEKAKGGRSFVSTEGLGILRQEENRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1K4</accession>
    <name>A0A1Q5U1K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1K4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1K4"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="21868" checksum="7F1C23850E6C8B4F" modified="2017-04-12" version="1">MDLPDTTEMTTTTQNLNLLDLPSELHIQIASFLSYPDALALKHSCRHFYSMVYTGVHLKVNWLVERFERKLECPMEKCSFRTDEAFCNWRIRRIMERRRQHLECRRAPGGCWVVEGQTCHTDLVPLWLKGQGPRRVVRSLTTLVHEALLICFFAMLLEGLWRLTKNQVVNWLAHQAVADWCASLILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4P5</accession>
    <name>A0A1Q5U4P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_6038</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U4P5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="14">
        <location>
            <begin position="1280"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="519"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="823"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1059"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1611"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1984"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2037"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="576"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1123"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1624"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2046"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2064"/>
            <end position="2075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP07449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2091" mass="234989" checksum="357A351FE65E3584" modified="2017-04-12" version="1">MDLFRCFGDKGDVEDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHFLLSTNDKTIKLWKVFDKSLKVVAENNLSNEMTPAGAVGGGGLPRAPRGTFKDAGALKMPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRVNLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPVSCNWFMYASSKGTIKLADMRQRALCDEHAKLFEQEEDASSRSFFSEIISSISDVRFSHDGRYIVSRDYLTVKIWDVNMERQPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAENVMTGSYNNNFMIYPTEEQKETEIVLQADKSAFKAKKVGVPTPMNKGSGKKAGSRSGSPAGPGSRMKKETDADQIDFNKKILHMSWHPFEDSIAIAATNNSKSPSARPGVATLGARSPSSIRLANALYNLSIATVFDLGSRMSPLGKMHELTLLRFSTGPYHPGGQAGHSLPGLAELSQSHGAPHQPPAYGQHPAGPAHGTGHSLPGIGQAMSHASPQSLNRERERDSREREILERQRQEEMAHREREQIERQQMERQREHHPVQSHTGSIPLHQPVASKVPNSIHGPNGLLSNLGTNPPNGPQANVQQPGGPAALFGGPQMPHGDGTPRSYMQHPAGPPMMGYNGQGQQIPGNVAALAQGQQPILNVSGPIGFSLHMPWAHVPLVEQDALSYLDQVKVRFVDQPDVYNRFLDIMKDFKSQAIDTPGVIQRVSTLFNGHPALIQGFNTFLPPGYRIECGTEDNPDAIRVTTPSGTNTLSMPRAGRSLDAANDLGPSGGHGAHPRADYYEQSRPGWQQTPQQQPQGHQQGAPGSYSPGSRMMGPSAMYQQEGQAPPQDHHFGYQTQEAQGASALSHPQDHRGVAQLQGAASAASGLGRPSMLPVSGAGSNQTMSSLAGVGGMLQGGHADLNKRGPVEFNHAISYVNKIKNRFSSAPEIYKQFLEILQTYQRESKPIQDVYAQVTQLFNTAPDLLEDFKQFLPESAAHAKQQAQARMAEEAVPTSNLRGEPVGLPSSTPSRDVKMPPLGQFNVKDSGKESKKRRGGPGVGLSSVSGPAGVDAARMPEARGGPPAGSFTNGNKRPKHYHGKPSGADMANVSPTLIPALPEPVPPSVMTTPSQEEIAFFDRVKKFIANKQIFSDFLKLCNLYTNDLIDRFVLVKRAEGFIGSNAELMSWFKRFMNVEEPEDKTIDPKPQTEAGVVNLAHCRSLGPSYRLLPKRERQKPCSGRDQLCHDVLNDEWASHPTWASEDSGFVAHRKNQFEDALHRIEEDRHDYDHHIEACTRTIQLIEPICQQFLHMSEAERANFKLPPGLGGQSEAIYQRVIKKVYDRQRGEKIIRDMFERPCQVLPIVLYRLKQKLEEWKACQREWDKVWREQMQRAYWRSLDHQAIATRSTDKKLFIAKNIQADLQAKLEETQTMRKGGLKPPKYQMEMKFQDLDVLLDTAHLLCLFFDRSSNAFGADPSRLINFVKDFIPVFFGLDREAFLDYMDELMLNATPAEELEDQYGADDTSMASRKAVNTQKLDLLRETLERKTEKSNAQVQEDGVAPNAAPASAPATTQLATPDVRATSTAVSEPEDHFDVAELKWMEHPGQGNFNLEREYTLNEKYKKTEYHMYSNLTLLCLLRTFEILYSRLLRIKEQEAEAHEQVRRGLLPKPAHELCLIDRFPGDFFYDVDPKANLYKQIVRMCEEVIRGDIDQLHLEETLRRFYMQGGYLLYNLERIFSSIGKFVGMIFTADIKDRSSDIANLFFKEREKTETTHHQEMQYRKQVERLIKEGDMYRITYFPSDRHVTVQVMTNEDATLDSEDLTPEARWSYYVTAYSMRDPTEGVSYSDMRMPFLKRNLPHKLDEDEEYDRFYRRLQHHDGLIIRICANNYTILYQPPSHDWFWRSTVPILDKDADAEAIKAKEEEQNKEKTSTREKRHDRFVEKFVNNPNWARGLSKDKVDESNQRFRSWLNGTLEKEDSVPAETAEPVAAPAAPSATADSQSDVQQTTEQVDTDMADAEPPAATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7U3</accession>
    <name>A0A1Q5U7U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7U3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="3">
        <location>
            <begin position="137"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="689" mass="75338" checksum="544D10C85B318189" modified="2017-04-12" version="1">MALFKSLLASLTSWLPDSILASIKSPPLAAHLALLLFVLWLFWKSVFLLSDLWSLLNDLASLKSPRFAQAKDRLESGDREYRWIYGRDLWSLRFAIATMIIMQLLNVWLFLGQVELIYAAYSSTGVLDVFEVYQPVTFAPKSHNGCDLDMLLMEHSFGESYGVPFVGSYEPPSCKFDTVRINMTVTSSGHQYDRLALMYLGDAEVFRTSTAEPTSTGIVWTYIKEMSQYNALWTESQKLIFDLGNIITDVYTGPFNVTLTVHFSYTGNARSADIIYPISAKKSASNSASAFTVPTDNTTVSYTIPDTVSRAVVAISACGQSQEEFWWSNVFSEDTEDFISTVGELYGYSPFREIQLYIDGILAGVVWPFPVIFTGGVAPGFWRPIVGIDAFDLRQPEIDISPFLPLVQDGQEHSFEIRVTGLNITGGTATFADTVGSYWVVTGNIFLYTGDKTSSKALVTRSKTVPHVEAPAPKFTVTRHLAQNETGENDTLSYSVTAERTFIASSPEYSWSQKLSFSNYGYLNQQGYSQVNTQLTSGKNTISKLGIKSSSNETTFSYPLIVNATYGITTNSLTIDAWMERGLEIKSTGGPGLSTYTFVSGPSQLHTTQSGNATYKSATGSSSASTGNTADEFSGVANGVSYSRSVTAANGNVVSDTQGGAKKVYKDMTAFGRGSVRSMLGRGPGSPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAD8</accession>
    <name>A0A1Q5UAD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAD8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="14189" checksum="4D18B2EE5A2904DF" modified="2017-04-12" version="1">MKDDHRKIVYETINMLNSRLVAAEVNIESAMKKELDYEEAQVNRWKYMLSPQSINKSVDALEQWQKVFDLSWFLAISRVGPLIDGQLSEWKQSPVEDGRVPPYIHCRITAIGIEDCFKCRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBJ4</accession>
    <name>A0A1Q5UBJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012727937" evidence="1">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="20020" checksum="F563F218CD539296" modified="2017-04-12" version="1">MQLKNVILTVALTLTTSVFAATSASDLAIGLQNNIAGLDIGQKQTTLLLNHLAHHTAGVTADNVVSSYNATATTEAEDLAMMNMMEIDEAPGDAIQMVLCQAFHGFALSSIEANNAFIDYAMSFNKTQRKTLRDAIARNKDNVSAFLDRVASKALPFCVSTIKIDNSAMYASLDKASKALDSKESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC83</accession>
    <name>A0A1Q5UC83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_4549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC83"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP10084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="544" mass="60675" checksum="062CE3B2CC72328C" modified="2017-04-12" version="1">MSAASSKEDGTTRVVDIDATPEARRATEAEHQMSFWQSVQTYPKAVGWSILFSTALVMEGYDNALIASLFAYDPFQRAFGERQPDGSYQVTAAWQSGLTNGALVGEVLGLFATGIVVEKFGYRKSLIGALLACVAFIFIIFFAKSLPVLLVGEILIGIPWGLFQTVTTTYASEVCPVVLRPYLTTYVNLCWVMGQLIASGVLKAMLTRADEWGYKIPFALQWMWPIPIAIGVALAPESPWWLVRKDRPEDARHALQRLTVPGRDPNFNADETIAMIRSTNELEKRMTSGSSYLDCFRGVERRRTEIVCLTWATQSLSGSALMGYSTYFYEQAGMATNNAFTMSMALYALGAIGTISSWPMMSRYGRRTLYVGGLCCMMILLLIIGFLGIISKTSVPAQWAVGSLLLIYTFFYDATVGPICYSLVSELSSTRLRTKTIVLARNLYNICGLITNIITPRMLNPSAWDWGAKAGFFWAGMCFLCLLWAFFRLPEPKGRTYAELDLLFEQRVSARKFSSTHVDPFANERESPLVTKMEKPFTEVVEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCT6</accession>
    <name>A0A1Q5UCT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000370">
        <property type="protein sequence ID" value="OKP10270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCT6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCT6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="33414" checksum="2D584198518E5A45" modified="2017-04-12" version="1">MAAGITPPGSVLESPLTPPPTEEKPLSRSAQSVVKFLQLHLAGHRPQPWWERRLKPDHYTQVLRVLDADEPLRNYVEDKIRQLRQFQQIDGPVADFSKEVEHFATSRILIPEDTGDGRQSYSRREPDASFGHRQAHYPGVIVEVCYSQKRQRVSHLADEYILNTDGSVNAVIAFDIDYKGSKRATVTIWRPEYVTVDGVEEFRATAVVEAQVRLLQIHHSRRAEARQQSQTQLQGSINRVRPGVLKRPRPQTPPEQISSEDEGSVERKRDSKRGRRSSDYRPSSSSEDSKSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCX0</accession>
    <name>A0A1Q5UCX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_4263</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000360">
        <property type="protein sequence ID" value="OKP10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF1">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE C186.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="91"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="270"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="474"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="645" mass="70146" checksum="10E15681BA23F55F" modified="2017-04-12" version="1">MVDPQWINETCGSCEFCNDGDQQLCPNAKNSGYTVNGTFQQYCVCKATNAVRIPDEVSLDEAAPVSQNLLDMAQLTLMLLTTTAIAGAGGGLGTLACQYAKALGYRVLALSTGSSKQAMLVEEIGVDYFVDYIASQENLIPEIQELTGGGPHAAIVVASYVRPKGTVVVVGLPKNAVITADLFSTVLKQKIVKGSYVGSPAETEEALAIYAKKRFPIQYQTVSLEELPAVFEKMEQGKMQGRTVLKIPSPQTMVNDLIEKTPKFRPNEYNIGTLLASRLEEIGIKDYFVVPGDFNLTLIDQILKNPNLRMVGCCNELNAGYAADGYSRSSPARAAVVFVTFMVGGLSLLNAIAGAYSERLRVIVVSGAPPTDTFGQDCLIHHTTGLKERDQAIRMFEHVTTASVRLDLKANPASVLDQALLRCLENSLPVYIELPANLAEYSCDVPRPLILSRPRGSLPSLVQDALDLFTRYWREAQSPVILVGPLARHGLTRDTLLSFIEKLGCPVFCQPDAKSLVPEEHPQFQGTFWGSISDPACIDVVMNSDLWVGIGTRSSDYNLVKRPTPPMLDLSPDHLRAPKGNLISPATMADLSERIVLSNLTGYCMESHNSASHETIKCSCCMVLSDGVYQQQWVLNLPGQKGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD22</accession>
    <name>A0A1Q5UD22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_4219</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UD22"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1029"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1327"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1332"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1058"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1350" mass="152167" checksum="E08E934C63C90406" modified="2017-04-12" version="1">MEHPDIVSHDSDGSGSSDDFPPQYPLRANSSFGEPFIDGAQVQTPATTITSSPPSHSSSLGSSWSSTPTARPRGASVGASAVLDKVDPHAMATDLRLQRPSAPARTPSNTYAPQRRPPQYISLQSDRQRSSSAKRGTRRDPNAQYRAQEKAYVQRIRANPQAWYHHFDDAQSANMMVADADLEDPSPSSEVPFDDDSYDPDTQLFLPDDNMPTIEELKNPKNQERLEWHSMLASVLKGDVVRQEKQRLIDSTESKRSAALGHALWMGVRARACGRSIALQRKLIEDSRAQLGPLIEEIINFQIKGETEIGKPPRQQVEDVVAKVEKCEVLYSTSKEMEAANPRTASEEFYSSRAAIFAWHNITALINTELAVLQSWVGNDALDFSQPRTKHENSELSEDSSFLDRIMKEDGLKTLQGDHSMLNGLGRVIQKAKGTLIENAEAFAARHLPPYIEELLTLINFPSRLIQEIIRVRLSYAKNMKDPAQQSPILVDQMISQFQILMRVATHIKQRYLEISRPEPGWDLPPCVDENFDSVVLDAMKYYFRILNWKLNANKNTFKEAEILEQEWEFSYVIGRQFENGDIEVAEQFSALTAKSLQRLMIHFERELVPRPNESVADMDKRYKSILDSTRIRQRKLYRFSKFLCELFENATEYNLTTDIAYEFFEALLVSDHFLVTSPTSVGQKGVYLIAHHSLWNRPGDIQAILATSFREDESTKDGPHIPYVLVIRPEKPLAWAGKEMKIDFLEQPTDVRLGKLRLVVEGMQERLQNARMELAQLTGIQLDMAIEQRANLGRVNVELNKIKKISFKLSMAIMDSVAVIKNQLREKTWENNELIQACYAFATEFGKRSSNYVDSNRRAMNSARLVELSLDWVSFICDECDAADRKTFKWAVAALEFAMAITSSRHLLSMDEEEFSRLRLKVAGCMSLLISHFDIMGARSSLAAQAEKQRMEERAGYRKVGAGRILSDEEASKLIREQWLARVMEIEDRRVEEDAKRQALGRVLEGSNEADRSLTVLSSSATNVTLRWQQGQFIGGGTFGSVYVAINLDSNYLMAVKEIRLQDPQLIPKIAQQIRDEMGVLEVLDHPNIVSYHGIEVHRDKVYIFMEYCSGGSLASLLEHGRIEDETVIMVYALQLLEGLAYLHQAGIVHRDIKPENILLDHNGIIKYVDFGAAKIIARSGRTVAPMDGPNGGILGKDAQIANQRGKNQKTTTGTPMYMSPEVIRGDSPDLVNRQGAVDIWSLGCVVLEMATGRRPWSTLDNEWAIMYNIAQGNQPALPTQDQLSDTGIDFVRRCFECDPLRRPTAAELLQHEWIVSIRQQVVVEPPTPGSENGYSSSSSISRQSSTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD75</accession>
    <name>A0A1Q5UD75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000347">
        <property type="protein sequence ID" value="OKP10436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="18010" checksum="9605EEBAA2CCA2BA" modified="2017-04-12" version="1">MGNSRESHVGSLLSYIGLYHKIETFDKEATLNGLKKLWSAVKGRKASILHPLTVEKLKGKKKTVGLAQGFNDIYPYDTPEPPRDSSSLSGVTTWGEENDEGELRERPWVAPALTAGDDAVARLPVLVGIDPAVLQSLGGRPQRSPTRPMESPYPFGLVTILEGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDW4</accession>
    <name>A0A1Q5UDW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDW4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDW4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="322" mass="35406" checksum="6BC1BACC1948E0D4" modified="2017-04-12" version="1">MKKANRKIPKLLLPLSLGVSSIVLLHIINDDIERQLAKTFVNVGFELNILVVDPSTILGPDAKYDQAYEAVTKAFPKLTFTRLPFHSVFEYVPDMKEIIQEYAGSTFTDDESRSNEDRLTVFRAAIATATSKADLDSVLLTRLVVGYAKSLDCETVIWGDSDTRLAAKTLAGVAKGRGASLTWSVSDGMSPWGVTFDFLLRDLSKPELEQFKSVCDELSEIIVPDEPISDNVLTKNLSIDELMMRYVRTQGEKYRGVMANVSRTANKLESTTASDDALCPLCGGHVGNVKGNSGVTVANQSSDNYSSKFCYGCMRSRPEATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDY7</accession>
    <name>A0A1Q5UDY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat-containing protein 82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDY7"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="40841" checksum="DE6E538E1409BDAB" modified="2017-04-12" version="1">MAEGQQQTAVSQPTTQAAQQSQKIADVIRGYRPCKSFKNSKSESAANYTTSLDFDDQGDYVVAAGDDETIQIFDVKEGKSTKSVPSKKYGVHLARFTHHSRQVLHASTKVDHSLRLLDLHNEGYVRYFSGHTDKVTCLAMSPGSDAFISCSKDDTVTVWDLGSRNPQGKLKLATPYLVAFDPSASVIAIASQSTSSVLLYDFRNYDKAPFSTFDLAPFEEIYTPSTRGRGWTKLEFSNDGKFLMLGTDYHGHYILDAYDGTVKAFLTGKGGASGRASPVSSTGKPLGQGDACFTPDGRFVIGGNGDQQDVLVWDLNEVQDGQQNNAALQPAAKLPHRGRTALIEYNPRYNMIASADKDIVFWLPDEPPRPSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE86</accession>
    <name>A0A1Q5UE86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-alpha-acetyltransferase 35, NatC auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3605</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE86"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE86"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="340"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="762" mass="86603" checksum="35829D0C2AEBB874" modified="2017-04-12" version="1">MLPNNEVRVPPRRVLVQEKAVPRDITVEFTEAASKLRTGQLVKDETFTLFEAVGALEIMDSKMDSGYIAPGENHAQALEDNYDVRRHLTPEQVVGLMDQLLCHEMAWHMGHPLSQTLFTSIYIDKLLWPVPRTIEDARSDRVPSEYPLVGLVLRTYCLALVKACDFVHARVASEYFYEEEDFVTQLYNRNLLSTFDSSHFYRLLDQAVDWVDAQEGIEQKLRDAIRSRLLLRREFLAAVDQDLEILDTRSTDSFVLCLTYLKTLTETTSLGNALPEAFSLKLQRKLASTVPPRPIVHIKQEDALAHMKRLCQDAIDMQQMLDYRGPSNFKTAVWTLLSRKPQPSVYIRSLLQALIVSDMTILGAVSVRQFLYDDLAELVLPSSILLRANTDEVELPSDPRFRIAQIMEGFVKRFAQPYVDTVRSACLNRCRVRRTICHTVIDWDNLQMEAEELDLQLQNLSAEPALQFQGGEATFSYPLSSWAYHQKLIQLRLILQMGFELSVYAPEELPGIYWYLSHICSTHLSHLDRIRTFTVAARKRDLESSNNNGETSAHKSPAYHRSFLYLERLTTHIIAIDAFAIALHALYVLLARHQILPSAAGPDAYSSDKLRYELRMKPFIPISLPELVPFEEYQREATLEGDTDATILDRASKAITEARKAWEATLANGAFVEDISSPMKEPSIAIEEDWRRDIKDTMRACIGASIAIETVKKALLGDSPASEKVPLNLQVVIPVIGSKTQWHDWWIVPQISEKKAAKAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEW8</accession>
    <name>A0A1Q5UEW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEW8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="131" mass="14199" checksum="9BEE4FB9C3D44F99" modified="2017-04-12" version="1">MDILELPRRWPLYSEGLLLDAVDCDQRFRLPNPSLMGLVGANMAGRSGPFSDTMPNPAGVPALDGFPSLFREAGREVRESGRWGRWPDGGSVIGPEGRLGWNDRGSSSRVERCSIFEVGGADEIQGIIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG93</accession>
    <name>A0A1Q5UG93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-related protein Rac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG93"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG93"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11018" checksum="CFAB6F979E51E414" modified="2017-04-12" version="1">MATGPATQSLKCVVTGDGAVGKWFPEIEHHAPSVPIILVGTKLDLRDDRATTEALRARKMEPVSYEQALAVAKEIRAHKYLECSALTQRNLKSVFDEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH52</accession>
    <name>A0A1Q5UH52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH52"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="224" mass="26065" checksum="F78B63229CBEB070" modified="2017-04-12" version="1">MSIVHNCLIRGINSVYNQCINVTTRGTDTDKLDFANYAFQWTEMVHEHHSSEDSTIFPSMGEIAGVPGLMDVNSNEHAVFHDKIGQYADYLKGVIQGKEKLDGEKVKNLIDSFMPELHTHLGNEIDTLVDLEKYDKVDWDAWFKKEVGKMIKDLMGQYEYRINIFPLSIILHDKSFDDGVWKTFPPIPYVVGLVLRWMYMYKNQHWWRFAGCDFKGYPKELPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH63</accession>
    <name>A0A1Q5UH63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="32458" checksum="4978F7C7F3DA8622" modified="2017-04-12" version="1">MSTQLKRISLPNSRVSMFYRELSGSTPKKTILLLHGFPSSSHQYRKLIPLLATTHRVVAPDLPGFGFTEVPEGFKYSFETLTDTLEEFVDAMSLSKFSIYIFDYGAPVGLRLALRRADAIEAIISQNGNAYTEGFGDVWGPIQEFWASENSAEDRAKMADAMLTYDMTKFQYLNGTIDASSIAPESYTLDYALMERPGNKDVQLDLFMDYQSNVAIYEKFQEYFRSSQIPLLAVWGKNDVFFIPPGAEAFKKDLPQAQVKFLDAGHLASESHAEEVAEEVISFLEQLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHD9</accession>
    <name>A0A1Q5UHD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2591</name>
        <name evidence="2" type="ORF">PENSUB_4452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000390">
        <property type="protein sequence ID" value="OKP10147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000261">
        <property type="protein sequence ID" value="OKP11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHD9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="271"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="596" mass="66985" checksum="917621B76C240BE5" modified="2017-04-12" version="1" fragment="single">RVGRSADENVAKIQSEDIPRIEAWAQRTGSCFAAEKTELIHFTRKKREQLQGQVVINGKTVKPSPTAKLLGVIFDHKLRWKEHVQQAIKRATKVAIALAGLRHLRLEQMRHIYQAYVTPVVDYASTVWHNPLRDKTHLRHLSTVQRAALIRILSAFRTVATTTLEVEAHVLPTHLRLRRRAQHTIARLHTLPRKHPIWNALLRAQRRRNNIGNYARFPLAEALKTMDLQRLVELETIDPSPLAPWRDEPFTEIEVGSDRETAVERADTARSASDIVVYSDASGREGHLGAAVVALDDNLQVVESQQVQVGPTDRWSVHVAELIGIFYAISTVIKIAYQQSILDSRQRTATILCDSRSALQATQTPRNKSGQRIVHAILQAATEVQAEGVALRLQWVPGHCNNPGNDAADRLAKNAACPGKTHSFRPLLSRENARLRVNILSQWEQEWRSSSKGSHLRKIDGTLPATYTRTLYGNLPRNRAYLLTQLRTGHNWLSTYAKKFGFRDDDYCVCGAQETVTHVLVDCPLLRDIRMELRREVGDAFRSVSSLLGGSAEGKRGKPDTVSRAKTVKAVLDFAEASHRFWSRAPRGQPNNGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHF8</accession>
    <name>A0A1Q5UHF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHF8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHF8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="21209" checksum="0F21C962758041E2" modified="2017-04-12" version="1">MRELTEEEAKVLFSKLANYTGRSLNNLIAPPEGEQTERHVFRLQGSRVYYLPLRLANYATSIPRANLLSAGTIIGKFTKTMKFRLHITALSVIAPHSRYKVWIKANGEMPFLYGGNVLKAHAARWSEDCPEHSGVVVYSMNDEPLGFGVTARSTAEAKKLEPTGIVVFRQADAGEYLRESTDLSPIPTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHR0</accession>
    <name>A0A1Q5UHR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adhesion and hyphal regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHR0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="717" mass="81067" checksum="D02AB3A20629F014" modified="2017-04-12" version="1">MNLTTRSQAKSQSQAPPKVNPKPATPKQKSNSPRQSSANRKSSEIADTKAKRVRTGCLTCRERHLKCDEALGRCLNCRKSDRICRRGIRLNFIDIQTVAPPHVIARPRGAKVTFRDDSRFIASEYVGGFERYPPPQPDSPVEERRQLHHDAFNLMGHDQLASLFQSVAHSFDPSAFDLSHAAAVDLLGVQDGWHQHEPHLMPGDELLPHGTSNFARKLATKQYNPSPLSDPEQVYMLQVFVDEVGCWMDSLDSMRYVRAEVPFLRNFEIQLTNMQFTQILPLHALDEPLLLKAFVACGARHLSLVNSSFDQAKAANYYDDATQDLMIAMHDPNRDSVLCTTAALVLSIYEIMAPQQTPSANHIAGSRALIRECGWTAKTLGLGGASFWISVGMELLSSLHYNWTLSWNPDTWGVDMDMHQHPHQVQLFGKTEELWLHRIIYICAKIANFRIASHSLQSVNGSMNYANELSDVFTEWSHYDSLCQQWYENAPRSLKPLGNVPQWQTEPRSSFSRIWYVLICHFLTWPLTKLIGLHSRLNKRIAIVSQLFYHTACLLLGKAHPLQAEFHRKMQQSHAHDICGIVANTKDKGVINVSIRCLAIAAECLETEDAQKEALVIFDGIVKDTSWHAEPIQDELKQIWGWTVSQPETVDPAQMHNHQFGLDPALPIPKGPEFPPGLSNPLLDVGDFSMENHPYQEHYVAPHHHGLDHHLYGSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHU7</accession>
    <name>A0A1Q5UHU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Membrane protein C24H6.13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHU7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="49"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="223"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="434"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="824"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="771"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="102846" checksum="422EF18FD5EB675A" modified="2017-04-12" version="1">MVDQAGAWHQLSARAVRILWTSSTSIPFDEEMARNECDDPAATSSSASAFVTTLIPALISFAVMVVLFIILRRSNRRMYMPRTYIGSLKSWQRTPETPTGLWNWITAMYKLPDTYVLQHHSMDAYLLLRFLKLISGLMLVGCIVTWPILFPVNATGGGTGTQLNLLSISNISDTQYGRYYAHCFLAWIFVAIVFFTITREHLFYINLRQAYLFSPAYASRISSRTVLFTAVTEDYLSKEKILSMFGRQKVKNVWIGTDTAELEDKVKERDAAAMKLEGAETKLIVLANKARNKQLKKEGALENGNTEEEGAEQFDDESGSVAARWVQAKDRPTHRLKFLIGKKVDTINWARSEIERLNPEIEELQAKHRAHDVKLVSSVFVEFYQQSDAQAAFQSVAHNLPLHMSPRYIGLDPTQVIWANLRIKWWERIIRHSATIAFVVAMIVFWAIPTAAVGAISNIDSLTDKVPFLKFILHVPSWIRGVITGLLPVVLMSVLLALVPIILRLMAKWGGDPSLAAVEMTVQNWFFGFQVVQVFLVVTVASAATSVVTKIINDPTSAASLLANKIPQASNFYVSYIVLQGLSFSAGALLQIVGLILGKILGKFLDSTPRKMYNRWSGLAGLGWGTVYPAFTLLAVIGIIYSCIAPLVLGFATIGLYLFYFAYRYNLLYVSNATIDCQGRGFTRALQHLTVGCYLLIVCLIGLFAIGTGANRMALGPLILMIIFLIFIVLYHISMNSAMEPLLNYLPKNLEHEEEALLAADRKQIGRDESNGLPGASDFKAENTGVSNVDSSVGAVDSSDAEKGLADGPLPAGQEKAPNAIVKWLHPDKYHNYQTLRRLVPSPLETPSYAPEVEQNAYCHPAVNSQVPLLWIPRDPAGVSRQEVAHTSRVIPITDEDAWLDEKAKISWNVEKGQPPIYEEKPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ11</accession>
    <name>A0A1Q5UJ11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ11"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ11"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="36295" checksum="FF18AF270A952843" modified="2017-04-12" version="1">MPSNRAAWQDAVGIPLSIRQTPYQTNLTPTQILIKTQAWAINPADHILQDISLPFVKYPVILGEDIAGTIEALGSEASAHFQIHDRVLAFAQGATRGSDMGGFQEYVVVDMAFTCGIPGGMSFAEASVFPLGFTTAAHALFNSKTLALPGPEVDVVPGSMGKRVLVWGGASSVGGNAIQLARAAGLEVLTTASKKNFEFVGKLGASMVFDYTSETVVAGIVSELDNSGVPCVGIFQAAGHTDSLGPCFEIAQRVKGDIFVITTSPLQEGVVPEGVRAKMLLGDSHDDILVMWKEFLPKALKEGKYIVAPEPLVVGTRGLEGIQLGYDILRKGVSARKVVVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ50</accession>
    <name>A0A1Q5UJ50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">PENSUB_1825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ50"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="340"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="796"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="796"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1084" mass="124096" checksum="55C5DF85893AF8F5" modified="2017-04-12" version="1">MPPPPHIKPENVLKRAQELIAVGQAPAALTVLHEHVTSKRTRSSPIASLEPVMLLFVELCVDLRKGKSAKDGLYQYKNIAQNTNVGTIEVVLKKFIELAEQKVTEAQAKADEIQSSLESGPSSSTNVEDLEAIETPETILLATVSGEQSRDRTDRAVVTPWLKFLWETYRTVLEILKNNARLEIMYQATALQAFQFCLKYTRKTEFRRLCELLRNHVQNAAKYSTQMHAINLSDADTLQRHLDTRFQQLNVAVELELWQEAFRSIEDIHTLLNLSKRPAKNVMMANYYEKLARIFLVSENYLFHAAAWNRYYNLLRLSTIALATGSSTKKENPSVTEADMTKAASFVLLSALSIPVISTTRSRGALVDVDEARKNKNTRLTNLLGMAQPPSRQVLFRDALNKGLLKRVRPEIRDLYNILEVDFHPLSICKKITPILTKIGADPEMEKYVVPLQQVILTRLFQQLSQVYESVELKFVYELAQFPDPFQITPAMIEKFIMNGCKKGDLAIRVDHISGVLTFDSDVFSSSKAMHAGSAAGSAESEIGVQRLQHTPAEIARFQLARLAKTLHVTCMYVDPSYNEVRQQAKQTAQARALAGAAQEHEETLARRVIIDKKKEAATDALNRKQREEETRKRIRTQQLQEAEKQRLADEQRERELKRVKDEQDRIRAEELKKQLEELKTGVKGLDISEFDPEELDANRLRAIKLAHLEKEKNELNDRVRTTAKRIDHLERALRREEAKHVPADYEAQKKHDLELYEAQKAETLKEAKQKHAEAVALKHRLGRLVPQFSSFRKELSEKRHEEFEKRRKAAEREFEAKKKQRVKEVQERRRREKQEREEEERRLKEEEERAAREEEERVAREEERRRALAEEKSKREEERAKLDEIAQKQKQREEEAEARRSARKTGGGFVPEPTAERTAPRLSLASRPAVAAAGGGGGGWRERLAAKEASGGAAPEPAAAREEPAPLRKGGYVPPHLRGAASGSAPPAREDGPAERSDRFERPERTERFERPERAERSDRFERPERTERFERPERAERTDRFVPRHLRDPTSATPEAPPADKPEESKPSTGGKWVPRWKQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJC9</accession>
    <name>A0A1Q5UJC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1905</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJC9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJC9"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF9">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="872"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137183" checksum="30E0B4CE65BA6EB1" modified="2017-04-12" version="1">MPSRPGRDPPLPPLPPILSPGITAPPSNLPRAPPRAPASEITRKRLPERQNAPTMAAMNGSAPTSPRRGHHRSISHPFPFPGLGKRRDKGKANMWESDSDSDEVTFPMDTVDGSLRKDSKGGGDLAETKCQTCSSTVRWPRNLTTFRCSACLTVTDLEPEPSTESQTYGNPDAKDRTRGWRLKKQPFDDRPLPPLPPSARPPEQKPEMPLSARYMSDLIDRCLSMYFDGLLNGSRSSSGPDDERNGRARPPQQEGIPSTTRGPGGHLSAPRDPRDPRSRSTSGSGERLGVPNNKSTFLTPHVAQWAGKVTQVRTRANSDLQSSPKTNRHPQDRPVHHSDLENKDRESPHRVFEQLENYLIAALKGIDVLNTSFSTHQPSIRSASSGNPPRMKIDPNTLMEPTLNAAVFEPDAKTLLLGDLAENSSWWMTEWAQAEGQMPSSAKEKGSQDSRLASSRSPRINWAEVARWYQLLLTAGSSWAERWVAKRPEYPRSDAEAARQKRWESADLAQLEREIIDSRLHLQRTFMKAVENLLKRPRRLIKKPDDTRWLFILLANPLLSSPNAYLPPRPVQASHPDSRRPSYPSDGPRPTTREDKSSNKDHNRQGGSNRHHGIAKRIFGLMSNAPNECHHYFVSWFSRFSPGQFERIVELAGGFVTYRLTRQHGRKRSEIPKDGDELIPSFASAAGNTPAELHAAINNRRSPQKKSEKKKEAPMVYVEDWQIKAGSRVLSLLFIANTDGSRKSAVSLRDLRSQRHPNSAGQSGRRDNYMVPISAFYNTLLDYSDLIADFDVWESKSGKFSFCQYPFLLSIWAKIRIMEHDTRRQMEVKAREAFFSSILTQRAVSQYLVLKVRRECLVEDSMRAVGESVGAGSEEIKKGLRIEFVGEEGVDAGGLRKEWFLLLVREVFDPHHGLFVYDDDSQYCYFNPYCFESSEQFYLIGALLGLAIYNSTILDVDLPPFAFRKLLAAAPQNTGSHPPNPHTSKFKCTLDDLAEFRPALAKGLRGLLEFEGDVAETFCYDFVAQVDRYGEVVTVPLCTGGEKRAVTNSNRREFVDLYVRYLLDTAVTRQFEPFKRGFFTVCGCNALALFRSEEIELLVRGSDEPLDVTSLRAVATYDNWSNQRPEAIAVVQWFWDFFERAQPQAQRKILSFVTGSDRIPAMGATSLSIRLACLGDDCSRYPIARTCFNTLGLYRYSSREKLEKLLWDAVVNSEGFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJV1</accession>
    <name>A0A1Q5UJV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJV1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="70" mass="7644" checksum="8A60BAFC2F2CE07C" modified="2017-04-12" version="1">MGHLELIPWHNGPKKDERAKIQHRLNRGVERIMSCLDFGMVQAIPVQGTSSNKTSEGLVGSKAATSANDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM31</accession>
    <name>A0A1Q5UM31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM31"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="13197" checksum="10DEDF2D4204C9F0" modified="2017-04-12" version="1">MTGETLPQGEVIGIVIGAIVLFSIISIVPIMIMWYHRRRAAARTTNEIHDLTLSMQQPSVEQWLEGQNSPRDIEQYSREIWYVISFVSSFCTVPQIHPRIQPTLPTAWLGSGARMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMI0</accession>
    <name>A0A1Q5UMI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293419" evidence="2">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="4">
        <location>
            <begin position="108"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Tail specific protease" evidence="3">
        <location>
            <begin position="290"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="656" mass="71134" checksum="1D99A113F5349A85" modified="2017-04-12" version="1">MHLKAALLAPVALAAVAGARKNVRDVEPCAQISKLVADANDNHNPPSGYSMPSTDLLGGIDAILEKVNRNGYSSQFEMDLEVSDLIRSAYDGHLAFQLCSQSIFNYEIDIPLVSISTNGLQLPEVYTLSDAKLQQSGAKDVSPLLSINGTDAAEFLSSYASGQSLQDRDAQYNRVFPALARSVTGTSIDQNGIWARTADWSDGSQMILKYGNGTTQPVEKVAVPKERLFSYKNGTSLYKINCIPRGLPTAENSSPTAEEASSMPGLPDTQWHNSANSIGGYFSNLTGLEDTGIIFLPTFSSSPREVAQVVIDFLNNATSAGKKNILIDVPANPGGYLSIGLDLFRIFFPDAFPYTATRYRAHDAAKYLTKAYSRSDTQDSSNTFAYKEMVAPDQETGFSSWEDLYGPHEVLGSSSSSLLANFNYTATSSQTYPINGYGPIALNPEKSLFPAANIAIITDGDCVSTCAFFVKLMKRQGVRTITFGGRPTESPMQGVGGVKGGQSLGINYINGYIQQANQLIQKSAGSSSPLLTTEEWKKFNDSSPGTETSFAWSGSVNLRNEYDPDDDQTPLQFVYEAAECRRFYTIDNYLQRETVWQDAAASMFGNGGCVKGSTHGKGDGKVPSREVIGSSTRPRGLRSEHERLSEQTDRSPKWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNH8</accession>
    <name>A0A1Q5UNH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNH8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="58"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="532" mass="58452" checksum="DF7C1CB4855B1420" modified="2017-04-12" version="1">MSSKGTSVLRERNAATKERSQAAAMPQIAQMGWLEKKIKPTKISARYPVKGTPLLYATCAFGSLGDALFGYNSGIMSGLLVNPVFVSRFFKNFGGADGSTSSVDPSITGISVACLQASAAVGALIAGRLGDMVGRKKCVRIGAFIYFFSAFIQMFAPGFATFVAGRTIQGLGVGFLSMTVPIIQTEIAAPHRRGLMVGIEYTFLIAGYMLSCWVDYGFNFMLPSEMSWRGPFIIQIILSFILLAMSFFLPETPRWLAINGFMNESLQTIADLHSNGNTEDEQVQKVFYEIQEAVIYESNLGKSTWMEMFTRYRKRTIVGITVQMFAQINGINIISFYLPSTLASAGFDNRKSLLFTAANALPYTAATIVTWWLADRWGRKPLLILGGIVCAFTEAGFDVQVKANGQYAFVMLYNIVYGFTWGPMPWLLPAEIFPLRGRSKGMALATTSNWIFNFVIGMVSPDAFAGIHGYFYLVIGGFCLCSAALVHFYYVETANHTLEEIAVAFGDRAFADQDTEVMEIADAKSETGESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP48</accession>
    <name>A0A1Q5UP48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP48"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP48"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="500" mass="56351" checksum="2600DBDE5616CD8F" modified="2017-04-12" version="1">MRNTICHLPNGLSFTVTPVFGGVTFKSNDSLSHSSNSTFPPGWTIIIHSEKSPGKQPPAEERGRTGSENGRPTPSSSDSDNFTRFTTPTLNRDCLYISYIVNPPSSDYKPVMSPTRQIAMMLWATLWWYFHEPQPDLHVETAASSSTPHDGRPQGEWRVNIRREGIFKGRNLLQKLERMGLIASEDSSVGLQPMETRDSGSWSNIFVSRRSFWQIDPRLFLFTLTPRGTPPSPSLTPFQSRHASPVRDGLSSPSVLTPSEVLFHTSNIGTYNSTGPFTSASHLPTYYPPAPTQYTFTNGVRHPVRSKPPHQGEVFYVRHIPSLAQFLSFRVPFLPMTKPGAPKGPNTSSRPSTPTTTVSSSVTSVEQHLCTSAPSDLEMLHRWMNDPRVEAMWKEGGEREVQEKFLMKNLASRHSFPVIGCWDGKPFGYFEIYWVKEDPLGRLVNRVENYDRGIHVLVGEQEFRGPHRVAVWLSALVHHCFLSDMRTEAVYLEPRVDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPD1</accession>
    <name>A0A1Q5UPD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_14100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPD1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="670"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1070"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1143" mass="126875" checksum="E92D01BA6E7F7515" modified="2017-04-12" version="1">MAKGKGKRSSGANETLADAGVSVSQPESAPEMQMPQIDEGAFAGLRQKIEQRLKDQSSGKGKSKKNDKPNASAQKIPATNDKQATPKADKKREGSAQGKKRDRNGDVIARDEKKGGKNKQDRLAAAGVKKDNSNDTLRQEILALGGTEEDLELLADVDSESEVEGTSTKSKVKGGDDDLRKELSKMLEAAGHVVPEDLAEDEVEEEGEEVEEEAEAEDDDLEEEEAQDEDSEGDIEETSEPEDDVSEAFDIEEAPPAPKEIKKKEPEVVIPKEFAKLAILPRSDWYAIPLPPVGSAKQMNALPRHLIDRIHELANSLLQAENDEYAKAQSASASSSHKFYTTIMASGTLSDKISALTLAVQESPLHNTKSLETLIGLGGKRSRAQAVEVLRSLKDMFAQGTLLPADRRLKSFANQPGLVAAFQGAGGRWTERDPLPGGLQKSHLIVWAFEDFLKEQYFAILKILEVWCNDEIEFSRSRAVSYVYELLKEKPEQEANLLRLLVNKLGDPGKKIASRASYLLLQLEQTHPMMKPLIIKAVEELLFRPGQSQHAKYYAIITLNQTVLSLKEEKVAMQLLDIYFGMFVSLLKPAQPGKPGPQGKPQGKKGPKGKGRNQPAKGEAQDDEMREKLTSGVLTGVNRAWPFTDADSDRLSKHIDTLFRITHSSNFNTSIQALMLIQQITGSTQVASDRFYRTLYESLLDPRVATSSKQSLYLNLLFKALKNDLNVRRVKAFVKRIVQVLGMHQPAFICGVFYLVRELEKTFTGLQSLFDQPEDNESDGEEVFRDVPDEDDEELAPAPVETKPKQNNGYDPRKRDPEHSNADKTCLWELLPYISHFHPSVSVNASRLLDHEVMSGKPDMTIHTLTHFLDRFVYRTPKANATSRGTSIMQPLAGGEASDRLVDAGKSASQGQPLNSENFWKKKADEVAAEDVFFHEYFNRVNKDKTKAKKGKGDEDATERDEDAAGLSDNESEIWKALVDSRPELEADDDDDDDLDMDDLDSEFDEDEDEEDEEAAGSDDEVIFNDESDVPSDEDMDEASDFGMEEEVAPPVSKKAAKKETKKAAKVEKEEDSDDFDMDVSDDEAFFNSDDDLPSDMELGGVELEPKAEASDNKKKRRKLKHLPTFASADDYAALLADEDEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPG7</accession>
    <name>A0A1Q5UPG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATPase complex subunit ATP10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPG7"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="356" mass="40537" checksum="DA8FE7765D6C0F0E" modified="2017-04-12" version="1">MWKSLLPTYMLSELPLLRSGRCLSCQFRSNAALSHLRAKTSAIRHYASTTGAKESKLGNSTSEATITSPPRREPQPVRRGTQFQQNPDMKPQPGDADFKPPMLDRPIGTNTPPMAGQNTGVDKRSLKQRRDEFVDYDRHLERRKELTRQVAKPYFREWSNLRFLEGKTFLSNPRLFKGDKALYFPNMSGVTLAEPKDKQHTTSTLYGKISVVKLFSSVWAETQVGTFTGPTQNPRLAETLAKNPQFAQMVDINLEENRMKAALVKMFMWSMRRKLPEQQHSRYFLVQKGFTETLKEAVGMMNSKVGYVYLVDSECRIRWAGSGNAEPAEMETLNSGLQKLIAERKAIYEAEMAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQC1</accession>
    <name>A0A1Q5UQC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">37S ribosomal protein S22, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQC1"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="742"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="769"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="838" mass="93792" checksum="9C37309C2E616577" modified="2017-04-12" version="1">MLSGPSTARASGPHARHLLWPTVSRSGGLRPVCGATGSISSRRNRSNTSRRSISTTPIHPRYSTHLPKTVSSQWLFGTRQSSTAAAPSDPPSNTDSIEAINVLIDRINENDDDMAKLMEELELIEGDEVLEELPDPLDGQEYTPEAWVEMVRQQFGDAIPDGVLNDEELQLFTRLYGEPIIQEIVEEVPAEEDEKEPDRLLREDHEGRWEEIEYEQNAEAEDDIPVVYDMEAGAEEVETIAMRRTREVAEQLGGEIMLEQFENEAVPDSAPRAHPLTREGKFTTDPSTIHLPKKTVTGPISIILSEFSNKHIADTARRLFGGPGLPHSTTTPPPRAQLPQLPIPLHAGQHHMAEMEANAYIAVLYPGIYASTLSVLVEVRKRLGTDWIRQLISQEGGPNVLDASGGGAGILAWRDIVRAEYELMVPDHPEGAPIPYGRSTVLTGSETLRLRASAMLDNTSFLPRLPDYIHVREKPTLDDTRVVQKRKQYDIIIAPHTLLGFEEEYQRKEHVQNLWALLNPNGGVLILLEKGRQKGFEAIAGAREMLLKRYIASPGSTEYEKTFDSRGETTTIPKEPGMIIAPCTNHSTCPMHNPAGPTKGRRDYCHFEQRYIRPAFLQRIMGAKDRNHEDVKYSYLAVQRGVDMRQERGIGQGAEATDAAFEGFEHIDESDGSAPHPLSLPRAVYPPLKRRGHVIFDLCTPAGKIERWTVPRSYSRQAYRDARKSNWGDLWALGAKTRIPRKLNLGDKHGEGKKERLARRAAAKAESREADEEGDFDELDPEEDEAGDEIMEDGDDRSGLPRTPARKRGQNIPSWKKHADKKKLRQAVKRRDAAEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQN7</accession>
    <name>A0A1Q5UQN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulatory protein cys-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQN7"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="277" mass="30537" checksum="AED7FFDFBFBD9E7A" modified="2017-04-12" version="1">MPEELPLPPPGPPFDKIENFNFLLSRTDPAAKAARHYSFDADTGLVPFTNVNMDYDQTEGMGGLSVSSYDSIDDDRGSLDLRGYPYHGPTGDKGINYSIPDHIMPYSTHSIYPPVPFAPDDLGHAPGAMTPSDVSSSISPPNGQMGNTKYSTSISGDRIAAALNQEEGVRVAAEEDRRRRNTAASARFRMKKKQREQVLERTVRETTEKNASLEARVAQLEMENRWLKNLLTEKHEATPSRMPPPPQDSTPLESKASSTRSGQKHIQPKKKGVGTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR66</accession>
    <name>A0A1Q5UR66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000037">
        <property type="protein sequence ID" value="OKP14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR66"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF58">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="239"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="603" mass="67065" checksum="CC4E1E49442008C2" modified="2017-04-12" version="1">MLTFSHLNADAFENPKKNNGRKRPRVRETVAYNHYRKSKVRCDRKAPYKPCQDRGLDAQCAYSRSKSPAVTESVRPLVSSRSTEVDQLVLQQPAPRSSDSEIGEIHNPPLVLPHNQSTVSYANSAFKGSDFKTRLIGGTHWMAACSDLPVIGAMLEKTVGFQQTWRTFAEVKSLLRVANSVPAGVNGDSRKLLNLLPNRSTCEKWIKRFYETYGRIYHIIDQNCLTTELEEILIVSVDANEVHILKMLLVIAIAMQTDKSERLRGRLILQEAESCIHTSTQFQKPCIGVVQALLLLIIMKTITASDTDSIYNLMGVMGLTTQIALSMGLHRDPALFPGVTPYFAEVRKRLWAWVPSHISQRGDLYEAWDNSVSILYQSQEVLHSNSEPSNVAYPLLWTDIARAALTACLVVGRLRSINLGTTVSNGPPPTLVMFQQLLLKSLESLSQTIAGRYRLGPVAAKTRLVLAVATTVTSNLISEFGDSQQDSKFLQVGIKAAEEVVTEMGRSLKREQQDSAFDLLGFDTAKTPAPISASTFLAANWMDHEQLPDPLMQTLFPSEREFYPGSGSLSQSMQSDLCLQYPVAPFESTATIRSSPNILWEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URA1</accession>
    <name>A0A1Q5URA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URA1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URA1"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="301" mass="33142" checksum="4D20D4854373C552" modified="2017-04-12" version="1">MASQPGTHQSKPKRRGRPRPLPPDVNARNLALEKERREDMKKDLLELARLVPALAPVRRLSKTIIVKEGLQHFKKQRAMCLSAAEDMRDLVAENHRLIAELNELRFLTGERNTTPPLEPKPLSEAMIELMNVPNEVCGTFPAGFGDNWACESQCQDVLVSQSSDAVMDHAVYCSPAEDISLAVAVEPLIQGPILDEHEITAASIPLTQYSLSTETLFQTSLNGSISPHTTVDLLHTLSHEELTPDMTQLECYVPFDNYQFPPLSLDTTPIDISTAWWTQGTGMAESAQFTLGGNTGTVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URB2</accession>
    <name>A0A1Q5URB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein ASI3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URB2"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22696:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="964" mass="106625" checksum="FE522FB72A75B77D" modified="2017-04-12" version="1">MSGVFGTASMPSTSAASLANNINNTVSATSVSSLLPSPRDLFTLPFRALNQAETFAFSTVPRHIARLTGLNDISVSFWSGGPHAIGETGLRGDAMAAANTAGEGVAQAVGYGDSWYVAELTQTMRKVGGFFAYLTSIWSFACLVEALVLNRITIYASTRRHLRLGWERRLALRIIPILLFVTQIMSLLRGIRCQSSPAFSEMRYGKPGKPLIFDYASGGGALYSMTSRLMAWESDAQACGAVKMGRAWGSSDVPYGSFSLLWPVFLLLCLSHFIETLSCALQGRPVMTETGMSIFEHSLAFAEAESMISKSIGLGIFGLAKQSPLAEGSSGESSGSALQLLTRSQVLERMNVTPELLLIVLISCCNSLSSHILDVFGKQSRYRLYNTAFWGLCFMAAMCWGLESGPPLSPETGVLKFPTVCIIGFIPHLFVLLGIVTCLAIYVLALAITAFSLPVEDGQSVSIRERFVLAHENMQGSNQIRSIRLNGHEDFYTTLLRVGYVALTAASEAVFLNEGKAVIARQMTWLERDRLAEIEASRQRNSSYRNLPNQFDGGPFEAVGFGTFDLPEQATVWESGYNREKKIEKPKNGSRQVRPQAELGGVGAVRASVRLYHCISFFRAIGLLISRWIAYGFSRILDRLGINARPLWLKRLSGTHKDKAVPKKSTPSGPVDFWVLTDDGELELPEDHEFDVELEMQKQDQSYPQNWDTADERRLDEKLYSWWKVGGSWGNQDHTPDYNPPADDDDTTSVVSMSTCASESEWEDDPSDGRRTPTQTNPYPQFSRESTPALDPLLDMSTFARLLDPRDRESQEEARILAAHLSPSRDSNRIMTRSQYRQQVEKDRSRVLLSSRLHHHAAASQSSSDKRKPSADEETEMLEQLILSRRSEMSSSSDPNTWENGATGLGPNGPPCVVCQTNPRSIITWPCRCLCICEDCRVSLAMNNFGSCVTCRQEVGGFMRLWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URK5</accession>
    <name>A0A1Q5URK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein sed5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP15113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="341" mass="37332" checksum="3D4CB713086A9672" modified="2017-04-12" version="1">MTGPSIQDRTSEFSAILGHAQKRLGGSKVGTQRQALLTDAQRRQANGSPSGAQDRKAGRSEFARRARDIGKGITGTTAKLQRLAELAKRKTLFDDRPVEISELTYVIKQDLAALNQQIASLSALTQAQHPKSSRSKTDQEGEHNDNVVVMLQGKLADVGSSFKDVLEVRTKNIQASRTRTENFVSSVSSKSQSALDSQRSDSPLYNTSGRRTPQPGYQGNSSDLLTLDPSNPSPLGQSMQSDQQLLVMEEAQSSNSYVQARGEAIEAIERTISELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVQGAQRELMKYWTRVSGNRWLIAKMFGILMVSSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URL3</accession>
    <name>A0A1Q5URL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,2-mannosyltransferase MNN21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URL3"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF5">
        <property type="entry name" value="(MNN2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP15105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="55025" checksum="C9079169E91A0A5B" modified="2017-04-12" version="1">MSFTRVMRRGRILFALSLAALSIWYLATRDGLDQRASRVKEVQVTYSHNINEHVDFWREFQPLLLAYEPQCKPPRRLGNAPASGFKPSDPIARPELLKMSAKEVLMMKNAHSDFVKAISTDVPQLSYIPGTKGLVTTAGGSYLPVLVVSLRMLRRTGSKLPVEVFLATHDEYEENICDKVLPSLNAKCIIMTDIINAVPGAAKIEKYQLKPFAMLFSSFEEILFLDADAFPITKPESLFENEPFQSTKMVTWPDFWASSASPFYYEISSQEVVSMNSRQSTESGELLISKKTHLKTLLLCTYYNFWGPTHYYRLLSQGAAGEGDKETFITAAAALGEPFYQVSEPICAMGHRTAGGLAGSAMVQFNPIEDYKLVQKGEWRVNGSKASAPHPFFIHANFPKFNPATVFSKEHAVKPAFNDDWSYTRAWTIPEETIKAFGRDVEKQFWADILWTGCELETEFESWKNITGICSGVKKYWEAQFGSENPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URR1</accession>
    <name>A0A1Q5URR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URR1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="827" mass="93703" checksum="6E99D3FB012869CA" modified="2017-04-12" version="1">MSQSQEGISSTRATAKQERSVMEIDQAFERGNLIVIFGSMISICALKCSTARDKTGDEKMKMAKNLSWKSFIMNGFEYLETNHPEALDESEIRELQRYRECLPSRQVNIGTMLQAAAFLKSKLGEIDDLQRWLDLLFKNLYEDFIGNGPNEVLDSIKMLYDSNKRVQIITTSYDDLISRHCKASTILPSEEKKLWDFFSDSIPWKSILHTHGIWSEGSGAVLDGINYFETRAPVLQQALKSCLRGPKTLLFVGTGQGLEDPNFTSLLNWAEQETRDIHQRHYVLVADADGEQPGRGQVLEPIKYGHYSQLPLWLTELAQKSDKNYTPHQEPFIPPGLPVSDEFVDVQSETDTKDTIINDRTQYRDYYLRKNLGWKMSNERRSFPISCRSEEAKAFENTVTALEKDLSDHNIRWTSIDCIGRSEYGTADPIKSTILITVPPGHSPDYKSQWKCEWNNKKFDLNIEIMNGGIEQECFGNAKQKMDPLACGSSCGSLSQPRRTGTIGGFINLTTSLNDQEDKPVYAMSCHHVFAPDQPRVKWGNAKIRRLFDMVYELGGRSRSRHESQDKITILSNWMKVAFAFREGECLEVFKVLSRIAAERPPNPELMPELGVANVSDKFIRAAKTELDKSGDVDDNRELATIGAISVSSGLDAKPDPFDPHTKMEWEDWALAKLLPFVECRNFLDHNVLAPSSLQKDGQEVFAVRSWKEKSEWDRLKVYKRGRTTDYTVGIVHGRRRSLEAPHSAQGVATHVIVSDDPESPFSKRGDSGSWVIDSHGLLVGMIWGKSDFDDTTYFTPADYIFRYIPKRIADDGGPEGQVCKILHKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMQ8</accession>
    <name>A0A1Q5SMQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="27089" checksum="0B529137D9083709" modified="2017-04-12" version="1">MTSHKRPLTVSPEESYLDNPSDEDCSEWERITQDPAKRVAFERECIEDELTNQRRVILLQDNPSSRSHCRFWDCVPRKLNGEPNIRSAFRFNVKDLSGRYYERGVLQMEGGVAQLTSASWQISRFHNAIEDWFRYKGRTFEVKIYDRFKKAHAKWERKASTVEINHQLEAHEGSSQNCEKCGKVPDEPQRKDYFPEEPHSSLLSEVLASVIGVGNLDGVGGDSNARRLKKTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNI0</accession>
    <name>A0A1Q5SNI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO89561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="774" mass="86742" checksum="7D2A9ECBC81045C8" modified="2017-04-12" version="1" fragment="single">SIGRNSDHDRRSAGLLGYCEPNQYNLYEVHSGRTVFSRDVEFDERTPVAPLIEGETGNDLPDNAPPSLVSPELMLPPSGALPTPLPPPDKLENAPCGLVDNVPSESEPIDIPSPVNPIPHETQSTQDLGYSLFGRRRRPSRRLLESLGKVYATGTLNATATKDVDPLTFHEAVSGPNQLEWWAAIQKEYSSLLEHGTWEKVPRNEVPHGDRIIGCKWVFKTKANGIRKARLVIKGYRQKYGIDYHETFAAVSRMGSVSSIVASAVLRGWKLHQFDAVTAFLHGDVDSSIYMELAEGFEEDGYVCRLRRSLYGLKQAPWIWYQCVHRVLVAYGFTMAQSDNCVFYKPNCVVCVYVDDFLVAAAADAEIQQLQRALESKFKLNDLGTPRSFLGIQFDFHMDGSISIHQHQYIQKVLSDFCMEICQPKSTPMAPKALLNSVPDGSDLDEDTKARFGTAIGSLIYHMVGTRPDIAFALGTLSRFTSRPQSHHQAALQRLLRYVKATRFYRITYRSGQLIGYTDADFGGSVVTDGAYSTSGYVFKLAGAPVSWSSKRQGEVATSTTHAEYIGQYNAILHLQWLRTFLAETYLFRSPVTNIMADNQSAVALSRDPEFHKRTKHFNVKSYYQRAVLNKEEICLEYVPTEEQAADGLTKPLGPSPFMNDLGKISTIDQTVTNRPDLLIKCHLYHDNYGSDHRATYSEWSLRAQRKPTAKAKKSYERADWGKIGTEVLLLVGPWKEIKTRPALDEMVDKLTEATAAAVDKHTPDLRPTPYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT1</accession>
    <name>A0A1Q5SNT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO89658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="449" mass="49333" checksum="3E2A1227CF8C30B1" modified="2017-04-12" version="1">MSSAMLVYSLAGAAVLSAIITTILNGLAYAALQSLPSHTTTTGLAPVLISILTCITLLALSLLIHKDVRSDIRWSPLKTVIFYFTGVYLLISAVSIAGTIASNDLYNPLHQGNIFIARSIFWALSILTQGLYYGFLLVTLAQRKQGQDWPRSYTQELKSLSESPEPVRSPARTLCDPYPELKQFDTRRSSLRKFPRRSNRFSGGTICVESTRTKHDSFDTSSSTLSSPSPSPTTEHLPMHTQQQPQSSDPFADHNTHRLPLRNPSFKSMPSLRRENNIHLSLDSLVQPSTSTSPTASSLALDSPSGSTLTLPETYAFYAPNTKPHPNAYANPHFRGLPSSSLSLPSSPTFPPNSTREQNIHPLFRSTSPCPSPTPLPGSTVKASPSAGQTITQKTLTRMRSARELRSLRKEDSPGAGMWMGMGRAGYVRRSVTQYEKRGDLNELVEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPY6</accession>
    <name>A0A1Q5SPY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000763">
        <property type="protein sequence ID" value="OKO89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPY6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPY6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="98"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="302" mass="33459" checksum="D69ED9C082B01C4E" modified="2017-04-12" version="1">MSSSASPATATESQTAPAEKTYKIVQDFSNFGETEANRPNFDQAKPIEVTKSPYPNWKYGEGVPDNGASLVQKHHEIDPYAPDRPMINNYRLLVSGIVPRPVGFLSTVNSKGQKNLSPFSYFQVIDHDPPMFIVGFSSRPGRVKDTNRNLKETRECVINTVSENMIEAVNASSIDAPYGISEWEVSGLHEAPSTTVKPSRVEESVFNIEGKVIDIKEFTDHQKPGMSLAATVLIKATRFWVKEGTADAEYSHIDLDKLRPIGQLGGVCYGRVVSTFERPRSKWDDEVPKSELLAKLDAAKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRD9</accession>
    <name>A0A1Q5SRD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRD9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7766" checksum="828BE4CCA13EB67B" modified="2017-04-12" version="1">MSTGTLFVQDSRTGAKYEIPIRRNAIRAIDLQSIRAPANEADRADQVSRGLRVYDPGLQNTAVVESAISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRN7</accession>
    <name>A0A1Q5SRN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRN7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="553" mass="62283" checksum="50ECC8FB7DB0FF20" modified="2017-04-12" version="1">MTIQQFYLLGDDPSSSRPIEADATLDIDGLKSLIAAHFAIVEPTGVAFLSQDKAVTDIADVISATGPIAITIDGHEVRDPPGPTGLPWVGNYFEVYPDHLGNHQRLFEQFGPLIKTTNMGRTIYQTNNPELSAIVFAESDFFTKKINEAHPLYALKTPAAGVFLGDTDTPEWKVAHKFLPPALGPKAVRHYAPTMQKTVEDSFRVFDAFDQQGEAWNVYQYMLKLGSQAVGKLTLGLDFEHFNEPDTSLHEMVHLIAEVLSLNKKVTSKGDWYGRMPFGDPQRLKRARARIEQLVEESIQQAQKGGVEDLPLQDAALKASNMVDYAIRATDNKGEKLPKSSLVWALTVATGAGFTTTSSLLSWLIYGLVTYPGMQERLLQELVDHGFEENTEITADMTDQLDFLDKYIKETQRRHNPSFQPGRTAKLDLVLPGGYRLPKDSVVIPALHHIHNNPALWDNPQRFDPDRWDTDAVKSRHKAAYIPFATGQRMCIGFNFALQEIKVFLPKLIYRYKFTREGDGPIEYDPMFQLIRPNNLFVRAERRVKWPPRTETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS68</accession>
    <name>A0A1Q5SS68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO90839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="565" mass="62304" checksum="8376B6C23B7D4691" modified="2017-04-12" version="1">MSSEWRRLCLSQENLPPLLCQYTWTRQGYELYLTDLTTIWSERLSRKEILKRADDSATTIDPSEDLDQLDLLLTKIGEALRGDGGSNTTLNSGASSDSLQLNTSTELPAPLRPLKWSILLSREPAFSTTSHLILPLLRGEASLESRQRNLLDQLKQKDWVLSKLFDRFEALGADLGTVFPGVAGLRTARKGSSRSEAAKFIKGVAPFDEQSWLAESESISSSSAIVSNLIHELAGSGNGLDLDKLHPSQEKWWSGLQRRTEAVSFQEEEPKKLSQSRTKPIESKGDVDPGEETASESDVDEFEVCPKQCPSISSIRVPNLTEFQQQEVVPRQKPQETQPVISPSKPKARKKTPSPSPKAVHTNEASATESEHEPEPEPELSPPPRRKRTSTPPPSAAPVAQDTPPTEIPNKPKKGLGMIGGKKKIPEPEPERAPLPPPEPTRVQIEDHAQSTAPATKAKKPTRLGMIGGKAKTKQAPLPETPSVQQEEPLPSSPNQKTREKPPAPKHDRVSPKRESLEPSLPAKAPSAVPAPEETEAQRADRKREELKRQLEAKSKAPAKKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSA4</accession>
    <name>A0A1Q5SSA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSA4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055589">
        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="930" mass="103598" checksum="0B8A2605BE36B3B3" modified="2017-04-12" version="1">MEEEASIHRETGAFDRLPPNVIERILYAADANVFASLALLNRQWRKVSESPALYAYHLSQCPSFTWTRGATPAPSETDSLQDLKHQFLEEIRRNAFDVFLRPCRTLVRLISSSMSSSTAFPQGEVFRFSFSAYGHMVLCISSSRIVVLDVASEPVAVKYELQTRRRPLGATIQDDGSLLAVLSSTHRVQIYQLSNNEVKHFQTITLNDAPRDLIFSPMGSVLALSFEDCIEVYAVGEEVMSTERRAARCPRVDALSFSRDGTMLLGSPVDNDQGGIVTITAPFYTDIGIDVSPQELQMRMWTTQILFPETTPEFTHACLINGHEEADDSWIIGYDSALAAFRAIKVNAVNTGGVYFASPFLADELRETLPMMLPSTDTAGELVALGFQDSEVWVYGIPASLDVTPPIPEGQDANDSHFCGNHHSEGQLVPRDNRAQLEKVIQQPKKALIRGRRITDMNGITSARWVRSTASSQPRRRLVTVAPGGVRPQVLGEEDIPVDGGRILVLDFERSTTNGEETELDIEVGEAVPMTLMEPDSSLDTEVELERRRTRLQRGDTDPTSLTGLVHRPSRAPTRETRRTASQHGLSLLRRNSLSLATSPEGPARGEVVEIPYDNTLPRSQDTLHRAATAAASTRGRYDPRYRDTSGRRQIPHESDADNWMPPPPPYTRDADQPLPEDLQNTLLPSRSANAQNHANGTAQPVQRAQTARVARPTPSDRPRPQSAFLQRLGSITTNRRSGRGRRDSSTAAGEAPGLERAHPDIPQVPHIPHRHLTNHDLTNHDITAQNNHAWPARSDIRNATMPNLPVATNHLRSLQPLPTLTLHPAEQPTRQSQATLGATLLGEDYLSYSVSSPNLLHIPQPSGNALDLTEEDEEAQIPARQRSFRRRVSTEPNSLPPPANEEWRRRIEDWNEHTIRERSRKRRNKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSJ8</accession>
    <name>A0A1Q5SSJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_13146</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSJ8"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012660037" description="Crh-like protein" evidence="19">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="20">
        <location>
            <begin position="77"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="348"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO90845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="444" mass="46851" checksum="85C6322A7EE65FDC" modified="2017-04-12" version="1">MVRFVTPLLALSALSATALAATTTTCSTSSQCPEDKPCCSQYGECGTGAYCLGGCDPQSSFSIGSCAPMPVCENKSYKWDNLDNTVLNTKYLGNASAADWTYSGFPKTEDGNLLMTMPKNSVGTLFANNHYIWYGKISGKIKSSRGKGVVTAFILLSDVKDEIDYEWVGADLTAVQTNYYWQGVLDWHNSGNASVNDQDTFDNWHTYEIDWQPDQTQWIVDGEVKRTLKKSDTWNSTANRFQYPQTPSRLQMSLWPAGQASNAKGTIDWAGGEIDWNSQDIKEKGYYYATIGQVDVTCYDPPSEAVKSGSNAYIYTSNAAMEANIAITNNSTVLGSLGATGLDMTLGANSSSSASSTASDSVPTNHGGAGGMAINSTTSTGTGTGSSSGSGTSSGSSSSATGTGFSQGTDTTTTKGNGAPAQGERVLRGSLFAVLVAVVVLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSP7</accession>
    <name>A0A1Q5SSP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_13196</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSP7"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="223"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO90895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="58383" checksum="1CA85EFA5BEAE934" modified="2017-04-12" version="1">MASDLTKPVLDALSASDSPIFSNEAFPSHPSSNVKSALDRLGSRQMIEYETLEKEVIVLTSEGEEIATNGSHEAKVFAAVVAALDGLKISDLPGLVGKDNAKVGQGNAFKRGWIKKDNDKLRAVKETIVDETREQLLTVQKTKSLSDAKALADLKRRKLVSVSKDIAYKISKGPKYAREFVKEETDVTPEMLADGSWKTVHLKPYNFNAKGAITPAGTLHPLNKVRQEFRNIFFEMGFEEMPTNRYVETGFWNFDALFVPQQHPARDLQDTFYIADPLKADPPREDPLNDPHRPKAAQPASQATKDKPVDYQQYWDNVHEVHEHGKFGSIGYRYPWNADESLRLVLRTHTTSISAYVLHKLAANPRPARFFSIDRVFRNEAVDATHLAEFHQIEGVIADFGLTLGGLIGFMEVFFAKMGIHQLRFKPAYNPYTEPSMEIFGYHEGLGKWVEIGNSGMFRPEMLESMGIPKDMRVYGWGLSLERPTMIKYGVSNIRELLGHKVDLNFIETNPAVRLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUC6</accession>
    <name>A0A1Q5SUC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_13024</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUC6"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO91617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="441" mass="50153" checksum="AAE0B37F607303FB" modified="2017-04-12" version="1">MSKSRRNVRFQRRGNGERRLSMSDVSDGPSEPSSPSKNGNASHPTTIPEEKPQQSEYEKKKQTFITRTIWTFVMIAGFFVALFSGHIYIIGLVTAIQIVSFKEVIAIAYVPSKEKNLRFTKSLNWYFLATTMYFLYGESVIYYFKHILLVDKVLLPLATHHRFISFTLYVMGFVFFVGSLQKGHYRFQFTQFAWTHMALYLIVFQAHFVMNNIFEGMIWFFLPASLVITNDIFAYVCGITFGRTQLIQLSPKKTVEGFLGAWICTIIFGYFMTNLLMQYKYFICPVNDLGANVLTGLECVPNPVFVSQPYSLAVFGVDKTIYIAPMQFHILAFATFASLIAPFGGFFASGLKRTFKIKDFGESIPGHGGITDRMDCQFIMGFFAFMYYHSFIAIYKASVGDIIETVINGLTVDEQLDVVRGLSKYLYNQGAVSESVCIRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVT5</accession>
    <name>A0A1Q5SVT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nitrogen assimilation transcription factor nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVT5"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="666"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO92062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="762" mass="84996" checksum="5F20815211694F83" modified="2017-04-12" version="1">MVVEGTGMSDVPLKSALPRKSAFSCEACRKRKVKCNGASPSCSRCAARGETCVYSLAPTLSYTKQLEARVAQLEDALSKLRGQNANIEARKGSSPASVAESSSSAGRKIKIENDDTQDLAREFDGLNVETDGRISFHGPTSLFQLPSGVVSETAATTHVVQELEARKERLINSAWRERAFEQMAAMPEPFQYLLDSHWCWIQPLFNFVYRPAFTRDMKIQGPYYSDVLMNAVLSHSVRWCKAEPQIGPLLDSFDGGAQFYQRAVSGLFESLKVGYASVPTIQTLLLLSAQECGKGNRTQAWLYSGMAFRVLDDLGISIDSRKYLGAAQLSDEDIEIRNRLFWSCYFWDKIVSLYFGRAPTMQHSQVSPPRMILDDTSEIEIWTPHGVTFPDGAHYPPTQAHSTSCFIQMCGLAEILNQILIHIYDPMRQSTEAEFFDCVQEQAKNLSDWWDELPDYLKLVATDLPPYSPPSHIMTLNCLYHTVNILLHRPILCSRGLLKTRQEPYDKSHLVQCMASATSILSLFDLYRRTFGDNHVVLSQAYSIYTAASIFLLEIQALKYAAPGTLDKLKFCIFALERIKGSNPVITIALNLVYQEIQKLQIDIHFTMPAQPSNTTQQQQQQNPPPSQPHPHPTQQSQSPSVSSNPSRHVSPGIPHQHQRQQSRATMTTQPGTSGPSTSASMIPEYNTFQQPVTGFDLSHMGDMPQMPPTHLLGGMPNALMTVDDPGSYEITPEVFEAFSYAQPMSTTMTSSFEGGWTGHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVX4</accession>
    <name>A0A1Q5SVX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVX4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVX4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044395" evidence="1">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="214" mass="23956" checksum="B4245048191CF71D" modified="2017-04-12" version="1">MKTNVILLFTTLAASIMATPVQDSPDGIDDKLPESCYHASRCSMFWSGRCEAYCGNWGFSHMSDVGSQPIVYAREKLDTEPDSTYMIFMLDLNIPDSDVTTSEYYSSLIPGLAVNTTTRLHWWGGNYTVGKHGLFVNSSDAIAEYTAPRPRDSTNHTYTLYLFEQPRNYVFPKAALEGTYYSQTTDARFNFTLAPIVKEVGEPVAATYFLSNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW99</accession>
    <name>A0A1Q5SW99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12792</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW99"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW99"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012389108" description="mannan endo-1,4-beta-mannosidase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="13">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO92230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="436" mass="46993" checksum="ED1DA878AB141AF4" modified="2017-04-12" version="1">MYYSSAALLFAGLASAQVAEWGQCGGKGYTGSTTCVSPYTCQYQNDWYSQCLPATSTSSTSRTSSTTSKTTTSSTSTKTTTTVSSTTSTPVSTSTVFPSTSGLNFTIDGETSYYAGTNSYWIGFLTNNADVDLVMQHLYDSGLRILRVWGFNDVNTIPSSGTVWFQHLTAGTATINTGADGLQRLDYVVSSAEKHGIKLIINFVNNWSDYGGIAAYVSAFGGSATTWYTNTAAQAAYQTYIKTVVSRYSSSSAIFSWELANEPRCNGCDPSVIYNWVKTTSAYIKSLDSKHMVCIGDEGFGLNVDSDGSYPFQYGEGLNFTMNLAIPTIDFGTLHLYPSSWGEASTWGPTWIKAHGDACIAAGKPCLLEEYGYPSDHCSVEGPWQTAALDTKGIAADMFWQWGDTLSTGQTSDDTNTIFYGSSDFTCLVTNHVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ38</accession>
    <name>A0A1Q5SZ38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-lysine N-methyltransferase EFM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="364" mass="39757" checksum="88E9ACF418E90600" modified="2017-04-12" version="1">MISTTTDEPIHVLDLPQIYQKASGTELLKALALLALQPRTFGTSAEAIKGPSVQPAGVTRYLTQIISSPLSWLETDELREAVWDTAGARLSERSGRTAMPAMSRIFNIPTSSGEDYTLTLHEPSLTSDNLGMKTWVSSYLLSRRLHKLLESPPELVPVSSTDPSTGSSQGKKPLRALELGSGTGLVGLSFAALKGKSATVHLTDLPEIVPNLAHNAALNVELLNKSEANVTSGVLDWSVTPTPLPTAEERFDVILAADPLYSPSHPKWLVDTIAPWLSKGLDARVITEMPLRDAYLPQVQEFRQRMTDLGLAVVEEGEEIGYDDWESPDGDALAVKCWWSVWGWSEKGEMHRTSELGNCNSPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZG4</accession>
    <name>A0A1Q5SZG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="700" mass="83989" checksum="9EDFC142184C2F67" modified="2017-04-12" version="1">MATDEAMEDVQMGAKRPLIDMESLKRKKFKADDLPISATQHAAIDKLLHSFKKKGGFDSIRKQIWAEFNDGDRKTNFTNQLIALAESEIEREPAHLSRERGKAATLIEGAVDRSDVYKNVEDSIDQLASKHLQTILDSVRAIRREEIGEEAASKEEISGSKTDEDYEAFVKVKRDEREKIWREEMRKQKELEDEQKRLKEEEQRKKRELERQREEEERARRKEIDDKRRAERERMREEQRALDEQRDREREERYERRRREDRDRYRDWDRDRLLDRSPAYRSDRGLSPRSRDPKREKSTASKDPTPAPILPAVDEKSLEEAALQMLLKEGEELAAKARQKREFDFEEAEAIENGLKPPSTSAPAKNSTASTRAPSQSRNSRRADSTIGRSDRTRNPTRDRSRSRSRSRRRHTSRYDPDRRRDRSRDGSVRSRDRDMEDRRGYRDFRDFRDERSYRPARRSRSRSAGREGRDRDRDRERERERDRSADRDRPRDRDRDRDRKRSRSRERDHDRHRPNRSRDRSRDRDRGGDDYRPRRARSPSRRRSRSRSRHRPRSRDRPRSRSRSAAPRRRSRSKSNMRRRSRSRRRSPPRRASPGSLDIDRYVPVTSTRSRSPRRRVRSQERDRDRGMGDIDRYIPGSERAKDSTGNHGEAEAAPPVESAKDTDDRRTRRRSRSRRRSRSRRRSPSWRRSRSRRRSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZH4</accession>
    <name>A0A1Q5SZH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZH4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZH4"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO93340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="424" mass="46717" checksum="CB23C0877E22DED2" modified="2017-04-12" version="1">MARKKIIIDTDPGIDDILALLLALSAQPEEVDLLLISLTFGNIEVKSCLRNVVSMFHILEREIQWRRQNGRPEGFGAMRASRPVVAVGAEDPLEDQKMLADYFHGTDGLGGIHASHPHLTPSQTWKHLFDPAIDHQGIEAVKTGADPEDHSFIPSKIPAHKEILRVLRENEPDSVTLVAVGPLTNLALASAEDPETFLRVKEVVVMGGAVNEPGNVTPVGEFNAYADAFAAARVFALTSPNPNSTLPLTTSSMFVPYPAKLSRQLTLRLFPLDITLRHNLSRGEFRTAVAPLVEAGSPLAEWVSAFMGHTFRTLERLHPGHVGDDAELSLHDPVCVWYALTSEDPTWAPTATSPEDIRIETTGQWTRGMCVVDRRSRHPVEGDEESSSDHGLWLSQRAGNRIYRMDVSPVEKTFGTILIQKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T053</accession>
    <name>A0A1Q5T053_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Membrane protein C6F6.13c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T053"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="120295" checksum="CAA0D1D851AAB97A" modified="2017-04-12" version="1">MPAEGVTVGATSDQTASSTPALSTTPQPNVTGATSSNDAGNEKEGINVQEGTGSKSTSDTKAEESKDAPEELDDFGLPIRPRSRPDLSETDEPEDKAASSTETQDVKEKVVEVNQEASKSKSEQETETVEKESDKESAQDDKKADSKEHDAASNEEPHDETFAPPPPYRKSISKSKDTQPSEWSHQRMTQPQNDVEESEEEEDEWKAMPALGEMDYYDDYGRLIARGDKEEDDEAVYSGLGGAGKGYTRVQLDEDAQSATSMDEDTSYLFREAAGNSAGFVGEELRDTVSQLQATKDLLNETQKIAYVGVVRLTIHEMNLELGKLPTTKASRKVILKAQDAQRKWGQTMMGRLYMHMDISPAEQIMIEQLAEHGVQPGDLVRPLMQNARVKNPMAEDDPKTSISSISSPTLGNGPRSRVSTETETSDLGSPPPYEAHANDEDVPEVHTPSQLPTSAKIDIDLRWTVLCDLFLLLIADSAYDSRSRTLLERVGASMDVTWLQISRFEKRVTDALEMQEEAEKETWDESDHMEKRRKANLKQKYMIMGLATVGGGLVIGLSAGLLAPVIGAGLAAGLTTVGLSGTSAFLGGVGGTALIASSATLGGSAIGMKASHRRMGAVQTFEYRPLHNNKKLNLIVTVSGWMTGKVDDVRLPYSTVDPIMGDIYSVLWEPEMLRSMGDTINILATEALTQGLQQVLGSTILMALMASLQLPLVLTKLAYLIDNPWNVSLARANAAGLVLADSLQDRNLGNRPVTLMGFSLGARVIFSCLKELAAKGAHGLIQNVYLFGSPVVASKDEYLKARSVVSGRFVNGYSKNDWILGYLFRATSGGIMRVSGLAPIEGIPGLENVDLTETVNGHMDYRAAMPRILRQVGWEVLEDEFAEIEDPDPDNHAERQRELIREIDEARRNAELKPEKKRFGLFKRGKMAEKKTWETYDVDRNSSPHNPAEPNSAPGSILFDIEAIRAELASEAIEVKQLESTLPPMKLDLNRPPEQACTQPVTPIERSQTPKAPEVPALPRTASEPQLPTENHPTRATTNPVPSHKEVPIEMTFDTPSRPELQSSSIMPLGIGATALGAMAMEHNAWADGHDDGEIQMTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0F4</accession>
    <name>A0A1Q5T0F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional regulator WAR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0F4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0F4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="775" mass="85253" checksum="DE6C911236DF151F" modified="2017-04-12" version="1">MSDTSITPQGESSTASLPTQQLNRSCESCRSLKVRCLPNPSTPNQCQRCAKGKKACVFVAPQRRRPRKRTDSRVAQLEKEMRMMRSLLKDRIREESEPESPEGSEGSPDESVEMDFHDHLGPIPEAPASATGSSRYMDYSPEFINTAHPGMAGSGPLSAPPSMSGLHMNFSPDTNRTPPEDVVDRGIISLEDAEQLVAFFIHELASFFPLVVLPSSTTAAQLRQTKPILFLSVISAAAISIDAGLAGVLNREMVRLYAERFFIEGEKSLELVQALLIMIIFYYPPGSPLKLQFYQYTHIASTMALEIGLATKRRVSKKKSDRKNRHEPYDELLAEQARAVLGCYHLGSTVAMKTRRPNLLQFNDWMNECVQQLERSPHRTDQHLAVWFELQRITDEAMSSFGLDDTSASSPLTESRVQAVLRWFDKRMEGWRKTTPTDMLTVPMILEYRSAVLAMYELGVGEGYRDPDAIKKRYFTLPTLDEDGNQPLGPQMSAIRIDINVKWMNAAHELLDAVLTCSVDTMRRMPNLTYTRFGMAMTSLLKIHFSVRTGALGEVVTPETVNVGYYLDAMASKLGEASGGGKYKIPSRWYQVVAIKGRDWHDRLEKRYTGGVGAGAGEVGSGSGMVSESSSTDTKPITSTGQLPGSQGQAAHMDHPANPSAVDSFTVQPGLSHMPPGMENMRDGYVAMSGAGMWPMDGHSHGGHGHGHGHGPFFQSMPGGYQTSHAPGTTVPPQFGYDPQRMPPQGGGQMPGTGMELDGWLPDGSIFGMPPLPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0J2</accession>
    <name>A0A1Q5T0J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_12068</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0J2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0J2"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15 21" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="150"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="434"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="740"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO93789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="966" mass="107482" checksum="5D172FAAC498EE0D" modified="2017-04-12" version="1">MAPVRARNPLAFTPWPVTIITTAVFLALIIPILVIHLNVPAAPRTSPEGLNLTEAWQDLQALTRGYHPYNSHENDHVRAWLLERIDAIQRSAPPSEAYQPDEEKPEVFVFDDLTSNLTFFDQRSGVYFEGTNILVYIRGFKDQKEKWWETPGKAPTGKGGVLVNAHYDSVSTGFGATDDGVGVVTCLQLVKYFLSPGHAPRRGLVVLFNNGEEDYLNGARAYSQHPMAKFAHTFLNLEGAGAGGRATLFRSTDTEVTQAYAKAKYPFGSIVSANGFELVGSQTDYIVFDGEMGLRGLDVAFMEPRARYHTDQDDARHTNIDSLWHMLSGAVATTESLVSDDTDRFDGPVRDDGNVPNGQGTNAVWFDLFGSAFAVFQLHTLFALSVTLLIVAPLTLLVTSIALSQADKMYLFRSSVHLETSDEKVPLQGLRGFFRFPFLIGIPTAVIVGFAYMLAKVNPLIIHSSTYAVWSMMVSAWIFLAWFVSRVADFARPSAFHRVYTYTWMFVFSWALLVLATVLENEHQMGGGYFSLFYFAGVFLATWISYLELFSLPRMSEYVGQLAQDSRQPSSYGSRLGTGDGHEDDEGADEEPTESTSLLRGQRTTFANYVNVPGDYVANHGVDEDEEQDPNVYGNEQAWSASMPSWTWVIQLLLTVPINITMLAPLALIAASALYQTGQDGDPTLVLYLLMALFITLIFLPILPYIHRYTYHIPIFLFLILIGTLIYNLIAFPFSDSNRMKVFFSQQVDLDRGNSTAYLAGVSPFIEDIVRGLPNAQGQAECKTHVRGGKLLQCGWPGAEPNVVPGNDVSAWDPSVDWVSYSISHSETSTRSVRFEVSGLNTRACRITMDGHPIKNFSVVGSSAPDKRFIKPSSDGMQEIRLWSRTWDGSWTVDVEFNEHHASLKGRVSCLWSDDNSPDLIPALSEARQYVPAWVAITKLTDGLVDGYREFELVQDESGSWKKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0K7</accession>
    <name>A0A1Q5T0K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ethanolamine utilization protein EutG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0K7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0K7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="203"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="43708" checksum="BABC22069BE517A3" modified="2017-04-12" version="1">MSETVRPAFSGRERPLLSYGIPFPTAAAHHVTETFNASRVYVICSGSLARNTDALDRLTAALGVGKVVGRRIGMQSHTLWSEVLEIVEEARNVKADLLLTLGAGSLTDGAKIIAFALANQVHTPSDLASLAEGPNKRPQINPPTIPIISVPTSLSAGEYSNFAGGTEDNSRRKYSFQAPLRGPQLIILDPELVETTPDSIWLSTGIRAVDHCVETLCAIVGVTPASDELAEHALGLLVPGLLRCKKDRGDREAHLQCQLGSVDAMAACTSGSVELGASHGIGHQLGPLGVGHGETSCILLPAVCKFNAKHNANRERQARVREFLIRDPVVVEVLRSHSINTENSDLGDILDAVIRELGMPRSLGDVGVGRDKLDALAEHSLHDRWCQTNPVPLKEKEQVLEILEMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1B5</accession>
    <name>A0A1Q5T1B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWM histone demethylase complex subunit phf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1B5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1B5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="228"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="417" mass="45209" checksum="B038D4E9EA30D066" modified="2017-04-12" version="1">MKSSTAAKAKSSTDLASSSVNKLKKEALRDQPLAGLPTAMEKSTDHDTRTSRTGRVIKPPTAFTPPPATVASGKRKGGSRKKEANVVCIHCSRGHSPANNAIVFCDGCNNTWHQKCHDPPIDDQVIMLKDMEWHCCKCKPAPRPAAAKKSKPVKAKKAGRILHPRLQAGPRLEVGGDSFTADERRAYLSSLSHAQLVELLVHISTQNPSVPMLPANMKDLPASQFFFKPASNGTKKPETAEHITTPGSTKRTRADEDPADSDFDTNSRKRFRTTSASAKSPPKNISPEADAGPSNPPTVSTTATPDLITPSASTHPKPGPETPSTNRSQGRRLSFVSRDTTPEDSDPDTEDDLSEDAVEDHRLYPRAGNGFSPALDPENLKILDESPESHTFSHSVYDPAKSAQEMNVPPRVWQSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T299</accession>
    <name>A0A1Q5T299_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T299"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="8984" checksum="3159E4B82D3D22E1" modified="2017-04-12" version="1">MDLKPCNSSFESGQSYALLIDRDYGLNTAGWNWKYPKVDMQFDSQTANLTVDGYAAAFPYRNSITGYGQNNLVNSDESAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Q1</accession>
    <name>A0A1Q5T2Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Q1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="8151" checksum="ABF7252F968B31E0" modified="2017-04-12" version="1">MLSNSMRATRKGAQKPDLGHIQYDDDGCERKELKSSCGTATMQCEMGLELAAAPDAKLYNFYTNLYNELSSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2T5</accession>
    <name>A0A1Q5T2T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NEDD8-specific protease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2T5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2T5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="207" mass="23425" checksum="545BBEC9D328901D" modified="2017-04-12" version="1">MPGCFRYLEHEFLAQYKTSNIVLLRPSMSFMLLQTPDPRTLRQALPDFSRTTHVFLPINDCHNVTQAEGGTHWSLLLISIVDGIAFHYDSLVYGNHDEARFVTAQFSKLLGRPLAWQHLRDSPQQDGGSDCGVFVCMNMRHLLLKRLLMASAHEKVSMSLGGRKIDPSASRKEMAKIIEGFRKEGERRRSASASPMGKKSRSPPRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T411</accession>
    <name>A0A1Q5T411_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T411"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T411"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000268">
        <property type="entry name" value="Ubiquitin-like modifier HUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO94958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="22439" checksum="6886D446FAC54982" modified="2017-04-12" version="1">MGDRDRSRSPRRRDTLDRDRPRKTGGFRWKEKRRDDESRDNDRRLDRGYRDRGDRPRSPRRDRDGDRPGDRHRDGDRDRDREPRRRDDRDAPREDREKKVEKKEKKEKKPVAPQSSEPMIVVHVNDRLGTKAAIPCLASDPIKLFKAQVAARIGREPHEIMLKRQGERPFKDQLTLEDYGVSNGVQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4S5</accession>
    <name>A0A1Q5T4S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000705">
        <property type="protein sequence ID" value="OKO95223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4S5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4S5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="241"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="47927" checksum="4D2F7C1E1F10A286" modified="2017-04-12" version="1">MAEPIGLASGLLALTTFAFQCSVSLYATFKSFQSRQKRVRDLLEELEALSAVLSSLVALIQENSHINISSLELPLLRCGNTCQEFEEVLLQCSSRSGGSRTSFRGWANLKYMGDDIDGFRNLLAGYKATINIALTDITLRQSSATAEDLREYKELIQDAKEDLEARLESIDSKLASVIGKELAPSDPDAAELRSLQVERLSTEKCLQICAQLSDHISHIHIVSDRVGASTASSGAGTSPEGVTSQGLEECKSSLAATAAKLEKHMQEVMERLLAKSKKAVSSEEESRDLERLHDEWETARQCLSICSKADDHWKEKVSVIENHGSGDALQFMVSANGKVLHGKNRATGWRSRQVGGYMSDESIQQLSRDIVTFNLSHLRPEVPNLKKNSDEPSPSQDDSVEREMSAEFRQRYGHGFKLSSGTSSEANASSPGPDGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5X7</accession>
    <name>A0A1Q5T5X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-glycosidase R617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5X7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5X7"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="20844" checksum="9DA4DF8EF9C4DB8B" modified="2017-04-12" version="1">MAVDTSNAVYFWKPEGDVGYLGQWWPSSFTWEHDGEKYTYANAEQFMMHRKALLFAGPSHPISRELQKGWKLHPRDLRDLGRKIPNFTQEVWEQNRFEIVVEGNYLKFSQNADLKQKLLETSNRELVEASPRDRIWGVGFGAKNAGANRSKWGLNLLGKALMETREKLLIEDAGKKNSSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Y3</accession>
    <name>A0A1Q5T5Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Y3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Y3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16568">
        <property type="entry name" value="RING-HC_ScPSH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15898:SF13">
        <property type="entry name" value="BIFUNCTIONAL APOPTOSIS REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="57244" checksum="72D19AC3ABF8F410" modified="2017-04-12" version="1">MAGGDGSEAEPSGVRARRSPPGRRAGPILTHSQLVNTLQGHVDDIRARLQCGICIRPLYEPFSLACGHTFCYTCLTQWFSGGRSKRTCPDCRAPVKSQPAPAYLIREIVHMFTSRAELLDKGETTHEHLTNRSAESEKLDQDKANTHPQTGGLFGGLFKPKAPALKPLVDVDDGVMRCPHCQWELEEDACGGCGWVYRPDEDRTDYTESDDDDYDDETDYDSMFDGEDPEDDEFGGIDDDDSAWGAYGAYGTPFLFAERESAAAIFGPLAHALGDHVYHPQAWGPGPGHHQVYYDDEEEEDEEEDDYDEMDSFIDDEERQNGVQYDSDHSTVVGGNVPMSRASPTRRQGRPVVNLDSSDVESSDPEEGDTGGVAFSEGWNAHPTEEGPSSSSQSQYHDTRSSPVASSLVDDEASEDEDDDSDEDEDEDGHDNDDSDDDDEEEEEPLVSRARYHQRLEVPASSDGSEVTESPSPRLMRPPRHTGSSAHNAITIADSDEEQPVGPVRRAAQRRRARFSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T641</accession>
    <name>A0A1Q5T641_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T641"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T641"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO95707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="37363" checksum="9091445C34A2673F" modified="2017-04-12" version="1">MSIPEMQWAQVAEKIGGPLVYKQIPVPKPGPDEILVKIRYSGVCHTDLHAMMGHWPIPVKMPLVGGHEGAGVVVDKGSLVNEFQIGDHAGIKWLNGSCTECEFCRQSDDPLCAQAKLSGYTVDGTFQQYAVGKATHASKIPKDVPLDAIAPVLCAGITVYKGLKESGVRPGQTVAIVGAGGGLGSLAQQYAKAMGVRVIAVDGGDEKRAMCEKLGAEAYVDFLKSKDLVADVKAATPEGLGAHAVILLAVSEKPFQQATEYVRSRGTIIAIGLPPDAFLKAPVLNTVLRMISIKGSYVGNRQDSVEAIDFFARGLIKAPFKLAPLKDLPEIFELMEKGKIAGRYVLEMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T646</accession>
    <name>A0A1Q5T646_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Regulatory protein alcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T646"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T646"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="811" mass="92420" checksum="F4538AB1E34CFE93" modified="2017-04-12" version="1">METSRRSQHHSCDPCRKGKRGCDAPKNRKENGFSSCSNCKKWKKECTFNFLSSKRVESKRDHRKAKSSAAATATATPQSREIPSLPSSHGDILDNILLSSQWYPVNAGGMITPASTTNRTSFSPPSLNQESSSIIEEIGMQSSGDEQFEFPSWNTSVTDDFWFPVTSTQQPVKPFSELSPKSLENAFDAIPHFEENSLGMNTLDFSVLDIIAPGYRDTTRQFSASKPNRRQKSKFECHFCIASNNTAADYARTTMTQNLIRIYHDSLENALSCWLTEHNCPYSDPLTDMLPYKERNEWSSSWPNRMCIRVCRLDRASSHIRGRNLSADEDKAAARALHLSIIAFASQWTQHAQKGSNLNVPAEIARDERSIRENVWNQARHALEHTTGIPSFRIIFANIIFSLTQCPLDEDEDERLGQLLENDVAPMFLEHANRQLFTFRHKLTRLQREAPSHVRELRRESMGSTLTDMSEVPRFSSTAPADPTLANDEHRTTLSLLFWLGVMFDTLSAAMYQRPLVVSDEDSQITSIIPVSELEDQVDLNGWNLPRNEMQKKKDVWGDFFLHQAEQPRWPCSYEQAASVLSEATPVKVLLYRRVTQLQTLVYRGVGPKRLEEVINETLLVYHHWNNTYQRFMLDCVANHELLPPRIQSWYVILDGHWHLATMLLADVLETVDRGKLGSDVERESRHSSNLITKLRRENAFAVGALARSSLRGKESIVRVDFHDSLTEVAFLTEPWTVVLIHSFAKAGYISVEGMDMSSEQDSLSECFRQNCEFCISALQYLGRKSDMATLVARDLSRNLNVKLSRRFYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T685</accession>
    <name>A0A1Q5T685_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T685"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T685"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048666">
        <property type="entry name" value="RedAm-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21761">
        <property type="entry name" value="RedAm-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012592442" evidence="2">
        <location>
            <begin position="18"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="NADPH-dependent reductive aminase-like C-terminal" evidence="4">
        <location>
            <begin position="159"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO95722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="285" mass="29999" checksum="25C4F969A61DECE9" modified="2017-04-12" version="1">MSSVSILGLGAMGSALAARFLEEKYKVAVWNRSPEKAGPWLDKGANLAQTAVDGINASDLIIICLLDNAAVQTTLAGALGQLQGKTIVNLTNGTPDQARKLSDQIVGHGARYVHGGIMATPSMIGSPYALILYSGSQEAFKAHEPDLLVLAKCIFLSEDTGAASLHDVALLSGMYGLFSGFLHATALVRSSTPAVKFTDLLVPWLGAMTEYTKGMAKQIDEGKYASEGSNIAMQLVAIQNIIDTSAAQQVSADFIRPMKQLMEKAVVAGHGGDDISALIDFVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y7</accession>
    <name>A0A1Q5T6Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposable element Tcb2 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11015</name>
        <name evidence="5" type="ORF">PENSUB_1821</name>
        <name evidence="4" type="ORF">PENSUB_5263</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000525">
        <property type="protein sequence ID" value="OKP09372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000204">
        <property type="protein sequence ID" value="OKP12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF119">
        <property type="entry name" value="TC1-LIKE TRANSPOSASE DDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="2">
        <location>
            <begin position="82"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="434" mass="50614" checksum="841891BF2998A418" modified="2017-04-12" version="1">MAKQSTIARRATVVALKAYTPKSAAEIAALTNLSVPSVNRIYAEAIKRGFDPHRTMVDNQYVEDKPRSGRPTKQDPSTVDIILSKVRLDRYGREKTCADIAGDLSKLGINISGTTIYRVLKNAGFRKTKPTRKPGLTKKMRAERLAWCLAHESWTLEDWKNVIFSDETSVILLHRRGGYRIWRTKDERFLRSCIRERWKGASEFMFWGCFSYDKKGPYHCWLPETAQEKRDAEKEIERLNNEIEPTLRTAWEIETGVRRLNLRQNPSGRKPTWKFTAKNGKLGRGKRGGIDWYRYQRLILLPKLLLFAQECAIERPGTLVQEDKAPAHNHHIQQRVFDAAQVQRLLWCPNSPDLNAIEPAWPWMKRRTTRKGAPKTRQEAFSAWKAAWQELPQERIQQWIERIPWHIKQIIELEGGNEYKEGREKKQQGDWEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAP0</accession>
    <name>A0A1Q5TAP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAP0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="299" mass="33005" checksum="C57D81AD0163B285" modified="2017-04-12" version="1">MFSIVTYCYLKTFAVLLRIVIALGSRIAGRPVPRPDEVRHIASRDPGRTIKIYVYRPVKPTTGPSPVLINFHGSGFLLPLHGSDVEFCQTISKNTQYTVLDVPYRLAPENPFPAALNDVEDAINYALGRSEEFNSSRISLSGFSAGGNLVLAASATLFPPNTFRALLAYYPALDLASDAATKVAPDPSGRVIPIPVARLFNRCYVPPGVDKRDPRISPKYADLERFPHRMLMITAEGDSLALEGEDLARKLEKLPGRHVVSERMAGCKHAWDKRTRAGTPQREARDRAYTLAVDMLNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBM8</accession>
    <name>A0A1Q5TBM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea active transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBM8"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="693" mass="74061" checksum="71AD50F03DA28099" modified="2017-04-12" version="1">MGNELRVLPASVGYGIVIGIGGIFALFMLSLTWLQNRYTRFSTHHAEEFNTASRSVKPGLISAGIVSSWTWSATLLTSSTFAYEYGVCGPMWYAAMGTLQILLFGLIAIKIKTNAPGAHTMPEIVLARHGKIAHLTYLYYGLATNMLVGACLVLGGAQVVEALTGMNVYAATFLIPAVVAAYVIAGGLRSTFIADYTHTVILFIAILVFGFLITATSDLVGSPGRLYDLLQEASRKMPIERNTDGSYLAFRSVGGLIFAFDLFVAGFTTVWLDQAYWQRAIASKPETSVKAYILGGIAWYGIPFGFATVMGLGCAALTGDPRFPTYPNPLSAEQVGAGLSAPATAIALLGKGGAVLMLILLFMAVTSSTSAELIAVSSLLTFDVYKTYFRPNTISTDLVRVSHWAIVVYALVLAAFCCVLNAVGISLTWVLTVLGVIVGGAALPVGMILLWKPMSTVAAIGAPWIGLLCGVIVWFITAWKRNGSISVASTGDTTNALAGNIASFGGGFIMAVVLSYAFPKKHESPDLNAITGIAASIEPPTLGPEQTPPTAEKENEKVAKPVSDDMLKSQSLPAFRNELVDYLESSTIEPMDPELARKGTRIAVVANTIFFFGAVILVPFTLFGTSYIYSKPFFTGWVVVSFIWIWTSVMICVVYPVVESMGALRSIMGGLWGDMKAVLGRRKEKVAGIRDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD79</accession>
    <name>A0A1Q5TD79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-dimethyl-L-lysine(36) demethylase</fullName>
            <ecNumber evidence="3">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD79"/>
    <dbReference type="OrthoDB" id="4494329at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="12">
        <location>
            <begin position="213"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="428"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="531" mass="58941" checksum="287693B0470637AE" modified="2017-04-12" version="1">MVSASPQDGRRRKHSEINHDYRDRMKRLKTILAILLAPAGPYDLDFPTFGSAGIQEIKTFIQGIDEHAEWALSNEERGQLAVDAAMAAGPGGQSYALMALAFLIPDLMAVPSTVIRITEFQTLQDTLATKFSRPIHYRASGSDTSPLGHRFGISPFWLYLEEHATKEINVYDYSVKNSADRTRRCTVKQAMAHWEERPRNERSALNLLDIENRSQTQYYPQALRPYDLEGILSRRDAGAIGKTDSQWKGSDQREFFLMSEKNAVSSIHVDTGAQVTWVQILAGRKIWYFPRDLTGSTRCLAHGGSLEYQLFDAGWAKVELRAGDLLIMPPSCPHAVFTPEDCLAVGGQVYTAAHLSSSLDGLRMQEAFPAISNEDVKADTYHLLSCIFTTLEKISMENRIIRESLRPAALAISTSAYLEALDVNMANSQPAPSTVGTAKSTKSTKPTHSTVDTATLQPAKRAKPARSTADTTNTEHGLSEWESSRTAQRVEQRGSAQSLIDLTARKTLVEILTEREKRYHVAIGLIDAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDA6</accession>
    <name>A0A1Q5TDA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDA6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="640" mass="70088" checksum="FDF26AF01F5B5199" modified="2017-04-12" version="1">MKDHKTPDTAAGTPRDHFRTPRRPSPQSSSKTSKSTTSKRTSSPGLSTSGRAKKRVSLPSSYRAQSTLTQIHFVAHTPHPEDDELDYIDNTGGGGDARKAAQPVSIDDDPSEEDSEYRPPLRARPAPSTLGLNDDHPKRQRESAVVQRPPLRKRQTPKQSNGRGKRKSTDKPPAKRDKTLTQMDFVRRYITIDDDDDNDVNMVYLPPAPEKDLKEAGQQSDMAETKGVKPEPPLSCIKRPRKALEAEVDLSTGEPISQSDETQSLTKLPDPQDPSKSDIPTTPQKPRRLEIPSSQSPPESPGLAIITSSQFRSATRLPQKKARLNFAKPENSIKEESPGASDIAGESADEEDTIQNQTPTHSRPIGRNSPDPTLPSSLGNILPTVSSSAEVSQKSAPTDCDPPPERAQRERTVIYETDAETDNDDLEDDIGDGLDTPTRPPSPRLGSSNEIHDGPQSPCDGSQDLPLPSAHTCADPDSEPLSEAPMSDASMFYRRVQSATQFPHEPIPTLNTQKLSELFPNEGSTQYPRQGNAHHTQQPPLLSSQTQTQTQSQATDQIEIVPESSPTRDHDEDVFQRPQPPGSMVQVESSQPVDRAHHGLGGMLSRSQLLTSSVMESIPMPNFWIGSQDSVGEPYSLPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDB0</accession>
    <name>A0A1Q5TDB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 97B3, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDB0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="545" mass="60942" checksum="7D955D34A5C7D593" modified="2017-04-12" version="1">MGIINDNLNVLYLGVAAALYLRPEYALFESRAGTMVLSFLAITSWKILYQLALYPAFFTPIKHIQTPKGRTWLTGNSETIFLETPYKRMLQWAANLPNEGLIRYYIVGNLERVVLTSPKALSELLVTKVYDFEKPQTLRQSLRRIVGDGILLAEGDEHKLQRKNLMPAFAYRHIKDLYPIFWSKSVEMAKLIQQDLEQRKASGDKDNTIVVRNWASRATLDIIGVAGMDHDFDSLRDPLNKLNRSYQQIFQSPGLGTKILFIIGMMMGNVTLLQKMPTQRNKRIDEGGEVIRDVARQMIRQKKEKMKNSNSQTGVDIISVAMHSGVMDEENLVDQLMTFLGAGHETTATAMQWAVYALCKNPDVQIKLREEIRANLPSISSEDSGAIDATTIDNLPYLHAVCNEILRFHPSVPGTIRTAVKDTSLVGKPIPKGTTLIIAPEVLNHLEELWGPDADKFNPERFMGPGKANTGGATSNYAFLTFLHGPRSCIGQGFAKAELACLLAATVGRFNMELKYPDRELELREGATVSPKDGVVAVFTPLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDR3</accession>
    <name>A0A1Q5TDR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDR3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="585" mass="60884" checksum="D5B3F0683C04EE3C" modified="2017-04-12" version="1">MSRRATPGQAAQNQQTIKSLLKLESNKICADCKRNKHPRWASWNLGIFICIRCSGIHRGMGTHISRVKSVDLDAWTDEQLQSVVRWGNGRANKYWEAKLAPGHVPSEAKIENFIRTKYEAKRWVMEGAMPDPSTLSDGDDDVVSDGTKAILPKSAPLTDQPLAVVQEKAKIERSASQRVVAPSQPPAQRQPAPIDLFGDDMISAPPRPSTTEPTPRAPPRQAPPPQQKAHKPADSLLGLDFFGSAQPSAGSRPSSTASTPAAPTGMSRPDLKQSILSLYSKPQPAPVQHARTNSFGDLASPQPPSAASNMGGLTDAFSGLSFPSTTSPPPVKPVEKPSPFAGLTNFPNTKSTPAAPRVTSPSSSASGDLFESLTSPTLSAHNTQSRNASISSGQDFGFGGFASPTTKSAKPNPPSSSLSNDLFGLSSPPPAPAASVAPSRPIVSSPQQEMSSAFNLSSPPIQPSAPAKPTVPVATAAAANVMSASMDPWGGNAWGSPDPVPEPAPAPAATHSSNMMKLPDTLTANDIGSGWGAPPKPTPTVAADEDFGGWTSAAPVSSGTTSTSNSKPAGGFGGGSDDLFSNVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE81</accession>
    <name>A0A1Q5TE81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9194</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE81"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000072">
        <property type="entry name" value="Leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000285">
        <property type="entry name" value="Leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="58"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="13">
        <location>
            <begin position="271"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="482"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="791"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="980" mass="108677" checksum="2AA03E3C24646C6A" modified="2017-04-12" version="1">MQTFHRLRLTPSFAQTRRCARPGLRSPTPLFPSNRLIRLAATVSIPRKLDLPALDKKWQTKWESTGASSRPTLETSSEPKPKSYVLSMFPYPSGTLHMGHLRVYTISDVISRYYKMRGHDVLHPMGWDAFGLPAENAAIERGVDPAAWTKQNITKMKEQLRCISASFDWDRELATCAPEFYEQTQRIFLMLYEKGLAYQAEALVNYDPVDKTVLANEQVDANGFSWRSGAKVEKLNLKQWFFRITEFKEALLKDLDSLSGGWPERVLSMQRNWLGKSHGANVTFPVTVGGDGQEVTVFTTRPDTLYGVEYLALSLDHPIVAKAAEKDAALRKFLDEASSLPADSKAGYRLNDVFASHPLRLIDNESPHVQRKLPIFVAPYVLSDYGEGAVMAVPGHDTRDMAFFKENVNPEYIPIVIEQESSENATSDSTVSAKDAKAFTQDGFLTSRCGKYQGLHSKEAAKQIVADLEKVGNAKFVESWRLRDWLISRQRYWGAPIPIIHCGNCGPVPVPAKDLPVKLPKIEGEWLKGKKGNPLESSEKWLHTNCPSCGGPAKRDTDTMDTFVDSSWYYLRFLDPANKGAPFSPSVARPVDVYIGGVEHAILHLLYARFIYKFLAQSDLFPAISHSDETPAEPFKTLLSQGMVHGKTFTEPSTGRFLLPSEVDLSSPDKPLIRGTTITPNVSFEKMSKSKYNGVDPTVCASKYGADATRAHILFSAPVSEVLEWDETKIVGVERWFGRLWKLVHDTQQTLTDASFAINAVDLETSNGHVVSLPPSLQDLSDSDADAVLATHNIISSVSSCIETNPYGLNTVISDLIKLTNALSSAPPSSPLALYLSISSLLRLLSPIAPALASESWEILHESLVKNMDPSTPVPSILSAPWPTPLLTTEQAEALSARGGQTVAVQINGKLRCAVTIPRMDSSITTPSHGKAPSQEEQDWIISRVLETAEGKLWLQEKNDWEKRRRVIVVKGGKLVNVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TER5</accession>
    <name>A0A1Q5TER5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase hel2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TER5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TER5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="527" mass="57230" checksum="9E25FD69FD183A0E" modified="2017-04-12" version="1">MADLRKHEKHGDHKPGAIDQSGFKGHPECGFCRQRFYGDDELYTHCRDKHERCHICDRRASHRQQQYYIDYHALEAHFQKDHFVCLDQECLDKKFVVFESQMDLKAHQIEAHPNGVSKDVRRDARVVDLAEFDIRSPYQPQRQRRGAGRGRDPNAEPLPVSSAQPLGRAEQAFQRQQAIQSSQSVTTRSFGGQLSRNDTQTVQAPARSAAATPNPAARARPPPTAELESLSLAASSEPLSPQDQARRLRHTAVVERASNLLHNDANKLAEFRTRVSSYRTSSIGATELIDAFFSLFDTSSSELGKLIKELADIYEDQSKRTSLLQAWNDWRAINEDYPALPGPGGLLPGMSPGTVSTGGSRVLRLKSSTAQSSRSAVGRSGAISSSSANPFPPLSAAVGSSSRRNNAATSTPWAAAAPPPSISRPTYSTPPSRASPAMGPSTARPAAGADAFPALPMAAKPNVMMPGKTRGYVRWDGSKAPAANAWGSNPSSGLASPAEPVDDFDDEPSDGKKGKKKKGKQTLFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF98</accession>
    <name>A0A1Q5TF98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligoribonuclease, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="21091" checksum="9B5A19D50A29CEE1" modified="2017-04-12" version="1">MPLARSNDPLVWIDCEMTGLDPDHDTILQICCFITDAHLNLLEPNGFDAVIHHPDSILDNMSAWCIDVHGRTGLTASVRASTTSAAEAADSLLDYIRRHVPAQRTALLAGNSVHADKAFLARGPYAKVLDYLHYRILDVSSIKEAARRWGSEELLQQVPGKREVHLARDDILESIEEMRFYRERLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF99</accession>
    <name>A0A1Q5TF99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF99"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF99"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="71346" checksum="9748C33ABB4BCC41" modified="2017-04-12" version="1">MSLEYAPYQPTTPPGVPLQVHIGSAHSRNASGSSVYSNDSSPWSTMTGSTSPTTSPTRHHHGPALLPKIRPQDIVIEPVSAGGPLRHRRVLSNTRNPPGFVPYPSRPPLQRNREDASDRLALASPISPIVTNGHGSSSALSSPVTMNPSHRRRAGGGHSRSVSTSGIDEATLNRYGYPTYRHLPKYVPTMQAQTMPNTPATPVTPITPNIVIHPSYSQRQTAKVPQPSPVQPPHPLTLRSPQYDYHQTSEAQQSPVALLSPQEDLTPPSTNLLSYLTSPTQAINLVRNVSVVPTRGMHDYFWWDIRNLRSWTSFSIPTFDSIHGLTQLLKTEISSSLVPPVSVVPGRLAPESEPALVSLIRDLYAPRVNAALAVSQGTEHLQLYAAPDMRHTGHKNHGHPHFLANYASDSERTSAGLPRGRLVGIVKSFDRWNSGMRNEAPHRRVEYLNGLAHLQRCMREHSCRYGFIITEIELVCVRAGCDTGDDVPYFGFLEIAAPIPLMTAATQPHTIHHEAPPLATPISARSFSSSSHGSSSHSRQDSPAPEGNEGSFTAPMTASMALYFLLMLSKSVPLPYQPSAHLNVGGPGALTRQRILPEPKDKWIPEPQIGERRDAKRVRGWVWPGDAWHRREGGGVPRTRGGDGKTKKWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFL3</accession>
    <name>A0A1Q5TFL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FLOWERING LOCUS D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFL3"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="55769" checksum="AB7AB470E553727E" modified="2017-04-12" version="1">MSTKPHVGIIGAGFSGLRCADILVQSGARVTILEARDRIGGRVHQEVVGSHLVDLGPNWIHGTGENPIISIADATQTVAHDPEGRNISISRDGHLLGEDVVTKAEEFMWTTIGQAFEYSKQHGDTIPPERSLYDFFQEKLEQSDFSEEEKHLCLDSCKLWGAYVGDPIERQSLKFFCLEECIDGDNFFVASTYKRILEYVSRNVLSQADIRFKQAIVSIDAPPRNDAQSRHQITVATVTGERYSFDKVVVTCPLGWLKQNAEAFSPVLPIRLLEAIHSISYGRLEKVYVTFPRAFWHTPSINTNGQHAGSTSGSNPVKNPVFAQFLNPSYAEHPENIEWNQECISLAAMPTPYNHPTLLFYTYGPCSTHIVEQIASLDPHSSEYRKVLVGFFEPFYSRLPGYDITSPDCIPTAVMATRWQKDSYAGNGSYCNFQVGLTRADEDIEVLRSGAGVGSERGLWFAGEHTAPFEALGTTTGAYLSGERAAVQVCESLGLRISLYGVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFX8</accession>
    <name>A0A1Q5TFX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="537" mass="61437" checksum="ACF330D5B8522EDA" modified="2017-04-12" version="1">MDIISEDQALLRQYQDLPKSSRQAILRGILDQLPRDGWREIKAQADVHTFQYDILGKLPLELAALVAECLPLVDIIRLRRVSQRWQQVLSSPSLCRAAARATLGKDPWALSSSEPQLDTRAPGTLTSAPTVSPDTMVTASTPNSGHDFTSYSTASFTKIVKRRHRLEQGNPYKVTTMPFPLPIEDTQNHSELDLDPRTFVTYSDSSCAWLDPKENLTTVVVLDLVNENRKKFTTDNREKLCSLQFAKPFIAAVSIRGYCHVWNIDTFEFSSFRIPSIDFLNMLISGTKVLVQFHHCVVHWCFKTRIARTMETGSVIALALHPSEDQITTVCLCAKDEKQNWSKVPIQDCQLRIEKHALDSRHEWCLLSWRYQPISVSAFPEQATYFAGILDSGGTLYSGQSNMVMYTREEIEKDFIESSRLFCLSIEPDERVVFHTFPTDVHDLTCPERGVIYAPRVSTYSSQYVIMKSKAMTDPENLSIWYDYYIHRTIEAEYTPWIMGDARFLIVFDDEQMNVGTMDEPDLEDREAVDRVNELIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGC0</accession>
    <name>A0A1Q5TGC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGC0"/>
    <dbReference type="OrthoDB" id="4366218at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="252" mass="27796" checksum="0BDD92C899A8B4A1" modified="2017-04-12" version="1">MMSSFAESDQLSPDPTQENTPSAEAMVVTRSFSNMIKAEDYDQSSPQSPVDTGGEAVDNELFVPLSGPLPTTSTADEAQNTATPNPTPPEPPKATKPTRGRKRKTPVATTESEPAKKKKAPAVKPSPAEADPLEFTEAKPDVATMMGFPLPKINHGGTRPLRVPRDLYSTPSISDMDDANAVERVFRDLLAVREVVDWESRWLGRRLWLLRKKAALEAQREDARLSKMWEQDNGSLEEDIKKLEAENGKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGF8</accession>
    <name>A0A1Q5TGF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Activator of stress genes 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGF8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGF8"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="806"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="842"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1025" mass="113334" checksum="640CF712EC391E28" modified="2017-04-12" version="1">MASGSGAHGDSEDDPAPGDYPHDDADPSQFSTQETPSSDPKLTSQSLPLQKRRRVGRACDECRRKKIKCDGKQPCTHCTVYSYECSYDQPSNRRRNPAPQYVEALEARMQKAEALLRAVLPDVNLDDPNLDVNAPEYRLPFHLKDKQPATGGVVPKPHGTSAETGPEAGDESLLETMVGNTGCLDRDDQGHWDYHGHTSGIIFVRRLRKQLGAVEPPVPRNMTAMLESPKSVSVSDSPQDASLPPTHDLPPRAVAIRLCHNALDDACSLMRFVIEPKFFASLDRIYETPPEQFGNEENSFLPLLYIVMAVGCLFSDDGAGTLDLAGYEGAIGQGFQFFKAGRQLLEITDCRDLTSLQAICFMVLFLQSSAKLSTCYSYVGIALRSALRLGLHRTVTADFNPIERELRKRIFWVIRKMDVYVSTLLGLPQMLSDDDIDQEYPMEIDGEFITAEGITQMPTDYTPLMAGCNAHTRLCNVVLKVVKYIYPVKNARYRSKSDQRYMVSHSKIREIERDLQAWMEELPPALRPGTEVSPQLERIRQLLRISYAHVQMVMYRPFLHYVSGGSQARGVDKRSYACAAACVSVSRNIVHITTGMHKRGLLNGSFWFTMYTTYFAILSLIFFVVENPDSPTAKDGVLKDAMEGKNTLAGLAKKSMAADRCSQSLTCLFKTLPEMLKSRQGSKAPINLKRRAPSNFALEPESIQKQPVQTLPTRSSTFPAQMMAQSSPTNAAASRRQKSLDTQPVNNRPPESGTQSAWLASTPELLTETMSTPEPSSATSFNTSFSNQEPSSLAWAQQFNNPNNLPDLMPMMFPSDDPFAYPTQPMSTLEDDHFKHERSGAPQSQPSFDSPSQQQGMGSNTPSDQSGTGISTPSFDAFANFSNFPMNPGSGMKSSIPNRLQQPTTQPMNHSRLHSPISQGQTPSEHLSSPDLVSIPNQNFVWQGYNFQPANVEAVNNEPTTSTMQQDTAPLNGLPDFNMGLDENALGMNMDLGISFDDLFGNNANFRPGAGAANDDWTQWMNAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THM5</accession>
    <name>A0A1Q5THM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rpb7-binding protein seb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000654">
        <property type="protein sequence ID" value="OKO99712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THM5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="250"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO99712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="408" mass="43264" checksum="2A648EC7A70878C6" modified="2017-04-12" version="1">MAKQSAVTSASPNPLATLTPSAAALHLVSSVDSSPLPPSTANPYTGVAAGAGAMVNPFATLGAVGENLAIPQPRGHSQTLSPLVAMLPQWPAAAPAMDGKAMSRQIPPLQLLSQQGISQDQWVAALQLVTIADTMGAANPAQLPGFGAIPCQGSGGGGHPDVQNRVDSARGRDRDHSRSPPAGYGCPSHLPGWDRRQLPRRLAATIGRPPHWKRLSHSPLRKDHNLPSSGPKLVEWDSSIGPGNIKVLSRTLFVSGISSEAHLRSLFNKFGIVQTCIVNIKKRHAFIKMISCQDAVRARDERESFRSGELQLRTGWGVGFGPRDCSDYQTGISVIPIERLTNADRKWLLTAKDGGTGGRPIKSGMVVEEPDIEICAGFSSKAIGRRIAASTGGCGGRPDRNGFCFRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI22</accession>
    <name>A0A1Q5TI22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial protein PET191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI22"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI22"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13222" checksum="FC884C87F3EE62CE" modified="2017-04-12" version="1">MPSSCQDIREALAQCLQESDCIMVQRHTPRECLASPLAEELPMKCQQLRKGFSECKRGMIDMRKRFRGNHPISVAKEMDEKKSSSSGQLYAGRPAYTTVKELSGDEVQMDPEKTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI80</accession>
    <name>A0A1Q5TI80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI80"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="163" mass="17243" checksum="6D43D1AC447B24FE" modified="2017-04-12" version="1">MTDVQQKDTMQEAPSPTAPKRKAPDSTPGTINFTSRNPPWTYLKLQLIPQPDSPLLQPLDPLSARTYLSSALSQFLGVTGTAIPIDILKIENKGSTSSKPNGVNKYDCVWVRVPRDDGAAVVAAISSWIGGSGSDNGAAWRVCAKGNFLGALVSGSGSDLFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM97</accession>
    <name>A0A1Q5TM97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM97"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="68"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP01334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="41294" checksum="80DF07E657808CF7" modified="2017-04-12" version="1">MSSIQAPHNTLLIPGPIEFDDAVLQSMSHYAESHVAPGFVKVFGETLTLLRKLFQSTNPSAQPFLIAGSGTLGWDLVAANLIERGENALVLNTGYFGDSFGTCLTTYGAEVTHLRAPVGERPSLGEIEAALKQKPYKLLTVTHVDTSTGVLNDIKAVTAVVRRVSPDTLVIVDGVCSVGSEEIAFDEWDLDAVVTASQKAIGCPPGLSIVYCSGRAIQRAQSRQTPPASYYASIANWLPIMQNYEACKPSYFATPPTQLVHALHTTLSQITSRPMSERIAIHTAASDKVKAAIAELGLSQVAPNPDAQAHGMTAMYLPDGLTPPDVLPGLLKRGVIFAAGLHKEIATKYIRFGHMGVSISDPNRNDIDKALAALKEALAEAKQAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B3</accession>
    <name>A0A1Q5U0B3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="6147" checksum="D1DCCC093DC79E88" modified="2017-04-12" version="1">MIALKFLSRPSTMAIGRLVVTVAVEAGKPPGSTRADIRTSTLRRKTMRMAMLIETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0R6</accession>
    <name>A0A1Q5U0R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000600">
        <property type="protein sequence ID" value="OKP06070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0R6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0R6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="45964" checksum="84553CAC9169E566" modified="2017-04-12" version="1">MAAYVRRLEPLAGSRASALVERLLDPVPTDDPNEPLNWSRLRKNINFALVCFYALIVYTIIDIGTVVYGQLHEELGFSWEELNQSFAVSTAGLAIGAIMFIPFAFKFGRRPVYLLSIVIMVGTTIWQARMRTVGDLFGFNIVSGLAGSITETICAMTIADLFFVHQRGSRTNILTIMIIAGTYLAPVAAGYSAASQGWRWIWWWSSILAGVTLFLFAFCYEETVYTPMVRGDIPDDIDGIEQDRKSKTPGADTLHLEQSNTLADIPLKSYWQRMSLFTTASGGSNALFIHIYRPFIILFTFPGVAFVALVYGSLLAWLAILLNVQAIYFTLPPYNFSSSGVGLLNIPTCIGSILGGFFGGQLSDYNIQWLARRNGGVYEPEMRLWLALPAILITPAGYFMFGFSVSQASYTNLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1A3</accession>
    <name>A0A1Q5U1A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat-containing protein slp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1A3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1A3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="325"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="370"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP06258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="647" mass="69547" checksum="DA9A8ED0CB81A21A" modified="2017-04-12" version="1">MATASVSTPVKTHHGIFSSKTAGGRMPLTPSPNTRATPRASDETSPFTPQKTDAGCEKPKSIYGGNLSSYFAKSSGSKTSATTKASFPKTSVPKTSVPKASVAKSSVAKSSRTHRDSPKSNIARTRHSPKHLQLGVSDWSLTGTGPSSSGQTPSKERTRREITTRPRPTKTTVRISHNAGDRFIPNRTASEGLVTSGAAKPDESQRPKTSGSEGSTVLASAASAFDISGRAIEDDLTAALDNLGLDDSEPPNYSRPAPDAVAYESSLANACGVNLNTRILAFKPPPPESSKPIDLRAQYNRPLRPAKSQNAQFRRRVQTAPERVLDAPGLLDDYYLNLLDWSSGNQVAIGLERNVYVWSAESGTVSCLLETSPDTYISSVKWSGDGAYVGVGLGTGEVQIWDVEEGSKLRSMYGHDSRVGVMGWNKHTLSTGARSGLVFNHDVRIADHKVAELVSHTSEVCGLEWRSDGAQLATGGNDNLVNIWDARSLSAPKFTKTNHRAAVKALSWCPWQLNLLATGGGSYDRHIHFWNTTTGARTNSIDTGSQVTSLRWSNHYREIVSSSGFPDNSLSIWSYPTLVRNVEIPAHETRVLHSSLSPDGQILATAAADESLKFWKVFERKPGSSASASREGGVGSKAQLTKSMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1S9</accession>
    <name>A0A1Q5U1S9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1S9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1S9"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="161" mass="17802" checksum="AC8B458FC27B6FC0" modified="2017-04-12" version="1">MDSIHARDHADYFTCERDSISTSKVAAVPSASPSPPSSRPKEDHPGQMKTGPQFFAGVLVRVPLPPSPEPAQCNTARASPKMIHSVRPISDRPVEKQPRVGMGRVIPKKFVPPNPRDMPQVLFPLTGHREFTLLPIPRFVRENDPRQFLIYADGACSNMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1X1</accession>
    <name>A0A1Q5U1X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1X1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1X1"/>
    <dbReference type="OrthoDB" id="5383057at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="244" mass="25200" checksum="877967C6029F1313" modified="2017-04-12" version="1">MDLQGTPIAPGPRSTKVTTDPRATQQPIHEPSGPVTNDSLAAESVRSGGGFSQNRGAEPAGVSGNQSTLKNTDTSAATTLPSAPVRALRGDHQRQDKYPEALGGQGHFPGAHGTGYAGGSTAAKQQMGINKGEYAASQHLPGQAAASGSSQYNNVQAPSYVNDVTDGYQGQKPKGQNLPAGGFPVDSKNASFTSAIGSEMDPGRAAENKFQRTVAESALDVGGPRQKGIDNQNLFENLKSDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7A1</accession>
    <name>A0A1Q5U7A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peroxyureidoacrylate/ureidoacrylate amidohydrolase RutB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7A1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7A1"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="203"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP08336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="314" mass="34213" checksum="7A6F2B22978B501D" modified="2017-04-12" version="1">MVPTQMIGHGATNFWRYEPGCNTIDLSRGSKSNDLISLRTTTQSTRLDPEKTALLLIDLQNFFLHPAVRPRAGDKPTPAEAATNALLSAGIPAARHHGIRVIWLCWGLTENDLRTMPPAIMRTFSCYEAGQSSKDHIGKNGPLPSAPNMVRIKNPALYKGLGTDLGTVESAANKTVPGGRVLMRDSWNAALYDPFDQEYKKSHGILGDNTQSKPDVLFHKNRMSGLWGSGSELESFLEREGISTLLLGGVNTDQCVGSTLTDAFSKGYDCIMLRDGVGTGTPFGASEVWEWNVTNCWGFVSTCEALKNASKYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9X4</accession>
    <name>A0A1Q5U9X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_5356</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9X4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9X4"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="18">
        <location>
            <begin position="179"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP09270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="42813" checksum="E2743A514D28D94E" modified="2017-04-12" version="1">MTSALNGHAPKSRLSVQRRIEHHEADVVIVGAGILGCALAVALGRQGRSVILLEQSMKEPDRIVGELLQPGGVNALERLGLRDCLDGIDAIDVDSYYITYFGEPVKLYYPKENPSSPRPIGKSFHHGRFVMKLREAVLACPNVKVIETKATGLVTSSQVQGQVLGVECVTQDLKDCYFGQLTVVADGYASKFRKAHHPHTPKVRSKFWGLELIDANLPSPNSGHVLLSDKPPVLIYQIGTHETRILIDVPDNLPSASVKNGGVKSHLRNVVLPSLPEGVRPSFEAALDKGQLRSMPNSFLPASTNKTPGLLILGDALNMRHPLTGGGMTVALNDVCYIRELLSPEAVPDLGNTAVVLKQLSRFHWMRKNSSSVINILAQALYQLFAANGMSLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCD6</accession>
    <name>A0A1Q5UCD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter CGR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_4475</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UCD6"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1220"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1250"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1279"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="115"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="804"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP10121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1436" mass="161534" checksum="BB5D6E2C8F9C62CF" modified="2017-04-12" version="1">MDKDEYEMEFMPITERTPTVIDEREIASLGRIASSKLGQKLSASASRKDSQDLRLDPNSPEFDHHRWAQHVLSQVHEAGIEIPSQSVVFSNLSISGSGSALQFQETLISSLTLPFRFASKALAGRLSPPRRIIHSFDGLLEGGELLLVLGRPGSGCTTFLKTLCGHLGGLTMEPGSSIHFEGIDFDQMIKHHRGDVAYNKEVDLHFPHLSVGQTLSFAAYARAPHQRIEDMTRDEYVETLTQVVMSVFGLSHTSNTKVGSEFVRGVSGGERKRVSIAEMFIARCRIGAWDNSTRGLDAASALKFVRALRLAADMGQSCHAVAAYQASQSMYDLFDKVVVLYEGYQIYYGPRDRAVAYFQDMGWARPERQVSGDFLTAITNPNERQALPGMESKVPRTAKEFAEHWKRSPEYQSLRKQITDFDQQHPPNGEDARKFQESHVHQQAKHTRSRSPYILSVPMQIRLCTRRAYQRMLNDLPTALSPLIVQLILSLIIGSVFYNTPDTSSYFFQKGAVCYFAVLMNALLTINEIMQLYSQRPIVEKQSGYAFVHPFTEALASIIVDLPIKIVRISIFSIVLYFMANLRREPAQFFIFYLFLIFAVLTMSGLFRSLGALTRSVGQAMALAGILVLCIVVYTGFTLPEPYMHPWLSWIRWINPIYYTFEALIANEFHGKNYPCTSVVPSYGTGTSFICSSLGAVAGERFVSGDAFIEQNYYYHYSHLWRNFGILIAFMLFFNTLYLVATEFISSDKSKAEALVFRPGHAPAHLQSGHDAEGGAVAVTRLEPTQTNDTIHLPEQKDIFSWKAVNYDIPVKEGTRRLLDNVNGWVKPGSLTALMGVSGAGKTTLLDVLAQRVSIGVVSGDILVNGQPLLPNFPRRTGYVQQQDLHLETTTVREALRFSALLRQPRSVSKEEKYQYVEEVVKLLGMEDFAEAVVGSLGEGLNVEQRKLLSIGVELAAKPTLLIFLDEPTSGLDSQSSWTICQFLRRLADHGQAVLATIHQPSATLFQTFDRLLFLAKGGKTVYFGDIGEQSSTLLKYFEHKGARPCEELENPAEYILDMVAGEGCLGVDWPQAWNSSQEYQDVISELDQLHSMRKNSSHDQLLGDDNSEFAMPLSTQLAVVLGRCFQGYYRQPDYIYAKFILGIASGLFIGFSFWKADNTQQGFQNVLFSIFLLCTIFNTLVNQIMPRFVTQRSLYEVRERPSRIYSWKVFILSQILVEVPWQVCLGVCSWASFYWSVFGTGQDSESRGLIMLFIVQFYIYAASMAQFVVSAIPEPTLGAMLATLMFGLSFIFNGVLQPPSVLPRFWIFMYRVSPFTYYISGIAGTALHGRKVECNAAELSVFDPPSGQTCWDYMEKYVDMAGGSVYNKNATSNCEYCSMSSADQYLAAREIYYGDRWRNYGIFWCYFVFNIFGAIALYYLFRVRTSKSMMGKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCJ5</accession>
    <name>A0A1Q5UCJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Riboflavin transporter MCH5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_4371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCJ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCJ5"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="238"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="426" mass="44774" checksum="C1E286A3C5F5798B" modified="2017-04-12" version="1">MPSTDPERDASLASKEIHSTNDNVNPKDIPAAPDGGLRAWLAAAGGSCIFFSALGFANAFGVFEEYYLSHQLNGKSADDVAWIGSLASCLQFMSGAIGGPLFDRYGGWVIRPGAVLYIFAIMMTSLCKEYWQFILAQGILTGIAMGLIQFPAMAAVTQYFDKKRAAALGAVVAGSSLGGVVIPIALSKMLDSTSLGFGWSVRIIGFILIPMLAFSCVTVTARLPPRKSAFFLAAPFKSLKYCLITAAMFFMFVGMFAPLFYIPTYAVSRGMETTLASYLLAILNAASTFGRVIPGVLADKFGRLNVFTIGGFATGIVIFCFDKAESTAALVVYSIAVGFASGTIISGGTAALTICVENPQEFGTYLGMAMGCASIAALIGPPVNGALINHYGFAEMSYFSGSMTIVGGFIGLAAKAVTPQGIFGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD16</accession>
    <name>A0A1Q5UD16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD16"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="562" mass="60090" checksum="4A82499900A76BBD" modified="2017-04-12" version="1">MQSSEIGYGDERPEPQPFASQGSPTKGDDAADEPQYPTGAHLWLIILSLCLSVFLVALDQTIIAPALGTITTQFNSLTDVGWYGSAYLLTTTALQPLYGNIYSRFDVKYTFLAGVFLFELGSLVSAVAPTSNAMIVGRAVSGLGTAGIFSGSMVILSYTMPLRKRPVMFGVFGGLWGISSVVGPLLGGAFTDHVSWRWCFYINLPIGGVAMVVIFFFLRITRADNPAGESLVTRIKQLDLLGALVLIPAVTMLLLAVQWGGAKYPWGDSRIIGLLVGAAVTTLVFAGVEIWQQDQGLLPPRFFRQRDVLAAMMFALFVGAYFYPIVYYITIYFEAVQNDSAMTAGIKLLPFLISVVITSILSGVVISTSGWYNPVILVETALLTAGAGLVTTFGVHTPLRQWFGYQVVAGLGTGVLFQAAILVVQNVLPPALIPQATACVQFFQALGGTIFLAVAQTVFQNGIIDTVRRDAPGVNPHSIIDGGASDVRQILARMGRADAVDAVIGAYTVGLRDTFYLTAAAAGCTFLVTWVFSWKRIQKAVGTSEADEAAVKGDGLVPETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDB8</accession>
    <name>A0A1Q5UDB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposon Ty3-I Gag-Pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000328">
        <property type="protein sequence ID" value="OKP10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDB8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="65" mass="7322" checksum="63B9502CE96D49EE" modified="2017-04-12" version="1" fragment="single">MPFGLTNAPATFQNYIHVALHDILDTFAVAYLDDILIFSADRDSHTSHLHQVLERLQKAGLYAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE41</accession>
    <name>A0A1Q5UE41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE41"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56069" checksum="D9DCBE78E47E2ADF" modified="2017-04-12" version="1">MSLFRNLFRSHKQEADAPARPRLPWLRCSQSATDVLGAHLQRIPGAAVWPRGDETGAFASGRSTPTLLPPPSPSSSGHEDPINTEPSRESSFRQNPAKSDGGESHYGSHYHLRPASVLERDPISSLSSESSRPSRLNRLDPARAKEAFNAMAARLSLRLRIPAEEPTTAEVIQENVGAGNSSQRRHRSLGRLRPVKSIMVLAKASQVAPAPSPKLRRTKTFADLLRRPEPMTSLRGIEVERLAYLGGEDFVWLPSSCAPCPVQLPNCIAKSIRYLRKIGNGTYGGDLFVEPGNLKKAIRLYDYFAHHVLSAANDEHGIAVNMRVVTMPTWAKAEKLPARSVGWTMKALLAGLPGGILGSTELYNTLKEIYHLQGAAAEAFPRAIRCRLISLAIVASTREMQCALICAIFGLLTELLEDTPGYPLREVASTSRADGLAWAFGPLLTGTEKGTGTGMEATERDREDVQVKGAAQVKREIEAERVAGMLLDLWPDISYNLKGWAKIYTTHLAEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEG5</accession>
    <name>A0A1Q5UEG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEG5"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="668" mass="75596" checksum="2E834C0D687A8BC5" modified="2017-04-12" version="1">MARMSFDRLPTEIVSMILIDLDSVDPSGLLAFACTNKAHFAAAVPRLYKTVRIWLEDESPATISEKANQLLENLTRREVSQHVRFFILDSQKAIGNKKVALTAKHREHDSLSSQMVNRVPIVFRVRRIPTDNPHANDVWRPVANLVRALPGLVDFFYTAEYQFAPCLLEAMHESTPKCRLWLNTFKLHSLRDSELDPHELALVTSRCLHSIKYDGEDDGNRGRDGRRPFNDWKGIYHVVAELAPTLQNAYMRCYLNSHRIVLANEESRNPGFLNGWYKKPAKKGSLQSLNIGDSDFIDVKLVTEWDAHTDFPALSSLVLGGPIDEAALIYLASTCKLSSLKHLTLNLNPYPRHLEPNVRRRELTTAHQSGIQFLLSLRPLASLTLKGWNNSHSITPVLSLHGRTLTRLVIEPYKENPLTASDITTMALLCPSVQELDITIARSQGDSFEVEKYRSLGKFRALRDLTLRLDLTDIKLLLPELDEDTHNGVPVTPIQPFFDEFDIKPCEISPGPNGSVCNRLSFRNGDIRQMLVNAAIDEALVKRIFQIVEESKGTNSSARSLQSLEVSPCGKTETWDTLGYNGHVLFDGVPMAMERTWLATRALGVGVGIEVVQTDVAAMKGRLAYQKSFWEWRDDRLPAWLWPTFRHLWPTKNGVSWQDDWHSLPLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEV4</accession>
    <name>A0A1Q5UEV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEV4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEV4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="450" mass="48144" checksum="2FDCDA9C3304095C" modified="2017-04-12" version="1">MDRPTSEYAQSGSHHPPPTQPPSSSSHGNHSDHHPEHPADQTSAAAAAAAATHYTHTPQPEVRPNPQYSHTPQPEARPANISSSNTPQPEYGLNPPPARSPAYHQDYLPRPPQSYAPNSQPGGAPGMAQATSPFLPSSSKSSSASMPPPHSSASVPVSDPAATSRSPDLDPALTSLHSASSSNFTSDAAVPLDPSLPANSPTYPPPYSPYQPQGHDMAQYQGHPPPPHQMYARPDWPHSYGQQHHGLPGPYASPAATTVGSASPAATAGPRPGQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRTPEEFKEIRKEWKARKKEEESQRKAAEERERAAAQAAQAGQVDAPGSSDPSQGGQPPAYASGVRPQLPPIGYQPADGQVPNQYGGPGGGMVYQSNGQMGYPPNYPHSPYQSGPVYQQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEY9</accession>
    <name>A0A1Q5UEY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBP3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEY9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="133"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="31657" checksum="B237092470692F75" modified="2017-04-12" version="1">MSTARLSTLWVRELRSSQSQCLQRQLNQRAYLSSTTSAPICGGSGSCNVTGKSRLASSTSSPARSYSQGSAISRLAKSALSPGASAETYIAYGMTQKLFQACSSQADYQVPQASQKGVAVPTTESGEHLGTSESWWYKVRLRALPNRESFQTYSRHLIDHFSHNAEHRMDDLHDIGSRSIRNKYLKDLFIQWRGIIAAYDEGLIKGDAVLGAAVWRNLWKAEATGPDGSELDWSKVAWVVAYMRRVTAQLARMDEADIVMELSGASGQESKIFGFSELDRKIVEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF41</accession>
    <name>A0A1Q5UF41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF41"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000425">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52447" checksum="45D63CFA07F34EF6" modified="2017-04-12" version="1">MIQLPHVGPANDPAHLSDKDAALAVVSDVAQEIDPVAILGSAALFGMTTDLSLKVTDYSTSPPSVDTSRLSWATSIFYFGMLVGLYPMTFVLQRFNIRHVLGPVVLLWAIVCAATAGVTSWQGLFVQRFFLGFIESVIPTSFMTIVSGYYTQEEQALRQAWWFSGTGWFTIIGGAMNYGFGQITSGSLTRWQYIYILAGALTFLFGLWCCTIPNSPVSAWFLTPEERMVAVERLRKGQTGVRCQKIKFDQIKESLTDIKIYLVAVMMASAYTINGAISGFGPLIVSTFGYDTLDSILFQFPVGGICVIFIPLCGYISTVVPNTRIPMLITCCLPVIAGCVMIWKSHWGYHPAVPVVGYALTGFFGPVVSLIITVGASNVAGATKKTIMAATVFVAYTVGNIIGPQLVKSNTKAQHYPELWTGMVICYSITITAAVALYVVLWRENKAREAIELDEVQRDKTAFDDLTDKQNPFFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFV6</accession>
    <name>A0A1Q5UFV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000285">
        <property type="protein sequence ID" value="OKP11351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFV6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFV6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="42820" checksum="76551878C267E991" modified="2017-04-12" version="1">MDNIFDLIRTSGRGCYIIKRDIKDAFRNIPVAPADWPLLAFSWDSKTYMECCHPFGLTTAPFIFNLFAEGLNWLLTAYLPVASIAYYLDNFIAIFPSSVGGLSKALTAFNTVYIPLTDALGIPRNDSKDAAGTVVSVLGVEIDTTLLQARMPRDKLARASSEAASLLQLDRVSHKALQRVIGFLQHCSMVIRLGRARLQSLYSDLASFPPHQRSVRRLSHDSRGDLAWWRDTLPLFNGIHFFEKSRPLVALYTDACDSGLGHFFFYTPSWDSARDWMSAAPHLPSTHAAIVDASSACGDVAHINIKEVSAILQAFLIHSPHWAHHLVLAFTDSAVAFHGLSKQALRGPVLCSMKNFKGSKEAPKLTIRSLVTPYFRVWSKRKAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG91</accession>
    <name>A0A1Q5UG91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ4</name>
        <name evidence="9" type="ORF">PENSUB_2977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG91"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="1 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="32763" checksum="0BB96E42E691B7B1" modified="2017-04-12" version="1">MSVLGRRGACKLRALASSRSPSTASSLRPFSILNRPQPNYPGHVPLTTIERGALAVGSAIGSLINPRRADLIAALGEATATPYFIYRLRDAMLSDPTGRRILRDRPRITSETLQMSYLRGLPENSVGRTYATWLDREGVSPDTRDNVQYIDDEECAYVMQRYRECHDFYHAVTGLPIFVEGELALKALEFLNTLLPMTGLSLFAFIRMKPAEKERFLSLHLPWAVRSGLGSKELINVYWEEVLEKDVDELRAELNIERPPDLREIRKMIRQQEKREKERLQQQQMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGY1</accession>
    <name>A0A1Q5UGY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGY1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGY1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="452" mass="48921" checksum="329247FC1C51BAAF" modified="2017-04-12" version="1">MSSTPVLNVGILGATAATESIYIPLLSSLPTHYTLTIIHTTHTDTQNNLNSSITTTTNPDEVINHPDSTLIINLLPFDHHETYTLAALESGKHVMVEAPLSLSIHGLRRIRDARKKGSTKNSNLNSNSSSQDENSKSAGPKVFVGCVRRYAPCFKDIFKAELSTLGRVYYARCRNITGPSVPALTNTPGNGYINGTNGVNNSLLPSSSTARPQRIHALLADIFGSNEDLTRDREAFCRFLGTLGGHDLSLIRESLGFPDAVSNISIIEPFYSAMFHYTDNTRGTGYPFTLVYEAGVDGVPRSDAHLTVYGAKKTLSIEYDFSSGAMEGNVAARVVVEEAISGSVDDVEMADSRDGKVNGNAGQNGHVNGNSVANGHSPTTRPRMKRTEFVSTAREAYEQEFLAMHAYLVGDSGDAGVEAKTTAEDALDDLKLMHMIFDHYDRQCGTIRTPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHA7</accession>
    <name>A0A1Q5UHA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHA7"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="12154" checksum="A793C283C7CDE711" modified="2017-04-12" version="1">MVYTIVVHLRAKPDAESISKLHAKLLEASAIYSKDKETLSWFVMQSVHDKQDFTIVERYERESSQEYHLNNPYWKTFDPYVIPLLEREMDLRRFEELESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHF0</accession>
    <name>A0A1Q5UHF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_2553</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHF0"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="56"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="41876" checksum="7AAB1AC8F30055E5" modified="2017-04-12" version="1">MERLRDSAALPLKSASTLVSPGSFLFNPNSAKPSGVPVSRPPHRRNMDKSQQPSSFQQLEKLGEGTYATVFKGRNRQTGEMVALKEIHLDSEEGTPSTAIREISLMKELKHESIVSLYDVIHTENKLMLVFEFMDRDLKRYMDTRGDRGQLDPATIKSFMHQLLKGIAFCHENRVLHRDLKPQNLLINKKGQLKLGDFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAEMYTGRPLFPGTTNEDQLVKIFRLMGTPSERSWPGISQLPDYKPTFHVYATQDLGVLLPQIDPLGLDLLNRMLQLRPEMRISAADALQHPWFHDLPQVQAQLQQQQQQQQMAGGYGGMVPPQSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHH0</accession>
    <name>A0A1Q5UHH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHH0"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="16793" checksum="3F27D47F27505CC5" modified="2017-04-12" version="1">MGRLHSKGKGISSSAIPYSRAAPAWLKTTPEQVVDHICKLAKKGATPSQIGVVLRDSHGVAQVKIVTGNKILRILKGNGLAPELPEDLYFLIKKAVAVRKHLERNRKDKDSKFRLILIESRIHRLSRYYKTVGVLPPTWRYESATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI73</accession>
    <name>A0A1Q5UI73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI73"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="198"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="418" mass="44820" checksum="930D5894029775E2" modified="2017-04-12" version="1">MHVPEAQRPFLESVQEALRRYDEQLKDINHKIWSNPELAYQEYQAHDHVCELFNSLKSSGYQVRPKAYGLETALEIEFTHGSGGRVVVYNAEYDALPGIGHACGHNLIATSSIAAFIATCEAMKAQAQSSGISGFTVRLLGTPAEESGGGKVKLIEAGAYKDVDACLMVHPVPMSPNRPDVHGVATVVEGGYLANDKVKVTYTGKPSHAAAAPWEGINALDAVVSAYVNISLLRQQILPSQKIHGVIVNGGARPNIIPMSASVDYYIRSPTKKTLKPLTEKVMQCFEAAATATGCKVEYEWGVGYDDLKANMPICESYVSAMRAMGHHTLLDNSEQKGALAGGSTDMGNVSYVVPGFHGVFCIPAKGVNHTPEFTSGAGSPEGFERAIACAAGMAVVGCQVLVDDKFAEAVKKDFQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJX5</accession>
    <name>A0A1Q5UJX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJX5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="16060" checksum="C50F4870AD1CC221" modified="2017-04-12" version="1">MVVAMLLDETRPASSIEIYFARCLGFSLLTIAILTVMLTGSIPLTSSISEPVTTEESDPKAPYALPTLMITSFFHSISAFYAYTRYVTTGQGFFAVAVAGGSVLASIGLWCVLFASSDGKISRKTGADKRTTGFPFANSEAAKKHAGKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJY4</accession>
    <name>A0A1Q5UJY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein MON2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UJY4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="198"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1007"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1721" mass="189879" checksum="5210348E4DD4122A" modified="2017-04-12" version="1">MPISERLVEVLLCMADRTLTRRIQAAEQSLNELKALPSTSEAQISADLVRKSTFVEPFIIACRTRHAKLAGIGVICLQRLIASRSLPSHRLKDVLAGLKETTGLSLDIQLKILQSLPSLLQFYSNDLSGDLLANTLEICVTLQASKTLAVSSTAAATLQQLVVSTFERVSNEDKLPNDTKSFTSVKVDGHSVEVAQFAYDALQVLDDLCRLIDGEQLQFLRTRTLSPTFVLELIESIILNSGRLFVGHPELLQVLRVRLMPLTVRYFSERHSFSQTVRVARILLVLLKRHMSLLTAECEMAFGLLTHLLEPDGNAPWKRVLCMEVFRGLYGEPGVVRLIYSLYDGDENRKNVLRDHMASLVRLASEKPSLIGVSNQSTIPFRAEHTRSATEDQIALETGGVAGVIGSTGPSAEIKVPGISMQWSVVRTPYIELLDKADPPLPPETYIYSLVLNCISSFAEGLAKFILPLTVPDVKSKKKNRIMNQDQATDSARLSQDLQSPDTLRAQAASPSGKSSVPVNPLELQSHVQYSAIKTCAGIIDNCWPAVLAACSTFLHASLDDEYYHNLVRAFQKLAHVAGLLRLSVPRDAFLTTLGKSAIPAGTSGTKTQTPATPSLGGPQSDNTPQKSRKSSDMPRSSSLSGDSAGSSAVESSSASLSTRNLLCLRALLNLGIALGPTLDQPAWSILLETLQYAGLVIGISSSTMIKSASASGETTVISGNDIPTANLGAEVIAVQSASSKMFESTSDYPSPSFREILLALLNLSAFTEQNTKQEPTQEVSEPPNSPQSSRKSGRMHQNARRVSHTVGKFRMLDEELKFVLEKGNELARANLDRLSSLDEENLAAWQLLSGSLIATSANTAISPNLRLQASSILNSLIYLTMKSREADDDQTRNKVQTRNLQTLKDQVTTLYSSDQVTAKSLPITVIEIHEQSLEILHNILEQYAEMLVDGWTSIFDLIAGVFRGVCLADGSSTQLTTPTERRRSALPGGPRLVRAAYKSLHLVASDFLSLLPAPCLLALVNSFSSFASQTQDFNISLSTTSFFWNVSDFLRGQIEEFAVESHVDTSVSEEELGKLTCDQDPSVSKNSLWLLLLLRIVGITTDTRSEIRNSAIHTLLRIFDAYGQQLSPQAWRLCLNRVLFSMVENLSSALYEAKKQETAKDDLKSWVETTVLMIKGVLNLITNFFDTIVSDENFGQSWTRFFKYLQGLLDMHLLEFSEATFASLSAVLVRVQSSEGLSKEARECAWNLWANGHPADDETAIDLDRPNQDAALAYMQSFQQIYRLYKDHLGPENIEKVLQHLRLLVWNSVSPPYSPDVDRPSALQALVIECIKTLCMEKEESQAAILLCLADLSDSALTKWRPGNDSRKPGFVAFSKTTIDLISWYIADFGIKQDILTNDALASTLERFGALILQKYMWEGKDREPYMWQQASTASLDVLQVAVPYAEKQYDTASEADIARFWRCVVDITHGIVSAHGFQTQQLSNARIVADEAFDIASFTRLKTLVLPSLGASAIPDAVRRNFALALFHSSFIYPPQRLDLPSNSIEKDPLQDFYRIRPGRTFDPPPTLRPNMAYTLIDTLFELAESPESDDSKPCPRTLLACSISPYLLLRCAISLKGYIADQPLRGLMPQPTPACKVLLHLLLRMVRLQSEPSAIPDPPSIKTVMSTDDASTACHHRKHLEWMYPLIVKAIQVAGKERDDGQVLQALGKVLQEIGQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK09</accession>
    <name>A0A1Q5UK09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK09"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="194" mass="21444" checksum="7FEF24BC1BB4A26F" modified="2017-04-12" version="1">MADEISPCPFCNIAASNPPAPFNDPESGSSLSESTSDGTAHLILSTEHVLAFLDIMPLTNGHVLIAPRRHYEKLGDMGVVAGQEMGKWLPIISRVVTKTIFGDDPDRHWNVVQNNGTRAAQQVPHVHFHIIPRPSDFAHKPSFAMFGRGQRHELDDDEGAALARAMRVELELEIKRIQKEEGVDLSHTSEKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKW9</accession>
    <name>A0A1Q5UKW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKW9"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="26701" checksum="5022EA4651E27B38" modified="2017-04-12" version="1">MPGPIEIVEPPVVVRDLHDDEKLVVDDFERHVSHCTQCALALESASDSLCERGQHRAIDVTKYLYSVDGKHFSVVDRENKKPMRVKLLRQGSHARTLIENIDKGMRLTSPRRGRAPPVMPPSTPPQSSHRRSTSIRSSYDATYPVGPRRSGPVVEHREPRTRSNTQSPQPSPNTRIIERSPSNSKPRVVVYPSPHTSPNRSSNSRGSLYNSDRQDRVDRQYESTHVRRHPDYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULK4</accession>
    <name>A0A1Q5ULK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7533" checksum="3721F94379357460" modified="2017-04-12" version="1">MFGNVLNWFSSSKQEPTNGATWDATTTSVQNQQPTSPEAPSTERVAAEQPNSQENMMKLRGGGAGDVCCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULW6</accession>
    <name>A0A1Q5ULW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULW6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="22289" checksum="763667487930EE2B" modified="2017-04-12" version="1">MSEQKFSPVTPVPNNNMREVLERFKQRRLKSEAILRALKEQDAAMGFGSFNDMPQLRRSNSQEADEKKSRVDFALKNFTNTLSRTLGFLEIPFLDYLAATTTMSVVLAIDHERQKIRFPDLADSEPKNAEYEDLEFYFHKIGEAVIDGGEDLDDASQFTEETSSLRHTLALDIIRLGLRQLAQAQLESGKRSLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMC4</accession>
    <name>A0A1Q5UMC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMC4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="33751" checksum="A1AEA61FB14A0CFE" modified="2017-04-12" version="1">MSSSHIPDYEIEEPSKRDPTIETCLNGADNLERLLQKDGFTKWGFVIYRCTYQSQKDWERFIARFLQPVTEYLEDSKGLDMLEGFTPTVFEDLLFNKATTALLRTHFRKWATTAPLQEQGIDTFGHSGRYRFFIMVDQEVLESVLDSDPDAITRTGFVRLVYGEWEPEVNEDSNESVDSDKEFEPLEGCTQEDVGWMKVPYDEIQAVGALTMRDMDDWDIYAITHQSLPNYATLVTGDFFNMVPESLRTISRSIQNFGLGSLGRNETNVTNGNLFGLVDSSNAHKEAKLGGGDQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMC7</accession>
    <name>A0A1Q5UMC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein C25B8.19c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_813</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMC7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMC7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="135"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="33338" checksum="D4543DB14DE87238" modified="2017-04-12" version="1">MDLASLLHGAAPAPKLYTETYGKRSLQAPLSPPVEDQPKCSLPSISTLLEGAEHSAKRQRLSPPAHQRDARYDTICMPPTPPLRPGSGSGHSSISHSPVELNTPKHTSPHMHRSSISSTTSSTAPHHSHSHSHSHGPYASPAPSTSSTGSTYTSPVETNPPNNNTLYYPRPPSTTTFNPAPTTPALNTTNIPQSTHQQPQSATQQSPSALISPVTPAWQHQHHHYFPPSSAAPYQQNHDRYICRTCHKAFSRPSSLRIHSHSHTGEKPFHCTHPGCGKAFSVRSNMKRHERGCHSGRPAVPAPQALVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMW9</accession>
    <name>A0A1Q5UMW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IQ domain-containing protein IQM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMW9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="34102" checksum="6C2307EA8E2638E3" modified="2017-04-12" version="1">MPPSVPEEQAASTIQAIKPPVQDHADDSANPYLVSDVEAETDPSDSLSPARKNWQRAVSAALQASGDGGSSVDQEGHVHPDDYTDLHTPTCPPKTMGLEYFLEMVDSKHRHGSNLRAYHAAWKNSPSSQNFFYWLDHGEGKDFELPQCTREQLEKDQVRYLSPEERFNYLVNVDDVGLLRWAKNNELVNTDNKRYKDSVHGVIRVDENIPKHGAPSGQDSVTSPASAPTSSGQLSSSIIPGNERKKDQVLSTQEDHEFDKAVNNFSRIRPVVIYDHFAGSLSIKDGMWIFVSDHTNNIKNNSSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNK9</accession>
    <name>A0A1Q5UNK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="5 15">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_324</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="5 15"/>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNK9"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF4">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="17">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP14055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="41995" checksum="46DF1D265442E26F" modified="2017-04-12" version="1">MPPSPTVVDFRQEWFLRFFWYPSIPRRWVKMFILLGLLCLFTVSLSRSLNLRDEAGLQSDNAVVHFPPPRQTGQHTHDPNIIRVGDTYYLYHVGEHIFIHTAPTLAGPWRHVGSVLDANSVIPKGDRAVPWAPTVVAVDGTYYCYYSVSKAGCRDSAVGVATSQSPGPGNWHDHGVVVQTGTGNASNVAPYTISNAIDPATLVLPDGSAYLTFGSYWTGIYQIPLGKDLISPVSTTQPDARHLAYEPNAISAPNRNANSLCGDPTGPHAIEGAFTSYHDRYYYLWFSHGRCCDLDRGKLPAAGSEYSIRVGRSKDPRGPYIDQSGKNLVDGGGTVIYGSNAETYAPGGQGVIRVGDTDILYYHYRESASTHHILIFILDYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNL7</accession>
    <name>A0A1Q5UNL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012502359" description="Cell wall mannoprotein 1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14695" checksum="6D5FD5ADD81228A7" modified="2017-04-12" version="1">MQFKLSTIVSLLAVASPALAVDAVSRIDSFTVLAKDVQTTANSIELTNALSKASDTIDRFYLLSDAERVAKNDLVRKGEALAADQQQAACNSFTNDFADLLTELLAPSYRSSLADTIKDLEKLLTSTKKAYTYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP68</accession>
    <name>A0A1Q5UP68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_40</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP68"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="356" mass="39516" checksum="4D570BEBBB8669EC" modified="2017-04-12" version="1">MVSSTGIKTRICMISDTHTAAPYSPLQTSYAYRSPLPKADVLLHGGDLTKVGYSVEHEAMVSMLKAADAELKLVIAGNHDITLDEEHFTTFGYRRHRRPEWLGGKGILLEDDEKSLSNAIRAGDVPAADKMQAYVRRVKNMYTNESARAAGIRYLEEGVHSFTLSNGAKLTVYASPYQPEFCRWAFAYPRSQDRFNPPLPGSSNPQPANPVPDFPNVDIMLTHGPPAHVLDLVGRDEGHQQHVGCQHLLRAAERARPRLYMFGHIHEGWGAIRGSWNAFANGGIQLEEVPTDKEDMLERRGAYYDISSGSQRPLRVGAETLFVNASIMTLGYHPDNAPWVVDLDLPPADVQMPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPN9</accession>
    <name>A0A1Q5UPN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_14052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPN9"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="277"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="615" mass="68686" checksum="FCE8BFFEC7D71B2D" modified="2017-04-12" version="1">MDAPGGVNATTEHDAGVRRERPWLYASNRKLRHLHGISVRNLVVTPPPNRARGKTIDDDDIPNTLKSPSKLLAQNENRPLQPSRSFTDLKLRPIQDGPADKRPDMRESRRRSLLPWNDPNPHTRQIRLEDITKSRMADTFFSLHCDRIEEPVYISEVVDKGTNPSFRSFDLDFCGPVVSRRDALTLKLWAKTEKTSEFVLLVELQQHLRSLQFLGKTLESFHHPLPANCILFHFPDGVYTNLTDIPPVEQPLNSAGQRSTADGAVLPTSSYDALMRLANLDECIQDALATREKLETQIGEILKKNEAALLTESEAAKAQDRLASIKQAVAAERKQIRAANKRKEDLIASIRARKESMEQGHLAQEKARSHLPDAQEKLVSSEQLLSQNAEETKGQIRRIAEDLMVIYPIDPIPDKTLAFTIAGLPLPNSNFDDIDREEVAAALGHTAHLVYLLSFYLSVAIPYPISPNLSTSLIQDPISQDLPQRTFPLYPASVQYRFEYGVFLLNKDIEFLLNKQGIRGLDIRHTLPNLKYLLYILTAVTPDIPVRKAGGIRGLLSGRFTPTMSRRGSLDSVVSGELVQPRKALDLVSRMNGFALDHGAKVPAGAPTPPLSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPQ3</accession>
    <name>A0A1Q5UPQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_14061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPQ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPQ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="243" mass="26926" checksum="7DFE93CFCFDCC44A" modified="2017-04-12" version="1">MIQQTDSSQLANCDHIPVIDLSSIDSASLEGRQKLAQTIFEACTQVGFFYIKNHGIPDSLVDGIHDAAARFFDLPEEDKMKFYIGNSQKFRGYSPIGGEKSTGTEDDPIPEEKAVGVLSEAFDIGYEVAMDSSKSKDALLPSDPYELYGDNQWPDEETLSGFSEMYIKYCVSALDLCRKMMKIFALALGLPETYFDSSIRTPGVTSRMMHYPAQPVAGEVQEGLGAHTWVREKLSRAYVGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPT8</accession>
    <name>A0A1Q5UPT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="41633" checksum="C3C50BAD447B5654" modified="2017-04-12" version="1">MDALPTFTNQRLTPKCKLEDFREFFDFKVGPWKTFHRQFKEYVLLSSTWAEVWESTATREAVATTFLEQVGSEYWGKENQEKYLIQAHVRNGDVCVFPRDKKILIKALALLLEKDSKNRRESASQDISETQSSPLSDPPASDFEMAAPMKQSSSRASTPTGLFRIPQSLQTPMTPQNPQITPSARGTSLMGAERTTMRPASTTPTPMSRAPLDTVESMDTVESTAMVSSALATQGTPNQEVTQHCCQDIAPNTLATYFLVQEYGSQNAPVYVPFRNFEDYRTTDDFLDEMEKRCCCEHDPPLLQLFEGVRQFSQAVVLLQWSGVSFVMRRGTDDLRSLANRIGCAWRAKEEGELRTFEFVIRVTLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPU1</accession>
    <name>A0A1Q5UPU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_14000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="374" mass="41179" checksum="261356735DF669A6" modified="2017-04-12" version="1">MTVDFDLRSNFVQIINGKSSPTEFTRHGLNPATLEVLPEDRKKAVLAYADAIDEYSDQFRDLLITEQGKPIFQATLETNNAINWIRGMASLPLIEDVIEDDETRTVITRHVPPSVIGAIVPWNFPLMLATGKIAPALLTGNVIIVKPSPFTPYGGLKLVELAQKFFLPVVVQSLGGDDNLGPWLTSHPGIDKISFTGSTATGKRVLQSASGTLKRVTLELGGNDPAIVFPDVDIEKVAEKRIYVHSSIFEKFRDALVRQVESYTVGDGFKAGISHGPLQNDMRYSRVKTFFDDIEKQGWKVATGGRIEPSYGYMVTPTIIDRPPDNSRIVVEEPFGPIVPLLSWDDEAKVIERANNTSMGLGASIWTADLDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPZ5</accession>
    <name>A0A1Q5UPZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPZ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="96" mass="10389" checksum="2AD60C4576B0E270" modified="2017-04-12" version="1">MPMASWLNGSRVIAFIRHCHCHRNYIPNLKCPKATAQQSVNASSGLTTGTKAGIGVGVAVGAIYTLLALGLFVCRRRKRQAQLDPNRVRGSSKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPZ6</accession>
    <name>A0A1Q5UPZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPZ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="20265" checksum="6A2FE6C5EF4ACA49" modified="2017-04-12" version="1">MDQVLEMFLAEGANPNVSLAGSAVWAFFVLDLPELDLTPSERDERKSTIELFLKHGANPNGVYKDTTIWKRRLECLYRRKDLTKFEHLYPRVFKDVKSLLLAGGDPDVSIWKEGKRKRQLSTKLIEYPNFQSIDDAFEAISYPDDKDALFKILRQKRAERGIISKFKTWIGPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQG1</accession>
    <name>A0A1Q5UQG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQG1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="197" mass="21483" checksum="07CB73EAC2F0C2F4" modified="2017-04-12" version="1">MPRASPRSTRLRTTHYGTLLGSQVFQSFVGGIVAFRALPRPQFATLQTAIFPVYFSMQTALPIVVALTASRGGQALGLSGLAAPENRYNTLLPMATVAITGLINMFVLRPLTTKTMRERKHQGESLDYLISSSIALELTGCLETRDGKKSYDAPPHSKEMVALNKKFGRIHGLSSLVNLVSLIATVWYGAVMSKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQU5</accession>
    <name>A0A1Q5UQU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQU5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="276"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="526" mass="59243" checksum="0520570F99028F18" modified="2017-04-12" version="1">MSTDQKRRDLMESTQSWPLMVHMGRTYIISNVNPDHKTEHSSWETPNPSYWTKHGYVVVRADETGTGQSPGFLNSLSAATIDGFCELIEWASKQNWSNGKVGLLGISYFGATQWQVAARRPKGLAAIVPWEGFSDFYRDATRHGGILSNAGIDTIWKRQIGSNQYGLPGRAARNWGDDTIEGSLSEAELAMNRVTPIEGARKDRFRDGARFASVNFNLEDIQVPLLSVANWGGLLLHLRGNVQGYIHAGSDFKYLRFIVGRHDLPFYYAEEVEVQRSFLDAFLLGHDRVGWSKRGAIPPVDLILRKGNVGYNDPKAESQFLRRTENEWPIARTQYTPLFLHPDGGLSWSKPVTDHMTPRKVEYQAFGDGDDSRAFVSFTSAQFESETEITGHIVVRLNVSVSRRRWQSTTPSDIDLFLSLRHISSSGDEVFYTGTTGEPAPVTKGFLRVSLRRTNPQHPRHRPWLPHRDYLSTDALSVVPNEVYTVDVELWPTNVILQRGEHLVLDVGASDLAGSGIFQHNDPYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQY5</accession>
    <name>A0A1Q5UQY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase I subunit RPA12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_5482</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQY5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="15159" checksum="C9404281A32A9F7C" modified="2017-04-12" version="1">MSAIGSLIFCTDCGNLLRESTGDENAILHCNVCGARNKDIIPQTIVSESKPSAFPSALRSKRSAVQTLSAEDRKTEAVTNHTCNKCGRTEMFFTTVQLRSADEGSTVFYRCVCGYKYVFPRGKLHITFPIQSNTNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URI1</accession>
    <name>A0A1Q5URI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URI1"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="213" mass="23377" checksum="E99399B76FB80456" modified="2017-04-12" version="1">MTILKARTIYLGSLIGDLQRDNTATFHFLEGELDSDPGPGIAGFYDPPYYSYYRFPRTFSATDDDETDILAAYEQLDEAIALHGPFDGVLGFSHGGTLAAGHLIHHAKMSPGQAPPFRSAIFVNSLPPFRMHPGQRPVIEQGLEGWIRIPVVNIAGAMDELFEFSLALYRICDKSCSSFVVHGKGHDVPTDKKNVAIMAGAIRKLSVKILGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URJ9</accession>
    <name>A0A1Q5URJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URJ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URJ9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012140658" evidence="6">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="405" mass="45164" checksum="CE17B4C3DA7AEAF8" modified="2017-04-12" version="1">MASNNVAIIGAGLSGLALALSLHKQSIPCTIYEARSASLDIGGAIMLSPNALRILDALGIYEKIKPRGFEFTNLHFYTDKPLDSYEFGNREKYQYDALRIYRYELIDALLTAVKEKGIPIEYGKKFTRILTESETEVTWEFEDGKTGQAACLVGADGIHSRVRNYLYPNLEPQFTNAVGVTAAVPTSQLKGTDAYEMPVTIMNPKHGAFVIAKQLPDGSEVLIGKQKRAAELGREGWNKLLNDKQWCVDFLREGSETFPEIVQSSVSNIPLDRINLWPFYVVPKLDTWASKHSRVVILGDAAHAIPPTAGQGINQAFEDVYIYALILSKCQQHNLEQGLKVWQKGRQERVDLVLDLNAQIDARRMPKNPMSAPLDLDAQPFDLAWLYSPNFDEMAESWLAGVGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URT1</accession>
    <name>A0A1Q5URT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000018">
        <property type="protein sequence ID" value="OKP15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="21660" checksum="99E90E7D3FD7BC7C" modified="2017-04-12" version="1">MGIDGRVLHGFRFLLTRVLDGYISQSTITRLLLYDIPRRDAKGYGAPYRDLPANVGPSFEPFDHMSIGVPPHLLRYMRETPLWKACEAFCPKGFAGLNSLALLSERVDSASRYLLESRSDDKNEDTESRFKTAIVFGERDPLGRGYKTALSCVIGKRNMVDWALDGIMIENAGHYPMEDKPENVAQLISRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URT2</accession>
    <name>A0A1Q5URT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein ras-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URT2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URT2"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="243" mass="26718" checksum="3326C91E73B4151D" modified="2017-04-12" version="1">MSGKMTLYKLVVLGDGGVGKTALTIQLCLNHFVETYDPTIEDSYRKQVVIDQQSCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSITSRASFSRITKFYNQIKMVKESASSGSPSGPSYLGSPMSHTAGGPPLPVPVMLVGNKSDKAVERAVSAQEGQALAKELGCDFVEASAKNCINVEKAFYDVVRMLRQQRQNTQNAKGRGGGAQGFSGHRDRDAGPEYPKSFRPDRRHRSRITCVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URV8</accession>
    <name>A0A1Q5URV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-arabinitol 2-dehydrogenase [ribulose-forming]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URV8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URV8"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP15197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="31289" checksum="46EFC1A03D75DC52" modified="2017-04-12" version="1">MAPSFSLDHTTPAVVPESNETPAAFVPTRDLFSLAGRTVVITGGGRGLGMTLTTAVLEAGGEVACLDLLPEPSPEEWIAVQKLAKSCGLQATYTKCDITNEEVTKGLLEKIAADALSRNKPMRGLITCAGIQQMVPALEYPIEGYRKMLDVNVLGTFIPAKHCARIFVEQKTAGSIVMIASMSGQIANRGLTCTAYNSSKAAVHQMCRSVAQEWGQHKIRVNTLSAGYIRTAMTDALLKEKPEVEETWMRGALLGRLGAPEDFKGPTVYMLADGSAWMTGADLRVDGGHCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMR5</accession>
    <name>A0A1Q5SMR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_13861</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMR5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMR5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="423" mass="46791" checksum="6B67D466CF3ED59E" modified="2017-04-12" version="1">MAQYFFDLLYNFTDCMCCFPSTPQLKINNRSFKLLRLLGEGGFSYVYLVQDKTTSELFALKKIRCPFGQESVSQALKEVEAYSLFTSTDNIIHAIDHCVSKESGSKFRSDGGEPGSKTVYILLPYYQRGNLQDAINANLVNHTRFPEKRLMMLMLGVAKALKAMHQYRVQSGSASTRKAKGVRREGEEADDERTMQMKPKRRASHRADDEDEENEPLMDDEVTRSQEGVQEGGLRPYAHRDIKPGNIMIDDDGQTPILMDLGSLAPSPIAITSRSLALAVQDTAAEHSTMPYRAPELFDVKTGSIIDTKVDIWSLGCTLYACLVGKSPFEARSDETGGSLSMCVLGGDWRFPDEKTTATKGKGKVGVDADNSSGSSEQVISAPVKEVVRKCLQVEAAERPDIDELIQIMQDVISELPDDDGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT9</accession>
    <name>A0A1Q5SNT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT9"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="133" mass="14789" checksum="4BAEB00DD22E68AE" modified="2017-04-12" version="1">MSFNETSCDIHLSAEGDGTHLAAICNNDEGSGLTTDLLLDRCLGNRDGKINLMKRRSNRDFNLLCAVGHFEWGGTNFSKSAKNITFSTERPDRKPILCSELRNSSGEYVSDKIDLTDHIANVEGELQYMQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNX8</accession>
    <name>A0A1Q5SNX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="49" mass="5331" checksum="1ED0E984B9D4F35B" modified="2017-04-12" version="1">MNPDIPLPPSVTDSQQPPSSGTDYNPVSTHVDQRPSKTSPEMTYRSSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQW3</accession>
    <name>A0A1Q5SQW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-glucuronidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQW3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQW3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="3">
        <location>
            <begin position="140"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO90389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53241" checksum="6DFE5798D5DC219F" modified="2017-04-12" version="1">MKIESGLDGWLRYAELPTESRKTARHYSGIIVLDRDETSPVYTAGKELQDGLNRILGQRVDIDFELPSQSSSLIVVGTIDSFSAAGGNIKEIPALKEDGFWLDTHADNNCTHIIGQNERGAIYGAFEYLMRLAQGNFGPVASANNPSAPIRWVNQWDNLDGSIERGYAGPSIFFRDGEVVDDMTRTAQFARLLSSIRVNAVVVNNVNANPKLFSETNLDGLQRIANAMRPWGVRIGISLYFDSPKEFGGLPTSDPLDPAVNSWWKEITAKLYDKVPDLVGYTIKANSEGQPGPLTYQRTLADGVNMFARALKPHGDGVVMYRAFVYNHHLDESVWEHDRANAAVDYFKELDGEFDDNVIVQIKWGPIDFQVREPPSPLLANLRKTKAAIEFQVAQEYLGQQSHFVYMAPLWREVLDFDMRIDGKASHIRDIFSGERLGWNRSGYTTVQATQPGLGIIYLSLTCMLMAGLPGTPSQTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRB9</accession>
    <name>A0A1Q5SRB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRB9"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28434" checksum="47C92A86B6FB5DC3" modified="2017-04-12" version="1">MPSESEPLLGNRHPRQTSARSQRLSRYFHDELDPRRGDLLLLFCYIITGLLDSSAVFIWGSFVSMQTGNTVYFGLGLVGTDDDRWIKSGVSIAGFCLGSLCFAAFHRAFSPRQRWVLCASFLTQLACITAAAIIVTLYRPSRDAPLSWLVLAPLALVAFQGSGQAVASRVLKYNGLTSVVLTSVYCDLFSHPDFLSPKVVGIAEEMRRTGAVVCLLFGVILGGLWAHSSVGLMGALWTAAFLKAGIVLAWLFWRKEEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS92</accession>
    <name>A0A1Q5SS92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hyaluronan synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS92"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS92"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="261"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="590" mass="66758" checksum="7E0B731B638A1C65" modified="2017-04-12" version="1">MDSFNEKNLYTGFSMFQQRGPDVSRFRQFLNLLGCIIVIPIYSYITGYTRHPLTLDILLTIFAAEYNRFSNENRRRRLKASTQAVQDVEKASYLLTGTERAIECMAAIVGYREDPKLFARALDSYKTAAECRFVLVGVDGDDTPDMEMVRVFQEVFPEKSAVIQIDEPLGEVAMKTFEKLSKVDGNAQAPKVYMEATIAHCCQLAREILAEHDLDLGEAGGITRLCLFQPHLHKKGIMFSAFIFSIVISEMLGIEYLWSSDSDTIIMTDSLRSTIETIAGDPHVGGGSSGLIIHNENDSVTTKLGSVVYWSELYMTRSTSTASGTSDCQSGPSTAFRITALPAVLYPWYTQTVLGHRMIVNEDRHLTTNLLMRGWTVTYVSDTLTATDTPTTLSRWIMQQVRWSRAGHIESFQQPQIYVLNNPLFFWAAIKREAGPLLGFGYILYYLITGRCFAYFNWYDVGIRVAYTLLYNFFRNPDRGPTNYWLWIGPGLLFYNIPLPMIHLWSLITVFQDGWGTSMRSTSELSKRGQAWKRWNDLGFFVVWMGIVGGTLARMFANMAGWDDTSIHQAIVLGVIVPSAVSFYGLVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSD1</accession>
    <name>A0A1Q5SSD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">26S proteasome regulatory subunit rpn11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSD1"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO90873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="335" mass="37304" checksum="8C35539EC8FEE5BB" modified="2017-04-12" version="1">MDRINRMLQAAQGIGMGGGAPGGDTPNLIDNSETVHISSLALLKMLRHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMEMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLIQPQTVVMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKTGLEENMLMSLHKHVWTEALQMNDFHEEGKHNVDQMKQLVSLAEGYEKRVKEETELTKEQLKTRYVGKVDPKKHIEDVSQQLIEDNIVAVSRQMIDKEASVARQSAAKDGGNDASMEVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ST07</accession>
    <name>A0A1Q5ST07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ST07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ST07"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="19347" checksum="E5591A580E84809B" modified="2017-04-12" version="1">MSLQLLALPPFGIGWPARCLYPLQACIRTPGAKPTTVDKSNNSIKYRHRDSGSANNAGDQNYTSGRGAESSSSGNRDDNDIPSDNNGGTPVSNSSRSQPPGDTDPKNLQSPQRSSNEPSDPLSLDTLSFTLFSQPFRTRFKFSIPSFSQHFDAQWPLKYITFGPYSPPHLERQARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUE7</accession>
    <name>A0A1Q5SUE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUE7"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="11">
        <location>
            <begin position="223"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO91638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="398" mass="43501" checksum="2DDCD2F0708E0F24" modified="2017-04-12" version="1">MNETTPSPSPAPGPKASPRSKPSPSPTAGTKRKRTTGNKLYAVKKGNKPGIYYSWPDCLAQITGFKGAIFQSFLTFEDATAFLSGANVPSANASAHGAENTRFYGVQRGRVPGVYTDWTKAQDQIRGFTRPRYRKFSTREEAEEFVNAGKEGAIASLEFGAPGMTTENPKDADGVEFVAGDGPLPQGAEDGFDPNVLLDPATGKMVYKTVAKKAATKTQAAGIPGMLRIYTDGSSLRNGTKLASAGVGVYFGPGDSRNVSEPLKGSRQTNQRAELTAILRAIDIAPRHRDVTIFTDSRYSIDCVTVWFVNWRRNNWMTKDNKPVENRDLIESILVKIEERNELKVKTLFQWIKGHNRDPGNEAADRLAVNGAHEGVRQKAEALEVSRRVPAAVFEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUF9</accession>
    <name>A0A1Q5SUF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUF9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="342" mass="38961" checksum="19B93588CA03493D" modified="2017-04-12" version="1">MGSRSTLHPRVVKHQLNSNLPAVMPDVQQEIEESIESQFPACDDWTEVNVVDCITQIVARVSSRMFGGQVLSRNKEWIDASIAFAVDGFHGAQKIKKYPEFLKPIAKFFIPEIMSIHKHYRMAEKAAIPLLKEREKTGEKALDLLYWMAEQAKGDEKDHKFLAGILLKVSFAAIHTSAAATSQLIYDLCAMPEYIQPTRRDQQLTFQRVITEDYVLSDGFVIPANTTIGVPTQGISMDPKIYNDPTKFDGFRFEKLRQDPEQNGKAQYAASNHSSMSFGYGRHACPGRFFAANEIKAIMAYLLQNYDMKFKEGQKRPESLLFETQYLPNMTATVMFKRRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV06</accession>
    <name>A0A1Q5SV06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">PENSUB_12930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SV06"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="401"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO91857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="811" mass="90678" checksum="EB731397FCEB24A8" modified="2017-04-12" version="1">MALLQYQAPVDYAAQLDGFKDFLQHFKTLQSTSEAAATEALEDLNIDGDRSSDEYDFMDDVDDEGADTRGARRRREPKLKYMQILQDIANRDVSNIVIELDDLDVFEKALPDEQQNLKLVDSIQKNTKRYIDVFSQAVDAVMPKETKEITFKDDVLDVIMSQREKRNETQEMQTEADMDVTPVASLFPPELTRRYTLNFKPLTPSGSSSDRAGKALAVRNVRGEHLGSLITVRGITTRVSDVKPAVQINAYTCDVCGCEVFQPITTKQFMPLSECLSEDCKKNNTKGQLFLSTRASKFVPFQEVKIQEMADQVPVGHIPRTMTVHCHGAQTRLLNPGDVVDIAGIFLPTPYTGFRAIRAGLLTDTYLEAQHITQHKKSYNEIGMDSRTMKKIEQHMNSGNMYEYLSRSIAPEIFGHLDVKKALLLLLIGGVTKEMGDGMHIRGDINICLMGDPGVAKSQLLRYITKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMMLEGGALVLADNGVCCIDEFDKMDDSDRTAIHEVMEQQTISISKAGINTTLNARTSILAAANPLYGRYNPRISPVENINLPAALLSRFDVMFLLLDSPSRETDEELANHVTYVHMHNKHPENEDSGVMFTPHEVRQYIAKARTYRPVVPTNVSDYMVGAYVAMRKRQKKDEARKQQFSHVTPRTLLGIVRLSQALARLRFSEEVVREDVDEALRLIEVSKASLYNDGESGADHTPSSKIYTLIRTLRESGAAAIGDDEDNALSVRRIRERVLAKGFTEDQLTTTLHEYAELNVWQIAGNGSRLVFFDGDDEMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZF0</accession>
    <name>A0A1Q5SZF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZF0"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="15774" checksum="B79ECBD68F4E4398" modified="2017-04-12" version="1">MIQPRMLSRADEATAGSEDNEVRREDQEKINRFSRLHQRETVLEEQLKAKQKDKEDLEEVSMELELADEDELVPYKIGDSFFQLPLADAQAMLETSTAQIDADVSKLEDSLGELREELQKLKVSLYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0S4</accession>
    <name>A0A1Q5T0S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0S4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0S4"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="24596" checksum="97C35CC02B3E684A" modified="2017-04-12" version="1">MWSWFGGAAAQKRKDAPKEAILGLRRQLDMLQKREKHVESLIAEQDAAARKHVATNKNAAKAALRRKHQHEKTLEQTSAQVMQLEQQIYSIEAANINHETLQAMKSAGDAMKTIHNGMTLEQVDNTMEILREQQMISQEIGDAITTMPLGETMDEGDLEAELEGLEQEAMDERMLNTGPTPVGTRLEGLPAAGNTELNKPHANEEEDEEAELAKLKAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0X0</accession>
    <name>A0A1Q5T0X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0X0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0X0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="10484" checksum="4D2084B7F8E27BC4" modified="2017-04-12" version="1">MLGDLFTESVLQSWNSMLTTLREHAHLSTYIPQCIATFETLSERILETRNPHVNNGVDSALDDYTAGLCFDDLFKDFDLDFNSFIFGIEDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Q6</accession>
    <name>A0A1Q5T2Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Q6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Q6"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="222" mass="24747" checksum="8FE19E4983514E0E" modified="2017-04-12" version="1">MPDVKMGNSATDAASNKPERLPITVSKPSPYTFDLGNLMVNDPNPVELPQGEPLNDSLKAIARDGAQVLLNQLLTTCTITSSAQNGVLLNLPAPATACPRHKPLPIPKPPTKWELFARKKGIGKFSQRPGFALADKERRKKLAYDEASGEWVPRWGYKGKNKPEDTQWAVEVKEEDWKKEEDAAAKGGNIRGMNRAERKDRIKRNERKERANERRSRKPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2R5</accession>
    <name>A0A1Q5T2R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2R5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="213" mass="22777" checksum="486E07C891B9390B" modified="2017-04-12" version="1">MTKTANLRLGGIAGWGGSQRCEDDTTIRADRSIHQDSPKEPNYLKPTISSRNRAHGSTNSQCYRDAEGSHWHSNATTPRPLRNPQLLSATGSRLRGYASCHGRLPPQLGGNVLTPDAGPHELHSNSAHSQAQQSQNSNIDPPKVEPEGASEGATLNGTTQENTTGISHDDPWVRSELPGITNGTTVNTPQPPAQNTHILDGEPSSGDKQSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2S6</accession>
    <name>A0A1Q5T2S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2S6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2S6"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="17"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="602" mass="68777" checksum="F9835E3D5C25F187" modified="2017-04-12" version="1">MDSHERREASGPFAQPKQFVLCFDGTGNKFAGDESDTNLVKIYRMLDRSQSHQYHYYQPGIGTYVTSHSLGSKGRIERIKSSYKKAKDAALGSSFDEHVLGGYKFLMRYYAPGDDICFFGFSRGSYTARFLAEMLDYIGLLQPGNEELVRFAWKTFAKWQQQKSGTERDDKERHKLFRFMKAFRETFSRPVSRIKFMGLFDTVNSVPMFENAWMERSKFPYTAQTTARVIRHAVSIDERRAKFRQDLISEVRPVAHGHLHSHRLRHLLSREDHEKTKVPEIVLPENDHDAGREGRRRPGSGNGTDEFRYRAPSSSPMRKGSSELPRTNAYLSEHHSVKSAIFRTSLRVPSLNIPGNGEEEQGEQDISEVWFPGQHGDVGGGWKLNPEDPWPLSHIPLVWMVKEAQAAGLEFDPEKLKRFNCYEEYPSTSEALKETIVPNSLAAHNQTNPHRQTDKFNEALTHTMNQGTAHDCLTYGGGLSFFSTLSWRIMEYLPFRRMDLQPDGTWKPIRWPLPCGEVRDIPEGAQIHISAVHKLRIDPNYRPGNLIVGGGGRGVKRAPEKYGIGEWEVCKHEGDLVRQTYIRKSSRIPAESICQDDHAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5W5</accession>
    <name>A0A1Q5T5W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reticulon-4-interacting protein 1-like protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5W5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5W5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="10"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="38326" checksum="C3E3519742ED00C6" modified="2017-04-12" version="1">MFSISITKYATPQNYELSELPAPTVEGPDDIVIKVHAASINPIDVKKASGASKAVLKDSFPYKIGYDCAGTVAEIGSQVTRFKVGDEVFARLPECHRGAWSELARTTEDFVALKPNSLSMEDSASIPLAAMTALQALRGYPGSLEGKTVFVPAGLSGTGLFACQLAKNVFRAGKVITTVSTSKVPQVKELLGDGVVDEIIDYRKTDPKTVIPAESVDFLFDTTGDSMNYLSLMRPTGAIVSIAILTSGDTLQNSSLMRLSPDKNNRATVPFAVKLALNVLDRIRTMRASRYGVKYSAIFLEPNAKDLGSIAEWVDAGKVRTVVGTKVPYKDLKAVRDACQVVYDSKGGVGKSVITFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Z8</accession>
    <name>A0A1Q5T6Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MNN4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Z8"/>
    <dbReference type="OrthoDB" id="5419802at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24568" checksum="77FD7DB80E465D10" modified="2017-04-12" version="1">MAGLQKDQLDSVISTLARKRGILNIDYAVMGGAAVCLLANDPTRITEDVDLVIHVDHRGVTADRLTSLLIDNFQSDFAPVLQFRHGIPGYKLSLPGGDVRLVDAEVFDYQSWPRQPQYNIPSSTRRSMIVNGQTVKTLSHEWIFREKTLSQHQREGSPKGLIDIRDINRMIPMLNPGKPELDFDRDIRLESALPNLLQKRPLLGARLKDLVKSNMVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8C1</accession>
    <name>A0A1Q5T8C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General negative regulator of transcription subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8C1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8C1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000007">
        <property type="entry name" value="Putative not2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="280"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="424" mass="46537" checksum="71D7C960ABFF5850" modified="2017-04-12" version="1">MGTMGSFAQSLGGSQPVTALDLSEFPSLSGASQQSQSQNPVWANASQRAAQHTPVQRQQHPPTSQPPSRASQTQQLPVQQPSQPPHDDMFPSGAQFANRLDDFRNGGQGISSQIGAGSQPQTGNIEEFPPLGRNVGNIGNVAAELAQERRTSLMQGAAFGTYNSGIGTSRSPVNQGPNGALGQDKEDLNNTLMSGQRNFSDPQQQLQQRQQQANEGQEASAAAQSAEQPPLAQMSELDRFGLSGLLRMIHSESPDVASLAVGQDLMTLGLDLNQPEPLHTSFASPFVSSMSAVPLEQDFSLPSCYNVANIQPLSSRIPGFSDETLFYIFYSMPRDIMQELVAEELMGRKWRYHKLERCWLTRDETYPGPVDVERGVSERGVYLLWDHTSWKKVRREFILRYEDLDNRLDNRTVNRAAVGQAHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8M1</accession>
    <name>A0A1Q5T8M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc transporter ZIP9-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8M1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8M1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO96582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="341" mass="35980" checksum="FE4C8166C4860FE7" modified="2017-04-12" version="1">MEGLFTLLALSIVMAVTSFVVGSLPLAFTLSPSQLRLISSIGMGVLVGTSLIVIIPEGIETLYSASSVSRKSFGARATNVDWSSQGLVSNQILNEDGDASSVPSSTPVSFLELDGERALPLVSRDAALEELHALNARKDETSSEKQKEEKEHQEEESSPHAWIGIALISGFILMYLVDKIPEFASPTKPDRQPYHISLDNLGSGLRRSSSPIRNGGLLDAGHSSSRRSHSFATTTGLVIHAAADGIALGASSTDTGLSFIIFLAIMVHKAPASFGLTSILLKQGLSSRTARAHLLVFSLAAPVGALATFLFAHMVGSSSGDQAGSQWRTGMLLLFSGGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8X3</accession>
    <name>A0A1Q5T8X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Niemann-Pick type C-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_10854</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8X3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8X3"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004765">
        <property type="entry name" value="NPC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00917">
        <property type="entry name" value="2A060601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012479792" evidence="16">
        <location>
            <begin position="26"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="743"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1172"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1213"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="17">
        <location>
            <begin position="594"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO96679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1273" mass="139750" checksum="0CCB7791F7F0C785" modified="2017-04-12" version="1">MRQLGLVGTLVGLGFLASQPALVGAQGETKIHEKGRCAIRGHCGKQSIFGGELPCPDNGRAHEPEDEVRQKLVGLCGSKWEEGPVCCLDEQIDALSSNLKLAEGIIASCPACRHNFFDIFCTFTCSPDQSLFVNVTQTEENRSGKRLVTEVENIWSEEYQSGFFDSCKSVKNGASGGKAIDFIGGGAKNYSQFLKFLGDKKFLGSPFQINYHTEPSGPDSEGMRALPMKPKACNDADKAYRCSCVDCPDVCPELPAVSTQASCHVGLLPCLSFAVIVIYSAFLTLVIGLASYVTYKERRFRKPERVRLLQDPTPSDDEDEGEVVHRGGYMEQPQGVYKPNSLLSALFRRIGGACARFPAITIVSSFIVVVVLSLGWLRFTIETDPVRLWVSPSSPAAQEKAFFDESFGPFFRAEQAFLVNETGPILDYDTLVWWFDVESRVRRMISLDKGLNLDDVCFKPTGDACVVQSLTGYFGGAVSNLDPDTWQDRLLHCTESPGDPSCLPDFSQPLKPEMILGGYESTGNVLDAKALVVTWVVNNFAQGTAEEANAIDWENSFKTVFDVVQEEAAERGLRVSFNAEVSLEQELNKSTNTDAKIVVISYVIMFVYASLALGSVTVTWRSLLMNPANALVQSKFTLGIAGILIVLMSVSASVGLFSAAGVKVTLIIAEVIPFLVLAVGVDNIFLIVHEFERVNFSYPDEEIDERVARAVGRIGPSVFLSALTETVAFSLGAFVGMPAVKNFAAYAAGAVFINAILQVTMFISVLALNQRRVESLRADCFPCVTVRKANSFGLPEEQIYDDHEAESTLQSFIRRIYAPFILDRRVKAVIVIVFLGILTAGLALIPEVALGLDQRIALPSDSYLISYFNDLDAYFRTGPPVYFVTRNVNVTERKHQQQLCGRFTTCEEFSLPFVLEQESKRPNVSYLAGSAASWIDDFFYWLNPQQDCCKEDDKQCFEGRNPPWNLTLYGMPTGPEFIHYAEKWIDAPTDASCPLGGKAPYSSAVLIDKKHTMINASHFRTSHTPLRSQDDFIQSYIAARRIADDISREHKIDVFPYSKFYIFFDQYVSIVQLTGTLLGSAVAIIFVLTSAILGSIATGAVITTVVVMTMVDIIGTMAIAGVSLNAVSLVNLVICVGISVEFCAHIARAFMFPPRTLLEKAPAKFRGKDARAWTALVNVGGSVFSGITVTKLLGVCVLAFTRSKIFEIYYFRVWLALVVFAATHALIFLPVALSYFGGGGYLDPAADGGLEANLASRGYRSLLVDDDYDSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAK6</accession>
    <name>A0A1Q5TAK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial acidic protein mam33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAK6"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="31737" checksum="0949ED8F5FA24C4C" modified="2017-04-12" version="1">MLSLRALTRSVPRFSRSIARTSLRPTTLAKPAIAQPWKQTIKPAYAAFSTASVFREPAGEGDVELIAKLEEELKHEKASGQEDAKEQQASIDYTLEAGQWQVKDVEGEQEVILTKTFGNETIRVTFTVADINNLAEDPMDELADDALADEGDYQNKPAEGEDEILPPTFPARINVTIEKPSSGALLVQAVIQDGDLQIEEISHFKNAEIANAETAEKDWSRQSFYAGPPAENLDPELLAFWGRYLEERGLNLEFQNMVTDYIAFKEQKEYVRWLDNVRKFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB83</accession>
    <name>A0A1Q5TB83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_10308</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB83"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB83"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO97514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="490" mass="53316" checksum="5A62F4726F83CCD6" modified="2017-04-12" version="1">MASKQPAKDFLSFVNASPTPFHAVQSAKDLLAKADFEEIKEKDSWAKTCKPGGKYFLTRNTTTLIAFAIGKQWQPGNSISMIGAHTDSPVLRVKPVSKKSGEGFIQVGVETYGGGIWHTWFDRDLGVAGRVMTRASDGSIVQKLVKVDRPILRIPTLAIHLDRQETFAFNKETQLFPIAGLVAAELNRTGESKPSGDAANDTEKVDDFSPLKAVTERHHSYFVELVASEAGVKPEDILDFELILFDTQKSCLGGMLEEFIFSPRLDNLNSSYCATVSLIDSVADESALDKESSIRLIALFDHEEIGSRTAQGADSNALPAIIRRLSVLPSSSSSDVDLATAYEQTLSTSFLVSADMAHSVNPNYAAKYESDHKPEMNKGPVIKINANARYATNSPGIVLLQEVARKAAAEKGEPIPLQLFVVRNDSSCGSTIGPMLSAALGARTLDLGNPQLSMHSIRETGGTYDVAYAIRLFTGFFQHYSELSKTIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCB1</accession>
    <name>A0A1Q5TCB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCB1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="222" mass="24856" checksum="D608F878793853F2" modified="2017-04-12" version="1">MAPFGTIYSYMPSPRVMKAQAAANINGLELAIYPEFAMGKTNKTEDFLSKFPLGKVPAFEAADGTTLFESDAIAQYICESGPAATQLIGGTPAERAAIRQWICFAQGEILDPVTQLALWRLKIRPYDEATETNNLQRLERSLRCLETHLKGRTWFASEDKVSMADITVASALVWGFSMVIDAEMREKFPLVIGWYERLIQVDGVKEAFGEKNFVEKRQPYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCL7</accession>
    <name>A0A1Q5TCL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Myo-inositol transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="150" mass="16462" checksum="2B96D5D8980BD318" modified="2017-04-12" version="1">MAIYMMVAAAVTFSYIPVNTSTLELETDQVGWPGPVVLVAIIGYVACFSSGVATIAWIGTELIPLEVRALGTMLNTVTCWSTNIIIASTFLSMMKNWTPSGAFGFYTGMCFVGWLFVIFFYPECKGMPLEAVREVISHGFGVGYSKKWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD84</accession>
    <name>A0A1Q5TD84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9282</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD84"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD84"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="108"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="32771" checksum="D278ED91ABA38646" modified="2017-04-12" version="1">MASARSLMRLSSGRSVASAARSNATRAFSSSSLRYAAKASTQPGAPEPENMRQAQRPPSGPLRAPIVNPTDKYQHMADGLHSYGQYIMSCLPKYIQQFTVWKDELTVYTAPAGVVPVMSFLKNHTSAEFTQISDITGVDFPTRDQRFEVVYNLLSVRYNSRIRVKTYADEATPVPSVTGLFEGALWYEREVYDMFGVFFSGHPDLRRIMTDYGFDGHPLRKDFPLTGYTELRYDEEKKRIVIEPLELTQAFRNFESGSTAWEPVGSGQNRTPESFKLPTPKPEPKEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDH9</accession>
    <name>A0A1Q5TDH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDH9"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270856" description="TNT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TNT" evidence="2">
        <location>
            <begin position="125"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="241" mass="26447" checksum="BB8A9342B7362328" modified="2017-04-12" version="1">MRIAIFTLFGVALADTSSYVLLKHTNGNTESDYPARCYPDPCKGITFQNKTAVCGDPRLGPIKLPQYFPLSTEVATYHRFGDLCPYEFLAKYSLNVSDPNAYLIYPGANGFANTTNQTAISGIATLEVGRKVDRFGDPTGTFLAPLGAPYIERGLPPKNLFAPENSSFPYNYHVYQVMEPITVALGPVAGWFEQPGLGTQFVLQGNQTVASLVDSHKLKVLEKREYDEAADFAADYLPSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEI3</accession>
    <name>A0A1Q5TEI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="51" mass="5651" checksum="E6CEA5AA767B4F30" modified="2017-04-12" version="1">MGMGGGSREWREEEGASINQIHQEHTAAVAGEWMCLEVEGQLERSDPPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF59</accession>
    <name>A0A1Q5TF59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_8742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Integral membrane transporter that imports quinic acid to be catabolized as a carbon source.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF59"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="22"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO98825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="56630" checksum="944289935F54A941" modified="2017-04-12" version="1">MANSSSDMAHNAKPNAMRVYLLAIVTSMGAFMFGYDLAFIGTSIDLHSFKKDFGLIGATQSVQDAFSANIVSLLQAGCFFGALAAAPLGDRLGRRIALALGAISFIVGSIMQVASAGSKPLMFVGRVLGGMGVGAASMLVPLYTAECAPPQIRGRLVGIYEIGVQVGTCMGFWINFGVEQHMAPTSAQWMTPFALQLIPGGLLLIGLWFMPESPRWMAKAHGRAQVTEVLSLLRNLPGDHPDVQHEVEDILQQLELERVMSPDGTLSSVKELMQPGIRYRVFLGVVIMIFFQMAGSNAINYYSPRIFRSIGLTGTKTTLVSTGIYGIVRLVAVFFAMYFVVDRFGRKPMLIIGSIVMALSMWLIGAFVKVQSAEVKTGESISGTSYAAAVFIYLFAVSFCFSWAGVPWIICSEIYPLQVRGLAVSICVATHWLFNFVIARSVPYMISNIHFGTYFVFAACTTLAVPFVWFMIPETKGLPLEEVDLLFEDRIFSLRQRGSSSRHEVSDQKVAVEQIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF75</accession>
    <name>A0A1Q5TF75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_8804</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF75"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="103"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="296"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="530"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="682"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO98887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="876" mass="91144" checksum="B30F86C844E2C98A" modified="2017-04-12" version="1">MSEVQSRSSARGRVSTRGGRGGYSSRGGRGGNSRAANTDNPDLAPFDEGEIGQMKKKYSDALPTLKELFPDWKDEDLVFALEDSNGEIEEAIERITEGNVSQWGEVKKKTTDRTRPKPKDVQSTPTDIAAASARGGRGRGGFEGRGRARGDRGRGGRGGRAGAQVTNGSRPAEVSASTVAPVAEPSTAAWGEVESEPTVAASEPTDPKTSVIPEGTKKGWASLFAKPPPPPPQPKKAPEPAPAPAPEEPEEPVVEQQKAPEPAPAPVPVPVPVPAAAQKTPVAKPAEVTIPVIPQTTVKAPKDDLTETNLEQIPDVSAPAPTATAASTVGSAFDPAAAAAATPSRAPPSALPGSGLKQSSRAPGFQRRVMEQQQAVVMPGNHAVDRAAVQFGSMGLNGDAVDIDENREEAETRAQPPQHSPVAPRASLPPVTQGAGETRPAPGLPPVPQASAETFNDFARYSSETQKPFDPFTQQVGQPQPQIQEPFANQAPAQPTATTGSEYSPFYAVDQQRFPYNYYGSYGQSQDANAGPRGAGFGGVSAAEAQPQIPTTQPAGRYGPVDATNSGHNTPNPTLPGATQTPAAQHMPGQQSAHGYGYGYPYYSNPHYASYMNQMGQHAGAAYGRSGRPYDDARRYDEQQHYGMPHTSQYGYGNQYGPYAGAAAGAKGGMYGQPHGFSYDHSSSPANAAASSFNQTAPGRDSVYGRTGSAQPSDTQQTAAGSNAFSSGMSDVFGRSQAGFGQNPPVAGQPPVTAEESKGFDASKTGGPSPSLAQANRPGSATNTPGQAQTQSGLPPLQGQQGQQGFSGYPHLNPQYGGLGGLGGHQGAASQTHQQQQQQQQQQQQTGYGNYGAGFGNYYGNNTGRGNGGWGGNYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGE2</accession>
    <name>A0A1Q5TGE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TOXD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGE2"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="32"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="366" mass="39462" checksum="8A42950162FD21B5" modified="2017-04-12" version="1">MAAQVPSSMKALVADRSIVTRLSNYSCGHSSGDGVKIQTTPVPEILDNEILVRVRSVALNPTDFKHIDVVAPRGAIIGCDYSGTVAMVGAKAPGYWQVGDRVAGFIHGGLYTDRGSFAEYLKIPGDLAWKVPPSVTDEEAATFGVSAVTAMLALNARLGVPWLDSGKSEGRTDTPIFIYSGSTAAGLYSIQLAKLAGLKVVTTASPKSYDLVKEYGADDVFDYRSPTAVQDIIRAYPNVDRALDCFSEGKSTEFCADVVRRSRGWVVTLLDSGKKEMNGVRIDFMLGYTVFNAEFQWLPPLGPKFPKVPSDNEALRRFYAALPEIALKLKTPPLKKIDGGLENLTTGLNMLRQGKVSGGKLVATIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGY2</accession>
    <name>A0A1Q5TGY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000657">
        <property type="protein sequence ID" value="OKO99461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGY2"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="318" mass="36585" checksum="398383C71D4885E9" modified="2017-04-12" version="1">MREAVKMPSSAEKTFSIYEITEHILLHLNDHVEIIRVQRVCRAWKDVIQTSPALQSACWYQPSNDRNSQKRSISDQQTQSWRLNPAFNQIGVSISEDSIKGVHLADNIQEKGDFSLQKRIYDKPGSWTTMLATQPPCQRISVECYGNYSGDETIHYLIESTTGCFLMGDIMAVLAECQNRQECGIDRWAGVRHYTGRLLRWSESYWDDNADWKMHAQMSNDVSVKVAVTIPWGGPECPAFSLRRLHGSKVFLHEMILHKMITDDDSEYQWDYWYHGGSLGKPVCQTEPYKANLLVVQQLQEGYLSNCSHIFRLLSDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH89</accession>
    <name>A0A1Q5TH89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH89"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="13">
        <location>
            <begin position="54"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="280" mass="32502" checksum="B7921C3FF90230BF" modified="2017-04-12" version="1">MATSMMHYFGFGNNAPPSAKDEVKNEHVRALPASWYTSPEMYELERRAIFSKRWIFLTHSSRVKEAGDWLRYEMAGFDFIITRDRQGDINAFHNICRHRAYPVVEKQGSGNSKILSCRYHGWSYGLNGKLAKATGFKDVDSIDKDQNSLFRIHVKVDVNGFIWVNLDAKEVPEVSWEDHFRDVDKQDRYKAYNFDNYDLDHTYELEGHYNWKILADNFNECYHCPTTHADIPEFLNLDSFDSDLKGGHIQHHCVSTPEQIAKGLYTASTYYFPVTAMVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THG6</accession>
    <name>A0A1Q5THG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THG6"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="295" mass="33163" checksum="7672EE45A166ACDF" modified="2017-04-12" version="1">MVNTKTIRVSHLGGIDVAYQVPREYDPAKPTVVLINAFTTSSELYRDQFNDASLTDKMNLVAIELLGHGQTRTAREHWTYWDTAEMNLQVLDALKIDRAFVLGTSQGGWVTVQMALLRPEKILGIIPMGTSMDCESERTRQLDCWNGPAIVSRFLKQWASSEATPNFEPDDVYCDAVIGIGLNQVTPEVHEFWRKTIKSNYQGDEGRRRIRMAAINLGERGALHFRLSDIQCPVLWLHGTKDAVYTIANAREEIQLFTRSPSATLVPVEGGAHFLNASHPREVNAALLDFVNQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIJ6</accession>
    <name>A0A1Q5TIJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylic acid transporter protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIJ6"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="500" mass="55048" checksum="4098166C1329FC46" modified="2017-04-12" version="1">MADTYDQSAHAQNSPDVEEHMSVGRYIATRIPSLVPPMNPAPNPFKALTLLNRQQWMFFAVAFCGWTWDAFDFFTVSLTTSQLAKTFDKSITDITWGITLVLMLRSIGAIIFGIASDRYGRKWPFVVNQLLFVVIELGGGFCQTYKQFLACRAIFGIAMGGLYGNAAATALEDCPPEARGIISGLLQQGYAFGYLLATAFARGLVDTTSHGWRPLYWFAACPPLLIIAFRLCLPETETFRRRQEARAEMRGGVAASFMSEGKVALKRHWLLLIYLVLLMAGFNFMSHGSQDLYPTMLSNQFNLSKNGVTITQVVANLGALSGGTLCGWASQIFGRRFSIIIICIVGGALLYPYTFIKNESVMAAAFFEQFMVQGAWGVIPIHLMELSPGSIRTFVVGTSYQLGNLVSSASSTIESTIGEQFPLPPTKAAPHRYEYGKVICIFMGCVFAYVILLTIAGPERLGRNFDADHDADLAVVAAQRGMNRDGYESDPEKATATQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJS2</accession>
    <name>A0A1Q5TJS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJS2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJS2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="653" mass="73345" checksum="A4E74EA9C9ECC7E4" modified="2017-04-12" version="1">MQKTRKRPRSSPEADYTTPACNQCRSRKVRLHDFSSVLNRLDDVDRSLARLSQQVGSLTAKCTAAGSLPLPITINDQNSLAMEREERPAQLEVTSNRALLNEGHSERLYGYPAALCLFRASQKLLGATLNANPSSLRGPLVKIMESPALRTSLRRHYEMFPFRKACTEQPISGDQEPITSPPQFFIYSVLDRYLNHINLYIPVFGAGTLYDTVADCYRPDGPPSQAGWLVCLNCIVLLTLHLDACVARRSGLGMDPWSTQSEVINNALNNCRRALANLDALLQPGVVNIQALIMLALVAREFFISAVFENVCSAACKLARSMGLHRCVGMANDSVLEARQRLFWILYVMDKTRVFLSGHSPDLHLFDSEFQLRLSDSQMSVASDFHCVMAHMMTVWEEIYIGLYSARAVRLGAEYRHSQVDRLDRMCDECQPLIPLQESSDPGLRLMQLEVRYCFHVSKILIHRCHRMTGGWQRCHEHAVSALQIITDVFEQPATPGSCVILGRIFQNYPLVAFHDLCLRYLTEGLVDVAAMLPRLINVRRQLSSLEHKGLPSAYFTKLNLGVTWCTDLMSVVNNSSKALEPTTCLLTPSTSTDMGDLLPSMSLRDENANYWADTSDTLIQDQSDILGTFGSPDYFFDPTFFEALLPEEHFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJU1</accession>
    <name>A0A1Q5TJU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="402"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="568" mass="55665" checksum="F0C95ABA3BFFFB72" modified="2017-04-12" version="1">MDNCQFHIIEKIVDALMASKNRAETTQFQCDEGKSGTPGFTISPASQLQFHGSEYFIACETGQNGGKNIYTTNSTSVTKCKSVILTADSCINAGSPPIVGTSPAPGKNVTGGGAAAPGAPGASGVGAPGAPGAPAPAPTVTVISTITVSNCVCSTTAGPAASVAAGAPAAAPSQVSSAPGSAAPSHAASSASSQTSAAPAATAPAAVPVAPAPGHTSVTSGATGTAPAPTGAPAATGAPASSLSTHTSAATVIPVPVAPAPGQSSATSAGIASPAASSQTSAATTAHPTTPCPSCQSATSSATQGTGTASPGPSCQSASSSSNHTCPSCSASGTNVTTTASGPFSSVTGFANVTNISSAPVTSLSTSIHPSSSVHANSTSTTATATSTSATGCPTDLSGEFQFPHLIVRIDSAKPDTPHGTGLNGTVNSTVATTFNFDIPQSFSGKTCNLVFLFPRKEELQTTSFSFSGDGKVAFGKLSSTVTTSTTENNVPSVSQGLGTSAISPGHSFLISTFSCPAGQAIAFEMKSAGSTDFEFFEDWNPSPGKMDNILHSYCGHFSKSQWKNHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK43</accession>
    <name>A0A1Q5TK43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7740</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK43"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TK43"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048508">
        <property type="entry name" value="LDL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21691">
        <property type="entry name" value="LDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP00595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="25779" checksum="6EBEB20178E548E2" modified="2017-04-12" version="1">MSANHRAQSHTSPYGLKRIYLLIYNTVCAALWLQILVTVILTLVSSPDVSDVYTSVEPWTRFTQTLAVAEIIHAACVFARSTQVWAVNHAFPEMTSTSRAYGAMLLAWSTADVIRYSYFATMLAGLENSTVLKWLSLRVSNPNVLDIYGAGSSLVAHELTAQRGAKTCLNDNDLLTARSPYYGQNGWGGTITGSNIPTQQLCWDSTLDIINQCLGHKNGGSYSQNGWNVSTDFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLB3</accession>
    <name>A0A1Q5TLB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Conidial yellow pigment biosynthesis polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_7597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TLB3"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF45">
        <property type="entry name" value="CONIDIAL PIGMENT POLYKETIDE SYNTHASE ALB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="373"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1293"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1641"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1761"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1452"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1606"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1718"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1606"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1718"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1746"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP01016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2139" mass="233777" checksum="DBA704A17D99DC26" modified="2017-04-12" version="1">MESPSRVYLFGDQTADFDSGLRRLLQAKNDSLLSAFFQKCYHALRKEISQLSQSQRQMFPRFTSIVDLLARYREFGPNPALESALTTIYQLGCFIHYYGDLGHQYPSKSESLIVGLCTGQLASAAVSSSKTLGELIPAGVETVVLALRLGACVVKVRELLEENGPSQSWSVLVSGIREEEAQKLIENFARANALPRVSQPYISAVSPNGLTISGAPSILSQFIETSLSKESKPVRVPIHGPYHAMHLYDDRDINRILESWPKEKFVNYVPQIPVLSNESGKPFKAESLESMLRLSLEEILLHQLCWDKAIDSCASALKSATSKCTLFPVSSTATQSLHSSLKKAGISNLEIDSTIGDVKKDPESANSTGRADQSKIAIIGLSGRFPEAQDTEAFWDLLYKGLDVHREVPAERWDVKAHVDMEGNTRNTSKVQYGCWINEPGLFDPRFFNMSPREALQADPAQRLALLTAYEAFEMAGFIPDSTPSTQKNRVGVFYGMTSDDYREINSGQDIDTYFIPGGNRAFTPGRINYYFKFSGPSVSVDTACSSSLAAIHVACNSLWRNECDSAVAGGVNILTNPDNHAGLDRGHFLSRTGNCNTFDDGADGYCRADGIGSIVLKRLEDAQADNDPIYGVIAGAYTNHSAEAVSITRPHAGAQAFIFDKLLNENDYDPKEVSYIEMHGTGTQAGDAVEMKSVLDVFAPDYRRGPNQSLHLGSAKSNIGHGESASGVSALVKVLMMMQKNMIPPHCGIKSKINHNFPTDLAQRNVHIALKPTPWNRPAGGKRKTFINNFSAAGGNTALLMEDGPLRERTGKDPRSVYPVAVSARSQSALKSNIASLVQYIDKNKSLFNVNESNLLGDLSYTTTARRIHHPFRVTATGSTLEEIRNALNSSASRDSFAPVSAVAPGIGFVFTGQGAQYAGMGKELYEHNSQFRANIEHLDRIGQSQGFPSIMTLVDGSVPIEDLSPVVTQLGTTCLQMALTKFWISLGVTPTFVLGHSLGEYAALNASGILTTSDTIYLAGRRAQLLTEQCKVGTHAMLAVKSSVAQVKQFLEDDAAEVACINAPSETVISGAVDKIDQLAEKLSNEGFKATKLKVPFAFHSAQVEPILNSLAGIAKGVVFREPTIPFVSALLGDVIDGANTEVIGPSYLTRHCRETVNFLAALEATRHAKLMNDKTLWVEIGSHPVCSGMVKSTFGPQATTVTSLRRQEDTWKVLSNSLSALYLAGIDLRWKEYHQDFSTMHEVLSLPAYKWDLKNYWIPYTNNFCLLKGAPATAAVEAAPATTFLTSSAQKVLETSGDQTSATVVIENDIADPELNRVIQGHKVNGAALCPSSLYADIAQTLAEFLVKKYKPEWKDRGFNVCDVVVPKPLIAKGGKQLFRVSATANWAEESAKMQVWSVTLEGKKMIDHASCTIKFFDTSVAELEWKRSAYLIKRSIEHLKESTETGQAHRMKRGMVYKLFSALVEYDENYKSIQEVILDSDQHEATALVKFQAPPGNYHRNPFWIDSIGHLSGFIMNASDATDSKNLVYVNHGWDSMRCLKKFDPNVTYRTYVRMQPWQNSIYAGDVYLFDGDDIVAVYGGVQFQALSRKILDTALPPAGGSAAKPAAAAKPKPAPIDVEKSRAPRPKKSAVSSTKSAGPSIITKALNILAEEVGLSTADITDDLNFTDYGVDSLLSLTVTGRYREEMGLDLDSNVFIDQPTIKDFKQLLVQMSPQDSSNDGSSSEPDLSSAASSTDLSTPNSSGLPTPANEKSMTLGQNDSMKQICAILAEEIGVEPQELRGDSNLGEMGLDSLMSLTVLGKIRETLDLELSGEFFIENQTIEEVEVALDLKPKAIASEPIRLPEEIQVQAPKVARSSIQHPPATSILLQGNPKTATQKLFLFPDGSGSATSYATIPGISPDVCVYGLNCPYMRTPEKLNFSLDELTYPYVAEIRRRQPTGPYNFGGWSAGGICAYDAARHLIFEEGERVERLLLLDSPFPIGLEKLPRRLYRFFDSIGLFGEGKAPPPKWLLPHFLAFIDSLDAYKASPFPFDDIKHAEKIPKTFLVWAKDGVCNKPGDPRPAPAEDGSPDPREMQWLLNNRTNLGPNGWDTLVGSKNVGGITVMEGANHFTMTQGEKAKELAAFIAGAMKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLE4</accession>
    <name>A0A1Q5TLE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13118" checksum="5775A53F2E067C34" modified="2017-04-12" version="1">MGTDVTEAHHLGAERASRAVVPLEDALLIGVGIAGAKTAVALMCQDQVVRDPPSGIEIFVRPLTDGRDHLPTTTVTEILDIGLGLGLYLDTLHDLWHRRHPLIPPTLEGTRACIQTDLSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TML9</accession>
    <name>A0A1Q5TML9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-reducing end beta-L-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TML9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TML9"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049174">
        <property type="entry name" value="Beta-AFase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049049">
        <property type="entry name" value="Beta-AFase-like_GH127_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43465:SF2">
        <property type="entry name" value="DUF1680 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08910)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20737">
        <property type="entry name" value="Glyco_hydro127C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="1">
        <location>
            <begin position="16"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="446"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 C-terminal" evidence="3">
        <location>
            <begin position="557"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP01454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="662" mass="75528" checksum="4BA2E177DDEAEB7B" modified="2017-04-12" version="1">MEYPQESFAATTFTTGSFWARRREVVRKQTLRHQLKMLKDTGRYDAFKLKWHPSYSDPPTVYPVPNHQFWDSDVAKWIEGACYLLMDSFDSEIDAAVKEMVQMIQGAQQADGYLNIHYTVVEPGKRFTNLRDMHELYNAGHLIEAALAHHLYYKNDELLSPILKYVDLFVATFGDQDGQLLGYPGHPEIELALLRLYKVTGNPEHLKLAKFFIEERGNHQGGKGKRHYYDVEAEARGENEHELPTCYPAARSYWYQQAHKPIAEQETIEGHSVRAMYLLTAVADLVRIHQPTSETGAKFLPALHRLWSNMIEQKSYVTGGIGAIKKWEGFGIDYFLPHGTDEGGCYAETCAAIGVMMLAERLLRLELNSQYADIMELCMYNAVLTGMSLDGKAFTYVNHLASSNEDLSERYEWFECACCPPNVTRTLGFLGGYFWTHTTSHKRAVVNVHMYTSATLNLKVSDSTVTVTQKTEWPWNGDVEFETCTDGPPVELELRLRIPSWATSWEIAPRPDNLKIANGYLHLSAEWLREHSKFRLSCPMKPRFVRPNPLTMQPVAYVTRGPIVYCVEDVDHPWEQQHFKRTILDLNASLKEELRSEPDSYIAIVAENGSKGELDTSAWDGQIVAEPKDEVSNGSKNLTFIPYYLRANRGGRGQMRVGLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP34</accession>
    <name>A0A1Q5TP34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_7204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP34"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000014">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="10">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="21578" checksum="4C69A18DC761FD90" modified="2017-04-12" version="1">MAEVADSGPVEPQARHIVYCGVCTLPPEYCEFGGTAKKCEEWLKDHHDDLWSQLYADDALNANLSTLSVSAQERAAKDAAKKEAKAAQNEARDAERKAASKIQIKRVERNKRKYVTVIIGLEIFGLENKKLAKELGKKFATGSSVTRSPAGTEEITVQGDVSEDVKEWLLEIYGSKVPESNIELIEDKKKKKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU83</accession>
    <name>A0A1Q5TU83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU83"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7887" checksum="20058FB9F65E557A" modified="2017-04-12" version="1">MVKLLIGHGADVNVQDEQEKSALLHAARVGDVSLILTLLDCGAAIDHADRLRYTPLLLCQLYKTGLRYSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXJ4</accession>
    <name>A0A1Q5TXJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP04957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="5874" checksum="0EBDF1F0D24F4BFE" modified="2017-04-12" version="1">MLLFRQINISPASERSGEAEGNGHLEFEAPQASRGRWISCRISRRNGRASGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U028</accession>
    <name>A0A1Q5U028_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U028"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U028"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="227" mass="24775" checksum="B8DECD7E26E4D292" modified="2017-04-12" version="1">MLRASKGVGPAPGASGGPLKNLPSNRERVLNANHAAHDLLKELGRGQNTTRPAPKVVSFLRQVEDLTKDLLSTPLTDWQQELEALRRDLKQEITLTIKAAAEPPARQTVRSFAEMVRTMPTPAHYLSSSSLSSSPTRPAEVARNREVVVCLSDRSQVSVFRCLTSAELTKRTNQARAKAARTTDTAPLASGVIVYDVNVRSLSINKASEALLQERIIKDLLAANNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0C3</accession>
    <name>A0A1Q5U0C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0C3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0C3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP05929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="15064" checksum="1C6712263C2551BA" modified="2017-04-12" version="1">MGAHSATWQAYVDSRYFDLPFLMQLLLMGSGQFDKAGVLAADFSGLEAASPGFTLSQEDINSLASAFTSSANAFANGFSVGGEKFVCIKADERSLYGKKGKEGVIIVRATACTMIAHHGEGTQTTNAATVVENLIDYINNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0G9</accession>
    <name>A0A1Q5U0G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_6689</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0G9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0G9"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="105"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP05969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="55094" checksum="5EE2FD32C05DBCB5" modified="2017-04-12" version="1">MSQRLTGAAVAEHNSKDSCWVIVHGKAYDVTEFLPEHPGGQKIILKYAGKDATEEFDPIHPPDTLDKYLDKSKHLGEVDMSTVEQEEKAFDPEEADRLERVKRMPSLAACYNLMDFEAVARQVMKKTAWAYYSSGADDEITLRENHHAFHKIWFRPRVLVDVENVDISTTMLGTPCSIPFYVTATALGKLGHPEGEVVLTKAAHKHDVIQMIPTLASCSFDEIVDAKQGDQVQWLQLYVNKDREITRKIVEHAEARGCKGLFITVDAPQLGRREKDMRSKFSDPGSNVQSGDDGIDRSQGAARAISSFIDPALSWKDIPWFKSITKMPIVLKGVQCVEDVLRAVEAGVEGVVLSNHGGRQLETARSGIEVLAEVMPALRERGWEKRIEVYVDGGVRRATDILKALCLGAKGVGIGRPFLFAMSAYGVDGVNRAMQLLKDEMEMNMRLIGATRIEELNPSLLDTRGLLGGHAGAIPSDTLGLGVYDPLEAPRFNEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0Q6</accession>
    <name>A0A1Q5U0Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0Q6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0Q6"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="34146" checksum="9470DA12E2BFE482" modified="2017-04-12" version="1">MVQQTSFALITGCRSGIGTQLAICFAARGVTVLATARCVDHLQELTSQYKNIEAFPLELGDAGSIERLRDAVAIRTGGHLDFLVNNAGTHYAATAMDLELEEAVKVFQVNVFSVMRLCQLFIPLLRRSHRGRIVQIGSVTRDVPVVWQCAYNASKAALSQYTKTLRLELAPFNIDVIEIVTGFVRSNILHHGLVAPEGSFYLPIKEIIETMKYQGNKNGMETGTYARSVVEKLMSKRTHSEIWEGNMAWTIRFLVGFLPLWLLNWLYYRKFQLGRLRCAQKQRKGSATAHSTPDPDSRAKFSGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1S2</accession>
    <name>A0A1Q5U1S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1S2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1S2"/>
    <dbReference type="OrthoDB" id="3913483at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="15140" checksum="F26DF76D9E0A6E4F" modified="2017-04-12" version="1">MSEQTFRTTRQDLRKDESRIAQQHGGKTPSDSNVSQMKSMIDQNTDKPKQIDEAKANLPLPDQPPVASDWNSSDQRTVNVGSGGIEGPISGDNDTALRGPATGGSSARIDGAEMHKTTVPGGNVGRQRVEGLDNLPSDATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2J5</accession>
    <name>A0A1Q5U2J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000590">
        <property type="protein sequence ID" value="OKP06702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2J5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13607" checksum="F2DA949F049AECAA" modified="2017-04-12" version="1" fragment="single">PLILDHVRVPSLTMAQYDRKAAERRCNKLFEDYKKWVDSLGGETYSLDSAGSSKPAGSSKPTRSSRTKLGSTPTEHGRASSPAAKPESRRNRRVRFEPIERSQSPEPTQFSRNDQAQSVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3W3</accession>
    <name>A0A1Q5U3W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U3W3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22976" checksum="774DBF96E57667F7" modified="2017-04-12" version="1">MSSYFSAMLEGPILETQHSVFXLQKVEGVVSDQSLEALIQWLYLRAVVFAVDDPTEQISAAIELARLADMCRISGLAAPMAEYIQKVVLSNPSPESDPYWRHADTNTHYITSQHIASACTLPPKHPVRHVLAKASVEGYLRQQDYKFFEETQLYPSFGADLLAEVSMALGGLISNSNVAFEDPISGVRVELNTRKSIQWGTADNGMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4E0</accession>
    <name>A0A1Q5U4E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_5925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4E0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4E0"/>
    <dbReference type="OrthoDB" id="4379436at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="11">
        <location>
            <begin position="286"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP07336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="437" mass="48355" checksum="B020586A413B333E" modified="2017-04-12" version="1">MTTSTFDIDDKFKYLNGFNGYHQSEAAEGAIPSVINIPQKAKYGLYTERISGSSFTAPRKDSKQTWLYRLLPSTCHEEFSLLGNHPFNVNNVLNSKYQYSPNRSTWVPVQIAKEADFLIGLQLIGGAGNPTMKEGLAYYAFTAGKLMPPNQAFYSADGDFLLAPQKGTLDIHTEMGYLRVRSNEICVVPRGIRFQVSLPAGPVRGIALELFEGHFELPELGPIGSTGLANIRDFEIPTASFDNSDVDTEIIAKFAGQLHRAMHRGSIFNVAGWSGTYYPFKYDLGKFNTIGSVSYDHTDPSIFTVLTAPSSVPGEAVVDVAVFGPRWLVMEKSYRPPYFHRNTMSEFAFVIKGGFDVTPLPPQLEGLFLLSNTMCAHGADPESWKQATEKELVPEKIPPGNLGMMFESKYIIGLTETANKKFVKLPGNSAEFEKAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4I4</accession>
    <name>A0A1Q5U4I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4I4"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35724" checksum="D6EA4174DB715AC7" modified="2017-04-12" version="1">MTTGDVGILKSTLLPSFGLYSGLSITAYAAAQATDRLEIKDWLWPSAQVLNAWLTAIGRPMYETGITFPDAWRGLTWSEKLLLSGVTIWGTRLFARIVSRSLARGKDDPRYEAQKKEPGFWKTALFKIFLPEAAFLSFISLPITVPYSMGDTTLSVSTNTLSTVRALAVGLFSSGFALEVMADTQLELHRKEREDLCRHGVWSLVRHPNYLGDTLVHLSFLFMNITDSFNPIVLLGPLANYVFLRLVGGDKVTEESQEKRYREQNPHKYEQLRSWRGEKNSFWPSLRDLTNPWALAVVGCGLIGVVAEEVVRSSLTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4I8</accession>
    <name>A0A1Q5U4I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4I8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4I8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="30372" checksum="0EEFEDF52647D35A" modified="2017-04-12" version="1">MSNFMHKVKEAVTDHHEKDDVPTNEPAGTHHTYRSTNPYNKDPVAAQQNPSMMNAESGAGTGRGSGNHGAARGPDTYDTTTTGANTINAGPHNSKVANKLDPSVDSDLGHLQDHRAQHPGTRGATGTQNVGAAPQTTNTGNMAPGRENMAPSEQPRAFGTDTHTSNEDKYNKATQEHKAHKQPGVPGSGNQMSSEDSYSSSTQENKAHSTTSHTTPCQMKPTAEEPGPQGRATQPEFGGSAAGGSSYAQPPVREQAGMQNTNRTGKVDPQAQGMGYQQSDIGNQRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U6Y0</accession>
    <name>A0A1Q5U6Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U6Y0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U6Y0"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP08245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="705" mass="75198" checksum="A5EF1226FE8F469A" modified="2017-04-12" version="1">MEGKSPLYEAACSGNLDLVNTLIESGADVQETNDHGWTPINAASDEGHIEVVKLLLEHGANAKKQSDTGWTSVHSASDSGHAGIVRLLLEHDVDITIPNVEGSTPVHSASAFGHIEVVKLLLEHGADITVADERGWLPIHAASGGNHVDVVKLLLENDADLTSQTQGGDPPLSVASHEGNIHVVKLLLEHGANAMIPDKDGWTPVHLASGNGHLEVVSLLLENGATATLPINDGRTPILMAVAGGHIDVVKLLHDHDGDFATQANSGFTPLSMSVYDGNTQLVRLLLEWGADPNTPRIHGSTPLSIASFNGYMEVARLLLDHGADHTIPNENGRTPLCFASDMGHIEVVKLLLERGADPTVRIDDGSTPLLLAVIDGYTEIARLLLDKGADTDVPGPLGITPLGMAACEGYIKIVQLLLDQEADIAAVDEDGSTALHAASRKGHTDVVRLLLEHGADVRLADKRTKSTPIHLASFGGFVDVVKLLFNEGADITAVADDGSTPLHYAAFNGKVEAARLLLEVSSEGLDTGDLYARTPLFWATACGHDGVAELLLSHGSSVDARDHYGATPLLVAVRNGNEKVVKRLISLSKVDVNSKDVLGRTLLEWASKSGKPEIVQIVREQAGISHEDDSEIKLDDSSVLNDFQTGYDWLCDVCTRASLGKESSYQCVKCADFTIDVCVECFEAGARCLNLSHELTLHRRDEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U829</accession>
    <name>A0A1Q5U829_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HC-toxin efflux carrier TOXA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U829"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP08611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="39485" checksum="2C8F031EB0CB8183" modified="2017-04-12" version="1">MSQTSSSRPPSEKPDIDKMAASQDEKQIEDGEKGVGSPDEGPQEHPKGFALAMVIVALVLSVFLVALDMTIIATAIPRITDQFHSFDQIGWYGSAFFVTLAAFQSVWGKAYRYFPLKTGFVVAISIFELGSLLCAKPVDATWKEKILQMDFPGTAIILAGMICYLLAMEWAGVTKPWNSGSVIALLVVFGLILPALSTVISGGLISTFGHYGPILVIGSAMATVGTGLLYTLQIDSPSSQWIGYQVLAGFGMGLTFQIPIIVAQSTCEINEVSHVTAITLCGAIFISAAQSIFGNKLVQRLVVNVPNIDPSIIVGGGATGFRSSLPASATPGIVLSYMQSLHIVFALSIALAGMATLMSIIPKFEKIKIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA74</accession>
    <name>A0A1Q5UA74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000525">
        <property type="protein sequence ID" value="OKP09374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="9075" checksum="8DB4945DD6E96D74" modified="2017-04-12" version="1">MHARYPFQGKRRCMFRWSIDHGAPPIGAQPTARKPFCSAARFSRAQIDIGASGLQLHRFRWAITGPSYYDPTSPLQRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA89</accession>
    <name>A0A1Q5UA89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA89"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF22">
        <property type="entry name" value="ENDORIBONUCLEASE FAMILY PROTEIN BRT1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="11518" checksum="4774AB05B08F6389" modified="2017-04-12" version="1">MSAKQAILTESAPAPLPGIYSQAIVANGFVYCSGCVPMDAQTGKLIEGDIKAHTHQCIKNISHILEAAGSDITKVVKVNVFISNMDDFAEMNSVYTLYWGDVKPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAE5</accession>
    <name>A0A1Q5UAE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAE5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="11550" checksum="D52D3385592025F1" modified="2017-04-12" version="1">MVTGKTLRKDTALPGNGACPLASPASFLQDSGDSYLSKDQLLALARGKLQRRIGTRYSDAVVTCLTYLDLENEDFGDEADFQDADGIEVGVRYIEKVTMRLNSVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAW0</accession>
    <name>A0A1Q5UAW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAW0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="9078" checksum="0B2AB23068E3EB17" modified="2017-04-12" version="1">MAVGTSGDNSSECTRLMERLGWQLVGRPSNATDVTCLGDRYGEDLSAPRQPGLGSTREEPDLTPWKRRPLRKDGLSIVCICVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB05</accession>
    <name>A0A1Q5UB05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA synthetase YngI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB05"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05917">
        <property type="entry name" value="FACL_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="457"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61127" checksum="778C4A5F5BE12C9B" modified="2017-04-12" version="1">MAIELREFFTKIFWSYQNINQHLTSVVSKHQNDRVSYASLDARSNALARGLESVGVKKGDRVGVMLGNSMEYAVVPLNPSFNAAQVVSALSHLQSSHLIISAESNLPRKDPRSNVPLLEHLVGNLASSRLESESVPSLKQIVLVDNSAGRFDASSYRSLTPFSSIMSQLAADGRPLPPQNLSPRDIVNIQFTSGTTAMPKAACLSHRSILNNGSQIGDRMLLTPNDIVCCPPPLFHCFGCILGYMATATHGSSIVFPSESFNARAALKAVQEERCTALYGVPTMFLEELNLIETGEISSDGFQYLRTGIAAGSSIPAELMKKLHKVLNLTELTICYGMTETSPVSAMTTTDDPIDKRINTVGRLMPHVEAKVVDPVDKSHILPVGTRGELAVSGYLLMKEYWDDPERTAEVMIADSAGKVWMHTGDEASMSEDGYVTITGRIKDLIIRGGENIHPLEIENCLLANPGVGDVSVVGVPDERYGEVVAAFVVAREQGSKSITTEEIQNWVREKLSNHLVPKYVFFLGPADSFPKTASGKIQKFKLKEQAIKLVARGKEAIANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB30</accession>
    <name>A0A1Q5UB30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB30"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="276" mass="30753" checksum="825309A881518CA0" modified="2017-04-12" version="1">MPETPDPTQDNPRDFYQLSVWISWPGDPEFTNTADYTNIGEPLAIPEAHAGETDRPPAEWAHFIWLAPFSVARQAQRLKGKLHELLKNEPVRELTCRKRYFGSGRHQDELIGNSLSNVESAAVFCQGVVQSDDKQCESCLGALGPWAKCVQLESGEGHLAACANCIWNGKHERCSLWRNAQTGSTPERQNQGHQRNRPSISKKMASDAWAEAKRTVNRAKGLSAKIAQALANEQFEVASALLEEQEQWFEDFKCPEGILDLVHPAQPNSPQRPGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB99</accession>
    <name>A0A1Q5UB99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000462">
        <property type="protein sequence ID" value="OKP09758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB99"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB99"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF145">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="514" mass="56508" checksum="87E0AE3BABE0AF12" modified="2017-04-12" version="1">MVDLYHPGTLRNESDLAGTLDAAHEDHFSSHLEPVISKLASIHAPPEFEVYWDSEDPENPRLWPLWYKGLTVAAMSLGATVVSLSSTLYTSGIPGLQEDFHVSKIVALLGVTTYLFGMGIGSIIFAPLSELVGRRPVYIASMTVFLLLLLPSALAQNIESILVSRFFGGFFGSALMSNSPASVNDIVSDKHRALAFGFWSIGPTNGPVYGPVIGGFVFQYLGWRWTNWIVLIIGGVVLVLIASVKETYAPVILKRRAARKRKETQNTNWWTRYDDGVGFAFSRRINLKRPFVMLLKEPICMFWDGYVAIVYGVLYLCFVAYPIAFQQGRGWSPGIGGLSFVGIGVGVLIAIACEPLFRRVINLHRKDPETGMVQAEAMVSIVFFGATLLAIGQLWFSWTCTPNVHWIVPILSGVPFGVGNACVFIYASNYIARSYGIYAASALAGNMFTRSVMGAFLPLAGPSMYKALGLNWASTILGLVEALCILIPVVFYFYGHRIRKASPFIKEVEKLQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBD7</accession>
    <name>A0A1Q5UBD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000448">
        <property type="protein sequence ID" value="OKP09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBD7"/>
    <dbReference type="OrthoDB" id="4349275at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="224" mass="25603" checksum="807035FD0C430D00" modified="2017-04-12" version="1">MKIDDQGVPKVVYHDLMYQAYSRPDYIDLPEFWSTSSDIPATPPLLATEYDDLPLDSFLEGQPIDSGGSLPPPMECLLFPDPGNLQSGFNWPGPDPLFANTQSEDVLVYMSASIPTRLLHWVDICLTELDQMTDQTIEKYRFHLSSTANGREDLYWVRRQILDIISGTRVKQRSLFRLSLRPRTELSTRFPDPACPLHTTQPSATCLDPDVFVQNLTDNRWPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBE6</accession>
    <name>A0A1Q5UBE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4831</name>
        <name evidence="1" type="ORF">PENSUB_5127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000507">
        <property type="protein sequence ID" value="OKP09520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000450">
        <property type="protein sequence ID" value="OKP09780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBE6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="148" mass="17471" checksum="59D2B3D1488CC701" modified="2017-04-12" version="1">MSTITSDEIGEKILQSSESITKSYARLQLLMENYSTIEFRWKKYNTKKRQNRLEEAWQKMPILQRPDLWEYNRTGYVGSSDNPAVFMWPDISLRALKDENTLLDFLSARCHDPPYNFIFADREAVEFGVMTSNIQQEKHLAETYDVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBU3</accession>
    <name>A0A1Q5UBU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBU3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBU3"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="167"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="833"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="95287" checksum="526DC399064F40A5" modified="2017-04-12" version="1">MEYFDFEGASSAHDSNHPSDDVASLDLEFDEPEERDARFDSLLQDQSLDFPANALVPESAEQYVGDSIGPDQDTGVYPMFRAQEPCDFCRRMGLDCFVAKRGVMQNGCTCCISLYRECSFTHAKVPGKFLQTLHTVSENAYIPTGGLTGKRALKSVSYGAFGDDTDARSRKNSARFSRRAVTILKGWLRDHNENPYPNEVEKDELKQNTGLTRIQISNWLANARRRGKVRPSTGTNSPVPGAVDIPGSHPKDPALMTPLERWKYSPPENEPATISDITRALANPPFDPSRQRRTHSGHVRPRHPGSSTNESSHASSEHKRYTASASSLDTSRSSISDLSFASAFSHRSSLSFGSMDRKERHRRRRKPSIPANTFHNQKAKAVRPFQCTFCTDSFAAKYDWQRHEKSMHLILDKWTCSPHGGVTEENGILRCVFCSAANPDRDHLETHNYMSCQEKSLQERTFYRKDHLNQHLRLMHNAKFQPCMDKWQSSIAEIKSRCGFCATVMHTWKDRVDHLAGHFKNGASMAQWQGDWGFEPSIQERVENAVPPYLIDYEWRSPDPWTTVQAQGDGTSPQLEVPNDANCYMRLTRELTSYVHNQKAQGVVPTDQMLQTEARRVIYGNDDDPWNQTCADNPLWLTILKRDTGLESPANNEDIQLSDLGLQPPFTGRGVLQQPPQDAANIFARGVGAGALPSPAVSSPGLRSPAYPPTGFSSTAPSGQGSLAGSYAGSSGMISAGVPAFISDWSSSLPGHASSSSIHADREAPDPLVQMGFDPEFLQRLSDSYSELTPPDMETVPLDASIDYEGKGKQPWLNSVSQTRPLLGLPASDPLAALHSKEGYPPASDAAQSGQPAFRDDSGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCF4</accession>
    <name>A0A1Q5UCF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="169" mass="19658" checksum="4DC119EA8FF04EC8" modified="2017-04-12" version="1">MMNRDRLTSYFKAELYAQVNRKPLDGWEEVPFFRLGRAGTHYPDGSAGVFVPRFQRWGTVEDPLSLVTADLRKQLEGDWFDLQDLEGYLRDKNVLLVLSGGEPTRRSEGQININVSRLISEEFAWVEHLGFNVVMWRRPCIFQQLCKLAELISLSTNYLAKYRNAELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE02</accession>
    <name>A0A1Q5UE02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE02"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE02"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="147"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="540" mass="59942" checksum="8FEC698652EA1EAC" modified="2017-04-12" version="1">MPGRLIPNFVRGSGSLHSSVSSTPIHSNSSSTTSVNEIPHPKKPAHRADRARSPERRLSFNMDHLIHPHRDHSKDKRRSLGRAGRSKERLGKEELAKPSAKLEVLVESPPLVCYGNPSNSTGALFSGRLRVTIPESAGEVILSQFDVRLISKNTTKKPVSSHCPSCATRTEELARWNFLTENLRLKPGQHDFPFSYLFPGNLPASCNGALGQVEYFLLAHAQSTIGEEFNLKLPLNVRRALIPGNDKSSIRIFPPTNLTGRIVLPSVVHPIGSFPVEMTLSGVVDKGDETQTRWRLRKMMWRIEEHQKIVSTACQKHAHKIGGENKGVLHQETRIIGHNEEKTGWKTDFDTAGGEITMQFDASINPTTNPVCDMEAPGGLEVKHNLVIELIVAEEFCPNRNTRLITPTGAARVLRMQFNLHVTERSGLGISWDEEMPPVYEDVPASPPGYFRLDDARSVMEDYQGSPLPLPEYDELERMESLRLDSDSTHSSANSTANSTSNRGRMRFTVDDLVTEQTPPPSEPTSRVASRAPSVDSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEP1</accession>
    <name>A0A1Q5UEP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_3752</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UEP1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057211">
        <property type="entry name" value="DUF7889"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25417">
        <property type="entry name" value="DUF7889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="868"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1227"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1325"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1415"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1456"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="17">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1516" mass="168484" checksum="23067328FEE67EC1" modified="2017-04-12" version="1">MNDPAFDDREGGMEDMDTCRICHGEATEEEPLFYPCKCSGSIKFVHQSCLVEWLSHSQKKHCELCKTAFRFTKLYDPNMPQSLPTPLFLQQALIQTLRTLVTWLRFVLVAFVWLGWLPWSMRAIWRALFWLADGRWSAGGTVQQRGAQSIQDGVEQWAVNGTAAATAALSSMTSSASSAASSSAIAAPSAQAATISFPAGDPLMLTFIKKIIPSLFMPAWTSSGSESGAHTNGLSGSPKPRYPSWLSDVKFLNNLTRWPTINNMIIDTLEGQLITLLVVVAFILLFLIREWVVQQQPMANIAEGEREAALQLIANNRPNEEVRGVRPDLVPPHPHEDFEPEQNLLVEDDNDNDVPDRSANHSPAPSWTDSDDGLPVYDRQAGFQDDDFPNPFQNGHHMEFDHSERQQPTNSQHSDVSLFQNILARANGDRDEILRIIRQEGHEQELSWIVDALTRAPVDQPLPGPSTHATGLFQTQPATAHQTLDPEGENADVQSQADEPIAGHDTHNDQPVATGEDENQNHVPIEHHPAKNVGDRLINWFWGDIGADPHDHEDQPLEDDEQIMQDPALEDPFVPVPNRLDGPPADGPGLGGAAPDGALEGNDADAIEGDDFEGIMDLIGMQGPIFGLLQNGVFCALLIAFTVAIGIWLPYLWGKIALVLLANPLELIVGVPMTALTVVADIVYDTLIGVVGYVMYWLSFIFKVLLSPFGALVPALEWIPRNKSITSTSLSLIDKSTNRLNKVIKAFLVFHESDIPMFSVLSHQALKLHQARVMTLFRSVFAVLKFVLHDFPLRVITLGVPKALSFDVDFSQLKNATVQAQHYIGNFTKSSIFASPGTKLMNATAARTASTNVAVDYDLAVWDTKDRVIAIAMGYLLAIMMGFLYLRITGLLAGANRGQRIEGVVAEVLLQAGGVMKVILIIGIEMIIFPLYCGTLLDVALLPLFSDATISSRIAFTIGSPLTSLFVHWFIGTCYMFHFALFVSMCRKILRTGVLYFIRDPDDPTFHPIRDVLERSITTQLRKIGFSALVYGALVIVCLGGVVWGLFYAFTGVLPIHWSASAPMLEFPVDLLFYNFVMPLAIQSVKPSDGLHDLYDWWFRKCAHFLRLSNFFFPERHPEEEGRHVRRSWWGLLFGSKGDWEHPVIGDAQQAAAEEENRDVYFLRDGRYVRAPASDQVRIPKGTQVFLDVTEDNDRVDGLPDSDDGLHGRANPSFSKVYIPPHFRTRIAAFILFIWLFAATTGVGITVVPLIIGRKITSVCFSSPVPVNDIYAFSSGLSVVGALAYTAYYCRAAVQFLREHWGTYLQSPRELGLLIANIMLDAARLVYIAIALVVVLPSLFALLTELYILIPAHTFIGDETDHVVHVVQDWTLGVLYVQMAIKLTLWHPHSWPAAVLNGIFRDGWFKPNVQLATRALILPLALFTAAAVAAPLSLGGILRWTLFYTRVEAQPEIYRYAYPATLLVVLAAWSVHLALRRVAVWRINIRDDVYLIGERLHNFSEKRARDVGVSRRVITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UER2</accession>
    <name>A0A1Q5UER2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-type alcohol dehydrogenase-like protein C2E1P3.01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UER2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UER2"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="38685" checksum="630E73D1D357EB02" modified="2017-04-12" version="1">MATKLYNVGLNVDENLTFGVFRDENIPTPGDDELLIETLYSGANPADIKHSTHLGIYPTRLGYDFFGKVIKAPSGSAFHVGDSVAGYTPTGIGRPAKYGTHQSYLVCPEKMAFVVPENLPPDHAACLKVVAMTAADALYNLFKLPLPGKSTQGLPGNITGKPLLIWGASTSVGICAIQLAKASGVFPILVSASSERHALLSELGATYCFDYKSPSVIEDIKAVLKNWDFDGVPYAFDTVGSPSGVGSAQMVASCASDDAILVSVVVQKDRRFLMPLAVTDEDVTLRIPGVPHRITIPARKEDHQRALNALQWAVNNYGSQFRLVSVDVFKGRAEDALVELKILADKGRGFGKLAIMHPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFS9</accession>
    <name>A0A1Q5UFS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFS9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6479" checksum="4F04E4F40D12F833" modified="2017-04-12" version="1">MPSHEAPTALSSLFPPMDDLSSADLVGQKDHRTEIRDFRMASANHHLAINYDCLSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFV0</accession>
    <name>A0A1Q5UFV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFV0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="32703" checksum="D3491ED3C6B6F6D2" modified="2017-04-12" version="1">MPRNFFRRYRRFPSIYWAVDNLKRLWILVQGRVDITRTFDGDELNREYIFGLFADPAHVSLVGVPISYSITQFTANDNIASATTVVTFNATTFGVLVPVTIDTWIEFNTDGKITQYDATFRWFEYLLDFLIKGVATKMNSTSPDQAVAYVSDILAKTICATHDKYCTGSDQQYSDSNACYDYLTKSIRFGKSYELGRNTLLCREVHEHMVQFHPDVHCPHIGPTGGGYCVDDMSYGQTVLQKYFDDSWIPFDYGSDQNHALSSRVAQSQLAMPPTLSSISSLSTLADIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFZ5</accession>
    <name>A0A1Q5UFZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFZ5"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="136"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="370" mass="42954" checksum="7280F8CD0025E077" modified="2017-04-12" version="1">MPYDDEVHDAVRNAQPAQQPPHRSHDPSNNMKRSDPFKFGSRYLEQGDDIFEFNAWDHVEPDDEFKAFAETQYEKQRAAPVSEFDQTRFNNDPAKWWNNFYKNNTANFFKDRKWLRQEFPVLADVTQKEAGPKVVLEVGAGAGNTAFPLIRHNENEYLKVHACDFSKYAVQVMRESEEYNTKYMVADVWDVAAEPTESEDSLPPGLGEGSVDVVVLIFIFSALNPDQWNRALRNIWRVLKPGGCVLFRDYGRGDLAQVRFKKGRYMSENFYIRGDGTRVYFFDMEELRQIWSHWTPEKGVQVDLETEPEAVAADPAAPFEVKHLGVDRRLIVNRQTKLKMYRCWMQANFQKRDDTATTEPRTENGVENGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG56</accession>
    <name>A0A1Q5UG56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG56"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49549" checksum="BC5A67CEE106FA5D" modified="2017-04-12" version="1">MSTASTLQDADVSLYLHAELLPNIRQITLYVSLPQTPALEGIRPQIQLSESCKSVTVSLSEPFHHVAETVKLPARVTDATRRVLNINTAASDHRKPASPGYEYSVRMHIDPSDPVLAPRDELIDDYVPWTAADMSSSTRIRCRGCGTAFLKESGPHSVELNDQSLLPGWLWKDLPSGNWAEMMDFWHCHKPDPHEDNPKSEATAALKLEDQSAQIKGYGASSRVEAISGTVLIDVATFLLSDEDCVSLKKGNEEEATTSTPEGSFERTLECATCNSIIGMEDPSARGWRLLKANVSLNAKILNSGSDGEHWQSHPTQMIVAAQLLELIERESARRFVVHFGQKSGLLLWVFNPDLRYSNSSLDHNVNTQQAMKVFFQETREIDKLLAPEIGNPSPLSVEELELPSMVYEALFEALHGSNQMLPPTARQFNEWQVGLLSRFSRTQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGV3</accession>
    <name>A0A1Q5UGV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGV3"/>
    <dbReference type="OrthoDB" id="4368131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="193" mass="21836" checksum="A411689634E919B1" modified="2017-04-12" version="1">MTSIIQRIFHHHAADADPYDARGRSGRCQSSLLGACSLRFASVPVSVPGPVSGDTSLALARLQARQVNPYGGSGDPEWKAKRDHDSLIIFIVVLLFLAAIAAYSLVSWRLGLKGVDCLWWCLRQLNPMNHWEAWCAFWKDRTRQRRRRREGIELQPYPGPPPDAPYQRLPSPARPAPALIRLGRFRFLERRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGV9</accession>
    <name>A0A1Q5UGV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGV9"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="33749" checksum="D175DD18DAFD7E90" modified="2017-04-12" version="1">MSSPVVFVCGATGNQGGALIHNLAQHGIKIHAITRNIKSSAAQILQSQGVTISEGDFDNQESLKKSMSGCTTLFLNLSPNHTKSTAEIEQAKQILAIAKEVGVQHIIYTTALGTNNPEALKHWDPNSLVGTALSGKKIIEGEVRNAGFKYWTILRPGNFMTNYLFPLVRMYGGLVETGTFTTAYSKDTVLPMVDPNDIGKFAAAAVLHPVKFNGKEIEIASQMMGIEAVLNDISQATGRELQVVYLSEEEIEEQSRQNPLIYVQLVMRDLSQFVDMAKLKEWKIELGTFPQFLEREKERVEKTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHS2</accession>
    <name>A0A1Q5UHS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHS2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="154" mass="17693" checksum="9026720B35FF50C2" modified="2017-04-12" version="1">MTPYDGFSRVFYIPDRGFPFNFDWADVEREEPHGWGMCHDHEEFPGSEQSEATGDEADEFDYEEDAEYITKDDMDDDSTNIVSIPSTEEVSSRERLLQRIEEEFLGRVDAMVYDEDIQHFNWLGNPFYQVSSTTPAESLAIICTGPKVPQGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIA2</accession>
    <name>A0A1Q5UIA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIA2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIA2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="61" mass="6225" checksum="D0ACF3AA3DC0233A" modified="2017-04-12" version="1">MLVGSGSANIPASLTYQSNNIVGQWRRAFGSALVIGAGGVGGVVGSLVFRNQDKPNYGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ13</accession>
    <name>A0A1Q5UJ13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase tdiE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000209">
        <property type="protein sequence ID" value="OKP12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30999" checksum="A47B607ED14ABFBF" modified="2017-04-12" version="1" fragment="single">PLEAFHLKRAFEHGQPECHSCMWDISNSSSPLVSLLTCYYQDPDLTLDDSTYGYGSEDWESIAVVRGVDLFPPPAAWVPPNCILEVDDVLQEWTWRKKFDLIHMRHMSGSFSRQEWDLVYKRCYDNLRSGGWIEQVEMSFVVQSDDGSLSPGSTLSHLGPNIIWCGAHADRPCDIADTISSSIRKAGFVNVHEKIYKWPIGPWPKDKQLKEAGAVNFQHWVAGMEGWFMWLLTRFGEPQPWSKEEVYVYVAQLRKELQSPYHHVWHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK07</accession>
    <name>A0A1Q5UK07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK07"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000024">
        <property type="entry name" value="Deaminated glutathione amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="29968" checksum="3F90B187C90053F7" modified="2017-04-12" version="1">MVLAAVGQLCATASIASNLAQCQTLIRKAAAAGAKVLFLPEASDYIASSAEESFALAQSPECGNFISVLQQEAKGESMHINVGIHEMASQHRLKNSLVWIDDKGTITQNYQKVHLFDVEIKDGPKLQESKNVEPGQIILPPFDTPVGRVGLAICFDLRFPEISLALRRQNAEVITYPSAFTVPTGRAHWESLLRARAIETQSYVIAAAQGGPHNEKRRSYGHSMIVNPWGEVVVELGDESEPQIVTADIDLDLVAKIRREMPLLRRTDIYPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK63</accession>
    <name>A0A1Q5UK63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="6727" checksum="D55D955234E92006" modified="2017-04-12" version="1">MFVKLYMSKEQFNMDRKDVVFSIEYTSADDHLAHFTYYWLRYFQARGLVHNGLATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKE4</accession>
    <name>A0A1Q5UKE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKE4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="12612" checksum="0E7FB44945946DB8" modified="2017-04-12" version="1">MESLDQIVACDAQDSNRRPLQANTVSLWALLIKMSFGCANDVDIEQPSGDPIYGIASCTKLITTIAVLQCVEKGLLELDGDISEVLHEWKNPKILVRFDKGGEPVVADSNGVISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKM0</accession>
    <name>A0A1Q5UKM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_1121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKM0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKM0"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="843" mass="93463" checksum="9CAC05C723B3EB83" modified="2017-04-12" version="1">MVNFTIEEIRSLMDRPANIRNMSVIAHVDHGKSTLSDSLVQRAGIISAAKAGETRFMDTRPDEQDRCITIKSTAISLYAKFPDPEDLKEIPQKVDGSEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQALTERIKPVLCINKVDRALLELQVSKEDLYQSFSRTIESVNVIISTYFDKALGDVQVYPDRGTIAFGSGLHGWCFTVRQFAVKYAKKFGVDRKKMLERLWGDNYFNPKTKKWTKTGDADGKPLERAFNQFILDPIFKVFAAVNNDKKDELSVLLEKLEIKLTTEEKDFQGKALLKVVMRKFLPAADALLEMICIHLPSPVTAQKYRAETLYEGPADDKACIGIRDCDPTAPLMLYVSKMVPTSDKGRFYAFGRVYAGTVKSGIKVRIQGPNYTPGKKEDLYIKAIQRTILMMGRFVEPIEDVPAGNIVGLVGIDQFLLKSGTLTTDETAHNLKVMKFSVSPVVQRSVEVKNAQDLPKLVEGLKRLSKSDPCVLTMINESGEHVVAGAGELHLEICLKDLEEDHAGVPLRISDPVVSYRETVTGKSSMTALSKSPNKHNRLYMTAEPIEEEVALAIEAGKISPRDDFKARARVLADEYGWDVTDARKIWCFGPDTTGANLLVDQTKAVQYLNEIKDSVVSGFQWATREGPVAEEPLRAVRFNILDVTLHADAIHRGGGQLIPTARRVLYAAAMLADPGLLEPIFNVEIQVPEQAMGGIYGVLTRRRGHVYSEEQRPGTPLFNIKAYLPVNESFGFPADLRSATGGQAFPQSVFDHWAILPGGSPLDATTKPGQVVQEMRKRKGLKDTVPGYENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKZ5</accession>
    <name>A0A1Q5UKZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane and coiled-coil domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKZ5"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="79649" checksum="FC5F7E772739A709" modified="2017-04-12" version="1">MFKNLKEKHGSFFETKQPTASASAGNDRGQDLTSILDRSQRADLTVLVAEIAESMRVGLLEIFETPEVRSPTNEWSPSQSPSLEKNDEEAPPLPTRPQNGSSEESAAQPQQRQRSGPRRNATAAAAKARAKQRTLSHFQNWRDAVLLRIGEVVNRDDEIQDKESSEAAKSDDIPFDEDRQRIERLRQVYHPIETPLLQLPKATRLLILHSLLLLLLSLKKYSAYSRVLLLYVSSSLDIDVKVLNENEVKVARGLLDTVLAVSQQPENKAEPKKKDNTRMWKVGIASVAGAALIGITGGLAAPLVAAGIGGIMGGLGLGATAAAGYLGALAGSSVLVGGLFGAYGGRMTGRMMDKYARDIEDFAFIPIRGARKQRTENESEAAEQDHRLRVTIGVTGWVKEESDFVVPWRVVGADSEVFALRWETESLMNLGNAISALVTSAAWSVAGREILSRTFFAAIMSAVMLPVGLMKVARVVDNPFSVAKARADKTGEALADALINKAQGERPVTLIGYSLGSRVIYSCLQSLCKRSAYGLVESVILMGSPTPSDGEAWRRIRSVVSGRVVNVFSENDSVLAFLYRTSSLQFGVAGLQPIEGVPGVENFDVSEKISGHLRYQYLLGSILTTIGLQDLDQKEIEREEAALADEDKKQEEERLRNELEAGVEDKDLSVAAEKLKGEKGSQEEGRMQKQVETQTEDHMVQHRIQMLDLDDDDYSSPLPDQSGKYSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULZ8</accession>
    <name>A0A1Q5ULZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5ULZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="876"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1292"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1312"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1412" mass="155935" checksum="3EF8975D3B5C91F4" modified="2017-04-12" version="1">MVSPRSFPFVRPRRNSTKQKNKKGTRLPPPLRLDCRLFHAQVQKDISLMGPPPRAVRGSISGSSKAKRNKGNKDSGSQEVPLKMEIPLASLSIEAAKEYHVECPEKMKTTGRSLTRRNHHQQTRPAITTSKRTSPERSTQTRSVSPQGSLRTIIVLDTPGTSDDEESDISPLSDDRPSAASRSGAALRRFFPELSSANFAVVSPMSADASADQQNLRPIEFSSIFESELHERVHILYKNSADAVESPSTDVDQALEHKPGSSSGSGSEDVFDCASSCYSRRSSITSVGTECFSPAAKELDRYSILSPVAAGVFDDSASACPSRGLSRAPSFASGVPSATSPGPEYAASSIYSSSPTPPSRCTSMSSRISLNDYKNKPLPLEPVQEPSPLAIRRHDHTQQSATTEASLSTGFHSTYRHHNLSHSTSTHWKQSGQACQNCGECAGGRNSGDPVQSRRGRRSEWSEASNGQRLRHIPTLAQAAEELEFALADLARDPHMQQRTLLVLDGPLQISRHNGDLVATRPAPLPPSTKPHSQAQAHSSKSFKKSRSFHTKVKSFDDAISPRSATLKALRSTKERPSPPLPDKESKNKGEAAPKTPKTPKLKDEAKLSFRSSNSISRSTDDFFKSPKMKKSFTLTMPSFRRTHHTRAPTLQEPRLSVVLSSRSETSLLDPHTSTEARPDGPPRLSSHSDPSLDLDEDLDAGAASKRADLLLQLPRLQTQDLAFQNPFEPLSIEEELLALTRTQHEREKQPQPPQPKQMPGAAPSFCAPGPTQTVQHQHPHPAQAVASPRGDAKVSTLQLRIIPPEDEKMLVASELVASEWLRHTQAFVSTAQASSVQLPPEQIYELAATPPSPSSSMPAMFMEQSHMPVDFPIEMPDHLIVLIMGRIDSLDDLFNFVLVNKRFYQIFKRRELFFIKGALFRMSPPAWELREMSPPWKNEWQLLLEPDTPLPEYTPESYLDRYACDIYTLAQLKSMILVRCSPFLRRDTVRGLSGVDIVRAEEVDDAFWRIWTFCRIFGSGKGRENDLEGQMDWLKGGPKARSSFGASSTVTEPFGMNNVLFEPPEGFARGNSVAGLSAKQLYDMTEIWTCLGVLLQPLHGKCVEARNAGIFQGLDIPEGDTVREETALEEWTSYVLTLGLSAVLTLSSLCPAEATTATFTKAQSNGLTKWEPTETETSRSSFLKEAVSRVYEELERSLASSSPKEIAYPQPQSFQRRKQFQEELRTRRLRGPPSREGAPGTSFADERPMSEFSTIVHNLDGRTPRDAPPVPPVPALSFDRLSSSTAASIGPRTPSRTPPRSLTPESNLPIPRSPPLQPVLAPPALRPQVQDPVDRAISRMVNELGFNQDDVKWALKITDTGEGIDVDAAEQLLKQQKRKHERNPFAPRGKDSLLRSVMKRQGSQDSGWRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMU0</accession>
    <name>A0A1Q5UMU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_495</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMU0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMU0"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="480"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121949" checksum="EF797825690E6C51" modified="2017-04-12" version="1">MDQQRFLQQLQIILDPTQGNVKEATGVLQKEFYSKPQSLVLLIQVATGHEDPNLRQLSAVEARGLVQKHWLKVAAAEKPQVREQLLRATMGESQDLVRHSVARIISAIAKIDLQDGEWADLPNILLQAADGGNQDERSVAIYILFTILETLGEGFEEKFQDLFTLFNKTIRDPESAEVRINTLLALSKLAYHLDSEENVAPVKAFQEMVPAMVAVLKDAIDQNEEDRIMQAFEVFQTLLSLDPALLTVHLKDLVVFMNEISANTQADEDVRTQAISFLMQCVQYRKLKIQGMRLGEQLTRTALQIVTELDDSPADDDDITPPRSALGLLDILAQSLPPSQVVVPLLQSLGQYFHHTDPNYRRAGIMALGMCVEGAPDFISTQMKEIFPMVLQLLADPEPKVRQASLHAVARLADDLAEDLSAEHERLMPLLFKNLASAMQEYKGEEDGPTMDIMKAGISAIDAVVDGLDEKDVAPYQAELVPILHELFKHPDFKIKGLAAGALGSLASSAGDSFLSFFDESMHLLQEFATVKDSEEELDLRASVTDAMGEMSAAAGPERYQPYVEPLMRATEEALHLGHSRLKESTYIFWGAMAKVYGEQFSPFLDGVVKGLFECIEQDEDALDVDLGEAARDLIGQEVIVNGRKVKVASADDDDELNGDIEDVEIDEDDEDDWDDITATTPLSLEKEIAVEVIGDLVTHTRSSFLPYFEKTIETVMPLAEHPYEGVRKSTISTLHRSYAMLFAIAEESGQMPKWQPGLPLQVQPAKEVKKFGEILMTATIKMWAEEDDRATVADINRNMAENLRYCGPALIADETVLHNVIQMVTDIITKQHPCQMEFGPEEETLEAGEETSEFDWVVVDTALDVVSGMAAALGQSFAELWKVFEKTILRYASSTESLERATAVGVLAECINGMGAAVTPFTTSFLKLLLHRLGDEDPQTRSNAAYAVGRLVERSNSDAEIVKEFPTILSHLESCLQMSVSRLQDNATGCVSRMILRHRDHIPTKDVLPVLVNILPLKNDFEENDPLYRMICQMYKWEDATIRELTPRLLPVFQAVLTGDEDQLDDERRAELIELVKWLNQMQAGAAPWVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNF1</accession>
    <name>A0A1Q5UNF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNF1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="876" mass="96750" checksum="9ED12B90E77E0FC6" modified="2017-04-12" version="1">MSSPLSSNLFGSPFSAEMDSPDHHLRNLAVWCNWSSEPVDTVVVAFNVEVWCAPNSEIPVLDTSQGVTSVDFADITPYVNLEDLEWFYVLRQDWEGMSDLGSVPEVGSGLAAEQQAQGPVTPEKQSGPLTFEQDTSHATLYPGHSTGQTGPLTPSDTGSVLRNGHTPDGSSPGSRTLELFKASFLRCSFSDYDSDVGQSPSNSRKRTATVASLPDSVTDDERPYGGEKLGEKARAQLKQRKESAVSSTSIPSSFTSIPQTSSTSKHKRERSLIPRPVSVMSQARPDPTKIPLPTDSVPVLDVELRRFENSVSPGEKNSPVDHVQVEHVSLAEAVSGDTMTPLVSPSIRTSPNVSNCYASKALQTGPDVEKLSTVASAGSPCDMDLMSESVDASFGGIPTQGTFFVQPPTPPHTIVRPRLVHTNQLFQVQCPSDIKPAWYKVVVDFEIRLQTRGPRGWYELVVPGLPHLNKFDHGLFSLPMPENLGLELRTMHFISHEMFKNRLVAQFRPCNSELVIPLRPFDFHFSGFLRDFIINQTIRSKVTADKHDSSSCIVEYTAICSLDLIQRTFWAEQCGFYVYIHNGPAGDYTGHLEDPQPETKFKTIQLTSNPGSEVGMARLLVLCTPSDLDMFVIKWEMRLPLAEAGNWMPRITALPEGYEAEEALQSRYLEALEALEAAEHEQEIADNEVKSETVTPESTNVVTPEKSDGVIPEESNGTKAFMPLLMKMFLLFMAPFLLLQPVAFSIGLYDGVLRDGLGQEVRDIFCENSKLCLLKSPWEMMGLSHPKLIPPVPVAPKVTGVFVSMEDVEPVPSSVPEKIDRLPPETVRPPWTPVTCIDHIDYWLGWKGPRHPELYGDAGVECGLRVKQILGYILLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPR4</accession>
    <name>A0A1Q5UPR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UPR4"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000180">
        <property type="entry name" value="Related to UDP-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="927"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="961"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1421"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="390"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1646" mass="181938" checksum="6647866CAC04FDDF" modified="2017-04-12" version="1">MFPTVAPFPSVHPHHHMHPYPPHDAVNQSPYEVNDSAFPATNDPSKSFYNPILRSRIQLPQPVQRLDVPDATASGPNGHATAEHALRRKTPNGTLAAGYDGTLGDTTIQPATKHILVSPMDSNQFLSLQAGLLGDVWQQPGSDLSGPKPMNFPPVFKNDVINPVASGEFVQDANGTSWVRPVNYPPGIDSVLNQSLPLQGPQRFVMHNGAYIPTVLPATLQQCVGPTASAGTGPYGPYWPDGVYIPYRPAAIRDSRFGYPHPTGFFDPNQPAFIQSQIPLGSRPDTSFAWGQSAPGLPTQDPLMKPIFPPRHSDQLPYHARVSRSISGLPSNLSTNNSMNWNGRPSAGPGFQGPGQAVTGNIEFKEKILSWAHGVYVDLLATIHQARRNSISNSGAGGHSQRFLKPSIYPKPPRQPGLDFSQNPSNIPRHNSYPSSQYDLRRQKLDLLANPRINDSHSTPLPQNSTHGRRPSLSQFSQHHHRGSDSQIRDAGRFSVSATGSRFSGSPFNEGSPVNNAASALEMLSHLCMESNWEWIDGMLLGGCLAYGLGDYHKAMRWYSRIIARDSTHVEAISNLAATLLALDRREEALQNWLRAVKLRPSFFEAVEHLIGLLCTSHRGREAVNIIDFVQTSLRHPKDGDCFKADEHASEPESDVESNVSDIAMYDKASFDYDDDMGQVHGFNLGSPDTSTPAGFATSGYAIPGSDNGRMLALIHAKGNMLYALGDNAGAASAFEDAVLIAAGRRRHGIQSLIKQIFAAFSSQTSNGYHQPEPESNESVLLYPDRALQTSKLVFQGGGTPPGLKYVAEGISRNAAVSTTSNSLLSLAKIYQDGMSTVSSGAPKSTPGVRDILALYYLSLSLQPSPSTANNVGILLAGIQNNPPARGLVRPNGESQHPHIPGVVPGSGISLALAYYNYGLHLDSRHAHLYTNLGSLLKDIGQLQAAIKMYEQAVQCDGNFDIALANLANAVKDAGRVNDAISYYKRAVKVNPDFAEAVCGLANALNSVCNWVGRGGIVNSRGFRDRWHVDEKGMLRDAQSSDSGVGWVKRVVDIVDRQLREGEYWGRGLLTPNTAEQLVAQLAIALDSGPVASNRLLSLAKVLQSWAGKKWEGSRIVRLVERAIRSITWQWYQDRYVYGKDYPASKYRRPQLPTALTAPNAPTVLPFHTFTCPLSAKQIRQISQRNGLRISCSTLRLPWLPATVYRPPAPPKPYLRVGYVSSDFNNHPLAHLMQSVFGLHNPNKVKAYCYATTSSDKSIHRQQIEKEAPVFHDASGWPVDRLVQQIVDDGIHILINLNGYTRGARNEVFAARPAPIHMSFMGFAGTLGAEWCDYILADQLSIPPETLSPGRRTTRIEDRMLEDDNCEDMEDWVYGEKIVFTRDTFFCCDHRQSAPDAGERPLSWDEEQMRRWRMRKELFPSLRDDTIILGNFNQLYKIEPTTFRTWLRILARIPNSVLWLLRFPETGEQNLRETAKAWAGEETASRIIFTDVAPKNTHIARAKVLDLFLDTPECNAHTTATDVLWSGTPLLTLPRYKYKMCSRMASSILSSALPGGEEGQRARGELIATSDDDYENKAIRLCMDLQYMPGGEGRARGRLADIRQMLFMQRYKNKLFDTARWVRDLEDAYEAVWAQWVNGEEGDIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPZ8</accession>
    <name>A0A1Q5UPZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="20988" checksum="675917B5CD4B6405" modified="2017-04-12" version="1">MGSHPRDHVTVGIVGGGIAGLALARMLELSGISYCLWEAYREFATHTGASVGLMPNGLRILDQLGMIHKFNEYNVKRGDWEHRDANGVLRTSHNPGAIFEEKIGYGGIFMERQRVLQILYESIEDKTRLHSSKRVVCVVQTGHEAVIVSEDGSELGCDYVAGADGVRSVIRHEIEKATLAKKGPESRESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ88</accession>
    <name>A0A1Q5UQ88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000074">
        <property type="protein sequence ID" value="OKP14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ88"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13902" checksum="DD62FE89087A1D3B" modified="2017-04-12" version="1">MSNPEDYSVGWICAITAEYVAAQSFLDEEHGGPQYVSPNDNNYYTLGKIGKHNVVVAVLPDGEYGISSAASVARDMLHSFPNIRFGLMVGVGGGVPSLRHDIRLGDIVVSAHATGRLAFFSTTSGKPFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQC5</accession>
    <name>A0A1Q5UQC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQC5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQC5"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="426" mass="47513" checksum="CBB065E4F2BC28B5" modified="2017-04-12" version="1">MYVFRNSDLPPDPQFSADLEKLGYTITVDDKIRGIADPETEFKYRINRNERFNVKNREAMDECIRKIVLNRLQEAGLEIWRLPFGDGPQEPNAAATDPHVPILVSKNLSGAARVIVVFGEPVQDLGIWAYRSVGEDGVNFGSAVNFTKHVLGEGTDKTDIALVIANTGQLLWHCASSRAVTHRTWEAADRPAGPWGQATRSWRNNIPGNKDLNEHIQYVFEHVIWPRLGKRSRVDVIGLSEGGQGALEYLQKRWAIWKPYISGICFGNPLQSTAIDLDMSTLTDPQSFTAFLSSRGRAYVVSSDDLGKFQSGYRNHGCNCYASGEELNSECIMAHAWPDMLAWLDMLYKNPDYAEQVMIRAEDMDEETSQALENMAVTDDEDVKAEDAAQTGEATPPMPEQADPQQQEASESCVREGPKPGANEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQF5</accession>
    <name>A0A1Q5UQF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQF5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="168" mass="18926" checksum="852C7C496804B956" modified="2017-04-12" version="1">MYHASIALGALDLSRRSVSTTLPPERKDAAVGAFTAYHTSIAKLKAEILSNNTPRDVNLWTPFFLGLFELMHDVTGEGWVKHFLFGTSKMLQLRGPEAHVAGSGRSFFLTVRVFEICRALIYSEPTFLCQPEWTSLPTKIWNGDDNCHWHPKESLFDLMIACSSISHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQG4</accession>
    <name>A0A1Q5UQG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="5 20">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_11476</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5 20"/>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.240:FF:000002">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000008">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 20 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="22">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKP14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="721" mass="80644" checksum="CA9A7B812EA2D73C" modified="2017-04-12" version="1">MADKEATVYIVDVGKSMGERRHGRSVTDLEWAMKYVWDRITATVATGRKTATIGVVALRSDETSNELREDTSFSKISVLRNLGQFLMADIRQLREAIKPSQTNKGDAVSSVVVAIQMINTYTKKLKYKRRIVLVTNGTGHMNNEGLDEIQRKIQDDGIELVVLGADFDDPEFGVKEEDKDLHKAENETLLQVLAEGCGGVFGTLEQAISELEIPRIKITKSMPSFKGFLSLGDASKYETALRIPVERYFRTYVAKPPSASSFALRSGGQEENEAGAGQSTSGGEALTTIRTSRTYQINDESAPGGKVDVERDDLAKGYEYGRTAVHISQTDENITTLETFAGMEIIGFVQMNKYDRYLHMSNTNVIIPQKANDKASLALSSLIHALWEQETYAVARLVAKEAKPPIIVLLAPSIEPDYECLIEIALPFAEDVRSYRFPPLDKVVTVSGKIVTEHRNLPTEDLQQAMNDYVDSMELDGEELPIDDSYSPLLHRIDTAVRYRAVYPNEPILEPSEQLTKFAHPDKELVREAKDSLEKLMSTANVKKVPPKTKGRKRLRETEKPLSGLDVDALLKQEPKRTKISAENAIPEFKQMLSRADSIEIIHDAVKQMTSIIETQIKHSLGDANYDRVVEGLGTMREELVDFEEPTLYNDYLAALKGKILGDELGGDRNELWWLIRKSKLGLIDQATSEVSKVTEDEAKEPPEPSGVIHRFRLEVCRIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR34</accession>
    <name>A0A1Q5UR34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_4695</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR34"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="35"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="333"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="456"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="333"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP14945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="786" mass="86681" checksum="C5AFC6768B9B72D1" modified="2017-04-12" version="1">MSDSGLTAAGSSTYSSNTLHVGDGTWDTQRDTFLLPNLMGLNFETMRYNGMGNRFKDMAGYHSIIIAHGVIATIVFLGLVPISTLIIRYYGRWNPYWAFKLHAWCQVLTLLLSTVVFVLGWFAVGPKRSLTNPHHGIGLAIYVMVIFQVLWGWFMHRKESKRVRHHVPLKLVIHRWIGRGLALLGLAQIPLGLTLYGSPKVLFILYAVAVFALLMVYFILSYLYDDEGFHMASEHGSRYTGPSVVEEHHGGGGGGLGPALAGGALGAGLASLFKKRARGRTTSVAYEDSRTSYSDEKYSDESSRHNGGSGGWAKKILGIGALAGAGMLAKSWWDRRRQREDDSEVGRYRPAHSRTDSYTEDSLSRLEDGRPEPAHPPVSGRPPSRPPSRPQSPGSSYYYNSTYLSEQPERRPSHGVRDALLGAGAFAAVKRLFSRNKDKDDEEKRRLEDIRRRDEEDEALQRANSKRRRNEAGAGAGTGAGVGPYPQRRRPSPYTESDLTPTDLTPRPRPPPQRITSGSSLLTPEPMATGAAHGAPSDIPPLPPIHQELSGDFPSAERPHSHHSYHAEEIAAGAAAGAALGAASSRRRNSSSRRRDESRRRDDSRHRSDHVESPPVSVKVKMHNDGRHVTLRRLTEEEAAAQREARRRERRNSRRRGSSAGSLSGDEGRDYDRWRRVEELERQQAEQIRREQQTAAAAAAASAAPSASVPPSSFHPSQSQISHVPPPPPPVPPPAPSSMPYGPGSVTSPGTWTGTEASGSYANNRRRRRAERARAKERQQHGVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR43</accession>
    <name>A0A1Q5UR43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR43"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="471" mass="51382" checksum="E21E3429FA4ED398" modified="2017-04-12" version="1">MKSMRAPLGSVDTRLKMTDTPEDGLLASSFASITRIDDLLQRSAQPLDSPGIPERKMNRVQFASDRSHGRGIGKPYPRLELDVNLDHYHSLDNFTEPVSPRNTPASISCCASPGEPARPRTSSAPQIQSLAFEWLDGKSEGDLKWLDGNTESGMKAQKRRFSVDDEPRSSTTIPPKDIAPTAEIGSSEQIEDVSRHVPGVRSSPPPVSLPKPHSPPADRSSPAVGRKIDYVSPHCHQKHFKKWRGSNHAQRVSPYRSPPKARSLNRQLDAPFSYLLPSLGLQGVTKDSASQTDPSDETVEHNIPEKGDDVAIGATEIQVGTPPSPVSDFVGLSLSIRQVRHPGQQSALTVNGGAFQVELTSVPFPLRTSFHDGRKAENPADRPALDDLVFHTYLVLPVFVAQFPVAVFSVLNRACNSRIGTILLYLEKMFWSIVIAFFLAFLAKFRRPGTGPGYGPGGPGVGRRKATASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR62</accession>
    <name>A0A1Q5UR62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000037">
        <property type="protein sequence ID" value="OKP14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="167" mass="18451" checksum="53EF998D2423A85F" modified="2017-04-12" version="1" fragment="single">ELAFELGTMIDAALTSTTDGLIWFVVACITQDQGFIAKARKGLDAVVGRDRLPVSEDKPNLPYITAIVEEIFRWRPAGPEGVPHLNRKEEVYNGYTIPKGSVIVPNVWTISREKALFGAIPDDGKTLRAPPAVAFGYGRRTCPSRHFARNAIWIVLPSCYGDKFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URI0</accession>
    <name>A0A1Q5URI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="125" mass="14584" checksum="CE06790A7ED61DD9" modified="2017-04-12" version="1">MGLLLSCRRAYEEGIDVFYKETRFYFGHGKALSQLINFLPPARLNTIRHITLESALFPGFDETRSLPKWSRMIRAAKQLQGLRSVTAYVSPWQVEQTEEMVRLLEEANILRLEIIYAYVFHWSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URI3</accession>
    <name>A0A1Q5URI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional epoxide hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URI3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886142" evidence="1">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="37150" checksum="F94A89D8AB0ED141" modified="2017-04-12" version="1">MRTVYTSGGFSLLSLFAFSLTAIAATISTTATGPGSSLPTLGPVYYAKTPKLSIEYYDSAPKNTKAPVAILAHGFPYSIDTYVDVVPKLEKEGYRVIVPSLRGFGNTTFLSATTLRSAEQAALGKDIIDLMDVLKIEKAVFAGYDWGTVVVNVAAALWPERCSGMVAANSYLIQNRATAWNVAPASSYPVKWYYYVFLTPPGYSSLASDTKGWAEVLWSKNSPNWTYTEAQLDAASLAFHNPDYVDIATNFYRNRLLYAPGDPSYAELANKLDTQPLITVPSVTLDPDQAVVFPATNGSTTAKYFAGPRVHHIVKGCGEAIPLERPDVFANAILEVAKLGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URI6</accession>
    <name>A0A1Q5URI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URI6"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP15090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="13109" checksum="92BB054C895E5A40" modified="2017-04-12" version="1">MSYQKPEKEFGEGPKVHKIRITLTSRKVASLEKVCQELIDRARSKSLQVKGPVRLPTKTLNISTRKTPNGEGSKTWDKYEMRIHKRLIDLLAPTETVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNY1</accession>
    <name>A0A1Q5SNY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNY1"/>
    <dbReference type="OrthoDB" id="10471712at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012682675" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="9361" checksum="A89F949A9D469F82" modified="2017-04-12" version="1">MYRYSIIIALLTAVATIQAAPLNLFSHPRDGLLGDENTSDMTSTKRSEESSINGDIGVGLIARDDEGLVGPFDVDGILPVDVGGSIVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP01</accession>
    <name>A0A1Q5SP01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="15666" checksum="B7AFDC073455EC65" modified="2017-04-12" version="1">MTSVAGILLVTVEEIAELAAAINAYCKANVSRDRGYSTEDRVTDKELVPTTRARIRGRVQLRHPRPLSQELARRGKSADRLKKATYSQEQTIGNEADDSSRNARKTTAAVWEYVKRPKKRQNSKTHDCLKIDMDMDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPS5</accession>
    <name>A0A1Q5SPS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000766">
        <property type="protein sequence ID" value="OKO89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPS5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPS5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="239" mass="26165" checksum="5387FF42BABC162B" modified="2017-04-12" version="1">MTQPASDVLEAFGISTRPVPVAGGRNLCFKAGDIILKPSDDDQEAEYVGSLCHSIAALQPTNYYVPEPITSQLGYVYKGWTAWTFLPGKSEPNLEAMLEACRGFHADTATLSTEKPEFLKQRLDRFTEADSVTWEEKTLDEVADVNTEILSIIQPALDQLLKLRKPILADLKNQLIHGDLTGNVLFDADTNVPPGIIDITLYWRPALYAEAIIVADGLAWLGKGAELIEAFGTDETAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQP0</accession>
    <name>A0A1Q5SQP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="166"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="269" mass="30850" checksum="14A81A13DA90F190" modified="2017-04-12" version="1">MSRQNQQDELAYPHFALIYIDRDGNLRHEASPSIRNSREAILSPGVTNAFLQAVARSGEAVTSHSLVEAGATTPSPPQRALGGQVALRPLLNRATQSPETIGTDGHHRGPMGPRPTIQPAMWPRQQQLQLQQQQQQQQQQQQQQSRQRPWNEEVSMRSNQKALISIRDKDFLQRYYEKVFQNLQQTNCRVLAKAYVKLVEPRKQVNYPYNGRKIVAGRTQQLEPDETKPPWWPSGVSHREPDHLPKAGTRERHILFEVWLAADEMKRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRJ3</accession>
    <name>A0A1Q5SRJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC transporter CDR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_13300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SRJ3"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1274"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1353"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="162"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="862"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO90583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1503" mass="169248" checksum="3EAB70807A36094B" modified="2017-04-12" version="1">MASPQPPAPFGSSAVSQTTARQMNQRLEEYTSEEGSQKDSAGDIDDSATPVTAEDTENIRHKEITALARTLSQLSNKGYAEKDAPHHEGINTFLETDQNPELNPNDADNFNSRKWAKNFLQMTSRDPDRYPRRTAGVSFRNLNVFGYGTAADYQTNFGNAWLKMASWVQGQLGLREKKRIDILRNFEGIVNEGEMLVVLGRPGSGCSTFLRTIAGETHGLFLAEGSDIEYEGISWDHMHGRFRGEVIYQAETEIHFPMLTAGETLLFAAQARAPSNRLPGVTRDQYAEHMRDVVMAMLGLTHTMNTKVGNEFIRGVSGGERKRVSIAETTLCGSPLQCWDNSTRGLDSSTALEFVKNIRLSAEYSGSTAVVAIYQASQSIYDIFDKAIVLYEGRQIYFGRADDARRFFVDMGFYCPDRQTTADFLTSLTSPSERRVRDGFEGLVPRTPDEFAARWRDSSERKQLLQEIQDSRDHHPVDGEKFESFNRSRAAEKAKGTRAQSPYTLSYAMQVKLCLWRGFLRLKGDMSMTIASVIGNTIMGIIISTVFTNLPNNTGSFFQRGALLFFAILLNAFASSLEILTLWQQRPIVEKHYKYALYHPSAEAISSYIVEMPSKVLVAVTFNIIIYFIPHLRRTAGHFFVFWLFSFTTTLVMSNLFRTIGASSRSMAQAMVPSSIFMMILVIYTGFTIPVRDMHPWFRWLNYLNPIAYAFESLMINEFSGRRFPCSDYVPGGPLYSNAPLSSKVCSQKGAIAGQDFIDGDAYINTTFHYYKSHLWRNFGILCAFFIAFLIAYIVSSEYIRAQPSKGEILVFPRGKIPAFAKKTRQDDDPEEAAQGEKQQVVGEAQDLAVRSAALAKQTAIFHWENVCYDIKIKKKPRRILDSVDGWVKPGTLTALMGVTGAGKTSLLDVLANRITMGVITGEMLVDGRPRDGSFQRKTGYVQQQDLHLETSTVREALVFSALLRQPHSTPRQEKLAYVEEVIRMLEMEAYAEAVVGVLGTGLNVEQRKRLTIGVELAAKPDLLLFFDEPTSGLDSQTAWSICSLMRKLADHGQAVLCTIHQPSAMLMQQFDRLLFLAKGGRTVYFGDLGENMETLIKYFEDKGSIKCPENANPAEWMLEVIGAAPGSHADRDWAEVWTNSSERAQVREELEVMKSELSRKPVPEATAGYGEFATPIWYQFLVCIQRMFQQYYRSPGYLYSKTAMCVFPPIFIGFTFWRMPNTLQGLQNQMFAIFMLLIIFPNLVQQMMPSFVTQRALYEVRERPSKAYSWKAFMLASIFVELPWNILMSVPVYFSWYYPIGLYRNAPPGEVTSRGGTMFLLILIFLMFTSTFSSMMIAGIEQPETGSNLAQLLFSLCLVFNGVLASPSALPRFWIFMYRVSPFTYLVSAVLSTGLSGGTAECSSIELLKVDPPSGQNCSAYLSQYVDLYQANLLNPEATSGCQICSIRSTDAFLAQLSIKFSDHWRNVGLLFVYVGFNIVMALLLYWLIRVPKKWSRKVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK5</accession>
    <name>A0A1Q5SRK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK5"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="216"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="358" mass="38387" checksum="AC847788B06FDA23" modified="2017-04-12" version="1">MQLGLSENLSALVARRFAAAKDGGHLIFSSTHLSIITTAGIPYQLRYCPALAMKPKDLKQNPSPGPKPPKIDPFENPSPDLLLASFPPQNPTHALVLNKFPVIPNHFILATKAWKAQTDILETADLEATYECLRAWGDNPFSTGLSSPNPSSANSTNRLFAFFNSGEDSGASQPHRHLQFLPVEAMHQPGTESWSPLIDLVTAQPQQNPSTFQSHPSLPFAHFALPLPSNPSPETLHAIYIALYRAAVAAAQGRDASHGVQSIPTHGPSAISYNLAMTLETMMIAPRIAETARVPVDTAIEGDIVDHGVVSLNGTILAGTLMVKAQGEWDVLRTKPEVLGRLLRDVGVSGVGMGQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSJ9</accession>
    <name>A0A1Q5SSJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSJ9"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="242" mass="27296" checksum="E99B095EFD8C828F" modified="2017-04-12" version="1">MAPIRRYLRISKYSVLECRIYLDNPSDSRWLLNPRDPVLPRIFAAIQPLVLPKLREENERLWSRKKGKPVKDVIAEDEFEVAIFLRESRTRHALLTRNKTFHQPDSKKNKKLKPEPAEDLTEDSAGPAKSARAEVILDSDDSEAEVDLSNIPEAAGYGNGPEAIALSEIGTEPQTGEEPTGDEKKLRFSTHYESFNITGWVLCLLITRKGDRAQGRTATSEPKQPLMEEWISSQAQTGLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXD9</accession>
    <name>A0A1Q5SXD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXD9"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="35985" checksum="EE9B799CDD5ECF23" modified="2017-04-12" version="1">MPFSTALTRKLGVAIPIIQGGMQWVGYAELAAAVSNAGGLGILSALTQPTPEDLRKEIRRCREMTKNPFGVNLTLLPALVPPDYAAYAKVIIDEGIKIVETAGNNPGPVINQLKNSNLTILHKCTTIRHAKSAIKLGVDFLSIDGFECAGHVGEHDITNFILLSRARQEIKVPFIASGGFADGQGLAAALALGAEGINMGTRFMCTVESPIQHRIKERIVAADENQTALVLRRWRNTSRLFKNKVAEEALKVEKESTTGEFSEVAPFVSGKRGREVFLNGDAEYGVWTAGQAIGLIHDIPTCADLLPRIEREALEAMHRMQSMYTPPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXF3</accession>
    <name>A0A1Q5SXF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein dip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="154"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="731" mass="80859" checksum="964C00E942A266EE" modified="2017-04-12" version="1">MEPEVSEPQQFWNDDFLSSEYDISRCSYKLFASTIFGAHADYVRRQIVYCLLQEDDLNTLHFIASFLLFDGRQNEAALQMMNEEGVFARLLELIQSLRRDDTDGGAGLHQLLMDLLYEMSRIQRIKIEDLVLVDDDFIRCLFDIIEDLSYDVTDPYHYPVIRVLLVLNEQFMISAHDPVDERSSSSHLTNKVIKVLSVYGSLYKTFGENIILLINREELAANTRTAETSLQLLTLKLLYLIFTTPSTYEYFFTNDLHVLVDILIRNLLDLPEEASALRHTYLRVLYPLLAHTQLRLPPHYKRDELRRLLSILVRGQVSYGNETEQEKIIHFEEVDETTRRLVGRCATVDWLREHQDITTPVQEIPTQIVTATIDTVLDEGIQQDSPIDMDPIDVTRTLSHMSTIPDSPGTTSPTRMDSLDSRGSSEAPESRRKLSAIHRLGMQLEPASASSLSVQAVAAQHEKPGVITPSRNDGRTIDLVGEAPTLRAPKIKPEPPKSRRWRGRRLAVDEDDQHSTGTSSDRNTIPEGVEISPTSTHTAPTPTPTTPSSTINATATGTTTDRRNSTTTSHLIPPGHPRRSASNPPPALPPPRRSTQTTPSTSHHRPAPASTGPSPTPSTCTSISINKHGQKPAPPKTRRWGRGKAQAHAHTDSVESGVSTGSQAKESDSEAVALAVSGTADAQAGEDGGMLPDPFSPTSPVSPTLLVSTADEKGAAQPVSVEEAVQNVSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXF9</accession>
    <name>A0A1Q5SXF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXF9"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14971" checksum="5391A1EA3A4AFE74" modified="2017-04-12" version="1">MAKPQTLNPRSLQTRLSHILQHWPSDAVRPASVSVQTYLQNQLGQNQPTNTSSQSPSTTSKSTPKISESSVNALSALLENRFANRYPLSEKIRYPASDPEHYDNLIREFAEAPNRDWFGRLRKRLGGLLRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXP6</accession>
    <name>A0A1Q5SXP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXP6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXP6"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="431"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="828" mass="90933" checksum="63A0EA231301A13A" modified="2017-04-12" version="1">MAMAARPQTPVQDAYSIPHPNETGTLIRGYSTMRSSSSRPNSYAGTGSAYYNHPEQPSQLAHNPRFKEDFETASRRSSVLLDGPSGASTGMQRSASLMSPGPSRSGTLRKKASLSKKGSLRRNGSRRSMRAGSVRSLSLGDREKYHSEGVDDVNSAFMVPIPTTGNPTEVLANRFQAWRKILKDLIIFFKEVQKSYETRSKLFLSASHVMNNQVTPPAFLQSGGLADATEILQNFHRQGYTEANKAVEVEVEVISQLTGLRSDLQKKTKEIKSLSADFKNTVEKEIDGTRKAVRNLHESLGLVDTDPSATSGKGDPFLMRLNVERQVEKQIEEENYLHRAYLNLENSGRELESIVVSEIQKAYNAYASILKREADEAYDTVEKLRAGPISMPQDHEWNAFVAGTDELVDPRIPLRNVENITYDGKDHPAAAEVRAGMLERKSKYLKSYTPGWYVLSPTHLHEFKSADRVEWQTPVMSLYLPEQKLGSHSQEDSSSHKFMLKGRQTGAMHRGHSWVFRAESHETMMSWFDDIESLSNKTGEARNAFVRRHVRSVSGRSTHSEVMEDDEADRTPYSAESVVLGQERPTSATRQPGGAFPSDVQIDRHLQAPLSPSSGDSSGRDMIAAAEGLPDGTGAAGASRFYGGHESATASPQPVNDDGSIRVDRSRSRMSRHDSYYGDWIGPSAIVAQQKKSQLSETANADAREIRSDGDHNSVVAMSGVLENAGRRESSAPAQVARRESVSTVPTNTNGTDYTNNTMATSLDETPEFIKNGAAVASGSIPTKNYEDGYAVPGPTNTGPELSLPKRDSVVAIDMKIPGRYPPTNVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYX8</accession>
    <name>A0A1Q5SYX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sarcosine oxidasee (formaldehyde-forming)</fullName>
            <ecNumber evidence="3">1.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sarcosine + O2 + H2O = formaldehyde + glycine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:13313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="EC" id="1.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000189">
        <property type="entry name" value="Monomeric sarcosine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008425">
        <property type="entry name" value="PRK11259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="46"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="426" mass="46657" checksum="1417E3755F9738D3" modified="2017-04-12" version="1">MAITGIPMYYPHVDGGIRDEGLSLRGLKSMAIKQSFFGEIKMDQFDVAVVGLGVLGSAAAYYAAKKGAKVIAFEQFEFGHVHGASHDTSRIVRTSNFTPEYVALAKSAYKDWAELEKSAGQKLLTITGGVVFFPEEPNTPALATEFTKSLDTNDVPYELLDSQEVKSRWPQFQIPENVSTVYTADTGIAHASRTVSTFQALARAHGAILRDQTRVDRVVPKASGTGGVVIKTSNGQFQAAKVVLATDAWINKLLSPLGTHIPVSVMQEQVTYFKPTDAANFESDRFPVWIWNGATCYYGFPCYGEPTIKAARDTSNNFMTPEQRTYVHSPHLLNQLSGFLENFIPDKARQPLRTITCQYTITPDRQFVISPLENHPDIIVGLGAAHAFKFAPAFGRVLAELAVDGTTKEDISKFGIPTAATYSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZA0</accession>
    <name>A0A1Q5SZA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPI inositol-deacylase winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="681" mass="77133" checksum="5CD50BCBFBF5ADC5" modified="2017-04-12" version="1">MAEFEVYTTVAKIIRNRTWHPGNTMEHSAHHLKGLQELSVAKQYKSSYKYPGLAEDKLFEAKYPHKHRGQPVCDLCYGENEVCDEAAQTSCSDLECDESYLVARASSNSSEFRALERMKAQGLDIFIGRVSSGAAVMKSAEHRDKIANQHNIIGFEMEGAGLWDELPNLARRCFGWVAAAQRPLTLDELREAIFIEINQRQSIPERLPNDNHLISSWCENLIVFDEEEGIVQFAHHTVREFLTTRCQDSELNTFHIKLKDADHFVGEICVTCLNFGDFKTGLTRLPKLQQSMPRILPSNIARSALGFSPASKISMNALRKFIPGSGLNNSIFDVVGSLASFNEEPILPMLKLRREHPFLEYASFYWFEHTRRFKKTSSKTWDLWQKWVEYGQSWVQFPWTTQPLRSYFPDPPGELPDHDIEYLTYYRSPNQPLSLTRNQPLNWFFSSRHTALVWLIFHTVAIIQTDQTPEEIDITLLAQSIHADSTLLLDSILSASYSVPYLLQTPIYGLLGHSGDIYVPRGNRKFNALQSASSIIERKRMEGGPVHDCGSESIGKTALHFASEWGNQEIVRLLLEAGADANALLNSANEGVTALHLAAKGGHVEVVQLLLEAGENIYAYTPPYKTIYRCVLDLDNLLGGYTALHLAASHAKNEVVKFLSRREQNWMPLVSEMVPLLLRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0E6</accession>
    <name>A0A1Q5T0E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">beta-glucosidase</fullName>
            <ecNumber evidence="4 12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_12027</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 12"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0E6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0E6"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010283034" description="beta-glucosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="782"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO93748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="863" mass="93595" checksum="978859C741A9CEE1" modified="2017-04-12" version="1">MKVGWLEATVLTAATVASAKDLAYSPPYYPSPWATGEGEWAEAYRRAVDFVSNLTLAEKVNLTTGAGWEQEHCVGETGGIPRLGMWGMCMQDSPLGVRNADYNSGFPAGVNVAATWDKRLAYQRGVAMGEEHRDKGVDVQLGPVAGPLGKYPDGGRGWEGFAPDPVLTGVMMAETIKGIQDAGVIACAKHFIGNEQEHFRQAGEAQGYGYNITESVSSNIDDKTMHELYLWPFVDSVRAGVGSVMCSYNQINNSYGCSNSYTLNKLLKGELGFQGFVMSDWGAHHSGVGDALAGLDMSMPGDVVLGSPYSFWGTNLTVSVLNSTIPEWRLDDMAVRIMAAYYKVGRDRVRTPPNFSSWTRDEYGYEHNIVSENYVKLNYRVNVQRDHANVIRKIGSDSTVLLKNKPGALPLTHQERLIAILGEDAGSNAYGANGCSDRGCDNGTLAMGWGSGTANFPYLITPEQAIQNEVLNYGNGQTNVFAVTDNGALDQMAAVASTASVTLVFVNADSGEGYISVDGNMGDRKNMTLWQNGEEVIKTATAKCNNTIVIMHTPGSVLVGDWYDNENITAILWAGLPGQESGRSLVDVLYGRVNPGGKTPFTWGKERKDYGAAILTEANNGNGAPQDDFNEGNLIDYRRFDKDDVEPIFEFGFGLSYTKFEFSDLEVKVLNADKYEATTGKTKHAPVLGKSEKASDNLFPSGINRVRQYLYPWLNSTNLKESAADPDYGMDAKDYIPEGATTGTPQELLPASGPSGGNAGLFEDLIQVTATITNAGTVAGDEVPQLYVSLGGEDDPVRVLRAFDRVSIAPGQQIQWTTTLNRRDLSNWDVPSQNWVISSAQKKVYVGNSSRKLPLSADLPTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Z4</accession>
    <name>A0A1Q5T0Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Z4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0Z4"/>
    <dbReference type="OrthoDB" id="2890403at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012095395" evidence="1">
        <location>
            <begin position="20"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="605" mass="63233" checksum="BDB1D142BCD9EF9B" modified="2017-04-12" version="1">MRGTFILSLLSAALGASAGLTTSNLETHVDVLALDSAFNPVKEAYWTGYPHHRRTPFAVSPDGKSAYIAYLDSSETDVHVQELDPTTFEATGTTVTVSGGKEAGGLVAHNDGFAILVNEAMPSGTTNAPPSDTPVAVLYRYTEGKQTWKTWLGGPGVHASDGLSASPDMNGDLVYSESEGLYGAYFVVTDYTGDASGHYGDSIQYVTKTGELNTISGASSSWGCSHNTGIAFEAADQAPFASICAEDQGAIWLNTKGQGMMNDGVKISNENTTNGGSGEPMGGMSGSYSALARFADTTKYIFAWVSRGAIDVTENTWIGDGYTHVNNRTNGRNVAISLFTDKYTKVGDQATSVVGTEDGDSQVNWVTKGSNDCSNAHAATFGSSSALVTWEEISNPICDYIAMGCRGEFAGTFFQEVNSDGTTIGDAFTSTDVYVAGDMVTMSDGRICWPYVSMKWDLSQAVGYGTTSSTTKKMSFACMSTGETTNTTTSAEITTVAATKTTAAAETAAAAIQTTAAVETTSAAEITVAAVETITTAKTTTTTAPAEQAVQAVTTFATQARQSLQPSTVVSTPNSVVSAQAIPTGSAQDTLDFIRAVFRFLVGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T140</accession>
    <name>A0A1Q5T140_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T140"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="40522" checksum="0294B1EBAACE8711" modified="2017-04-12" version="1">MNGTTPPFSLGEKLAAVVTELILSNADEQPTPSSCAESGKTSRKTSGKTSYLPKFRAPDRRPTQLDDLDDSIYHQIYPTQEKARLCADAKHFYVVSSGASLVDPGIIMASAGTGNDYLIADYHEEADDKTLDILRKVGAASMAFLKICVYAGLMSDWQFDNLLAMTVQFRVLGYWRVHSMPRRPSEAYGSRMTGLIIHGHIDLGLMVGVVGASLATGETINEAEFMQLMETCTLINDMLDFRGDKVQKQRENVVRHGLRGSACKYLDGSIAKCVKGAAELIGRRKINAGHYEPLQLGSHGMPSQGALNSYGTLGNDGPRVTMKRKALQISYPKYKQTPETHFAWLADAAREMLNPSNLRRLVDFVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1Y2</accession>
    <name>A0A1Q5T1Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylsterol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1Y2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1Y2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="29273" checksum="B12DD97AC137CFC8" modified="2017-04-12" version="1">MSFAIHELFYFGRSLPWVFIDSLGFFNRYKIQNSKVPSLREQWDCAKFVLLSHFTVELPQIWLFHPMAQFFGLSTSIPFPYPWTMAYQIAIFFVTEDTWHYFFHRALHWGPLYKAIHKIHHQYSAPFGLAAEYASPIEVMILGFGTVSSPILWAAFTGNLHILTMYIWIVLRLFQAIDAHSGYEFPWSLHHFLPFWAGADHHDLHHEKFIGNYSSSFRWWDYVLDTEYTPDALKRRRGKKVEAKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T264</accession>
    <name>A0A1Q5T264_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T264"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="955"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1281" mass="138538" checksum="86BAB16A4E178B1E" modified="2017-04-12" version="1">MPGNLYTNPPDLAQSNLHPLNDFPLSGPLSPPSEGGSPNQSLATWVNLSRNLPKTDLNLTLNQKMSSSPYARQSPAGAGGGHHSPLELNTTDPYLSAQSDPEESDFHASAIRLTPVNGSPNHTSSSYDEARRPSITSQGYLAPGGNDYPDASSSTSATNQTGGFLDPTEVMVNFSALSNEGTPLVFGAGESAAAVSNAQWLSSIPGDTTQFLDPEHTMPSPSSLQETATVQSNANPTLPTQALFVAPQQSGISSNPAFGPSRLTVSTNNAYNNDLASPSPRGRSPIITISRTSRGDSPDENAPETRPSRSLLSPIGPDEMPNGYVDDNDDHRSISSVSVMPSHNGTYVRISTATRRGLDPFSRGDEYGPSPNEMHGKHQQEQKNEEIGRWTATVSAANSEAGDDTPDQSRGRNKVTNRIRALSTGAQPLQQADYFNLKESDRTVLGPGLMLHESSDDGIESEEDSDGSTAPDSLPALADDRGLYDYSTPGVYMSQEVASPEKSFPLYPWQDPPRDPMRRGDMRQPKSSAAAMATYERRAREQDAASITATIDNNSIINFSAGFERSLRITDAPKKHASWSSALFKRGQQRIKRQASDLSLASAQSNFQPGVPELPQPQRKESAGSSYRHRLSLSSKHSPKSHSRSPSLTNALMSMTGQMAAVGGSHSVQAVSPHADASPKTFPAKWGRDRAKSEVPRPTTPGLLDLMTTHGGPPVASLSRYCKAEPDVAEPRASIAPSLDVPGAEDDEDMDVCDEKGLVMDFPAIVRLPVPTMEGFKSQIMQLNPRLDPALINRFAGEQVRRYRKLIEYQQKHATAVAKGSCKSGSFCFALGGQATLLPQRKTAADIESGQTQFRITDGHDQSYLGSEGAVTAAQFPPGVPLPPVARLPAKFECPVCFQVKTIQKPSDWSKHIFEDVQPFTCTFPGCTEPKSFKRKADWVRHESERHRQLEWWCCTYHDCTHKCYRKNNFIQHLVREHKLPDPKAVVGDGSARIVDQMVEDCKHTTQHTPAQEPCRFCGNNCGTWKKLTVHLGKHMEQLAMPVLELARQSCASQGQGQGQPRPIDTASPFEAGNNTITSSSGPVQAPQVQAPVQQAQGQTQAPTQTQTYYGDIPSFNFTSMTGGEISMEPESIMEPESLIDPLQQPGDQFSGYALGPFDPNPNSHAQATTSATLYPQGHAHAHAQAQAQAQAHSLAHAHAHAHAQSLHQNSVSYPPLYTPPPPSMDQTVAPNAPHSFSISSQLPPQAAQQQQAGYQTYQPVAPSSPYMSGQYNSSYSSQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2L9</accession>
    <name>A0A1Q5T2L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2L9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2L9"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="441"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="906"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="942" mass="108788" checksum="4C47507DC92BD5AB" modified="2017-04-12" version="1">MATNKSKWKGRMPFDPDENLKSIDSRFLSKPAMGVIEPPDWPPRPDIFDEVLLRKPVTPERAHDAYMAWYLPDQTLGKVWQQWDEKKQRPFTRPPDRELDIHVLAHNVYEHLMSDPLLPVAYEDGGKIIAQQGLDRKYDLSKNMQQTKQAAIDSGSLGYLEFLDLSQLRAECEERGLDTSGDEAKLRARITTDTMDKWSGMLTKSDLSYWGVKRTHKYGLEPWKRVKATALEMYTVAIQISPYNPTYWVSRAYCHYQLGFFDLAIGDAYRAQLLCDVLEQSLERNRRPGFYMRIWEAVEAHLMVFPRDKKGNLNPEVARMRRANGVNVFVPTLQKSLHSIISLSLAGLNAWHDYLDHMKILETRLGMPDRDVRVPQLRNTLSEKAAKVYEEQTQHKKKLFFHEHSAGAVPASRPYPFEAQDVDRTSSSFLDKLNKNVFNENGITGKDSKPTCVIRKAGGDKQEIGVFARSAIKTGAVIHIEEPTIRGHLPPRRLPKDLHGKAYDKSRCENCLKPISPAMVRQLKNKAPTKCPCADMWLRQPATPGRMFCKAPPKWQSEKSCLEIAREIHHFGSCGKDWQWLYDSMRPVVSTWMGQEFISHTNEGHGTTLMLLLRNVFEIALHRRQEEPDDNMRLNAHEIDELLVLDGNSKSWRESWFPFNLAANIKVPFDILESLGVDIFQRPEFDTWIIQIILRKLLVNAVPWDPRRQGEVPDRLATDRDKKLYAPDVQFERMEKREPLMDIDPSLQNLYLFPGLSMFNHSCAGSHNADWGYDKLVPNRVIVWATRNIAQGEEIRIRYRNHAIKSQRRATRLFGGPCKCPRCRRDPPRPQTPDSENFSDQTYPSEDEPEPVISPLRVPYEKQNDNENPNPLAMQIARGGEERPTYKEHAVVKDGKVVIYRELSVRKPPQSPTRKRKLEEMEAEEKEEERGNEKEEVVMVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y9</accession>
    <name>A0A1Q5T6Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="299" mass="33442" checksum="202A8AD49C2655D0" modified="2017-04-12" version="1">MGNTLSAYSQPDGTAFDASYFRPVCPQAKFSRGAEKDVGKESYSEDCLRLNIWTPAEETGAMSDKKWPVVLWLHDGWFQLGDPFQGVGMNPTELISTGKLNAIVIGIGYRLNVFGFLAGEALLEDSHGESAGNFGQWDQRLAMEWVNENIASFNGDLNNITLGGRSAGAYGTHARDSQPFHRFYMYSNAIPPQLKALSDVNSQFDELCEYFKVPEGLSGPAKRFTRYNHSGAFAKEFKKQRLRILIGQVLNEETLYAKYNSSEPNLESLRLQVSNYYAPETADRVIKEYKLPSTDNPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T895</accession>
    <name>A0A1Q5T895_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T895"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11299" checksum="5A5C235F3AD20A5A" modified="2017-04-12" version="1">MAADEILRHSSAGAGILHRRPHTIPANETTVFLLVETLAHSTLWINLDDPARFLYVLFVLSTPKPKHPSPIVALDIIPHDLRPTFITIVALGLGVSFTEWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8D5</accession>
    <name>A0A1Q5T8D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8D5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8D5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="240" mass="26715" checksum="AF6F25C2A595F802" modified="2017-04-12" version="1">MKLTQPSPPQQSSTYGGDKKKKGFCDIEKGQDWMSNYYRRKQYHKEGCGLTCECISEETGKPGLKKQKEEGDKPKDPEVKCVNTAYSKAVSVDVSLMRMLANKFCSGDKNKKRSQDLTAKDVSSSAYKYYKFHFELDPGKNSKFDCNAVFKSITGKCQGYDSHSIQSQGGAKIDDCGASFSYKITVPDKPKPKPDTVTQHGLQPRKCHTKDQFGSHGDVRGGELSMPRLDVLGSPMTRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAK0</accession>
    <name>A0A1Q5TAK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAK0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAK0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="280" mass="32040" checksum="0B0E378629F5D479" modified="2017-04-12" version="1">MSSCSANGDPLTDVDVKLKVWIRTRWLHFRDEIAGNLITPLRWEIARDKPALVQALLEAGAEFPKIPDKNTAKRTQLAKSWPSEHCDVFELDQPCYNIRIIRAFLDRHGLQKGQAPFAETPLGLIAMDPDGPARRIRMVNYSHPDTLSSLLSLLRQYQSIDDAVLFWAAVVNNNEDIVRYLVRNGVDVELRYQGMTPLHTAILHSRVNIFEFLLENGTDAGATTSKRRLSTLRMLFWTVKPRKTESMMLDILLHHLGGSIVPYCHTRPSILWLARYTWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAK5</accession>
    <name>A0A1Q5TAK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Exodeoxyribonuclease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PENSUB_10068</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with the MLH1-PMS2 heterodimer via MLH1. Interacts with MSH3. Interacts with the MSH2-MSH6 heterodimer via MSH2, and this interaction may increase the processivity of the 5'-&gt;3' exonuclease activity. Interacts with PCNA, and this interaction may both stimulate the cryptic 3'-&gt;5' exonuclease activity and suppress the 5'-&gt;3' exonuclease activity. Interacts with WRN, and this interaction stimulates both the 5'-&gt;3' exonuclease activity and cleavage of 5'-overhanging flap structures. Interacts with RECQL/RECQ1, and this interaction stimulates cleavage of 5'-overhanging flap structures. Interacts with DNA helicase ZGRF1; the interaction is increased following DNA damage induction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="23" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013089799" evidence="23">
        <location>
            <begin position="22"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="21">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="24">
        <location>
            <begin position="80"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="298"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="422"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="547"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="613"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OKO97274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="679" mass="75512" checksum="5C3DB5FF6A0DBBB3" modified="2017-04-12" version="1">MGIKVRMLLFFGVTPYLVFDGDNLPSKAGTEQDRYRRRQESKALGLELQRKGRLPEAYQEFQKAVDVTPYMARQLIEELKQMNVQYIVAPYEADAQLVYLEQQGLIHGIISEDSDLLVFGAKRLLSKLDQHGDCIEINRADFTACREVSLVGWSDADFRRMCILSGCDYLANIPKMGLKTAYRSIRKHRTVEKTLRMLQFENHLQVPADYLANFQQAELTFLYQRVFCPNVKKLVTLTAPEDGINLDELPFIGADVAAEIAAGVACGDLDPTTKEPIELKPLAPGKFSRGIIRRQTLGSSSELKPTKPISSIFTPKRMPLGELDPNSLTPSPSQQLLLERNANSSWQANSAPYRSTQNRSTPFRALSDQIRSPMVRSVERNSFLAQAAKASTLQPIKRQRLCSETEDDQLPARPDFRSRFFASSADQASPSGQKVSRTKKQRKSTLDVFSDEVAEDIFSGMPDPGSKQDVEDATETPIKTGGAPQADAEGGEASPSIPRTEDSTVPPQDETQTLNEPSENRDFDQALDYHVQRQNSTILSKYTFQAGSKAASSRPPMTKIPVFQSGNNKPTPIASPRTPSIAAQNRAPQRQRLTPLQRMGQAALTRSQTINFPTKLRQADSMDSQSDGESLLAPRSSTHKVQGSEDLIVPDSDEDEQEDHSISAQTIPLDLKRFSFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBN1</accession>
    <name>A0A1Q5TBN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBN1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000098">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="19432" checksum="46F267A0EA5B95B4" modified="2017-04-12" version="1">MAGPSSNTTQRLLRELKDYAKSPNENLLHLGPVNDEDILRWEAVLKGVNGTPYEGGLWHLRIAIPSNYPLAPPTIHFTTRISHPNISFATGEICLTLLTTEHWSPVYTLSSTLTAIHQLLTDPQPDSPLNVDVAALLRDGDIPAWESVVRYWTGEERWQGSAAVGRIDTQLWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBN2</accession>
    <name>A0A1Q5TBN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="358" mass="39588" checksum="7352BB6C86DE2752" modified="2017-04-12" version="1">MEPSKASAYSRHDQNRIQCADAKSLFRYPGSLLLNLGAFFLPALYGTLSKLWVANIDSSQVVLTDVYTYIGIVAEVLNDAFPRSAWNVIGDKSTRSVRSRLNLAYTLMIATATQGFTLMVIFLGYPQGLASAFVPEEVRGISLTYVRLSSVQFLTSATEAALSSSTRALDNPDVPLIFSSAKFIINIVLDLLIISKFHVTEAKPTIVSQAVVRLVCDVVSVLTGLLYFSLVVVRKVQKEPDERQHLSIGLSAFMTLLKPSVYTFTESAIRNAIYLWLVNRIVQMGETYATAWGVFNTIRWGLVMVPVQALESSTLAFVGHAWGAFRASSDTTHPRASRKEILSRSITEGKWVTTDWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBP3</accession>
    <name>A0A1Q5TBP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Blasticidin-S deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBP3"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="131" mass="13723" checksum="9DE051C0FDADDBEF" modified="2017-04-12" version="1">MDLTPEEIKLVEVAKATIQSISTSDTYSVASAALSADGRTFSGVNVFHFTGGPCAELVVLGSAAGANAQKLKTIVAVGDDGEKGVVLNPCGRCRQVLRDLQPSINVVVVKGGKLKSISINELLPYAYDTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBX6</accession>
    <name>A0A1Q5TBX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBX6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBX6"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002614">
        <property type="entry name" value="Origin recognition complex subunit Orc5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="319"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO97680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="531" mass="57393" checksum="EAF59D52579DA926" modified="2017-04-12" version="1">MQPVEVARSLSTQWPCRDLQARQLASLLHPNTPSLSTLVVHGVSATCKSTILRGILSTLEVPHAFVRSSECITARHLLTKILWSTLEALGQKDEWEKYGKGRCEHVSTLAVLLEECLAAGAEERGGKFVLVLDEIDRQREAPPTLLSALARLGEIIPSLCVVLVLSSTPRPLFLQNAAVPHVSFPPYTRKEAIDILLAAPMPFVENLPDETSSRVYPHFVATIYDTLVGPTAGSIPTFRSICHRLWPLFVAPVVQGETPPGGNTEWDFTRLLVKNRALFRHQGESALVHRIVPEDTSAPSKTLRKPMATSAAPSALPHLPYFSTLILTSAYLASHTPQRLDTIFFSKFSSSSLSARNKRAHHRRRLKVLSQAQAEDRAAANDDPSTPRKGKRTKTRITKSTLSNAFATSSATTSAVGGGAGITGPSTILSARPFPLERLLAIYHAVDPNPPENPIHTAAVADQIYAELATLRRLRLVVPASGHVGFASTGSGNTSADAGEKWCVNVSGDWIGELAKGIGVEVGEWLAGGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC58</accession>
    <name>A0A1Q5TC58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="94" mass="10246" checksum="D8D681DDB0BAE062" modified="2017-04-12" version="1">MATDELLLHSVTFVASIFIIGVRTIQLINTRVPGNSVTRTQIWGMVRFGADYLVSDDEHLDVEGSFAWPAAWASQSIFAGMGSSSRGEAAKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCQ1</accession>
    <name>A0A1Q5TCQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_9577</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCQ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCQ1"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="64"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO97997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="411" mass="46491" checksum="5DC525830C895602" modified="2017-04-12" version="1">MSPISKSDLGLEDAAGNGASQAENSPSRALPASWYTSPEMFELERRAIFSRKWLLTSHTLRFNKTGDWLRYTIAGFSFILVRDKEGAVNAFHNVCRHRAFPVVTEDGGTSRIFSCKYHGWSYGLNGKLAKAPHYQDLNGFDKSKNGLLPIHVHTDVNGFIWVNLDGSEKPEISWENDLKGIDLQPRFKDFNFEEYAFDHAWELNGDYNWKILADNYNESYHSVNTQNDSGIHDPDTTQGLKSASTYYFPNASMTISPNFFFLQRFVPTSATTCSMRYEVYRKKDSSDEDFEKISSTFQQIMSEDKDLCENTQKNLNSGVFVSGELHPRLEKGSLYFQNVVRELVTEFHEREEEAGHEIWPSRQTLPSGDKTSQEDIDFCSKLQKAGDCSTQVSGDCGGVAACHSSNPALAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCS4</accession>
    <name>A0A1Q5TCS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCS4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCS4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65097" checksum="C5727B5AAC3B1B9D" modified="2017-04-12" version="1">MATNSDEAVYPQHIPYWRLMTDQGFVTQEIIDYPYAGSGTEQDPFVMEWIPNDPRNPMQFNPRIKWLYTVIVAFAILAVSLASSAYAGSISEVLKDMDVSEEVATLGVSLFALGFAVRPLLWAPLSELVGRQVVFLITFMALSSFCAGAAGSQNVWTLIILRFFAGSFGSSPFTNAGRVIADIFAADQRGLATSLFAGAPFLGPSLGLWWVDSLVKMPAGAGYRETYAPVLLRKRAQRLSSITGCVYRSKMEIDRGKVSAREAFSAALSRPWILLLAEPIVLLLSIYMAFVYGTLYMLFDAFPIAFQEIRGWSEGIGGLPFLSVLIGMMVAVALNMYDNKCYIRIHKKHHGFAPPEARLPPSILGGLAIPIGLFWFAWTNSPSIPWIVCVLATAPFGLGMVLVFLGIMNYLIDSYTIYAASVLAANSIIRSCFGAVSPLFTTYMYHNLGMHWASCIPAFLSLACVPFPFIFYRYGPAIRQKCKYAAEADAFMRSLTKKAYDQDHEPEKEIDVEPITNVDESKDETADSNEIARESASISSQSTLERTETVYDANPYDIDHVNTHNSAITQTSRRVKSRWNMFSFGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCS7</accession>
    <name>A0A1Q5TCS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic spindle checkpoint component mad2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="186" mass="20798" checksum="8A5142CFC2D2084A" modified="2017-04-12" version="1">MPETKDKSKVHKLSIRVSADDQVKAYIKKIMSQLNKWMAGGKISKLVVVITDKETGEHVERWQFDVEIFGKSSKSQSSRKAGDKENTAPGENEAPAPEPVEKTEKEIQEEIQAIFRQITASVTFLPVLDGDCTFNVLVYADADSEVPVEWGDSDAKEIKNAEKVQLRSFSTNNHRVGTLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD18</accession>
    <name>A0A1Q5TD18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000678">
        <property type="protein sequence ID" value="OKO98116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD18"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="9089" checksum="1FD192A6954F4114" modified="2017-04-12" version="1">MSEDASLMAQANEQLKRELLQSQKLTLTTYRAPRRVVSLGISPSYVKDWVPADAFRELYQNWYVLASSAGQTLINAGRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDG8</accession>
    <name>A0A1Q5TDG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDG8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDG8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF600">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="137"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="323" mass="35244" checksum="242593256356097E" modified="2017-04-12" version="1">MATPTPLPTRADLAKKATRYRLFAGILSWLDRYLSWPLPTRPALELTIPSTTSKTPGVIQLYFFTGTGTLLSPGEDEEQPHAKRPVLINFHGGGFAIGHPLDDARWIAAVLHAHPDAVVVSVGYRLAPEHPFPVPCAGGNLCLTVPLRLREEIIKRREHQRESPGIKLAGLIAFYPSTDWSRSRIERDATNPTASRKSMITADMFKFFDESYLMQENLPRKAGTDEIDMAHPYVSPGLADEGLILASYPEHVAIYTCGWDQLLVEGNAFRERLRGFVGVGGLSLNPHLSTKFIMSGHAGCPKCSAPIEGGTKTCGSCGAACPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDW2</accession>
    <name>A0A1Q5TDW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDW2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044393" evidence="1">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="9012" checksum="60BA27D09C4AD3C4" modified="2017-04-12" version="1">MHVPYLFASFVAAGIALGLPVPGNDQLESASEEVDKRFYYTHYEAPEKRDENLDKRFYYTHYVAPEKQKRDEEAVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE34</accession>
    <name>A0A1Q5TE34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Laccase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE34"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012750375" evidence="1">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8720" checksum="A8E68335BB30DD33" modified="2017-04-12" version="1">MMPSHALCWALCSLLLPGLTVGKLIREEITLTWDLGAPNGHVREMIKMNGDFPGPSFVWEEDDDIEVIWSAALLRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEG2</accession>
    <name>A0A1Q5TEG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEG2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="68" mass="7872" checksum="82A3FF84AB4D11A7" modified="2017-04-12" version="1">MDQPAEPNTAAMHNVQRRRGSVGTTQLFDNIVSTSNFDRDEVDRLRKRFMKLDKVLRCFPKTGDSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEU8</accession>
    <name>A0A1Q5TEU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9009</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEU8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEU8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012343775" description="TMEM205-like domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13274" checksum="EA3511A2AEB71B6D" modified="2017-04-12" version="1">MGGIMHAVGSLLPYHLLSYGALLGTEVYQSFVNTKLCFQALPMREFLALQKRLFPVYFKCQVGLAVLTAATHPPYSLFSLVKDPWGALPLVVVLITGSLNWFVYGPRTTTASLVRRALGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEV5</accession>
    <name>A0A1Q5TEV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEV5"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="231" mass="25676" checksum="1873E0432FDEE88F" modified="2017-04-12" version="1">MASIRANCRKIMCIGRNYADHITELNNTTPKQPFFFLKPASSILLPNSGPVLRPKGVSLHYEVELGLVMGKTVRDLDPEDEQGALDAIESYVLAIDMTARNVQEEAKKKGLPWSIAKGFDTFLPISQAIAKSRIPNPHDAFLRLRVGETERQADSTSLMLYRIPQQLAQISRVMTLEKGDIVLTGTPKGVGEVKAGDVMHASIEVNGKEIEEGRIQVEVQDRVGRYEFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF54</accession>
    <name>A0A1Q5TF54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centromere protein H C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF54"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF54"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="10">
        <location>
            <begin position="62"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="170"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="29338" checksum="D523D581645C48F3" modified="2017-04-12" version="1">MSDSPPPSAHITRYTPTRPRDPSMATKQGSVRPHLLSNELALLDYAADDVRDIVTLSDKEALVLQLAGQVQEQQLEKALLEQELESLSGDNVEEELAIAEREFLEARGSYTVRRKAARTILMTDPILKAVHLKATTPPERALLRLVNRRDVLALAQENLASAHELVLKQLSDAEVENLKINQENQELVRELLELTKQDSSWRERLQDADLASQLDQLEAELKKSKAKWETMKSIASAMVVGSGLDWADDDTLRALVLEESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFK7</accession>
    <name>A0A1Q5TFK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="36115" checksum="0C0984674D818B1E" modified="2017-04-12" version="1">MRIYESMFEYTSKLSWQEVREVAKEFLPSLQNLTPHLLTEMEGIAEGAEVDILDIVALNCRSEIALGKFSDGCTTLCWKKSDNVRVLSQNWDWTATVKKNLAMVSIEQPDKPTIYMVTEAGIIGKIGFNSAAVGTCLNAIRAKPMISSKLPIHVALRLCLESTSVAEAVDTLERLGGVASAQHILVADSTTALGLELSPVGNKYIPEDASGLIGHTNHFIENRYVEEPPWLSGSPIRLKRLSDLTKELISNGVKGDAISPALLREQIFSDSYNAPQAIACQEDESRHISTRSSSLFNIIMNLDTQNLGAEVVWGRPCSGEEGPVLKMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG73</accession>
    <name>A0A1Q5TG73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG73"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="314" mass="35885" checksum="AF30BC98F3700F28" modified="2017-04-12" version="1">MPFSHHSHSGQFCPGHAKDSLEEVIQTAISKKMQVFCLTEHMPREEVDFYPEEIEAGQTEAWHSTNEEAYFTEALRLRKKYSSQISIIIGFECDWIRPSSQTVIARSLSRFPFEFFIGSVHHMHTIPIDYDHEMYIRARDIAGGTDERLFEDYFDAQLDMLKALKPPVVGHFDLIRLKSDDPERSFKTWPGVWERVVRNLEFVVGYGGLVEVNGAALRKGMSEPYPKGEICEELLALGGRLCLSDDSHGVDQVSLNFHRVLEFLDRLGVDKLHYLSLVGEEGGDLSAAPDERFPRTRVAAVSMEEVKQMAFWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGP3</accession>
    <name>A0A1Q5TGP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein brlA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000659">
        <property type="protein sequence ID" value="OKO99413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGP3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="158"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="257" mass="29381" checksum="22B9FFD97F7C7E3D" modified="2017-04-12" version="1">MHSQVKTAPPSAENRDYHTEWNLSYPSQGPYQWPILQAGHSPVAVHWIGFLGNIWPSMEFSIYASAQQAQPQDLNWSKDDTDQKPGVQFFARNPTAESLGVTMLNRSDIALFGETPDSEWRTTSWHDFEEFTRPICGNQGYSSRSRNSIPWQIQRRQFKCSVAGCKGRFRYFKGLQRHLSGHLAGKPHFCWVPGFRRSFSRRDNLKAHYATHGKHGGRNRYVATLDRTSSAYDPCFRGQLTSDGWPAREANMGLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH02</accession>
    <name>A0A1Q5TH02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exosome complex component RRP46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH02"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH02"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000036">
        <property type="entry name" value="Exosome complex subunit Rrp46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="26552" checksum="72BF6D10BF01DD7D" modified="2017-04-12" version="1">MVGPTASLSNLSRADGSASFKCPTTGCSVLGSVNAPIELPARRDALKPEEATVEVFVKPGNTTAGVGERYVEGILRTMLQKVILGRERGFARRGVVITLAIIGGDAVERGDSYLTLLPTLLQTALLALLSAAVPMSMTFSTALLAVTKSGDIISDPCPVDAKTASSLHVFAFSSKGHLLLNESQGRFDFDTWEFVRERAYSTCRGAIVAGSDGDIAMGEEGEEGRANGFIRETVEDHLHRDYAWKIDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI13</accession>
    <name>A0A1Q5TI13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="163" mass="19518" checksum="6439662BC820F4B7" modified="2017-04-12" version="1">MRLEDTLLEDEEADEVTKQIYNIIQSEYPLEEPDHKRHRTALELSPEHILRRKRDPTETDEEYLDRMERVNTWPAYSTAAEAKWIWRAQVVIRAMKFLCDYAGCDSFRPKVFYEYSWICLREDIKKRFLQNGTKAKSLKFSPVKFAYKISCHKPRFSASDQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJF6</accession>
    <name>A0A1Q5TJF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="10496" checksum="013D133E598171A1" modified="2017-04-12" version="1">MSDSNNSLSTDSSRDSNGDGVLTSVQQQINSITAGASATRFQQNVTALASEKITDVKEAVVDNIIPAAGEALQSAQESIYTLAGKVTTGNDLQGEKGPGTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TNJ6</accession>
    <name>A0A1Q5TNJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000633">
        <property type="protein sequence ID" value="OKP01801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TNJ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="74" mass="8140" checksum="25A5934C74630E52" modified="2017-04-12" version="1" fragment="single">STVMDLDRFRGEHLEFDQTVNANVMEATVALVRCCNDQALELFGRRQAVAVAALNDGIVEVLKASEKRAYGAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ40</accession>
    <name>A0A1Q5TQ40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ40"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="784"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="983" mass="106367" checksum="9DCA633BC7852E1D" modified="2017-04-12" version="1">MDTVDSGSTSEIDDQSKTWGSDARTIVSQGADDASSAHPHSDCGIGHRVLASRSVLALVIDEECVFAGLQGGDIVAWSLETYDLILSVHAHEESVLGLYLSDDGNLLFSSGGDSVVNVWSTRTFERLYSIYSHHDVGDIFSVVYSSSNQTIYCGAQNTSIQWCNLSEEGSLNQTSAAHPSKRTHRFFDSRGPDGTRAPRSSDGANAVSEGGRVLTFKRDHHKLFAHHGYVYSMLLVKGLIESAPSEEALLTGAGDGVVKLWRLGQEPGSAPTQIAKLQNGDSVLSIAVEGSLLYCGLAGGALNIWNLDSQQLVKRIARHTGDLWAVHVIQGVAICGDSTGTVKKFNSRFEEVGGWTAHQGTMLASAVGRVKDRQIYATGGNDNSVGIWDLTEFFLAQEELPPISNDEMVNSLAKFVSFKTISASPKFTGECNQGAAFLRRHCNYLGAKTKLLTTGEDTNPIVFARFNATSTEKVDKTILFYGHYDVVGADTNRPKWNSDPYQLTSINGFLYGRGVSDNKGPILASLYAAADLARTKSLRCNVVFLIEGEEESGSQGFHQTVREHKAQIGPVDWILLANSYWLDDYNPCLTYGLRGVVHANLVVTSDHPDLHSGIDGSALLDEPVKDLSILVSTLVGRKGKINLPGFHDPVRPLTEAEQKRFEAISDVLLPQHPEIPDSQALIKSLMYRWREPSLTVHSMEVPGSKSGTTTIARKAKASLSIRIVPDQQADEVAANLTAFAQEQFDLLDSQNELTVEITGKSDAWLGDPDNEIFATLSEAITAAWTPDQQTSKHQYPVPKLTPGRATPNPKPTGPASQLLRKDSSDSLASHVDRVITSTTTSSGKAAARKRSTQGTAPVPTSNTLAKSASTPSLDSSSLPIRAKSDSETESDSPSPSPSATKQETQATSTSSAATTVKPIFIREGGSIPTIRFLEKEFSAPAANLPCGQASDNAHLDNERMRVENLYKSREIFRYVFAHLVDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQH3</accession>
    <name>A0A1Q5TQH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQH3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQH3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43358" checksum="5BEA1ED932D6E471" modified="2017-04-12" version="1">MDEINGMQETSGFIYLGYDIEALLSDQSEPKTSREEIHAAIRDLMIAIGAQSCPDEPENVQIERFFVERGQRRAFANMLEDPSLDLLSLIVDEITNCLYSEKAASIEKAGLLLAKLNRWSDQLPECLRTPSSKNEDSDAVQERIIGNMHVACSYHFAVILVTRPFLISALSVRLARVHQAFSSDGASELLEEDPAHSRLAAACIDSAVYMLQTCKEIHQSELLLRQMCLLKAFVFAAALVLGFSMFSHRDVDTEIDNAFTGALSILQMLAQQSAQAAHYLEILTLLQAAVTQQRHRLSSQARQRRSQYVSRIFSLSDTPSTPRVQSVDNGRAGSATPLLVQGGPFYPWIQNDEGAAIAMPPIMDGAFLDWEGMELPLWDSFPFTEPGSSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQJ7</accession>
    <name>A0A1Q5TQJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQJ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="12">
        <location>
            <begin position="87"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="229"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP02491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="36144" checksum="95CA9B0F53B97FAF" modified="2017-04-12" version="1">MTKHVHGAPANLRNCSTPPSSRHNSDFHIGFTRVRHIFTILTTREGHHVFLLKIPELPALVSAPPSARDHPPNKHSDYTPTKTSSCIAHRSTILAEHSSPGSSSTAASSLASIILPKITHDKSQKLTYTHERLFVHYIADSPAGGAVDDQSGRTEPDSYAPLSFIVVASAEQGRRIPFAYLLEMKRKFLTTYPPSSTDYSALPAYGCAAFNSELRSLLHTYNTSPPADSLASARREIDSVRDIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRIRSRGLRRRMWWKNVKLMVLLGFVVVFLLYLFVGMGCGLPAWGKCVGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT58</accession>
    <name>A0A1Q5TT58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TT58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="4">
        <location>
            <begin position="292"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="2">
        <location>
            <begin position="292"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="2">
        <location>
            <begin position="427"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP03381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142452" checksum="51DA4C608ED4140B" modified="2017-04-12" version="1">MAAAYAAGRVTLEEAIVAAYYRGKSVARITREGSMAALGLTPNDCETLLEPLKDRVSIAAINSPESITVSGDTDAIQEVSNICNSKGIFNRVLSTGGKAYHSFHMREIGEIFETSTRQAMSHIYQEEGRRAVTPFFSSVSGHRLPEGSQITPSYWRSNLEGPVLFSPALEELVNYGVDLIVEIGPHSALAGPIRQLEQAFRGKEKVFPPYMPTLVRKRDAEECMLELAGALFNEACKLNIGAVNCAVEAATGKEITPRLLSSLPTYRYAYGDSLQHMSRIETEFRFPQFSFHNLLGSRVLGASPRAPSWRNVINSDSAQDVGGLRVLQTAQIPVACLLEMVLVAAQQTVPSISARTWTFTNIQLPNALTLEVEKDVVTCLYPNVDEGSYLFEITSIQGREAIVHAAGQIHAKQDQPIQGSILDGRITPITISAAKLYKKLEATGLQYDVSWQSIETVHANPLENVYRYELRETSLSRLGTLETCIQLAIMSSVTHQQTHDLQLAYPVSIGEVVITGFWDNLDMSTPYLASTIQSRDVVKTVDLWDTNSQLAICLKDVRLNHLDCRIIKPTEYPALQSISKPDYTTISQDSISGIFPAPVFPGERTFTKVHRLASAVVVQYISSQTESSSNKTSESLSETGRNFFDWLENAYAQIPNGSMPYGQELAAMDGPARSKLISTLYEEVYQDSVEAQLMMRMYTNLSCVLDGTVSAHDLLMVDGLLHKLYTSTLTAAGSMIQLRRVIDLVGHKDPSARYLEIGGGTRGATREILDVLGAWGGARRYGSYCFTDVSSYFLSGARDEFQDCQDISYATLNIEEAPSKQGIEEASYDVVVAANVFVPWLLTIETVWLTIVLGGFSDYWKGRRDDRPTSPFISVDLWNQTLQKCGFTSAWIDLPDYADPFRTMNVLVSSVADDSMNGHAESADKGLIERFYPMTPSKHMEGASLNAQSYSNSVVLIDCIGEPFFADLTIWVVAMGIRGIIIARSMSTNTDDNLIDELILSHLENLRQLGIAVSVVWEPLLNVHQDRISMQLRATLSPRVKAVIFGRPDASIVMEDLHGVAQHAFSGRWAPEKVLIITSADATFFDLPARRSGQAQCIADSWAKQGPASSLLTIFQDQPTFDDLIPGIEALFCNSNAPASDSLELCYAQSIVSGLSSANASTLIHERQTDVPPQTLDKWAIILQTAAAQAQSASANTTNGQGATPTSTAIAKFRSITIEDADGRRNSATAAVAEVLAELLFIPKEQISMQASLARIGIDSLIASELRNQVDELFQKEISTGWLLSGEVTVADIVDIVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U043</accession>
    <name>A0A1Q5U043_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-cyclopiazonate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U043"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U043"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF26">
        <property type="entry name" value="FMN REDUCTASE LOT6, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202780" evidence="1">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="464" mass="51378" checksum="3E4E599D23193752" modified="2017-04-12" version="1">MVATVRLLAFAEVTIVASSTVYNFDATHYDAQDVITRDVAVIGGGSSGTYAAVNLQALGHSVVLIEKEAVLGGHVNTYTDPTTGVTVDYGVQAFWNSTTTWDYFKLLGISGEPYSIAPLTNAFYDFATGTPLMVKTANNFTAYAEQLDKYPYLAYSWNLPDPVPEDLVLPFQTFVAKYNLSNLAYTAYFYSQGLTNFLQQLTINVFKMFDSTLLSGLAGHDVVPPNHNNKLIFEKGFDRLGSSNVLLSSTILAAKRPTDETEVLLVAKTPTGNKLIVVSKLVISIPPLLENMQSFDLNEKEESIFSQWTYSSYYTMLVNNTGLPSGYRFMNANSSTATHNIPELPAPYQITESRIPGLWYVWYGSPSPLTQAEIQADVANIIKRLQATAPIYSPRPSPEFVEFRSHTPFKLEVSKQALQSGFYNRLNSLQGERHTWYTGAAFISQASGILWNYTHSLLPDIIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U072</accession>
    <name>A0A1Q5U072_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U072"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="31"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP05866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="558" mass="61238" checksum="6F8A1CE63DED7BC8" modified="2017-04-12" version="1">MAGGAKKPVNIFRLKNLGEPKEVFNWKLWFAVVSFGLMGAARGIDEGLISGAFNSKDFQRYINYSSYSTVEQTNIKANVSAMVQIGSVGGALFAFLVCDRIGRIWATRQLCLIWIIGAAIFMGNNGNLGAVYAGRFIAGLGVGQTVVVAPIYLAEIAPAAIRGLCTCVFTGFVYLGIVLAYFANYGCQVHMGDNTHKRWEVPTSLHVIFAGLIFCLSFFQYESPRYLIKRGQFEKAITNLSRIRNLPTDHEYVVREITAIQTAHQIEMEATLGAGPLGIIKETFLIPSNLYRVYLALMAQILSQWSGAGSITLYAPDLFKLLGVTGSNETLLVTAVFGIIKLVAAVMCALFLVDVIGRKRALLIGITLQAIAMFYIAGFLTAVPEMGVVKNFKLPASKKGASEGAIAMIYLSGFGWALGWNSMQYLLTAELFPLRIRALATSMAMTLHFANQYGNSRAVPNMLLPVAEGGISPKGTFWLFGAITLIGGIWVWFTIPETAGRSLESMDRLFELPWYRIGRYGNQDAEERDQVVDEKMEAMTSQHGTSQHVERKDASTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B8</accession>
    <name>A0A1Q5U0B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-like protein arp5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0B8"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000048">
        <property type="entry name" value="ARP5 actin-related protein 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000025">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP05926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="753" mass="86835" checksum="7463F8454E2A6F33" modified="2017-04-12" version="1">MTITSVQTLLPGRYSVNVTEKRAEKPPPQTHTVQDYPFKGYQPPQTDGWERSKAHPDTSAIVIDNGSHLVKAGWSFDKKPRFVLPPVMSRYRDRKLGRQAHFIGYDAYVDATTRGQLKNAFDGNSSVVGNWDVMEGVLDYIFLKMGVDGANGGVERPILMTEPIANLGYPRRMMNEILFECYNAPSVAYGIDSLFAYRYNKGTDGLIVSSSHTSTHVIPVLNSKPLLSNSSRLNWGGVQTAEYLAKLLRLKYPTFPARLTDNQVEEMVHKHCYISQDYDRELSGYLDWTGLEERNHVIQYPFTEHVVVEKTEEELARIAERKKESGRRLQEQAAKMRLEKLVKKEQELEYWKDLQVRLATETKKEIRRVLEAEDLKDEAHLERMIRDLEKSIKRSRNRDLGIEEEEQQEEMSFHLIDVPNEELDEAGLKEKRHQQLMKSNVEARARAKAEKEREKARVEEEERLDREKRENDFENWIAARRANRQNLLQKIKDRERFKADLGNRKSLASQMRMKTLANLAADGPKKRRRGGDDDDFGANDEDWGVYRTVAKDEQSDDEEEEDLDGMLNNVEQELLEYDPEFTENHTLAAQSDWTKSLVHAFLRGPWPFDPESQREAHQIHLNVERIRVPEVVFKPSIAGVDQAGLIEIAADIVNQRFSNPVDRNRLLKDVFLTGGNTLFTGFEERFRRELRAYLPIDAELNVRQAADPVMDAWKGAAQWAAGADLGRSSVTRQEYLEKGSEYIKEHDLGNVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1C7</accession>
    <name>A0A1Q5U1C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1C7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1C7"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="16566" checksum="DD5F90FE6CAE0F2E" modified="2017-04-12" version="1">MASTSASADTSATSSSPKKYNLRNPLPLSASQEQEVKQMYYKRVRARCAPEIKAFAECAVNRTVTATWVCRQQRLAMNACMVTHANNREEEDRAREEWFATHEERRRAKEEELKRVEKRRAEVITMMRQDEERRRQQEQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Q3</accession>
    <name>A0A1Q5U1Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Q3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1Q3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="275"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="826" mass="92514" checksum="D90BF8226931B083" modified="2017-04-12" version="1">MLPTGKLGGVDKEGISETDPNTSPDDLAANKAISGSLEQTAALYDEHSTQHLLESGVSVNRSDHCQISINASIPLMYETGSRQALSPEFMSGINWLSPGQTIFQEWGSQLADITDNELFPPMFNMVDLPEMPTLFSAGTEQQVASENPGQLFSAHAQLGSWENPEGHAGVREPRSPETFLDGLSTGTSGSVESKYYVHGVASRAPFQRRSRNSWVVPDGSTSDLSTSASITGNIPTSIDHWLTLEVYSNVVLSIQEQIKTQPQIPPLEYFRLCVHLYFTHLHPNFPFINRVTFLSNEPHLVLCIAVAGAGAAYLQSPLGTQWKNSLMEILGTTLSNHLSHYQNIPQDASSMQLLDMHITMEMVDEVMPLIQAKILHMLFMLHSSTLYITRRAGFERAELTQWCSYLNLVSTSLGAPTLIKDATDVQLWVKAQSRLRAGMMIWLLDSMLSYESNCKHIMKLGDTAKWLPCHEVAWEQPSIANIEFAQRYSVSFVDAIDMIYIEKRLAPHLSEFSHVLLIHAIYRRTTEVVDESRMRLSYWSPTSRMQALVSEPNPAQEWPPSSTTASNWRNAACDSLDVLNWAANSKSAESCWEEPTILYLHLSRLILLAPIAHFQTLAKFPSLHTLKWPNSIPFNQYNYENARSQVLQWAIRDQFKARLSVVHAGALLWHVRRFSTDNLIEPFSVYIATLLLWAYSASICAVSNSSGPVRADQTSQNDDLAPDDSDDEPLWLRLDRPLDDELVQTYIRVGNKMSAHLKGVGDICKHDAPLKILKQGYYLLVGERYSRSTDNTVNESVPVETKHCTWEIRRSYGAIIQCLIDATGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Y9</accession>
    <name>A0A1Q5U1Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_6498</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Y9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1Y9"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="26"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="243"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="560"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP06508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="759" mass="81624" checksum="F4456AFA42814080" modified="2017-04-12" version="1">MADLVDHSPRHPTIAAKLSTASNVILIDNYDSFTWNVYQYLVLEGATVTVFRNDEVTVEDLVAKNPTQLVISPGPGHPETDAGISNAAIKHFSGKIPIFGVCMGQQCMITTFGGKVDVTGEILHGKTSVLKHDSKGVYEGLPEVLSVTRYHSLAGTHSTVPECMEVTSWAELENGSGNSVIMGVRHKELAVEGVQFHPESILTEYGRTMFRNFLKLTAGTWAGNKGSAAPKAAAPAEKKLSILDKIYAHRKNAVEEQKKIPALRPEALQAAYELNIAPPQISFPARLRQSDYPLSLMAEIKRASPSKGIISADVCAPAQAREYAKAGASVISVLTEPEWFKGTIDDLRAVRQSLEGLTNRPALLRKEFVFDEYQILEARLAGADTVLLIVKMLSVELLTRLYNYSRSLGMEPLVEVNTPEEMKIAVDLGSEVIGVNNRDLTSFEVDLGTTSRLMDQVPETTIVCALSGITGPNDVEAYKKDGVKAILVGEALMRAPDTSAFVAQLLGGSSEKIASTSTSSPLVKICGTRSEEAAKAAIEAGADLIGIIMVQGRSRLVPDDVALRISQTVKSTPRPGVQSTDSSEQISKTTSSEWFEHSSRVLRHPTRALLVGVFMNQPLSYVLSQQQKLGLDVVQLHGSEPLEWASLIPVPVIRKFAPGDLGIARRAYHTLPLLDSGAGGSGQLLEEAGVQKVLDSDEGLRVILAGGLNPDNVIDIVKKLGEAGSKVVGLDVSSGVETNGAQDLEKIRAFVKAAKSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U386</accession>
    <name>A0A1Q5U386_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-methyltransferase NNT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U386"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U386"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="366" mass="40558" checksum="0B1F5BEA44D03A1F" modified="2017-04-12" version="1">MLHSRLRPAPLRKASTATPTDAAPAPDFHDADRSSDFEESAEDLFGAFLPHLFPDDAPSFYGDPGQYLLYSSPHYGELEIMIPSYPGQDKKKSEEGAIGPEKKEGATQTNQAEDGRQLFAHFLWSAGMVVAEGVENASCPATENDSDAQKEAREIWSVDGETVMELGAGKSIESIRYNIQLTDIYHPGAALPSLICALANASLVVATDHPSSPALTGAIEFNVKQNLLKRQTSQQTAVAIQPHEWGTVTDSFSQSHKGTFTRIIAADCYWMRSQHKNLARTMEWFLAPGGRVWCVSGFHTGRAIVADFFKTALENGFEVERIFERDLVSRDKEGGEIRREWAPFREGEGPGNRQRWCVIAVLKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4K9</accession>
    <name>A0A1Q5U4K9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4K9"/>
    <dbReference type="OrthoDB" id="3796275at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="23986" checksum="3436A05219C2167A" modified="2017-04-12" version="1">MPRSAFHIGPKKLVESPAPKLEPGEYHTTSSALHDLEFTGDLQPWPGFLSAVQTMHESHTWRNECLGLTLRTRDPYTHGNIVVGDEHGVQGRFHKHFGDILNAIFKSQSKSIRFADFRCVQSTYSGIPDVILKDNNHHLKDVGELKVPWVPDHTIDDKIDFDRDLRKILAQPIMYMQNLGCVYGFLSNYKETIFLRQLVDDKACGGSSILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4V4</accession>
    <name>A0A1Q5U4V4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4V4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4V4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="14663" checksum="D523733E41921BF9" modified="2017-04-12" version="1">MARRACSACSACKKHKRKCDKRLPVCSLCDRTERACEYDETPKPPPSADEFEALQARITDLEARLSSARGSTASVVGPGPTPPSTASSPASTNHTTSSTRFPYAMFLDLLQTENNVLKEMVRQLEEGLNEDSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5G5</accession>
    <name>A0A1Q5U5G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5G5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9327" checksum="7949575B5755888B" modified="2017-04-12" version="1">MKTPLVTEVEIIYDRESASPLPTSVIDLTLTKEARRARSAPEALMLGDGLDLEDPMVSHYADTGSQLGMFVNELSMFLVMLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U823</accession>
    <name>A0A1Q5U823_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multifunctional methyltransferase subunit trm112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U823"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U823"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="15578" checksum="F0E43197DED354C1" modified="2017-04-12" version="1">MKVITANFVTCAVKECKTSAASFPLHFHDAELEQQELDFQPEFIRNVLPRVDWDSLRITANELGFPSLPETKPEGDALNEEQTLKDLHRLLLETQVIEGKLVCGNCGHQPWMLPPSETPNHVFNAVRGGSKKKEKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U900</accession>
    <name>A0A1Q5U900_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U900"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U900"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="447"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP08922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="778" mass="90155" checksum="B7F60625CE3A255B" modified="2017-04-12" version="1">MANQSSGKSSYTELELQRCFEIIQGDKKVPQAKCLGCLKIRAKNTTRQSEHVNKCTKAQALMDPETTTGKKQRLLSFCASQPSRSIDQLIAQVCFTGARPFNLFEQQEMRDLIYALSPTYQIPSRYRIADDLLDEAYNGLREEVLKELRRTEFLNITVDETTNIRSQRVIVMTITTPTKSWFIHLNDMEDKTLDAPAISSWILNRLQCLLLQLDKIADWKRINSISTDTCCVMKSVWEKLEQTLELRHCIMIPCDFHRLQLIMKDIVDLKNSKVPRAGSVFKQALEIVVFFQHSPLEYARMQAKQLEKWGKRKALIASVITRWGTQYNMLSSLYDSQEAICEWAVITPAASTARGREIIRIANSHSFWWQLKELIKVLKPLHVAQKQSEAQNSSIMEVTQRWLNLHEDLRTLANQTSLKDDFLSYLDGIGWQSRILRQLEPIHWEDVAPLLAPFARRLCNTVANSAAAERAFSQMNLQHTKVRNRLEPQRVEKLLFVQINKRQFRAEQPPEVAQELLLQEEDDEVERVLQRNQVLHDLSEGSDQHQEQHHEEPPEQPPEQPPEQPPEQPPEQPPEQPPEQPPERSPDQPADQPSEKSPEKSPTSALVSALNSALNSASASTNPALVSALSDAKRRIHLDLEMYWYGLQRRNVPLLRHARRHFIQHAYQSWPMVSAQVIRMLFHDPRFVLLGELKEYAVRVARDYICRRGRGSSRLTKLCCDRIAMWKQREFYLMLQEELAQTWVTGKYGAHRPANTWHRYEERYRSDLAGIDTCNDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA79</accession>
    <name>A0A1Q5UA79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000525">
        <property type="protein sequence ID" value="OKP09377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012095411" evidence="2">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="143" mass="13936" checksum="AA67EFE021807AD7" modified="2017-04-12" version="1">MQFFKSILLLASALAPMALAAERVAAPSATSPCVTSTITLVPSGYTPPASTATPTPTSTPTPTSTPTPTSTPVSSSSSFSRVSSSTPLIKSTSTVVEVNTATAAPEPASTSASASAHANGASIRQVSGAMAAGVVAVAGMLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAA8</accession>
    <name>A0A1Q5UAA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAA8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="410" mass="45355" checksum="9C554BFC0F82C4C6" modified="2017-04-12" version="1">MWHNSEPSLSSVLLRSRSTYKHELLVGNLAGIPVAQQHGAADDNVPAYHGRLMHELLDQAQWPSEYKELPGKGHWYKGVLTTEYLKDFYRSMVSRSRTAKVLPQTFTITVPASGTLGSKAGIQVDQLQTPDVNGKFRVNRSPDNKTWHISTRNIHRFHFSEASSLVELPETIVLDGMNGSFEVHFAQKAQTWLVRDAEGKWEISHDTRWKTVHQRYGRQLGALDAILRTQGTFTIRGCSPGVDSVALQISRNLFQYFAADSQIIESCSNNTLQHQPGNVITLAVGHDLPPAPMETYPIQIDQGRLVISTSGSLSALPALREEYVFGEPGLGAVFLRPCPGETLELVVWGTDLDGLRQAARLVPTITGSGQPEYVVLGDSSRWEGVAGAYAAGHLDWSWQISPSSYQSDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAE2</accession>
    <name>A0A1Q5UAE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19401" checksum="A866E7B1B2D61052" modified="2017-04-12" version="1">MEAIGTVASVFAIYNQLEQCGKRLHQLKHNFRVAKQEVNLLADEVSACQGLFGIFRHISHPLESRVMQLARTQSLEKILKSQATFAFDQINEIVLKLEPLKKDTNASGFDKFIAKLRWHLTKDEVQAPLIMLSSVKISLTALTCLLVLDCSVADLRRPSLPESDKELIILQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAJ8</accession>
    <name>A0A1Q5UAJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000509">
        <property type="protein sequence ID" value="OKP09504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAJ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="15796" checksum="E46826E44FF424BD" modified="2017-04-12" version="1">MFDPGIGHLIDGPKIDSPSNAITLTLDYHRLFGEFQIYFQSTGIPHQYRINSTEQSPFLRDPLFPVTRDLTLSPTHTIDPPSSRLLDVHRAIALILKLSGAGEYIERVLRDMEQLDISEDGSTNLGSLAGLRLGGWLTLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAV9</accession>
    <name>A0A1Q5UAV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAV9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="7040" checksum="8A8B999D868D1179" modified="2017-04-12" version="1">MSVNGGAMVQEMVQEMPHTILSEGTSNYIRAAKLKAKLRQMFQREIKVHAELSSIIEDEHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBI6</accession>
    <name>A0A1Q5UBI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBI6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="238" mass="25434" checksum="781CE08A932DB20A" modified="2017-04-12" version="1">MAKSTRQAWPSLTPHNQTRRLEEASRPVAIDVSGNGKLPWPPSTQSADSPTLFHNITLFLTSETLSHNFTISNGTEPANNGTGYVGPVLDQEPSSTVKHVNWVWPKCLVGDGTSSDGSARGAYNISMHQSFRWNGSDYYTVFDLPISVTNSISESAERVDCASLENKLLNIAEVERSSDTLPGQPWVQAGASTETSTGSSASSTKTSAAAGVLKDKKKSMMLLATVGTAFSVFLHAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBN2</accession>
    <name>A0A1Q5UBN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NIPA-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBN2"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013089812" evidence="8">
        <location>
            <begin position="27"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="785"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="826" mass="89099" checksum="1966C5480771D22B" modified="2017-04-12" version="1">MGLPQHPLAVGLLTSFVSSTIAPSAATPYSTSYSTHTYSAFSNSTSQVPSGRDGDDEGNMERWSSLIGIVTALIGNVLISVALNIQRYAHIRITREWEQNKIKKEAERRRAHSGTSSTNPYGTVGGDGRSRSREQDRHNGRGQFEAYRDEEDSPPRGRHGTRGSRDSARDSFASDSTARPEDSDDRKSYLRSPYWWAGIILMVLGETGNFLAYGFAPASIVSPLGVVALISNCVIAPCLLKEKFRQRDFWGVLVAIAGAVVVVLSARSSEEKIGPGEIWMMITRWEFELYLGLTIGLIIGLMWASFSYGSRSILIDVGLVALFGGYTALSTKGVSSLLSGTLWHVITFPITYLLVFVLVSSALMQIRYINRALQRFDSTQVIPTQFVLFTLSVIVGSAVLYRDFESMSAGRAGKFVGGCALTFLGVYFITSGRVRSDDESTFSTDDEEEAIGLLHGERYRDRIDLSPPAQQFRAPKTFAVDHEEEDAVLSPTGSLTSRGIDGIDDDQLTPRGAHSGAPSSPAGSLTAESPLSGPSFDHASPLRPPSRMSNPWADSIDAPLETPKSDLETYCHTTPPAPEVDGSQESTVLLRFPPAPGIEEDSQNKSPVARRASTPTGLDHAHNTGSSHTTLETPSRRAMRNSISNRFSPGPLLPTLSGGFSAVVAESLRRGEASPLKDRARRKLGRRRQLEGAFEHDQARHQDGDLGVDGIDHPLNIATARLQSATGLGVPPGEAGQSTPALATEIYTPPTQKNDEDVGRLRSFSDSWSGGLAWLGGALRLSHQDQPVDSGAVTQGTASPQDSQGPTDADTHSHNDAGNTEADSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCP5</accession>
    <name>A0A1Q5UCP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000377">
        <property type="protein sequence ID" value="OKP10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCP5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCP5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="21060" checksum="A43A0448CF54282B" modified="2017-04-12" version="1" fragment="single">AVTAMMGDCQDLNLVFAWARRVFWTVDPADPEQFVEWPYPSEVRRKVAEFMKELAHCFDVSEQAHRKEHRLTGNKAHVKQNHADYNAFLVARRSELPSVPAPSPLDTKEEKAARFSKRPLRLLPGDEGYITWTLGKRAFFDGVSQVVREAQDDRDSDNDSNVSIGGDELEERTMIDFPLPLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD90</accession>
    <name>A0A1Q5UD90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000347">
        <property type="protein sequence ID" value="OKP10433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD90"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="7980" checksum="1BBC6B7D33E29D41" modified="2017-04-12" version="1">MFMFITILDTPMGMEISTRTGYEAYISELHKSNDDGTSRDPSTGGRLNMGLLRYLCVTAFSPYYPCTSLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDY4</accession>
    <name>A0A1Q5UDY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDY4"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="238"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="33791" checksum="02D9F7A3DB4A30CD" modified="2017-04-12" version="1">MEAPRNRKQRRAAAATMNTASGEPDIPLALPERGDPSKKSSEPTLYDIIEKRQKELLKQQESSGKAPAPALGKGMPSKTTGTRYVTVDASGNLVDADGNIESEISKNMGTQKAKRGRKAQAKDVNEEPELEIDKPLPPLLDTILLAIPLTTLHLTLAYLAAHQYAESINLPGLIKESIFITFPLLIFLVHFVHGHIVSFKLHTSLGFLAAQPVSVLPLTRDKFTLSFLRRLVFPPTLRTIILLPIAALLGAHLITVTNGEPYYAVMKKAPAYGTMWIWCILEMSFGPALLGALGPLIWGVYWMGYGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE62</accession>
    <name>A0A1Q5UE62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="20563" checksum="36DE08E8C7D21C53" modified="2017-04-12" version="1">MGYVGRHKAIPFGPYETPHRKNERMLCKRLQVGWTARNSKEVREPEIFAFAKELRGKYRRVGAIGFCFGGWAVFRLGAKTSGGLVDCISTAHPSWLIKEEIENVDVPVQILAPEIDPVFTPELKEFSNRVIPSLGLDYDYQHFPALVHGFAVRGNKENEAELKGLVRAKIAAVHWFNQYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEQ6</accession>
    <name>A0A1Q5UEQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEQ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEQ6"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase N-terminal" evidence="6">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="7">
        <location>
            <begin position="339"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase C-terminal" evidence="8">
        <location>
            <begin position="512"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="640" mass="69276" checksum="655781567AAF86B5" modified="2017-04-12" version="1">MSGNKFPVDLKQFKQLKLDPKSNTLTADQKSDLQHNINIFRDAIIAFTATGAARGVSGHTGGPFDTAPEVCILLAMINANPNGFVDALYDEAGHRVATQYLLAAMDGKIDPEHLLNYRDANSKLPGHPELGLTPGIKFSSGRLGHMWGMVNGIAMANNNKNVLMLGSDGSQQEGNDAEAARIAVARNLNVKLFIDNNDVTIAGHPSQYLKGYDIAKTLEGHGLHVVRAEGENLDSLYPAVAEVINHKGPAAVVINRKMAAGIEGIEGETHAHDVITVDIARKYLTKRGYSKEQLAFYDDIKARSNPHQYEGSTKDKGANRVIFGEAVNSILDGLSKEEAARRVMVIDSDLAGSTGLKAIGAQHPEVFIPSGVMERGNFSAAAGFGFGSNGERQGVFSTFSAFLEMCVSEITMARLNNCTVLSHFSHSGVDEMADNTCHFGLNHFFADNGLMDAETTSLYFPADGEQMKAVVSKVFWDQGMRFIFSTRAKVPYILKEGTDQKLYGEGYKFVPGKEEVIRKGTAGYIVTYGDMVYRSLDAVERLRRDGLDVGLINKPTLNVVDEDAIRIYGSTPFVLVVESIAQKTGLGSRLGSQLLERKLTPKYKTMGAVKEGCGGLYEQINAQGLGPDDIVAAVKEVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF91</accession>
    <name>A0A1Q5UF91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000297">
        <property type="protein sequence ID" value="OKP11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UF91"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012298871" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="919"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1298" mass="142731" checksum="D0FAA5F725A7DC03" modified="2017-04-12" version="1">MNWYAWLALVVASHLVHGTNAKAVFAHFMVTNSQNYTASDWESDMKLAKDAHIDAFALNMAWQDSTNDNSIKAAFDAAGSVGFKLFFSFDYAGNGPWSKDTVISMIQQYSSNGAYFLYNGKPFVSTFEGPGNADDWVEIKAQTNCYFIPDWSSVGAKPAAALANGVADGLFSWSAWPWGNQTMDTYTDASYFQYLEGKPYMMAISPWFYTNLPGYNKNWLWKGDSLWFDRWQELLGLDPMPEFVEIISWNDYGESHYIGPVYEKSMAAFNIGKAPFNYALDFPHDGWRDVLPFLIDLYKNGKADVTEDKVVVWYRPHPVSACSTGGTTLNTAQQLQIEFTPADGLEDRIFILALFTDGNHEVMVFSGGESSYYPTWESMPDGNGGAGLWFGTYPARPGKVAFELIYGDTQTGSLSGIDISSTCPQGFNNYNAWVGSFTGTLSDKATIFLEGDECIKGKGAYDFNDLCDFTCSYGYCPVGACTCEQLGSARTKPNATGVTGYPAEGRDANYEGLCSFACNYGYCPSKTCDTVEHTMPIPTVSDFLPPACIAGTGEGDSIGLCSYACNYGYCPINLCTCTATGPLIQPPPQTNMSGMAGPGHSNIFDNLCDFACSRGYCPEGTCEYNLDSEISTFRPNLNWGGTGAAICSVSQRPAILQEFRFAMWMAQSARDDLQTWSFYKTFFSENVRADPKFAKNAAGVYNNVVSMLDGSGFGLQITCNFTANPCTGPTPDIAFMNAGRKTMNICPGFFTNTRMTATADKFQNPPASIIDAHHTRSAVLLHEMTHSKFAMKTVHPSQAKDFAYGWESCKLLAEGTFNRGCQPYAGLKGNLCADTSDPSKDGICNADFSQINADTWAVVAAGIFFSNNVGTEVPLVPPSPTSAQAISELSTATTSECVQYNPLMFDHGSAFEISGVVSFGDSFAAGMGTGVTSSDKCRVGQSNYGDLIYQELQDTSISIEKKVCSGDTTTGLGRQIQEWSSQYSANLATLTMGGNDLGFSDIVWNCIVTPATWHFGSTYRQWCVEAEDKARALMNDQGETGLRHKLKTLYKQILEKGEEVDLSLFVTGYPEFFNQDTTDCDQSTFHYFWSGYNPPSDWWLNRMVYLTNDLRAELNLLVSQLNDVIMAAIRDANTEAGSTRVYYVDVQSKFYSHRWCEQGIHEPDSSAPNTYFFLSGWNDLPLDGDTVTSSDASDVSYLKQNGIDLPDPSNCETALGSDPDPWQKWLCLVSIAINQEPDGPIAWSYGNATQAIKDGDLNAQDVSDWYFTYQIKAFHPRSPGMGLYRDAILEKIDATIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFA1</accession>
    <name>A0A1Q5UFA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000298">
        <property type="protein sequence ID" value="OKP11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFA1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="62036" checksum="020DB4984C410158" modified="2017-04-12" version="1">MASGSQPALPLTPPARSARTSAEFNEFPGLHPPEKPNTSLLRPRESRPSDKSSPSSPIIVSPSGDVILKYTKPSSGDSYYWKVDSRMLKENSPYFRVLLDPTKRFVEGQFFAQQLSESSGSGFLPIVVVPATPFTELYGVDALELFLQILCLESLASDENDDEDEGLETVFSFNLKAQPLSLIARLVDIADYYNSPYPVLDALHLLDYSLGKGKSRLQKFSESTLKMSEDRIRQTIVVANFLNQEYIAKVMTHALVIAGSRRWVHSPQVPEGPYLRWQHLSNGLEGMAQPHRTMNVVYGKKDTMTDHYSLEELYYRRQCVLNTITDLQAYFLRKYGALESDEPMPTTSKAVPHHTTHQHRVFQCRAGLGNASQCDLFHLGQMTRFFALRAKSIFIGSTLIDPEFSPPGAEHGDDNEEQPSPGLHISSLIVSLKKHPDYQIDLNHQACGVKRRLLPILDGIEKFVMDARGMLGVVPSIWDQPENRQRLQWKSDTLFAEEVCIILNQITYLQFGPKGAAATAKGGSYSSRSLSQEDYARALFTAKKRKWEPDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG03</accession>
    <name>A0A1Q5UG03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG03"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG03"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="572" mass="62550" checksum="F1D33EA3193B3E8F" modified="2017-04-12" version="1">MGSEMEAAPVLSTPDDRILEATEPVIVNEAKQPLSDDELSITYDIERTLKEIRQARYKRIALQFPDDMLPDAPRVFQLLSRGLNSEDVAGANGTHATGQTKDGAADAEGGITQSVSRLSMADETEKWSPRLYILADTSYGTCCVDEVAAEHVDADVVVHYGRSCLSPSARLPVIYVFTHKALPLEPVVQAFKTTYPDLTTKVIIAADVTYSGHVPELYARLVQDGYSNLFATEVAHEPSSPIPNRTVPETVREAQETLSDWQLFHISDPPTTLLLILASRVAAIHIYPTSNPSNTNIKPLPASTSAALRRRYAILTSLNTVPIWGILINTLSVKNYLHIVDHVKEQIAAAGKKSYMFVVGKLNAAKVANFSEIGGWVVIGCWESSLVDSRDFWKPVITPFELELALKSDAERVWTGSWHSDFQAVLDKPAEEEKEDEDTTSNGAADNDEDDVSEPESAPPEFDLRTGRYVSHSRPMRDPAPRASSQIDGSTAGGPAAARALARRAKGDLAMIGNAVSPGAEFLQSQRTWKGLGSDFDIRYDEEEDPSDSTLVKEGRKGIARGYTVGESSEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGR4</accession>
    <name>A0A1Q5UGR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGR4"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15470" checksum="BFDFD4CC99A6AF4A" modified="2017-04-12" version="1">MLLETGQVEVDTKDISGWTPLHWASLVGNTAVVNALLETGQVDINAQDHGGKTPLHCAAERGHHEVIALFLETEQLDVDAGSDKGWSPIRTALQKGNSKVVRLLLETGDIDLGRDQSRRIKKMLKKLNLSSRSEAESYPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIA5</accession>
    <name>A0A1Q5UIA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucanase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_2329</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 6 (cellulase B) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIA5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIA5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 12" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011818299" description="Glucanase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP12169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="721" mass="77265" checksum="3F3B800FFD65412F" modified="2017-04-12" version="1">MQRTSGWALLVLAHIATAQQTLWGQCGGSGYMGSTVCTASATCSTQNPYYAQCIPATAGGASTTSTTSTSKTTMVTTTATVTTKTSTGVTTTAPTTTAPTVTNSGNPFSGYQLYANPYYSSEVISLAVPSLSSSLAAKASAVAKVPSFVWLDTAAKVPTMGTYLADIEAKNKAGASPPIAGIFVVYDLPDRDCAALASNGEYSIANNGVANYKAYIDSIRAQLLKYSDVHTILVIEPDSLANLVTNMNVAKCANAHDAYLECTNYALVQLNLPNVSMYLDAGHAGWLGWSANLGPAATLFANVYKNASSPAAVRGLATNVANYNAWSISTCPSYTQGDSNCDEKRYVNAIAPLLSAAGFNAHFITDTSRNGVQPTKQQAWGDWCNVIGTGFGVRATTNTGDALEDAFVWVKPGGECDGTSDTSSARYDAHCGYSDALQPAPEAGTWFQVSLAHARRPSNNLKGQVVSYMRLSKLRYGFISTFEPTVFIKRDQNYAFHLSMPTSKDASTTSPRECFAGFAFIAAHNPNNEEKVGIDLRLPPSAYRSRVGDSTKSLINIRGLTEDTIIFGDNGVATGFVTCTTRLSTSTLRRQGNAVYEVQSGHFRYVAKCWSRNHEMRYAASVIRGFWDTDRRFAKNSLQYTNGSTSFERTNPGFSFGFGEQLFVLWKSLPDICREIPHLQRVLKGDPNPTIPLYSPSGSWQAQRDVRSGDAGGDFGGLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIB0</accession>
    <name>A0A1Q5UIB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000240">
        <property type="protein sequence ID" value="OKP12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIB0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="24547" checksum="3D7108F01575751C" modified="2017-04-12" version="1">MDRPPAEELSPGPQPENDVIDEVEVLSDEHLNGTVMRSPGNAPETLAHGPRTNGNSAPIDKVPPKYGIEEGDNGDITDPPVDSLLDCHPCYFHVRMYGEADYFMIDDLKSKAEVHFCASFMSSPERESFAETIEELYSTRANYHELRQVAIEMIVGNLPNLRNGHTSIITSELMKSIPDFTYDLFQATLDKYVREPSEIERNDSQVKFDYWSPSNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIJ2</accession>
    <name>A0A1Q5UIJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIJ2"/>
    <dbReference type="SMR" id="A0A1Q5UIJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIJ2"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005592">
        <property type="entry name" value="Mono/diacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03893">
        <property type="entry name" value="Lipase3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010210390" evidence="3">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mono-/di-acylglycerol lipase N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="294" mass="30768" checksum="5D7E4859D775A2D8" modified="2017-04-12" version="1">MVFSRQFGMLVAMAALVVAAPARPVPRDVSSATLSELTLFSQYAAASYCTNNVNSAGDAVSCSGGYCPQVQSAGAKTLYEFDDSTDFGDVAGFFAVDNTNKRLVLSFRGSRTISNWIANLDFGQTDASSLCSGCEAHSGFFKAWEAVADALTAQIASATATYPSYKLVLTGHSFGGAVAALGGTALRNAGYTLDLYTYGQPRVGNTALAQYMTSQGSLWRVTHSDDIVPKLPPASWGFTHASPEYWITIGDDVTVTTSDVTKVTGVGSSGGNAGTSGDSVSAHNWYIVDIDGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIW2</accession>
    <name>A0A1Q5UIW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000214">
        <property type="protein sequence ID" value="OKP12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIW2"/>
    <dbReference type="OrthoDB" id="4833301at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="43360" checksum="3AA6954BC68C284B" modified="2017-04-12" version="1">MSSARPSGRNADLHDRINQLDSRVLELQSTVLTKDGYVDRRNREDDHIRREMETQRATSHRLDFNVVALRSDVAQINSRLDSVDSRLDSVDSRLDSVDSRLDSMASHMRLSDRVRFNSLAHTISAPISSVPVITATGALKWPGYFPRTVWKFWCLKNRSRVHRLVELAEFYQLGGYKDWSRMQQTDMFANSDSSDSSDESSVITREEAVRRFPETAHRVLAATLGLVYYKIRNEVGEDPDAIPSRPLKRQQEKNASASPGSKSKQVKMPRKLSVSDTYLQRLINGPSVAESRSSGSEEFDELGWNPFSDVSEDAMSKLRSIDPQDIGAVLRALEQGRLKLKPSDSEKAGMSPAESKESKVSHGRLAKSLEKSDVPTEPKTPTQPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ97</accession>
    <name>A0A1Q5UJ97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_1899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ97"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="531"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="614"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="709" mass="79460" checksum="8E925052A9E1F078" modified="2017-04-12" version="1">MNIARGILEAQEVTYKHLNKLLRPIPLNTPTEIELTPIKKIRVTLIDANHCPGSVMFLIEGDNKTILYTGDIRAEKWWVDSLIRNPFLIPYTLGGKRLDNLYLDTTYLYHAGVPPETFCSKAEGIAELLKRVQSFPPDTVFHLGAWTFGYEEVWLTLAAALRTKVHPDAYQLALYQSLGQANRGVDESAAYNGFRLGNDIVPGCLTNDICGARIHLCAPPCIIACQPKTVYLRPFLGRGNDGFEMCDMGAGGGSGDVYQRHELDFIAGMNALHLVKYCLKRMNSHSQQQKLTFEWRMLRDLQNNGGKLSISKYGILLDSDMRFDHFADLLVANVLKYDQNMAVENRANVTGNPRRTVIRFPYARHSSYSELCHFISVFKPKDIHACVVDNRDVSGGRELVDEFFDHLLTDQPGYSRRLQQQKKQVQEAEQAWAAEVEVREERQEAGYPEPAFLEERNEDPASYESLSGMSYELLRELNEKWLLFADVEHDFSSIAAEQETRMTSKLLGLVDLPTPGAVKEKRDEIRRAQEYLQDQTDPAEMQVGPLPPTWSGGLDGPADSRNPKPKTAQRTSPKPKHAKTEATKEVKDSPPARAPRGHWTRVMVHRNEAGVAQIQAASSSNVQSPPAQQSQISVPESDLAPSVGSASSTSLTRERLEELNNMHRLDGSASVQLEARIEAYLAAFEDKFSAWTGMLTSAGDNHGEEEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJB2</accession>
    <name>A0A1Q5UJB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000190">
        <property type="protein sequence ID" value="OKP12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJB2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13815" checksum="1DDD957283BF7ABE" modified="2017-04-12" version="1">MANRVTKNPPLRPGHYAAKLAKALEDEAKAKNRSRHNDAARPLEQVKQGPFTTSSERVKRMEGGREWERKAARRLLKRELAAEIKILKSEMEDLKQVVISLQPLLSEQSRGKRVAFQDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJS7</accession>
    <name>A0A1Q5UJS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="115" mass="12251" checksum="A53B72570ABB331F" modified="2017-04-12" version="1">MAVGPRDADGDSEMASSVGSPHSDSDGVDTGARTPTHNTQPAAPTSELSPPGSQPQQIPDISSTTDYRPRTEVEPGNLSGKGPELPVAAWKTKRAQDEYQRAMEQVIDKDFNLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKP9</accession>
    <name>A0A1Q5UKP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GYF domain-containing protein mpd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UKP9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="748"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="891"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1533" mass="161839" checksum="A01A4EDC38FDE414" modified="2017-04-12" version="1">MPTPLPSSFASAAAGNTQDPSRRGDASTGGEWYALKEKRCPPQSQAPSHPTEPGWVSRSRMNGATQTFRRPSVATNPSHTRDSSQLASASTPTASGAYVPPHLSSNTMSTVLRNGDARYSKEQLLDLYKAQRDTGSLNKHVEDYFVADWDPHTVSTPMNGAWGKREDHKTSAGPEVCWDHGGQAEPLGLTDMSDGEKELFSASVNSPLKPPPTNAGKENANPGTTGRKSSISYTQGHINNYNTSSPNAARPSARRRETGESVGNPMSPTGTNTRFFRDEANTSTPPPALLRRKTDFREPNAKDEKPKEGGVEAASPFGSLKRSSTNPLNTAIGGPSSPWGSASASHNANFSPMGAFGAFSLGSNTAQTPTTEKKAGFGSLRGESRFKDLLSKEGPEDIPGSAKEKPLGNLERLTEEDSDKRAQSPWGDAVKTRASRSETNPFDEPRSGSAALGGSQDVEAPSQADLGFGAFGMTSSIPGFRELMQSQENSRNPTPSLLQGHEPTSPTNTNPYQSPHGDRTVADAEDVDTDGSDIQHPQHPGLTGLRDPSNPFGSMRRVGSGMDLPTIDRSQNSSVNANRNFPGLGGLGGLSGLGGPSGLGGPSGWPSSDAIGTPTRERSAFVGGFGDPIFGSMGGLQSPSLSTLGGGGLFSPHAGLSGTASIGRSSKLGALFSGMAEEQARSESVGLEQGDAQQGGQASKPGSNSASQTPVSAVGSIPANLTHDPTQAPTPGGSISAAQQRTMVMPDRMRWIYRDPQGNIQGPWTGLEMHDWFKAGFFSPDLQIKKLEDGEFEPLAQLVRRIGNSREPFLVPQIGIPHGPEPAPGQWQNPNQGSAQPPFPGSFPSFGTTLTAEQQNALERRKQEEQYLMARQKEHLAQQQAIMKQMQVPGAPPTLQPQLQHQSSAHSLHSQPSFGSITSPAAYQPSPIQAPIQGQQQSPGMPGFFDAAASLRPGGLPNVLPGMLGTELGSQDQLPALLDRLNVGRQDPFAFGAAGSFSARQPDSFLHSQQVASMLQDRAQLQQEQDDFDKANANDPFDQEAREERLRQFHAMRAQEGELGMRTADGLPTHPAAALEHDVESLATDGAEELEVAASEPALTLSQQIHKAASAQRQQQQHEQEQEQEQQNQSVPESAWAKIDHAMPQPFPPPPSASPLPAPAAQRNRQNVAESLAAGSRSQTQTPVDAAPTSLAPWAKDTHEVPKGPSLKEIQEAEARTAAQREEIAAAARRAQLLAEQERLSMAQAQVVPGLPSSANWASAGSPATPSTAGSPWNTKSQPVQTNTATKKTLAQIQKEEEARKQRLASAAAAAAQTATPSPPASAAKRYADLASKAPAPVASATIAATASGAWTTVGAGGKAKAPPAAPLGPRSASGTVPIAPAAAKPRPVVATRTTVGSVPQSNSNQAVEEFTKWAKLALGKGLNSNINVDDFVQQLLFLPAEAEIISDSVYANSQTLDGRRFADEFIRRRKLADKGVVDPVSPSAFAEQKNGGGWSEVAKKGSAASTAASQQREEEASNAAFKVVAPRKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKZ6</accession>
    <name>A0A1Q5UKZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_1240</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="16"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKZ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKZ6"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="20">
        <location>
            <begin position="530"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="889" mass="101222" checksum="D9030DBD9550391F" modified="2017-04-12" version="1">MPGESRSRDRHGGRERERDRARERERERRRERDREREYIRGHYDEDNEGAASSPGQARGKYRFRGEEGYESYDNGERGGSDYDERRRRERRERRRQREREEERGYSDANAVEGRRRERERSKAKESPATSPIKKRDRERDRDGYRRRRDIEDQGSPAKDVRERRHKTRGEESEKERERSRDVVESEARRQRRKAREREERRDREWEREAAAAAAVASKHRSTESTSSASHLLSADAMARLASEHEDGDRRERSRDEDEARRERRRQRKKAALAGAGVAAAGALAADVAEGRSRHKSGARVVSGAYLEEGRSPEMKMRRRGGGGPAMEDDWKHEDSWEGSHDSGDQQPKWKFWASWSKKKRLVVGGIVGVLLLLAIIIPVAVLEANKNSGSDSSSSSSSSGSSNSNLDGISRDSIPSYAQGTVLDPFTWYETEGFNVTFTNETVGGLYIMGLNSTWDDSARANANVPPLNQKFPYGSQPIRGVNLGGWLSIEPFITPSLFAGYSSSVIDEWTLTTQLGSAAATTIEKHYATFLSESDFAEIKDAGIDHVRIPYSYWAVTTYDGDPYVAKISWRYLLRAIEYCRKYGIRVKLDLHGLPGSQNGWNHSGHQGKVDWIEGTNGALNRKRSLEVHDQLSQFFAQDRYKNIVTIYGLANEPLMLSLPVEKVLNWTQEAAELVRKNGVEAAIVLHDGFLNLDKWDNMFKDHPDNMYLDTHQYTTFNTGEIVLNHTAKIQIICNSWYSMIKNINSTSTGWGPTICGEWSQADTDCAQYLNNVGRGTRWEGSYDTSSSTAYCPTADAGTCSCNNANADVADYSDEYKKWLQTYAEAQMSAFETAQGWFYWTWRTESAAQWSYRTAWKNGFMPKKAYSPSFKCGDTVPDFGTLGLPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULH2</accession>
    <name>A0A1Q5ULH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6717" checksum="E305B8B877DBEBE3" modified="2017-04-12" version="1">MQLISLRFWLYSNRWETFRSTTAGADDRPLCLYDASYQSNGISLRGSPLDMRATGKLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM62</accession>
    <name>A0A1Q5UM62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CENP-B-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM62"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="75"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="718" mass="80411" checksum="BD8CFE3DDBD72D02" modified="2017-04-12" version="1">MSSETPQSSHASRAGIPEGQKQALRAWARSQESRPTHAASVAWFEQTYGRRLPQSSVSVILSSKYEYLDTGPATGAFRQQPPQWPLLEERLFVWLKRARETGELSTGDAICDKAREIWPRITEYTNRNPPAFSHGWLAKFRKRFEAYQARGQQDGVVPAPPKNQRKELQALRTLSGEFNEENVYNVDETGLLWRKAPFDTLPCAPSELKKDRAHVCLILCTNATGSDRIPLWVVGHKEMPEALRGVNLKAMNCEWRHNRQAWVDVQIMSEWLTMFYEHVGSRRVVLLLDNKLAHQAAVETTPPPGNVHVQLFPENTTNKHQPLRLGITQQLKHHYRKQWLGYMATTYESGQNPVEMISLYHTLCWITRNWRHDIVNATIYKAFRKTHLVEPQADYLTAPKPPDMTELYEKVIRYNQSGISTKSLEAWLNSSEEEFVGTMDETLRRNLHLDTSILDESVNPLPPYELIPAAADAITGLQTAIRYMLNQSTTTANDILYLETMEKILDRKVRNEFLQQQNQIPTQAAPQPLTQTTAAIPAPSSAPMSAQSSTHPFAQQSSASPARPFAQSHSQPHRPPVRPATQAPLPPGQQPSLFTTSTTQPPSLFSQYTAQPSMQTPTQHLGRPSFFPHQYPNQVSTQSSTPVTNHSPVPSLFPASRSPRAGIRPAGVAPIHVQSGSSSAASTPAPGTGPSMFQARAPSEEGSYHPSEDELSDDAMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM79</accession>
    <name>A0A1Q5UM79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="110" mass="12716" checksum="9849637C8A9C05A4" modified="2017-04-12" version="1">MTLVGLLKRQALVIQAAQNEGNLGKSMIPEDSILSSIRTALNRWRDYWVALRNQVSNDEWASMGFYKNGYNFWLVSQLLITKKDAVDVIMQMEVHCEDKLEKLKVLLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMB1</accession>
    <name>A0A1Q5UMB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMB1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="20558" checksum="EB332150346706B5" modified="2017-04-12" version="1">MDMSSMSDSSSSSSSSSTMSMTMVFTNAHNTPLYSSAWTPSSSGTFAATCIFLIVLAIIDRCLIAFKASMERHWLAAHLNRRYVAIAGKTSEAGRIDADPDAKLASLITAQGVEENVKVVRNISHGPIPWRFSVDVPRALLFLCIAGVSYLLMLAVMTYNIGYFCSVLAGAFLGELAVGRYIHWNEHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMP6</accession>
    <name>A0A1Q5UMP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMP6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="76" mass="8415" checksum="4A0D205E16952FCA" modified="2017-04-12" version="1">MSALKKNEGFKKRQSAVIEKPNSNPSPTLYLPFRPLPHLSQATRGETDATLTTTRAATDLVNQLCLQSSPFEAREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN40</accession>
    <name>A0A1Q5UN40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN40"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="472" mass="52292" checksum="59E596476302EA2D" modified="2017-04-12" version="1">MAMQYFNQIKNRRRSSLIPNPPKPVLTPEDEAFLQKVTSDPEHRSDSAAQNEAQDLGGLAESSQKPVVDDSALDVPLPSSPVEEFGKELGEEERKAREQPEDNRTKSEPAKPEDTPVPEKKKRWSSMFSKKAADAKKNKHSASADKSQTETPTPPSMTAAATDNGDEARKDQEDMTDILERLNLAADNNRVFSVSDETQELLRKFKLIFKDLINGVPTAYHDLEMLLTNGNRQLQDTYTKLPGFMQKLIQKLPEKWTESLAPEMLAVASERAGRSGINMENVGKAAAVAEKAGLSVPSLKELVSKPAAIVGMLRSIMQFLRARFPAVLGMNVLWSLALFILLFVLWYCHKRGREVRLENERLVTEEEIRKMNEDSSEGQGQGQIRPTETLTTTAPQGASAEEVREGVKRVEEARASAVDVAAASDPELEAQRVNEEAPRPAAVPTRSKSRLAIWTRSKPEPTPSNISPYPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPW9</accession>
    <name>A0A1Q5UPW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPW9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="11943" checksum="BFD1389A71EE3A3A" modified="2017-04-12" version="1">MAFDTNVDYDETRAAEINAVGWVFTGIAIAAVFLKIFTRVESKRAGWDDFFIFFSMALSIIATAFVSYSVTLGLGRHAAAVVAQHGMERYEQTAYWQIIAYPFNIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ93</accession>
    <name>A0A1Q5UQ93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ93"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ93"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="27467" checksum="921402C2FB6562FD" modified="2017-04-12" version="1">MVAFDKCETRPAHIDAILNGLDRYNPETTTVFQDYVAQQCEDRSFDLYANLALLKLYQFNPNLLQADTVTNVLVKALTVFPSPAFSLCLALLPAHTQPFPTTSEAQAASQTSDFVESVQKLSRLSTLLESAQYTQFWSTLNSDDLYADLTADIAGFEELIRIRIAVEVGKAFRTITAESLEQWLDLRSRDALAKFVADVCSWKVEGDVVRVPTNKENEARSEVKSERVGVDMFGRVIRRGFEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQD4</accession>
    <name>A0A1Q5UQD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-binding protein REB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQD4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="300"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="457"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="584" mass="66711" checksum="1107A3ECA4B243FB" modified="2017-04-12" version="1">MEVAESPVVGFLHPPSTAESMKPKKKNKSHKDQKSDEPLEAAHTNGTMSSPPPEDDESRPSKRKRDSESGHKKNNKKKRREAEDDAHGELDPHEQSHMFDQEENGEDTADVNMEVDNTPSKDTREPGHTASGVAPLHEGSQDPGTPSEARLKRTRGSRIGAKSHLKVGFFVEEEVKALEEFKIQFCNTHGIAGRTFDAMVQHSERGGEEWPVQTHICNKGEFWNDVYSLIPDRDRRSVYRFMRRHFQDTTQKAHDWTLEQDEELIKLHAQHGPKYALIAKLLGRSDDDVTQRWKNRLQHRATKKTGAWSEDELRAFMRSLEEYRNLLITSSAEPQKAGKDIWDMDLKSISWGSISNGMDNSRTRQQCADKWRKIQKNVAHVRQTLDPDAVFDPADAVKRYHRWNRGPAGEKSKTYVEDDDDDEADESDESRIPSTTPAIIPKLEFAAEQQMDLARVAKEGSVDSSPAQNRNGVDNEDSDDGEDEMPSSPLSDHSRSEVKKLRDEKKERRRRRKEKKERRRQEAAAVDESAEEVEDPSTPKEKRHKDKKHRKSEASGSDMHDVEPVESSKKKSKKDKKNKKAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQU4</accession>
    <name>A0A1Q5UQU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5893</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQU4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="468" mass="50638" checksum="8D39082C41BABB50" modified="2017-04-12" version="1">MGSGIIATTLGHDSFKYYMLGPTGINAPLTGAIVSLYNVGQAIGTFAAGYSANKFSRRWTICGSAIIAIIGAVLQTASINAGMMIAGRFFAGAGCGILLTVVPIYIAEASPPQNRGMIVGLQGMMIAIGFFAANWIGYGGAYAKGNAQWRIPLAMQIPGPLLLVIGCCFIPYSPRWLVQQERHEEARAVLVALHGKDNETLVDQELFQIREQIQLEALAGTSFYSALRQLLSRRHIRRTTLACFILVMSQFSGSSVIQNYQSIFYKAVGFTGKTSLLISGVYGIMGVIGQVIYLFIAADRWPRVRTLWVGSIFLSAMVAICMALSAIYGSGTTNVNGARGAIAMIFIYSAGYAVFFNAMVWVIPSELFPFILRSAGMGLCVFTKSVAAIILSQITPVALENVGWRYYALFIATNFAAALVYYFFLPETGGKSLEEIAELFGDTLATARLDQMEGDEKAVQPVHVERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR09</accession>
    <name>A0A1Q5UR09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR09"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26788" checksum="66F201B4A9CDF673" modified="2017-04-12" version="1">MVNVFQRLARRATTSSGSTVPDPGIDGNNISSRSHDLHRTTSRNSWKRNRRSIVEEPSPRHLILISDNATFDPHIIQRFQAEGFDVTYLGFVCTDDAEKDRKSLEFAVHEKEDELEAGERYAIVGSTPDDLRTFFTDVFIPAGPPSQHIRLLSRTVGADRIVDEILFTFCHSKEVPWLLPRVPPTNRDIQVVVVVVASFFADRIVHQSLYWDQADVLVQAGLLDSDFVPKMTTEIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URL4</accession>
    <name>A0A1Q5URL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5URL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Penicillium subrubescens</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
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        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNK8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNK8"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO89588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="87" mass="9973" checksum="E7D4DC8E04C01E60" modified="2017-04-12" version="1">MAGRKTLLAPIHFIFSLLQKRSTVSIWLYEQLAFRIEGKIRGFDEFMNLVVDDAVEVRLATKTEEEKRRPLGQILLKGDNVSLIQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQW6</accession>
    <name>A0A1Q5SQW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proline utilization trans-activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13503</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQW6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQW6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012434426" evidence="5">
        <location>
            <begin position="27"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="619" mass="68913" checksum="C4B5C930333D67A7" modified="2017-04-12" version="1">MVTNFWADIHHPQLLIFLLILSSPYSTIPPSPRKWSAAKASSNGRKSGKTDKTAPTGDLQSHAIDVAPERHVVPGAHHSPVRLVSIEYRQLQSQSRAQSRTQSQQFQPPSQSSQSQFRAVRGSSIAESDWHTSPSAPSSVPSTAAWYSEGEVPLERDDWWYKGTGNLLLNRSGEHHSVGPAATVHLAGRLNPGSTNLAWDVRPLYDDPTSLRRPIARSLPQLPTLEFAKRLFWVQYAYIGTIFSLIHPKQFEERLDIVYRQPHDFSHRETCLIYCQALLVMAFGLMYSVNQWSGDEGPPGFKYFKFALRFLPDIHEEGSIFFVEVLVLSVKSGNPITIQDEDIGITWPAALSITNDLASWLRSIPDGLRIDFSTLDTHVNRETVSINLHFYSCVNMTARPLVFYIIQRRLDAAASGAPAGDWKDGLAPNTVAVIDSCITAARATTMIMDAAAKHNLIATYGYLDGDYIFSAALLLVMVNAAFPYNEANMRSMEAALSLLRSMADRGNTYLGSRHALLLELRAAIDPKPTAPNDVEQPSPRVDIPDTPKSNQPESPGMEAPMPHPPPVMIDDWLHPIGFPSLEDISFQIDLDDDPALWEGALDQIDIDMDTDWIENTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SR05</accession>
    <name>A0A1Q5SR05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SR05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SR05"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO90393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="197" mass="20862" checksum="9F4718F03E7C7CB0" modified="2017-04-12" version="1">MTSLNIAAEFEFPNVLASLLENGGDPNEPGGHGATPLARSVRKSKSKRAVELLLDANADAHGWEEPWYNERDESGSEVEVKPFAVSLSLSASCASSAVSAVNTLLRNDSDSDSGTGLSGFREDEVSEVGSEAVDNPLIPSNDYSSSFNSDYHQPASSKSTGPSLRESYKKVATPLHLAVKGGLVKNIKLLLEHGSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRL5</accession>
    <name>A0A1Q5SRL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRL5"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="62"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="49938" checksum="35DF1812A9216C37" modified="2017-04-12" version="1">MSPQVDGPAEAAAVDLENARQRSLDVAPVEFEPENKMNNTPEYKQDAFGNEEFAEVKYKIMKWWQCGLLMVAETVSLGVLSLPAAVATLGLVPSIILIIVLGLLATWTGYMIGQMKLKYPYIMTMADAGEVLGGPFGREFMGVCQILFLIFIMASHLLTFTVAMNTITSHGTCSLVFGIVGTIISFLCCLPRTLEKMSWLSLVSFVSIIVAVFICMIAVGIENPGSGVVAVAKTDLYHGFSAVCNIVFAFSGHAAYFGLMAELKNPRDFTKSLCLLQGIDISLYMVASLVIYRYAGDGVTSPALGSASPLIAKICYGIALPTIIIAGVINGHVAVKYVYVRLLAGTDRMHKRDWIAVSLWLGIAAGLWIIAWIISAAIPVFSSLLSLITALFASWFSYCLGGVFWLYINKGRLTSSPRMIVFTIINLVLIGIGLTICGMGLWVSGKAIHDNPSSASFSCANNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRS0</accession>
    <name>A0A1Q5SRS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRS0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRS0"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="566"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="746"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1218"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1249" mass="141254" checksum="0278320BED455EC5" modified="2017-04-12" version="1">MPGVVEVPAVPAAPLFRRDFSVGQQKVELEIDFVNKSLKGSTEITLYPSRVDLRTIHLNFRQGEIKRLTVNGKATTLKYTDPYENLHLYGTQYHERLTQKIDGLLKTPLDPQLEIPIPKSVHIRELDSRSAEARERIALQGAGEDVDGPSDSKAPQSDLPQFSAIVVHIEFVIDRVRDGLQFVGVDSGDRRYPHAFTTNSPESSVGCPLFPCVDDPSSRCAWEISISCPASLGDVFERKITSSSSRSKVQNRYISADDGALDMSVVCSGELTDDITDPKDSTRKTVSFACYTPLSAQQIGFAVGPFEYVNLADFRESDQDEQLGQNAIPVHAFCLPGRADEVQNTGFPMAQAIDFFSLSYGSYPFSSYKMCFVDDVATDTLPTAGMTICSSHLLFPADIIDPMYDSTRALVHALACQWSGINIIPNEPADTWVTVGVAWFVTDTFMKKLCGTNEYRYRLKQTSDRICDLDYERPSIYDMGNFLKIDPSEYRFIALKAPLVLFILDRRLTKASGKATMSRIISRLFLNSRMGDIPNGAVTSPMFQRLCERFGHAKLDVFFQQWVYGAGCPRFQATQRFNKKKLVVEMMIRQVQSEQTAARDLEKDAFLRDVKEEIRHVYAGPIQPVFTGSMTIRIHEADGTPYEHIVEIKEGVTKFDIPYNTKYKRLKRNKKQRERAVASGDAETQEDVLLYCLGDVLQTEEETQAWRLADWTKEDEERMGQESYEWIRMDADFEWICRLSLGMPGYMYLSQLQQDRDVVAQLESLQYMAAQREHPLISTIFTRTLMDSRYFHGIRVTAAKALIKHAKDEVEWIGLHHLETAFQELFCLPGSPMTRSNDFSDRAAYILQQVIPDAISQVRDNSGKTPLRVKRFLFDKLKFNDNSNNEYSDNFYVASLMRSLCHAMLGRTEPRPEDELSHFDMERVIEAQAEEQLEKDAIAEFDRYRRMDEWSSSFQNLYARAALQCQVQLMQANVLEVDLMRFVPYTRSGTYDLLRIQAFECLVDLDIAQNNDLFRWLIFTMTSDSSAYVRHHCQRLFGRALAKVAFGRPAQAEPAQTGGLIIEQESTTEVRQADLARRQTVPGAIEALKREMSTEASLRDCMWAACNSTAIGVHELSELTDVCSILFDPVTSKIARLKYPRFWKVQHMGHGQLRFYRSTQVRTSLGPSKDSAKRKREEQSMQPPAPRITFKQSKTSATPSTPSTPSAFPKISVPASVPHAATSTPISATPSTPASGGGLKLKLKFGQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSH1</accession>
    <name>A0A1Q5SSH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSH1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSH1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO90938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="109" mass="11907" checksum="B0FE4835B9190315" modified="2017-04-12" version="1">MKAALADEDGVLLENFMRESVEPAVSGSTVAVCLINLTTGELVVSNLGDSHVILAERDPKTEYPYHIRRLTQAHKPEVPSEEARIREAGGTVEKRNGITRLGELQLNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUB5</accession>
    <name>A0A1Q5SUB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial metalloendopeptidase OMA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUB5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO91608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="24210" checksum="5C4CEC8FD5AD58AA" modified="2017-04-12" version="1">MTGRRRFNCVSHAAELKMGEQSYREVLAQSKGRVLPDNHPLAQMVNRVLQRLIPQVDIVGADWRVHVIVDDGNANAFVLPGGKVFVYTGILPICQDEDGLAAVLGHEIAHVVARHPAERMSNSFLTLGTVFLISLLFDVSGNLSSMLVNLMWSLPNSRTQEAEADNIGLMMMAKACFNPEAAVRLWRRMQEQEKAAPPQFMSTHPSSYNREEAIRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWC5</accession>
    <name>A0A1Q5SWC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="12075" checksum="71C6148FF7B5A4C0" modified="2017-04-12" version="1">MVNRRVASEEHAASVIICLFNLALASLVSLARGTGQTCRTATKWQMHPRHLIDILVLYVGTQWMMTSVDDGNFDPTLQKKSRDMASRIYHAYNEKYTILPPQLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ35</accession>
    <name>A0A1Q5SZ35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ35"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="388"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="650" mass="72389" checksum="47BA8A035F027ABA" modified="2017-04-12" version="1">MGLKSPIPLQELKFNVPVPYKLHVDRDLLGLTKQKLALARYPEEQTDFAESNWAQGAKVSRVKELADFWRDEYRWEDEEERLNAVFNHFIVKVDVPGYGSLVLHYVHHRSTNTNAMPLLFSHGWPGSFVEAARIVHPLTQPESASDPSFHFVAPSIPGFGFSPAPTKSGVGPEVVARAYKILMADVLHYPRFVTQGGDFGSFITRSIAIQFPQLVRGQHLNMFPVPPPTFTSAPLAYLRWCFAAVTYSDFERRALAVRENFEKDQSGYLEQQKTRPQTLGFALGDSPVGLLAWFVEKFHDWGEVYEEFSDTDIITLVMMHWIQGATPGLRFYREAFGSSKREAEKTFETYLSVPTGVSMYTKEQLHPAPLTNIRMAKNSAVVVRVANGNQPSLSQENIAIPSPEANQVLVKVSHVAQNPTDVQAFDSNAFGDGAVLGCDFVGEVVELGSQVTRFAKGDIVAGLIWGASVGQYAIQLASMYRINVVTTCSPKHFELARSLGAKHVFDYKDQDIIQKIQASEPGILHVFDTIGNPTSSTIASRVFKSGAGHLCTVRPGKANTENVAPGTNVTDVLVWTAFLKDHSYGDFKWPASKDDHELASELFEKLPAWLDDRTLRPNQPQSRKGLNSVPEGFQEHRDGKVSAFKIVYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZF2</accession>
    <name>A0A1Q5SZF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="347" mass="39528" checksum="2C6629599C1EF4C4" modified="2017-04-12" version="1">MSVDRRKRKKDAIRIQRLNEKVAADLVTDQPRPFPQPTAFSTNEGWTEEISLGPGPPTRRGGNRNNARTNSWNTDQSSQLKKDRTSGLMQPLNDRWKSMRYQREDEPLWGQEVRGSSIGFSGRGRTDHQEPPKYYAARVPPVNDLHPPIVSGPRSRAETRWMLQPPPSAKVMAGKERFDMTSPRDSMGGFDWPSRTIRGAAIQEEEPEHISKETEDGTVDTSGMQQQLPRRPSLSRVRTSFESDICDDFDQHRDSRSDSMFSVGDDQSFSTSWKYPDTPATRPASNSTEGSIKAPRPQISKTLSTLKRGDGNKHKVHLLQLEINDDRDEFGVGQLERIRPWRWSMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZJ3</accession>
    <name>A0A1Q5SZJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZJ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27374" checksum="DFACA92EF6195990" modified="2017-04-12" version="1">MQNNANEAQPWFTPNNIVTSADSENFFRDVFPLFSDSDFSKLKEVYPSSGDTNPHMTNYSTLGYTGPTALTMSGWANGEQQRVNNLQAEVLFVCPAYWLAAAFPEAWKYEFSVPPSPHGYDMGAYFYRNGNWPAEFVIAFESIWGNFIVHRDPRISQNLACGTNCDPRTADMTQWKPWNSEQRAQLSANMTGGTPAFYNAAGTLVPSIAEPGLSNSYTLSDGVTWEGGRGNRCKFWQEMGPKIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0H7</accession>
    <name>A0A1Q5T0H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11961</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0H7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0H7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012592441" description="acid phosphatase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO93682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="48976" checksum="D720E646BF577A67" modified="2017-04-12" version="1">MKSVVATLLAAATLAHAQVATVSSPSLADINKAAATTLPESPTSDVKGLAFNRFYQVWLENIDYEDAAADANMQWLATQGILLTNFYAVTHPSEPNYCAAGGGDTFGMDNDAFIQIPSNVSTVADLLDTKSISWGEYQEHSPFPGFQGFNFSNQKTFKNDYVRKHNPLVLFDSVVQNETRARQIKNFTDFEHDLTDKKLPQWAFITPNMTNDAHDTNITFGAKWERSWMSTLLTNDYFMNDSLILLTFDEDDTYNKTNRVFSVLVGGAVPDNLKGTKDDTFYTHYSSIASISANWGLPSLGRWDCGANIFEIVANKTGYVNYDVDITNLRLNETYPGPESAGEISKFSPIWPVPLTDGKCSAGNGILDIVKKTYAGHAATYNYTSPYPWDTKSDYNTKVTITRKTASNTTSTTSSASSTASKGAAAAITIPGSTAVTGALVAMFAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0L6</accession>
    <name>A0A1Q5T0L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0L6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0L6"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="455" mass="49630" checksum="6BC1F4DF0D1017D4" modified="2017-04-12" version="1">MESVTPQPPAYHNDKIGEQKHTPNFEEEGGLKHGEVADAFGNEEYAEIKYKTLKWWQCGLLMICESVSLGVLSLPSAVATLGLVPGVILIIGLGLLATYTGYNIGLMRERYPHIQNLADAGEILLGRFGRELFGAGQFLFCIFVMGSHILTFRVMMNTITEHGTCSIVFSLVGMIISLALSIPRTMRGMTWISFASFLSIFSAVMITMISVGVEEHPGRIIEATVETNLYTAFQAVSNIVFAYCAHVAFFGLIAEMETPKDFKKSLFMLQGFEIVLYLTAAVVIYYYVGTDVESPALISAGPLMKKVAFGIAIPTIVGAGVVNGHIGLKYIYFRLTAKSDLMHQRNWKSVGLWLGLGVSCWIVAWIIAEAIPVFSDLNSLISALFASWFSYGLSGVYWLHLNAGQWFASPRKIALTILNVAIALFGLALCVLGLYASGTAIHDNTSSASFSCSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0S5</accession>
    <name>A0A1Q5T0S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0S5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202775" description="Glycogen debranching enzyme" evidence="1">
        <location>
            <begin position="20"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="753" mass="81706" checksum="97521F5C6599BD34" modified="2017-04-12" version="1">MKDLLKLSLFGSFATAVAASSGDARLHARSSAPKCSNAPSTLSLSDPPYDNYFYSDCNVAAQAVVTSPLPQSNLSLIGPRLIVAWPAGDSGVCAYFAPQNGVNGTLSIEMVNSTAGQPLGPVYTAGSNSSAPPTVGVQGVLRFNASATLTVPILGSIRTIRDFVEGPSLLRSEIQDAIKFVAHNDGSASLQRTWLDNVTSTTLTFAPSNGTNNKVTVSNRTLVLPAGDYLFSASMNYPQLTVLKSAFVLNSASRNLTNTMPGQTAALSFLSYSEKLLAGAWRFLTYFGRDSMLSALLLEPVLSSGNASAMEAVIGAVLERVNRTDGSVCHEETIGDYATWTNLQNNITSNAMVCDYKMIDSDYYLPVLMQKYFLENPVGQKRAAAFFNTSAGLINAENQNLTWGQLSLINAERIMRLARPFAEKQTKENLIHLKDGQVVGEWRDSEYGIGGGRIPYDVNTALVPAALRSIAVLTRQGLYPKHKEWSNLATKYAQIWEDKTLDYFKVTIPKSKAQDLVASYKKESSFPGPDQATSITDDVVFHALALDGDSNLTKVEVMNTDDCFRHFLLNTTDDTQLTPFLNNSATNIRRTFPAGLMTSAGMIVANPAFGGDPVYAQNWTTGAYHGTVVWSWQLAMMAKGLELQLGRCELTSNFSVSRRETDKGTVAPIPAFCGDDSVYGNVKAAYNELWDVIEQNESQLSGEVWSWVYRDGGFQVTPLGVLPAPGGGSQTESDIRQLWSLAFLAVTRNADYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T138</accession>
    <name>A0A1Q5T138_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiotically up-regulated gene 70 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T138"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T138"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="221"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="426"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="615" mass="66932" checksum="575CDB8B750EAD45" modified="2017-04-12" version="1">MSAASSRQRQNQSKRDEAIRRKMEADLNKKRHNPTKARNARKAPPGTVLALKPSQALQIKPTLSIAEAAQLMAAKREDCVLVTDDDERIAGIFTAKDLAFRVVGAGHKAREVTVAEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGILDITKCFYDAMEKLERAYSSSRKLYDALEGVQTELGSSQPQQVIQYVEALRSKMSGPTLETVLDGMPPVTVSVRTTVKDAAALMKEHHTTALLVQDQGSITGIFTSKDIVLRVIAPGLDPATCSVVRVMTPHPDFAPSDMSIQAALRKMHDGHYLNLPVMNEGGEIVGMVDVLKLTYATLEQINTMSTQDDEGPAWNKFWLSMDHESDSMVSGSQPAPHTPHRSVMSPDLARSQYDNSVLPNESASHHGGEEHSEVASQHHQHHHAENVPFPFKFKAPSGRVHRVNVLSSSGVSDLVAQVTAKLGTEIEAVGGEAVVEEGRLSNTGYALSYMDNEGDTVSITTDQDMLDAIDLARRAHRDKVDLFVHDPAQPPIPATLDPQPAKPATPVIEEPKSVVTEVPSEEPLLSKPRQAFPAHHGPEEQFITGVPNELLLPGAIVTLAAVIAGVFILSRPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1D5</accession>
    <name>A0A1Q5T1D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1D5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1D5"/>
    <dbReference type="OrthoDB" id="5427699at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="428" mass="46697" checksum="036F4A73B2EE4D85" modified="2017-04-12" version="1">MKTAVSKLPDGHGCVYKEVRFSPTATPVRRAQSVSTSTPSMNSKYRQTRIPQVPQDPSFGLDTSYIEQSRELLENQRAHLETERALFAQERQLWAKERILLRTKIAELESLLKSQRSQSILATGHPPKPAFGTPQYLDSHDHLSSAQVWEGSSPGSRPTRVFRDEEILVNAHLSPISERSGSNPPSLDAALSPRARAVDASGATISIPVPIEKLDSRLDGITLKSTALPPGVVARVITPPSPSPLETSSPALATAPSDPARPGMEHRNSLKLKLSELGRPNENLVRDAGHTPMAIIEVDDSQRTTKDASPVEIPPFQEEEAPLAPMVTHVHQPSEHAESYFPDLPDDPALTGPLGLTNDEEHDSSFLNELDTRLLDQAKRILSTSTVSDGEEEPDPKAPNQGEPEPEIKFKNSTNFGTAFGISNFGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T251</accession>
    <name>A0A1Q5T251_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General amino acid permease AGP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T251"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T251"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="140"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="510" mass="56383" checksum="C3B7EA8FD7973B72" modified="2017-04-12" version="1">MEPATHPPEMGERKNSREAMKGLDPRMHAKHDSEEALTSELISAGSEHLQRKLGGKEIQLLAVGGAIGTSLFVQMGASLPKGGPAGLFLGFVVYGTVIWCVNQCFAEMVTYLPIASPFIRLGGFWVDDAWGFAMGWNYFFLMAIFKVFLMLGLIAYTFVTMVGGNPEHWAYGFTYWKNPGAFVEYLAPGNTGRFLGFVSCIIQGSFTMVGPEFIAMTAGESENPRKLMHRAFTSFVWRLLLFFLGGALCVGIVIPYNDELLLKYIEGTEGGTGAASPYVISMVKFGIKGLPSLVNALIMTSVISCGNNVVYSSIRTLHGLAVDGKAPAIFAKCNKFGIPVYSVIAALAFCLLSLLQLGNTSATVLNWLVGICTASYMINYFATVVTYLHFYAALKRQGIDRKTLPYRGYFQPYAAYYAAVMTFVVALVLGYTVFIDGHWDITTFFTSYLMIGFFIVAFVVWKLFKRTNYVRPGTADLQLGDIKAQIDLYEALYEPPKRGKISGWFNSWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2F8</accession>
    <name>A0A1Q5T2F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2F8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2F8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="61081" checksum="C275897B21692464" modified="2017-04-12" version="1">MAQESENAILNRKRAFKPKVSTGCLTCKTLAPAPAVESSIEARALELFFHKTATQLAGSFEAAFFQGSVAQLSLVEPTIRHAIAAIAILHEELSSSSPGREWDINGPEVPVQCYNRAIRALLQKFETEQTPISLTSMANILFTCFEYFQGNLTAARSHVKSGIKLLESWRENTRLLAHKPWGQSYDSYESYFMETEIAPLLTVFRINILDNEDIEDARFYLNPVDKNGDVVLGDRFENIQQARAGLLDVITSASGRLRAVNEHLPNNDLAGKKVNQITHVIPEEIMSQWETKFDDLISRQSYLWGNKERQAANIVRIINIAETLRARNYMTSIESSWDSARAEYEEMLSIADSLISDHSRFPNDGFRLLSLDFGMLFCFHLLAWKCRWPSLRRWALSLLCKVPKREWLFDPKHYHAIFSRILEIEEGYLGALPEEIIQQDLVPPENARIYDFTVIPQSSPSSYSSGRAVSYSVTFWSKPMGLDGPLSSLTEYMLLEASQPGETAVPSSFIDKHHPRLRTEDIASIGPRSTSAMACLESNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T3Y2</accession>
    <name>A0A1Q5T3Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11512</name>
        <name evidence="3" type="ORF">PENSUB_4812</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000710">
        <property type="protein sequence ID" value="OKO94928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000446">
        <property type="protein sequence ID" value="OKP09791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T3Y2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T3Y2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="10585" checksum="5DDED81BE876506D" modified="2017-04-12" version="1">MTYLMKEAGKQVWDVVSGDLQRPDCLFKYAKPISADINPLVEPHLNEAVRQRAIDARLEVEVQAFERHHEWKPKPTTYSSGTCPPTSVCTSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T467</accession>
    <name>A0A1Q5T467_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethyl-sulfide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T467"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T467"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="491" mass="54162" checksum="21ED8017DB487AB6" modified="2017-04-12" version="1">MSETTKKQLIINAFAMHSPSHLNPGLFRYPTDQGSSYKNIQTWIKLAQKLEAAKFHAIFFADVLGGYDVYKGPANLDPTIPAAAQFPINDPLYSVPAMAAATESIGFGVTASTTYDAPYALARRFSTVDHLSGGRIGWNIVTSYLDSAARNFGLDTQVEHDERYRIADEYLDVTYKLWEGSWRDDAVTFNGSDADDGSGSRKTAQYADPARVRQINHKGKYFQVPGPHLCEPSPQRTPFLLQAGTSTAGKAFAAKHAEAVFLHAQKPELVRPSVDSIRQQAAELGRNPNDIKVVAGALVIVAETDEAAQARFEEFKKYGDREGALALFGGWTGYDLSTYADDQDFRFVELPAVRSMVNHWASTVPGTEGLKWDKRTIADYLVLGGNGVKIIGSVKTVADELERWVSVGDVDGFNLSYASLPDTFDDIIELLLPELRRRGLFWSDYAVKGGTLRENMYGLSGQSRLPEAHTGAKYFWKKGQDVPPYSVDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T605</accession>
    <name>A0A1Q5T605_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T605"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T605"/>
    <dbReference type="OrthoDB" id="4369384at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="164" mass="18255" checksum="83B92DCE202B3AE2" modified="2017-04-12" version="1">MHPKDRDHIDKAISASREVLERATAMLVEGRLRYAPRRTRVCIISASTLLLKAISLGGSAHDLKVKMGKLDQCIAALRLCGIDDLDFLSRYGELIEQHLQRFRDQFILLPDCGGPDQPGEGSTAVEPTGDDWKVRPFDPRIAPWKSDSKAIPLGISFDSLDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T855</accession>
    <name>A0A1Q5T855_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T855"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9332" checksum="ABE0BB56A701917A" modified="2017-04-12" version="1">MAPIRVPRVDYGVGCFQEAVRSGTIIVPRITSICTRLSVTAITTRLMIEGYELICVGVPMLFYTPATTTAIDVILLHMSAVLGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9H9</accession>
    <name>A0A1Q5T9H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TNF receptor-associated factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10458</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9H9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9H9"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="179"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="50189" checksum="EFC1ADF6FB8D845B" modified="2017-04-12" version="1">MDIRDFLAMEANSDRDYLVDLRALDFVSSYDSHLMCPICHCPFVQPVRLQCDHIFCQKCLGSAITTFRSADSDEFPCPSCRTPTTRISTSVPRLLVNMCDEIQVRCPLVGEGCDEIIPRGHVQSHVEKYCGYRLMPCPDESCGKKTRKKDLQPEERCMHSYCRCERCKEDVMEQDFAEHDRELCPSLEATCDDCGNTIPRRSFKKHVETCPDVVSPCAASQYGCSVKVRRADIATHEQQCPLVSIGPYLEAQNTRLNTLELTMRHLQQRNEIFEDGMANLRSALLESARASGGDRSRGRSATNGDRDRQSHIDTDESADPANSFSSHTTQYLLSLHESLREEVSQMSHALTDLDARASMTIMNECLRIKEDMAHTNAALNSVRMQVQWLMNPRLHNGTRANGMRTNSASNETTRTQLTSTSAAGPSGASLGPLRPRRPSDSGREGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9M1</accession>
    <name>A0A1Q5T9M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_10464</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9M1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9M1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="18">
        <location>
            <begin position="163"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO96910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="339" mass="39402" checksum="E8FBBEB12D608636" modified="2017-04-12" version="1">MATGNKDKITDWVNPNDKSGEFKRQQSVFRSFISRDPGAEFPPEKGRYHLYVSYACPWAHRTLITRKLKGLEDIISFSSVHWHLGEKGWRFVTSDEDLPGENTIPDPLHKDFTHLRDIYFSQNPDYTGRFTVPVLFDKQTGRIVSNESAEIIRMFYYEFDDILPEEYKKIDLYPSALRSEIDTSNEWIYNDVNNGVYKSGFATTQEAYEKAVTTLFSSLDKIEAHLSKQASVSPYFFGNTVTEADIRLFTTIIRFDPVYVQHFKCNIRDIRSGFPAIHRWVRGLYWDLPAFRDTTDFEHIKKHYTKSHKQINQFAITPVGPFPDVLPKDEEVKAAQVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAL4</accession>
    <name>A0A1Q5TAL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012208739" description="Protein ecm33" evidence="2">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49035" checksum="FEBD9C83C7332017" modified="2017-04-12" version="1">MIWQVNQKALLGLILFTTSALAVNCTAVSVKSESDAETLRQNCPIITGNLTIGPFPQNVSSVHIKLDGIEFINGSINHEAGDGGNTFTVSSSTLLKVGGSVIFGGDDDKACNVNNFTAPNLSIVSGSFWIGTRCSDLTYLDITSLEYVDYIHLEGRSLTTLRHTKLSNTTGLWIGDTLIDSVDSLFNNPLNITGEAILGTLPNVRYVTVGFQSAYSLEVFSNTTVILGGSSTTEMSLESLRLSGLTGLERSPKLESLTAEVVTIMPTGNISQIYLPFDDLRMLSVSEAAYSNVVTLRLPAKAVNWTGGFMLDVVLSPGLNLSSMYGVDEQGNNIQTWYWPTNVSYIRISETIVANPFFDTFVAQQNGLTNGTTTPSVLGGFSITPSNRSHFNCTPFYNLWRIHRLTKSVGSYGSEEEYDCLSRGVSESAGHYYQVPSLISIIGVVFGILAWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAN3</accession>
    <name>A0A1Q5TAN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAN3"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="784" mass="88024" checksum="B6E5B828A40DC0AC" modified="2017-04-12" version="1">MAAKTTGISVAELPPVDIPSLQALKAEHEFDPNLPTEIEEELDAALQTGDDEIKAHVVEDLLENSPYPEVRAAVLPYDEGGTGNTIRAWVLGLIFATIGSGLNALFSLHSPTISITSYIAEVVAYPFGVAWARFLPNLTFTLFGNKLELNPGPFSKKEHALITIMANATFAGGFAYTLDIFTAQRGFYGQRYGWPFEIFTTISTQTLGFGLGGVLHRFLVEPAAMIWPSNLVNTTLFTAMHDRGLNPPDPAKTAGWRINRYRLFLYVMTGAFCWYWFPGLIAPFLSVFAFVTWIKPNNVIINQLFGGATGISLIPISFDWSIISGYVYSPMISPWFAIANTLIGMVAWFWILTPALHYSNIFYGKFLPMSDSDSYDNTGSVYNVSRILTQQYTFDQAKYESYSPLFLSTTFALCYGLSFAGLVAVILHVVLFHGKEVWRRMRDSRQKDEDIHSRLMAKYPTVPVWWYVVVLVIMTAIGLATVLSYPTHLSWWAFFVSIIIALVWTLPIGMVQATTNIQLGLNVITEFIVGYIQPGKPMAMMLFKTYGYISMSQALYFCQDMKLGHYMKIPPRVTFWAQMASCVWSSVVQVAVLNWAFGSISDICSSTQANKYTCPNGRVFFNASVIWGVIGPKRMFSIGEMYSGLQWFWLAGLALPIMIWLAVRRWPTSVFKYLNAPLIFSGSGMIPPATPLTYLMWGIVGFIFNKWIRNRWRGWWMEYNYVVSAGFDVGTALCLIVMLFAISLSNSSFPSWWGNDKALSTMDYTDTAIQVVLPAGEVFGPKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAP4</accession>
    <name>A0A1Q5TAP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAP4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14343" checksum="BFBC5BDAE71F29BE" modified="2017-04-12" version="1">MNIFHIAIIRGQQLKKCPINDHAKDNASHKGDWQTRKNSQSTVQSAVQLSSGPKVLSNSRPNEASTSRPNTQPSAGSDEESSSDSDDESSPKPTGQTKSSSNAPSSARPDIEYIWITERPYAEVDSCPCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAS3</accession>
    <name>A0A1Q5TAS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAS3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAS3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="392"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="855" mass="92652" checksum="504EAF095D097A42" modified="2017-04-12" version="1">MVDTHQQNIALGIVVAFPIIGGLAVLLRLWSRHLSRSALTSDDYLITVGYVLAVGQSVTSWYYIKTNYVGIHYWDIPKDYDVKLGLVWNYVNQLLYNPTLTVVKLSILVFLRRLESRSRIVNGLIWGAMIFVILLFVAVLFVDIFQCTPVTYVYDMSIPGGKCIAQGAFYVSTAALNLFTDIVVLAIPIIITWNLQMPLRRKLAVCIILCLGGVATAIGVWRIVILAKGFFSTAVNPDPTWDIGFCSSAVEVNVAVVTACGPSMKAIATRYLPRLLGTSRGEHSGYGAGTSGGSRGRFPGSKLFSTNKSQHKSQLHSNADDGYEMADPNGGHTVDIGHDSSRFDMRKYRRGGDSPSISSGSEDGVAGIIKTTDVSVKYDIGGRTPDDRSRDGKHANPGTDQAWASCPNNSAEDVDVAVQNSHAAFEEFRKVSPRQRAKWLLKWHDLATQARDDLAQIVTHETGKPLAESYGELDYSLGFLWWFAGEAERIQGTVSVPAAANRRLFTIKQPIGVAAALVPWNFPVAMVLRKVGAAMAAGCTMVVKPSPETPISALVLAELAQRAGIPAGVLNVLTTDLENTPPLSEALCKHPLVKKVTFTGSTRVGKLVAGHCAQGLKKLTLELGGNCPFIVFDDANIDQALDQLMALKWRHAGQACITANRIYVQAGIHDRFASLLKERTSALVVGHGASAHTTMGPLTTPRSIDKAISQVEDARKHGAQVILGGKPLTSQKGYFFEPTILSGMTEDMQISHEESFAPIAALYKFESEDEAVKLANATSMGLASYAFTKNIDRMWRLLENLEAGMIGMNTGNQSAAESPFGGIKESGYGKESGKDVAVNEYLVTKTGTLTIEGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAU5</accession>
    <name>A0A1Q5TAU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Annexin A7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAU5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="986" mass="111674" checksum="171A56D5968550D7" modified="2017-04-12" version="1">MSLQVNDPRSRTRSKSPGRSRERSRSRDTRASELELEPPRSRQRSRSPAVEIAPKSSASRDYDLPRSRSPAVEIAPRSSKSKKYDSDEENEIDRQYRLLKEGRLGGNEGPSNVIARVPRSAGRYDVDRGEEEDDEDWRRHRDREDVTRRRREDTRYEHSESDEDLRKVRPRDSRDPRGSKDSLSGRESRDPRGSKESLSQRESRDPRSSKDSLSLRDSREYNGRSHQRRPSSPPGRDSRLTDSDDDSDDGLAYGDTHGSHPSYARPNKYKYAQPTQFHPSQPGPPRQSAHPDPKSSDWADIPECERPGFVPPASHPSSQAGVPSTMPGGFPTASTYADLPATTAPSFPMPQYAGIPGQQQIPYAHASSGPYTPSHYRTASAADASHPIPGQYAQPVQYQYAHVDPNIRYASKATPVQPYTASPDQQFAKPVEQFNKPREPQPVYPYRYSNEPQFVEKQPQAPAPPPPQQQQHHQAPHQVQHQQLQPEYGHGQGLQQPQQLVEITPGGRRGRPHSLSVSSANNLAVAGAHSLHAGHPPASPLLEAYHGTYQSISPMPSPIVMPHRDDDISDLEPLDGTSNSESGRRKKHVRSKSSISEKETRHRSSKEKIKEKEKDSDDRGKDDKRRIRHDRHDSSSTISDRDRDRGNMVVISPTTGRKRVSFYDAGADAADMQSALNHRTIDNKTIIHVLPRLTSDEILLLRAEYKNRVKMHGKGINLAKHLRLKLGNSSFGKVAYATALGRWESEAYWANCYYQAGTSRRELLIESLIGRSNAAIREIKSCFRDTRYNDSLERCMRAELKADKFRTAVLLALEERRQDEREPLDARLIRQDVGDLHRALVSKEGGETAMINIIVLRSDAHLRELLREYEAVYRVNFARAMIAKSRNLVGETLAHILNGAINRPMRDALLLHQAVRESRTGRERSELLISRLVRLHWEPRHLELVKSEYRRRYNERVEEAIAEEVMSSSGSSEWGEFCIELARSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB09</accession>
    <name>A0A1Q5TB09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome non-ATPase regulatory subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB09"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="266"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="56333" checksum="EC7CCE34522EAB94" modified="2017-04-12" version="1">MSAGLLKPEKDFTKDADKLIPEAEALAKTDVQGAIDKLLVLEKQARQASDLATTSRLLIAIVTISKNSGDWSLLNDQVLVLSKKHAQLKQATTRMVQEVMKFLDDTPNLDVKLSVIETLRTVTEGKIFVEVERARVTRILSNIKKTQGDLNAAADILCELQVETFGSMTRREKTEFILEQVALCIERGDWTQASILIRKINKRYFARKPKKSAEEIEKLKKQAEEREKTRGPDEAPMEVDDDVTDLKLRYYDQQITLANHDYKYLDVCKHYREVLDTEAVEKSPAQLRASLARIVYYIVLSPYDNEQSDLLHRIQSDPRLSQVPVEARLVKLFTIPELMRWPMVAEQFGPHLCETDVFDAKDQQSADNQAHRRWQDLRKRVIEHNVRVVAKYYTRIQMPRLTQLLDLTEEETENYISELVTSKTIYAKIDRPARLVNFAKPRDADDVLNEWSSDMKSLLGLLERIDHLITKEEMMARILPSRGEKAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCI6</accession>
    <name>A0A1Q5TCI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCI6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002008">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="523" mass="57537" checksum="FF24C607B295D8E3" modified="2017-04-12" version="1">MARTYSPADTIPVRHLHQSIGKSKKPIVVVRWTPEGRRLLTGGHTGEFMLWNGTAFNFETVMDAHYDQVQAGVTSLAWSHSHEWLISGGQRGDIKYWRPNFNNVETIDDAHHDAVRDLAWAPSDTKFLSASDDTTLKIFDFTSRTCDTVLSGHNWDVKSCDWHPTKGLLVSGSKDHQVKFWDPRTARCLTTLHSHKNTVTSTRFSRVNNNLLATSSRDQTARVFDLRMMRDICILRGHEKPVSSLTWHPIHSNLISTGAEDGSLYHYLLDEPNLPAGHVPTVAPYDSPDPANTPPQVIFPAHRVQYAHGATIWSLDWHPLGHILASGSKDNFTRFWSRARPGETSYMKDRFHIGEEAAEAQGTWSRGFGRRQMREEEEQEMQDEAESLVDQRRPGPPTLPGIQAGGTPQPDGPGFLPGIGGAQPPPPPGLPGMGGMNPDRLAAIMSSQPPPPPQSLPPPNQPIPGFPMLPGMGAAPPMNMDLAQLQKQLASQGYPMPPNMPMPPGFGGLPGLQGGGMPDGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEY8</accession>
    <name>A0A1Q5TEY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEY8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="42951" checksum="748EEB297063CB8A" modified="2017-04-12" version="1">MSMVSNQDSTLNSEDTALYQMNLLARSALDLTLHGLENRSLNHDRGSCTLETLRVRRDWRALTERERRAYIDSILCLQQLPPQTPDALAAGAKTRYDDFLATHINQTWHIHRTGTFLAWHRYFIYTFEEALRNECGYSGDLPYWNWGSDIDSMEQSPLFDGSDTSISGNGAFIPNQPDLRIPLGHTDIPPLILPTGTGGGCVTSGPLTNYTVNMGPSFLYMPGGNVSRMSNPLDYNPRCLKRDLTNSILRSNNNHSTVLNLIQNSPDIWSFETNTQGAPGSGLLGIHGGGHLAMGGDPGRDADANPGDPGFWNHHSMIDRIWWMWQYEDLEEREFAVSGTGTFLNEPVSANTTLDTHVNVGFVKRGSIAMRDLMSTTAGPFCYVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF27</accession>
    <name>A0A1Q5TF27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATPase get3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="27"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO98843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="36093" checksum="52E8AA79BF01D306" modified="2017-04-12" version="1">MSSAVIHSDDLDMEPTLQSILNQNTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRKSVLLISTDPAHNLSDAFGQKFGKEARLVDGYTNLSAMEIDPNGSIQDLLANGDGQGEDPMAGLGMGNMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYETIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGARGGLPGGQNMDELLQKMESLRETISEVNQQFKNPDMTTFVCVCIAEFLSLYETERMIQELTSYGIDTHSIVVNQLLFPKDGSSCEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKDKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFV3</accession>
    <name>A0A1Q5TFV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xanthine phosphoribosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFV3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFV3"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="204" mass="23111" checksum="84782D41E5A29DD8" modified="2017-04-12" version="1">MVQKFYVTYNQVHKLCQQSADAILKEFHPTLMIAIGGGGYVPARILRSFLKRPGDPNIPIQAIGLSLYEDHGRGDPEEVPGTKVTRTQWLDLSSLEMANLIGKNILIVDEVDDTRTTLEYAVRELEKDVEEAQKQLGREGEKTNFFVYVLHNKNKPKKGVLPADMMESGRYHASVTTDDVWICYPWEAKDIDEHDALAKENPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG51</accession>
    <name>A0A1Q5TG51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG51"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="307" mass="34604" checksum="9FD5C06E1DCD3544" modified="2017-04-12" version="1">MTLSPTIELDQTFHHSTPTHSYAIHWTSLGDPSSQPLIFIHGTPWSSRVWTNYAQSFSKYFHVYLFDNPGFGTSPLGKPLPDKEDTISEDLALDADLSQQSAVFAALFNHWSREWQQKPHVVAHDHGGLMTLRAHIIHGCEYASLCLINVVAIGPFGQPLFKLIAENESVFTALTGPVFEGVVEAYIRDASYAGLDRETTEVLKRQWVSTDEGRRGFVRQMVQANSRSTEEVEGRYDEVGRSMPVRVIWGKEDAWIPVETAERLKMKLNARDLVLIEGAGHLVMYDQEGKLGVELGWWLSHVRGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG65</accession>
    <name>A0A1Q5TG65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG65"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="366" mass="40417" checksum="2E0418790226120F" modified="2017-04-12" version="1">MHLCCSNNITGTTLNPHNRTLTPGGSSGGEGASVGFKCAPLGIGTDIGGSIRCPAAFCGGYGFRPTAMRNPMAGIQVACIGQETIHGVVGPMGSSSIEDLELFQKAVLDQEPWDDETSLMPVPWRTVTPTRDMTVAIMWDDGCVRPHPPITRALRMAKEKLQAAGIKVVDWEPYKHQRGWEIISALYYPDGAALQHQMLRESGEPARPLTEWAFSYSRPTPLTHSEAWVLQHSRDEYRDEYQALLKRRGVDFILSPANPATAAVMGESHYWNYTAIWNMTDMPAAVFPSGLTVDPELDALTAQDKKYVPRNAVDEREWNKYQSPERYESAPIALQIAGRHFKDEETLAAAKLVEEIINGNGMSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGB7</accession>
    <name>A0A1Q5TGB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGB7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="51" mass="5928" checksum="D05C9EAB60DB06A1" modified="2017-04-12" version="1">MFWGSSQPKEPNSPPPPDQDADKPVTREKLPTKLQHLVDREDDFYDDIYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGK0</accession>
    <name>A0A1Q5TGK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_8718</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGK0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGK0"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO99331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="626" mass="68681" checksum="EF803060AD6D0CEC" modified="2017-04-12" version="1">MSRPFPYTYISCPCADTPVLDPARKRRSRESPQKPPPERDTEANEGQDDAKQPANKDDEEDEEDEEQTFDPRSPRSNFSLYPPEQLLYCEDCHQIKCPRCITEEIVSWYCPNCLFETPSSMVRSDGGRCGRNCFNCPVCTAPLAVSTIENVTGNGNGQGPWVLSCGYCLWTTLDIGIKFDKPTNIRSQLQKMTDSTTGPAFDARSRQGSRAFGDLKSPLSNFASVDEQANPSERDAEQSTSKEDQTPTPHLGAEARFAALKNFYRTQISETSNSPSDSLGSEFGFSSPGALNRLMSLYASSSRLSGLYGGTKKPKSKPPVMREALTATEGLRIASGDADSALVERIASPDCGWDGVASLIQRTEQSPDVRFVDELLPLPVLLRTKRAKRCKSCKHILVKPETKPQSTRFRIRLIALSYIPLPTLRPLAQPSATSVSGLAPTPDLNALTPLRPYHVLLTLKNHMFDPVRITLATPSVTPGIVATKVTVLCPQFEIGANSDVWDEALQNATAPLSDRITGMRGGEKVPEAGKVWEKGRNWTTVVLEVVPGTLPGSQAEDGQEGDSDIAATFQKDEDVLEIPVFVHMEWDAEAQLEQQNVGKASKPDDLVARELAYWMVLGVGRIQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJM2</accession>
    <name>A0A1Q5TJM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJM2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJM2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="613"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="728"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1108" mass="123181" checksum="4E0E42AC5EBA4161" modified="2017-04-12" version="1">MTASSNNIDMATITETTTSVDMQSSQNQDIATRLLNGTFHASHPPFEQFATIDGLLRSHAAQPDDSKVPLICYPIRGAADFEEHTAGDIDRYTDIVARYYMERGLPPAVRIKASIIRIIQKTDHVQDPNLEEAPVVAILVGSSFEVILTMFALNRLGYAVLFLSTRLTAPAYARLLELANCTQMVIAKQFEQTEHEICQERPGCSSFPILQRADWFNRQASSPRFARSNVDPSREGKKIAWILHSSGSTGHPKPIFLTNLQTLANWRKSFGFRFFTASPLFHSFALMELGRAFYTRATTYFGNHSLPTTYQNLYDALQVAQPEQFSAVPYVIKLLAEKPEGIKVLAKPQIVLFGGSSCPDDLGDRLVAQGVNLVANYGATETGQIMTSFRPPGDNEWQYMRLHRPVADFTLMDEISPGVFECVALDGLPSKGPSNSKPPFSEKNPENSFRTADLFTRHPDPKKRNYYKYLSRLDDRITLVNGEKVLPIPIEGRIREEALVRECVVFGFQRTVPGALIFRAADKATDLNDEEFLDAIWPAVEAANARAETFSRIPRELVVVKSADIPYAATDKGTFIRAQVYQQFADDIETAYANFGGNGKKGDLALSVPDLEDWLLARFRDDLDVPLPDAESDIFSAGVDSLQTTQIWRYIVRDLDLGESADELSQNIVFEKGTVSALAKHLYQLRTGQESEAEDEVQIMQEMIEKYSHFTQHHPTIAQKPEKEVVIVTGATGNLGAFIVAEVLKRPNVSEVWALARAPGQVAAGARLWKALADRNITLTDDEAAKLRAVPSDLSQSNLGLDGYVLDYLLSSLTCVIHSAWAVNFNLGVRSFEQQHIRGTYNLINFCLRSKLPAPAQFFFCSSVSTASGTPKPASIREIAIENLNHAQKMGYGRSKLVTEHITRNAMRQTGMQARVLRIGQLGGDTISAQWNETEAVALMFRSALTTGALPELSESPTWLPVDQCAQAVADLAMKGATASQEVDLVYHLINPKSFSWKDDLLPALKQGSALPEFEVVSPQEWLRRLASSQQDPEKNPSIKLIDFWRGKYGKATEAQVDDSTPPQKAAGLDFETDRTVQDCPSLGLVKDPVAEGLIHRYIESWMQRWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJT1</accession>
    <name>A0A1Q5TJT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Telomere length regulator protein rif1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TJT1"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1301"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1343"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1360"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1411"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1459"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1472"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1556"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1571"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1633"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1745" mass="189870" checksum="D2499C909F2C9AD4" modified="2017-04-12" version="1">MVEILGPLPARPPTPPRPGSRLDQNDPQSPHPLQTPGASSQTADASRAPPSSHGSKRVNFSPWLYTVIGSPKSQSASIPNEAKPTTNTAFDSPQGSEGRPFKSILKETSSPIPVWSPNVNKFTDESLDMLLESVVQQLAGESISSRLDAYINFFGALRTYDGLLGGKEIGDKLGLITDFIQRDVTRDLVNGTPMDTSLANQALKLSAAFIWQSEISTQLSEEFKVFLVEHAITSLQESKGAKSVLTHYLSILSTQNFSPKIITTSRTTRLLTALQDLSKHVTGKAISFHRLSIYQRLLSQSKSTFLSNSSLWMEHLVFGLLHPHKDTRTKAISLGFQISVAAGPTHALSNSIRLLFERPLEGDRKLVTEIQERMSRMVASHDTGIHVPQIWSIVILLLRSKKWNLDQWEHFKEWVLVLQKCFNCSEPAIKAQAIVGWNRFIYAVSPNETTSRSLLKMLGKPVFSQFDRKKSDKSVLPPSQLALSSYYHLLYYAFRPSLPHYHLDIIWEEYVAAPSATTFSAFPALSDSAALVLANLLWCPQAKVWTESRITDTTKMEVEELPSVDSRWVRSKISSVLAVFEFLLKSSVWNEEAIEKSNIALAWNSLASALSLASSKEITPSGESMQAVASVLGLLHRLWATGTSSLNATGVHAEDAFFQRFQFLSTTMILSLGGIPFTEKLMLKIGDGAFQTSNTPTHRPSTSGTNLDSPILHLLRTISKSTVISSPTRSYVRLMDGLITAACNGRISRGSRLELLNQCVELSVTELRSPSSLPSLLEVVWKGTAGAAADALQSFPIESTRERDGSVSRDYEIITKILVAGVSFTGASQEWSRLLDAYMRVVRTEKGDRVLTGLVVEPISGILSSISVHDTYLPTNALLSHCLSIPFAWETELGIDNLAAQQVSSPAFPHKLLGTVGRTLDLGYDGFDASHSPHLSAFIESLTSFLGSGTTSFRAQALETLQAALAPWIQDTEGKIDVTRGVDSRAMTACRALSSAILNILQTAVVDEVTSLQKFETIICAGLESPDLSRTQQFVEFWKSTKTASNTQSPFTRMGQAFSTATARLSAPVQPPQTAVQETKLVSASSLKLANQRGNKQIAGESTDNGSTNFHSSPVIGTNDPALPDPAELGEPQLPTNLGAIAPEMPAAFQKSRREMFRMIESIRSSSPANTPGKLGFDTPIHLRRLHAQSGIPLTPTLAAAEHEDGFIGSSPTPATRDPTPAMNLEAPGGKFQDITMEDATDPPSSPPEFTSRSPSPKKMSSSSRRARRRKLLQSSVAEEAKKKASTPQVDERPPSRRTRSALTQNTANYQNAEAVPASTTASNTPAKPTDKLAAPQSAKSKSSSKKRKRKGASKPADEASQQAAQVPSTPVALEYFVDSSSEELESQIASQLEQDLVLAADMVSKGHSQPASAAEAPEPATKKRKREEDNVLSASQDRRRSTRLSSAKDLGVIDVDEVQSTQSQDATISQRSRLASASSLSPTVTRRSTRSSQKKEDELVIADSLPETQIPETIQEEPVKDPEPSQRPTKRSRKSLRLEDQPAPTVEEQSSTRAKSSRTSRSRKSRSSHNETQSQSLPSQEQQVALPTEATDSELLPASNDNQDAVPESIVVQKPVESKSHIPLVSTEEATDTQMTDVDPSTASVPEDTSIQRNLDVNIVPNQPLTSVAGPVLTLATAEVQTEPVPPSVEPDISEAGIAQSLKKLLANMKSAKLGPTALREVDDLLFNIRVEAHDASRRHNDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMJ5</accession>
    <name>A0A1Q5TMJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMJ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMJ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28683" checksum="E7580A17BF41E600" modified="2017-04-12" version="1">MKVSIDKHPKLASEGNMVLKLFDRRFVTEFRRVWNVDVWTPEAENKFHQFVNDSRSSKFLADIQRDKVNMSSFDMKMSAGQKVKAYDTLSDVQGAVVPRLIGLATASSSSSVSPGPLNQPTVIPGILLQYIRGFQLKDLGRHAPKELWNSICQDAMQLLRATGERGILNLDFQVRNVIVKKLRANHYKPFMIDLAICRFRAEAKDEEEWRQWRVDEDEEGWLGRGMEDHLDEDYVYRRSSYSKQLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ80</accession>
    <name>A0A1Q5TQ80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase/reductase SDR family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ80"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="28284" checksum="5D2FD425D1318A35" modified="2017-04-12" version="1">MAPKYTNKLANQRVLILGATSGIGFAVAEAAFEHGANLVISSSNEDKLDKTVSRLKEAYPAEFEKQTITTHVCDLSDAANLDTNLEQLFEAATDGGSIKLNHIATTAGDALNLPKLAELTPEAIYSGMTVRYIAPAMMAKFIPKYVESSPSSSFTVTGGMRGEKPAPGWTMATAICSAITGLARGLALDLKPIRVNVVHPGAVKTELFSMFPEEQLEGMLKIFRDSSTTGTVGKPEDLAESYIYLMKDEFVTGSVIESNGGALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQA8</accession>
    <name>A0A1Q5TQA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cryptochrome-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQA8"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF9">
        <property type="entry name" value="CRYPTOCHROME CIRCADIAN CLOCK 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="609" mass="69830" checksum="DE977F58CD7B029E" modified="2017-04-12" version="1">MKSGSASNIVVLYWHRTDLRLHDSPALHAALALEPSVFIPVWTWDPHYVYRARVGPNRWRFLLECQSDLSKSYTKLNPKQKLWLVREAPQTVLPKLWKKWGITHLVFEKDTDPYARERDEAIVRLAEEAGVEVVVRMGRTLFDPDDLVRKNGGKPTMSMAQTEKAAEKINRGQPDRPVETPKSVPDAWAKDKMDLSDIEHEFANPTPDLNADHRGSKDKQYSQIMGPNNDFGVPTMEEIGIDPALATTPHRGGESVALKMLADHISNEEYIGTFEKPKTSPAAFEPQATTLLSPYLHFGSLSVRKYWWDVQDVMTKRRKANQPNAFVPVNLPGQLLFRDMYFAAQAAVGAPYARVHGNKIVRFIDWHLQSKPHRPAEKDGEALPERDYEVDSPEAEEWFQRWKTGRTGFPWIDALMRQLRSEGWIHHLGRHSVACFLTRGGCYVSWERGAEVFEELLIDHETSANAGNWMWLSCTAFFAQFYRCYSPIAFGKKWDPNGDFIRRYVPELAKFDKKFIYEPWKAPIADQKKWGCRVTNDDSAAGGQSYPKPMFDFDKRRQICLDSMKNAYDVGLHGNDEQVLDGSWRKLFGENGGGEEPKKKRQRTGDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRN5</accession>
    <name>A0A1Q5TRN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRN5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="147" mass="15391" checksum="8CE3EA74CA839B3A" modified="2017-04-12" version="1">MAADAADMNEISEAFEEMSSSATRTTLTTVQATTTEPGITSTKTGEHTASSTESTSTTTSGLRCYHQCPTREECNCYCQGHVGEFQMMSSTTGMQTQPCAWTTLPPLDTKASVGPITSTQSNGDVVCGKSAHRAETTGNSAECVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUB1</accession>
    <name>A0A1Q5TUB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome regulatory subunit rpn-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUB1"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP03828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="353" mass="39345" checksum="8A47E784DAE7069F" modified="2017-04-12" version="1">MPATTADTLSLVNRSVTVAPLVLLSVADHYGRTAKGTRKRVVGVLLGENSGNNVRVSNSFAVPFEEDEKDPSVWFLDHNFVESMRDMFKKINAREKLVGWYHSGPKLRASDLEINELFKKYTPNPLLVIVDVQPKEVGVPTDAYFAVDEIKDDGTTTSRTFVHTPSIIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLQSLQGLHLRLRDIGRYLQKVLDHELPVNHAILGNLQDVFNLLPNLSTPSATQRISGQETQTENSELARAMSVKTNDQLMAIYISSLIRAITAFHDLIENKIQNRQQQEESDSKREQEINAAKGEKDGKKANGSATGEQKEEQDSSDKSKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U053</accession>
    <name>A0A1Q5U053_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U053"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U053"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP05853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="57196" checksum="036AFE8AA8B27D8C" modified="2017-04-12" version="1">MAPTMAIPVADPEAARDEKAISDHKEDLMTEVARDAAERGHLATDQYGHPIVEFDKAAESRLRLKIDLYIVPTVALMYLFCFIDRANIGNAKLAGFTKDLGLKGYDYNAVLSIFFVAYIIFEIPSNLACKWIGPGWFLPAVTLGFGICSVATAFVHDIHGASGVRFLLGMFEAGLLPGIAYYLSRWYRRSELAFRLSLYIVMAPLAGAFGGLLASGILTLDHFGGLRSWRMLFAIEGIITIGVAVLAFFTMTDRPETARWLSQEEKDLAIARVKSERIGTTEVLDKMDLTKTLRGIFSPITLVTAFVFLLNNITVQGLGFFAPTIVQTIYPHATVVSQQLHTVPPYVVGAFFTVLFPFLSWRFDQRLIFFVISPPLMMTGYIMFLASENPMVRYGATFIIASGAFAFGALCTAHASANVVSDTARSSAIGTVVMFGNIGGLISTWSFLPSDAPNYHIGNGLNLATSSMTLVLGASLWMWILWDNRRRSKVDVNAVLAGLSQKQIQDMDWRNPAFRWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0J2</accession>
    <name>A0A1Q5U0J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0J2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0J2"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010202997" evidence="1">
        <location>
            <begin position="27"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="35235" checksum="DB81870B000C14E8" modified="2017-04-12" version="1">MRLSLRVGSAAALIIVALILLSRRLGAPESPKDFWRFDTSSFRAALRPKPAQDVGRRKWGIGTGHSAVLTYQTSAIEIPNEGIIVMGKLREEDTAWVSAELAEWRNFVYTVDDTNAPAHTPKNKGREALPYLQYIVDHYNDLPAIIIFLHSHRDGWPAGWHTDTMDYSNVDSVRALQREFVLAEGFVSLRCQLSPGCPAEMQPFRQPPKPGNTGEKHYAEAWKVLFGNNDVPKEIGAPCCSQFAVSREQVLQRPLSDYKRMYDWVLNNDLPDEVTSNIMEYSWHIIFGKDPIFCPDTFQCYADVYGEEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1B4</accession>
    <name>A0A1Q5U1B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1B4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1B4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000453">
        <property type="entry name" value="MFS allantoate transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP06268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="503" mass="54809" checksum="50745914095EEC23" modified="2017-04-12" version="1">MDSKDAKVEQPPAVEKDVSLGEVRDIGADLYIEADQLSTEELESEGAAVLRILDWRIMPILYVTYVIQFLAYSLIPDLGLEGQRYSWVAAIFNFGYLFWAIPANLLIQKLPVAKYMGGMLLMWSVIVIAHVGAKNYAGILILRFLLGMAEAGVSPCMMVITSMFYKRSEQPLRMAIWLSANGMATMVGALLGFGLGHSHNTSLHSWQLIFLTIGLLNFVCGGVFLALMPDSPASARFLTHRQRVIAVRRVAENMIGVKTRQIKLGQAVENLYDIKILCCAGIGIACGVINGGVSNFASSLIKGFGFSGIYATLLQLPTGAIEAIIVPICGIVATYVPNSRCIVLAVVSLIPFAGLLGIRFTSLDHRWTLVGCTWLQYIIGAPVIVSWNLLSTNVAGHTKRAVANGIWFTLYAAGNVAGANIFFSREAPRYYSALTGLLVCYAGIIVLSIMAYMAMRWENMRRDAAAAAAGGETLTGNETQSQAILDGFKDMTDMESKHFRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1V9</accession>
    <name>A0A1Q5U1V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall proline rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1V9"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="96733" checksum="686359CBC625297C" modified="2017-04-12" version="1">MASISLPPQHRSGFSQHFDSPPPSNPDHNRRLTMGSPMPNPPFVFPARDPAAPESQPEPKQRRTPPALPAFSFNPGAGSTLQPPIAPTPRPGGHRRRHSEFVGGDQLVTPGAGESVDKREEPTTPTQPSAPSGPPPGRGPGRRHHAHRRSAAISGVDLNQINKALTSSAPSAPTTPGDRTFDDNTSRPLSYSATSLGRPTPPASPQFPSVPPVPPIPASIRIEPAPSTDDVDTGRPGSAVSYEPSPNAHIVKFDQPELPVPVARETPPNRRSKPRPKTADASLAFDLFQSKDVPKVPAVKRSKSTGHSRSKKSRSTGNLDATLAIHASDDAHSTDTSRPSYSDDGSEISDSDNEAGACPSSKKARSKSKKKQKRIRSWAGGILTRGKGKRHGKGDAEEKHEKHEKHEKKAKPPALTPPTLTRSNSEVGSVLEVDFDNDDVVVLRTPTNTDAPVSAAERAKDESPMPVPSLETAWKPRSFYEQNVQVGDDVLSSPIIDLDAALGPFNTPGDNRQSRGTPSKFYLATQRMYSGGRRGEFVGPEMRYHRRTESAPAMPPFDRSALSAIRLTGNSEMETPDVFYEEDEDAFLAANQSPRNELASSAPAESAMAILSSSSSDEDKKSVKSEDTADTLTKAPESSPSKPTGLGIQATEESSTQKEVPAVIDNGTAVDAMQTARNPFASQPRTPVEILKSEESVSKVLGPPSPDVSPRFLAIDKRPATSPQELLPSIPPFSLSAGVSPSDSSFPSPDAPRFNDRNFSSHSYQHLPSDYPYASVEDVPSLTSSASTMTGTTHRFSATFFPRARLSTDRAASFSAAVNRRSSQANASKRSSLASLSKLVGGPHSERSKLYQEEKPPGDTPEKSKKKRRISRLVHFWKVKDKEKHTEPTVSSDRSIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U250</accession>
    <name>A0A1Q5U250_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Regulator of nonsense transcripts 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_6501</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U250"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U250"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000003">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="69"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1087" mass="119361" checksum="53D6834B97214758" modified="2017-04-12" version="1">MDNYHPVLADDASVMADQDDNHMGSVGRAQPRRHDDEDEGSDILEDDDLESTVGGPVSHHKGHGNGEEEKELPAHACAYCGIHNPSSVVKCLSCNKWFCSARGNTSSSHIVNHLVRARHKEVQLHPASSLGDTILECYNCGTKNVFLLGFIPAKSDTVVVLLCRQPCAAMPSSKDMNWDTSRWQPLIEDRSFLPWLVSAPTDQEQLRARHLSPQLIAKLEEMWKENSQATLEDLEKATAVDDEPAPVLLRYDDAFQYQNIFGPLVKIEADYDRKLKESQSQDGLIVRWDLGLNNKHLASFVLPKLELGDVKLAVGDEMRLKYTGELRSKWEGVGYVMKIPNNQSDEVTIELRSKGDHKSVPTECTHNFTADYVWKSTSFDRMQLAMKTFAVDEMSVSGYIFHRLLGHEVAAAPMKTQIPKKFSVPGLPDLNGSQINAVKSVLQRPLSLIQGPPGTGKTVTSATIIYHLAKINGGQVLVCAPSNVAVDQLCERIHRTGLKTVRVTAKSREDVESPVAFLSLHEQVRMNDSNIELVKLNQLKAELGELSSQDEKRLKQLTRAAEREVLTNADVICCTCVGAGDPRLAKFKFRTVLIDESTQSAEPECMIPLVLGCKQVVLVGDHQQLGPVIMNKKAAKAGLNQSLFERLVILGCSPIRLNVQYRMHPCLSDFPSNMFYEGSLQNGITIHDRLRRDVDFPWPMMDNPMMFWSNLGNEEISASGTSYLNRTEATNVEKIVTRFFKAGVQPSGIGIITPYEGQRSYIVSSMQATGTFKKEHYKEIEVASVDAFQGREKDYIILSCVRSNDHQGIGFLSDPRRLNVALTRARFGLVILGNPKVLSKHPLWNCLLQHFKERHCLVEGPLSNLQESLIQFSRPKQAYRGPQRFHMSSGFNQGGAAAVAGAMNGRNGQRNEYQDTGSVVGYIPDDVSSVHSSAVGGVGLPSGYPPMFQNFADQWPSLSGGRRANGGRAKGAPSVAGESVAATESDVTGSIIDGRSADQGGVSLAGLSINDMSKQASLSQSDRLKRYVESGGREPYRGGVPDNGSIFGGSSASIRVTRGVPGHNVNDDDDARSVSTAFASQVGGNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2M0</accession>
    <name>A0A1Q5U2M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2M0"/>
    <dbReference type="OrthoDB" id="4270785at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="17851" checksum="02B7EE284F657DCC" modified="2017-04-12" version="1">MSHKRAWPFATKSIRSVSDLENYLEGLNTNDPLAFTPYYAPDAIFKWSGQPDRSINEFLDWVLDVHIAVTEKLSLRKAIFNGDGTVIAAEVTMQFQGNGNFETDNFVGKWGPVWPGNGPLVRAYVWYTLDKDGHIIEAIEDAHLLKAATRPSRIGKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5Y0</accession>
    <name>A0A1Q5U5Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Extracellular endo-inulinase inuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5Y0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5Y0"/>
    <dbReference type="BRENDA" id="3.2.1.7">
        <property type="organism ID" value="16768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051670">
        <property type="term" value="F:inulinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000003">
        <property type="entry name" value="Extracellular exo-inulinase inuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF1">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010319434" evidence="7">
        <location>
            <begin position="32"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="9">
        <location>
            <begin position="380"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="56845" checksum="BB587BD43709E9FD" modified="2017-04-12" version="1">MMTTVTRQPCKRHLILTFLFVSCSFSYLAVADDFRPTYHFCPDVNWMNEPNGLIRIDLDWHLFYQHNPDGNYWGNLSWGHATSTDLLHWNYQPIAISSADGIQAFTGTSYYDISNSSGLGTPDGLPYLAFFTGYFPSNRVQDQRLAYSLDNGTTYTKFQGNPIISQQQESPHDSTGGLESRDPKVFFHESTGQWVMVLAHGGQNKVTFWTSPDTKSWTWQSDFTSSSISGLPSGITGWEVPDFFELPIQGTASSTAWVLMLTPANGSPAGGNGVLAFTGSFDGRVFTANLVDPNNLWLDYGRDWDGAMSWENVPASDGRRVVAAVMNSYGTNPPTSTWKGMLSFPRTLTVQQFNGTLRFLQQPVIELHTVSGLLVDIANKTISPGQTLLSTTNGIALDITMSFIPTAGSTLSLAVRKGGSEQTFVNYTQSSAQMSVDRNLSGDISYDPNAGGVHVAKLQPDATGAVQLRVLVDTCSLEVYGGQGEAVISDLIFPSSTSDGLALTASGGDLYLQSVQVREVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U744</accession>
    <name>A0A1Q5U744_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U744"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U744"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="516" mass="57948" checksum="B5504F73E1CB2FBE" modified="2017-04-12" version="1">MGGIPWQSKGCRTCRKRKIKCDQQEPECARCLKTGIKCLGYDRDRFFVHQVTTKPKRSTNAGTSGGAAAADGGAASGSGPSKGAGKLQVMKRPPPHPQQPWIMPQFVASGPAMRSQMFSEFANIYFPQSIDTSYNLDVWHYLISGFSALPKKTQMLDKAIAALACFYLGKLRNDKRLFHHGIQLYNSAIRHLSTMMSQNNYCDDIVYTTIVFQEIESCYCPHGLHLFSTTGTGMSPEDYDYLTKPCDDRPVNGLMKFYGEASPIVDAINTVDASDHQACQTVLTKCIAHKDALMAWYAAHKKDFGGGPSECGPGTILNPRLPPTDNLFGASYRFSSLDNAKLHIVFWVALSISHRMIYEARGLVLSHTNTNQSSTPPTNRTQDEDLLLSMFYHDEIGRSVPYCVQDSMKSWGFSTLLWGLSQILNPYAEAGNWEKFAWCQNALMLGSERGYESAIRLSEIFWAVWHRVNPRQQRFMALALRDFDPQYLTIPKQHYMELVDRTVEPNLLDAPPEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA07</accession>
    <name>A0A1Q5UA07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA07"/>
    <dbReference type="OrthoDB" id="4500639at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="90" mass="10965" checksum="55E005459BE87F57" modified="2017-04-12" version="1">MTYDKYVRYEKYYGKYDKWDESRFRWDENNMPSKCTQLQVRYCCGHTLGGEFIKCARHIDSEDERCSNRYIHFIEAKQSTHKCRTCLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAH1</accession>
    <name>A0A1Q5UAH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000516">
        <property type="protein sequence ID" value="OKP09470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAH1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="359" mass="41170" checksum="40506D9398B5C8F9" modified="2017-04-12" version="1">MSIFDTLKRISQPGTIYIHFGKDQIPEEGVLQLQGFLRALRSRSVDLLPLNLKRQRLVQTTLNDDRLLPFPPPYSEKSASEQQELPPYCANSDSEVVEKWRLDSPPSLSENENQDRQVFPASQPLDSGTEVATPTNVSASSIVSPSPSPIRPAVFARATTRSRTHLDRIAGLERQLRGVPDHLIRRLLKGSGHSHLLTDLGDSDSDLSYESEKASFSKVQSNNCDSIRDYVDATVQRSLQSHVNEIADENCTLLYDLIRDFGEEFRSEAEEFYSGLRIETDECLRELEETCQESIDQMEERSQRCLDYIRDEGVTATEENIAKFRLSLRRYRHRRLRATRPGAPKHNRMQRYSRRRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBB1</accession>
    <name>A0A1Q5UBB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000457">
        <property type="protein sequence ID" value="OKP09768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBB1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="20252" checksum="54E07B82C141297A" modified="2017-04-12" version="1">MSQKTPGAEVSGKEAWRTTKTKAANKPTALKADTKVTAPNKKVTAPKAAKEATAPNKKVTAPKAAKEATAAKAAKKVAAPNKKATAPKATKEATAPNKKVTAPKAAKEATAPNKKVTAPKAAKEATAAKATKEATAPKAAKWRSICEEERTKYDYLTQDIMDCITRWLGDWSSKRPRCTQCSISSGSSISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBD0</accession>
    <name>A0A1Q5UBD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000460">
        <property type="protein sequence ID" value="OKP09767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBD0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="285" mass="29972" checksum="08D8776AEE3FB20E" modified="2017-04-12" version="1">MDRQVAIYPDLKGKVALVIGAGQSGDAISSYWGIGAAIAKVLSESGAKVIACNRSLEAAQRTAARIRADGGICEAIQGDATSQKDIKRVVDRVMTHFGRIDVLVNNVGRTLTGDAGSMSEEDWDAQICLNLKSVFLGCNAVLPIMEKQGSGSVINNASVAGMRYLGKPQIAYATAKAAVIHFSQTTGIMYAGKGIRVNSVSPGMMYTPLLEMLGNSESAAEREIYKKVTEHNVPQGSMGDAFDVANCVAFLASNASRYITGQNLVMDGGLTGSTGTGWSSQPRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBT2</accession>
    <name>A0A1Q5UBT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_4639</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBT2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBT2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="211"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="358"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="515"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="102"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP09927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="575" mass="63873" checksum="973A22232B8B87FC" modified="2017-04-12" version="1">MAATGSRQWGVTPPISTVLPTQDELVANDDLIAELKAQNNFEPPSDSERRIQMLQLLQRVALEFVKTVSRKKGLSPAAVEASGGKIFTFGGYRLGVYGPGSDIDTLIVGPKHVCGEDFFADFPPLLQQMAPAGVVEKMTPVPDAFVPIIKMELAGISIDLLFARLVIPSVPMNLDLKNNDYLRGLDEKEVRSLNGTRVADEILELVPQQKTFRIALRAIKLWAQRRAIYANIVGFPGGIAWAMLVARVCQLYPAASGSVIVGKFFRIMNKWAWPQPVLLKQIEEGPLQMKVWNPKIYHGDRFHLMPIITPAYPSMCATHNISMSTKTVILRELQRGGDVVDKIFTKQLSWSDLFTRHTFFTQDYKYYLSITASSKTKEDEAVWSGLVESKLRHLVGALDRKPIISVAHPFPKGFERIHVISNAEEMEAVKNGSTKYQAKGTTTETTDETKDPAHEAAAQNGMENAAVPVPTEHSEQKTEGDSQIFKSTCTSWTGYIPEIHDLAVTHVRNFDLPEDVFQPGESRPSRPKKKVIRKTESTGQKRRHVEMHDSSMDASQGAAKRQVTPNTVSNTATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBV3</accession>
    <name>A0A1Q5UBV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBV3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBV3"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="7">
        <location>
            <begin position="43"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="8">
        <location>
            <begin position="305"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="51568" checksum="C9CBFB9E23BDB898" modified="2017-04-12" version="1">MSQRRQYPTLPRESTLANLPAEYPTDAQDQISQILATSSINRLVVLDDDPTGTQTCHDISVLAVWDIPTLTTEFQTNSPGFFILTNSRALPPPEAETLIRSICENVLEAAKQTGQRVDIVLRGDSTLRGHFPLEPDVAQSVFGPADGLVLAPFFFQGGRFTIDDVHYVAEGDSLVPAGATPFAQDATFGYKSSNLRDYVHEKAPGRFSVKQLHSVTIEEIRLGGPQVVCERLLATPVGGVVIVNAAAESDMHVFVAGLLLAESKGKHFLYRTGAAFVSTRLGIRSKAPISAAELQLPSPRQTGGLIVAGSYVPKTTAQLKVLTDRLGAAGKLAIIEIKVEDLIASPETGSETVKQVVRETESHLLAGQDTLVMTSRKLITGADELSSLKIGSVVAEALVSVLQQIEVRPRYIIAKGGITSSDAATKGLNVKRATIVGQAAPGVPLWRCDEPTSRHRGVPFVVFPGNVGGETTLCELVEGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBW6</accession>
    <name>A0A1Q5UBW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000419">
        <property type="protein sequence ID" value="OKP09978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBW6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="14983" checksum="AB64D17BC061376E" modified="2017-04-12" version="1">MTTSHDTDVSEDDSLMAQANEQLERELLQSQKPTLATYRAPRRVVYLGISPSYLKDWMLQMVFGNCIKIDVHGAHDHLVGRHGEGLKLAALVLYRDRYNVSIAASGCNWKFDMHTDATSVSCTVAPSQKTKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC10</accession>
    <name>A0A1Q5UC10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000401">
        <property type="protein sequence ID" value="OKP10016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC10"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC10"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="45502" checksum="29A6F6900D81F137" modified="2017-04-12" version="1">MSTLLVTFGEIRGWKGAFHAHQFRYGGGKVINESGWVSKEQHMLIMKHASPRTFLDHYHPLQIDTDMIRVICGLDPDVELMRAVTRQSHWRDTRRPRYLTDHQRAQLEDHPELEEARRNLSQIRAQYEKTQQPALLPRIQQREKEVRNTRKRLQRSLRHQIRENFDEEQAFLDIEAQLSGTVVKEESEDESSLEDTMHPFQLYLVQSLLSYPISNSLEDEWNRRDTGAAAVVQYCDVLEGGPLRGRPKRNASESVTSAGPINQPQDAGQSQNVANSCEVPVSVAGKPSRATKEYLENSEKPEACFQCFANKGLADHVRFQMYHDAGCVTRHFDAIHLKEKPLKCNWCEVALLHQMAFQRHAFDVHRVRSRKRCPNPVQELQTQEQVRHDPLDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC89</accession>
    <name>A0A1Q5UC89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000397">
        <property type="protein sequence ID" value="OKP10096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC89"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8984" checksum="0DF40366021A681E" modified="2017-04-12" version="1">MAVGITPLGSVLESPLTPLPTEEKPLSRSAQSVVNFLQLHLVGHRPQPWWERRLKPDYYTQVLRVLDTDESLRNYVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDA4</accession>
    <name>A0A1Q5UDA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000316">
        <property type="protein sequence ID" value="OKP10478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDA4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="544" mass="61094" checksum="DB36A04C9543D5B2" modified="2017-04-12" version="1">MKAGVGRRFLSSFCKLRSRAAQDNQLRTPALPSSRSFLTTTTLPPGRKSLAIRTIKTLSKQMPAASPDFEHFFRYTSGRWLWDEEQQLRDRYRAFNVAGLQGLAARAVGSGGCVSMTKLAEGGFNKVFRLVMDDGKSVLARIPNPNAGPSFYTTASEVATMEFARDFLQIPVPRVLGWDATTDNPAGSEYIFMEEATGTQLGMIWDELSPDSKLSIMREVVAIESKMLSVSFSHYGSIYFASDAVEGAVPAKLTNEAPSELKEHIYKTFSIGPTVDRGFWKRERASMDISRGPWSTPSDYALCVGQREMEWIKNYAVPKPPSDATLVSPAQNSPEAHLQLLEKYLKVAPSLMDIEPILTRPTLWHSDLHSSNLFVDDGRIASVIDWQGSWAGPLFLQAQPSPLVDYQDHGKTRRLPVELAGNTWDDDIVSFREALINVERYWHELGIQGDCPYRFTQAELHNHSVDADGWNEVQDFFDSIEGLVKRDGWTSPETFDAAFGFFSELRKRGLAHLKGDERDIFERQTRWAKTQADLRASGMEQQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDD8</accession>
    <name>A0A1Q5UDD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000319">
        <property type="protein sequence ID" value="OKP10471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDD8"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="58597" checksum="801C5D8A6D6164DF" modified="2017-04-12" version="1">MATHLNATAVEVIIGYSFRSREHLVHALTAAGAEEHNHDGNRKLAHLGGNLLRFILSFVVFEIAPSRSGITNLESSIISIAQRASVAERTGIETFIKYSMKPGSRSPKVLALAIDAIVGAVYVDSTDVNASWKVALKLGLVSTDFLGSSASLAQPVPDIHDPSSSSSIRSDTVEDMEISLQPILSAGTPYNPDMLPPNRLTEEGLIGATSGHILPSPVNDFSYFELPMNENDPFWTSLERPSNGDQFVPEYISDGSGSQESACDFRGTDGTRDNPPPVARDSEENLVIFSGQRSNRVENSHGKPMRGQHYQALLIDDWLNSFLDEENKKCRSHQYPLPLETFFAPPIQTALIGMGAHAKTLTKFLVHIASAETLVTLRHIVLSYRERPSPSSYGTRPGLSEKDRFNIIGLLSTGIAWCRLLRMYHILELYETCKGTDCAEKLIVTTPASFQSRKRKAGNPRHAAEAEITERMTKSIFPDLLPGTDGYNEKKATLKRVRKLGQRLHILVAKFGSGILGLMLNDDMKGPDISEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE20</accession>
    <name>A0A1Q5UE20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">PENSUB_4022</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UE20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000025">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="24">
        <location>
            <begin position="1821"/>
            <end position="2419"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="23">
        <location>
            <begin position="2523"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="25">
        <location>
            <begin position="2845"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="2805"/>
            <end position="2831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="2258"/>
            <end position="2285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="OKP10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2917" mass="326749" checksum="D242915836E43496" modified="2017-04-12" version="1">MGEIYLDKALGLLSSDKQKERADGLAACHKIFEAIFRLVAVERPIYIRAQRSNTKNPSATRLSTCASVLRTAVDIFLHNIRAKTVRAIIDHITETIPVPRDGLWEPLSVDYTKSLTSLLQYPPHTEHLGDSDWERLIDYCLDVINIQESDGSQLSIRSEHRSAPDDLLDASDGRSTPQRMTPAPGNGEKFVGDRNTVGEVLACIQLLISSPSAPIQAAAESILRGLVEFVKSPSIMAGNAHKLALSSINTVVSRVLFDQSELARSSLTDLIPVIRRLWSTKLPSLKDELLATIMLCLVIFVDAAHKKPSESLVRSIEGLTGSLQSEYMKRSDRELLQADETVFYRKDGQGDGPVYGPRLGNARSEHSWTVIWALANLLKLTAKAAVQETDQAASGELSSKRQRLTSCIDDVFRDAISGTGAQRICALQMVPFLEAEIDIDTKESFVKRVIPSILDDNSTVSTWTMIALTSVVKGPSARHHQLKGYWPQAVDLATRAFSSTVTSRAACQFLSTTIEAELLEYSILSENIRSMLSSASLNGPSAISDSALSMWASIARKKLQLSPGTAQHASQQICSWLREVWTIGNVTDRLQTAQIATSARPLDLLNLFMACTNRPFEIPDIRYRGPSGLITRMWFYFHENAELLEYMFGPGSRILHSNPWNHGDTWSLKPSVGQDADDSVIIEILRAKSELFLQSWNTISEDRSLYITTDTLQILISFCIVCSLFEACLPQQSRSRVQGLQQNCNNIWNSICHFVSTHESTAIQPCLEIISPILVLESELEMFGIGAALCPLLRPLAEILEKLRQTSKEDSPNQRDIMDLDDRLAHHGDEVSVNQAIFASNRAACCLFSDAHTFQRCETIRLSILLRTQIEYVSLDDPLSTIVEYLTDLDESDLLSAQGALPAVYQRCSKLQQNELIQVLEDLGEKCLQSYEMERCEASHNVCIRMMTALVASWTDPQSDHLSESAMDLYSWFMEALISKKRASTNVYIALSALVQAVLELCPSYGNQQSLPSPRTTLFMILQEGDAQVKFSVADFLPTLFERFLLKDHDAIFDDVLQSLPRDPDWTEGIAIRLLVLSRLASKWHTLLRRSIYHMFETPAQAPDSLGYAQTCMASTSAALGLRDGRELFRLFASQILYTWTETQSVMSMPYGIFGYGTLEEMLIDVKDEVVGQMMMRAKESETQELASFLDIPHVELLEASFHKAEAYSIARDISTPPEQGSQPKGVEIRLRKLLGPERFMAQIEENFPQIIATFFRTLDRHDQIEREYSKRPSFHYALDIQTKISQKCASQNSLPANQQPCFRARYLLDELEFLCKRAGFELETIWSPALATFVCRSLLESIHPAMGSLHTCSVIRKIRVLVCLAGPIMLENYPLEMILNALRPFIVDIHCSEDAMGVFWYLLEAGKDYLLKNPGFTAGICLSTLVTLRRLFLSSPESTTQQSQFQGVLSTAEAFREWLRRFMADCQSSDRSNETRQYFANLLDLARQLPSLTNSSNFQIENDLVFAILKDRDSPTSLLSKPIADLVLSLLCPEFRGDTRDGNSSFESDLDPGSHIFSLWETLHKFNHCPEYQLWAARVIGRSFAATGKINERLMREQEHFLFQTPYSNDPTDPAHQSKNTILQLLCSKLHSQDHAETGLIEQTLQVIISHITEADDFQAYASIIPESLMPALLWNPYSCPKISLPRAKLEICDLGLQEAAEPAPLAEWARNATLSLSSATPQDPVIGPLRAVLHVVPGLAVQVLPYIIHEVLLSEDDGEGRLRQAISGLFNNILGKVSEETMPHARLVITCILYLRNQPVPGESTIVDRDKWLEIDYDQASSAAHQCGLQKTSLLFLEIEASRVISGSRRSSVAKYEPPVGLLHDIFKNIDDPDLFYGIQQSSSLTTVMERLEYESSGLKNLLFQSAQYDSEVQMSDSPNPFGVLRALNATNLQGIANTMLSASGSATNVLASFDSMLQAATSLQQWDVPVSPLDVSPSATVFRAFQSLNTSASLPEVAVSLDNCLLTTLKTMSETGQSTIELRNTMRALGIITEMSDVLQVSSAQEMKDEWEKVMARSSWLKTESYTEVGAILSWHEALFSSIRKNALLTSKSNLSSADSRLLEAKVFRQSLEITRSHGVSQASLKSAISLSKLAEPCAELGMNIDGAAKFDLANVLWDQGEMTASIRMLQQLKGQGDLHKQAIPLSRAELLVTLGHHVAEARLEKPESILQDYLYPAVKELKGVSEGESAGRVYHGFASFCDQQLLNVDGLEDFKRVKQLRDRKEKELLGLEEMMKNAEGREKESLKIFRAKAKQWFDLDDREYQRLLRSREAFLQQCLENYLLALRESEIYNNDALRFCALWLDQSDSKTANTAVSRYVNDVPSRKFAPLMNQLSSRLLDVTDDFQSLLTGLVFRICAEHPFHGMNQIFASSKSKGGKDQSSHSRFRAANKLVDRLKNDKDIGPTWIAVHNMNITYVRFAIDKPDNKFKTGAKIPLKKLPTGDRLGKDAETYKLPPPTMKIDLRADMDYNDVPSIARFSSEFTLASGVSAPKIVSAVATNGVRYKQLFKGGNDDLRQDAIMEQVFEQVSSLLKDHQPTRQRNLGIRTYKVLPLTLNAGIIEFVPNTIPLHDYLMPAHQRYFPKDMKPSACRKHIADVQTRSFEQRVRTYRQVTEHFHPVMKYFFMEKFSNPDDWFSKRLAYTRSTAVISILGHVLGLGDRHGHNILLDEKTGEVVHIDLGVAFEQGRVLPVPEVVPFRLTRDLVDGFGITKTEGVFRRCCEFTLEALRQESYSIMTILDVLRYDPLYSWTVSPLRMKKMQDNQDAGDGPPLLPGAQVKPSTNEPSEADRALTVVAKKLSKTLSVTATVNELIQQATDEKNLAVLYCGHLTCKRFGEFHGWGQPFSAGLEGRHQEMLRLIDVLNLSSNRSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE22</accession>
    <name>A0A1Q5UE22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoporin NUP192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UE22"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1669" mass="185277" checksum="D1A2ED92426A0F9E" modified="2017-04-12" version="1">MAELHENLASLRGLYQDLSAIPDSAFLNVERLVIELETHIQDFQNLLDKPAKSNASRQTVLSGKITVADIEYSINEDFQQGALQLADALNIDELEAAVMFLAAQDDSQVLDRSPLITAIMRFHERRHFLLECLRLIFREALEAEGPENIQPIMQETMALVLDTKNRQMQNASLFARKVLGSMGDVETWLSLLGDQVQKASIVGQEEDRDIMEAIEYQRHSLQQQHESLGAILLYLFKGTFTSAEDFRLLIAHLKKLDRLDGLLIHYFPVAIASFVRHGSPESSGTRAEARGLHDVIAKAADGQTWKLPNFHAAITALWLAIYSGWYFDDGPSDPVPNVDPEKEAEERTKMFMVSLDDGALELMLAICASVNSEEWADPARSELVALLLKESPINLPDSSSCSGYMKELLMQSFEVFVESCIANMPDAVRKLKSEEDNQRLDQITALRDGLTSSTNRGLVEARTHLESLLMIISFAFEHREDAAQEFWGDVEGNLYGFLQWASKRQTVPRVSAFCEMLCSISEGEENAAAAHRFLTEEDKFLTSKLKRSTNMNWIQMFAELHLYATRVTEKSPASGQTSHTAQGLLRARKPGPVDMSEPESPVMLTCYLRLMGHLCKQSGAIREWMLQNQSFKVAEELLMLCKGPIPSHLRATIFTTLSALMTDRTPGHGNDMWESINTFLISAPAGETSTLMKAPAHSNQSLWYEQQALQKIGESFDQTNAFVVLINSLVTPTSDLSEKPLSLTYPESLGAAYRMPGIEPYVDFILGHALSRRIQDLSGYQSRLLTFSCLEFVVTTLRTFNEDLVTVLSQPSLAESAAKASNLEAYVRLHAFSRVMEWLFNEDVLKALFAISQLDISEVAQASSDSVLVLTLLRSVEVMNLIMDLQSTYFNVVKPMVKSKSVGHRSTVANSSLASFEDSVLNNLSLVPALCLYCGTGHEQLTVTSMALLEKLTSSRKLNKMSTFEITKWQSSNKIVEVLATEVDVDSVARSLVAMMDPDLRELECGPRAAGYVIRESLLALLNSCLGMITDRPTVAHLLLGFSCLGNILDVPADGLFANRMSLLHAIIGFLQAYPDELDGTITSYTVHLKRMAFEVLKHLWSSKLAFYFTLTEMRAHGFLMNMFAGQPIIGPNTPWNGHPIFTDEFWVTDATSALAEFLLYRSHLFAYAATEIRSAAKVGSPTLQAGILSTLLGSSTLDNGESVSNASVFDLFDFADLDVSRNFQVPRLIFLNNIGIEDCASQERDTLVLYDISKVEELIHIRKSELLATFPGRPHAEEQFDTEAEGLKIFILATNQSRQISYNRYLALRSWAELVTTITTCSVLDDATRPTFILHAIQMILPKLEISIESESLEAIELARLGETLISKLASDLPEAPTSRSGDVIDEKLHQLFQVSVRGIMLASGNVSLREVLYSICSHYITRITSSDIAHESLRRHSQQIVKTAGPGLVEAVCDDAYTGQEACRASALLFLNCLAALDSRTDCVLAELISQSNYLSLFLDAIRSLPVELRNAQAADTSSLLAYYESLLALLQQLSQTKSGATYVLKCGLFDSVRESQLFAADPDIGIDIDNPDALRKYYDLLLCVIRVIVSAVFSRGAHNEQIKAQTRAFIAENRPCMVGVFKRFAKIGGSTSATHHEALCELVKSFMALVTATDFLEVCFPLAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE56</accession>
    <name>A0A1Q5UE56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADP-ribose 1''-phosphate phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE56"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27002" checksum="2687E01C1C5D0A98" modified="2017-04-12" version="1">MTSNIPEILLLCMESEFITAFDEAIQTHWPDFTPDKVKITKFNTRLNSLPPSVKFDLVVSPANSYGRLDGAFDHAISLAFSPRKDYHALTRAAQSVLYDKWRGYAPPGSCTLVEFPEDLKQNVRDCGWVAICPTMREPENVNWDREVVYECVWSLLCQLEGHNRRNVDNRIDTILMTPLATGIGKVSKERWAAQAVLALKHFVDSLEKPEEWSSLQWDTIEKIDDEVRQTWMPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEF2</accession>
    <name>A0A1Q5UEF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="411" mass="45244" checksum="E31468181F5B1179" modified="2017-04-12" version="1">MPTMWTQKRALRASCDNCHQAKVKCIPTASGCQRCLGLNALCIHSPPGRSGRAPAARPRSSGGHQQARQPLHVPTPPQSNPSQPLSEFNDLTHLRNSDNDEDIHTQGAHSSVDYFSTIVENEAHTIEPIDPMLADWFASSSVNPLQTGDPGGSMAESSNFYTSSHGTATPIPQATSDFVPGVASTSSKTNLQSLSGTQRGHAFFGSNSQESLCACFHSIIRALEKIQCANLRLLTLDVALTQNKEALLRVCNALKCGTPHDSTTRLVILLLLRKNLHFYHLIYQSRLRDRREVNNETPNASTTSLWSSLESHTNQPSQGHDSVFFTRQIHGHNSQGRNSRLTLGTYQLEGADEASLTKHILLLDVKKVPRLLERLDQRACGLDEADGLDMYNIMRSALIAEFRMVMMDVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF61</accession>
    <name>A0A1Q5UF61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF61"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="37545" checksum="837C7046538C8211" modified="2017-04-12" version="1">MQVWSIDSEKQIGTQQQQRSSSISIYSPSAHLPLTRRPKSISPSNQSVGEVRNPQNCDTVVLAPEKLLASPTTLKTAADAFRTVMDLEQFSVIHTPFMLGPSFVPEAQKTVYTILYFSAPTLTEGYLAFLGLMTRYQRSLVMRQDEPDMSKAAKGLQRLRSVKINQDYDAACALFLGQTMQLADIERSILEWNPPNPPELLEKHGQSEVLAMMTQASAYRLAALLIIHRLRYPLGVEEKTARDLANRIFSIMTHFAQTAAEKTTALPVVFPLTIAMFEVEGPGEELWTVFSPFAVQSISAARLHGFIKQVRASKESGYEGIWFDLIETQLHVAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFM7</accession>
    <name>A0A1Q5UFM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFM7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFM7"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="55"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="51317" checksum="5817A868376DAB96" modified="2017-04-12" version="1">MNADEISANRDANAGAEERKVQPIPPLDERDIKLGYMSEADRHVYESGIQKFSRLGWKRLTVVLIVEAIALGSLSIPSTFATLGMVAGVICTVGLGLVAIYTSHIIGQVKLAFPEITSYADTGRLMGERLGCPRFGYELMTGMLALQLLFLTGSHCLTGTIAFLNITKSDVCSVVFGVVSAIILLLLAVPPSFTEMAILGYVDFASIIIAIGITVIATGIDAHHSPGGLSGVNWSAWPKENITFSEAFVALTNIIFAYSFALCQFSFMDEMHTPRDYVKSIWALGITEIVIYTLAGALIYAFVGQDVGSPALLSAGSLMKRVAFGVALPVIFISGSINTVVFGRLIHGRIFANSHIRFINTKMGWLTWLAIITAGTIIAFIIAEVIPFFNDLLSISSSLFISGFTFYFPPMMWALLLKKGKWSEPKNIMLGLVNLGVFLIGMVTLVAGTYSSVDDIMNKYKAGTVHGVFTCGSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFZ8</accession>
    <name>A0A1Q5UFZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFZ8"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="6">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="218" mass="24506" checksum="0140DE9973352172" modified="2017-04-12" version="1">MAPKLSKSDKQDLILTHLRATGTCHTLKDLEKTLPTVASINSIQVKEYIQALTDENNLRVEKIGSGNWYWSFGSDEKHERERQLAWVKADVEKARKSCTDAEAGLAAESTKRQQECDDTSCDAERETLQGKKANLREEMCRLQAAKMSATDSVSNKGVQQLQAELAGFREQALQWTDNTYVLEEYLRRLAGGNGELVEAILRECYGDEYVDGEGLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGR2</accession>
    <name>A0A1Q5UGR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Survival motor neuron-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGR2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGR2"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="165" mass="17969" checksum="5D6CE138AC09E202" modified="2017-04-12" version="1">MGKSKHDQSLTHEEIWDDSALVQSWDEAVEEYKLYHSIHAKGENIEDVLRGAEGAGLDEEQNLLDEGDVIAEDDAMVAESEPAAAHFTQTNDPSAQSNPPVAEGSGPTINPGPSPTFPAGAMPMPGAVLPHVQDENLKNLMMSWYFAGYYTGLYEGRQQASQPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH75</accession>
    <name>A0A1Q5UH75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012411795" description="Antigenic thaumatin-like protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18420" checksum="2F28123004083655" modified="2017-04-12" version="1">MKTSLIPFGVLLGLVSAQNAVVNNHCDTTVYVQSFPYDGSAPGPLTTVPHGGTFSEAFRASGSTVKISKTKTLNQPLFFGYSFSSNPDYAYCERTYSTCQRGNFINRILLQDELSTEWGNPFAAYPNSLSPGDGCEVFDCAANDAGCYSTPAHKKVYGCPQPVTLTADLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI27</accession>
    <name>A0A1Q5UI27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like-specific protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI27"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="241"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="456" mass="51398" checksum="495CC53E02EF8244" modified="2017-04-12" version="1">MKRFLSWICRRPEPEPVQDGVRSAGAVDPLTSSKIFEKIQKDEDLYALPIPGAFPPSPSVSPRLAPRDEHLEEDYVLVDTTQEIGVDVSTAPILHTDLGSYLHPRRPKYTPSPQRFRPAEPATAKPIRRPHFQDDQAIEDPYGRKYKAYEKLPLGRAMSAVSLFYPEQKPLPDNRIASILAPEWEQREKERKALEGLAGRSTRIIPRGPAVRPLSREWIMKVSEAMRTLQGYAVARSPSGDDLYQKDIATCIKPLAWLNDEIINAYLTVLVQYLRQSTGNTASGERPKFHAFNTFFYSTLRDKGYQGVRRWANRAKIGGEALLDVDTVFIPVHQASHWTLMVVRPVDRTIEYFDSLGARGMREVEVIKKWLAGELGNKFDAEEWSFLPSVSSHQDNMSDCGVFLLINAKAIALGIEPTAFGAKDTVDLRVKIVAELMNGGLHGPFYPVDKMGQTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIH3</accession>
    <name>A0A1Q5UIH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIH3"/>
    <dbReference type="OrthoDB" id="4540708at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="240" mass="26923" checksum="1FCA58777031166D" modified="2017-04-12" version="1">MQMVWATSLMQQPLLKKGLEWVRMRHVRAWSLAEYIKPPPPIPVARLQALLNFDSTAIEPSDVLVKSISLATESMGTKILRLNATVSDGRIIVSFSYPPSAERYKKYLEKPESSYDDNHKWRSTISGGQVSMDLPAGITFEFPSGSKDAVLAFADEAKATIWEEKMILWEKSANQEGTKRSISRSLTVERLNEKLGLLRNSSEFSHVSFACSNYGYQLGQIHGHMTLPAAPWTKFKGGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIM5</accession>
    <name>A0A1Q5UIM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIM5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="638" mass="71542" checksum="BD0FEB7F4B25C513" modified="2017-04-12" version="1">MAEMGALKMDNPLPSPAFTNNHHEHTLKEESWKHRAPYQIQSPQEFGPVKWRAKCKCGKISYTLRQDKPLNAKFCHCRGCQVMHGAPFQWAAIFHKEDVNFAKGCKSSVIFRSATTDDKWTYNGLRKCAEQFGRTLQSSWRWAKDDVLMVMAPNDIDTPPVIWGCLYAGGIVAPVNPGLSIQDLHQQIERSEARGLVVHPDCLPVALEAAQIANLPPERILALRFDRDLPVNYGISTVEQFITNGQVPSVMVRYRPRIDSQRDTAFLVYSSGTTGLPKGVMISHQNVVADVFLQSLVESAHIDWRQDRTLAVLPIYHIYGLVCLVHAPLYVGTTTIYMDKFELARFCRSIQDYRITHVYVAPPIVLHLTKSDQVSDYDLSSLRMITSGGAPLPANLITELYERRKLAVRQAYGLSETTSVTHIQRWDDWKNGIGSNGPPLPGVEAKFVAKDTRDAASGEEGELWIRGHIVFNGYRGEPELTAGCMTPDGWFKTGDIGHEDKQGNMFITDRSKDLIKFKGYQVPPAELEDLIIKHEVVEDVAVIGIMNESLASEIPMAYIVVKPGIPEDETTAKLVLDHVKNQTVNYKHLRGGIIFTREIPKGPSGKILKRVLRQQATADAVRRIGAMEYGKYGREAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJR4</accession>
    <name>A0A1Q5UJR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carcinoembryonic antigen-related cell adhesion molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJR4"/>
    <dbReference type="OrthoDB" id="4369169at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="33539" checksum="E9647D37AA3390DC" modified="2017-04-12" version="1">MSTSAIIYPADTHIGTVTSFIPLTTTWTAPSGCYTKYRLDGPSLMAFDPAYGLDVETGLVCAPPAMTTWWEQGLLGGGGGGDSYRTRISIGPISCPKDWPLLASSTKDSSSVLSLCCPSGFYLADAVPGSVGGNCLSDVSSGMVLTYGSTASGDSTSWAMATTTLTASSTVGAIGIQGWNIKYQTTATSTSTTSTTTQSSSTTPTTSTTASAASQNLPTSSSSSGSGLTIGAKTGIGVGVGVGAIGVIALLAAFYLFRKRNQGTEPELAQSLYPHYSQPPSMSVPPAEYYQPQYPAELNAIKLRPGEGGNPPAELPSRNWASRSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJY1</accession>
    <name>A0A1Q5UJY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent malic enzyme 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJY1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJY1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="3">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="3">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="186" mass="20721" checksum="C5D38471071262CF" modified="2017-04-12" version="1">MDYVKPTILIGLSTLGDVFTPNILGKMATWNTAPIIFPLSNPSRSLSVTSSVPLKPMAALSLLLDHPFRRSPSPILSARLQHTPRAKETICKALSRALDEDEIARGLIYPDISRIREVSVIVARNVIRTAQKDKVDRNIAIRDMSDADLETWIKARMYDPHSEVQNFESQISGLSSSPHICYACHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJZ7</accession>
    <name>A0A1Q5UJZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THO complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJZ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJZ7"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02239">
        <property type="entry name" value="Cytochrom_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="374" mass="39421" checksum="BE390D6C48A738B3" modified="2017-04-12" version="1">MAPAPRRDLLAKEHFAFVFGGVKTQSYYDPAAKGPGSHTIRTLAWNPTGQLIATGSADRTLRIWNPERPAIKYSTELRGHSAAVEKVLFNPVRDAELASCSTDGTVRFWDVRSKTCVSRLDVGGEAFTLSWSADGSTMVVGRKDDTLIPISVQSPSTPTILSTGVTTNGVSSLGGSKPGASTYTALTPHPQPIQTNATTFSNHVATPTSPDLHLFATTGEGSVKIMSYPSFDILHTLHAHTSSCMAISLAPTGRYLAVGGSDALISLWDTTDWICRRTLSSENGGSIRGVSWSFDGRFICGACDEPFCGGNGLEIFHAETGESVYTIPTTGVNVGVPAVAWHPSRYWLAYSTTHDGPGSGSGGLKIVGAAGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK84</accession>
    <name>A0A1Q5UK84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Versiconal hemiacetal acetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK84"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK84"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="347" mass="39318" checksum="2A7B108D67BF7D8A" modified="2017-04-12" version="1">MSGKEMEYTRLGKSGLKISRIILGTMGFGSKDWQDWVLDEEESLNVIEHAYKRGINTWDTADVYSHGRSEEVVGKALKKFNIPRNRVVIMTKCFYGVDDEGKFPPIWQSARNEGDFINRVGLSRKHIFDSVDASVQRLGTYIDVLQIHRLDRDTPREEIMKALNDVVESGKVRYIGASSMAAWEFQTLQNIAARNGWHQFISMQNYHNLIAREEEREMIPYCLDSGVGLIPWSPMARGVLARPWGSRSTVRENTDGALKVLIRNRETEADKAIVDRVEELAGKKGVSMAQIALAWSLTHQNECPIVGLHSAARVDEAVASLKVQLSPEEIQYLEELYVPKTIAPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKJ0</accession>
    <name>A0A1Q5UKJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000160">
        <property type="protein sequence ID" value="OKP12982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKJ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKJ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="269" mass="30611" checksum="4EC4C25FCF92B6C8" modified="2017-04-12" version="1">MDASKTKLGVDHPDTLTSMSNLASTYRNRGRWEEAEQLLLQVIETRKTKLGVDHPNTLTSMSNLASTYWNQGRWEEAEQLFVQVIEASKTKLGVDYPDTLTSMANLASTYWNQGRWEEGEQLEVQVIKASKIKLGVDHPDTLTSMANLASTYRNQGRWEEAEQLEVQVMETRKTKLGVDHPDTLTSMANLAVTYWNQGRWEEAEQLEVQVMETRKTKLGVDHPDTLMSMANLAFTWKSSGYNTQALELLRDCLAKQKQILGLNHYVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKK0</accession>
    <name>A0A1Q5UKK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP12992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKK0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="124" mass="13414" checksum="186F371CEC0F917C" modified="2017-04-12" version="1">MLRYDPQSEATLSPIVLLVTHATSSSSTPASEDDPKADLIREAIAQKQNGQYPPMPTFSATIPLGADNLADCVTHDPIKARAKPKRQSSCDSKEAPYGRTCKDNIKIAILAVADIIRDAYETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKM6</accession>
    <name>A0A1Q5UKM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKM6"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="840" mass="93457" checksum="A3DA61444B4BC530" modified="2017-04-12" version="1">MATAHGSTTHLSTGPLPATAPISADELKEYERILKISDEIFAGSHPRLKVPQQFVRKPVARNSQHGHPAQQVAKSKHFGVPAGNVPVSNTAQRPQTSQAPPAAGNAPTTSVLNAAAPPFRMAPKPTSEIDPIFLTKSDDLVRAEIQLQRQRVERTLRDQIEQKKLDSKLKPAIQDTKPDFDVSDVLDRALEIVRPVSLSDPSEVNGPNDSFDENSFYSSRAPDSPQPAGAHRKSSPAAPAQPLSSASRVPVDHYADELQRLEALNRSGSDQEMHDAYPVVDQLAPNPSKPTLSYQPKASGHLHELQLADAPEEPEYSPPAPVAPPTDPRHYERMATGDDRGRYADRTQGIQGVTSPATNVKVVRNHITSPAAPRPSRVSPLATAKVPSVQQLRGGRPERGSEQVYSDPDSGRASPSGPAHQVMSRKRRKLHGKEDTRLVSHKSQNAGPSDAYIKAEPVSPPPFADDPAVNPSRHPQERPVYIDIASPQYTPVVERHEPSVRGPAYELNPYHEIPAEQGTLRAVSQLGDRRVVRDDSDLRRVTTMQYARQPEYPRGYVETEPRGGRAASYAVVERLPQERPRYYEEVPSSYGPRYITVDDGHQPAYQDPYYEEHPPVRVMAAPERRFVVDEHGNRFEMVPAPRMQSMAPPPRPMSRAPKADVYSDHVPVRTASARAPSVIQDPYGEHRYVQEMPPPPPTYRRVVSDYARPVAGERRAYATPLESHDPYAPSEGVQLAEYVPRRPAYVEDHAQPLERVIRTSSVRPQPVRYEEPLEVVQRVGSVRPVGPSREVSVFLDDRQRGEYIERPYYVREQRYYEGDDGNRMALDGPADSVQRAQPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKR4</accession>
    <name>A0A1Q5UKR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKR4"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="361"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="608" mass="68235" checksum="BB1EEF7D49EC7737" modified="2017-04-12" version="1">MVSSYPRPDFQRKGLNWAPLDGTWDFIFDDTNIGLSEKWQSKGVPPQTADKQPKREIKVPYAFQTPASGIGLLEAHELMWYERRIDDIRTDSEKAQGNRLLVRFGAVDFECSVWVDGQFIGGHRGGHVPFDLDVTDAFASDAKSARLSMRVRDSPNDLAQPRGKQYWKPVSENIFYTPSGGIWLSVWMESVPAMRLCCGSGGTVLRSDDIEHGELHAKIAVSGRSPQAGCSVEVEASLGGVPVSKNKVPLPSERDWAALDLSMKVPHMKELQKKEPYNTEGAWHNSVALWAPEHPILYDLVLRLYDASGKVVDEIEITTGMRSLSWQSGDGTFRLNGKPLFQMLFLDQGYWPETGMTPPSSEALKADIIMAKDLGFNGCRKHQKVEDPRFHYWADRLGYLVWGEMANAYEFGSDYIERMNAEWAEAVKRDINHPCVITWTPNNESWAYTSLKDNIDQRNHIRSLYYLTKTLDPSRPINDNCGWEHVLTDLTTYHDYADSHDLAETCSKMEGGILGQKAGREMFTKPIYSGFSGHTLLDPGTQHKAGAPVICTEFGGVNIAPPKDSHAGERDWGYTTATDVEDFLKRFEKLVMAIVKGGHTCGLVYTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL74</accession>
    <name>A0A1Q5UL74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL74"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="441" mass="48243" checksum="907DF71ECB61EF79" modified="2017-04-12" version="1">MAENSPNPVPFSEPPYLRGLPSPYITPAHREFQKRCRKFAWENLIQHAMEWEKAGTVPEHVFGTFCKHNMLLPNMPAPLPVDWLKRLGINDILGVKVEDWDYIYTGIYCDELARSGLSGPGGSLNAGFAFGIPPIVKFGSKELQERFLPDLLTGKKRACIAITEPEAGSDVANIVTTATKSADGKHYIINGTKKWITNGIWSDYATMAVRTGGPGPTGLSVLVVPLKNHPGVTMRRLKVAGQITGGTTYIELDDVKVPVSNLIGKEGQGMRIIMTNFNHERLVISVGVTRAARVALSAAFSYCLKREAFGKTLMDQPVVRHRLAKAGAELETMWAWVEQILYQLCHMSKEESDIQLGGLTALAKAKSAMVLNECAQVAVLLFGGNGFTQTGQGELVEAILRDVPGARIPGGSEDVLLDLSVRQLVKIYQAQEKMLSKSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL82</accession>
    <name>A0A1Q5UL82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposable element Tc1 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000154">
        <property type="protein sequence ID" value="OKP13231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL82"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="65"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="21998" checksum="3CB683C982DA7F9D" modified="2017-04-12" version="1">MDFGSGWVWRFTSEAYRRGLVNIVPHVRDISQMVWAAIWLGGRSDLVIMERDESAARNGYTARSYIDALGEGLVLHYTPGTIFQQDNAKIHTADIAKSWFESHGIEVVDWPAHSPDMNPIEPVWRLLKLKVFSMFPELIDMGRSEAGWQYFIECLKAAWATLDQAKFDSLILSMPRRLEALRVARGWYTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULC8</accession>
    <name>A0A1Q5ULC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="9">
        <location>
            <begin position="175"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="44623" checksum="84892549D732DAB7" modified="2017-04-12" version="1">MALDAMDLDTSPAPTDVERKRKHKNKDASPSKKRKQVDQTADKTKSKSSSKKDKSSTSSTGAGAGATTAGTPGSPFSLTTATLYLPLAPISISSNVALQSLLTEHISPLLLTYYPPLKGIVLAYSHASISATPPSSTPRNSSADPNPKPLTMARSADEYGVLYVYLTATFLVFRPQRGQTLEGWVNVQSEGFLGAVLLNLFSVGIERKRLPTSWTWVPPGEDCETSEGAVKDLTTDDESGVNAVPPSFDAEKELFQPAALAADELDIDGEAEEEEAASGHFQSISGHKVRGNIKFRVVDIDVIPGSERDRGFLSIEGTMLTAEEEEALLAAERQGQALPPSFLGSPRRKNGRIVPISSSPAADAVVDVSVVEIEEPTGESVSVSEPVEKKKEKKEKKEKKDKSKSKKEKKEKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMF1</accession>
    <name>A0A1Q5UMF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0613 protein PB24D3.06c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMF1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMF1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF1">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="33205" checksum="F7FB0B9B76EDA3BB" modified="2017-04-12" version="1">MADLVRALQPTEWSLFTLNLTSSYQSWGLGHLDRDTDEIAQCLNYIKEYKTSKFGNGKIVLMGHSTGSQCVVHYLSRPNPHTSTPAFDPDLEHILRMPLDGAIMQAPVSDREAVQWVLSEGIGGKTGDEIRPIYEKMVAMAKESVAKGEPHDTMLPLWMTSHIYPSNTAISCRRLLSLISPDSPQSPGEDDLFSSDLSDEQLKTTFGMINERGLLKHKLMVLFSGADQAVPEWIDKEKLLARWRGITDHNGKYEIWDQKHSGIIPGASHALSNDDQAKPREFLVEKVLGYLKTAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMU7</accession>
    <name>A0A1Q5UMU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMU7"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="328"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="53403" checksum="A9B2EF3537E07AA2" modified="2017-04-12" version="1">MPRTARQSALLQSQPAIQSFGRATKAGVTPSLPAKKTASLPVSPSKKRKLQELENVDCAGRQSLDEEANTPSKTLKISQLSVSSPRSGHYASPKRTPSRRTRVSTVAVANIPEVPDTPSKQRTINFEKVIPEPKLAPQAPCVNDFLGLHYAFVQALSIHMAHNGPISPADFRELLPSVTRIWKKRKVQPKDLQRLLWVWDHSLKAKDVSYRLANYGLGKVCLERTVQIDQQPPALQDAFEQALDLLWEQTEPSLEIAKEEDRPALFLESLGLAPIHESLTPFTAFKKGQQRLQDLRSGVIRMKTEKLRAEAEIGESKPLAPAINRRQSLLDRIKNKELRQSKLPPPPTKKEVTRRAAADRVEEVAGILALLRPAAYVGTGIKAMFASQRKPFNMDTMVDHVRDSVRIPIPRDEVEACLEILADPRVAGHWVTMVTVKDIRSVVLKSCKDIAVNQLGAKVAQLKAEWEKPQACVSSPLLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMZ9</accession>
    <name>A0A1Q5UMZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMZ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMZ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="40966" checksum="B54C6FE03445D8CC" modified="2017-04-12" version="1">MPVYGGFDIAKTFIMCPMILNRLSDGPAMVLSPSQENAFGQLPSQSLLDTPGSFHTYPGNFNSSAFGANSFAQPAVNTNVSAAPAPPKPSRKRSRDEAAFDDALAVNAPPQPQPASARKEEPIYGEGMVLLNPQTGLAVSAESQTGTWYEEKTESQQATAAPISSRSIAIQSDGADISRKAQRLDTSAPGLDDIALASMHQRLNGSDMADQHRTAPATPPAEPLIDDATRLLGISWQRIDTDDDMAPAVRGWTKYIDNQYAAYLHHSQMLMKSRALNAYLVAAMPVSAFSPAFYLFNEDLTQGQLVASSWESCLNNLRSTPPVFEGAAPLAAASRPQPAANPFTAASASGVPLLQQALSSHSHSPTCGMDAGAGLNGGVEMGMEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNH0</accession>
    <name>A0A1Q5UNH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNH0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000528">
        <property type="entry name" value="Nucleoside-diphosphate-sugar epimerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="467"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="776" mass="87732" checksum="E86BF11659C2513F" modified="2017-04-12" version="1">MSAVLITGATGKQGGSLIKTLVSRKSPLEILAVTRNPQSASAQKLAKLSSNIKLVEGNLDDPATLFQNARKATQSAIWGVFSVQLAIGNTTSEDAQGKALVDEAIKQKVQFFVYSSVDRGGDASYTSPTEIPHFINKHKIEHHLVEKSKDTDMKWFILRPVAFYENLVPGFMGKVFATTYKMALKGKPLQMIATDDIGFFGAEAFTHPEQYQNKSLSLAGDELTYDQFAQIFHQKTGQPIPTTYRFLCSILLWAIKDMGYMFKWFHDVGYKADIAELKKINPELKDFATWLEKDSEFAKHIYITDDTSYNRIPQDIPVSVLCDVFAASAAIRYLGHAGMHEMIAHCMLLELFQLLNPKLKYMRNAYRRPCMWTSEYFPVPKPPRERYQQADAGLISALEEQRAIRAIWQLLLVCEVHTLVGGPSPRWNWPCEEISRLQNMDFEGLWRHALRNNALEQARTMTECSCKQGGSVINAILREDADFQILAVTRDASSSGAQKLKAKSSKIQLVEGNLDRPEEIFSNAAKLTSQPIWGVFSVQVWPYSSFWSYRPPLMLNSGACAWWLQHDAEEKQGKGLVDSALNNNVGHFVYTSADRGGDASIDNPTSIPHFISKHNIEHHLIERAKGTGMTWTILRPTAFLQNMTPDFFGKVFTTCWKIAVKEKPLQVISVTDVGFFGAQAFLLSGEYTNKCLSLAGDELTFAEMEKIFRAKCGRDVPLTFNFVSRILMWMLNEFGYMFQWFYDSGFRADILALKKDRPELHNFKSWLESESGFVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNQ7</accession>
    <name>A0A1Q5UNQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-1,3-glucosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNQ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006740">
        <property type="entry name" value="DUF604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04646">
        <property type="entry name" value="DUF604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59996" checksum="4CB7B901AC70B6BB" modified="2017-04-12" version="1">MPLFRLKTVFPLIALVSIGVFFFCMERYDRSAFLRFKHPIDRLNLGNSQTQLGSPAQGSTPAADTCEVDPKLAAPLPFSEWLPRKNYTRAYFRPRIVSPETEFHTLEEVEKPVLPPMVQMERGMVVSPNNEEKAFVCPEIIEVDVAADDDVDETSKLLFGLATTVDRLDRLLPSLLYTYGNTKAGLIVLVPESDDDLEKQETYFRNRGLDLTLKASPLDFTARYFGMVEAFSEHIRKHRPHTTWVGFSDDDTFFLSLPTIAKELKLFDEKKKHYIGSLSEASWQVDTFGHIAFGGAGVFVSKPLLDVLMKYYDECQSWGEQPGDQKLGQCIQRFGDTPLTLWPSLYQMDMTDPVDGVYESGRKIESMHHWNSWYTKDVVKMTTVAAAAGRKSVLRRWVFDQEETINSATGESVRHFWVMTNGYSLVKYTYDSTVADDAINFDAVEKTWPEDPRGFEDRLGPLRPAEDEGVTKDRWLLHDAYVVGDNVHQFYVREEDEGHSVIEIVWLGPKGGGGGGISDHYIQGTYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNU3</accession>
    <name>A0A1Q5UNU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNU3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="16831" checksum="090B704A2D84CA56" modified="2017-04-12" version="1">MAAPREFSLTFETTPPAAVCPGLPFTVPVIVAVRPIGTPSHTVQLVASASLRDEAGTSAATGLGGSLTAMVRSRTEPSMSGYAKFAGLTISRPGKYRIRVMLSTSSVNGVMTKECVDSGVIHVHAAAPAAQRPTPTTVAKLQRLTAENLDISVADIAKWQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPB5</accession>
    <name>A0A1Q5UPB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_14085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPB5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="8603" checksum="B505985D75DFDA21" modified="2017-04-12" version="1">MDEKAFTLHHPVGSARMGPSPATSVVDLDCRVHGVKGLRIMDASIFPEQASGHPPAPVAAMAAKLSAIIIDENTASTRVGANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPI2</accession>
    <name>A0A1Q5UPI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metal resistance protein YCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_14164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UPI2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="892"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="937"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="260"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="611"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="898"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1454" mass="160290" checksum="83636C5CADFE8400" modified="2017-04-12" version="1">MRVDAGSCRGGFDFSLLFEEAILSLLPIALISILVPLRVWQLSQKRRKVVGSWLLPIKLAAWVFFVGLGIAQTVLWALPTADKSKASIATNAVLTVGALMLCTLSYAEHTRSVRPSFILNTYLLCSLLFDIARARTLWLRAADGFNEVIAIVTTVAVGCKLLLGILEAIEKRHILKTEFAGYPPEATAGFYNRSLFWWLNPLFKNGFSNILSVEDLFVLDKELSSERLLAMFEERWSKVKSKSPNTLQFESFKAAKSPLLAAVPARACVVAFNFCQPLLLARSLSFFDEPLNNATNNVGYGLIGAYVLVYTGLAVSMGQYQHNTYRGITMVRGILVTMLYKKASSLNLNEADPASSLTLMSADVERITQGWQTMHEIWANSAEIGLAIYLLERQLGISCIVPVCVALVALVGSLIGMSFVVSRQAKWLEAIERRISSTSGMLGSIKGVKMLGLQDSFMKFVHGLRIDELEISKKFRTLLVYNMGFAWLTRIFAPIFTFAVYVAISDSTLNVSRVFTSLSLFSLLSDPLLTLVMALMSFAGSVGSFARIQEFLDKEDHSDQRRNTPQIPSLEDLGDAKLLSKSGDLDLVSSNSGSVESLKRGSTSSFSSNAAIIQNATFGWDAEKEAILKDINLTLPRGSFTILIGPSGCGKSTLLKALLGEIRCKEGKVELTSSSVAFCDQTPWHMNGTIKDSIVSMSEYDPKWYSSVIQACALEEDLSQFPRGDRSVIGSKGVALSGGQSQRIALARAVYARRKIIILDDALSGLDAMTESHIFHHLFGNMGLLREIGTSVIVASSSVKRLPYADHIVVLDKTGRISEQGSFSALNKSGGYVSSFDLGAPDWDYKPKRFSASPSYSTVDSVEKEKEAIIPEPEHRDSGGDLSIYTYYIDAIGWLPAFVFMVAMAIFVFCISFPSIWLKWWANSDTAEPKQHIGFYLGIYVMLGCVAMIALIVGCWQMIITMVPKSGESFHRKLLKTVLSAPMLFFSTTDSGNILNRFSQDLQLIDMELPIAAINTVATFFLCLAQMALIGVGSKYAAISFPFVLGLLFLIQKMYLRTSRQLRYLDLEAKAPLYSHFTDCLQGLVTLRAFGWQHGMEMKNIELLDYSQRPFYFMFAIQRWLTLSLDLVVAGIAVLLIVLVVVLRGTSLGAGSVGVALLNVIQFSQSIKLMVTFWTNLETHIGSIMRVKEFTQNVDSEDQPGEDGDIPPDWPSNGAVSFHSVSAAYRPSEPVLNDVSLSVAAGEKVGICGRTGSGKTSMIMSLFRMIELTSGIITVDGVDITSLPRREIRSRINGVSQDSLLFKGSVRLNADPTGSRTDRDIRNALKSVQLLPVILEKGDLDSDMDEIYLSHGQKQLFCLARALLRQGNILILDEATSNIDTKTDDIMQRVIREKFCNHTIIAVAHKLDTILDYDRVVVLDAGRIVETGEPYALLTDPKSHFGRLYASSITTEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPK0</accession>
    <name>A0A1Q5UPK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPK0"/>
    <dbReference type="OrthoDB" id="4342229at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012999429" evidence="2">
        <location>
            <begin position="27"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="20619" checksum="700084868EC3BD23" modified="2017-04-12" version="1">MSLPSLRPSWSIIGVMALLAISTVYAHPIQESTMEEQARPMPVVLPRDPRLIPDTEHYLSEVFDLLGVTEPKSTESTPTETPSETPSETPSETPSATSVPSPIVKAEHGQPINVDATPVVSGSGVTYSATIKHGNQKPIENIQIGSGYHGGKKLAASDLPIIFAAVETEIASRWRDVIDSSDELGLDDEFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQK5</accession>
    <name>A0A1Q5UQK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000070">
        <property type="protein sequence ID" value="OKP14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7617" checksum="358EA7841BB995A9" modified="2017-04-12" version="1">MLGVGSVHWVGRVALSREGRIRLNLDRLGQRIVAAMEEAKPYVGLHSPFGDTLVVKFVACTFSDEFKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQM0</accession>
    <name>A0A1Q5UQM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQM0"/>
    <dbReference type="OrthoDB" id="4355518at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7931" checksum="E6EC71BE5FE77736" modified="2017-04-12" version="1">MCFGFGGFSSVKPKPPRREKYGNNEEKYLRDYVRYEIKYEEYMNKDNRRRRMVDANAGAVGGISVATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URH2</accession>
    <name>A0A1Q5URH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein phosphatase PP2A catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URH2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="7052" checksum="CF06E325B69A6232" modified="2017-04-12" version="1">MDNNMEIDTARSPEPHNLSPTSDPGSIPTLDGWIESLMTCKQLAEEDVRRLCDRVGFFAERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URP6</accession>
    <name>A0A1Q5URP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Williams-Beuren syndrome chromosomal region 27 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URP6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URP6"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF80">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="23317" checksum="F9F74B745329661B" modified="2017-04-12" version="1">MTASATQLYLRQARDTKSVEDCMTIYDKWAATYNDEVGDEAQSYVAPVLVAQAAIKYKSSKSAADSVILDAGCGTGLVGQALAMGGAKAIDGIDLSAPMLGVARDTGVYRNLAQADMTRPLEQEDETYDTVVCVGTFTLGHVGPDPALRELIRVTRTNGIVVATILDEIWIPHGFKAEVEKLQAEGLVRVVSEDLIDYVKGHGDKAVLLILEKVNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMG6</accession>
    <name>A0A1Q5SMG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc finger CCCH domain-containing protein 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMG6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="320"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="450"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="668" mass="72181" checksum="EE48288832F058F3" modified="2017-04-12" version="1">MGHSTVWLSMGKPTTVGSVVLKRLATRKGLTLRRFSSRHVSTANKYPQPGYSIHPSTSTYPPGHYEPPSPLNMSNMAYSLPNHNRQSPSSPFEGQHLIHQYPSAHPQGLVYPIQSMGHYPGPNSGGNVPYAVPYAPGFVPYSMQHPGAGQHVAGHYPQYVNNPTMQNMGPGQAPGYGAGYYHPGYAPSSRHGSQSGPVQMRHSGSQSRQGSLSQGTSTGHTKKDTDKRGLDGEYDVSKTIVDGSNPMKLAPASSISPGTWEPMYSKRAVNKPRGRRRLQANTLTDVPCFLPSDSALLSQPVQTTLSTPRGPPRKPKQSGHALWVGNLPPGASVVDLKDHFSQDATTNIESVFLISKSNCAFVNYKSAAACAAALARFHDSRFQGIRLVCRLRKGFTAPGSGLGLGVAGPGSRSRPEETRDPPHPGVEVGSLSETPSPGQLADGEGSRTLDRYFIVKSLTVEDLELSKQSGIWATQTHNETNLNRAFENTDHVYLIFSANKSGEYFGYARMLSPINDDEELALEMPPRPEPLAGTTDELEVTTTAATSTAPKGRIIDDSARGTIFWEVESSEDEHDNSNGEKSVDGTGAGAGPGPPISAPGSITVDDEEAQSFGKPFRIQWLSTERVPFHRTRGLRNPWNANREVKIARDGTEIEPTVGRKLIALFHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMK5</accession>
    <name>A0A1Q5SMK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="20310" checksum="0287761524CBFF8C" modified="2017-04-12" version="1">MAADWQKTADGIESHFQNNYLAYFVLVNALLEAMLSGSRVVLMTTSIRREAPAPRWEDINFAVKLMKADTTTNVQTYLSPEDVASWLQRKKEAGEDLPILLQQAPKSLSQASATIIRGLLDPMLAVEQISNVSLMLSEQSGAFLDNCEVLTLPYLDFPVGEESATALWKQSEVYVEAAGLTQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMV9</accession>
    <name>A0A1Q5SMV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J-type co-chaperone JAC1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMV9"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.20:FF:000006">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="98"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="284" mass="31250" checksum="50900789A0F4F3F0" modified="2017-04-12" version="1">MALHAPRLARHLCRSATPRKIITSTRQGLINSSQRDACTLCQSRTQINRSSTFGLGPKSIYKPTNTPTRRAASTATSSAQTPTETTEPPITGAPDITNHYTIFPKTLPAGPPPSSPFEISISDLRREFLQLQGTVHPDKYPSGAAKQQAEALSARINEAYRTLSDPLQRAQYLLREWHGIDVTAEDASTKHALDANTLMEVMEVQETIEEVGASPEAEAEIDALKDENEVRIRDCVGVLAGAFDRGDIEGARRECVKLRFWYSVGEGLREWEPGSTEIRLVHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNK4</accession>
    <name>A0A1Q5SNK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannan endo-1,6-alpha-mannosidase DFG5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34636" checksum="8151BE4007A61384" modified="2017-04-12" version="1">MTTVANLAKVDPSVMEAALYVFNNTYNLAPASNPHPGPEVKTVFQRRDLLSRAGGSGNASKWLDSAYDDDGWWALAWIAAYDVTGSDDYLELAEGIFAALTAAWGTNCGGGGLPWNPTSTYVNAITNELFLSVAAHLANRSLSKRDEYISWAQRQWDWFSAQGFMGENDTINDGLLDNCQNNGQNVWSYNQGVVLGGLVELNKAAPDATLLESANAIAQAAIETLANANMIIHDSCEPNNCAPDATQFKGIFIRNLSMLQKVSPNHIYKQVIDSCARSIWANDRNSQNQMGVDWAGPFQGPADMSTHSSAMDALVAAIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNM7</accession>
    <name>A0A1Q5SNM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNM7"/>
    <dbReference type="OrthoDB" id="10506291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="22344" checksum="D3EAD1A6C5F9B283" modified="2017-04-12" version="1">MLNLSLEVHRALLFAVSRADAAVVDIPFGKGLVKNSSRVNDPYSQAGIRSMLGSVGSPNGELDAVTAMMVSLLRHGIKMDSGNLSACSEVFDKEVQLVKQSPLGPGTYLQLLLGRGADPFSDGGPFEVESLLEFVIKQGAKQEMKLLLKGLDEHSISSEELEEIVTEVESQVKRKDKQNILPLLRRACCRKKHREMMPIPWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRF5</accession>
    <name>A0A1Q5SRF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRF5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRF5"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="713" mass="76387" checksum="0EF65E8E9F183CCC" modified="2017-04-12" version="1">MALHPADDDEQLFTRAMTSYREAFLVRHAHLPEPQRHQLWTQQLTRFIPAIENNPVPPQVLPRTGGHSGTSGKRTRQDATPRTLPTADAASASSASTGFGSGSGPPQAKRRATTPDLPMAADLRRTISQTSSAETYRKGASLSGQGSYRHSPVKGPVGGREAMGLGMVRSQSQQIPVSHWHPPAGPVMGKRQSFGPTRTQQQPQQPLHLDHVDEMVNEYSPSEFAKHLDDCNINQAPFYGSGPGVASATPIPNTTSALTLGLANLGSNGLAPLPNPHSGQPSPMADVSPAAAVEMTRSGTTDTIIGGFNNFGFDQAASHADLEPAYPIPPEWVPTSTSGLPYQESFPSSLYPDLDPNASFPFSYPSSFSTSAPSATPFRPQHVPTSMNPTTPVTPLSTPGAVDMKPSISTESNSSATAAPSRAARRTQEQIAHGARPIAPKRESQDKAHLQPDPSDPNRMIRISSADGTTKEVAAIPKASVQRPPKAKTYCRLCNDQPDGFHGEHELRRHIDRVHAQVRKVWVCVDISPDKTFLANCKACRNGKKYGANYNAAAHLRRTHFHPCQRGRGGRGKDSEKRGGKGGGNQPPMEVLKLWMRETIERADEHSVDTFGADGLEECAGSLPSDSKGSVPPPGPGDASGPMSMGMGVGMSMSMSMGSSYGMDPTPMHGHGHGHEYEGFPGMSASFDLDATLETPFYVDSQQIPAEMETYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRN2</accession>
    <name>A0A1Q5SRN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13371</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="239" mass="26284" checksum="220C1275D2C9B1F1" modified="2017-04-12" version="1">MNPQTQSIVNHQLVDPCQGCVLLAKRCWLWKLCPSIANEIPIQTLENTVQIVEDLNKTRWGQGLSAAYFPEENVIPFSKIQYFGGPVYCLALLGFKVALLTSYLRIAGVVKLYRKVILAAIVVCVINQLVFAVIISVSCIPVIVSCIPTYGPLFKAFASTVNSYRGNNTSRSYQLGSVHPTSKSATSRRRSNFELISESEGAQITVTTAVTVSAGERTNYRKQSHGGDSEEHILFPGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWI6</accession>
    <name>A0A1Q5SWI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_12807</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWI6"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO92245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="470" mass="54354" checksum="27C0984D6A61DF98" modified="2017-04-12" version="1">MGFIGNAIYFAFHPIQLRSIIQWKVWHNPPHERNEKNDTETQKICYKFLDQTSRSFSAVIKELHPELLLPVTVFYLVLRGLDTIEDDTSIPLETKEPLLRNFKDFLTQDGWNFTGNRPEEKDRELLVQFQSIIVEFKNMKPAYQAIVKDITDKMGNGMADYCVKAATEDASVKTVEEYDLYCYYVAGLVGEGLTRLFVEAEFGNPALLKRPELQKSMGLFLQKTNIIRDIREDFDDERRFWPKEIWSKHVDNFEDLFKPEHKEAALNCNSEMILNALEHVEECLFYLAGLREQSVFNFCAIPQSMAIATLELCFRNYAVFERNVKITKGDACELMVQSTQNLNVLCETFRRLTRAVHKKNTPKDPNFLKISIVCGKIEKFIETIFPTQKAEDAQRRVKGELSRAELEKRKAEADSKSDVFFLMAIMGVIIFLVAGVMMVAAWFLGARFDLAWQEIRSGNFRPPAITQKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ29</accession>
    <name>A0A1Q5SZ29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAL effector protein Brg11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ29"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="155" mass="16349" checksum="E6BD92C7363DD50E" modified="2017-04-12" version="1">MEVTSRVVVAAAANEECGEAAMKVLLDGQGTDIQITDEVVIAAAGNKESAEAVMKLLLDRRGTDIQITDEVVVAAAANEQSAEAVMKLLLDRRGTDIQITDEIMVAAAGNKESAEAVIKLLLDRRGTDIQITDEVVVAAAGNEESAEAVMRLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZC8</accession>
    <name>A0A1Q5SZC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM8</name>
        <name evidence="12" type="ORF">PENSUB_12407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZC8"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO93344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11059" checksum="260DC86634931EF1" modified="2017-04-12" version="1">MSLPLMSLINKKVLILTVDGRTLLGTLLSTDQLTNIVLTNTVERIIRTPDDDEPSAQVEHGLYLIRGDNVVVCGEVDEKIDADIDWSKVKGQVIRDTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZE4</accession>
    <name>A0A1Q5SZE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SZE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DBL homology" evidence="3">
        <location>
            <begin position="678"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="898"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="1428"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1624"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1634"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO93256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1820" mass="199433" checksum="95B303D52562083D" modified="2017-04-12" version="1">MTGISPAHPYYPLGANIIDYSPNQSSVIELLVTAGGGCAALLGLTFTAASYVRPTLRMADRIAILWFVLSGTLHCFFEGYFMINHDHMASAQDLFGQLWKEYALSDSRYMTSDTLVLCMETMTVTSMPTPATPTRPSNRGGSAKSTPSKPLDIGQPLGIHDTNTVRSRVRQWQQQGGGVITINDGTYDEDDEENPPKPKPKVAKLKVDQLEKSAKEKEKEKEKEKVPAVRKRSHSTPRKRVISDEHWRKNRSTTNTPSRNLPAPRRINEYTTNGDAGSPRAKRDVKKDVLDKTRDPPKFKAYRIKDVSESPTRDFKSSSVQKDAESVADSDLDTDLPPQSTIAPEIPEGQRRKSPPPEDIDWAKSEADFSELSRRRARGPQKPPKGGIFAHMLDESRKMFKLPEPEPPRPTPPPAGNRGAKIEAWLSETPDPFVDNRNPKSDMPGPLDIKSARARRSQRMVDEIAASIPISEISQESEPRPKSSGSRPKSSHSRHSKEQDDAKTPEKSRKIPEADMEKVEKPLALRIRHDKEKLGDNPYEDSLAPSESDFQPFSDGGSEVSGNNAPVPVGRKKPFPSTGYHRLSTIASVETLSTLPEGSTISEKATAKRPTPETLEEAEEAAEEKDQFDPDSLPVVASQLQRRLTTHKDLMSVLSGPVSRSGSTRSRRSIRSNKSRLANATIPDLLAELSADEAKYMRELKTLVGGVIPVLLTCVLSRSDSAIAAGLFRPSLDPKDDLNFSKPIVNMGVAIERLKTLHKRIPQDDADDLLTWAQGAQRVYREYLKAWRLGFKDVIVNLAPLEEGEDDGNAETKSLDEGMERDEHGDVIGSNGEKVDVAYLLKRPLVRLKYLAKSFKGINHLQPSAKAEEISTAYASLVTDARKRARDERARLEDESAASIDPTRARDPMTLGLSSNVVVDQTRRVRARDFFNLSLYHSSGQLVDCRAELLYRDNTSSNGPGGDLLICEIDHSDRWLLFPPMDLRCVSARNGDSKGEIVVMLRSAPGEEKYWQELISLRIDEVEIGLEWVQLLGQDPVPPTLCRSQSFISRAKQHKARKSSNSDSPPRAHPSDVDIPIGEKATTKRRSLTPKEHYSEPSTVSSSVTENKSSILSTATRETEYTTGGSEVSSKQAVRPGLPLLPSTLSPEKSPGGLKRSKAKRHSRHADSPVSETASPMTVFSDLPVEPSTPTPAPGRFYGGADSAKDVASPKEKSAKKASQIPRPKESPERESPRVSLTPSPYLPIIPKIRSTSSQTHLSSPSTVEPEEEDYPPLESLPEQEPLETPTKSNRRKSRRKSKHEEAPPPPPPHRSPSSSSNKLSNSPVLTPSGVKLKRRGSSPLKHEYEPSTASDYSETDSDASTVRHYAYSSSEYSRSVTDSDSYSSASEEEDVPELPKPRAIQSTTSDASSLSPSNSASQGGYRTVPLQPTKSTKAVAFIFAWSDKGSWDSLVPDECSIIVSPGLIEAFKMGSDSSSSRPLISMELTPLVPIRRGTAIDISVRSPPTDRSKITSSNNIMFRSRSPDECDALYSLINQARINNPTYIALQNARGPVYDNHMPTFEEPNTKSGNSWFGFPRRRKSYRASDSPRSLAEGSESSVGTMSSAFSALKRFGGGSKMFNISRSTVTSRSGREGSIYSGSGGSSDPSPSSGIGRIAAAIKGADGIGLSNAKIRLYLRETASKWRDMGAARLTIMPAPPKNPPSRPGTAVSARSEGSRDDSTSPPSSGAATPRRDVEPEKRIIIRGKTRGEVLLDVCLPESSFERVARTGIAVSVHEENEGGVIAKQGGVGTSTQRIYMIQLKSEAEAAYTFGLVGKLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0I4</accession>
    <name>A0A1Q5T0I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Decarboxylase DEC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0I4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0I4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="29191" checksum="5D50D880D787FBA6" modified="2017-04-12" version="1">MVLQCSLTFGESNCPLSGSKMPFGSLPVSNTPIPQYAPPYPVDGSDYTSEAVLTVTYQTSLQCVRHLVPDMLELEDEPQVSVMVLQHSMTSFGPYNEYVHLVEVKYNGDTFDYFLSLILDNDSPICCGREQFGFPKKLGNVALSLKTGSAVVHGYVERPAGQKIVEVGFQPEQKLKGTVERTIQGLNLRVIPSVVSNQSPSVKELVPVDISIEASEVWQGSGSVCFPEPSRFDPMHEVKVVRYGMATLSRNASLAIRRPTKVFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T109</accession>
    <name>A0A1Q5T109_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethlysulfonioproprionate lyase DddW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T109"/>
    <dbReference type="OrthoDB" id="445803at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF6">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="3">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="163" mass="17816" checksum="95F8651FD57D24FB" modified="2017-04-12" version="1">MDPHLYLTNMPTPQPPSTPRRISIPKTKATIIPSTYTTTKPPESFPTTANGTLTWHTLISQPQTPTSDLSAGIAVCPPRTGHLCPHRHVQAEIYHILEGVGEVTIDGVVNKVEAGSTVFIPGDAEHGVVNTGLEDLRWFYVFPTGAFGDVVYRFEEGKRLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2H5</accession>
    <name>A0A1Q5T2H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-arabinose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2H5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2H5"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="51909" checksum="79F7AFF82AD8A7D7" modified="2017-04-12" version="1">MRPSTPLSADLPPLIMGTATFNSQYNADPFALPTTELVHRALSRGVRAFDTSPYYGPAEELLGRALATDFVQTNFPRESYRLLTKVGRIAGESFDYSPTWIRHSVRRSLRRLHTTYLDVVYCHDVEFVSPEEVLVAIRELRRLRDEEGLLRYVGISGYPVDVLSSLAEMILRETGEPLDIVMSYANYTLQNTRLRSLALPRLLAAGVDVVPNASPLGMGLLRRDGVPIGSMGDFHPAPDGLRTAIHAAANRTAQSGEKLEVVAIRFALESWLRAGAKAGALGAPLARSADADPGFLSVANMGTGRRLGVSVMGVSNIAELDETLRVWHSILDGLESWDEDDEESEFDVENHLLETGPSTADVDKPQTDGAIAPSAILTPSEGLITDRAWSHTRRTKILHLAKEVRDVLGAEWVDYVWASPPPDFKNTLSDEHLAGMRVFEDEEAAGKMLASPAEFVRDERMLTPPLDADAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T602</accession>
    <name>A0A1Q5T602_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11178</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T602"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF57">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="39784" checksum="81852929255E7D3A" modified="2017-04-12" version="1">MATLVSKQITVIASFAVLNLLALIAMGLRFYSMKVVHRKIKAHDALCIVSLVMLIAYSIVLLIGTIAGGIGLHIGQLSMPEMEPKMETGLKAFFSSQFFWAISIASFRLAILDFYVQAFPTKVFRMFAYGAMTVVGLFFIGSITTTLAMCRPIVSNWDQNIKGKCGDEGTAELAAAAFNMALDVGIVVLPVPVIWGLHMSKQKKAAVVATFGLSLGISAINLARIIQVLRCSLHDFTYCTADAAILTVAEMAVGIIVSCVPMLGPVIFPERRRRFDKRYIYQPNDSSYGSSRKHGRQHSDSQGSTEMALGPNWEKRENTQNMQYTQIYNKVLPPTPVHVRQGEIAVWREFEVQSDASNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T631</accession>
    <name>A0A1Q5T631_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_11209</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T631"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T631"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="202"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO95697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="404" mass="43201" checksum="DECFD19093DB46C3" modified="2017-04-12" version="1">MATPSSQPVYRATTTAPVNIAVIKYWGKRDTTLNLPTNSSLSVTLSQRSLRTLTTASASAIYPAEDTLNLNGKPQEIQSSKRTLACLSNLRALRKSLEDADASLPKLSALPLRIVSENNFPTAAGLASSAAGFAALVRAVANLYQLPQSPRELSRIARQGSGSACRSLMGGYVAWRTGEQADGSDSLAEEVAPASHWPEMRALILVVSAEKKDVPSTEGMQTTVATSDLFATRAQNVVPERMDAIEVAIRDRDFPKFAEITMRDSNTFHATCLDSWPPIFYMNDVSRAAVRLVHDINRAVGRTVAAYTFDAGPNAVIYYEEKDSELVAGTVKAILGASASGWEGPFYEGLANLTAPGVSLDNIDSRVLDVLKGGVSRVILTGVGEGPVTVEDHLVTETGEIVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T663</accession>
    <name>A0A1Q5T663_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T663"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="216" mass="23552" checksum="040D000530C745B2" modified="2017-04-12" version="1">MGALKPQTLEHPSDYDRQGSKHDSGSSAGGVEGLKPGGHVTAALSFVGSSSSPPFSNSLFGDSGSGGGHDFPTFPETLSRLCIIIIINFKVQNCKTRVSSQDQRWRDANDAGSEPSLVLICSLRALQAPSAFREGDFSKVGKNQVDGRRLCKAGRPSCCSRLVVTDASGAYRYYLFVTVITYVLTWVKWMDHYAREKRKMPWGKLSNGNRYHLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6V8</accession>
    <name>A0A1Q5T6V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family protein MCP2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6V8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6V8"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="221"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="630" mass="69930" checksum="04D0E8ACCA70D54E" modified="2017-04-12" version="1">MSAALRVPLRACANPATVIGQSFKPSISTSISIPAGASFHTHSKSALHTSPVTCANTVKSWGPPQNCTNSISATAKRSFASRTSSLLSAEASSLKSNAAEVKSSPALRNYAKYLVILGLLGAGAFAFSDNVQHIYGAAQRSGRVVGTLAVCINDYRVTLNQAAVASPEDYDALIRACHKRCAERTLRVLEKNGSIFIKLGQHLSSMGYLLPIEWTSTFIPLQDKCPVSSIESIEQMFVTDTGQTIDELFSSFEPTPIGAASLAQVHIATLKETGQKVAVKVQHPALAEWVPLDLSLTRFTFSMLKRFFPEYDLEWLSREMDLSLPVELDFRMEAQNATAASEYFKKHSDAPLVIPEVMWSQKRILVMEFIAGRRPDDLAFLDANNIDRDEVSAAFAHIFNEMIFGDEAPLHCDPHGGNIAIRPNPTRSHPNFDIILYDHGLYRNIDRDLRRNYAKLWLAVIDADVPRMREYAYKVAGVTDEQFPLFASAITGRDYSVLTKKNVASARTAEEKKEVTSALGEGMLQQLVVLLGQVPRIILLILKTNDLTRSLDENLHTRQGPMRTFLILARYATRTVFEEQMESIRESGGVFMNFFQFLSAWAGFLRVEVRLSVYETVLSLKSRFGLQTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T831</accession>
    <name>A0A1Q5T831_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GTPase-activating protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T831"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T831"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="73"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="865" mass="93708" checksum="B685CCB650231279" modified="2017-04-12" version="1">MVTGKSHPGGEPVQLPATSPDPTGSNSPPSKRDLASWWRQFKRNTRKDEVKEPTRGIFGVPLNVSIKYANVAISLTGEHGKSHIYGYVPIVVAKCGVFLKDRATDVEGIFRLNGSAKRIKDLQEIFDSPERYGKGLDWSGYTVHDAANVLRRYLNQLPEPIVPLEFYERFREPLRVYQRQVQAEKEHVETEKFDHAKAVETYQRLIVELPPLNKQLLLYILDLLAVFASKSDQNRMTSANLSAIFQPGMLSHPQHDMSPEEYKLSQDVLIFLIENQDHFLVGMSGTTPDEQQVKEVEAGLQPAASSKDVEGGIVSRPSTTSNIRRSVSNASGNDGHRKIDSVRRNVSVSSRNSRGSRHSNNAPSPGTPTSTSGGGVHRSNTLPSKMGPVVASARFVRAGETGSANPSGLSVSHHSSRSASRAPSLREETEPQKPSTAPSGTPIRSVFVHTSTHGPIPVATAEQLNIVERTPPQENNETHNPPQSPPPATLPPQNLQLQGLAGPVSPPPQVVTPTRERKLSNFFTKSPPPEGEARQPNRLRKKRIPGSASISAQSSTNSLDPHWDSSLEPNRDRKSFDGAVGDTTPKPPNTATLSNRDAHSESTPTLGDSSSHPNTDNSLRPHQSRTPSMNSRSSFTDHSDLEQPEDGSRSERRDNRRSWRFHRSSKRSSEQIGLGLASPPLVASDSGAAQSTTSFGSGSHQSNDPASQPLSLDAGIQGNSIPNAEPEKRSLFGKFKAKMAQVVKDDRERAKSPNQSDEPSATSQPLSPTIPNHANGKPPADVFAEHPKEEPLRSPASPLPGAGLPPAIPEEPNSPEAPSAAAEEFKKQLEPEPATTAETTAVPTETPAVAEPSKETTPTDKETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T836</accession>
    <name>A0A1Q5T836_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T836"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T836"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="244" mass="26587" checksum="1716D922FF42019E" modified="2017-04-12" version="1">MTLPTIVFVPGAWHTCDYYKPVISILTNKGFPTATVNLPSVGGISSMTDDAIAIHKVTSKLAEDGQRIILVMHSYGGIPGTESAKDLSWEIRQANGEPGGIIALVYVSAYLIKEGMSVMSVAGDAEWPSFLTKQDGQILYDKPTAIEKFYHDFPQNESPTAWAEKMKPQSEASFSGALSYAAHKDIPAVYLLCEQDRSLPIGLQELFVTYAEGKITTRRCKSGHSPMVTMPDEVVETILLAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9J5</accession>
    <name>A0A1Q5T9J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UPF0695 membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10395</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9J5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9J5"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO96841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="486" mass="52048" checksum="E63DF619BEDF783E" modified="2017-04-12" version="1">MAPPTESGLSRPSAGFDPDCDPQLTETMAPQPVERVPSQRSQWYTSEQPSSQNETATPTHPSRTPEDLEKDADPALTETIAPQPVSLVPSQRQRWYSPEPEAVAPGPAPVSAPEPTPAPAGKAPSEPLSKHATQLYTISYLVFFSLLGTLARLGLQALTFYTGAPVVTGVLWANVTGSLVMGFLIEDKNIFQQEWGATTPPPKDAHEAAQHAKKHKAVKKTIPLYIGLTTGFCGCCTSFSSFMRDVFLALANALPDPSLPAGTGIAPRNGGYSFMALIAVLLLTVSLSLSALIFGAHLALALVRVMPTMPFAFTRRVVDRVMVFLAWGCWLGAVFLAIWPPDRHGDDHWRGRAVFALVFAPLGCLGRFYISMLLNSRLPSFPLGTFAVNMLGTLVEGLCYDLQHVSGLGAVVPAAWTGCQVLQGVMDGFCGSLTTISTWVAELNGVAKRRHAYVYGVVSVAGGLGLLVVIMGSLLWTRGFDEPVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAY0</accession>
    <name>A0A1Q5TAY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8470" checksum="AE4D5413A187D91E" modified="2017-04-12" version="1">MNTPNEQDFSYIGGQFPAINIKGADLELELPNDHPLRADLLPGHLPADGSSSSSSSIIAYLNEPEAAQPWSPLRASNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB12</accession>
    <name>A0A1Q5TB12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB12"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB12"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF39">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="275" mass="30882" checksum="0358A00C76B69915" modified="2017-04-12" version="1">MSQPFSTLPATARIPPKPFTVAIPKEKLADMETLIRLSKLAPDTYENSQSDMRYGVTTSWLVSMRDQWLKSYNWKTTEDRINSFPQWTAEVERLNIHFVGLFSEKPDAIPILLIHGWPGSFLEFLPILDMFRQEYTPSTLPYHLIVPSLPGYTFSSGPPLDRNFTTSDIARVLDQLMKDLGFESGYVAQGGDIGSRVARSLAVDHESCKAVHLNVCFMGRPEGILDDSLEASERDGIKRMEEFRMMGSGYAIEHGTRPSTIGHVLASNPVALLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB35</accession>
    <name>A0A1Q5TB35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB35"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF1">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="80"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="550" mass="60087" checksum="F6930B7702C62345" modified="2017-04-12" version="1">MATTISTPTYQERAAEKRANQLALIPPEWRLSPVPSVESHPDALAYIRNILTPAELALTEETDITVLLRKLASAELSSLELTRAFAKRAALAHQLTICCTEIFFEEAFATAKQVDEYLAKTGTTIGPLHGLPVSIKDLFSVKGVDTSIGWVGLTNNPAPSDKSVARTLRRLGAVLYVKTNLPQSMMMSDSYNHVFGQCVNPLNRNLISGGSSGGESSLLAARGSALGIGTDLGGSIRIPASLCGLYGLSPTPGRHPYERGSPGQDIIRSVAGPMSCSLATIERYMEALPCASPWELDQHTTPVPWRRSMASLKAKRLRIGFLVDDGVVRVQPPIARAIHEVVTALKAAGHEVFEWDPSSHGYAYQLWEKAILSDGGEGCRKKIEMTGEPLIEGMLVGTEKDILTTSETHQLHADKYLYESEYLDRWTTSGIDALIMPNTPWVGYKPWTWVKSSAYVGYTSIWNLLGYAALTVPATTVSMEKDVPDGEWLDHVPRNAGDRFNKEQYDIDLVDGMPVGVQVVGGRFGEEKCVSVAKAIEQAMRWRDAARSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB70</accession>
    <name>A0A1Q5TB70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB70"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="145"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO97447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="410" mass="46221" checksum="99756BC7A543AC15" modified="2017-04-12" version="1">MDEEERPRKLAKLEHDDEAIHDELGLAMTGALAAADEQPQTVAPTNDNTQPEQSEAPNADNAIPSNDSALPEGTAAEGAPPKMSKNQMRKLRKKEQWEAGREQRREKRRELMAKKKERRQRMVDEAREAGGEEAVKALRKSWETTRSRSRRSTLLPLSIVIDCGYDELMNYGERISLAGQLTRSYSENSRAMWRSHLVFSSFNKQLKERFDTVLAPYRNWKGIRIIPEDFVHASELLKEQMASPKGGKLVGPFAEKSDAKPEDGEVIYLSSDSENILTELKPYSTYIIGGLVDKNRHKAICYKSAVEKGIKTAKLPIGDYIQMASRQILTTNHVVDIMLKWLELGDWGEAFMKVLPPRKGGKLRDQPGNEAAEEATDDEPEEEQQTLEDIANEMEAEQAGGDDHEDEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBJ8</accession>
    <name>A0A1Q5TBJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBJ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="313" mass="34717" checksum="74302F250C8D49DE" modified="2017-04-12" version="1">MLVGVEGVGSFHRRPGREHFSAAAAVFDLAALSEENNCRGAGDLTYTSSSTWRSFASRPPRSSPVPKPQRRSAPSSSQYADLPKNLQPKAGGLGRLFSRVAHEGDVTLFQAHSQRSYYFSAYGLSAFCFAYAVYNSNAVFRDPVTVLPMWQQALFGGICVSMSVMGTLFLVRTGNMIRSIKAVHSQGQPRVRFQVRGLVPFRKYEFEVAPSQVHISKKLVVSPESVARFENDSRKLIGGSNEPKPSFFKAPVARLSHGVWRIFLSVRQIFTSEDFILIKIDGRKGTFRMDSNGAVDRDFLLLGNPVRMRGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBJ9</accession>
    <name>A0A1Q5TBJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000690">
        <property type="protein sequence ID" value="OKO97598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBJ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="813" mass="92300" checksum="CF535AAFC7D615AE" modified="2017-04-12" version="1">MPSPLCLILSDDESDTSSDLPEIFSDSASDSDSSTAPSVFDGSSDSDSESDDELEDELALEDEEEQLSPEYYLQEAEALDVSQLRQKRYSPKTQERLDETQDFWDRFCEGAKRDPVKCLTWISDTEETVRFLKALFSWRCDQRRGKDGRRTPGLKTKSSLDAFWKWWHLIYKAAVGHGLSKDIQVKIRDVLAVVATEKKLSLKKRPKATMFVEDVAEFARVILSTTEMTFPCGWYRIQLLLFCQLAAITGNRPGALLKLRFRDLKLTLIRDPNGGRPRLFIYLRPEFTKGFLGEKQSEAFPIPEIIFDPTLVLSPHVFLLGILFRIGAFKSLSTDSPVLDCPEKLYRLRVLHGLGEQELKLKDEIMDQHVFCQALREADGIRFAPEKPLTRGWLGYRMKRGGEITGFAEVAKPYCLRYGAAKAFNDSPDVSNELQNVMLQHASIDTFVRHYSVGIHVDAQAIVRGLPAEKQLMRFACSMSRSIDPRRPYRLEDSSCINDIPRVRALEDTKQARKRIRDVKMRTYEDAEAAFQGEFGDDPQSATLSKTARKRRKAQEKSLKKLRQKFDHADEQYDRAVKQLRNEKRRQKHRLIRENLERYKNEQPVIDSERQLSGKVVDEEVMGALQRTGYMTPQHMTLIDSILTMPGTTVTKEYERRIAAINAVIAVCDAEEGAPSRPGASQKRSVDAVDTPPASPLPKRQKSTPSDESDDRFSQAIASVCVKSREERPTICFICLGKAKLPESKRLQTYKNPGSLSRHFVNQHIKPFPNDMHCECNICGEKLLSKSGLLNHAQRVHGIVSCLPLPALGLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBU4</accession>
    <name>A0A1Q5TBU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBU4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBU4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="57901" checksum="41A234716907F9A6" modified="2017-04-12" version="1">MPSLELQPSSSRPVNQVEENPGSKADIDLVESAGAGRAATYEESVAARLPKAHRDYLLERHGTLELDPIPSMGPADPYNWPEWKKMVNLILVAFHACMATFTAAGIIPAYANIAEDLGVTMQQASYLTSLQIAILGGAPLFWKPLSNRFGRRPIFLLSLILSLVCNIGCAKSTTYASIAACRALVAFFISPASAIGSAIVMETTFKKDRARYMGVWTLMVTLGVPIGPFIFGFVTYRLNYTWIYWILAMINGGQFILYLFFGPETRWVGSGVDREVATWKTEYMSLRRIDPTPLTWYEFVRPLTMVRNPSIVIPACAYAMCFLWGNILATVEVPQLLQEKFDLNAEQLGLQFLGPIIGSLIGEQMGGALSDYWMKQRGRRMNRKPDPEFRLWLSYFGFALIIIGIVVFLVCTQESPSGHWNVSPIIGTAIGAVGNQLVTTVMITYAVDCFPQEAASVGVFITFVRQIWGFIGPFWFSPMFETVGVARSSAIGCALVFAVSVVPTAILQWRGALWRRNAEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC32</accession>
    <name>A0A1Q5TC32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC32"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="44"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="56963" checksum="7D7EE08429B481FB" modified="2017-04-12" version="1">MDTRETTKSDSAHLENVANLPDKLTVCVSSPWKCIAENPVVILFCLYGNLGALMYGFDNLVLSLALSMPGFEIQFGELSNGSYVIPAYWQSLWSAMSQVATMLGATTAGPVQDRFGRRASFLLGAIFSVAGVAVVYTASTPGVFLAGKIVNGLSLGICLTSGQTYISEVSPMQIRGIALSAFTFCMNLGYMIAASVALPRMSMVTPAAYKVLFAAAWVWPGVIILLLPFIPESPYFLVMRDELDKAQKSLARLGNNPSQVTPLLDQIVRVNEEEKARSAAAEGASFLECFRGINWRRTRIILICNGLSQVVGASFMSNGPYFLVSAGMSSAKIGMMTEIGIGFGLASSILTAYLMAKCGRRRLIMFGLSLSTVFYTVMGIAGCFPNSTTALWVIGVFLELTWWVYGPAIGPAMSIAGEVSAVRLRAKSMAVGFTFNYFFSTVWNVVMPYLYNPDEAHLGGKIGWIFSFLGLVTLAIIHFEVPETKGRSFEDLDEMFNEKVSTRGFRTYQCCLPQELRKLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC42</accession>
    <name>A0A1Q5TC42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC42"/>
    <dbReference type="OrthoDB" id="4364855at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="37636" checksum="A541F6D435B47EFC" modified="2017-04-12" version="1">MDDSMNLDYLKRDPRWSPSEEDASIISSEPTVTWGTDAIATPVTAEASHMAAGGTWAAEAASSQEGLLESLGGSPSASITPAWSTTTTERTSTIPISTSSSSAVSESTTTPTTPTSTLSTTSPETAMTLTGTVVSTTSAVVETTAPGAYSGGGDSIKNKLAIAIPIAVVGLLIILALLFFFIRRRRRRTAHPPYEMSGTETPGVSTAALMATTPRIIAPPEPAATNLHQLPVIGVTGSSTHEITPGSASARSDDDARTELGIAMAVPMDQRLSATEHDLREFSRPVSSVSHRVSAGPPSAGLASVRMPFETQSSDENDAVSIISGERGRTDHDRDFDDMSSVSSFDDDHSPVEAPGQNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC51</accession>
    <name>A0A1Q5TC51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC51"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="282"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="684" mass="77428" checksum="9B23668FF699DB0C" modified="2017-04-12" version="1">MVSATANVRVVIVSNGDIRYRYLMCLLWMELCHYDYERDKYHQSPCTHPIDSGPSASSSSTNTVLPTPQTSLVSEWASKDQSKISNFGYSSQSSHHTLALLRVTEQYTDHKHTSTGSYGTNYDTSRGIFQSDADRKYKELVRHLPSQPCIDVLIQTFFYGVNWQYDLIDEEHFREQLDAWGKVSYSALQAGCEKLAPEMRVFPALLFQVLAQALLFHPPQDERIKSLLTMAEMTFYDLGVEFSDVGAEILTLLGKRGITIGTVQAGLLRASFLKSSGKVIEAWHTLGATIRDAQEIGLHTGRLMSEQSSDLSENGVINARESYIGHKIWVVLHIWDIHMAVVLGRPIVTDLNLDNFTRTVTNDEKRRELFSHWQKDTDPPRAFDVILAGYNVAYRYFPQIHRLGQNGARAQDYTVVESIHTALKKNLELLPSWCQLEDPDTTFDQMPGCHWLPLAREGLSSLIHLVFLTLHRPYIFATAKSRTEALKAGIAILRAQERLFQRPELQSCKIFNPVYASFDALVLIAAICIAFCNQGLEQLTKCIQVLERGVKRLEAIGQFNPMARSAHAVAWNLYRQLQRRLTTFGTAGSSRDQFSNTDMASLNGHTDYLMGMSSELSFNNVSPSNPIQDLFYDHLSISQITRPDAPNNLPFDPLTVDRTDGWDFEGTFADTSFWSLMNEFNLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCK4</accession>
    <name>A0A1Q5TCK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide transporter PTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="622" mass="68019" checksum="E4F7CC1413097F0D" modified="2017-04-12" version="1">MSIVLRIYSSDCFVALSVNRTAEAKAPITETAVSHPSSGSIDTVADPALVVSGNEKSLETVDREASTDSSDDGYEFPTEEETETLRKVPGNLPLVAFALCLVEFAERASYYGAKTVFSNFVEFPLPKGGNGAGAPPRHTQETAGALGMGLQAASGLTLLFLFLAYVIPIFGGWWADVHVGRYKAIIVGVAICGVAHIIQVFGAIPSVLQRGASNSAPPFIIGMILLSFGAGIFKPNIAPTILDQNRQKKAYIKTLKSGERVIVDPESTTTRTMLIFYGFVNVGAFFMLATTYAEKYVGFWLSFLLAGIIYFLLPILLFAVYKKTYKAPPAGSSELSRALKISGAALRQNKFQVWRKDFWEAVKPANLREKGIVVDWTDSNVRDVARAVSACDIFWFYPIWNLNDGGIGSVSSNQGASMITNGAPNDVLNNFNALTIIFVVPLMTYVVYPALQRRNIRFGPISRITFGFFLATLAGLAGTLVQWRVYKLSPCGFYASTCDEVAPISIWWQLANTILSALSEIFANVTAYEVAYARSPEGMRGLVMAIFLFMNALSSAIGEILLPATKDPWLLWIWGAPTVALALQTVIFWFRFKHLNDEQYYVTSVENQESVGDVEKKPGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD83</accession>
    <name>A0A1Q5TD83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD83"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD83"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF15">
        <property type="entry name" value="PRNA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="772" mass="85881" checksum="B0E5D9D093A633AD" modified="2017-04-12" version="1">MDDSTPAPAQPPQQQPKRPRVAEENRKRAVRACDGCRRVKEKCEGGVPCRRCLRYRRQCIFTHIDPAEKSRSASVSLLERAASLSRHDIQEAERVRYMERILSYYVPNITFDIQSLRQAAEELKSKHRDSESDVLSMKADANDLEDLAIDEEDFTIKALPDNTTHFLVQIFFKYAQTNNFYVEEDWLQEKVNICYTNPSSLSSDDAGAVCALLMVLAVGTQFAHMESTTPVNRPPPTANTDQDHHFSEDEVGLTFYQFASKLLPDIIATASVRSVQACLLIGTYLLPLDTSGLCYTYFGLALKLAIQNGMHRRYHGEGLSARMIETRNRVFWTAYTIEKRISILHGRPASLADVDVDAPLPVDFPGIMPAAQQSNHTNMIALITLTLKLGEVSNEISSLRTCRKGQQQDCLERLLNIRKHLVEWWSTLPEETNCRDLNPAGPLFRSNVHLKLDYCLTRIFIGRPFLFSNIKGLYQTSTHAAALKGPSGMAKNRATLVTDCVEAALEIIDLCRLLRDETGLARASFTEFSSCRAALLVILAQGLTKRTERLGAALDQGISLIKIMSMGVGSARSAVSVIEALERAIRRLELWSESHQSQSNGGSIESAYDRFKNWEMLWKTGPVSPTTMAWKREAYANDSALQQAMGHHPPDPSVAESVMQGVPITPPVLPPNSAHGSHSALGGHEHEIMEGDIPGSSLSIPDNYSVSHQSLSQMPHFGFDHFVSNFPQELGEFTAIPCFEPDTHGNPSGLPVGTDLKTPGSTDSHWLQYMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDY7</accession>
    <name>A0A1Q5TDY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDY7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="26106" checksum="65ACECFA62DDA140" modified="2017-04-12" version="1">MADLRQTEEEMQTKSTHARLYPRHHSCKRFLPIAPRLSGSSGTAKDTPGTSSSARVSRSGSTSAASVSSFQTPVRGWQSSSRRTMVRGSVGKWPGSEGSGNEPCGSSYALLSTSSPIAGLSVSAGPSRAGSSQSISHSGPDTVILDPAMGGDIIDTIYSLIPSSSVTGASLVQNAPVITLLEGTNPFDFPLDLGQRHDNGTLEYLDDMDLTEGITAEVFHVEGWSNYMWSPETGFEQVNTGYLAVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE50</accession>
    <name>A0A1Q5TE50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE50"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="87"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="183"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="284"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="416" mass="45630" checksum="63DEB27EBC7BFC73" modified="2017-04-12" version="1">MVFIRSLSRQLRRPATQFILAGSKPALATSSFARAQVSGAISHTRTLTASANLQGKVLLVLYDGGEHAKQQPRLLGTTENELGIRKWLEDAGHTLVTTSDKEGEDSTFDKELVDAEVIITTPFHPGYLTAERLAKAKKLKLAITAGIGSDHVDLNAANKTNGGITVAEVTGSNVVSVAEHVVMTILVLVRNFVPAHDQIRNGDWDVAAVAKNEFDLEGKVVGTVAVGRIGERVLRRLKPFDCKELLYYDYQPLSPEVEKEIGCRRVDSLEEMLGQCDVVTINCPLHEKTRGLFNKDLIAKMKPGAWLVNTARGAIVVKEDVAEALKSGHLRGYGGDVWFPQPAPKDHPLRYAEYPWGGGNAMVPHMSGTSIDAQVRYAEGTKNILDSYFSGREDYRPQDLIVHKGDYATKAYGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEN1</accession>
    <name>A0A1Q5TEN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="10851" checksum="06B20A0C47C4A1D1" modified="2017-04-12" version="1">MSSTKDENDLNKDPAWFLINLIMHTEAKKLEKRYERIMASYGLNTTYLPKPGTQTACSAQAESSAAGPGSSPPRRKALKRKHAEVEESEGVPDSKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEU7</accession>
    <name>A0A1Q5TEU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cutinase transcription factor 1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEU7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="356"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="923" mass="101958" checksum="52CC147B8A021475" modified="2017-04-12" version="1">MSTTTESRTEPPAPNPTSPAPSATGSTGTSGITTCHSRKVRCDAASLGVPCTNCVAFSIECKIPTPKRKKNSSKAKDDSRYGDSPPPHNSASSLVDAAVAQFRPDNPDDPLNQDSSDRKTRESSSEDREDSSFGYRKDRMANSGMPITSLTESEAAQQASTDNAYAQFMKPKFARAPIKEAGRVAYLGESSNLSLLVQDRHGTTDVVHYPLPPNIRGSRARLTDLDNLEIDILHQRGAFLLPPKPLCDELVDAYFKWVAPIVPIINRSRFMRHYRDPKNPPSLLLLQAILLAGSRVCTNPQLMDANGSTTPAAMTFYKRAKALYDANYEDDRVTIVQALVLLGWYWEGPEDVTKNVFYWTRVAMVVAQGSGMHRSVETSQLNKPDKRLWKRIWWTLFTRDRSVAVALGRPIGINTDDSDVEMVTEDDFIEDELDIPAEYPPEPVHVQFFLQYVKLCEIMGLVLSQQYSVASKSRRMNAMDLTHSDMALADWLQNCPKEVCWQRSRHHFWAALLHSNYYTTLCLLHRAHMPPASSAPNSYRVEEMAYPSRTIAFQAAGMMTSIIEGLQAHNEIRYTPAFIVYSLFSALIMHVYQMRSSVPSIVATCQERINVCMSALKDVSKVWLVAKMVNTLFESILGNKVLEERLQKAAGKRHQRRPHDSAAPAKATRPDPPKRKFDDMDLGLPNGGPTPPVSYERSRPQTPAVTPSRELNQPPLGHVSPNHRQEPIAGPSRGNTRPTTPFNAQFSLPATPPDFFLVTRNSPNLSPSLWENFQPDQLFPDGTAIFPELTSPPPPATVDPQLHIPSQLHAPNMGQRPMMGTPQQPVPGRSMSVSQGSPQMMSGVPGAMAMGPGGPQQMFGMEGQPWPMQGLDGTMTGAALDAASQDDNWSSSSRSGPTAPTTLNVEDWFQFFGINGGFGDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF53</accession>
    <name>A0A1Q5TF53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF53"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF53"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="247"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="493" mass="53641" checksum="79F1DFC5406C0220" modified="2017-04-12" version="1">MHSLRSRKPQKQGRKRTSSTVSNATTVTQAGPGQSPKITNKPSSPNDQFNASKQALKPLPALESPPDKPLEPARKVPNVFEFLEEGDSTSSSPSSSELESSEDDEPAPPVHAQAIAKIQSPKPRSSPIPHSLLVSQKPLPSTTISRSSSDSRPPPPAPTAPAPSERQVQITRRQVPSRKASPTEPPSPGKHELQITRPESYYTSRDATTIHRPPLPPSPPSSPEDSLHRGTALKRRDSSAPEVTSGYGLVASHLTHSTTQDKAAFPPLYRRFESVNHRVLLHLQDEISQMEEDLHTLDEYEEMHRVATAEKEGTKPLPASRRVDVQSQAYSSLHYRRMDLMAALVQKTEQYNTALSAYSKVLQTLPRASDDDITNYRSWMKEHNPIAAAETRFLDQDADLVALTPRLAASAAAAPVYMAIIIASGALLMPLLAFSMIAEFSGRLVVVTVTGGAAAAVAANYSSGIEALVDSRDGWRCATIYFGFMTIAAMFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFD0</accession>
    <name>A0A1Q5TFD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFD0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="456" mass="49664" checksum="D37BB5749BC59197" modified="2017-04-12" version="1">MAPSMNPNAPVEALKILPNKTHQNWLKDRGLRKLNLGIAFMFASSAGTGYNGSLMNGLLVLPEFAMIIGGLKPTIVGLLIAATSLGAFFAFTPASYIADTLGRKWCVGVGCCLVIISSVMQIFVQSHWAFFGCRVLAGAGVGTAQTAAPLLATEIAHPRQRQTATALYNACWCIGSITSAAGKNDEALVILAKYHANGDKHDELVQHEFHQICNTISIEALEPRSWGSFFSSKGDVHRLVICVMVGLMQEWAGNGIISYYLAPILASVGVTRAADQASVNVGLQVWNLFLSAGGAVASERYGRRILWLLGTMIMLFFLSLMTIVAGVFQEKHIAAAGLAVVPMIFLFFSGFNLAYSPLFIAYPAEILPFPLRAKGMAITLSTDAVACFFNQYVNPVAFSAIQWKYYLVYVGCLTWFLVTVYFLFPETKGRSLEEVSRIFDRKEVRSEDSSDTKTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFJ3</accession>
    <name>A0A1Q5TFJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012366517" evidence="1">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="37456" checksum="ED6CCC16FF4C13B7" modified="2017-04-12" version="1">MKFTRFTLSLALTSMVSAAAIPALPGADGVVGGLGGAAEGVVAGVAGGHLKRQTQVLDPVHEEVTNANIDNIEHVAVNTLGGFKRQVFGVDTIKHDLDNDLAPHLKRQLEAVQPVTEGVASSLNGVTGIAGSAVGTAESTGQGAVGTVESTVAGAAHVKRELPGVGTVKQTLSDTLGHAVKRQLEVVQPVTEGVASSLNGGTGIIGSAAGTGIIGSAAGTAESTGQGAVGTAESTVAGAGHLKRQLEAVQPVTEGVASSLNGGTGIIGSAAGTAESTGQGAVGTVESTVAGLGSGMLPTKIILFDSDPANNDPVAKRQLGNLPATASQTGTDIMAGLSGNPSGIYGALANLQMLVNAGKISPSDISNMPAAVQRVIANLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFR0</accession>
    <name>A0A1Q5TFR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFR0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6430" checksum="2767D4549B9910D6" modified="2017-04-12" version="1">MGDSINHLNDSQNRISEDSTGQILRAGPSGEAEYQDAKGIRKVTEYRVSYVGTKKPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG85</accession>
    <name>A0A1Q5TG85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG85"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="766" mass="83376" checksum="CEFA6CF16B4B125A" modified="2017-04-12" version="1">MSSSIAMSSVAMTRPGTTRPVLSQLVATPNSRSHSIWRSARSYHSIRDKMERIARSIDKYQRHPQANLRSKAETCNGWPATAHREPSSSKGWATHWPRSCFSELAGREKTYWDAQHEQMNHRIAHLKRQVARDPYEAIFGRRLVQSSHYIDQSDTATAWPGFLRAFLGAEKPMTEHPSKAHLQDFNFAQSPVRSSVSGSRDTLEYDPISGRMAPKAPQSQTGSETTMQNFNAGVDCPPGSEVEAKFVSNSSTVENGQFQPGSISSAKSDAMNSQNIDCPPRSEVETLFISESVPSEKPQSETLKVQTMAKKLSPDAGLSSGQNVECAPGSELEALFTAKPATGNDQSHSPPSFGYHPTANVSVDCQPGSELEAQFAAQLEKDCNSEPEATPVDCRPGSELEARIVAETTRAQLSDPTVDCAPSSEFEALFATNPAAVQATHYPPTMATADSDDKQPGITVDCGPSNELEAKFLSDAASTEIRGESEDLTPLRASDIRARYTDNDTSIKSRSAKDVEFNASEDRVGDVLQTQSQTQTPSTTTPAWTEADYRILAYDTTTSTVTTTSADTFFGTNPPIQPHEILSRLHNPAKFVPYFAAMQKDGYELATGGGDILVFKRFANNSNTTSKSTLDAGQHELYQVDSVLSDDVHADIARYLCHDSFDSTSYVRHYNPSSTSKPSTSGHNSNSSSSSSSGSSSNLTSSTSTPKSESKSTFRKFIRRIILTGTITAGSCYAIGVLTEYFRTGGLDGRGADGFTPFESERRHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJP1</accession>
    <name>A0A1Q5TJP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_7901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJP1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07144">
        <property type="entry name" value="ALDH_ALD2-YMR170C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP00444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="502" mass="54394" checksum="36F8D5E13B50C469" modified="2017-04-12" version="1">MSDISVQLTAPNGRSYTQPIGLFINNEFVQSKSGEKITSINPSNEAEITSVYAAGEEDVNIAVEAAHKALKDPSWKHLPATDRGHLMLKLADLIEQHKETLATIETWDNGKPYQVSLNDDLGEVTNTLRYYAGWADKVTGQTIGTTHQKFAYTLRQPIGVVGQIIPWNFPLAMAAWKLGPALACGNTIVMKAAEQTPLSILYLASLIKEAGFPPGVINIINGHGRVAGAALVQHPDVAKVAFTGSTATGREIMKMAAGTLKNITLETGGKSPLLVFEDADLEQAAKWAHIGIMYNQGQVCTSTSRILVHESVYEKFVELFKEAVKTTSKVGDPFEDETFQGPQVTKAQYDRVLSYIEAGKSEGATLAAGGEPFKNVGDGRGFFIAPTIFTNVKDNMRIYREEVFGPFVVIASFTTEDEAVTRANDTTYGLGAALFTRDIERAHRVASDIEAGMVWINSSNDSDFRVPFGGVKQSGIGRELGEAGLDAYSQVKAVHVNMGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJR3</accession>
    <name>A0A1Q5TJR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 12">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 10 12">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aguA</name>
        <name evidence="16" type="ORF">PENSUB_7919</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 10 12"/>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJR3"/>
    <dbReference type="SMR" id="A0A1Q5TJR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJR3"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="15">
        <location>
            <begin position="151"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="14">
        <location>
            <begin position="470"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP00462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="847" mass="94171" checksum="78E3A238F267A4D8" modified="2017-04-12" version="1">MPAKEDGLEAWLRYAPLPAEHVKHHPRFSQIVALSEANSSPVYTAGKEIQSGLSKILRQKVDVTNTLPEAAQIPASAIVVGTVDTFPSAAPAIEKIKEGVSSLKEDGFWLGARKDGNNGPAHVLIIGQNERGALYGAFEFLMLLAKDEPCPETYTSSPSAPIRWVNQWDNLDGTIERGYAGPSVFFKDGAVLDDLTRVAQYARLMASVRLNGIIVNNVNSHCNLLSPTNLKGLGRIADAMRPWGVRIGVALYFDTPIELGGLSTSDPLDANVVAFWNDITTQLYEDVPDMLGYLIKANSEGQPGPLTYGRTLADGANLFARALKPHGDGIVMYRAFVYNHHLDESNWKNDRANAAVEFFDGLDDVFEDNVLVQIKYGPIDFQIREPPSPLLAHLRRTQVIIEFQVAQEYLGQQSHLVYLPPLWRTILDFDLRIDGQQTLVRDVVSGERFNWKRSGYAAVVNVGNDSTWLGSHLAMSNLYAYGCYCWDPTSDERDVIQDWTRLTLSHHPTVIDTVTQLSMESWPTYENYSGNLGIQTLCDIVKTCHYGPSPAAMDGNGWGQWTRADAYAIGMDRTTATGTGYSGQYPSEVAKIFENPETTPDELLLWFHHVPYTRRLKSGKTVIQHFYDAHYDGAQDAQTFPVRWEALRGLIDDQRFKHTLFRLTYQAGHALVWRDSICNFYLAKCGIPDEHHRVGSYKWRVKAQDMQLSGYKVVSITPFEAAFGGHAIITESNNAPGTATWAVTYPVGVYNIAVNYYDHLGGTSRYQLFLGSEGSSEKRLIGNWAGDLGKHLLHDFSDLRDGHSATRIYFKGVEVHEGDVLTIVGTPDGDELAPVNYVSFLPVGIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKP6</accession>
    <name>A0A1Q5TKP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKP6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKP6"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="294" mass="30852" checksum="AA4A2081FA040ADC" modified="2017-04-12" version="1">MAPSDRLNQVNKHLNYPAGMLAGQVAIITGAGQGIGAEAARLFANEGAKVVVADIDSKKANAVADAINAVEPGRALAVVGDILDASYVETLVKRTAEFGGGKIHIIVNNAGFTWDGVIHKMTDKQWDTMLAVHNTAPFRLVRAAAPYFRVKDKEPRVIINISSTSGIHGNAGQANYAVAKAGVVGLTRTIAKEWGPAFGVRSNTIAFGFVTTRLTAAKESGAFITTPDGTKVALGIPGKQLDGKKGAEEASYPDIPLRRPASPEEAARAVLGVASPYFSYVNGETIRVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TML7</accession>
    <name>A0A1Q5TML7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_7460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TML7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TML7"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP01470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="130" mass="13852" checksum="84E8D54BA2A76ED1" modified="2017-04-12" version="1">MAYSSRPTSMLPGAGLRQPVSQPSSALSTRIAAKKAELENLRQLRDLSGTLAMQMQALESKIATLKDGTEAVACVLANWDNVLRAISLASTKASGLHDASPDEGKDPARETRLPATLVRIPAEPREKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP33</accession>
    <name>A0A1Q5TP33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP33"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF159">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53534" checksum="3A1226DEE0880503" modified="2017-04-12" version="1">MEKPTTIDNMREVEIEIDGASSSPSLSQSQEMAPDRELKNADPSDMKNPQNWSRTRKTLLFVSLMGSSLLADGAMVWGGTLVTPQAMEWGISITHSATSMNYGILLQGFGGMFAVPLIEAYGRFPVWIWPQVITMFMVLGATLSHDWSTFTAFRSLQGLFGTVPQVIGLPIIHDMYSPEEWPRMINIWGTTFMVGPFLGPALAGYIGAGTNWRDSFGVLTAIYGLSTLTVLVFGAETYYNPGKAPTSRVGSYFGFGNTKMPKGSTLWHWCKVMVLYVFKFPLLMTGIAILVTFTWPIGITTTIDSFLHSPPYNFDTIEASSMRFAGVIGALGGWLVGFIFNDWIFKRHRTNWQTEYRLHGVWFPLASMVCGLLTYGLTMNFGKHWIGIAFGWIMVNIGMVGTVVAVTAYALEKYPDQSTVVSAILNMWRTCGGFAVGYFQPAWIARNGLGLVFGIQAIVVSVSVVLCIVPVLIRERRKSVAVTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQJ0</accession>
    <name>A0A1Q5TQJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium channel YVC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQJ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQJ0"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="346"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP02489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1110" mass="125232" checksum="118B9E58B4A367AD" modified="2017-04-12" version="1">MLASLLRPKARRQQIDQTPFSFSSPLAPSDSSPWYRAARRRGAQRARRAGDSEYEHAPELQEIDEDMDQDWVGEEDEEDHEDDGPLESTPLLPIFSASHLDALPVYDLTHAIRPLIASRCETTLTWDQLRSPQVSQFLVKPIQQKLMSAHFSRATLYALMANCLQFEKEIHLNPGNSGASQTRAMVSELLAIKLLREYTTRELIDALSYEFYPLQGQDSTTAWASGLQGKRLAGTGRVSCLEVAIRAQAKRFLAHPVVVQQLEAIWAGTIVFHSAADHLHRRAHQTAVRGAMGYGTSADFRGDQTPFPGNATFRRSVTLYNPRDASLFKLSRLRVPRYRQFLSTLSFAVLLGLFLAVLQQRSRQITSLEVVFWFWSAGFMLDEIVGFNEQGFSLYLMSFWNLFDLGILLLLVCYYCLRIYGTFLTYPRNRLVANQAYDVLAANAVLLFPRLFSILDHYRYFSQLLIAFRIMASDLIAVFVLIVIACSGFFVAFLSFGSDNSPNTVAYALFQMLMGFTPTAWAMWEEYNSLGRSILTVFLFICHFVVVTILITVLTNSFMRIVQNANQEHQFLFAVNTISMVKSDALFSYVAPANIIAWLVTPFRYLMPFRQFIRLNRTIIKITHLPVLFTICFYEKMILSSQVVEPMDLVEATARTETPGQAENWRPSRFRAFSNRARLVREPSVATYQKDQALEEVFRRPFGDKRPSSIRDRQKSTVIKDWMQEIGSGPAHTPDEQDSAAGDLLEIPVRRMRFPFRKSLTGHGRDFTETTRSVASNPEDRTSRMASPVFQHHGRESISPSRTRQLSHHTDMEGDDELTSDDDHDSHDKQSDKGSGSDDKLSPIGNSEKTTPKFYSSRPSTARVLSRRASPTRRPKHSRTVSGATMLYNPIGSPNLGTDGQTTPPRDDNGSSDGEDRLPFVSTSVDQGTINRAALARNLSLNPMSVPKIDGLYLSDRPLSKRRQRSRSLLFDLGSDLGDNKAVAGAFGGAVPSSFNTQLAFATGGLRRDGPSQAQTQDMLSKLVLARMNNIEEGFREVIKEVKDLRLAGSSRSRSHSRSRPKEMRPLTARDKKKVTEKKDSKKRRPSSAENPWGQDQRNKQLAKESHSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRR2</accession>
    <name>A0A1Q5TRR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serum paraoxonase/arylesterase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6977</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="7">Glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRR2"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012366521" evidence="8">
        <location>
            <begin position="27"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP02905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="421" mass="46001" checksum="39946D30D0C48192" modified="2017-04-12" version="1">MGLLSSAFLGLFAILVATLAPAVVHMIKIGGPFLTPNLTVLGASQGPIVIEDTIHCEDLHHYRPANLLFAACEDLKDTRFGWFPGLGHLDTKAAAGRGSIHVVDPKTFKSTHLELENFNGPFVTHGIDVIEDPQNPSAVYIFAVNHLPNPDFTSTSNTPDIPAARSQIELFHHILHSSTAQHVRSIRHPLIQTPNDIYAHSPNSLYVTNDHFYRSGFLRLVEDVWPSAKWSNIIHVQLHELENVADATSSLTASVAYSGLWNNNGLGHARSDVEIVITSAIGGELYLATRHENNTLSVHDTIVFNTVTDNPSYYVDPYASAKHDASGFVVAGVSQGFYLPQTGRDPDALEAVQVWYAKPGSGSGGEEAWEKRLLFEDDGKRIRSASAAVLVPVEPEDGMKKAWLFVTGFLSENMIAVQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU60</accession>
    <name>A0A1Q5TU60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU60"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="134"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="26074" checksum="4E6D7608C2742A3C" modified="2017-04-12" version="1">MTNFKIQIISDTICPWCYVGYRRLSRAITAHKANNPTDTFTLTWNTFYLNPALPDFPGVNKAEMYTVKFGPERMAAIFSRLSSVGEGEGIKFNFGGNTGKTRDSHRLLWFAGQLEEKKSSPSPSTSGDTSAVGGLQTRVAEKLFRAYFEDEKNITDPRVLLEAGVEAGLDREAVKKFLDSEEGGAEVDSEAKVASRRLVTGVPYFSIQGKYSVEGADEPETFLEVFEQVKEDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUA2</accession>
    <name>A0A1Q5TUA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUA2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUA2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="18557" checksum="0540213A3CDDBF1C" modified="2017-04-12" version="1">MSPSNTPKPFLGNGRPQTDQKQTYSEWAKDIYNDQYEKWVPWIEDQYLKWFGKGDNKASYATKDTLSKTKVTGIDQVDKIQDDTSNLVGNQIGDKGLLAPVGQFASREGANRAERNGKDDSGSYMGPATGLFEKGKEGASSAGSGLAQGAESVQNMTIGNIPGARGVLSGSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXS7</accession>
    <name>A0A1Q5TXS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXS7"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP04993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="126" mass="13447" checksum="86C229058273F810" modified="2017-04-12" version="1">MVSHLAKSAVGGQTLAGVKPKAGASPKALIALEKRTGSKIVMVTNLEIFVIIPSLLVEELQKKCASSTSVTQAAGAPKGAMEVLVQEDQRKVIDAALASRGLKSQWAEVVHRTMTKKKKKKKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1E6</accession>
    <name>A0A1Q5U1E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1E6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="110" mass="11952" checksum="7F24A09C9F60C18D" modified="2017-04-12" version="1">MASDQTQGGAISGEHEQHVLSPLPDSNQSNQESYWQDTARLPLHITDINGMTGLSPPQSTSEGNVFHCEGPGDNRMSGFPVMFPFTNLFEDVGFSPDAYTGSMLRCIMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1S1</accession>
    <name>A0A1Q5U1S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_6430</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1S1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1S1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP06440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="683" mass="74496" checksum="AD702E3BCAC7E49D" modified="2017-04-12" version="1">MGYTDLDTLAINTIRVLAVDATTKANSGHPGAPMGMAPVAHVLFNKFMNFNPKNPDWVNRDRFVLSNGHGCMLQYALLHLFGYDLTIDDLKSFRQIGSKTPGHPEAHDTPGIEVTTGPLGQGFSNAVGLAIAQAHSGGVFNKPGYELFNNYTYTFFGDGCAMEGIASEAASMAGHLKLGNLIAIYDDNHISIDGDTKCAFTEDVLQRFEAYGWHTEWVKDGDNDLQAIEDAIRKCQQVTDKPSVIKLTTTIGFGSKLQGTHGVHGNPLKTDDAQHVKKLFGFNPEESFAVPQSVYDLYHAHGAQGAAKEQEWNALFQKYQQEYPTEGADLARRLAGKLPEGWEKSLPVYTPADPAIASRKLSEAVLEKIHDVLPEFLSGSADLTGSNNTRWKNAVDFQPPEYGIGEWSGRYLRYGVREHAMAAVMNGLAAYGTVIPAGGTFLNFVSYAAGAVRLSALSRVRVIHVATHDSIGLGEDGPTHQPIETLAHFRALPNCMVWRPADGNETSAAYYMALTSKHTPSILALTRQNLPQLENSSIEKAIKGGYVAIENPEATVTLISTGSEVGICVDAVKTLEAQGVKARVVSVPCFEVFDAQTKEYRLSVLPDGIPVLSVEACSTMGWERYAHEQFGLNRFGASGPYKEVYAKFEFTPEGIAKRAVATIEFYKGHTVRSPINRAFQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U243</accession>
    <name>A0A1Q5U243_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PENSUB_6507</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U243"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U243"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="40"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OKP06517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="434" mass="50049" checksum="98716BE7F36EE300" modified="2017-04-12" version="1" fragment="single">PLKADSGPIHLYPPNSRPDHPTSTPINTRTMSNKKIEQWEIERYWEIFSSLSNGQTHLNSSQAASVLRNSGLRDDQLEKVWDIADVDGDGELDFEEFCVAMRLVFDLVNGELQEVPPVLPDWLVPESKSHLVAATRALHRPEQFERIEEEDDSLGLKDGFDWYMKPADRSKYEEIYNSSRTQRGDITFESLQPLYESLDVPDTDIRSAWNLVNPSASQAINKDATLAFLHILNYRHEGFRIPRTIPASLRSSFESNQIDYQIDNNARPAQRWGADGDQETRTGRKAKFGDTYLSRLGVGGKGSYQPKGTDFSETIQDEEWEKVRLRRELADMETKLQFAREASETRRDRPRNDGRPNWVLIKKEALQLLEYKERELRELREGVGRSKDGQDLERAREDVKTVGEQVESLKSHLAQRQGVLADLRHEIEEERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4Q0</accession>
    <name>A0A1Q5U4Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6047</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4Q0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4Q0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="544"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP07458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="628" mass="67097" checksum="07FADAAED5DCE923" modified="2017-04-12" version="1">MAAPQVIVVGGGLSGLSAAHTVYLNGGNVLVLDKQAFFGGNSTKATSGINGALTRTQTDLGIGDSVKAFYEDTLKSARDKARPDLIKVLTYKSASAVEWLQDVFNLDLTLVSRLGGHSFPRTHRGHDAKFPGMAITYALMQRLEELAEAEPTRVQIVKKAHVTAVNKSGNNVTGVTYTLNGETKTADGVVVLATGGYAADFSDTSLLKKHRPDTYGLSSTNGTHATGDGQKMLMEIGANGIDMDKVQVHPTGLVDPKDPNAKFKFLAAEALRGEGGLLLNSDGQRFSDELGHRDYVSGQMWKEKEKGKWPIRLVLNSKASKVLDFHTRHYSGRGLMKKMTGKELAAEIGCGDAALKKTFDEYNLIADGKKKDPWNKKFFHNLPFSIDDEFHVALMEPVLHFTMGGIEINEHAEVLNGDKQPFNGLYACGELAGGVHGANRLGGSSLLGCVVYGRVAGDSASQHLFQKLLSTGSSGAQKRLGQISLHIDPSTPGKISVEWGGAAAGGSLPSVTAAPGAASAAAATPAGEDTSAKTDPVASFKIPEKEFSMEEIAKHNKKDDLWIVVKGIVLDVTNWLDEHPGGANALFNFMGRDATEEFAMLHDDEVIPKYAAQTVIGRVKGQTPSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U834</accession>
    <name>A0A1Q5U834_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U834"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U834"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="254" mass="28092" checksum="C25217421248BC16" modified="2017-04-12" version="1">MPSKLDTGTTQNELQEIKHNQNVLQEQNEKLHEELRALRTQVGNASAAVTATRTWAAVAAHRGNAMPLLNNQQPEKEHNCIRISTQRTFVDPRDNENSGGNAFGRYLPIDAVNTHIRTALQCDVATQDAQVAGIGTIKTGYLIRFKDTESAEAAHNNTQWLDQLGNNTKLVKPRFGVVVHRTPTEEFDLETGAIQAAEKIINDNDLAEHGFHIDELAWMKAKNKALGKFASLGIRFDSAEGAEYMLQPALHSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8S7</accession>
    <name>A0A1Q5U8S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000561">
        <property type="protein sequence ID" value="OKP08905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8S7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U8S7"/>
    <dbReference type="OrthoDB" id="4573177at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="118" mass="13255" checksum="6D01FC3A02CCD1F6" modified="2017-04-12" version="1">MSPTRAVRNMMRDYEIRLLLKPSAVLNPEHEVTATVLSTFEMPPTVTKLNVQFLDNISRDLYAADWSARIRKIENDDNFELTYKKRYAVTGGDIDAALVAANNDGFNAGSAKFEAQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9T9</accession>
    <name>A0A1Q5U9T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Single-stranded TG1-3 DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9T9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9T9"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="225"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="351" mass="37141" checksum="A3B18174651563DF" modified="2017-04-12" version="1">MSAVDALSNTLATTNINDTPNTNGTPAASQPTDAAAASADEGRRLYIGNLAYATTEEELKDFFKEYTIESTSIPVNPRTNRPVGYAFVDLATATEATAAIESLSGKEILARKVSVQLARKPEPAEAKEGAGSGGEGASGNEGRKRTGGRGRGRGRARGRGGRVARGRTQDGQESTEVNASEPAPLAETTNENEPAPTEGAKQGKPRAPRPQKQRGPPEDGIPSKTKVMVANLPYDLTEDKLKEIFADYSPVSAKVALRPIPRFMIKKLQARNERRKTRGFGFVNLASEELQAKAVSEMNGKDIDGRTIAVKVAIDSPGKEDDVNAAADQYEEANTPAQENAAPAAVPAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9U3</accession>
    <name>A0A1Q5U9U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9U3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9U3"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30907" checksum="95AAFAB792E63BC3" modified="2017-04-12" version="1">MSAQTIAFLGATGGCTNACLSYTLLNGHNAIALARNPEKLTTQLLSQPGLTQSILDKHLRVIQGDARDIETVMKTLIVSTTEQSTTLVTHVISGVGGTGQFVLSKPSPCAQIPIRIPTIPHISIPNPHITEESTSALLAALGRIADERFTCFDEYAAVAPRVTIISSTGIKKGVRDVPMLCKPLYAALEVPHKDKMQMERLLTLEQERKESLLCGGHVIVRPSLLGGDHRIAGPGVDSGYARLRVGTERRPEVGYTVGRALVGEWIYREVVKGGGDRWVGEGVILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9W7</accession>
    <name>A0A1Q5U9W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9W7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9W7"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="933" mass="106449" checksum="68057F553B5A4F85" modified="2017-04-12" version="1">MFANAANSTPAVPSRNALRVLRQLAFAGSTVGSFCGVAVITYDVHRRVRVAEQIIENKRTLHTSAPNYDATASAQRLAVMMEAAEAGEFMGLASLKNKKAVPTEDKVEALNEQTLVKPSPPPAARPTPRWFQPGQSNTSMPPVSDSATEMRLRAENRLALAREAREADIARAAGEPPLEDRIRDLIQEDREIEAAQFFMDNVPAGEGVTISMDRRDLLRRLFAANCMKGNIFIARSLFRHMEKLSELDSEIWSTMMHLLAKEGHVESVGAIFEKHHTRLTVPPHLLEVIIRSLLESRRLTLAKSLFYARIKHDDNGGLCGAYLDGLWRKTRKLELLKTEFNKILTALAELNRGPTEKVFNPMVKAYIEAGAFEEAEALVTAMPSEFNVKPGCRTLGLVLYGKALQCNWEGVMNGLREMHELGFTQDKKSFAVVFDRVFLEYYPTQPGPQIFDFLMTCINEFKIRPDKILHRHILEAVVERCDSSCVRAINEMADERNWNSGVDQYELVRILEARRVSMQDTPVGIWRMLQAAKQQYGSVATNRRLMGTDADKFSLRDHVLQPIHSDADKTFPESMKNLVNSRSMNTYMSLAKRQEHHIHAGNFTKAISAFRQASKSGHPIKPIHLQLAVTSILLDGGMSGLKDAQKLIKSEWPYWSRVPKTQFTPRFPRFVPIFFQQILQVERAQTPESTLFQMALFEFYKICEHTPMFNVKHHLSVSIARRLIREGQSETAIGVLTAVYMSKWRRSHGFDQVQLKILMRAYAMTGHIRGVWWCMMTSLSRQEPVLDDFLVEVKRLMPLLNKRYSEQEPESLERRNMAKLEFIKDKLEDKAAGRPYWKGQIVSVCPEKKQKRRALIHTETGRLYDRLPSAPISKMVETFDEEMEMDYLQKRTQVGFYKLQTSWDENRMVTQSLVQPEEADYPSSLPKRNAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAF2</accession>
    <name>A0A1Q5UAF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000520">
        <property type="protein sequence ID" value="OKP09445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="285" mass="29351" checksum="2E77B122B6C16EEC" modified="2017-04-12" version="1">MSASCTQFDAENDSEAELAYLSSSIQSVAKTSGVDARFILAIVLQESNGCVRVGTTNNGVTNPGLMQSHAGTGSCGSQKDSACPESEILQMIKDGTEGTTSGDGLRQCLDANGGSGETAYYRAARCYNSGSIAPSGNLGQGGSTHCYVSDVANRLLGWSSGPSRCNEATVGSLTGSSSQGTSPVAGSVSIASSTFATSLSLPVSVPLIQQSTTPSLTAEASAIPTMVYPYALSSCLSYATVSTGDYCEKLETEYGISAVQLRDWNPGLDEACTNLWCGYSYCIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBH8</accession>
    <name>A0A1Q5UBH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBH8"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012343785" evidence="1">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="535" mass="59189" checksum="CB0EDE085CEBE295" modified="2017-04-12" version="1">MHYFLSTIAVGWFIAPAPALARSIGIGSGSSTLCATNGRQVTHHDSNIWPWQTYQSSNITPPYLTINRTGEDLASGLLFIGQENDGSTGVKQVSPFILTHDNELVWGGPEGDSSNFRQQYWGNQSVITFWIGTGKAAYGADAGRGWGKVQIYDDQYQLIKSVCPRLNLTMPTGTTTDCDADVHESFITEDNTILVTAYNTTQADLTSLGGPKDGWVYDSIAVEIDLATNEPVFIWSPLAHLDINSTHEEYSSSSQTAPFDWFHINSVQKWNDHYLINSRHLWRTYLVNRQGEVVWYIDGEDGGSFESLPNDITFSWQHMARLRNVSSTQALISWFANDLDTATSTVPSKGLTLRLTLPPSPEHPPELVTNFYDHQYPVSSAAEGSFFPLPNGNTLMGYGDEPYIKEYGPKGDVRWSAQFAGYDLGQSYRVYKQQWQATPSTRPSLVVTKAVANDDLKQCAGKSSSLRGYVSWNGATAVEKYRVYAGIDSRSLQILGDVDKKGFETKFSLPSGIKVVKVAAIQAGKIIRKSAIVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBR2</accession>
    <name>A0A1Q5UBR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000436">
        <property type="protein sequence ID" value="OKP09901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UBR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="696"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1532" mass="171097" checksum="68055A1169D0D4DF" modified="2017-04-12" version="1">MMTRGRQSQGRKPQQTDIPPEGDEVDLGDDRNPSTSPRRETPDADIKAMLTQLTASVSALMQNQAEQGRRLDALSQLAPRDAPEPIYPSLSAEDRTDDPNPRIDDLQTPIAVDREEALIERELQKLRRSIKDLWEHKPTTLTMHNFTAWKTNTLSDASLIDIHDVSSYSILFKGQQHPPNSYSRLQRAIWTAINDALHARILKSLSVEIRKIMPPQRTKNAAALWESVVTGFGITKAQERYNLLRDVCALKLDGSDYMSHQAQWLTYMAALDDLDVTVDDIKHDLFILSLGNWQSQFIKTRLDEFFASGGNGEPIVNLDIRQLMRALQYRAITQGLKKKDPVSTPKGSTSTSNSERPKSLEKSDSDRPSKSRCDYCQAPKAIHDASRCWSKNPEKAPMHWLKDNADLVRRIRGRNGDPIPDIPGLIVEPQAQAKAAISSSNNNGRQSTDWYFDTCASRHVVSDRELFTSYAPLKSSEGIGSIWGDKKRAIGVGTVNMKLNGLTVTLKDVRHIPGADSNLVSEALLHDQGFIIHKNSTPPFHYVLKDPSNQRFFAARNSSDVYTFTADEPFEFSTQAFVTIANPADSHLTIDEPIPTAGEQQLVAYFSSNAKSNVEAKPSDGDEHVSKASIDIKSAFPKTLWEWHVTLGHLNYRDVLYLANRPGSGVKITGDKAQPPCQVCLQANITRRYSRRQATRATRPLMRIHVDIVGGGDVFSDDDDASQAANLQSRHGYRYFLLITDDATRFRWIYGLKSRDQCEIATRLRYWCQHISNLGFKTPAFLRSDNEFGSGELQSMMTEWGCQWEPSNPYSAWQNGTAERANRVVLEKARAIWIASGLPMTFWFHALVAAVFLANISPTSTPLYNNPTPGGTTIDESIQPQDTRIPIEAISKIPADLSYLLPFGSSVFYHLHGTNEPTGKLEPRGKMGRVVGYNGASIYTVWDPDTGRIFNTGDIRPTGAAIQTLLQGGEQVARETPDLISSEELMDPITDDNWIRPAKDLKAFAAMTKIFRSAADAPRSFKEAMEGTDRELWKAACRKEVDDLHTRNTWELVRTGDVPIGLRPIPGKWVFTKKQGVDGTTRYKARWVIRGNISNGHQSLWGETGAPVVMASTKLVLFAAAAHFGWHIAQADAITAFLNGKLPNSVYMRQPYGFEQGEKGTLVCKLKQALYGLIPAARIWYDTLREKLEAIGFRVSPYDAGLFIHKAKPSLYVTAHVDDFGIIGADRTEIQWVLAEMGKQFPIKDLGQMEHYLGLRVEQTEAGIKLSQPDFIDNLLEDTGMTDCYPVSTPVEPGLVIDDLYDPSIDKRQYQSVTGSLQWLASHTRPEIARVATLLAQFNTVPTQKTLSTQRRVLRYLKGSKQLGILFRLGNGALPRPVLYTDADWGGPLTPGRRSCSGYVMLLAGGPISWRSHLQTSVALSSNEAEYMAASDAAREVEWLARLVADMGLYAADATPITFYMDNKGAHDLVRTSFVSRRSKHIDIRYHYVRDIAARGIISPTPIGTRDMAADGFTKPLAEEPFRRFRNQIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCG9</accession>
    <name>A0A1Q5UCG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11534</name>
        <name evidence="4" type="ORF">PENSUB_4432</name>
        <name evidence="3" type="ORF">PENSUB_4434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000717">
        <property type="protein sequence ID" value="OKO94676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000384">
        <property type="protein sequence ID" value="OKP10157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000383">
        <property type="protein sequence ID" value="OKP10159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCG9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCG9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6450" checksum="4FEEBEF3ED720694" modified="2017-04-12" version="1" fragment="single">RILDLGCGWGSITEHLARTFLDCPRIDAINISQRQLDYFADTIPADLAACVHLYLCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDK2</accession>
    <name>A0A1Q5UDK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_3843</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDK2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000084">
        <property type="entry name" value="Transcription factor TFIIH subunit Tfb4, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="367" mass="38944" checksum="3DDEA038CDC6DD37" modified="2017-04-12" version="1">MNSVDASEHYELGATALEGSLPLSKAVANILVFINAHLACNYANEVAVVASHTTKAIWLYPVHNDAISQESADPDGDVSMNGDSVAAPQTNKYRPFRLVEEQVTRKLKELMDSTSSDDLRGNTSTMLAGALTLALSNINRRTIAWAEEHGGADLEDAAGDGGSGGASAGAGAAGTGPGRYSASNDDERLQSRILIVSVSGSSDSAHQYIPVMNSIFACQRLHIPIDVCKLSGDAVFLQQACDATKGVYMALSEPRGLLQYLMMAFLPDQRSRRHLVLPTRVDVDFRAACFCHRRVVDIGYVCSICLSIFCEPPPGNDCLTCGTPLDVGDFGSKPALIPRKKKKKKRANGTSTVGTPMSTGTPTPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDL4</accession>
    <name>A0A1Q5UDL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDL4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30984" checksum="BA8A457EA3CAD8D0" modified="2017-04-12" version="1">MVIAYLPQHELDAKEDHPYPEPAIPPFAGRLGGNQDFILDRNDPKNVKVLEQVPDAAPCMTVAEIFDLRGFASPDLWKFAMLECVASLMNVFISCWVTTHPLSKTTSPTTEAGVYTTVTFFSPLFGGITNLLLTPLLIFTFSPSSGGHISPTITLATFFARIISFPRMVQYIGGQTLGGALAGFALNSAYGNREFTVGGCHIDSSMVPAKDGLVIEFFACLILFFLAFGVALDPRQAKVFGHATSPWLVGIVLGIVSWGTAFTREGYIGATSDSTLTSLEDVHGKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDN2</accession>
    <name>A0A1Q5UDN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein MLH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDN2"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="248"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="760" mass="83745" checksum="308D6C909D318B90" modified="2017-04-12" version="1">MAGEMDVDVPEQRGEKRPVEETDVSGPPKPKRIKALDPDVVNKIAAGEIIVAPMHALKELIENAVDAGSTSIEVLVKDGGLKLLQITDNGHGIDREDLPILCERFTTSKLKEFEDLTSIGTYGFRGEALASISHIAHLTVTTKTAGSSCAWRAHYGDGKLVPAKPGQPAAPKATAGRGGTQITVEDLFYNVPTRRRAFRSASEEYAKILDVVGRYAVHCAGVAFSCRKHGDSGVSVSTPSAANTIDRIRQIHGSAVANELVEYKVSNDKLGFRASGLATNANYHVKKTTILLFINHRAVESTAIKRAMEQTYSAFLPKGGHPFVYLDLEIEPNRVDVNVHPTKREVNFLNEDEIIEMVCDEIRSKLAQVDSSRTFLTQSLLPGVQTIETLQQLPKDDATEGNAGATPKTPAPTKRPYENNLVRTDSKIRKITSMLTPAPIPSPSGPGVSTEPGIPQPPIQDDGLQYEITDRQPLRIALTSVKNLRSAVRATMHNTLTEMFASHTYVGLVDERRRLVAIQSGVKLYLVDYGLTCNEFFYQVGLTDFGNFGEIKLDPPPKLVDLLQIAVDAEKEEQADGNNPEAAKILANAAELISRTLVERREMLDEYFSMKVSEEGELLTLPLLLKGYVPSLAKLPRFLLRLGPYVDWTGEEECFRTFLRELAAFYTPEQLPVLPSPPSNDHPAHLNDETGQEVPQTNEDSTVAGNEDPLIQARRTQMMRMLEYAVFPAIRSRLVATSRMLKGVVEVADLKGLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDU5</accession>
    <name>A0A1Q5UDU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDU5"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="27446" checksum="64F31070D8415604" modified="2017-04-12" version="1">MSDVAETKPDPTTQAPEADKPTTGEGEKTVTEVAADKATEVAETAKDAAVKTSDTVFSMFGGGPKKEEKPKADEEENDRSGSAKAQKEEKEEDVEADKVVADASWVKTELKDVVEVKTGEEVEEQVFKMRAKLFKFDPESKEWKERGTGDVRLLKHKENLKTRLVMRRDKTLKVCANHYVVPEMKLSPNVGSDRSWVWNTTADVSEGEPEKQTLAIRFANSENANLFKDAFEKAQQENEKIFGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE48</accession>
    <name>A0A1Q5UE48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vegetative cell wall protein gp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE48"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE48"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48075" checksum="6417CCB368880E78" modified="2017-04-12" version="1">MYHYSSPPQGWSTYDYTQSPPTSQYYAQYASQYANAYASPRGTSRRHTRKASYTATTKEPGWHSTYPQSYYEATPEYGIPSRKHDHVSASFAGPKHRRSRTTGHPAGDGLGAGTGFKFGFHPSSQQPPIFVDVADAFDTPHHASFHKMQPPPHEAQPQPRPARHGRPPAAAAQTSTPRDGPGQHRRTASTSYRKSSAADSHFYFTQAPNHEDIESARRSRARRQSTSTRTPSKPKPAPPSSKPPPVATEEDAERAGIPPGYSTKNWDPTEAPIILLGSVFDANSLGKWIYDWTVFHHGASTPMADVAGDLWLLLIKLAGKVKRADECLPRIQSPDAQDIVEDFLESGDRLWNRFKKLLKACEMFMWKAAKRESGKGQVSMGRNAGCEFVDSIFGRDRELENTEKLMNSIRLWNMRFDANCEDILRRPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFQ5</accession>
    <name>A0A1Q5UFQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFQ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="96"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="278" mass="29882" checksum="8186BB84950258F1" modified="2017-04-12" version="1">MHTTVAYHNSLETCDLATMHISSLLPLTILLGSLSPAGAIPVAEPAVDGIYARNEDIHYRDSSIVARDGPGFRMESVKYQGISPLGPSGYGSPQCDSVTDDTEAINNAISSGTRCGKDCFSSTVTPAVVYFPSGSYVISAPLLTTTTRHDWQPKPTASPEGDYYHAIHDPDFASTCNVSSCNCALGWGLRVIDSEDLHVYGAGFYSFFNNYDATCSAYGGPQNCQNSIFSIEGQSAISVYNLNVLGSKRLVDQDRKSLASYSDNIGVFTNNIAYFSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGD8</accession>
    <name>A0A1Q5UGD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Could act as an H1-type linker histone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGD8"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000383">
        <property type="entry name" value="Histone H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF36">
        <property type="entry name" value="HISTONE 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="10">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="214" mass="22042" checksum="628B1AF64DDC9D90" modified="2017-04-12" version="1">MPPKKATSVTKKAAAPAHASYRDMIKDAIVNLKERNGSSRQAIKKYVSSNNKINVASQATFDAQFNKAIKAGVEKGEFTQPKGPSGPVKLAKKEPAPKPAAKPAAKKATTAKKPAAAKATAAKKTATSATKKTPASKAATTTPKPAAAKKATATKKTTAAKPKANSGKARKTTTTAAPAIVEQPKVIGKTKSGRVTKTTAAPKPAPKKRATPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHB3</accession>
    <name>A0A1Q5UHB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000270">
        <property type="protein sequence ID" value="OKP11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHB3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="518" mass="58743" checksum="3E2DA67723BAB6D9" modified="2017-04-12" version="1">MTTNHDTDTSEDDGLMAQANEPLKRELLQSQKLTLTTYRAPRRVVSLGISPSYVKDWMPADAFRELYQNWYTPLRFLYCDAISENQVDRVDRSCPRHGKPTLPCAEAVVIGATRAKSGRPVALDAFVDWLRLTTMDIRGLTCPSGIISSPHGDLILDPQLRGQLYHNGITLANSTVGGAFLFAYNFAYSSTCRDRRRLASWRDAARQVQQIWEEALCKQVDTILPLLVDLLRNHARSADAEMIGPHLEPSAARQIWQYLLRESADKEFFYNESCNDQTTNMIRDNLGKRPARLPDTLWHMLRAHCPIRTVEEEQQKLFKDAKPCVVPDTTFARTVDCALRACFALLSFTDHIQVFYVRGSAGKVDAYFDKGQAHPTSRPAEIKFMRQIGRRLRYLLHSIKLEPYPRGILVSWEDNETESVRTLGPSGPDYHVVLHDDNCANAETALLHDKAALPSEVVPCGCRQQFARQTHRMCLFTGLSHTSTYYAMIALNEDRAFYGVPSNRLLPGSYEKVENISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHC2</accession>
    <name>A0A1Q5UHC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHC2"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="411" mass="44929" checksum="A1806B3A58AF74C4" modified="2017-04-12" version="1">MTVTSVGMEEVRAAVNVALDELRESLRKVNQEIWSNPELAYEEHHAHDTICTFLEKQGFTVTRHAYGLGTSFEALSGSGGRQINFNAEYDALPGIGHACGHNLIATSSIVAFLALSFALKKFGIPGRAQLLGTPAEENGGGKAVLIDAGAYKNVDISLMAHSGPKKLFPDQEPSDGIAGTLMNARKNIHCEFSGKSAHAGGNPWDGINALDALVTSYNNVAVLRQQLLPEQRVHCAFMDTPKVANVIPSHTKAFWQVRSPSLKGLNNLVTKVRNCIEAGALATGCSVEIKEEELYTDVRLNDILCERYQVHMGEWGRKVLKRHDKVLTASSDIGNVSYVTPTLHTMFGIPTPENTFPHHPTYTACAGTDEAHEEALIVGKALAMIGWDMITNDTLFETAHQQWKKEIERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHD0</accession>
    <name>A0A1Q5UHD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHD0"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="32294" checksum="562DE01AE01F5200" modified="2017-04-12" version="1">MQPHVKQTASTRALVLPEIVTSIMHQMDMRTLITTQRVCRAWSNLIQTSHSLQKALFLVPDHTSKDPSNPRIYNPLLAETFPSFFPSTIDNDSIPKTTLTTLPFTSNHKTLKTHLRPEASWRHMLTTQPPLHTIGRFIMGSGMMGQTWHQQKALPQKNGLRMGTLFEMIIQLDRYMWNNCEIWISLGGAVPVNAPAEMKKPSIYLDVDRINSDWEGMLRETDLVLVTGGHVDCTDPEGPEDPEWVKSEDELVWEEICACHEELGITMDDLPMEKYNEGWAGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHW2</accession>
    <name>A0A1Q5UHW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHW2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="20537" checksum="CDAED58A5E243B4D" modified="2017-04-12" version="1">MKVTAPILPFIASATASCLHGTSLLPRSADGLVEINSFNYTNTGGPLTWYGLSEKNFACSKGKHQSPIDIVTEDIDYAAANSIRFNVPSADNAKFENLGSGLAAFAVVGLVFELPYFSNSTPLFDSVFAHIDDIATPGTYTKTDHLDFTALVAHLNSHGIYRYTGSLTTPPCSEKVAWFLSTEPLPLNVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI34</accession>
    <name>A0A1Q5UI34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI34"/>
    <dbReference type="SMR" id="A0A1Q5UI34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI34"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="308"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="56330" checksum="CEEE4B104DDC3E5A" modified="2017-04-12" version="1">MTSFTKLGDHETPVIAVHPSRRVSKINPNIYAGFTEHMGRCIYGGIYDPGNPLSDENGFRKDVMGALKDLNIPVVRYPGGNFCATYHWLDGVGPKDQRPSRPELAWLGTETNQFGTDEFMKWCEELGTEPYLCFNFGTGTLDEALAWVEYCNGTGNTYYANMRRKNGREEPYNVKYWALGNEVWGPWQVEQMTKEAYAHKALQWAKALKLLDPSLILILCGQDGTATWDYYTLKQCLLPAHSALSTSAVPLIDMHSIHMYTCSNSHLPNATAPLAAERAIEITSSLIDLARIENGVPPSQPRPTICFDEWNVWDPIRAEGSRGAEESYTLSDALAVAIWLNVFIRKSRDVGMACIAQTVNVISPLMTTPEGIVKQTTWWPLYLFSRFMRGWTVAAHVSCGTYEGETAPVWLRSAMETPWLDVSASVGEDGHANLVVVNIHEEKGFETKVEGVSGEVEVFTVTGDGVAATNMKGNAEEVGVKESKWDGQGNYTFPKLSITLMRWKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI46</accession>
    <name>A0A1Q5UI46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI46"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="695" mass="77022" checksum="A6B8188946B86E67" modified="2017-04-12" version="1">MNAGRYYSSNISAIGLRAREPAHEEDALLEPPNEHIYHDTDPRLVNLAATQEQRESISTINPGEDEGPHTNESTKGSSPLCYKFANKAMLGQYIPELDEASPRSKTRKNEASKRAKMVRNQLITAVAVSITNIVVLTADLGRVFTSSWNSVIFTSTPVVSYARAILTSDFREAGRDWSLDPLPAVLNGKNWASVHALYAEMDNFTRLDKQGCIDAYIDPLTSKGSLVIVAANITSAQNNNNTLLHGWNTGWDVWSRAPWWICEAYNRDEMTLLCTSEWANTLVDDWTVFAWTQHKDPGWPFRVQVDYCIVGAQSDISQQCGLHYGVQVLAVVSVCTLIQCFLISVVWLASRSTSGRSKVERTMVLMGDAVAEYLEHRSDLSNHRSVSVYPQVWNPRHRISWFKSVSKKVWAVSLLLFIIGILAPLVVLIQAVVSWKARGVDLTPLTIAKQGFGVNAGFLGMNSEKGDYSLITCVFLANIVQLLVSFLYLLYNNILTRQLVADQWVRFLRPDGKKPLRVSLPSGMQRSSYILSLPLTYSITLMIIMIVLHWLVSQSLFVVQTIGFDTAGELVHFPSFNGSAVGYSPLGMVLATACGVIMILGLLINSLVRGHENVPAEFPTWGSSSAHIEVMCQRPDQDIDAHLFPVSIGVVSDTSAGSDSDSLSSLSRIAFSTQVGLRPPEDKETYLFPVAHRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI58</accession>
    <name>A0A1Q5UI58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI58"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI58"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="11"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="40932" checksum="9BE0A7C14EDE900F" modified="2017-04-12" version="1">MAEAQAPIAAVKVEALVVMKIIKHCSQTFPTTATGSLVGMDVDNTLEITNTFPFPVVETPTESHFDNAAPNPAAAAPRAKSNAAYQAEMVRMLREVNIDANNAGWYTSANMGNFVNMNVIENQFFYQKELNERTVALVHDVSRSAQGSLSLRAFRLSAKFMEAFKDNKFNSEELQKSNLRHQDIFEELPVEIHNSHLITSFIHQLQCPTPAAPTELPASLSALEASPFSKSTTLTPNLDNLSLSIDPFLEKNCDLLLDSIEAHNTEVNNYQYYQRVLGREQQKINNWKQKRAQENATRATLKQPLLPEDEWQRLFKLPTEPSRLESMLNTRQVEQFSRQVDNFVSATTGKMFAVKGNLLPGETAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIB3</accession>
    <name>A0A1Q5UIB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIB3"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049256">
        <property type="entry name" value="Get5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17183">
        <property type="entry name" value="Get5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Get5 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Get5 C-terminal" evidence="3">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24728" checksum="A8503E42654E5BB0" modified="2017-04-12" version="1">MSELAFAKSFLSSLDSRPIKLRSDHVFVPERVGLRVPYTLPRLQAPHPEMPKKTKQAQAPGASKSVNIKVKSARNPALEFSITNAPVTTTTVQDLKDAVRERVTDAQGSPVALDKIKVLYRRKPVPGTGKTVAEVLADEPEMLAGGKEVEFGVMIIGGAKAIEAVESQPEVAQEQDVPKPAVGPSGAEVLQTEAFWDDLQGFMEQRLKDADEAKRLAVLFKGAWSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIG7</accession>
    <name>A0A1Q5UIG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Striatin Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIG7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="7">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="748"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="583"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="827" mass="89442" checksum="0FF22D51BBF02C46" modified="2017-04-12" version="1">MSSLGGMSGGMGDSNGGHPQGTEYTLQGVMRFLQTEWHRHERDRNAWEIERAEMKSRIGRLEGELRTSKRMQESLGKHVRLMEAALKKEREKVKMLSNNESVEGLQDPKDIARESVNFLKEQRSASKSNTDAKPEDPTNPESQEIANEDERDKSRVYLSKCAQEIAYHVIPTSHPVPDLSDPDLSGHLYGNQQLSQQNLEEAFLQQQRQKANHMISREAVLANHQQPGNQYSENAPPSRAQNQYNQGPLAVERRQVEQQQQQQQQTPVTAIDNRKLAYEQGLLDERAATGTQQSAHDAPGPSVAVKEDLQSHHATEQSTEDVDGWNFDEPAEKAPIAESIPPHRPDTDAFPNANFVRGKSPSRGGSLSHRRKSSGSRRKSDGSIEARDFGANAGQQDPGFKVRFALRGHLDVIRSVIFTGGGSPAEPEICTCSDDGTIKRWIIPATYGNFNAQGPSSSSDLDITSYFTHRGHNGAVTSLAACSPSQNISNGGRALGDGWVFSGGQDASVRVWERGRVDPKATLDGHTDAVWGLCVLPGTAGSVFGDSSSHYGGSDRILLASGAADGRILVWAVSPPPLASNPQAGSRRQGGSRRANSISSGSNFPSSPQPSVATSTPFHYTLVHHIIRSDSPSPTCISPLSLAGVNFVVSYSDASILVYDTRTGEEIVGMASLETYDGTPSTGVNSVVTTTVGFDGSANLDPSRTMAEEEVVHGATGSSSVEGVIISGYEDRYIRFFDANSGQCTYTMLAHPAAIASLSLSPDGRELVSAGHDASLRFWNLEKRSCTQELTSHRLMRGEGVCAVVWSRDGRLVVSGGGDGVVKVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX6</accession>
    <name>A0A1Q5UIX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000214">
        <property type="protein sequence ID" value="OKP12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX6"/>
    <dbReference type="OrthoDB" id="10449471at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9650" checksum="484586A64464F34E" modified="2017-04-12" version="1">MAYIDTQPLETFIFEGLRQFVGEHAGSRQSVDTASEVVHSLSLALKNTVLFSQDLHPSDFSSQLEDSLDWVKRLKPILKLVFKADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ35</accession>
    <name>A0A1Q5UJ35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ35"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8400" checksum="D806B24F452F1161" modified="2017-04-12" version="1">MANIFVRSTKDQADQFYQPADPNPGLPLGTQHLELVNLELLPGVNGLIVGTSCIYWGPQGLQAYTGSLANWPTSDIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJH5</accession>
    <name>A0A1Q5UJH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJH5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="51" mass="5779" checksum="7D24D58FF1DCABD4" modified="2017-04-12" version="1">MDDGDKAEKVNSLVGWLQRSMLFVSAWRYFSPFGPNDVDEGRAGNGCKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK76</accession>
    <name>A0A1Q5UK76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_1604</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK76"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="365"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="800" mass="86661" checksum="44A71BF87848570A" modified="2017-04-12" version="1">MAFQASIPRPNVAAVTSDLWPSMSSVLSAPFKRAAGSAPTAGVRDIRQHSSFAGQNVATFQRVSLPECLDTVSLEALRAGLVHRSAPRGLSPLLSADNALRALSTTSSARAFTSSTARSFSTLTPFRLSTLCTAPKINGLSRLQHQRFLFGGPSQNMLAQKEKTANNNPNSANAQNTFYQALLRANMPAIVVERYRSAQFASNAASEAIYAKALERVGSGETGGIAGANQNLNSDQLQAIGQAVAARSHGGQIGMANKPNGTGAKEAPLYVVVEESLGNTVFRWVKFLLIFGFFTYLSLVLITILVETTGVLKNIRGQQNNEAQPEKQTVRFTDVHGCDEAKDELQELVEFLLNPERFSSLGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFYMSGSEFDEVYVGVGAKRVRDLFTQARSKSPAIIFIDELDAIGAKRNERDAAYVKQTLNQLLTELDGFSQTSGVIIIGATNYPQLLDKALTRPGRFDRKVVVGLPDVRGRMDILRHHMKNVQISTDVDVGVIARGTPGFSGADLENLVNQAAIHASRDRKPKVGPLDFDWAKDKIMMGAEARSRIIQDKDKLLTAYHEAGHALVAYFSRSATPLYKITIVPRGMALGITHFLPEMDTVSRNYTEYLSDIDVAMGGKAAEEMIFGPDNVTSGISADIQQATETAFTLVTRFGYSKKLGNVDLSTNYDQLSSETKQEIEGEVRRLVEEARARATKILTEKRNELEILSKALIEYETLTKEEMEKVLRGEKLDKMAISPSAPIKLPDALQAAGLKPTPAADVPPTATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKT0</accession>
    <name>A0A1Q5UKT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-like protein subfamily C member 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKT0"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000110">
        <property type="entry name" value="DnaJ domain protein (AFU_orthologue AFUA_2G13210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="303" mass="34156" checksum="1F9A217E9312D372" modified="2017-04-12" version="1">MAKGAKTKNVVDEQPPSVEEDLYKILGVQSDATPEAIKTAYKKNALKHHPDKVSEDVREEAHKKFQQIALAYGVLSDERRRKIYDRTGNTDDVLGEDGDFDWLDFYREQLSAMLDTRAVSDFQKKYQGSDEEKRDLLEAYDQHEGDMDGIYESVMLSNVLDDDERFRAIINQAIADGEVEKYTKYSEESESKRQRRVKRAQKEAKEAEKLAKEVDNNKKKKAAAAAKASKATSGGGDDDLLALITKRQQQRGQGFLAQLEEKYGQPKGKKRGPMDEPSEEAFAAVGARKKSKDAKPKTKKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULS0</accession>
    <name>A0A1Q5ULS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 13">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_637</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 13"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULS0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULS0"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000027">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.110:FF:000003">
        <property type="entry name" value="Probable mannosyl-oligosaccharide glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013112692" description="Mannosyl-oligosaccharide glucosidase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="17">
        <location>
            <begin position="42"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="16">
        <location>
            <begin position="310"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="823" mass="93204" checksum="DEAC5B7FEA3C00B6" modified="2017-04-12" version="1">MHHLRISSLLTSLLYATGILASQDPNDVSVLIKEAARANNESLLWGPYKPNLYFGVRPRIANSLAAGLMWAKVDDFATVQQNFRHTCEQNEGMAGYGWDEYDIRKGGRETIHDAGNTLDLTIDFIKVPGGQHGGSWGFRVKGVPREDGSPDQPTSMVFYTTLEGLGQLGVDMDTVSESAPLEGDLRFNGYSSELGDFTIDVTDGPSSNEYFEIDRPNGEGKPLGHGLVSSATMPQQHLWQAKGILFAQMKGEVDEAIKELGPDNPPHPAQLFTIKHVPGDGNVHLVQKVFKGPFEFDVLFSSGSASKPVTSETITEELKDASLSFTERFKEVLAPKAPFDLDDEFSTFSKAMLSNLVGGVGFFHGDDVVDRSGHPAYDEENEGFWEETAEARASAQPVMEGAKDLFTCVPSRPFFPRGFLWDEGFHLMPVMEYDSDLALEIIKSWFHLMDEDGWIAREQILGQEARSKVPAEFTVQYPHYANPPTLFMALETFMDKAKSNQSVQSETLDKSDPAENLRSATLRNPELANGYLRSFYPLLKRHYSWYRSTQRGDIKSYDREAFSTKEGYRWRGRSVQHILTSGIDDYPRPQPPHPGELHVDLISWMGMMTRTLRRIAEYLGEEEDAEEFAYYETAITRNIDDLHWDEKEQTFCDATIDEYEESVHVCHKGYISIFPFLTGMLGPDSPRLKAVLDLINDPEELWSDYGIRSLSKKDQFYGTEENYWRSPVWMPINYLVLKNLYDTALVSGPHQEQAREMYSKLRKNLVENVFREWKSTGFAWEQYNPETGKGQRTQHFTGWTSLVVNVMAMPDLPETSQTSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM32</accession>
    <name>A0A1Q5UM32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM32"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="86"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="281" mass="30232" checksum="39EEBF7D88DBE1BB" modified="2017-04-12" version="1">MSEWFDKRRGLAFGIVWAGSGLSGVLIPLALEKFLGQYGFRTTLRIFSVLIFVLAAPFLYFHKSRLPVSREVKYDRLNARFLCSRVSIIYQLGNIAEALGFFLPAIYLPTLARTLGASDFLASLTVTALNLASVFGSVSMGFLSDRWHTLTCVSISTAGTVVSVFLIWGFATTIPVLMVFGVAYGLFAGGYSAIWSGMIREIQKDNPAADATIIFSTIAFGRGVGNVVSGPFSEALIQADCWQGHAMGAYGSGFGLLIVCTGLSAVLGGLSLISHFSRCMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMV5</accession>
    <name>A0A1Q5UMV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMV5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9617" checksum="2A9031A94BD7494C" modified="2017-04-12" version="1">MACTMWLPRACHANQSSAKGFPDQQDHLDYLRLASVCCSKLPVKLSASALTGVKHDALKAQRLWDPDHSFFNHSVWSNKNGDVLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMW1</accession>
    <name>A0A1Q5UMW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disulfide-bond oxidoreductase YfcG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMW1"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="252" mass="28707" checksum="8197D3C6844D4323" modified="2017-04-12" version="1">MSQPNITLYTTQTPNGIKISIALEELGLPYKVEKIDISKNTQKEDWFLEINPNGRIPALTDTFSDGQTIRLFESGGILQYLAERYDTEYKISYPKGTREYYETNNWLFFQNAGVGPMQGQANHFVRYAPERIEYGVNRYVNETRRLYGVLDKHLAKSKSGYLVGDHVTIADISHWGWVAAAGWAGIDIEEFPHVKAWEELMASRPGLEKGRHVPNPHTIKELMKDKEAVEKSAAQTRAWVQAGMKDDAKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN97</accession>
    <name>A0A1Q5UN97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neutral protease 2</fullName>
            <ecNumber evidence="14">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_357</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="14"/>
    <dbReference type="EMBL" id="MNBE01000121">
        <property type="protein sequence ID" value="OKP13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN97"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011827697" description="Neutral protease 2" evidence="14">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="180"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="37593" checksum="D9E6224AE72ACE50" modified="2017-04-12" version="1">MRFTVFSAAVLAFAQHAYALPVEAEQASGLDVTLSQVSDTRIKAVVKNTGNEDVTFVHLNFFRDSAPVKKVAVYKDDDEVTFEGIKRRFKLQGLTSEALTTLAAGETLEDEFDIAATSDLSHGGPVVLRSSGLVPLVNEGAVSGYLPYHSNDLKIEVDAVKASRVNKAVKPLNRRTQESCSNSSRKSALERALRNAASLATAAAKAAQSGSASKFSEYFHTTDSSTRQLVAARLQAVAREAQSTTSGGTKYYCTDVLGYCETNVLAYTLPSQNVIANCDIYYSELPALASSCHSQDQATTSLHEFTHAPAVYSPGTDDLGYGYSAATALSTSDAIMNADTYALYANAINLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNF2</accession>
    <name>A0A1Q5UNF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_262</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNF2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNF2"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="63"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP13993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="458" mass="49745" checksum="83DF308CBC98A1B2" modified="2017-04-12" version="1">MVQISEVKGNSRENRTAAHTHIKGLGLRSDGTSEVTGDGFVGQAAAREACGVVVDLIKAKKMAGRAVLLAGGPGTGKTALALAVSQELGTKVPFCPIVGSEIYSAEVKKTEALMENFRRAIGLRVRETKEVYEGEVTELTPEETENPLGGYGRTISHLIIGLKSAKGTKKLRLDPSIYEAIQKERVTVGDVVYIEANTGACKRVGRSDAYATEFDLEAEEYVPVPKGEVHKKKEIVQDVTLHDLDMANARPQGGQDVMSMMGQLMKPKKTEITEKLRQEINKVVNRYIDQGVAELVPGVLFIDEVHMLDIECFTYLNRALESTISPIVILASNRGHTVIRGTDDISAAHGIPPDLLARLLIIPTTPYSSDEIKTIIRLRAKTEGLNITEPALDKVSEHGSKVSLRYALQLLTPASILARVNGHPGGIEVADVAECEDLFLDAKRSAMIVNQDSSKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNX2</accession>
    <name>A0A1Q5UNX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_164</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNX2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNX2"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="99"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="546"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP14170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="666" mass="74022" checksum="D3A47A2F9881FE2D" modified="2017-04-12" version="1">MSDASKPSVVLEAHEVDTFHVPKAFHDKHPTGTHLKDLDEYQKLYDESIKSPDTFWARMARELLTFDRDFQTTHFGSFENGDNAWFVEGQLNASYNCVDRHALKNPDKVAIIYEADEPNEGRTITYGELLREVSRVAWVLKQRGVKKGDTVAIYLPMIPEAVIAFLACSRIGAVHSVVFAGFSSDSLRDRVIDAQSKVVITTDEGKRGGKVIGTKRIVDEALKQCPDVTTCLVYKRTGTEVPWTTGRDLWWHEEVEKYPNYLAPEPMNSEDPLFLLYTSGSTGKPKGVMHTTAGYLLGAAMTGKYVFDIHEDDRYFCGGDVGWITGHTYVVYAPLLLGCATVVFESTPAYPNFSRYWDVIDKYDVTQFYVAPTALRLLKRAGDEHIHHKMKSLRILGSVGEPIAAEVWKWYFESVGKEEAHICDTYWQTETGSNVITPLGGITPTKPGSASLPFFGIEPAIIDPVSGEEITGNDVEGVLAFKQPWPSMARTVWGAHKRYMDTYLNVYKGYYFTGDGAGRDHDGYYWIRGRVDDVVNVSGHRLSTAEIEAALIEHPMVAEAAVVGIADELTGQAVNAFVALKDGNETTDQVRKDLVMQVRKSIGPFAAPKAVFVIDDLPKTRSGKIMRRILRKILSGEEDSLGDTSTLSEPGVVDKIIATVHAARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPL5</accession>
    <name>A0A1Q5UPL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_14037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPL5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="117"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="482" mass="56372" checksum="E893026F1696C7A0" modified="2017-04-12" version="1">MNWNWNMRYWTPEYWKGAFCFTARDLVNPQSELAQRYPHLYQVFRHRLESAYAARDNRPVSLCSHTRLPHGYKGFRSDTDSFQKKNELFGFCDSSERGKNAARNRMNNMCSEITDQMDVYGTAGQGSFGSVFLARERSDSNNQNNPENLKHYAVKVQQHNTLLGAENTGHRGPPNGPVPDNRKSLRYVPEEALIMLFLTDSDRFPTLDAVYTHDRYQAIVMSPCIDYNTERQPSPPKDHSRRFPALTARYLLTKDHKPLLNPTEGGKVATQLFQAMRQLADMNAWHNDISVNNILVDENLNAQMIDLGDFGFALEERDFFERHYMYVPFQEYQLSPELAQYISNQVGSAVNFEVPHDARQESMWKFATMIYGILHGFWPWNEAPKDGGRHPDLLNHRVYTDPRHLLDRRHRILNAPLPIDENLPQDCKDVLQALFSKNPEDRPTLAELEGYPWFSQWARETQYFERPFSRDFQKVCSRRKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPW2</accession>
    <name>A0A1Q5UPW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Versicolorin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000087">
        <property type="protein sequence ID" value="OKP14511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPW2"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30049" checksum="450C426AC4D6D6F9" modified="2017-04-12" version="1">MSLSGLVVVVVGASKGIGKEIALRAGADGAKVVINYMSDTKAATAIVAQLGHERAIAVQADVSNSTEVDGLIQVTVAKFGRIDILIPNAAYVPEKDLRNVTEEDFDRAFAVNVKGPCFLAKVGSPKSFRFASRNTFSGSVLWQLPFESEIMLTTFQKALPHMTPGSKIIFISTDMTDASVIQPQFLLYVSTKGAMNQMVKVLARDLASSGIRVNAISPGATSTDSFHRVVDESKERILASHNPFNRIAHAEEIAAGVSLLWGKDSDWISGQVLKVNGGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQT9</accession>
    <name>A0A1Q5UQT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQT9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQT9"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="345" mass="37145" checksum="04AFBBC9F31FA8AB" modified="2017-04-12" version="1">MGQQGRDRRGGGGRGQGQSRDVQVSKALSLLLRHAAEKEGVKMNAQGYANVADVLEWRKLKSIKATFDEIKHAVDSSDKKRFALLHIPSAQPTKSTTKATTIPTTIPGSEEQTDGEISAGGDQPATSVLEAPSSNEDQANATQQALASTDTEPSNYMIRATQGHTIKTVDAASFLEPLTLADESKLPDTVVHGTFHGAWPLIQQSGGLRAMGRHHVHFATGPSLESAMASSETTSQEKANAKPETQVISGMRRDAQILIYLDIKKALAAGCPFWRSENGVILSEGLPVSDGKTDADGNPVKVVSIDFFDVVVERKIGLGKIWERGEVVKELPEYAIKKGTPKNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQV6</accession>
    <name>A0A1Q5UQV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQV6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQV6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="281" mass="30721" checksum="DC1B137B9B2C4140" modified="2017-04-12" version="1" fragment="single">MVAPGLGTYANPIVIGDDLAPLGSASNPIVIQVDEGWCQDEPDQLGSDADTEIMATPEFWGTLTAGHLAVPVKDDVALDSSSVRVPTRSLVCEDPEGFQPFGRSSPNGFQSEKALKITKHSFDALRECPGFGATRRENVASDHRENTLPSNSNRSKQLQGQSEEGRVTMRFYAPDFQKGATWPTNLLVNQVIIRTAFSPDIPCSLEIFKQDDILFGRGAVVVPMEGKDPKCFLTFSPKARQDDHGTNVRASRKRADGIVILESVVPEREKGANWRYGFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR13</accession>
    <name>A0A1Q5UR13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="13" type="ORF">PENSUB_5073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR13"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="178" mass="20726" checksum="B662A91C580C53C0" modified="2017-04-12" version="1">MKAYWYDNKPGDQREPHDSGRTVSEEKLASLGVLYHHCPTIEAVDAIAKARGYKNRDQVCVSPQAMGDIYEDKVKMFFAEHLHEDEEIRYILDGEGYFDVRGQEDEWIRIDLVKDDLIILPAGIYHRFTTDEQNYVKAMRLFQDEPKWTPLNRVAELDVNPHRKNYVETVLKPTAAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URS8</accession>
    <name>A0A1Q5URS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitosis inhibitor protein kinase wee1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URS8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URS8"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14052">
        <property type="entry name" value="PTKc_Wee1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000536">
        <property type="entry name" value="Cyclin-dependent kinase WEE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="710"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1083" mass="117987" checksum="3F3A144A0C816AC7" modified="2017-04-12" version="1">MVATFSPHRDSGGTLHLSSHSPLHHVDASSAIRQLRRSLSRSPSKSSNFFLNSRTHSPSKSTTFISSPLSPSRRSSHNNFVLFPSTGQQSPLAVPYPPSAKITRPVMRRRTSPRSPAKCALTVSADGGNSVSSQPIPIIAPGEENALTLDDLADPSESNSCATPCLSTTPTAPLGESTFGPRPTLSRIEKRRSGTFGSFATVSPLKRSDGIMNLDQASRGSPSAKRRSVHASNFAADFSIFDHESETAPASPAGNGDEATSYFPTPQPHNPFATIPKRSSSLRRSTLQQRQVERPLFGPRRGLGETEASPGTPLAVRPRMSFDSGLFQSSQESSSLFSPRPPPASPLFSPAPPAINTNTSNFGTTQPSRPSAHPLSRTITQSSSGSSLEDSPTHEHVQKPERALRPFMNFSKSLPAGATRPAPVRRVTREETSSTESFATPENYKLVKPLPAAFMSTGLISKKNRNAEEVHGGGFNKNMPDTPCKRPVNMFTAGADSPLPESSFFNKSQFGRQLEAVSASPFNPPASSARPKAGPFARGMGIFGNSFTRPELSRRGSVVSVDGEDMLQAQSPSSRDDSQPMTDSDLPPTPTKQTFLPSRTYPPATSQIASLERLSESRGSTHSTPLRDRFLQASTTPRTPRDQFFPPDPSGLSISAPNDQQPPQLDFGSSLNLPATPTQPRESFLSSKGASLLLSGYQAPDVDSSLTSRFAKVELIGTGEFSQVFRVAEPHDTAYSSVFSFPTGERQSPTKLAHQVWAVKKSKQPYTGLKDRERRIREVDILKALVSSDHVVNFLDSWEVKGHLYIQTEFCEEGSLDVFLARAGLKARVDDFRIWKILLELALGLKHIHDNDFIHLDLKPANVLVTFEGVLKIADFGMATRWPAEQGFEGEGDREYIGPEILMGQFDKPADIFSLGLIMFEIAGNVELPDNGLSWQKLRNGDMSDVPSLTWSSETSIFRDASGNPISEESSFEELCASDLGDHDFDGFLSVPKAHKPSRAARSGELVHPPDFMIDARHDQALDKIVGWMISPKPQDRPTADQILETYGVQFVNRRRRAGATVFEGNWGPADEMLAEDAEMIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URX3</accession>
    <name>A0A1Q5URX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inorganic phosphate transporter PHO84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URX3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URX3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="575" mass="63658" checksum="E3AB18034B299D2F" modified="2017-04-12" version="1">MRQIYETIDRQGYQWIVVLVAGLGFFLDGYTLFASNMALPMISYVYWRDEISSLRLTCINIATLAGTLFGMVIFGFLADKNGRKKMYGVELVLLITSTLGVVMSSTGENGSMNIYAWLIWWRICVGIGVGADYPLSAVITSEFAPTKHRARMMASVFFMQPLGQIAGNLVSLIVIAIARSKGSDDLTRTVDIMWRWVLGIGVVPGAIACLFRFAIPESPRYLVEIEDDPVTAQFDATTLFSDQASSPAFDQTSFATGTGSAIQLPPISSLASDSIDEDEEYSSHMPPATLNSHWRLARTDIIRYFWTEGNWRSLAGTAFAWLLLDFGYYGIGLSSPQFLAKTWGSLHLSHPAPNWETDDRPGASVYDQLFNTSVHGLVILNIGSFVGGLIFILFSHRIDRVALQKYMFVALAALFIALGSMFINLYTYPPAVVTLYIVGQILFNFGPNATTYMIPAEIFPTRYRGTCHGISAGAGKLGSILVQIFSTYYRFSGADTISTRRHGIILFVFSACMILGAAVTQFWIPPLQQKKGSNLIWGGKPYTLETLSLGRMGRKSRENNLRKRASRQRAMSFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMN0</accession>
    <name>A0A1Q5SMN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylosidase/arabinosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMN0"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18619">
        <property type="entry name" value="GH43_CoXyl43_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF5">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO89230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="37437" checksum="7F990381FD7F6B3F" modified="2017-04-12" version="1">MAAPKPLITHLYTADPSAHVFNGKLYIYPSHDRETDIQFNDNGDQYDMTDYHVFSMDSIDGPVADSGVVLSAKDVPWVSKQMWAPDAATKNGKYYLVFPARDQEGIFRIGVAVSDSPTGPFAPEKNYIPGSYSIDPAVFVDEDEKPYLYFGGLWGGQLQCWEKSGSEVKEGDKMNGLVFNASKSGPQEPSGAGVPALCPRVGQLSDDMLTFVSPPQELQILAPETGEPIAADDHERRFFEAAWMHRYNGQYYFSYSTGDSHYLVYATGSSPMGPFTYQGRILEPVLGWTTHHSIVEFKGKWYLFYHDCELSGGVDHLRSVKVREIVYDAEGKIHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNP6</accession>
    <name>A0A1Q5SNP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNP6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNP6"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO89624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="162" mass="17908" checksum="586CD6E91F4394D4" modified="2017-04-12" version="1">MSLIDTDHHFVPEFYAQAVEEAGGDPSGWPTPSWSSEGATAFMDKNGITKAILSLVAPGAVIAPTTEKRRVLARKANEFAAARRDEDPNRWGFFSTLPCLLDTEGALAEIEYALDVLKAEGVTLFTRYGEGNQYLGHPDFKPIWEEIELEKGRGVYSPYPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNZ2</accession>
    <name>A0A1Q5SNZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Serine/threonine-protein kinase bur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13784</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="548" mass="60155" checksum="1D5ACE5B53B154EA" modified="2017-04-12" version="1">MSIASLEKDGRGDPRFPGCSNIRDFEFIGKLGEGTFGEVYKARSKKDNSTVALKKILMHHEKEGVSGLLCLHYHPAVIDPHLSQFPITAIREIKLLKALSHVNILQLKEMAVERNKGKIKLCEGRKKPSMYMVTPYMEHDLSGLLENPAVHFTEPQIKCYLYQLLEGLRYLHANQILHRDMKAANLLISNGGILQIADFGLARPFDEPPPQAGKGGGEAKREYTALVVTRWYRPPELLLQLRRYTSAIDMWGVGCVFGEMFKGKPILSGNSDLNQTQLIFSLVGTPTEENMPGWSSLPGCDGVKSFGHKPGNLSQVFKDQSPVAVSLLTELLKLDWRKRINAIDALKHPYFTTPPLPAKPGEIPHYQDSHELDRKKFRDQRAPQPPAPAMGSTDPPSNGGWTGPGSRPDSRNSNSRIPGAARGGRPNGPPGVPHRRGPFPPQRESGLPPRPPLSTAPPPWEGSQSGRSDGRDDQRRDRFNQGPPGGRPGATGRIVGEILGEILGITILSLIKIGVGDSDGITAVNRLGEEAGVLVTETETQPEDEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQR1</accession>
    <name>A0A1Q5SQR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQR1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO90338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55062" checksum="61088BCE20EE3CCD" modified="2017-04-12" version="1">MATDAQQEHVCASCLKAYQRHDLLLRHRRRCRGLKRPPTRQKACNACVQAKAKCSYLQPCMRCAGRGISCTYASLSLSHGEYQSVLIDQEGRQDAHQTNYPDTFLEDAHDPEWLVDHVTGDLPSFQLSPSLARTPNFMDAGQPPNARHPMQGVFADIVSDPAAVEPSAFLDSLTIPRLADLSSPESSIQYPLRDLIRVLEQYPRNLLRDDFTPPSLHRSLYDENVPDIATLARTSMAVCCGSAMETAEGARFAKHAMEVERQRLIASYRTYSCMHQWDALHAMLVYSVLELRASLAEGNDGWKQKSCSKGLKAPFLVKMTRDFIRSHTVPEENLTAQAYTPVQSFQQWATTETARRTIFLANIVHFLSNHDPETGEPSPYYEPLDDELVLSMPLPSAHTMWAARTEQEWRQAMKSLETASSPDGEYPSSEVHPAQKGLTLGYYLSEYPHETLHNYLKYHCGLGSTDELRSFIVLCALKQFDHIQPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZB9</accession>
    <name>A0A1Q5SZB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZB9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="419" mass="45210" checksum="3362C4C63E9B2B25" modified="2017-04-12" version="1">MAEERGSSYKPYLQDSSSTGDSSSEDVSSTDLRVQETHILQERKIGVFGAISLIVNKIIGAGITGYGATTDRASNWNIETSASNAITASSYLLKAADADSTTWKLRGLAIAAVGFAVGVHSITPRIGRGLQDILSAVKLFTLFFIVCTGFAALGGHVKGAKPHNFDISTSFEGTSNNGYNIGTALLNAIFSFQGYDNMNAVLSEVKNPQRTLRIALPTAMGTVTVLYILANIAYRYLTARVLQELAKDGITPFPNLLMQNRPFKTPIACLAIHLAITIIFICAPPAGDAFNFVVGLGTYPTVFLLTLVTIGLIKLRLDKNDKFQSSFKVPWAILAFYLAGNIGQFLLVMPFVPPVNGKGSTSLPYWLSPVVSLAILALGVIYYVGRFILLPWAFGYELDLVAVGLSDGSRVSRYKVRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2F6</accession>
    <name>A0A1Q5T2F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gibberellin 2-beta-dioxygenase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2F6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2F6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="122"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="277" mass="31849" checksum="9E7B86E058B8F38B" modified="2017-04-12" version="1">MTVTQLPLVDFGQFLHGNADQRQQAAKKLVDSFVNHGFVRLKNHGISRDFVQQIWEWEHFDCGPRGDTEFPNKFPSEEDLPGFKAFIEQYFDLVQDVSLDIMRACEVGFKMPENSLVDRCIPAASELRLLHYPPVSLERLQTGTIKRAWPHTDFGIITLLFQDSLGGLEFEDRNKPFTFVPIIPSDDNELIVNTSQTFQRWTNGVVKAGLHQVNVPPHMSTITEGYIPERYSSVFFLKAHREISVGPIEQFVTEERPAIYPDITALQYQQEMTEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2G5</accession>
    <name>A0A1Q5T2G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lovastatin diketide synthase LovF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T2G5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="930"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="930"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO94430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1971" mass="214816" checksum="037CF1A55CA16A0E" modified="2017-04-12" version="1">MNGTAEPNGAPCNGEPQIPQPIAIIGYACRLSGQVSSPGDLWELCTRARSGWVPIPKDRFSHGAYHHPNPSKPGTLNPAGGYFLDEDVSRFDAPFFNVTVQEAISMDPQQRMLLECSYEALESAGIPKESLAGRDVGVFVGGNFSDYELNNCRDIETVPPFQATGNANAMQSNRISYYFDLAGPSMTFDTACSSSLVALHYAVQSLRSGESKEALVGGCRLNLLPDFFVSMSMSQLFNDEGKTYAFDERAKSGFARGEGAGVVLLKPLDAAIRDKDPIRAVIANSGVNQDGRTKGITLPNEHAQEQLIRRVYREAHLNPEDCGFAEMHGTGTKAGDPIEARAVHAALGGGRTARNPLYIGSVKSNIGHLEGASGIASIIKTAMILDKGLLLPNADFKKPNPNIPLTEWNMKVVTSTRPFPRGKKYASVSNYGFGGTNAHVVLQRPPPPDRAEDDAGVEGDPKSRLFLISANDKESLRTRIQDFGIYFEQRPEVFENSLFGNFAHTLGTKLSHLSYRVALSASSLDELGVKMAQLKANPIRVLGTPTVAFVFTGQGAQWAQMGIPLMGEYPVFSKAIERADKCLRDLGAEFSLVEELQKEAAVSDINSPHLSQPACTALQIALTDLLRSWGIQPSSVVGHSSGEIGAAYAAGIFDLEGAMALAYRRGQMTSLLKSSYPLLKGTMIAVGASSDAIKPMLKTMRGYATVACVNSPSSVTVSGDADAIDELETVLQQRQLFNRKLKIDVAYHSDHMKKVAEAYLSAIGSILPSSSATATFFSSVTGEIAEPSDLAPSYWVANLTSPVLFANALAKMCNDVEKRPNLLLELGPHSALKGPILDTLKSLGSFASKISYAPTVLRNADPAQSMLDAAGAVYVRGGSLNITEVNFPVSGARNRSFLRDLPKYPWQHGTRYWHESRIADVHRFRDGKRNDVLGTLAMYSNDLEPTWRNIVRLDDVPWLREHKMQGMSVYPMAGYLAMAIEAARRRAESHENPFSQFEFREVTVGAALVLTDDVDAETIISLKPYAEGTRGNSDIWDEFRISSWTTKRGWTVHCSGMIRTRSNQKQQTSVSNIVETEGKYFRGQIDRVMEQATYKIDIHNMYQVLTDIGAGYGPCFQGLENVFSSPHYSRGDLYVRDTKSVMPKNFEAPLTIHPTFLDALLHLTWPILGQGRMELETLYMPTMLKSLMICDQIPSTPGASVKAWCNGGPCQANAEPTKFDLWVTTEDSTEVLINIEGLVMTPLKDAGAISGENVRGLCYKFEWKSLAELEQETAAKSQEPNGHFNSMNGHANEPNGGLTNGDVLNGLTNGHLSPDEKPHINGNGIQNGCHLTDIVITQFGKSDGIADKLNDAIQNQSNDWKPSISSFDEIDATGKHVVVLQTGARSLRNLTTESFEDIKKTLLNASNILWVYRLDNPDAQMIVGLTRSLRAETLAKAATLGLETEDLENPATPIMAAVTSLWSVDNPKPCEDFEFRAKGAELFVPRALTNQAADVFVHNETHELTISSQPFQQPGRRFKLQIGNLGALDTLYFADDVVELLADDDIEIEVKATGLNFKDIVVTMGQLAQPYIGIECSGIVSSVGKNVQHLQVGQRVMALPLGGYSTYARCKATSAAPIPENMSFEVGATVPVVFCTAYYALFDLGHLQEGERILIHAGAGGVGQAAIMLAQMIGAEIFVSVGSVEKKQFLMTQYGIPEDHILYSRDTSFGRGIRRATNNEGVDVVINSLAGDLLRETWECLAPFGRFVEIGKADITRNTRLDMLPFEYNVSFASVDLTKVALHRPKLMKRLLENVTELMAKESVRPILPLTTYRISELETAFRTLQTGKAMGKIVVVPHQDDYVKAVAPKTGSSLLKADASYILIGGTGGLGRSMARWMSSKGARHIVLVSRSASVNEQVQALINELAVDGTHVVVKPCDVSSKPSVENLVKEEMKDLPPVRGVVHGAMVLRVCPANMPTTQTSVQPANTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2H8</accession>
    <name>A0A1Q5T2H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_11714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2H8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2H8"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="292"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO94447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="42855" checksum="E94A2E47BB956289" modified="2017-04-12" version="1">MASPIPRGLKQVLQKTPNDIVILSSLRTPVTRAKKGGFKDAYPEELLSHVLRATLKANPNLDPAMIEEVTIGSVLQELGGAKAGRMAQIHAGFPHSVPFNTINRQCSSGLAAITAVSYGIRAGAINVGVGGGMESMTRNYGSRAIPTVLWPELKDSPSKDARDCIMPMGITSENVASRYGISRADQDAFAAASHHKASAAQKAGRFDSEIVPVTTKSYSAENPDAAPEEITVSQDDGIRHNISVEKMASLKPAFAADGASTAGNSSQVSDGAAAALLMRRSTAEELGLSGSIKARWVATAVAGCAPDEMGVGPAVAIPKLLANTGLSVADVGVWEINEAFASQALYSIRKVGIDEAKVNPNGGAIAIGHPLGATGARQLADLLPELERSGQDIGVVSMCIGTGMGMAGMFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2S5</accession>
    <name>A0A1Q5T2S5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2S5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2S5"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="951" mass="106299" checksum="4253A5BFC5F023C3" modified="2017-04-12" version="1">MASPADFSIVPPPASYPTETYKNYKVFPDFVEEAMDKILSEEARLEESRSNDWPFYSGADGSGDSPASYKLRNGAADKKDSPLSTPRVMTKSRAKKTTKSTKPKKKRSAAKREITVIDLRSDDESPLPKDTDIDHDKHDELQDPQDPQDPQERNVDVNSQAVATIEGDSDDTSEIFDAMESGVGTVNVNIINPKTVHVNIVNAKTVESGPMHVKNIEANVAAGDRICVSENGVRNSGEDFKEEQLIFSSVTESVKGHVLHFIVAHPFMSQFVQPVKRSARRQFITDMCKEALSKGVDPGVIWDLIKYVRRLYLDRAGVRAEPLAPGLEDIPFGEEVDDEPESHSPSRKSRKRSRKEGSPSPKNKRSKRHLLESQKAPQPVTVSEVIEIADDANPPSPELPNSPSYTKDEQTTVFQVQSTPDSPLNAIVTDGDEFPNGVVENHFLESTPELPSHLLDVQAQENHERTTNVQVESTPDLPLETGDATVSQTADTLPTEDLIQPSVPIERTISADDKKEGLKDAQEASNLPRARDSANDEVVPEGLRKPEIPPETAADRMPEYLNPIMALEQNKNHPDNLSKSQKRKARRQQLNKAPQEERTTETKDNIQPTPPLQKLVACGVGDAAHKTSEAGTSVNVECSPGNLDVSNDLPEAVANLIQENLFPDLPSVPTSKATTKLSKNQKRQERKKAKREKKAKKNQERREKELKAQQQPTNSWLKHRNILHLQDTPAQALQTKKNQAHVPLSKPLAIDPEPRKERKRKEREHKREQKRERKRKRESSKLETNSNTIDDGQNQDDLLAIEAPELGEQELKKQAKKERKKERKRQERSLASHHDEGDVKDDEATPDIPFLDRSNESHELSNDRGEDVVSSDHDEPKARVYIARETPRPENTVAKKSFSPSSTQPQTPVKSTPQREVAGVESMLISTPSSSASRSRYGPLSPDPREWDTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T355</accession>
    <name>A0A1Q5T355_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000716">
        <property type="protein sequence ID" value="OKO94683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T355"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T355"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="12033" checksum="9606FF7F1F89727C" modified="2017-04-12" version="1">MWNAPSVHSVFGTATTGSSEAVLLAGLALKHCWQFKHHNLPQARMNVIIGGNAHICVKKFADYFDVEARVVPVNEQTRFAFDADGLKERLDENTSMFIYQKPPKVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4C2</accession>
    <name>A0A1Q5T4C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Saponin hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4C2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4C2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841060" description="Saponin hydrolase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="67209" checksum="C9AF87E87FBFD20D" modified="2017-04-12" version="1">MSNMRWTFSAIAGTLALAMASTIPATPQPEPIDVVELPLPPVAPSNSTGACTASINPHRTGCIGQISESFQAGDFAPDGKHVVVNVEFVGAPAAPDPASIYVGEHIILVKADGTKFPNGDPWKCLSCGVLSQRARGLDPQRDYPHVARNSRQALWGHNILDCSGIPLASDECTPNKTHIYPIYWPTGTNKSGSPREMRLHPDGIHMGWSSFTTGGQFAYYGQLQFRQNPTDGTLLVPRYDLVNVNLLVHPNGTAPIMAQGTELKIHDEAITVGELRGFSGSGDEILYIGSTREANNIDLFAVHIITGAVRRLTSHPEYADPIAFSHDNQWFVTMDTRGSNRQMWMAGERYIPPLIDLVTVTAASSTRNNGARRFFQPILIDRYGDRGDYFGQQVNYAGDGSNGSVNDPNWNGRADPAFSPDGTRIVYWQTLVTSPACGGVNPLPCPVSTAQGGRTYRLMLARLSSRKPTTPAPIFTAPDYIPWATSFPPNSTLPTSYSLPAGNYTLYGKASGLAKASLTRDPLFGSFKTVSVNYTNYSDDAQHFINGYESVTLTLTASNPWLSQLDWVSDIAQTGAVNAVKKTGPDGFHLTIDAMDNIFEANGTLTTTVNGVTYYQPLNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4P9</accession>
    <name>A0A1Q5T4P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4P9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4P9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57995" checksum="871CEEF5C5D45636" modified="2017-04-12" version="1">MPLTFRTEIESTYYHKEIDNRADSCNSYNACTTISAYESKQWHLKHHGLILQNLGSFMILPLTHSIEAEAMCFFMDISIKHLNEYRPCEPWRKTLMFFSQTVPSVRHAAIALALIHRNYLDRHSNSRVYQPPFMKDRLPDKAPLFHYNRAIQLLLNLERGGSAKIIAVTLLVCYLFTCFDHLAGDDVQAVKHLRGGVALSCNIGSTTLNNCTYDDAQSSGVHAIICQVTKQICRLDMQAVMFLVDWTPAHIQETFISQLALVNSTFWSVDQAADHLQILVAQVIRLHNTEQQMSPISTMAPLSSPPKDIVLGQLEKWSSLFEYLVQQTSPSGPDFRTDPLVSLLRLQHTIAWTLLSGYGPGREMDYDNFLPQFQQCVALAGEVAAAHQRYSGSSRSTFTPEIGFIPALYIIGVKCRHPTVRREVLSILRRQPIREATWDSISTAIIVERVIEIEEGTAGGEQMVQFMEQIPVWQRIEALSYIHIPGGQSAARLDITYTFCAQEGIHVESLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5S2</accession>
    <name>A0A1Q5T5S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5S2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="76" mass="8376" checksum="071F48AA945F3BA9" modified="2017-04-12" version="1">MPSWSYTDPGPFSPTNGWQPTYFLPTSTAEIHPAESYCVHTAASCMTEPSIPDLSSFRRTSGTSSTMSLKMRERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5X1</accession>
    <name>A0A1Q5T5X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional purine biosynthesis protein ADE17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_11122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5X1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5X1"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO95610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="593" mass="64876" checksum="7463D73B86943601" modified="2017-04-12" version="1">MSQKSAIVSVYDKTGLLDLAKGLVKQNVRLLASGGTAKMIREAGFPVEDVSAITNAPEMLGGRVKTLHPAVHGGILARNIESDEKDLAEQKISKVDFVVCNLYPFKETVAKVNVTIDEAVEEIDIGGVTLLRAAAKNHKRVTILSDPTDYPEFLKELEAGDITEASRKQYALKAFEQTADYDTAISGFFRKEYAGNGLSQLSLRYGTNPHQKPASAFMVQGKLPFKVLNGAPGYVNLLDALNAWPLVKELKQALGYPAAASFKHVSPAGAAIGVPLNEKERKVYMVDDIKGIESSPLAQAYARARGADRMSSFGDILALSDIVDTPTAKIISREVSDGVIAAGYEPEALEILSKKKGGKYLVLQMDENYNPAPEESRTLYGVQLSQHRNDVVITPNKTFNNVITPKGASLPEAALRDLTVATIALKYTQSNSVCYALNGQVIGLGAGQQSRIHCTRLAGDKADNWWMRFHDRVINIKWKQGTKRADKSNAIDLLCSGQTPRNDAEKVEYERVFEEVPAPFTQEEREAWLQKLGEVAISSDAFFPFIDNVFRAARSGVKYIAAPTGSQNDAPVFETAEKLGITFVEQAVRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y3</accession>
    <name>A0A1Q5T6Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_10959</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y3"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO95938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="157" mass="18293" checksum="9079921F6499237B" modified="2017-04-12" version="1">MTLCLNRLQEERKQWRRDHPFGFVAKPQRTPQATLDLKRWECAIPGKKDTLWEGCVLKLELIFPDEYPTKPPKCKFTPPLFHPNVYPSGTVCLSILNEEEAWRPAITIKQILLGIQDLLNDPNPESPAQADAYNLFKKDRPAYERRVRQVVRDNPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8T4</accession>
    <name>A0A1Q5T8T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8T4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8T4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="605"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109548" checksum="231E6A1175C39F0E" modified="2017-04-12" version="1">MPPLSAYTPFESLLFFQSLATSDVRPASFASISTLLSNNPLVRQNVAFSADRLSPEALEDLYATLLRDGFGRDGTSLGPDGRSTESSGPSNPKKRKISSPRPDGLTEGLSHAVLVPELVAHLYARYKELVTKEIRDDEKRFTDIKIEIERLQREDVKTAVPTAKGVPQATKLERRDSMDISVKQETPRQERPDQTIPLATQAQPVQSIPQAVQPEPGQPTEVPRPPGAPVGSPGAQPPQLQAQPTPTKAGQPLHPQAFNRQDVPHPPLQPPFAPRNQQPGPSTPAAARVAPPHPSQVAPRPNVPVGTPVAPGKASIPISTSQQPAPTQSSFQQWQLEAPPHSPYSATSPATTTPHLGLAPGKPPVPPSQVPSRTQSKASISSAVPSTPGAASPAAQTPVPVGYPRISQTPSVLIPAYPESRGSRPRLSIDTPGSSTPWKRTPRLSIPESPVSPARPRPEDVSPISERAPSPDAMDISPPREKKTTRRSQATTVESKATPSIKVEKGTSTRRKRAISSASTQSRGRSVASRDDSPDPSRAATLRKGPAAIVDDQTPKARSKRKRGVSESFDHEPILPEQPKIDTTRYVLCARGFHRTAAPIMNDVTTHKLASIFAKPLGERDAPGYHDLIYRPQDLKSIKSAVHQGSKAVAAATEAVSTPAGDGESPVPAAGTPSKNNMLMLQKTEELIPPKGIVNSAQLEKELIRMFANAIMFNPVPARGFGPAFPMMNERGSRESTQSGDGDEGGIIQDSIEMFEDVEQAVTHWRQAERTAERNADDLANKNVLALRRGSVSDFNTDSADDCDESKPRCRDCVRRDEICSFETSTSKSESPQSGSQRVEQQQHPPPSQYPLQTEQVQQLPEEAHYTPKCLLDLRLMHHYSVFAAQALSNTLDENVVNALKVDIPCVAFEHEFLMHAVLLVAMVHLCCVDNSAEHLPIFIYRDQALRALRHAVTHLSSGNIDALRGASVLLAAVSFPTDRWTNQSGLWVTNWKALALGQRKLHPARFGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9F2</accession>
    <name>A0A1Q5T9F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">penicillopepsin</fullName>
            <ecNumber evidence="6">3.4.23.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_10428</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.</text>
            <dbReference type="EC" id="3.4.23.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.20" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9F2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9F2"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012050174" description="penicillopepsin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="18">
        <location>
            <begin position="109"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO96874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="427" mass="45505" checksum="8796BC5F39E2E161" modified="2017-04-12" version="1">MHLILSLLLFLALSFDVLAAPAPRPVRKSRSFQIDRVKRSDYVPHGPTALRKAFRKFGITPVDFTNITLNDFEPFDLKTSVVKTNQNTINEPDQTGAVSATSVQSDVEFVSPVTIGGQTITMDFDTGSADMWVFNSELPSSMTQNRTVYDPTKSSTYKKVDGGTFNISYGDSSSASGGLAQDTVDIGGATVTSQTFGLPTTVSSSFVEDTNSNGLVGLGFSSINTFSPGPQKTFFDNIAQDLEEPVLTARLRSDGVGEYEFGKIDSTKYTGSLVNVSVDSSAGFWQFEAGYFAVGSGSLQKVTQVPKAIADTGTSLMLVSPEVVTAYYKEVKNAAYSSGVSGWIYPCSAELPSLTVALGDKYQATIPGSLVSFAEVGKNTTTGETVCYGGIQSNQGSSLQIFGDVFLKALFVVFDQRGPSLGFASPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAG4</accession>
    <name>A0A1Q5TAG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="549" mass="60841" checksum="9B71621A798CE493" modified="2017-04-12" version="1">MSDKIPSWNIVHKLEKRQLLIAINCVAALSILFFGYDQGMMSGVNNAKDYIDLMGFGYTKEVDGELTPVVTNSLLQGGIVSVYYLGTLFGGLFGGWLGDRMGRIKSIAAGAVWAVIARFINGIGTGILNAIVPVWATETAEHTSRGQFIAIEFTLNIFGVVLAYWLEFGLSFIDGGKSAFRWRFPIAFQIIFLLILFVAVWFFPESPRWLVKVGREQEARYILQRLRGSSPEDRVRAEAEFQDIQSIAEMEKTVVHGNSYLSMLFGWKSGDLHIGRRVQLVIWLQIMQEWVGIAGVTVYAPTIFSIAGFDSMKSQWISGLNNIFYMFATLICVFTLDRIGRRWTLYWGSVVQGIAMFLAGGFSRLAINAKADGNMGSASSYGAAAASMIFIFTSTFGATWLTVPWLYPAEIFPLAVRARGNAWGVVGWSIGNGWLTLLCPVMFDSIGEKTLYVFAASNVITIPMVWALYPESNQRTLEDMDLLFAAKTPWTWDAEKTFARLKAENPGMVDITSRKNSVVDPETGKVISVDALTAAKLDNATAAEHVDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBE8</accession>
    <name>A0A1Q5TBE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trichothecene 3-O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBE8"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="456" mass="49879" checksum="CAEF138FB021B62C" modified="2017-04-12" version="1">MLEHDSIDILGSTPFLYKLYTQLCIIFAVSEPSSAITDTLRDGLDRLAEGFPWLAATVINEGASEGVTGTYRIVPSNDKIPLIIKDLRDDVSAPTMESLRQSNYPFTMLDEKLIAPCLTLNLPGNTIGLAATSAPIFAVQATFITGGLLLTVVGQHNVMDMTGQGHIIDLLSKACHNQPFIAEELSIGNMDRSKTIALLDDPFDPAVELKHQMVRTPPPGKEAGKTNTPPSSTWAYVTFSAASLEALKSQATQTKDTSTPFVSTDDAVCAFIWKCTARARLQRLDPGMESAFARAVDVRQRMGIPSTYPGMFQNMAYNKDILQHLADQPIGAIASQLRRKLDPKVVDLAYNTRALATFQARSVDKTKTSATACVDTSSGIMLSSWAKINTFELDFNLGLGRPEAVRRPAFVPFESLMYVMPKSPNGEIPVGICLRDEDWKSLKADEEWAKYATYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC33</accession>
    <name>A0A1Q5TC33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC33"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="115"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="833"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="865" mass="95338" checksum="5B58949650355137" modified="2017-04-12" version="1">MATAVSKPSSHPPKMKRPPPPFPQTGVNGVKAQQSSSSPTATSQHPLGNISAGSSSSLANGVANLSNNFRGASNRIKTQSQRPSDGASRQTRPVTRNSLAGNDHRTAKMNPEPYGCLIVRVVDHKSLSAQTQKTSVSTSNENNTPFSLHNYNEHVTPSAFVPYPKQNQLTTDVQSIKAPETPAPGQTQTENPASGESAEVQSQVNGSEQKPATPKPRVFTTVLHPTPRALQAELTLLVTTPDPRAALAHHSRTQSSSVIPQSPATTQPDRSHPAKRQKTLVEPQDLPQCESLLVNCLAPPLYLDPVDSFEEAQVLLEFLKSPLHSNPPPSPKRRKRTVAELAADEALAAEEERFMLIMDERLQPTASGAAGSSKTAAVDDTAGVAPFEPRFSRFKTLETIRMQHEEKAKREHEMKLKQELAKRQQQEQEKERRRALEQQQAEQHAKEEARRQQLAAQQAQAQLAAQNRHVMAQPNGVTQGQQSSPIVRHQTPHSTSSPLVGNAIAHQAVPMSISASQQSGSPPRPPSSMQHGHPNMMGHPMAPSRSQQGPSRHGTPQMTQATPAMSQATPIMRNVTPTQRMNQGSPTHTMAQTPMMNQPMAQTPQMNGAGMGLTPQQQMLLQQRQQLLAQQGGQMGGATQFTPQQLAQLQANAHAAQNIKSHQQQQMLQAQQAQQAQHQQQQQPNMQNIPQHSQQAYQAQLMRAQFAQMQMVKQAGGQIQQGQPNQQQQQQLHQGSPQMTAQQQQQQQMLMAAAQANGGQMPNIQGANIAQRYNRIYQQRLLQLRHEMSQRYMTQYGPPTQYPPQIAQQYGAGLEKNAKAWVQDLMRRDREAAQQQRASAMHAQQMQQQQQQQQQQNMMHNGMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD86</accession>
    <name>A0A1Q5TD86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">General negative regulator of transcription subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD86"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD86"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051254">
        <property type="term" value="P:positive regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="453"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="818" mass="88382" checksum="1883067B347D212B" modified="2017-04-12" version="1">MSSSRQQIDSVIDDDDEFCPLCIEEFDLSDKNFKPCPCGYQICQFCYNNIKTHSEEGRCPNCRRPYDDSTIQYKIPDAEEFKADLALKHRKAAAAKKKEAEKREIEASSRKNLAGVRVVQKNLVYVIGLNPTIRDENQLLQTLRGREYFGQYGDIEKIVVSKAKPGGNPHQGIGVYVTFSRKLDAATCIAAVDGSSNGDRVLRAQYGTTKYCSSFLRNEQCNNRNCTFLHETGEDSESYSRSDLSSMNTLSSQRPSHPQQNPPHVRPVQPITHTMRRQPSKDDSLSGRSGAPDGPALPSSASWANKDAAIRTRRASLTGSQASQSPRPASVTVATPAEEPRRIERVERPSPVAQEAPRTSQPVSRSPILQPPVHHVQPPSPEPPAPTPFDNLVKDLMNPNFKFIFSTADLPDEEVKAIQSYPSFIDPYGGVKRRAMREKAEQDRLKREQELLQSAVVEEESREAGSLQLGGEPEESNPPRGPQQSRESHGAIQPPSQQGTADNSTVGSPVSATSHQFQGLNLAGRSLTPLQQQQLMLLKSAGNQQAGIADHLSSAALEQATQLRQGLLHNQMAQFNALQGQSRQSSRFTFANDVGSKNISNARMLSQMQAGTPNPLSAPSPQHVLAGGFYASGVQGPPPGLKTAGTPPISGGGMFAQGHGFTANANIGLGSNMGKQEATPELMRELLRGRGGGTNLGGVQGQEAAKREFMFPFLQQHPTPPPLTPVNGLLSSFYGSQTSSVLDSGGAQKQKKKGKKQRHANTSSGGGGVVDLADPSILQARMHQVGANATAGQALYGSQGQGGYNPSMMYGGGGFSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE75</accession>
    <name>A0A1Q5TE75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE75"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39585" checksum="F4B27EAB8FDB0622" modified="2017-04-12" version="1">MEQYSPPKGGPSSPAASREPRLHLPSTTDPPGPQNPPKPLVWLIFGATGHMGRSLVKNALSRHDLVAAVGRTYENSPESMKELEDEHENCLGLLCDVRARETVKRVIDQTIARFGRIDVIANCSGYGVIGACEDQDEFDIRNQFETNFTGTLNMIQLSLPHFRERRAGRYLIFSSTSGALGVPGLGPYCASKYAVEGLMESMLYEVDSFNIKGTLVEPGHMRRDDIGDLVSPSVMAANPSAHNLSSPLPLYGHFLVKPPSEPYNTPTSPAAHARRMLMWLGDKQPASAVKAAHLVWELGHCSYPPLRLILGTYAVESIRDRLKCIIEEIEDWKHLSFPLGESQPAAGRDKSVSIEGAEGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF95</accession>
    <name>A0A1Q5TF95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF95"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000029">
        <property type="entry name" value="Glutamate carboxypeptidase Tre2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="484"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="730"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="856" mass="95371" checksum="44DBAE5288775206" modified="2017-04-12" version="1">MGDDKFEYKSLPIPTYEEATAHASSSRSDLGDGTDAERQGLLGREASNYQPPTVESERGSLDGLASSASGSTRGSTDELRRELDQMDVDDSGSSSTRPGLRHHFSKRFSSLTRTLSAIQRPLQRYLPRMPSFRFTINLSDTRARMKDHGCIMLLRLFALLLVVSLVYVFFIGDIFNLNNRMVMGQSYSASSVENFVQGHINETNIAENLKLVAGNTRVAGTEGSFVLAEWIEHEFYKAGFDEVKREEFQVYLNYPRDDGRKVAIVDPPHLVWEATLEENGAQYPVFHGHSKSGNVTGPLVYANFGSRDDFKLLADKGVQVNGSIALVRYYGTEGDRALKIKAAELAGAVGCIIYSDPAQDGFVQGPAYPKGRFMPSDGVQRGGVSLMSHIVGDVLSPGFASTPEEKKRLSPEDSPALVKIPSLPIAWRDAQRLLQAIEGHGSKVPDEWVGGVPKVQEWWTGDKSSPTVHLMNLQDEVERRPIYNVHGTIIGLEERDKKIIVGNHRDAWCLGSVDPGSGTAVFLEIVRAFGELLTYGWRPLRTIEFVSWDGEEYNLIGSTEHVEKEIDNLRANGYAYLNVDVGVSGSKFRASGSPVFERSVHQILGRLSDPFANKTLKELWDDRGQRLEPLGAGSDYVAFQDIAGTSSIDFGFEGEAYPYHSCYESYDWMEKFGDPGFVYHKLLAQFWALLLLDVSENPMLPFDMEAYGKSVTGWVKDLDEFAKAKNAEVDMQLMYNAAAELETSTARFQSWNEVWHDSVWGSGGYESNVMAIQRVNHNVRMAQFDTHLLDLEADGGIPNRTQFRHVVFGPELWSGYDASIFPAIRDSINAGNWSLAQHWIDRVANIIHHASNKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF96</accession>
    <name>A0A1Q5TF96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF96"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="40308" checksum="C8F0749F9D34B1DC" modified="2017-04-12" version="1">MAKSSRRKTPSSTPASSGASTPSSVSSGPIPPFTKAPAILKPFLDPLVPEEVYLLHIDTTGTDLKWQTFIVPTVVNVVVAAVIALRVYWGFSTYPALVAILLGMESSLSVDIASTPWTDLAQITLRRVGTILIDYYLLTLFLTWPIYFVIGPVRWRRAIGFRDREIIVRRSHRNWSKKLERNKWIRDNEAMRDKIVAAVTPERIGKTGYLLVDEDWNLDYSAMRRAHALVDLTRKGEGVQLDEFRTAVLVHTDSDGWLIWRVGDENTPAGRQKSAQRDQILAFRERLTAMGKEDLFFRWVELVQWESSQPGGFTPERQRSAMVQAKQMFDEENVDFSQFWDDELGGMDGAQEKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFB4</accession>
    <name>A0A1Q5TFB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rhamnogalacturonase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFB4"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012705272" description="Rhamnogalacturonase A" evidence="11">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO98920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="47384" checksum="52D6A113EE165C1E" modified="2017-04-12" version="1">MHAKNLLLGLGCASVAWAQLADTTDYPMGPLTSSSTKWATKVCDITKYGAVADGATDAGPAILAAFNACASGGVVNIPSGTFAMATWVTLSGGSAWAINLEGTIIRTGTAGGNMIFIEHSTDFELYSSNGKGAMQGYGYEFHSQGKYGPRLLRLYEVTNFAIHDIALVDSPAFHLTLDTCNQGEVYNMIIRGGNEGGLDGIDLWGFDLWVHDVEVTNKDECVTVKSPANHILVENIYCNWSGGCAMGSLGVNTDISKVVYNNIYTVNSNQMFMFKSNGGNGTVTEVTLQNFIGHENAYSLYIDAYWSSISAAEGDGVLYNSITFNNWKGTCANGATRAPLYVLCPSTQPCTNIVIEDFAMWTESGSTEYYKCADAWGSGYCLHSGSAHTSYGTVTSTLTAAPSGYSATTMPGQLTAGFGLSTSIPIPTVPNTFFPGATPATARVYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFC4</accession>
    <name>A0A1Q5TFC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFC4"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="38309" checksum="996C64B3356FAD04" modified="2017-04-12" version="1">MTFGVALIGGGIWAKEEHLPAVLASEHLELKAIYSRSLRSAEDTAQASGKLVELYSEDSNQGYNDVLKREDVDAVIIALPIASQASYIRAALSAGKHVLSEKPVAENVAEAEALIKWYREEIEPQKKATWSVAENFRYLDSFRQAREKVQGLGKIIGFRVKVYGNIQQDGKFFNTDWRKVPTHQGGFLLDGGVHYTAGLRYLLGPDTFITRLSAFTTLLKEYLPPVDTVDAILKTNTGVQGTFQVSNGTSLVGPEWTVGCENGSVSVDFSKITVRTLDGKEDVQDVQDERTGVPPEVRQWGQALAEGKVNPEQSPSQALGDLELLELMLRSGEGDGQPQNCRCQQPANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFD4</accession>
    <name>A0A1Q5TFD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAD50-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFD4"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1420:FF:000001">
        <property type="entry name" value="RINT-1 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="818" mass="91760" checksum="25FD4E69B80C368F" modified="2017-04-12" version="1">MAPPTSLSSHERTRVEDYLNDKIQVSADLESLDSLLSSLRAQQELQRKQLAEAHEALSNATKASNDHAEATRKRAEAFASEQADIDRRLKAITQSETSDEAVHRLEKSMERLQRLEISKGYVQLLKEAEELSKEALTSISSDPRAALNPYARLRSIVLSLKEAQPAAEGAAPHLINYTEKLASALRQQLRKFFGDRLQKTMEALKWPTRELNITDTLLAQWTQDVELLIDLQMPELQGRDVLDTDHGLEPPVLFPLEVMVHPLDLRFKYHFSGDKPTNRLDKPEYFLAHIMDLISQFGGFFTSYLQPILDEKAQSAGPALEWNFYNALHAFITALLPMLRHKIETFMPQISNHPHLLSHFIHELMNFDNDLRETWNYLPDPYAEDDWKGITWELLTKQGWYDRWLQVEKEFALARYRDIIDTPDSGEIDYDGVELTATKPTKAAIRVNDLLETITERYQPLSSFSQKLRFLIDIQITIFDQFHERLREALDAYRTMTSALGRTVQGADGQASVEGVAGLERLCRVFGSAEYLEKKMEDWSNDVFFVELWSELQDRVKQNRDGGRNVAGTMSVAEVALRTSPAVANHDAANPQTSEGALFDETASAYRRLRLQSESIITSTLTSNITAALKPYSRLATWATLSTPSAGVTTSSLSLSSDLAHAMRILSTQLNFLARALGVAPLRRVSRQLLLSIQTYIWDNVLMRNNFSETGAAQLASDIDHLCSVVDNALGVAGHVGGSTRIVKKLNEGLRILNLSAAAGPSAENVEEDSTALGLGDVEKRLFKDNESARAVLAELEIDSLAEAEARSVLEKRVEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFR9</accession>
    <name>A0A1Q5TFR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="432" mass="48828" checksum="77A82B36987F3775" modified="2017-04-12" version="1">MVSSSGPVNYDISLLAPVDYKYNTVGYLVPDGISKVIGGKIRKPQQAHVHQFLWPLFTPPYGTWLYGRFFYEYLVEVVLIALLLVPFLTLLPSGLFKLLARLKGSKRPQNKDWRPWTFNSTYLAFISCITVGLIALVVFLQWRSQQPDPLVQHEIDWSGGSVSSGPWTGDPFNSRIIRSPTFDRPPRGLCRFTITLDGVWSQKNGAQRLGRGVYSAFTYLPMLLAVLYGRMWKVLDDDIKRIDMYYRLQKPNGTTVFCWEVYSGAALDWPDTYSWQVALVEHGWAYKLIGALAVAENCCLVLFILIHSQKTGLSGGVRGIAGLVDLLEEFDAASLKLPSSSSSLSLSKIEEKFASSEFHLIDGKLKWKYGISIDPRVYQIVGILVQLIVDVIDHAVRSLAPFYALAQDYPQDYHRLNILWADYTSNIPPWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFS7</accession>
    <name>A0A1Q5TFS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFS7"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="11">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="29144" checksum="2F56CA77F098E424" modified="2017-04-12" version="1">MEATPEPGHSSTNVDDLFDYDVGLEDIQPNPPPTTNAPKPTTGDPTSLGLGLDEEVKVTKKRQPAPKLDEARLLSQPGIPKLRRTAKRKLRLKGKGYEFQDAERLLNFYQLWLDDLYPRANFADGLSIIEKLGHTKRMQVMRREWIEEEKPKPFGDTIIMPDFPTRPSDQNGADKTETSAPAPSGSNQVGSDGDDLFMPDPEAENRPPVSHPEPDDDDLEDLLREQEEVMSGMPEPASRPQNTEFDDFDAEYEAMNDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFY0</accession>
    <name>A0A1Q5TFY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_8471</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFY0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000017">
        <property type="entry name" value="Inositol kinase kinase (UvsB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="136"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="12">
        <location>
            <begin position="441"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO99085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="54255" checksum="FE19B0797D0F351C" modified="2017-04-12" version="1">MVTKAVQSFPQQGLWTVLAVVKSSNKDRALKGQACLSKIQDYSSKVKKDTTEIRRMILQGQKFSDELLSLCLARVEDRASKVTLARNLGFNHKVAPCRLVVPFQAMLIPSLPVIQDSEHLKGFRPFPRDPTTIEAVLDEAQILNSLQKPRKISIRGSDGKIYNALCKPKDDLRKDQRLMEFNNMINRFLKRDVESSKRRMYIKTYAVTPLNEECGIIEWVDNLRTLRDIIVKHLRERRIAPNYTEIRHYLDEICADKTFSKLSLFNTKILTKLPAVLHEWFIEMFPETESWFTARLRYTRSSAVMSMVGYVLGLGDRHGENLLFEEGTGGILHVDFNCLFDKGQTFEKPEVVPFRLTHNMIDAFGAYGYNGPFRRTCEITLGLLRQNEDALMTILETFLHDPTTDFIGKRRRTHVNVPDTPAGVLEDVRNKLRGFMSKQPIPLSVDGQVDELIVQATDKKNLASMYVGWCAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG09</accession>
    <name>A0A1Q5TG09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG09"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO99150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="545" mass="59311" checksum="DD93B7CFB5E9CE14" modified="2017-04-12" version="1">MATDKRADSLATKPKQTGKAETEHDETIYAEPSFLQSVSYGPGGISGIVSSPYVSGAAVLASLGGFSMGYDMGVISIINVMDQFHTKYPFAATAFGKEFMTAMLLLGAFVGCIFMPYAADRYSRKWALTAVVVIFDIGAIIQTAAPNYGALVAGRFIGGIGVGTLAMGAPLYISEISPPNIRGTLLVLESISITSGVVIAYWISFGSRSITGEGAFRLPFGLQMITATLLGAGIHFFPYSPRWLALVNRSDDCLKSLERLRRLPTHDERVQAEFHGIMAEVNFQKLAQQKRHPGISGIKLELALWADLFKRKYWRRTAVGVGVAFFQQFSGINAFIYYAPTLFTSLGQTNEMSLIMSGVFNILQMVAAVVCFLIIEKVGRRPLAIFGGFGTAVTYAIIAILSGLYEKDWESHRSAGWACVAMAFLFILTYGVSYSPLGWALPSEVFSTATRSKGVALSTCVIWLCDFIIGISVPSMMENITYGTYIFFAAMCFLAGIWAYFLVPETSGKTLEELDEVFGDTSGQEERDLVAEAMQATRRAAETTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI50</accession>
    <name>A0A1Q5TI50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8115</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI50"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="10">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="9">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="8">
        <location>
            <begin position="260"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO99898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="446" mass="49289" checksum="E62504B1C73B6B38" modified="2017-04-12" version="1">MSASTRIPPIAQPFVSDRAKKTLDLVEEFVEKDCIPADAVFSAQLGEGEKRWQTTPAIMEELKLKAKKLGLWNMFLPKNHFKQGAGYSNVEYGLMAELLGKSKVASEATNNAAPDTGNMEVLAKYGNEAQKQQWLVPLLEGQIRSAFLMTEPDVASSDATNIELEIRREGNEYVLNGSKWWSSGAGDPRCKIYLVMGKSDPNNRDTYRQQSVVLVPADTPGVTIHRMLHVYGYDDAPHGHGHITFKNVRIPISNMVLGEGRGFEIIQGRLGPGRIHHAMRTIGAAEKALEWMIARVNDDRKKTFGKPLSSHGVILEWIAKSRIEVDAARLIVLNAAIKIDQGDAKSALKEIAQAKVLVPQTALTIIDRAVQAYGAAGVCQDTPLAYLWAGIRTLRIADGPDEVHLQQLGRRENNSRKDAVTAKLKWQQEESDRLLIASGFKAKSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI81</accession>
    <name>A0A1Q5TI81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI81"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="431" mass="47500" checksum="60B4FBCCADE4596C" modified="2017-04-12" version="1">MSEGHAAPVADAPVATAGDSTGTAPVTVGKAHHVDNNNSHAQAHSLKEQESTERLTPRPTFMENLANSRDAQFHLDRRDSSELERYFVSGYCIKKWADGRKYWAQLIQTSRNLSRTIWVNTSEREGEDGKVDLLRKVTAMNLILAYAVALKHKLRFEPDVAYEDLAGLIGHLDTFARDAHDREVLNPRPKSLWKATGEYLGVSFAESNPRKLIKRSKKPLGHLPLEILNHLSAYIDSIVANGTLTSGLHQSQAITMLSTLNEVLTGTERVLDTPLPAAYSIAISQIAWIYVMVLPFQLVKVLDWVTIPGTMVAAYIIIGLATIGSEIENPFGHDVNDLPLDTYCRQIAVEMDIITATPAPKVDDFMSRPDNLVLFPLSQNSYDEWKARSTEDIRAALRAKVTAGTALTSALDGSDGSTLVTRITTKTKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TII5</accession>
    <name>A0A1Q5TII5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TII5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TII5"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="549" mass="60804" checksum="B560FFF33E5FD5A5" modified="2017-04-12" version="1">MSDEIKHQPTQYTAAPGTELLIDQEHFSSVHDYQHVAHGDGRIILVPQPSLKDPNDPLLWSCLKKWLTFGNGLFYAFNGAVTGPMMAGGMVQLATFFRRPLSDITYSNGATLICQGFGTLLWMPLAVKFGRRPVYLASNALMGIACVWLAIAAEKTYPQFVVARAFLGLFEAPIEAIVPSTVTDIFYLHERGEKIALYGLSVLGGNELGPLASAYIIQSLSMRWAFFITAMSIGVSLIMMFFFMPETMFTGPRPKIVSVIAEETNKINESEGKPSCEHVDGDTSMNTVPRELESLTTKKRSYRNELFQVGINHDISFWQIFKRPFILMAYPTVVWSSIVYGMSLSWNVILGSLVAQLFAPPPYFFASGAQGLVFISPLLGSLVGTYLAGPLADQIATWFTARNLGFREPEMRLPTCIVAAFLTFVGALISGLTYHYQTHWVGPIVGFGVLSAGAQMGATLAISYSLDCHKELSAEIMVTISCLKSGVAWIWTWCINDWVSSSGLLTVLMSVAAINVAVYMTTFIFHLYGKKIRIWLHKKNFMGEESERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJH4</accession>
    <name>A0A1Q5TJH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetracycline resistance protein from transposon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJH4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJH4"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="432" mass="47596" checksum="078DFAC3F1453352" modified="2017-04-12" version="1">MSNSKPAPIAIVGGGPCGLTLARLLECAGIDYIVFERDASAVPAPAFQGGTLDIHGRTGQEALRRAGLHGEFEKLARRDATSMVVQSYKGEHFMKFGEERDAPEIDRLQLRQILLNSIPSHRIRWGKALCAIERDTNQKPTDARDIVLHFADGSTETRFRLVVGADGAWSKVRQLITPAKPHYAGKMFIEGQLSLDNPRYQAAHEMVGLGNSIAMSADAILCVQQMHDRSYRVYMGIKGPQDLTRPGGELDVTNTDKTRAALLAPAGFYGNWAEHLREFVAHAEGPWRVWPWSKLNPDLLVPEAEKAAHDDVQNKDVWKRSPGVALMGDAAHPASPNGGGVNEAMYDALRLFESISVEIGDKNDVEFDATMDAEALERAITAYEAEMLPRGREHIQDGMNVEQMFFGEDAAKTLIETFAHAKPEANEPQMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJX5</accession>
    <name>A0A1Q5TJX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBA domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJX5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="735" mass="79828" checksum="FFFCC2C8DF5D7686" modified="2017-04-12" version="1">MPSGISKRQQLRNEKALADLIRTVPGNDRCADCDALTPGWASWNMGIFLCMRCATIHRKLGTHISKVKSLSMDSWSSEQVDNMKSHGNLLMNKIFNPKNIKPPVPTDIDEADSCMERFIRQKYQYRSLEDGKPKPPSREDESYTRSHERREDRREERRERERQRSYDDSHRDDYSPEGSPPPLPPKSGKFFGFGLRSASSTSNLRRFGTKSKGSNSPTYDQRSWSPPPRQTTGLGAPVADVTTDSFEAKMAALRDMGFNNDRRNEMVLRGLNENLDKSIETLVRLGEGNKPVSRAKTPVPATNTATKAGASVAPKSAPSPNPFDMPTATQQLQNPSYNPFDRPAQTQTPQSAQNLEASFQNLQVSQPLFPHSTGGYPAQTGLMPQATYQQPITPPATSTFQNGYVSSPQPMDNNYNPFFQPTAQPQGGMGAQSFPHPSAPQNNPFFNATPQTQNPYLQPQAQQNTASVQSMTVPRQPQHANTMPAISSTSPFGTSPFGTSPFGQVPSFQTQPQQLQLQQPQQFQPQAQPQATAQGSYNPFQQSMGQQSAGGYPNQLQPQQPQQLMPQHTARMDKTSILSLYSLNQAPSTIPSIPEQSQYQFQPGAGTSPAPPLTNSLNSTPMTQPGSNIQTPQPSANGPAMASRNPFGAATVGSGLAAQAGVTAFPPSSGLGIGMGTNGAMPANGMKTSPFSGPPPVTVAFQPRTHISQPSVDINGLQSGRHSPDAFASLSARYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKK9</accession>
    <name>A0A1Q5TKK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carnosine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKK9"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044400" evidence="2">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="422" mass="46407" checksum="C9AB9D3481C4075C" modified="2017-04-12" version="1">MHISTYLSRSLYILLCVAVPLYLGIRGSDSSFGTDFLFSSLSERAKALHVALTSPLAAHSAPNHEAPFQASVEPENPVRAPGEGRGKRYPSVLAGLAHCINSFEQYPFLAEQVLQRKYARYSKQTPAQMAISKKLGYPAHFEKARGGIEANAQFSEKIAQIAREKYDIGPLSLNDNEDAEFGVIDSAFSLLSRDWSTQGAKERQAVFPPILSALGQHFGGTGGGSKVLVPGSGMGRLASDLADIGYNVTANELDYGSILAYHLLTSHTSSLHQHTFQPFVTKWTHQADPSSRYSAITVPDHWPNKTVKLVEGDFLEMFPSDGEFDAVVTLFFIDISKSVIDFLSNIHRLLKPGGIWINLGPLKWGTHTALQLSAEEVLQLADLLGFDVDHTSRKSIDSLYVEQPETLLKFTYGECLLFPCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL98</accession>
    <name>A0A1Q5TL98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_7585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL98"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP01004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="16531" checksum="1724FC8D376A5174" modified="2017-04-12" version="1">MSDEQTFIAIKPDGVQRGLVGPIISRFENRGFKLVAMKLTSPSQEHLEKHYADLAGKGFFKGLISYMLSGPICAMVWEGKDAVKTGRTILGATNPLASAPGTIRGDYAIDVGRNVCHGSDSVENAKKEIALWFSPSEVLNWKATQAQWVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM53</accession>
    <name>A0A1Q5TM53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_7308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM53"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP01318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="526" mass="56960" checksum="D78F1CF1A5DC4644" modified="2017-04-12" version="1">MGFLIQKPEGTPGSAWPAIAIGLFVAFGGVLFGYDTGTISGILAMPYWQDTFSTGYRDSTGHLNVSSSQSASIVSILSAGTFFGALGAAPIADRIGRRWSLIASTHVFILGVILQTAATAIPMFLAGRFFAGLGVGLVSALIPLYQSETAPSWIRGSIVGSYQLSITIGLLLASIVNNSTQNRKDTGSYRIPIAIQFAWAIILITGMLVLPDTPRYLIRKGDRAAAAQALGRLRRLPADDLAVQDELAEIQANHEYELTLGKSTYLECFKGNLLKRLATGCGLQALQQLTGINFIFYYGTQFFKNSGFHNSFVISLITNCVNVGSTFPGLWAVEKWGRRPVLLWGAIGMCVSQFIVAILGTTTTGQDTAGNIVVHNEPAQKAAIAFICFYIFFFAASWGPCAWVVTGEIFPLKVRAKSLSMTTATNWLLNWAIAYSTPYLVDYGPGNANLQSKIFFVWGACCFLCISFVYFFIYETKGLSLEQVDELYAEVSSARHSTSWTPTITFLAIQEGKATAAHEEKAAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP23</accession>
    <name>A0A1Q5TP23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_7210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000069">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP01980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="165" mass="17581" checksum="0634A289C3F479D8" modified="2017-04-12" version="1">MPPINAPITAQELSTLSTKAIDAKAAAYCPYSKFRVGACILTASGEFVVGANVENVAYPVGTCAERVAFATAIVAGHKEFRAIAVATDITPGASPCGMCRQYIREFTTPSFPVYMYDGEGKYTVKTMGELLPDSFGPDDLPRRQKLAKRLETVVSGASKLCKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRL9</accession>
    <name>A0A1Q5TRL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRL9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRL9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP02851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="45827" checksum="4589FB24CD21ECA5" modified="2017-04-12" version="1">MECEVEDSRSPFGGLYAYPAAADSGLSPVLLTRARLLATEHVKLSEKLAEAFDAKVAKRVGEIAPVTTVLKEWDSANESIIELKSLLEQPETDDELRSLAIEDLDSTREALPTISDRLKKALIPRHPFADLPCLVEIRPGAGGDEAGLFAFEMLRMYMSFCSRRGLRPTILKQDVEDGASEDRLSEGVIEIEADGAYDIMRTESGVHRVQRVPATETKGRTHTSAVSVMVLPSFPESGSGADNALNFEDPNSDYYIDPQEVRVEKMRASGAGGQHVNKTESAIRLTHIPTGTVVSMQDERSQHSNRRKAWQVLRAKIAEARQEAREQELVQLRRGAMGGVARMGRGDKIRTYNYGQSRCTDHRSGTTIHNLDGVLDGGDGLETVMESVRTWMADRDVETMVAEELLKEEKTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXM3</accession>
    <name>A0A1Q5TXM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="21016" checksum="6AFB7A1135E15A8A" modified="2017-04-12" version="1">MVENQITIPALAKLARDVLSIPATSAGVERLFNTTRDICHYRRGSLNATTIQERILYRRATQFEVKEDDIAFWIEYLSKGETEADQEEKDAQQVEGTVDRISEDEESNTEDTQEDLVLVQAQSATQGPSKGAPRKRRKSVASEPDTEGHRDSNEEEGIPLPDTQQRVSGRSRKRPRHNDDQFIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U041</accession>
    <name>A0A1Q5U041_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U041"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U041"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="76"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP05836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="45704" checksum="C35633BADC34CFD4" modified="2017-04-12" version="1">MTVQPAEFLAGKRIAVAGGGFAGLSFVLALDQLWQGSTLDRPEVLLYEQYSRHESLQKDPYTLCVNGASQDDGLVAIQQLGLLDAVREHSTLNDGDIRVWSDNWKWLSSINPTAYGNLPAATVRITRQNLMRILVEKAEQTKTVLRWGSACTSAERLSNGQIRVSISEDIGSANSSTLDCDLLVAADGANSRIRASFRPNDMTTQYAGATQIGGISYLPGGLPKPIDQDFVLQMSSGEGVCCLYHPFDNNTIAWELSTVGPEREAKTNFNTEELNALKQEALKTASMFQDPFKTVVEATIPNTAFIRPAKEKPAFQHDARLHGVMFIGDANHILSAFEPLGANLALKDGWDLAEQLCRNISLDAAAASYDRLSIPRFQHNFNFSHERIGFGHCTGSKWMFYKYGMAAQRALKKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U070</accession>
    <name>A0A1Q5U070_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U070"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29066" checksum="A8CD68D13B3B014E" modified="2017-04-12" version="1">MSSWVITGVSRGLGFEFVRQLSEDPANAVFGLVRDKAAVESKVAAEIGRKNIHIIQADTTDPMALEKAVQYVSEKTNGALDYVIANAALQSKTALVGFDTLSRDPEALEQDVIDHFRVNTIGAVHLFNAFMPLILKGRAKKVIAISTGMSDPEMTLKADIYQAASYAMSKAALNMAMAKFSALYREKDVLCMAICPGAVDTGSLNIETEEEGRLAMAMFGKFKQYSPTFHGPMKPEASAKSVLALVDRATVDGGYAGVFLSHTESKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U094</accession>
    <name>A0A1Q5U094_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U094"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U094"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP05871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="250" mass="26853" checksum="E55F5AF894D37B7D" modified="2017-04-12" version="1">MALNGKVALITGGVKNLGAESARELAGVGADLALHFNSASSKKNAAELEAELKQKHPNLKVAFYQGDLTSAAAVDKLFDSVLKDFGKIDVVVNTVGKVLKKPITDISEEEYDSMFAINSKAAFFILKAAARHISDDGKIITIVTALLGAFTGFYTSYAGSKAPVEHFTRGVCKELQARRVSVNNVAPGPMDTPFFYPQESPEAVEFHKSNGMGNRLTMVQDIAPVIRFLCTDGAWITGQTIFANGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0E9</accession>
    <name>A0A1Q5U0E9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TOXD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0E9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0E9"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="40512" checksum="9C7D9C972AC6858F" modified="2017-04-12" version="1">MAQIKIQSGIIMTGIGKAQIEHNLAIPAPDPGQVLIRVRAIALNTPDWMALDYFGRPGAGMGFDFAGEVVEVGAKCEIWKIGDRVAGFVHACHAANYANGSFREYLLADADLLMRLPDHLSFAEASTLGMGVSTAAQALYQWLSLPLPACDAKPSNETVLIYGGSTATGSIAIQLAKLSGLKVITTCSQQHTSWLRSLGADEVIDYRNPSATETIRSLVQKDGLYSILDCIASTQTAAFCYKCFSVPRHASELPPSLIYAGLMIPPEEPPRPNSLPPSADIHSLWNIVYTCFGRRFTMVKEEIGLKRTWEASASDKEFMVAFYRRVEEFLQNKMLQPMPIEIRKGGLVGALEGVSEVRKGAVRGKKLVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0G6</accession>
    <name>A0A1Q5U0G6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0G6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0G6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="715" mass="79604" checksum="EAC8367DA1226352" modified="2017-04-12" version="1">MAEVVAVIACVAAVGSKSVVSAYQDGHKLFGAIKKKWREHRRPETINTEPTTNDLDWSLRRGEEEIMTQWNSYAGQMGRRFEDGDRVAREQMKDIVIELQRALLANLRENNAQLNMFALLQASDRGRTDTIWVFHNLQQRLAQAASIPSPLDFGPVPFDPASRLWYWINLIENHYQAQFSPSRYIQSLPSSPGGRLISGGMSGSPPDIIGFLRQMEEQASPSQSRRSSGIISPSSPYPGRRQSSGDMYSPWPESGSRYGSFVPGAGLAPMPEMPDQHYTIIDRPREGSSGSAGIYGADMDYLQRDRIPTGRPQQTFHRDQAREEMQDYLHEDQPSSARHEIPPSQSVRNNKDVDHLTLEMTENPWIMDATEPTDTHRQRTYSPEPIPEPAMPEVVYRTNIVDTRHLVGMESPWAAQPTPPPIPEQRRSTMMDSGFESGRCIPQVRAEETIRQEHYTNPFPRHHHRPPTQDRPLPHLPLPQRQNSHDAPIPVLTSTPSPPHLTPLQPRTQHTPSISSTTSTISSTSSSNPSSTRPYWPPSTENNYAGFCKGAWKVQSGLGGFKVHSEPKGYYGMESKWRCGTCFFEMPLSPDSTRNNPNYDSRLLTHGGTGIRYRWLFLAKSHMNCKRSVKPGGGLFGCIFCCRDRGGPVQGFGGLEKLMLHLGAEHRDASGVGVEGSSLLEGARCVVGRVAGVEEGFDVNIPPEGLRGGGGRGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1X7</accession>
    <name>A0A1Q5U1X7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyisobutyrate dehydrogenase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1X7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1X7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="198"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="35443" checksum="FA8A8E41045ADC25" modified="2017-04-12" version="1">MDQMHLSPKRGQLEERRGAEVEELGLELMSYGLGSMGLAMANNLQRHLAAKKALSLLYSNRTMSRGGPLQALGGIPEPSFDKLVSRCGIIFTMVSNDSVLQTLISSALSSGNSLKDKIFVDCSTVHPQTVSSAVAQLKAKQASYVAAPVFGGNPIAVDGKLVFAIGGPGSATEVVKPLIQDVMGRKVIECGEDATKASLLKIAGNIVTVNMMEAVGEAQVFAEKTGLGTGPMEELIGEAFGPVAGGYSKRLTTGVYAPPLDARPGFGVSLAIKDARHAMSMAEVHGVKLPALELARKNMEAARNYAGECLDSSSMYGTLRQQAGLPFWNEKSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3V4</accession>
    <name>A0A1Q5U3V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3V4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3V4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="300" mass="34924" checksum="AEF79B769A5D56EA" modified="2017-04-12" version="1">MHYNFGSLAQREGFKDQLRVHGIRAGVANCIDPKASEATRGQALDHQNHDTHIKYQSVLKSLDIQALFYDLEPDYECRNMEQSMAHHRDPNAPQRLDAAAITAFEERDDIKAMKWRIAFLTAQIAGKPQLNEQLAVERTQLYNRKAKCLEAWKKAFIQDWWHSAYDEYVSGNEFTERDGTSLFNIYQKYLPEHARLRESLFTETSLDSVISQQCLEDIVALFTSTERVVYYPGLLPEENRCPICSKLMSHLLLSTSLLRKDYTNVTNLRRHFFDAHSIEETRSNCVSRKRKWQTEDQAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4J0</accession>
    <name>A0A1Q5U4J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myosin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Class I unconventional myosin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Type I myosin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PENSUB_5982</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4J0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4J0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001411">
        <property type="term" value="C:hyphal tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000254">
        <property type="entry name" value="Myosin I MyoA/Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054489">
        <property type="entry name" value="Myo1_CA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22773">
        <property type="entry name" value="Myo1_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="22">
        <location>
            <begin position="49"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="23">
        <location>
            <begin position="786"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="1080"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="19">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="965"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1048"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1139"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1143"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1205"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1227"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="142"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OKP07393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1254" mass="137756" checksum="B2AD9209ACEC1809" modified="2017-04-12" version="1">MGQSRRPAGGEKKSRFGRNKAVADVGDGRQTGKSQVKKATFESSKKKEIGVSDLTLLSKISNEAINDNLKLRFEHDEIYTYIGHVLVSVNPFRDLGIYTDKVLDSYRGKNRLEVPPHVFGVAESAYYNMKSYKDNQCVIISGESGAGKTEAAKRIMQYIASVSGGSDSSIQQTKDMVLATNPLLESFGNAKTLRNNNSSRFGKYLELEFNANGEPVGANITNYLLEKSRVVGQITNERNFHIFYQFTKGAPQKYRDSFGIQQPQTYLYTSRSKCYDVPGIDDVAEFKDTLDAMKMIGMSEAEQDNVFRMLAAILWIGNIQFTEDDSSNASITDQSVVDFVAYLLEVDSSQVNKALTLRLLETARGGRRGSVYEVPLNTVQAVAVRDALAKAIYFNLFDWIVERVNQSLTARGSITNSIGILDIYGFEIFEKNSFEQLCINYVNEKLQQIFIQLTLKAEQDEYAREQIKWTPIKYFDNKVVCSLIEDKKPPGVFAALNDACATAHADSGAADNTFVGRLNFLAQNPNFEGRQGQFIIKHYAGDVSYAVEGMTDKNKDQLLKDLLNLAGSSSNQFVHTLFPNQVNQDDKRRPPTAGDKIKASANDLVTTLMKAQPSYIRTIKPNDNKAPREYNEGNVLHQIKYLGLQENVRIRRAGFAYRQTFDKFVERFYLLSPKTSYAGDYTWTGDSESGAKQILRDTSIPAEEYQMGITKVFVKTPETLFALEAMRDRYWHNMAIRIQRAWRNYLRYRIECAIRIQRFWRRMTGGLELIKVRDQGHQILQGRKERRRMSLLGSRRFLGDYLGVGNKGGPGEMIRSGANINSSEDVLFSCRGELLVSKFGRSSKPVPRILVLTNRHVYIVAQSIVNNQLVISSERTVPLGAIKTVSTSNLKDDWFSLVIGAQEPDPLLNCVFKTEFFTHLSNALRGSLNLKVGESIEYNKKPGKLAYVKSIKDPAAGAVDSYKSSTIHTSAGEPPSSVSKPTPRAKQVAARPVTKGKLLRPGGPGGGPSKLSAAARKPAPVAQPLPQSTPQPAAQPRIVPQPVAAVTAAVAAHSRNQSTSSVRAPPPPPPAAPPAAAAAPKKPTAKVLYDFSSDRANELTIRAGEIVQIVSKEGNGWWLCMNTTTSTQGWTPEAYLEEQVAPTPKPAPPPPPPAAPRATPSPIPNGAGAVAAAKSKPAPPAPPAKRPNMAGRKPAPPPAPRDSTHSMNSGDSSGASGRGTPNSTSNASLAGGLAEALRARQSAMQGKHDDDDEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4K1</accession>
    <name>A0A1Q5U4K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4K1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4K1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP07403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="583" mass="64455" checksum="3BDDFA35AD89D64D" modified="2017-04-12" version="1">MPRKPTPAGKQRVRTGCLTCRKRRRKCDEQKPRCANCEVKGFTCKYGADLAFVPPRSGEAGGGARQVYGTITFVDDSPAVHTAAKEKSQQPSEGASELQASDFEKSEISNPVDATVYHNPPETRTTLDLNDILTSNTPVELHQRPSSFQHASTSLRQTHGAFNQGVNHSLLAQISSRSTTLLSSNHETDLLRHFRYHIGPWIDVGDPDCALGIQVLLLSRTNRPLQAAILALSASQRPLIAVPSHMEDLDSSLRFRGEAEDSLDLETESIGHAGRALLLLQDLLQSGLQDWRNLLSPHTEPLGFLVHPAALEEELGEGIFWLHFRLDLASSILAAKQPLIPFRSYINRDGSPIQTPLPPLQPRSINQVYKHALSLLGHCLSLIYGGPDASLPQPGSPSQFAAFPALQQSHFLSQWTFLWSDCQKWYNERPVDAQQIVDIRGGEADQIDPDHDSALPILIYTTPMALVANAVYHITSLLLLGHKPRLLKSLPGPRCFTSHIWHAQSIAGIAASNESPEQWDPVLVASLLLIARDMTHQSQQAVLMGIFRKITATTGIKLDRETEALQSVWKIARFDEDSDEMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4V6</accession>
    <name>A0A1Q5U4V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4V6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="815" mass="86359" checksum="E5052030548C4774" modified="2017-04-12" version="1">MQAQSRIRQIVSIDVGAALGSREGLKYVKPSSSLIKEAEVRDDGASTPVATVAPIQVSRAWIPARIRVDYFRKDPHSILDRVAAATSTNISLDHSGSKGITIRVSADVPEKVDDAMEKLGKLDPLLVRLMNEQSPESTTDILLLQALINTPHRAFASYVPDTFGLRFGILELEKLNDIAPRRILVDPKSQIKYSIPGFLVPVSCRIDPGTSTFRISEHLRNPTGIETAVLGGNRQTIRCWSGFTYPAVGKPGENRGAQYSGLVVVNQPALPGAERSAAVKSQARASASVKQGQEADTKVTPARPSKSPLETTGSERTARVGRPPLASRSVSSSLPSTKLSGVKTRRPVLPDGTVPLTKARAPTRSTTPADSKKSTQSESQGSDAQKKVQSEVFGPGKRRPSLVFAKEVLEEILNSTEEVEKPQSSPERRLSTGSSSVSSSKFKVATQSAISSAQPVTQTSTRTGAHQEQQKCINLLDNEPVIAGDEKTTPASSHFEVASLSETASTSPVLHSAKSTKDSAPSESPAFQAASSEVSNALSEYTQNSSKSSRQVPESTQSPVLAGDAVFHDDQETPRPMKSLPLTPKGPASLPADDQSTPQLTRSLPVPPAEISIIPDDSIRGTCGSAESPSSVVTGNPITAQATGYGGPTTQMNWSPSYTVSPHSVSSEAWFQGLGIVFGVPTQGPLPLGHDMYVPFMPSLCPGHPIILQPIYCPTQFPGFSMHPSALATSGPSQWSTGQAPPISQQQQQQLPGTTFQQRQTPSQHPSASSLEYGGGSESSAASAAGTAATSGDSSQPRSQSIVPQSQRDSVDRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U598</accession>
    <name>A0A1Q5U598_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U598"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="470" mass="53494" checksum="0E8B5ADC56BD6AA9" modified="2017-04-12" version="1" fragment="single">FFAEEIMTCLMRSPRLESDGFGFREDDDSPFVYDIGRNKSHETWWYKFPRRYKCQYLHHKVKRDLHSRCAFSAFVHKLLELPHEPRTPKEEHELVDKLIDAWICGKFYRIRDLVDPNRCEKYFQDHQMSSLTRPRYGPWEPFEITMSAALATSAIRRGDYVELKALLSHHKDLDTYRYTPGGVLGRASGRFGGICPLDLAAKRASADIAKVLTTNQCHSEYITSKYGYTDRMLTVATKAGNREALKVWIDHLKSTGGSLYENLHSAVRGAILIQRWDMVDFLEMECGVIFTETKIEAQVESLALAILSRRVDTVREILDQGGFDINTKTEQRPYGVMFTALLEKPTSLPIMNLLLDHGANPNESHLKTKLLPLHIAVKKGDVGLARVLVEHGADIRAASLVPVKKGKLHLLLSAAQQRSTPLIQFLLMQGMENSFTSQGKRWEVKESALPRGANERVGYEFGSYVAVIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5V5</accession>
    <name>A0A1Q5U5V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cocaine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5V5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5V5"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="452"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP07863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="711" mass="79172" checksum="BF08E7E27DA3A3C1" modified="2017-04-12" version="1">MSAQGIFSDVVGLSYHCNSTIGVTATDCTYSYDDGAVVTFSIGDLVIGQSVGKNFLTIYDLVPIETSYSDPKLINRARLLFSFTTGQGLEAPIIIDSKIREAIKKYASQIDLDSRNLSDIDVPLAGICNELGLFPKTVSHTRNHLRRYEAGFKVMRDLKIPTQDGSYVLGDVYLPLQPEKRYPVLVSCTIYGRRVFYSGPNLESQDEIAAFERAEDEWHSTASTVEIQVPREPWGKSWALQRGFENIGTFNTFTYVPRGYAMVKVDPRGVSQTPGTRGIPGQITSDFRDAVEWAAEQSWSDGNVAMVGSSYGANTQWDVARLKPKGLKCFVPYATDLDLYREAAYTGGIPAITYLADWFSRVQACSPQWGESTDLMQLMNEHPFYDAIWEMTNKSLDQCDIPCFLAAAQIFMIHGRGAYEAWRACNAENTHLQLVARDYYPWPSRESAGKIMQFLDHHLKGNEHPKPETVGIHVRLGHGRWYWRKEKTWPVPGIQYKKWHLTAEGMLATDPGQDPATEFAYSTKAPVTGKSGVSFYSSPFEEDVEFAGHFSATLSISSSAPEADVVVTLWPVHGDGQVVPLGARGQPEPLAKGFLRASHRKTDGAKTLPERPWHTHTKADNAPLHPGEAVQIDVEIYPAAAKIRKGWKLRVDITPSEDQPDIPGYIKPDFRVMYGEVHEKGTNTILVGGGRTNYVLCPVVPPKEDYPNVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7V7</accession>
    <name>A0A1Q5U7V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7V7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7V7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012931311" evidence="3">
        <location>
            <begin position="23"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP08567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="41723" checksum="38CFEC83A7CD72D9" modified="2017-04-12" version="1">MLRLRGLTLWCVASLILGLSTAQNGTRPVSNELFNSLEELSRLVDISYCVGTTGVQKPFQCLSHCVEFPNLELIESYIPYTGDDDKDNNDSTTPLPAVHCENCTVHAGFMKSWLNTRPIILPIVLQALQDHPDYEITLVGHSLGGAVATLAGLEMRLKGWDPLVTTFGSPMVGNAEFATFLDEAFQIGKFSRDGEDAEASRIRRVTHVDDPVPLLPLREWGYSPHASEVFISKAELPPAQEDVLICSGDEDVRCIAGAETSAISLLDVLQDLDIPLDIFNTKVDPCLEEEEDLQQDPQPDQHQQVILGKQRLVGSSRCASRAEDETAPLYPRHWDWSLIPARYRLWELFYAHRDYFWRIGLCVPGGDLFKWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAC9</accession>
    <name>A0A1Q5UAC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arginine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAC9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="39"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="59590" checksum="8ABE1A78B687B5D8" modified="2017-04-12" version="1">MQVQPQDAVNQYDVDYEKHGAGRESNPLPDLKRKLKSRHLQMIAIGGTIGTGLFIGSGTAIANAGPVGALIAYIFVGTIVYSVMTALGEIATYIPIPGAFTSYAARLIDPSLGFSMGWIYWFSWASTFALELTATGLIIQFWDETISIAIFIAVFWVMIIAFNMMPVGFYGEMEFWFSSVKIITVIGFMIFAICMNAGVGKEGYIGFRYWVHPGPFVPYLIEGDDSLAKFVGFWSCLIQAGFSYQGTELVGIAAGETENPRKTVPSAIRKTFFRIVFFFIFTIFFIGIVVPSDDEDLVNNSGASASNANASPFVIAARRAGVNALPDIINAVLLTVVLSAANSNVYSGSRIIVGLAQEGFAPRFFKRTTKGGVPYYAVGFTALFGLLGFLNVSNSGATVFTWLLQISGVAGFITWASLNGCHLAFMRALKARNISRDVLPYKAIWQPWFSWYGLFFNCLIILTQGFTAFIGGFQVKSFFINYLSLILFVVLYLGHKVIFRPAFVKPIEADLDTGRTSPESENWETVEPTTWYGKAWHWISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAE6</accession>
    <name>A0A1Q5UAE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000520">
        <property type="protein sequence ID" value="OKP09444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8511" checksum="FAB1BA2BB19594A5" modified="2017-04-12" version="1">MRGTLMTRKAFATKLAQHDSLGRENIDVINALDTGQFSSTQDGRPILTSRYSNKDPAIHRMKRHHNFNRLEDTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAV0</accession>
    <name>A0A1Q5UAV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAV0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAV0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="78"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="408" mass="45653" checksum="4AB3FD359A2EFF81" modified="2017-04-12" version="1">MGVQRFLAATMCGAALIAPTLATIYWAGIDESGGEFAPGVLPGAFGVDYAFVNNSAVDIYVEESKVFLTFYNSISEDRIKELTRDFHLSKINLFRVAFLLERMCPLEYGLGSKFNETYFMHYKEAIDHITLTRGAYAILDPHNYMRYNDASEQPLSGSIIGNWSDPKAATTQQFGEFWGELASRFRHNEKVIFGLMNEPWGTNTSLVLKNDQSAIDHIRAAGCEQLILAPGNDWTGGHSWHDNGEDSNANWMWKLRDPIHNTAFDIHEYLDVDFSGSHVDCVSDPRIFLSNLTSWLEDHHFKAMITEFGGSNTTGCYDMLKVLIDYMEENSVYIGWSMWAAGPLWGSQSACCENYGFLGSLEPDSLAIDGSPGLYEQVWLAHMKPMVPKKLVWSGVSSVRGGKKTLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAZ0</accession>
    <name>A0A1Q5UAZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAZ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAZ0"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="36870" checksum="F3E475343F81F88A" modified="2017-04-12" version="1">MSTPSGKHLAAIVPQHGGPLTVVERTTPTCGPNQLLIEVHAIAFNPVDIYQRDIGIFIEEYPAVVGSDIAGIIVQTGSDMSPNIPKPGTRVTALASSFYHNGNPNYGAMQKYVLVGEDTVAILPDSFSFVEGCVFPLAALTVWNGLLWAGIAREPISPAERKGVLVWGASSSMGALAVQGARNMGYTVYATASSQHHEYIKTLGAARVFDYKAEDVASKILNAAKEDGIAFRIAYHATGAQQFSADVISKLAVGHQGKLAIAPIVDKSLIVPENVESAFVQAPDEPEAREERLHWIFGTWLQEGLAAKQLVASPKIKVIEGGLESANKALDELKAGVSCTKLVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBD5</accession>
    <name>A0A1Q5UBD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000456">
        <property type="protein sequence ID" value="OKP09770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBD5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="12835" checksum="676C121DEC50F432" modified="2017-04-12" version="1">MLKWGAQVCCVNQAASKFANLQGVNKCPWKDNGLVRDAKPAPIGESTDLAAGEVNYLQLGRWRTDRRPTDTKSEFGLCGNAVPCWPTVATLSIYATQVSSVVIIAVSALSADNYIFKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBT4</accession>
    <name>A0A1Q5UBT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBT4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBT4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="175" mass="19772" checksum="CABF9BD16271E20E" modified="2017-04-12" version="1">MGLLKLPYELLFEIIEHLEYGWDLTAFGVVNRRLHGLVNTYIYHEKLPGCNNDVLEWIVEKGNEDVLAQCLKANILTYVDRPIASGTLQKAIILGRDRIFQRVIENGGRDRDGEIRIGQWSPRPLEWAAEAGHDSVVKILLEYGVDEKDGGPLVAALENVHLQVAKALLDKYLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC75</accession>
    <name>A0A1Q5UC75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC75"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="3">
        <location>
            <begin position="68"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="34019" checksum="6E734F467B7742F9" modified="2017-04-12" version="1">MSFSNNSSWGHFFLKGKTLALCFFGLILLVLCLGSWAELPGSSIQSTILKRSTEVSDTAIWQPKSGVKWQIQLVDAVEDIANADIFDIDMFDNTAEKISEIHKTGAKVICYFSAGTYEDWRPDVKEFADPDFGSALEDWPGERWLDLHSSNVRKIMQARLDLAKQKGCDGVDPDNIDAYGNDNGLGLTEADSIDYLDFLASEAHSRGMSIGLKNGGDIIPSVIEKMQWSVNEQCAQYDECDVYAAFTDVGKPVFHIEYADEIEVNNKLKVRDVTSSQKSAACDAKSAENFSTVIKNMQLDAWVEYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCJ0</accession>
    <name>A0A1Q5UCJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_4382</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCJ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCJ0"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="153"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP10208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="420" mass="46242" checksum="60284C8242662198" modified="2017-04-12" version="1">MGSVAGLTPNQLQLIKASVPVLVEHGQAITTVFYKNMLAAHPELNNVFNVPNQRNGHQPRALAGALFAYAANIDNLGALGPAVELICHKHASLYIQPAQYEIVGKFLLEAMGEVLGDALTPEIKEAWGVAYWQLADIMIGREKQIYQESKGWTDWREFKIIDKVQESEEITSFYLAPVDGQPLPAFQPGQYISVQVKVPELECLQPRQYSLSDQHSQDYYRISVKKEKGLPATDSAAATHPGYVSNLLHDKYNKGDIIKVSHPCGEFFLSATAVKPNTPVVLLSAGVGLTPMTSILNTLTSKSTSADRKLHFIHGARTSRARAFKDHIAQLKKSHANLQATFFTSHPTENEQHGVDFDHVGRVDLSKLDASKDLFVDAPTTEYYICGPDKFMTDVQAALKEKGVAADRIKMELFGTGGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCN3</accession>
    <name>A0A1Q5UCN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCN3"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19303" checksum="7E8F230B1E05C93A" modified="2017-04-12" version="1">MTSPVYNYTVPTFIKGLETLTLILKNAEDYAKQNNIPLSDFVNARLYEDMKPLSFQIQSASNTAKGSVSRLAGIEVVSMEDNETTFEELYARINRTIDVIKAVDPKLFEGKDHTEFQTKLGPYEVTFTGQSYANRFGLPNFFFHLNIAYAILRSKGVPIGKMDYLKYFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDM4</accession>
    <name>A0A1Q5UDM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDM4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDM4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="325" mass="34055" checksum="D3FAFDD896779ECE" modified="2017-04-12" version="1">MASIQNQAAWLPYAEAMPLQVGPAPRPSPSPTEIVIKMQASPNFELPYPFILGQDVAGTIVEVGSNVKSLEAGQRVIGILNGNAANSGFQLYSTCLEILVAPIPDSLPFSEAVVLPLSVSTAASALYVQLQLPLPSFAPRSLGKKVLLWGGSSSVGCSAIQFAVASGLNVVTTASQANHALLKSLGAAQILDYKTPTIIEDLVSVLDEGDFVVDCISSPETQALCGEILSRIGGGKLPVMRYPKGKFPDNVNVAFVNGLDPGLVHVEVGRAIWGGYIPAALVTGTFQVKPEPFILRGGLEKVQDGIDLLAKGVSAQKIVVEISQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDS6</accession>
    <name>A0A1Q5UDS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Increased rDNA silencing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDS6"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="387"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="54799" checksum="F360DD45973FB134" modified="2017-04-12" version="1">MNGEIAAAKPRLAPPASRNNSALQGATIAFSNSKASSNVASPPSAAARAAVASTLNRHADRCLEMESENAPVVGSVRDKIGLFAANNTLPPPRAVSRGRTPPPSVGQIAARLAIERSPSRVQQATAAVAAAKISAARSASRMQSQAPEERRELRSPTPIRPRDTAKENPVNAMLRDGLALSEPESEPELYKKPPSLPPRAASVRVPATSPHPSVSSRMTTVSLDDTKPNLPPRTAPSRASTRNPVFTGTPLLRPSTPSMASVSGLSYHSSSSANEPGMDEEALSNAIVASSLASARASPATKLAPPPPPSRRRARSRSILQFAHSPKSDLSRTPSPPKGMPMTLRGMPKAEEADARRRHKMNLLHKHPHKHHEGDRKRWRREVTEKERKRYEGVWASNKGLLIPPDRRKTGGGPNGAEKGPPASEMVLNLVAREIWSRSRLPPAVLAQVWDLVDSQQIGLLTKEEFVVGMWLIDQQLKGHKLPVKVPETVWDSVRYVTGIKLSSVGPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE21</accession>
    <name>A0A1Q5UE21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE21"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE21"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000006">
        <property type="entry name" value="Cullin-4 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="512"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="882" mass="99392" checksum="5B10F564E614F669" modified="2017-04-12" version="1">MQQNSSADPDQRSGKRKSTGKRKLSDQGEASQPHSQRTISELLSSNPSRNTLSQNLSPSSKRTRFSVSPSRSASDHPVSPNRMYNFSGSPPKNGAAFVRSMAGSSANAPVAKAQAFSANGRQNNFSPHAGAKKLVVKNLRTGPRMNQEPYFDKTWAQLDAALSAIFDGQKPEISLEELYKGAENICRQERAALLAKKVQERCKDYVAGKLRDNLVTRAGGGTDVDTLRAVIEAWSVWHSRLITVRWIFYYLDQSFLLHSKDFPVIQEMGLIQFRAYVFADQSLKPKVLRGACDLIAVDRGAETSIIPDATLLRDAIELFHSLDVYASEFEPLFIDDSRNFVKSWAQRESSGDLASYVENSQHLIESEVERCGLFSLNRSTKQKLSELLDEILVTEQEAVLLSENDVLGLMRSGKKTALKQLYSLLTRRNLASKLKSAFSHFIVEEGSNIVFDEKNEADMVDHLLQFKKQLDDTLAESFDRNETLGHTLREAFGQFMNLGKKGESTAGTDNPKTGEMIAKYVDRLLKGGWKMPASQQEGAMADEDAEINRQLDQVLDLFRFVQGKAVFEAFYKNDLARRLLMGRSASDDAEKSMLERLKRECGSSFTHNLETMFKDMEVARDEMTAYTAFNRERSRKERPPIDLSVNVLSAAAWPTYADVPVRIPSVIATSINDFQEFYCNKHTGRRLNWKHQLAHCQLRAKFPKGSKELVVSSFQAIVLLLFNDIGADESLPYSEIQAATGLSDPELKRTLQSLACAKYRVLTKSPKGKEVETTDSFSYNTSFTDAKMRIKINQIQLKETKEENKTTHERVAADRHYETQAAIVRIMKSRKTIKHAELIAEVIEATRHRGTLQPAEIKTNIEKLIEKDYMERADGNQYKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEM1</accession>
    <name>A0A1Q5UEM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEM1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEM1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7429" checksum="F9BCF11EB60AE74F" modified="2017-04-12" version="1">MPPPESPLPPGVLIGEEISPVYNSKYFYMYFYPARPGETLANHYQILVKVGWGVSSTVWLARDLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEZ2</accession>
    <name>A0A1Q5UEZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable Xaa-Pro aminopeptidase PEPP</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Probable Xaa-Pro aminopeptidase pepP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_3550</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEZ2"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF1">
        <property type="entry name" value="XAA-PRO DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP11029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="465" mass="51150" checksum="2C13657E109B6C18" modified="2017-04-12" version="1">MPSVDEILAAKYPAKAHARRVAQVLKDKHGEAGVIYLEAQKTRLIEDNDEAMPFRQRRPFFYLTGCLEPDSSVVYDVKKDELTLFIPPIDPDSVIWSGLPLSPEEAKKLYDVDHVQYTTDVNATLASIASGQDGKTVAFAIEEQVSEGVQFQGFAQTNLAVLKNVIGDARVVKDAYEVALLRKANDISALGHIASIKAAKTATNEREVEAAFINTCIANGAREMSYHPIFAGGANGATLHYVKNDESLTDAGSQQRKGNLLIDAGGEYQTYCADITRVVPLAGTFPLETRQIYEIVLEMQNECIAVLKDGVCWDDVHALAHRIAIKGLLKLGILQGSEDEIFEKRVSVAFFPHGLGHYLGMDTHDTGGYPNYADTDKMFRYLRVRGNLPAGSVITVEPGIYFCRFIIDPVLQSPELSKYINTEVLDRYWSVGGVRIEDNVHVTKDGPDNLTTAPKAIAEVESLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF07</accession>
    <name>A0A1Q5UF07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF07"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="15974" checksum="CA526F8976A648EB" modified="2017-04-12" version="1">MPLRKRAADNQGPAGDTKKAKVNSGSDAVSNTDSNGDQYWEISKMRRVTVSEFRGKTMVSVREYYEKDGQELPGKKGISMTLDQFSALIKLLPDIEQAVKKQGESLPRPAYTGAAEQVDAEDDQEISNASPSKQNIEATSDEDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF60</accession>
    <name>A0A1Q5UF60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF60"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="169" mass="18233" checksum="B5F749DB192206A3" modified="2017-04-12" version="1">MTTLKSGDAFPSDVVFKYIPWSEESGDIKACGIPINYNASKEWADKKVVLFSVPGAFTPTCSVNHMPGYIKNLPQLRAKGVDIVAVVAFNDPFVMSAWGKANEVRGDEILFLSDPDAQFSKSIGWADEASGRTGRYAIVIDHGKVSYAQIETERGAVKKSGADAVLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFC1</accession>
    <name>A0A1Q5UFC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFC1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="300" mass="33555" checksum="BD52626D0092161F" modified="2017-04-12" version="1">MFEDFSFSSPSSRPGRLAVDADDRLMADCDSTLISPLSSRCPSPQSHRFRTLSRPRSSYFRSQQPPPTSVPFPYEQKRLSISTLTQKLHEHTLQAPGGDIPDQGRFRHNGARLSGRYSGYVLTPPDTDHDEDGRCDSSPSLCSNPSPTFIPPDFLSLDRMETPSLNPSIPDHRDVRIQRQQISQLQCNEGDIDAVRRTVVGEGSYNPDMLPDDCHPSSLPPRSSPRRRALTLHRSRFGPAESSAGEARGRRRSSSGAMQSHRIEKSHYTSHVGRDASKRGDHHGLRRKSMPPLLIEPQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFC2</accession>
    <name>A0A1Q5UFC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFC2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="5836" checksum="DAB1743A38659CE1" modified="2017-04-12" version="1" fragment="single">ADAAERKDAVDKAKAIVSFNLKNEKGEEASWYLDLKNKGEVGQGAAPAGAKADGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFR0</accession>
    <name>A0A1Q5UFR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_3154</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFR0"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000022">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="72"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="498"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="688"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP11317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="798" mass="89886" checksum="9FCE9944C15B9248" modified="2017-04-12" version="1">MAAALDEEDLSIPLAPTDRDRPRDRERERTSKATSSNPSAMAMPPPSRPTGRPDPTTQSPATMRDMQRLDQYQTVKILGEGSFGKVKLAIHQPSGRQVALKIISRRKLLSRDMVGRVEREIQYLQLLRHPHIIKLYTVIATKTDIVMVLEYAERELFDYLVRKGKCGDDEARKFFQQIICAVEYCHRHKIVHRDLKPENLLIDSTKSVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVLLVGRLPFDDDYIPALFKKIAAGNFHIPGYISPGAARLIRAMLQVHPVHRITIPEIRQDPWFTKNLPKYLEPPPEEFIATDVDLSKIDPRKVGSGKPVPVQHKIHQIAVSKLERSMGYDREDIEDALRHPEPSAIKDAFSIVVENEMMQTNSPTDDNILAQSVSSPPSKITAPAPAQRAPAAPRSQEQPAAAPARTPSVSRRPRPEETQQDDTDEFEPLRLSHVRILPTSLPYVHDQLMEQRDREQRARLEERRREAARAEEDRSGSERRELTPEEQAATARALKPHSRSVVDLDKLRFEPPIGHPITQQPKRSRKWQFGIRSRNQPYEAMLYLYRAIAAQGGVWDIQPVESGTTIGPDATSDKPKPLQSKYPELPSDYYIPKDPWFIRARLLKEGVKPPGASTSVYNSRSDLEELRRRFNISGISAPAEDKDKDIKSPTSDNGGVSAPSSASQNTGLPSISHGVWVFVDIQLYQLEENNYMVDFKCDGYQNVIRAHGDTEWHPISKRFMNKEKEVTSPYPFLDVASDLVAQLAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFZ6</accession>
    <name>A0A1Q5UFZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maleylacetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFZ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFZ6"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="165"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="37803" checksum="467338939BAB2B99" modified="2017-04-12" version="1">MDAFEYNPNPGRVVFGSGTLQKLPDEIARLQVKAPLVLSTPQQVGQAETVKDVLKGQVAGIFSEATMHTPTHVTEKALEYAKAQGADAVISIGGGSTIGLGKAISIRTGLPHICIPTTYAGSEMTPILGETADGLKKTRSDPKILPGTVIYDVDLTMTLPAAMSATSGVNAIAHAVEALYARNTNPIITMMAIEGTRALASALPEIIENPSSQSARSKALYGAWLCGTCLGSVGMSIHHKLCHTLGGSFNLPHAETHTAVLPHAISYNAPNIPEAMKQLADALPDSNGDAIHGLNVLLEKLKVTRGLKDFGMQEEAIDKAADIAVSNPYWNPRAIERAPIRELIRRVWAGEPAKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG67</accession>
    <name>A0A1Q5UG67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="241" mass="27527" checksum="495D1CA29032B0F8" modified="2017-04-12" version="1">MAQSSIFLFPIREISNDRVKLVPFNPDHHTRTFFRLSSSHPELYTHMPMGPWDLEEALKAEFYSQSQTQLLSFSNPTSFAFAIIDKTRPPSPDDPEGELAGTISLVRTSDTHLCTEIGFIIILPPYQRTHIAKNAVGLALQYSLEASENGGLGLRRVHWRTSTMNIASARLAEKMGFEKIGVVPWHMRFIKGKLRAKTGNGKDLPPRSDHEDLWRDTIDYSLSWERWESFAREETQKQIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHG9</accession>
    <name>A0A1Q5UHG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">High-affinity nicotinic acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHG9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHG9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF75">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54320" checksum="8D3C0789EE9AF44A" modified="2017-04-12" version="1">MAKPMDVEQLPSSHHVEGDVASKSELQVNVPEARQSLIRKKVGLQMPEMECCTDNNSFQFDGRVLPIVCTLYVLSYLDRSNIGNAKTAGLEKDLHLSNYQWSWVLYSFYICYILFEWTTVLWKIFPAHIYVAVLCICWGAAAMSAGAVNNLSQLLACRCLLGIFESIFGAGAPYFLSLFYQRKELGFRVSLLLGMSPVANCFASALAYGITQIKEGAPTVLFAIVVFLCLPDSPGSAKFLDETEQTEAVERLQTIDRTAKNKLQWKQVTSGLKDYKNYVHMTIHFCCNFSFSGLSNFLPTIIQTMGYTSVNAQGLAAPPYFASFLCCIIAAIVSDRWGNRGFVVTFFAVLGTIGYLILTCVTDESKTGARYTGIWFATCGIFPALSINITWLLNNQGGDSKKGAGMAMLAIFGQCSSLISSSVFPNKDAPFYTKGCALGCAFTGLIAILAIGLHVSLTLENRRRDRLYGEVSEHHRVDVTDGGDQNPGFRYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIB4</accession>
    <name>A0A1Q5UIB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000235">
        <property type="protein sequence ID" value="OKP12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIB4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="8318" checksum="C364216F7618FA62" modified="2017-04-12" version="1">MDRVDLQNVDYLSHVWQEEDIIATEKYIRVRKSNFQNYHRLQYALLRNWAKLRNNGLCCIALESAHTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIM0</accession>
    <name>A0A1Q5UIM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine adenosyltransferase 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIM0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIM0"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="304" mass="33662" checksum="29302F5E23AB1AE7" modified="2017-04-12" version="1">MTSTVLVTGATGLLGRQLFTTFQRSGVLVVGQGLTRAAPPTILKADLEKAEDIKALLNEVKPQIVIHSAANRFPDLCEKNPEQARKVNVEATRALAEECQTRGAFLVYISTDYVFSGKEGEAPYEADATPEPPNIYGQLKRDGELAVLEATKESGLGVVLRVPVLYGTAKSNSESAVNVLFDAVKNAQDENAGVKMDDWAQRYPTNTEDVSRVVRDIVIKYLKQKDHIKELPHILQFSSEDRMTKYEICEKLAEVQGWSLPGMIRNKQGNEPGGVQRPYDTHLSTKALVDLGIDVRTMDFIAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIR1</accession>
    <name>A0A1Q5UIR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIR1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="279" mass="32328" checksum="444683EEDE0AB390" modified="2017-04-12" version="1">MSERKVLTKYYPPDFDPSAIGRTPKHLRQKGPKVITVRLMAPFPMKCTNCGEYIYRGRKFNARKQTLEEKYLNIPIYRFFIRCTRCSGEITFRTDPKNMDYECEKGAKRNFEPWRDGKSGKYNETEEETLDRLEREENEQEEQLERDKMAELEEKMQDSKREMAIADALDEIRTRNARIARNEGLEDEVALDLIHNEVDEAKLREEQEDEEAARRAFMTATGERVKRVVDEEELPVPGPSQAKTATTSMPPPSTSFARVKKAKKPGLTSLGIKKKPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJX0</accession>
    <name>A0A1Q5UJX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJX0"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="25739" checksum="DFA42F002D01D233" modified="2017-04-12" version="1">MSTQDYEYLFFRIAKDNTIASSATKYKQLRLQALSVAPTSFSSTYEIESALTDAEWANRLSEYGRETFICAATPTQNNLSNSQIPEQSTWVGQLTLLGPQNPKDFILPEESGQKKPTEEKDQELWQMLSLFTLPDHRGRGLGKKLCQEALSYLASYKNSPRKVWVRLMVKPGNHATVSLYRGLGFAEAGKCTLAEALIANGDKDLLPEDISGEKYTSRSGLIMMLVIQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJX3</accession>
    <name>A0A1Q5UJX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3,2-trans-enoyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJX3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJX3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="32746" checksum="29169A05799F3E1C" modified="2017-04-12" version="1">MAFIAALGFYPKNGIGIGNVSNEQVITFDYKDRVAVVTINRSEKLNPLNRDLYYLLGERLREIDRREDITVTVIIGAGRFFSAGADVSTSRPSAKSSPSIRRELVKGFANNIYLTRTFYTHSKVLIVALNGRAVGLSTALVAHADFMYAAPHTFILTPFSSLGIVAEGGDSRAFVERLGIAKANEALIMGKRITCDELVKTGFVNKVVFAPSGKFDDSTGFLKKVLDEVEDSLGLHLNQSSLLKIKELIRRPGRELLDRQGGLEAFMGLERFLSGIPQEEFRKFRDLASGEKKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK28</accession>
    <name>A0A1Q5UK28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
            <ecNumber evidence="22">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PENSUB_1541</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EC" id="3.6.4.12" evidence="22"/>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UK28"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048459">
        <property type="entry name" value="DNA2_Rift"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 22 29" id="KW-0347">Helicase</keyword>
    <keyword evidence="11 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20 22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="25">
        <location>
            <begin position="576"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="DUF83" evidence="24">
        <location>
            <begin position="787"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2 rift barrel" evidence="28">
        <location>
            <begin position="949"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1139"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="26">
        <location>
            <begin position="1243"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="27">
        <location>
            <begin position="1315"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="128"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="201"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1592"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OKP12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1666" mass="184738" checksum="85A4B62652F87633" modified="2017-04-12" version="1">MATNNNNSYPISSNSRTKLNAFRYKEETVALDNTTSKNETKAVHDNKENQSSWLNGVVESMQTSADNADPPPQAVPLNEDTKPVKECPHTPGNRIPLADLISNAEDAFDPAPGPEVTPIDHVIWQHVPASSNPDASSQTPAGRRRKRRHSSSSAGSPTNGTSKKAQKEPLDLQSIQALFKTPQHDLAAELWNNYMDKNMVDGTDDLPPPRLANLLSSSPQTPASGRTSRDSSGLRRSISCAAEWPTSRAKRRRVNRQDPGSGRGIFSRTSSNVLDSGRNKSSRLNFLLDRIEKSLHPVPQVKMGPPNSSPLRQRMDAQRCRSSSPTMDRKGLVDADAAREALIGKSADNPEAAGGAILEDSESEFGDDDLDQDFMDLAEAAADPFVDFAVDRTDFDSLGSSALSNLAAEKLESSHSALESVFDKKPPAAQNSMNNETKPDDFDEFEDEYGDFDDDFADALVECDVKPTDASNPPIAKSQPAPKVDAVSVNSAPQVPAHVPQMSAHAAAVLSDDEFDDDFDLDAIEQTMKQTGEDAAYNLKSRKAIKRYQIVDTAESSFVNSRGRTQPEQVLSVKDEKTDARKVIILRESWFDTPCSKDSFIHLVGDFNSFGQCVVDNTNHMVILHPDHLISATVVADSVDCQRRAVLQDRVKVISQIEKPQAFGIIFHEVFQEALMANRWDLDSLRLLVEKVLGNHVEELYSINMTMSEAIETIMGKIPQVQAWADVFLQTKPKANSLVEDRNGAKLNLSIGKLLEVEEHVWSPMYGLKGNIDATVQVTCQDKDGLKNLVVPLELKTGKRDTNQAHRAQTALYTLLLSDRYDVDVTFGLLYYLELSKTLSIRGIRHELVQMIQVRNRLVGYIRERMQLPPMLKKAQQCNKCYAKTPCLIYHKLSEDGNGETSALGEDFEVFTKHLNQGDREFFRKWDELLTKEEGNLIKFKRELWTLLSNERESYGRCFGDVVIDPRTAHEDQNGTRINRFRYTFHKRKASPGFSFAESQISVGEPIVVSDERGHFALANGYVTQLSTSHITVAVDRRLHNARAKTIGFDAISNQSFRGIMEIGTDGLSELENPDEQMVYRIDKDEFSNGMAIVRNNLICMMDKDLFQSRHLRRLIIEGQPPVFKPTSSAYKLPDSESLNVDQKQAIDKVMSAKDYALVLGMPGTGKTTTIAHIIRALVAQGKSVLLTSYTHTAVDNILLKIRDDNIRMLRIGATTKIHPEVQQFADLAAIPKKTIEELKDSYEKPQVVATTCLGVNHNIFNQRIFDYCIVDEASQITLPVCLGPIRMARTFILVGDHYQLPPLVQNKAAQEGGLDVSLFKLLSDAQPDSVVNLEHQYRMCEDIMLLSNTLIYSGRLKCGTPQVAARSLEIPNIQALKQFHTDDVHFSEPKQEICLGPGHGRCWLNDLLVPCAKSLLINTDTLGASSLETAQGQGQRVVNHMEAILCTQLVEALIACGIPAREIGVITFYRSQLSLLRQSLRHYSPDLEMHTTDKFQGRDKEIVILSCVRSNAENNVGDLLRDWRRVNVAFTRARTKLLVLGSKSTLRDGNELLGKYVRLVEGKGWAYDLPPGAAGSHGFPSAALDSTQMSFQSPNAARSPGSMKSKMSPVVKKKPASREPLSPLGSRQPSSGLKRPAKRGVKLFNGTSVVGNRPILQDIVNDIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK67</accession>
    <name>A0A1Q5UK67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="18644" checksum="19522809E2612427" modified="2017-04-12" version="1">MPEITNGWANLYPCPSNNNEVFTCGTAGWASHVCDEQLGNYTWVRSNVTVAQLGVSSSLSASATATGTSSKTMETTTLTASCTASAEADNNATMKTGVGVGVGLGVPLLLAAAGFIWYYMHTRRQIQSLQQRLNEQGAMQLGPRGQYARLPPQELDSGKQTWPEIQSTHRSELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULV8</accession>
    <name>A0A1Q5ULV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULV8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULV8"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="187"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="242" mass="28575" checksum="26B4B594DBD26F89" modified="2017-04-12" version="1">MAEPPAKRARRVDSSTMWEKNDSHTVSAEQDSDHGRRRSPHPRDDRRDGPREDRRYRSRSRDRNDRRRERSWSRDRRDRDRRDRDRDGRGARDRMRSASRERGHDRRGYAGKGDKFRDRSRSPGRNGTKPRSSRSPPPRGPKGDRRPDRKDPRSRDDGRTANGLASASRHAEEMDVDFKEDADEDEMEAMMRKSMGFTKFRTTKNTKVPGNDIYGVRKEKKSEYRQYMNRTGGFNRPLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM23</accession>
    <name>A0A1Q5UM23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM23"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886138" evidence="1">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="37575" checksum="4FA733F89B9C66BF" modified="2017-04-12" version="1">MPAISRVVVPWAALSSLAVATAAGYFNDTSVCADSKGMEKCFAKAEKSYANCITGNCSGGSKSCYDSCNGDALCMATKCPNLGVDCINACGCVRATDQIDCTASSCWNQVYSCEYQQTAQDVLNLCLNFDMDQIPFWPAPAEAAGGCSCNIGDVARKEVQISAQLTECSNNKTNLNKMTEVGDMTNYAQACICCAESAIISAIWNVCPNTKPSEIGADYWYDAFLRPHHWDECGPYLEKYDCGSDLGFAAESAGDTHTFPKPNNLPKNGTETLFNTGGVLSTPVSGATFTWTDGLLLHAITAASTNNVVSVTGTVIGVQVASATATATGTSATKAGGAIVYSPPTWAGAGMAGILALVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM51</accession>
    <name>A0A1Q5UM51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM51"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06106">
        <property type="entry name" value="ScCit3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="465" mass="51318" checksum="B69FF9925FDA8956" modified="2017-04-12" version="1">MALSFRTTRHASRLAQASRPLFSARHYATAEPDLKTALKEAIPAKRELLQKVKAQGDEVIGDVKISNVIGGMRGLKAMLWEGSVLDADEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVPSTAQVRAFSRELAEKSTLPTHILDLIKSFPKTMHPMTQLSIAVAALNTESKFAQAYEKGLNKAEYWEPTFDDCISLLAKIPRVAALVFRPNEIDAVGTQQLDLSQDWSYNFAELLGKGGEKNQDFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILQMQDKIGTKFSDEDVRTYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVFQLVKKNSEIAPGVLTEHGKTKNPHPNVDAVSGVLFHHYGFQQPLYYTVTFGVSRALGPLVQLIWDRAMGMPIERPKSINLLGLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMS5</accession>
    <name>A0A1Q5UMS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMS5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMS5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="2">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="3">
        <location>
            <begin position="480"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139414" checksum="B7B4BF7862E62D5B" modified="2017-04-12" version="1" fragment="single">MDEEQFFTRSTRELTGLFSQTILPSPVVQWILPARLRSNNHNDVVFVGQRRVQIKEASTGGFLEDVTEKNDFDHPIIGAKVINVNTELPWETQLRTDGADDQMQDDSNFLDRLPSQLLVLSLEMRELQFLYCPTTGDDKFVTFRRPLPVDVDLAERFGKHIAVDPKSRAVAVSASSHYFGLLLLKSSREIQQQMIEGKLDPIKSEHFYSCDGTIQFMEFLYPKAADDKRIILLIVSSSAEGSFARIFQWDDRDSTMLRPEIVEFKLRREDRLPTMIVPLTKESSFLVVTSISMAVYPSDSSHPRPIRYPLIAPDATFKETSLWTQWARPARNWLYSQKFDGIYLCREDGWIYYLEFGNEGGLETQTSLGQLHCDVDSAFDVLDVGHEGGDFILAAGSMGDGGLFIQEARNKPQCVQRFLNWAPVTDAVMVPSKTHENVQCDVSRDRLFVCSASSASGGSALHELRHGFEAQVGFSVPLDDFSSIRDMWAFSDDANQGVYVMLSDPMSTLLLYMNPSLEDGISALDETETGLDNAQTLAAGCTPTHILVQVTQKATHLFAPDNISSNTSIPHQPGSVVVAVAVDGPSSTLITAVRLQNELNLTLTRIVMNDTNVGLDVIQKVKIDKEPVCLSLQTLGDTTFIFMGTSDGTIKVFHIENGTIKFLLEASVSIDREDDISRAIDSLAMIRQTDHGVLRAHLLCGLRSGVLVPFQVDFNAPTLIGLNQVSPKHVGMTSLRLQSHGAFAMLICDHELWRVSSSADGVPNDCFLSRIWITEQSNPAYFPTGIHGFGLISQTSPEAGLPIGPLFCFADRQLLICSLDRERKIVPRRIGVPGTARKLVYSPHLDRLILAYDKIEVEEPSRPGDITMRSCLAFVLPDAQEPVNPLDQPLAPRASPGERITCMMDWMFERDGHMYHLIVIGTGLSATIDYEPRGRLILMSAPRDPQDASQVRFVTKHVQECLDGAVRSIAAYGNTLLICTGRIIRPVAPSGASIRWASNSWQELPSPAVAITVSKPFVYVTTARHGFVVLEVLDDGNGLHHLKLRAHDSKPLDGLTHYVTAGEPSLAFLSTRGGNVRAGRLSSSTELRTTQVFVPPAPEEASVWDSVLQFVPSSKGNMFPKSPRERGGAIYGIALNGSVFRFSILREDETRLLLALQDLCRKDEALYKSLAAREKRKKPTWADPKKDNSQVDGDILIRLARHRADYLEDRIHALDQKRGSPIYEPFMRNAALKALGPSDNYAQQVVGWLRQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN57</accession>
    <name>A0A1Q5UN57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN57"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="494" mass="56477" checksum="BA30336FAF0504DF" modified="2017-04-12" version="1">MTRYAPLTTDLEHVKATTEINPGDTFIVRFKNSARDHKTDIWIGVRLTDDFEDVPGLTNKAFSRWICISDFFVLGSKIPGIFTRKIEGRDYRKDIKIYRELVKIADKKPGMDFWRSMAKKELLEKGKRIKGLGLILPDGFEEITRGISIFSGGNREESDSNSEDEIDAAELEGEPPSKLQALTSSFSASRALAESSGQNMESPRSLTFPGENKQFQSLHAGKHEKVRGSRLGKRKSAPGTLPAQDSQTKMEKEPTEDINNALVDLQNTLFERTWTLSAMIEHILLEKESSQQLLAILRDVCTIEDPELGKLISFLNTSEFSPQLLKVSNARPSTCEEAEAFEIGDCLGIHRQFQLQGVTNSEELHEQIIQLGCLYYYARHLNMVDLVEKITFKLQAAWNSYPGLSQLEPMLGVTAMAFKDSHWTDHLQGWLIKFIADTQDLIYYQCPQRFWEIMRDRNDLYSSVTQMRSEFNRKNPERYANPRDQIRQRGIDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNR5</accession>
    <name>A0A1Q5UNR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Helicase SEN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UNR5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="1897"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="1923"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="1941"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1840"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1974"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1477"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1840"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1974"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2002"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="2072"/>
            <end position="2081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2120" mass="236383" checksum="02A42704D0225CDF" modified="2017-04-12" version="1">MEFVDAIGELKALPEGTHLLCPRRSENDYGRYDDPSQVDEHGKSTGDIVAEGKARKEKFLLSMRILAYNAEGVEELQTWVLSKLDQCLEQCDLCIKQYYTGKVWLMDQLKELYQDEDIEEFAQRMDEWDVKRITRNLATACAQLKKVPPQEINLSVLDRAALLSIFETLSCEAMLRSDQLLQEHFDEPFKLIQSKRSLKISDYVPAVTRFLFDSNQARSFWAISTWTRYTRPPTSEEFEWAIRDGLLSALQAGSQAANQLPPQLAVVQRLWRGMQLIVRKLDKDQITHNLRALDIDPCRLSVDHLHLQTPGLRFLLNTIQILLEKAPGDFWDAMQTISPQAIIEQIFANYQFRAFLMQTTEGEAYEKSALKDMLSWINPFMASLKGHHQPSACRYLATQLLQRLQDDQYPNLARYHCFHVGLNSLLSTLRRFTDHEASRSSVDSVVLKETMDVVVATINVILNPPVFNIEQGRQEEIKSLCMDVVRNTLALECQSLKSDYEVILKHGTLSHGVSTYSAPVWEAVIKHLRQDNLALSTAALLGVLPLVGLEKFPAKGDGTKEKTHFNMIYGHLTRLSCQMIERLADFPPEHLKPLFQSQDTSSALISTLFAADLNTYQAAVDLIKNVSGQFARRDAISYLLESFFTTSMYGMSWSFRRISNMKTFAPAPRMLHTGTDIVEILCNSQTGMLRTRNFVDRREILSLQKLWEFLWQSLTTIFDETEAWHMRGNDKEVMLDFCRDTIQFANFLFDQYGVFLGVVGGTDTAQKSVSEAFIKSPTTTMSAMVKWLRLKDEYLATSLVALVSKILRRLGSLDVTTVKADALSFIEGTAVHGTIKTILTSRDKAELVRSLEAYTKKPVVTASTASLKKQSSITSFARRPNDLSSPSSPSSRVPSDDEFEDIPDETLLDLSRSVELNKNRLALTAKQKGSSPLGMPASTALQTRPGMPKGPMAQRLKNDATSVLSFREKREREKEAKRKRDMAELARLKKNMPARGVAEQTAEQGSGLKGIGVKGKDHSIPLDSMMVSSGSDSDTESEDELDQELFGAKPKKSDAADPSEQKKKPPQQMPLRKVKRHRSMKDMRARLSPDLSSLHHQILSWNYFATGDLPSGDRTDYTLVSNSFRSPQDYKNTFEPLLILEAWQGFQSAKDESASSFRPFEVKVMTRLTVDSWIEVSTQPLGLPSKDFFISEGDLVLFSNAAKPHENENAPHILARVAHVNRKGGKLEVTYRMNPGPNKFLQSLCVGATAFGVKVTSLTPVEREYGALMALEYYDLCEEIVLAKPSPLLTYGDSTLQPYMDNYNINRAQAKAIKSAMDNDAFTLIQGPPGSGKTKTITALVGSLLTNVLSKVAVTIGNSRPASSRKVLVCAPSNAAVDELVMRMKEGVKTRNGRLEKISVVRLGRSDAINAKVLDVTLDEMVNARISQSPSTSNNVDMQKLYEEHKTTDTQFKDLRTSLDDCRAKGIAPPEELEREFELMKKKRTQLSADIDKARDQVSTLARNADMQKRRIQQEIIDGAHVICTTLSGSGHDIFLGMNVEFETVIIDEAAQCIELSALIPLKYGCSKCVLVGDPKQLPPTVLSKMASKFQYEQSLFVRMQKNFPKDVHLLDVQYRMHPDISAFPSLTFYDGKLQDGPDMGKLRVRPWHQSELLSPYRFFDVQGMHHSAPKGRSLINYAEIQVAMQLYDRLVTDVKDYDFANKIGIITPYKGQLRELKNQFASTYGEDILKKVDFNTTDAFQGRESEVIIFSCVRASNNGIGFLSDIRRMNVGLTRAKSSLWVLGNSAALMQGQYWRSLINNARERHVYTEGNIPKLLQRPQFTGYKEIEMVDVDAATPTSTTVAPTAPTAAPINPPTAVSVAPKPQPVVAPAQSSTPTPRPDGPSGGAAGLDETKMCGVCGSNEHFTHNCDNEEAQEAARGQCYRCRGFGHSKFHCTAIRCLECGQFGHPAIKCAAKPLPKHEKARIANEERRRLEQQKQHAERQRQRQMGGHDPKIPTIAVTTNSSPGPNENAGIKRKRNEQSGDGPKASRPRTGPSGPPSNAPKGPRLLAPGLSGPARNGPGAKKPSASGGGGSGGPSASGSNATEASHPTQPKPRPPIMRKKEVDPFIRRPKPKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNT0</accession>
    <name>A0A1Q5UNT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UNT0"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1548" mass="167053" checksum="EF138B4A1561EF22" modified="2017-04-12" version="1">MSSYNMGGRRMPPNDPFPPAHTSHPGPTNSTPAYGPRLPRPQLARPSNYTTRTDRAASLSAAEDSRSISALPPVPYQMSNHANRLSLLPRPSTGGTGSSPSPASTVSPHTPASSIPSSLSASDLTTPSPFTPSYQAPPANPPKRARNVLRRRAPTIGRHVEQNQSQKLSLVIPATVQPVDSREPRLPNLSDTYSAEPSSSSQSVSDRMENSAVDTPKIQEPVELASLRTTVDTQNLPPPPVPYYPSASTPSTRYSESPGMWSRGSTPTSLSSYSPGIMHSSKITRMRQRSPSQTRLPVFSPPSVQASPQSAQVEQADSKSQRSGLSKRSLALGSATITSGKGQSNAKSTPGKLQGPPHSPPPRKSSVNFSPPRDAPSKNPDIDIDQARKEVEEAERELFNSQRPRAPSISETSVPKVPKTPPRPSREGTHRLDLETSPVIQSNLPYLRSTGHKRRESMERNRIAQPPSAVASTDSLPSKNLSRIPSREAGSPVLARKSPKTLTKEPPKEKVDAKKPAAQKKFGLFSKKSKPDLDTAFDDQARPTRKGPAAGTGHEGYGKYSQRGRKSSASSASGVRTRSTSTTRSTPHSVASSKGSMSSSRPDLDLDDFLAARLEPVFISGGGMDGATLSRTVSEQSISSMSVTSSTLPRPTPLTSSTVQSTESLATSTGTFGDAGPRSESTTSLEPMRSRSPEKNQTPASRQQPKSRMPVPKGKRTGLYANTDATRTSTSLSSNTSSTVVPQRSKATPAATTKQKEPAKLEPPQPKKGKTSRWNLFQRSRSNEPSTTGESALAPPSHTAQLHAAISPVLNSRPIAHYALVDADSDELDDILNHVEDSPPTEEEPYIVPVEVPASLNIKKRHPSILLPSPPRMHGEFDRDNRPSPRTAMFNQNMMDPEPQSSPQDRRPRRLASIGRIPQVVSRRDRQHKPAMHSFSRPFSTSESPSVMAPTPEGTSEYPGLGGISLADIPSSKPGDWGYGFNPAFSAPEAASALEFLAGPYSAHELIHFSPHKGSPSSGSSGALAAVTAVVPKPGTAPTEDEVWNEYDDLIDVLSPEEPKSEETVKTEEDDRFEMATMASKALQDELNNDNSLQPPPFSPAGGSNRDSGDSVHLRRSRIVSALHSSIAPSTQASYSNLIASYGDPEVMYSPANPTQPSLDPVHEQQSTFLQSLAATPAPKPKPYEFKDFPGCSEREWDAVTRTNMRSASLMTSRWLSFGRVLFSPAHNHVKSGTHGRILVIDGLGNDDWSFYCSLTYPDAEVYSLSGRPVSTAIPHPAAWQPPTNHHTVYHAGLQNPLPFPKDYFAVAVLRFPAASSEAIQNNILQECRRVLRSGGYLEMSLLDRDMVNMGVRTRKAVRRLKEMTCLANSSISLAPTSDSIQRLIGTQGFDNLRRCMVRIPVAGMVVRSSGSTTSSSNKSLSASATTQSTGFSLPAVSVSTAATGSQSTQTASKSSVSDDNISLGDLLSDPSPSAANDESIAKIVARVGRWWYTKCYEEPALHDTGDIDLSMWNDRKVLRECQKRGTGFRMLIAYAQKPSEKRRTASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP13</accession>
    <name>A0A1Q5UP13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000107">
        <property type="protein sequence ID" value="OKP14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="452" mass="49765" checksum="25147DB4BE367851" modified="2017-04-12" version="1">MREACPGYRDEWDLVFRDQTDHTIKRTKEKRARSATAAGANDTSPTRGLSPSPDEIGINYFLRNFVIGSQSSSRGYLNYIPSVYVNDGEHPTLVASLAAVGLVTLANSTQQPELASHARAKYLEAIHNINTALASPAESVKDSTLMSVISLGLFEQVSGFETWVRHVEGAAALVVARGKGQFSSPVTIRMFNQVRADLVIASLHGTKPIPQDMLELQEEAAGHTDTASAFWQLGVLGTRCANLLFALRKFTGEGPFADFLEEATLIEHDFQRTVESLAIEEPYITTQEPRGDPTIILNGRVDRYRDIWAIRVWNNSRNLQMILCEIICFLLNTILGQNLAPALQRSMSRRLQETLQTLSKLGNDFLATIPQAMELASSPSDPRPSVDLSFRGNISGGSMLTWGLYMVGKCAVTTKDTRKWIIQRLQSIGSNTSTSVALHLAEDIIKIDQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP27</accession>
    <name>A0A1Q5UP27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_66</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP27"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="328" mass="36033" checksum="623CBDDB5469FB5D" modified="2017-04-12" version="1">MSLLSVPTELLELILEHLDRQSDINALVQTCHHFYDNFNGALYRLNVKLFSRSALLWAARFGHEGTAAKSLKERPFVEIYDENGLTPLLLAINSNCESIFRRLLMLTGLDLEAKGWVRRTPLATAASLGRQEMVKLLLEKGADLESRDQDCQTPLILAAVDGHEEIVKLLLDNGASLECKDILGQTAVSWAAERGHAKTVELLLVKGAVPDSSDNYGRTPLSFAAKNGHDTVAKLLLEAGADPNSKTMDGNTPLIYAAMYSREAVAVIRLLLEAGSDPTIMNNGGLTAVLLASTDWGTKDPNIVVVNLLLQETTRWMRARAAYYNCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ06</accession>
    <name>A0A1Q5UQ06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclease PA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ06"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012254130" evidence="8">
        <location>
            <begin position="21"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="341" mass="36247" checksum="49C910739F419686" modified="2017-04-12" version="1">MARLSKVAIVTLGSLSGVNAWGTLGHATVAYIAQHYVSSSTASWAQGVLGDTSTSYLANIASWADSYRATTAGKWSAPFHFIDAEDNPPTSCNVDYTRDCGSSGCSISAIANYTQRAGDGRLSTANIAEAVKFLVHLLGDVTQPLHDEAYEVGGNSIKVTFDGYSDNLHSDWDTYMPQKLIGGSSLTYAQTWANTLIGEIDSGSFKSQAASWISGDTISDPVTTATRWASDANAYVCSVVMPDGAAALQTGDLYPTYYDSAIGTIELQIAKGGYRLANWLNLIYNNDIAKRDLEGFVNKARSEAPDLMGRDLLPAPGPLSRAQLARDAMGGDCCGSARHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ59</accession>
    <name>A0A1Q5UQ59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase YusZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ59"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006114">
        <property type="entry name" value="PRK08263.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="28968" checksum="BF03A532D8BD0880" modified="2017-04-12" version="1">MKVWFITGSSRGLGLAVAEAALNNGDSVIATARKPEQLANLVGKYGADRVLPVALDVTNNDQAIAAVKTGHEKFGRIDVVVNNAGYANTASVEDIDIDDFRRQVDANLFGVVYVTKAVVPIMRQQKSGHIFQISSVGGRLGSPGLAAYQCSKWAVGGFSTVLSREIAPFGIKITVLEPGGIRTDWAGASMGIPPISEPYQQSVGAMVEHLRSMSGNEPSIPSKIGQIILKLLDEEEPPLRLVIGPDAVPYAKSVGEALAASDEKWRELSLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQL3</accession>
    <name>A0A1Q5UQL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G1/S-specific cyclin CCN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11507</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQL3"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000065">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="191"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="195"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="430" mass="49170" checksum="19F25CDBF42C4058" modified="2017-04-12" version="1">MDYIRPRSGYQPCDTFFIEDDYRMQAEKQAKQEHDKLMNRERQHAMATQISRITSVEFRDDVLQQMLEMDAQTLPDVESIDIQTEIQWFMRPYLLDFLIEAHTAFQLLPSTLFLAINLLDRYCSKRVVYKRHYQLVGCAALLIAAKYNDRKDRVPTVKELKSMCCSLYDDDMFIQMEWHVLQTLGWSVGHPTVDEFLSIALLDEPYDAEVEHMALYILEIALFHRDFVSKPSSELARAALALSRCILNRPQPRHTDWAAQYDSTTLVGLSQQLHQPSTVVSRKYASSHFSRVSKVLEHFLARQASMVNYPRCTPPVETPVESKPYTGEMGLATPQKSQQLTAVPHGYMTPPITPENGPFAAQAQMAANQEMARGAPACSPSPAPEAEMQYMHTDAYQQQEAMYLSQQSQQLPPFPPQSQMALDPTYQAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URC3</accession>
    <name>A0A1Q5URC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3421</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URC3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URC3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="48093" checksum="1E7A83EB9C36F277" modified="2017-04-12" version="1">MADADEDAVRGTTVEATQIEVDLSDETQDFRLLNHLNFLTDTSSSSLPRRGEKDFEPNPTEFQADVLSASRQAMHNALAHPRLHNPKTQVIAIYAPEGPPPAPAVTPGQPSRGASVSPDACVYVPSPKGQYFKSMGQADRKGVIWLLPEEALYLLERGSLDIRWPTSITGGTTVGEGSEEEELSIPMSLQAAYTCLIGRGGLTLERFTVFSSLKRIGYAISRAPGWDDSTEVDDSVDEHSRDSYTQPLKRGAGLAGILGSIFNWINDPKSTSSMAAGPVIGYGIHRNYADIYKKLALIPWYDPTLAPTRNTLNTSAPFRVIFYVYKPSTPIKKSALPPPDFRIAVINTREQTTAPTLPELSALLESTPLDPPRGEKMERQMYMRLRHGYRNVILAVVDQGVTSFLRVADVAFGKERLFEGSSAPTGPKKGGNFRKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URK1</accession>
    <name>A0A1Q5URK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URK1"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="9"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="437" mass="48673" checksum="2E88186C3261A576" modified="2017-04-12" version="1">MSGKTRADNWVDGLRGIAALTVVTYHLCSCFANWLNSPAIEENGPVSLFQYPFIRLIVGGRMAVALFFLITGYVNSFSTRKHIRNGDTSFALLNLSKNTFTRTGRLVAPTNAALFMGWIVCQLHGYRLAAQTDSFWIRVGAVPPGPTFGSAVWGLLQNLTLFWHGGVGIYDHTYWTIPFFLKGSMLVYVTLLGTTLTQPRYTKLIIVFLYLFAWSGGQALMELNIYAGMLLAELNADYGSRATSLLSRPFSALMIIFGLFLASFPEEHAEWRPWSNAVNSVAGVLVPSGGEINRYVISVGTAFIAFGAFFSRDARRILSTPVMNFLGRISFPIYLIHNTLIRTILSWLIYRDSAMKEGLHPVDDQGKPKYLERGSALTFAIAIPMFYMMLIYASYLWTIYVDPACGRAVFWLSKKAFGEDDGSGFTKEEALKGSLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URL1</accession>
    <name>A0A1Q5URL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URL1"/>
    <dbReference type="OrthoDB" id="10477189at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24586" checksum="05B2E69D3C234C50" modified="2017-04-12" version="1">MAIISLESGVSALKIDAPLPNVSADEHAKAWRGSAYQFTDKNTCFYCENPGHGSNQCKYLNLAVRNSDWHPDPKLWVYKEGESNETLGKHRRGPRRSKKGNTDDRPQVIKTKPSDIVGNNIQDASFSVSTTPFEIVGNSAQGPPLTVSIRPPRIAGNLGHHTSFSTQGSLGFTNAIWNFNLVPLPTKIAATWNFPRHRWAITVGNYRHIANSKDCFIDYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URR4</accession>
    <name>A0A1Q5URR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URR4"/>
    <dbReference type="OrthoDB" id="4364380at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="33481" checksum="020BC90B8EBDA48C" modified="2017-04-12" version="1">MATDFQLFPSLPPELRLHIWHIALTTSWSCTTIKPLRRYNYKSTGTNPTKPITQVCHEARVALKETHTYIEDLGLFNFPKHIFFIRDLRYSPALPRRLQSRYSLFSYIQHIVINPKSRTLMYEIIEFLAEVATDLKSIVVVAPWFLPEDTDLYDDYKDWIAPYEDFGEVFVRSPSEVNLVNLISAIECGEDGGECRLLDGLSVGEYKARLDRAVRRLPDPLPDGLQFMNNAYWRTRGMLRTVEAAVGKFATPPRLYLQTVANMRTSGEDGAEGTSPLNTERKTGRVGAENVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNS2</accession>
    <name>A0A1Q5SNS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNS2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNS2"/>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="843" mass="90156" checksum="37363316BC9DECAE" modified="2017-04-12" version="1">MVGRRGKRGAPAANPTPATRSSRNPPASSQPSSRARGRGRGRGRWANHWANRLLPGRAAPADDQGESPRRSHILKFKLPSLRKLELGPSSTSSAPVQADAPTAASTQPETPRGRRSKRAMAVPESSRTTRQSARLKPSEESAIAQEASPVDDAAGVVDGDADAGANADADATDLEEHSTSPEQSQSEDVEYAPRIRLRLSPPKPPTQQSSTDQVTDPDHPQDSTKVPALPDASQQPSQPVSQKTEGEHQSPVLPAPATASFSPRLSRKRKSSELKDEFESAEMPDPSATATKKLKLEDSELSAHSQEQTGISTGIFAGPTAQESSSPADNGTFPDAPSVDPVPSIEDPAASGRGRGRGRGRGRGRARGRGSRGGAGGRGGALGPTRGAGVPGRGGRGRGRGRGSAAVAIRRGGKRIEDEIWDSESRRRTPSPVPATQPLKDRAEELAALFKKVGQAQQLALSVLAERSMQTIARDKNAHLDCPEYDQVMRDLAEEQRRALTRYRAQYDLKVESAEKVHQGNLFIIEQRTKAQLQNIKEEMFLAARGKYIELVAGRRAAEDDEHTETDGSDGESDGPRYLFRIGKAGLREVERGFIAEAVRVPDGAAAYERGEQEWEDFIMKVRLGEDLNPQMQALDYSIEASLDSINRTVESLLEAARTVAEESEGPRSYDGAADVSKALSVLADTALSDPRPAHYPQMRPDQHMTGHHALLPQGHQGVNVAVAPPPPPGMTHGPTDPRSFILPRPTPTQQPRRLLPARSPLGMGLPDPFAMNGPPQLPPPMGSNFQRLPLPSWSHGAPQGGVQQPGPGHGPGSTGSHGGPAPPHGGGPPSLYYPGPQQPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT8</accession>
    <name>A0A1Q5SNT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF33">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO89642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="515" mass="58101" checksum="363912E14DD02AD0" modified="2017-04-12" version="1">MENQIDSPRKRIRLSFACNYCRSKKTRCDEEQPCRNCRQAGVECITTDKRRAGALVSNRRRTVPAESPSQQGIPRTPDSHLSAATPSASQDRPRLWSQCWGREGWQTGRLPLMPRFVGASTVELMTEWLDMAFYRLKGAKTHALSPLVNRNFAAGIPEKAPELPSPAELEAYMSNFSDTLGQLFPFLDRGRVDSFFTTEALTSTVHPTQASGVHQRALVYLMVTAGMMAMPASEGSQSLISSYIAYCNSLLGHIVATRSLKSVQAILLFAMVLRSCDKIAWAWDILTMGVSMAQSLGINQVRSPSSTPTGSDNQEYRTWWSMYVFEKILAFELGRPSMVWDRDLSGTLATSVLVETQHDSDQLFWQASISLANMLHELQERSAKAWRREAWLPQTVEQAIEEKLQTGGELLVLLCEWQQNLPDDLNRRYYQKHGTALNFDEILRDLEEYISHLLDDPMPNQLELTSLSTTNPILNDSLVDDSIPFTSLATQWGPSALDWGGWDWNDLSHLFQHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP03</accession>
    <name>A0A1Q5SP03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP03"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="91" mass="10173" checksum="DC8F62C3A28EAB31" modified="2017-04-12" version="1">MKLGADHPDTLTSMNNLASTYMAQWRWEDSMACPDFRRSSCHRKIPLDLSIATVDVCQVSQARSREGHAGSCNVERILSDKVLFDGKVGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRM4</accession>
    <name>A0A1Q5SRM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_13368</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRM4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRM4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="62"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO90651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="409" mass="43666" checksum="7A83889FF0F34E1F" modified="2017-04-12" version="1">MPDQSAVYIGTAFIAGVSLALVCREVLYPRGHPEKSVDSEPASDALVARSGPPAIVEGIQGCIGNTPLFRIKSLSDATGCEILGKAEAEKKGILTPYSGDTIYEGTSGSTGISLATLARAKGFLAHICMPSDQAIEKSNLLLKLGAIVDRVPPAPIVEKENFVNRARALAQAHTESTTVPFTSEENGHLETHELKVRGRGFFADQFENEANWRAHYAGTGPEIFSQCNGKIDAFVAGAGTGGTISGVARYLKPLLPNITIVLADPQGSGLYNRVRYGVMFDLKEREGTRRRPQVDTIVEGIGINRVTANFEAGKELVDDAVRVTDAQALAMARWLVEKDGIFIGSSSAVNCFAAVKTAQKLGPGHRIVTVLSDSGSRHLSRFWAKAGDVGGAVDTKLEDVLNARDEDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRP5</accession>
    <name>A0A1Q5SRP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRP5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRP5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF28">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="24180" checksum="6090640CB562A0AE" modified="2017-04-12" version="1">MKFQDIVVRDGGMPIGEYPAVLGHEGVGIIREVGTGVKDNSLSPGDIVLLSFHTCGQCGPCEERRLGGCPHMTEANFLNTARSGDRGKTPISLPDGTHVHGQSASGLGRATAFAFAKQGASVVCADISPLSSHGQATHGVIMQEGGRCSFVKADVSSEESVEALIENTVPDFGKLDIMVNNAGVAPEAHSPKPIWKTTEEVFDKTHRINVRGVFLGCKYAGLQIVKQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS52</accession>
    <name>A0A1Q5SS52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS52"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO90824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="35678" checksum="FC2A293E9366B3B9" modified="2017-04-12" version="1" fragment="single">MSQLLPIPTMLDRRAEAHPDRVWVRHPVGTSYTKGFQAATYGQMRTAVNRVARLLKDKLGESQSFETLAYVGPNDLRYHIVLVAVIKLGYKEQMFFPSPRNSIVAQKELIARTKCRILLTPDPEPPLVTGFVRENTTSTIQIPSLKELFKHDDTIIPYVYVYEQKPLDVIRDQPVLILHTSGSTVRRSSDFPDAQSVFALSPDLEEFETRDLFSPHPELPDLWMHRGRRDDLIVLLNREKTNPISFEAEITAHPDVRGALVAGNKRVEACLIAESIPEALQQVAEDTSAKENFAHKIWLLLRKLIAIVQLMPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5STY2</accession>
    <name>A0A1Q5STY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000747">
        <property type="protein sequence ID" value="OKO91468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5STY2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5STY2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="155"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="37655" checksum="5E87F22960369F1D" modified="2017-04-12" version="1">MLINHFFKANKSFSYEALRAAGYSNHGGADLGEVIAICSKIRHGNEDDWLHEWQKAAERAFSNAELSEFVKNQKSAYHGYLRASNYFRTAEFYRRDVDEDEISNFLYGRSETAFAKAMTLSTFTYESISIPYEGTALPGYLICPDSTKKPRRTVIFNGGYDSTMSEGWFAIGAAALDRGYNFLAFDGPGQGAALRQQNLHFRHDWENVITPVVDYALSREDIDGNAMVIFGWSMGGYLVARGATQEHRARAIVLDDGVYDFGSAFRAHQPSFIQKMVEQRYDSIYNWMFHCAQFFSTGIRWALQNGKWTFGEGKLRNFLRGRVSELDTGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUN6</accession>
    <name>A0A1Q5SUN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUN6"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="5">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="3">
        <location>
            <begin position="439"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="4">
        <location>
            <begin position="667"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO91616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="82469" checksum="36014B4DB3793049" modified="2017-04-12" version="1">MEDIDDDYFSDDLDSLPPGTLYELEQNAFQATQGPATLQQHNAPLAPNEPALVHTRHTTATLKPPPRLHTGLTNDYDTLEVGELEAEVYDNVEAQQAIAQAPAVLVTENGWPADGGMDDMMEVDHEYGQANAYEMNARMEQLEQEREQMRRELAEARTLAETKAGEIAIIRSKQARMAEEYDRQLAALRKAMVDRETTHKEAVDAAMSEGKMLATENLFLQHDLAEEVHQLRNYKTKQRAAEKGPPVTPKKSRVLPFRDGFDDDEIAVVSPSKSAARSKRGTPTVPGKRKRQASVDSPAPLLLNPAGELNMVDAPTDNSGTVFDEEPKSRESGAHDHLMKRILNHRMLPDQQTDIEAFARLHFPSEPHKTLSSIIMDELARIDMGNFVLEYIYTVGQLWRRGLTERFYEPVPRFMSIARYVLMMDEAPLPDLITSLVGVLQDSVEVNAVPRFKYSPAAREKARIPRSTPQSDLHLEVDSTEALRLLYYISCQLLHVKGALDSFWAHIRYTFILVMLHGSQPLKDIMVILPLLSTSIRADSFGPIMSSEQDQADVQKWIVDRLSFMLSEAAMPDEGCEPYTAYDICAMRLEVLLLLESLAFNPAAPSKEHGSAIIAAHPTALPRLFRSMHDELDALYSSPPEQELRVAMVNGLMRLIFGVMRRHGPSINMQEKLASVSGSKQKHLVVLTRLAFCDGSVLEAGIDDETVDMAHELLEEWTNPQEAESLAEAFPSSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWC4</accession>
    <name>A0A1Q5SWC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWC4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO92318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="34991" checksum="291B67A68E047568" modified="2017-04-12" version="1">MTIEVNEDTRGSQRKILFDLGLRKELSSHPPAVERFLVESGWDLQVTKDIPEILKEGNLSPTDIEAVVFSHHHFDHVGDLSQFPSTTTVVVGPGFKNAHLPGWPVNPESSLIDDDWKRHNIREISFDVGPEELFIGGFPAVDYFGDGSFYLLNAPGHTIGHLAALAKISLASASSGEHPSQHPRDKFVFLGGDICHYPGVFRPTESSPLDTEAQAALYTCPASFFLDVHPEKSCEKPYYRMPAHCTVDEKAAGDSIRKLCAFDANEDVLVIIGHDASLIGKMDFFPKPINVWEKEAKDTLQWAFLKDLCQNTIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWN3</accession>
    <name>A0A1Q5SWN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWN3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30546" checksum="28D4672F3563F8BF" modified="2017-04-12" version="1">MHPDSQLETAIQNGFDPKSLYAAELTQVNEPARTILEIYSKIPAAQILQHVKDLFPYACIGQASFLELSIASSPCYPEMLERVKNGDKLLDLGCAFGQELRQLIYDGAPSENLYGSDLRAEFLDLGYDLFLDRAISKSHFISADVLDDNSELVKQLKGQLGIVYISLFLHVFDFDQQVTVAKRVLDLMVAQPGSMVVCRVVMCRNQETLNATTARLPYYYHDLASWGRLWERVQKETGIKLNVESWEQEDALAKKHPLPGIYVLGSSIRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXC5</accession>
    <name>A0A1Q5SXC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="13">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_12618</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 13">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXC5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXC5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO92633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="421" mass="47980" checksum="E9C12AC3936B3021" modified="2017-04-12" version="1">MADLQGRKVFKVFNQDFIVNEQYNVTKELGQGAYGIVCAATNTQTGEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDQFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSIDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHYLGTPNEETLARIGSPRAQEYVRNLPFMPKIPFQRLFPNANPDALDLLDRMLAFDPSSRISVEEALEHPYLHIWHDASDEPTCPTTFDFQFEVVDDVPEMRKMILDEVIRFRATVRQQSQAHAAQQQQMAQATNVPIPENQQGGWKTEEPKPQEAAAGDGHMNDLEASLQRGMDSVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXG4</accession>
    <name>A0A1Q5SXG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein hsp9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXG4"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9530" checksum="431999549A00421C" modified="2017-04-12" version="1">MSDAGRKDFSTKAKEEITPDSSKSTQDKVKETFTDTTDRVARGFQTDDSKSTTQQAFDKSQRTHDNEAHGGATSSIGDKVKGALGMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXU8</accession>
    <name>A0A1Q5SXU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXU8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXU8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010358571" description="3-phytase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="403"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO92772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="466" mass="50547" checksum="13F42C28AC2F480D" modified="2017-04-12" version="1">MASSFKTVVTSLLLAAATGQAAVLAPANDIEFPSVKGVQNPLQYSGANTPYLAGPNVNGVVNDVPDKCTVQQAAYVVRHGSRFPDTGSYNSWVAIKDKESMTGWKEASDLGYQLRARYPDFYEDGNPFYVWANQYKSPINESRVVQTARAFVHGYLYEFADTYGTVVSVNSTGSVNAIGNSLGPSDSCPKFGATSSGGNNVTDFDATWAPKALKRINNLVSGNLTFTQSDILFFPYMCGYESQITGRLSDWCSVFTEDELRNYAYSQDLSYYYSVGPGSDGPASKLFLPFLESLLTLLSKGPGQTGTTVNGGKFNIPSLIMAFLNDNQIAEMTSAMGIFDNEDPLSTTHVKSNRLYNVGRFITMRGTVAFETLNCQVGSGKKATNETYIRILFNDAVYPVANCHKGPGKSCLLSDYLALIKEKSKAAGNWNDYCNVTAAGHPKTVAGASFFSDLSLDFLTFVKPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYZ0</accession>
    <name>A0A1Q5SYZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYZ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYZ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="178"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="514" mass="56887" checksum="25B3DFD1506A8DCB" modified="2017-04-12" version="1">MAPQNVGIKAIELYFPSRYVAQSDLENFLGASTGKYTIGLGQTNMSFCDDREATPDIYSLALTTVSSLLRKYNIPPSSIGHLEVGTESMLDKAKSCKSVLMQLFGSNTDIEGADTYNACYGGTSALLNAVNWIESSAWDGRNAIVVASDIALYKTVSARPTGGAGCVAMLIGPDAPLVLEPLRASYMQHTYDFYKPDFKSEYPIVDGHYSSRCYLQALDGCYRRYREKQVARKANGMMNGVANGHSEKAGPSSVPLDEFDYFVFHAPNCKLVSKSYARLLYNDYIANPHNKSFNPDVVPSLILEQSYEDSLSDKALEKLFIKLSKERFSKRVQQSLTAPTMCGNMYTAGVYSGLISLLSNVPSSQLLGRRVGVYSFGSGLASTLFSLRVVDDVSDIVSKVDLHARLAARERVSPKFYDEMCELREKAYQQKSYTPVGSVDALAPGTYYLVEVDEMFRRTYAVKEDSGADGMAQLTRLMQCCNWCVRWSTSSDMSLETSVIKLVGELAMRLVVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ04</accession>
    <name>A0A1Q5SZ04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ04"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ04"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="186" mass="20843" checksum="A88DC7D68C621F8F" modified="2017-04-12" version="1">MRINAAKHFSAAFQKQFVDHLRNTVGADYFIVGEYWRGHVRHLLNYLKVMEYGVSLFDVPLLGRFAVTSKTEGSDLREIFRGTLVEQNPAHAVQLGQSLETVIAPFFKPIAYALILLRAQGQPCVFYGDLYGTKEGAGAASMPSCMGKLPVLMRARKLYAYGDQRDYFEKKNCIGKQVITASDSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ47</accession>
    <name>A0A1Q5SZ47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ47"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="459" mass="50887" checksum="76E4EE8E7FE91D75" modified="2017-04-12" version="1">MASATSSEGSRAVKMTNPIGDGVDSPEQRQLIEGLPLALDLTLTTFDSNFDQSEYRERFDHPVHPLKPLPSNQPLHAPVFDDLPATGHGADPPSPIDAYAAIIEGADSSSSSKAPFTRGHRRRSTHVTRRDLEKFQKEVLGVENRASWYDEENGSSRPINPNDPQLEELNRAFALADMSMNSGAGGMAGGNNPGPGMYSNYTENSPTPNMGGMPRQPPSPAYPHSAPQVNGAGAGAGGMGAAMNASMTMNAGHQMDLHHLYEMVLELSEVLKNNREITKNIVSSAEEVMKHGNSEDASAVMRHVNGEISAARISELERALAKEKRLTEDLRREQVENTKLISDYEASVGTMVEQIRNYCQNNNMHFLYQKSHYNNLLQAERDAHLESRLDRDYWHTQTMRCAQMIRNAHQLRSTEEEVPLRIISGLQNEVRAYRNALGMAPEKPEEEYGWEILKDVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZG3</accession>
    <name>A0A1Q5SZG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZG3"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="376" mass="41484" checksum="00D4542758A7A0C6" modified="2017-04-12" version="1">MDDGASSNAEFPTVDGPSNRTRSGSASNGHRRSLSGSLLSRLSFLRMSQASAQSEAKSHTMEQDGDNEVFPPTIPQMNSEATTGARAMSAVIQQQRKTRRRRGSLRKTALLGTRLESREKRAASKSADTTTTTPRYMSEAPRSPKDVPGANGFGSRESLEYDAEDTQPSWFRASTAQKILRSPMARRRLGLTPHNLIGGEEPGTDDEELVSFPRINTTNNTSTSTGSSKLTPPTALHISTKSDYSSYPLPADPDTPYRTVHRAKSSPLATHPVEMKSTADTWDYSETEWWGWIILIVTWLVFVVGMGSCFEVWSWAWDVGETPYAPPELEDDPTLPIVGYYPALIILTAVMSWVWVVVAWVGMKYFKHANISGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZS5</accession>
    <name>A0A1Q5SZS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZS5"/>
    <dbReference type="OrthoDB" id="4506934at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="131" mass="15063" checksum="7014F7775CDE108B" modified="2017-04-12" version="1">MGASTPSEIAPPYEELYSQRGSNSHTGYARVSADDPEPDLERDAHQHQHQHQHHHQHEAANRSSLELTEARTNANGDHVHCESCDRQLERRERQRSRDQCCATVSRTMMTMSLFLMIFGIVAVLSWRRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1D2</accession>
    <name>A0A1Q5T1D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000721">
        <property type="protein sequence ID" value="OKO94069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1D2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="29650" checksum="67F03B5FACF1DC50" modified="2017-04-12" version="1">MTTNHDTDTSEDDSLVAQANEQLERELLQSQKPTLATYRAPRRVVSLGISPATSKTGRQQMLFGTCIEIDHGGLLSIVVPEPHLADQRGERENRRALGFIQYEKKTGRITIANACMQLPIDALAMGFSTKAAHKHLVGRHGEGLNLAALDLSQNHYNGYHRDWLQFEDHLDQFHRGRRIPLRVQFRVFDHLPRPSQTRILARYGSPSTTNTEETLRKQEDTILPLLVDLLRNHARSADAEMIGPLLEPSVAHQIWQYLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T265</accession>
    <name>A0A1Q5T265_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T265"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="8733" checksum="78F00F9A96F5B7E1" modified="2017-04-12" version="1">MKKYGPLGCQLLGVVFVHTPLLNGMAWLWVRENEVFADRPVTPDLAPGLGAWGWFGCVTNNALSNGVEICGASGATALGTVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T285</accession>
    <name>A0A1Q5T285_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T285"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T285"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO94370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="21650" checksum="E6E058C5DFE5FE2F" modified="2017-04-12" version="1">MFILTTISDLIQIAPEDFSKLSAVAIEDNINEKYANKVIQKIGLCVSFYDLLESSDGLIGHGTGLVNVNVKFRMIVFRPFKGEIMLGKISSSTDKGIKISVEFFNDILIPPSMLMDGATFDHADQVWTWDNDGTMFYLDVGEIVRFRVETEEWHDQIPNAPDLGEELPTDRKPAYSIFGSMQIHGLGPITWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2V5</accession>
    <name>A0A1Q5T2V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11847</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2V5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2V5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="21267" checksum="F845186E6F74A9A2" modified="2017-04-12" version="1">MSLSPRDSTYNAGPQLLRDIWGLTAVAIVILILRIVAKLRIRKFGADDILMAFALCLAVVGSIMITLAIKQGFGQELSSIKAPNVSKIIMHDYLAQTFGLAGGALGRISFIVFIIDLLVQTRSHRIILWILAGLQIVINCVFIIIIFVQCPGHTSAIWDQSGKAKCWDVHVQAYYGYFQGGKYYHVQNITDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T392</accession>
    <name>A0A1Q5T392_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthetase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000716">
        <property type="protein sequence ID" value="OKO94684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T392"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T392"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF4">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE INPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="234"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="863"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1233" mass="137259" checksum="4E971017F422CB11" modified="2017-04-12" version="1">MAIDDTKRSRIISSYASAVLDIPPDSDKWDFKLLTTWLLLLRDYYAQEIPGFIYLRPTTSSNPDWVHVSKDLRAQVLSIAIEPEASVSSTQHLVSQEVGKQQDDGSVKLNHKTCVLMLRDDEIEANGSHQEIAKIFERLKVELLLTISTSGGASIASIWNDALKQPAFSPCRVLKSFTQIFEQVSSQPNIKADEIFCATDLDIESMCSFNSKKDVKNAEIPECLHVLINTHYMEHPQKTALSSSTRDMSYLELGQKSAAVAQILVNRGVRPGETVGICLEKSIWTITILLGILRAGAAYVPMDPSYPPGRITQILARADIRHLVISDTLRKKLGDIMAESIVLSENEDLHIPHDWSKEKYKEIHDPAYIIFTSGSTGTPKGVIQHHKAVSLSLVECIEAFEINSSTRFMQFSSLAFDASILELWSPLVAGGCVCVPSEEERSSDLESTMRMLRVTDAWLTAGLVKQLQPENLPDLARLSVGGEAPSEDVITTWGNRVKLNNLYGTTEAGVWDTAKLAMEPGDNPRNIGRGIGKVSCWIADPSNAQRLRPVGAEGELLVQSPYLAHGYLKDPELSAGVFLHPSSLKWGSLVPISEGSRIYRTGDLAKFTADGDIVFLGRQGGFIKIRGLRVDLGEVEHAINSTASVYRSAIVLSKDGGSNVEMAAFVETTEKIETQLADVLHTRLSKVLPSYMIPTMFIPVEKLPMTTSKKIDRPRLRRDLSQMSQKSLERFRKGGSVATEYSTIPSTKPRAIEISCMVADLLTSRDKIYADSFRGKDFPLETVGLSSMQLVSLATLLRKRYNKKITIGSLRCHALTVCDVEDLVLKGKKETADGIEARNLIDDLTKLKPKLPFAYSRRKTVFLTSITGFLGSQILRSLLRNPEIEHIIGLVRAKTEEEARGKVEHQAKLGQWWEPSFFNRIEVWLGDLGKPQLGLNTSHMNRLWGRHGHSPVDGIVHNGARVNWIESYEELEPVNVHSTLEILSGLSEMTFPCPLIYISGGYMPTEQESLSEVAKKLSSAPGYDQTKFMSELLLEEYNKHLDKQKGNIPKARTIIPGFIVGTRQEGIAHQEDFLWRFAFSIARLQAVSKDLLGHLNVAGVDQVSNLVTDVLLQPDRYDKHTLKCFDGINVLTLCNILEDKLNIKIKKFDHSEWMEILRSDIDQADFDHPFAPVFEWLQANPLGTASQGSLFNEQETVTALERSVEYLVGIDYFLEGSHKSGPGKSVGFSRSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Z0</accession>
    <name>A0A1Q5T5Z0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Z0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Z0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="21097" checksum="A698782392D3576D" modified="2017-04-12" version="1">MAASKAIMRGPTIIKAEDDKTRQLNKNTLMAFSGEAGDTVQFAEFVQANVQLYSMRNDTELNPAAVANFVRGELARSLRSRSPYTVNLLLGGIDPTTQTPHLYWIDYLASLASVPYAAHGYAQYYCLSLLDKHHNPNIDLEQGMKLLGMCTDELKRRLPIDYKGVLVKIITKDGVKEVDFDNDKIVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T635</accession>
    <name>A0A1Q5T635_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T635"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T635"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="460" mass="49731" checksum="5DA80B8748E6ECDC" modified="2017-04-12" version="1">MDFSNSGGFPSRRSYPNLNHVSLAPLTPRFPIDDDIEPEDYFNSRHGNNDNNDGHDHLASGARTPPRTSYLSSVSVPSTPPILSHSRSSSRTRHARSKSSTRAALLSDTNLHSKQVALALHHHQASHKKQASASHPRRQFGDAASSKSDAEWMLRAGIALASSTREEKGQSWLSKRESSTSLVDMSLDDATTPHSHRHHHRTKSGASLRKSRSGTSTPGGYSRRSSRSRGGSRRGSRAGLTMTTIPPLSSASSVAAGKASSPGVGTMSPVSCGRGEGLVPDFVDESIRAEMASLQRERGFSDDESEFWDGEDDNDSEYDSFSDEAPDEFDEADLQRLTRERGFGLGSWIDRLVEWTLFGVEEWPATAPAPGSTAPAATRIGTTATSTIVTFEEAPNVTAEGENRAHDTLSLASAEDDEGDTLSHTDGESVVSVEKPGAQGGWEDASWLFRVMKRALRACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6B7</accession>
    <name>A0A1Q5T6B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetolactate synthase small subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6B7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6B7"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="95"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="322" mass="35112" checksum="1C66BBA8363EBDAB" modified="2017-04-12" version="1">MAFRRPLTLSSASVSLLSQSTAAARSRSAAASRFNAFRASSSSSTSALAYKALHRRSPLPLPVADASPQWDAPTAVSSILYETPVPPSNPPKRHVLNCLVQNEPGVLSRVSGILAARGFNIDSLVVCKTEVDDLSRMTIVLQGQDGVVEQARRQLDDLVPVWAVLDYTDSALVQRELLLAKVSILGPEFFEELLQHHREITTPAESLKEGQGHGFQEVEYHPRNLPPSQALRHKHEHLDAITRLAHQFGGKVLDISNNNCIVEVSAKPSRIDSFLKLIGPFGILESTRTGLMALPRSPLYEHTEELEKDAADVVDASTLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6S9</accession>
    <name>A0A1Q5T6S9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10953</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6S9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6S9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="430" mass="47488" checksum="239078CFED08AF6C" modified="2017-04-12" version="1">MPSVVETASPHLRMSAAKAAASSSSATTEAPPARISPPETSSVEDHFFWTYTEEPHRSRRQAIIKAHPEVTKLCGPEPLTKWVVLLVVSIQLTCAYLLRNTSILDWRFLATAYVVGATANQNLFLAIHEISHNLAFRSPLANRVLAIFANIPIGLPYSAAFRPYHLTHHKSLGVTGLDTDLPTALEAFFLNSLLGKTFFCTFQILFYAVRPMFIYSPPFTSIHLLNLIVQLSFDYALTKFTGSLQPFYYFIASSFLAGSLHPCAGHFIAEHYFFSNVKTGGTESLAQLKQKPAAKIDASHPLAELAPPETYSYYGPLNILTYNVGLHNEHHDFPAIPWTRLHKLHDIAREFYEPLPCHRSWVWVIWTFILDKDVGPWCRVKRAQGGRVVGGGGGGSGKAYNGRGGEGISAESAGPAGEEGDGWKESEIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T866</accession>
    <name>A0A1Q5T866_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleoporin SEH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T866"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T866"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO96439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="43308" checksum="0626B9D8C177D1B7" modified="2017-04-12" version="1">MGAVERPEMAGGFTDFDAGHRDLVAVTKYNYYGNRLVTASLDHRMKIWDLKDGQWQLIDTWRAHDAEIRDVAWNGPFTGQHLASIGEDMRLKIWQEDVTQAPETGRRFKSIFRLTAPHRHPFVSLDFRNIDLESWLAVITRDGYLMVLEPVSPDSLADWQTIDQFRVCAAPERGEETSFKVQFHQDPTDITHTVLPESDRKSLSLVVAAMDTVKIYRTDANRRFYHAIELNALGGLVRDISWARGSVRGYDLIASGGKDGMIHIFEVYTIAANQGSQTANSRKAERRQQQSSSTRTTSQSGIGTALANRTPSSASSRQATGDSQFRHSFKHVASLDSKHLDIWQVDFSFAGDSLMSSGDDGVVRFWKKSLSGEWLEFAETDMAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8G7</accession>
    <name>A0A1Q5T8G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8G7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8G7"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="514"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO96475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="884" mass="100041" checksum="125DF65251218131" modified="2017-04-12" version="1">MSVNDRRASYMSAPRPRVVSNRVDADRPSRGAASPQQPDNMDSLRTSTSSQKQRLPREQKNVTEKRTERTVITTREKAVQRNPIKESSSASNRGEGDKSKTKKTRTTDGMSPVGHRREADAPTAPWDPHASLIPHSTAPLSSRISIPPLASTAPQSLSPRPFRELSPDGQEAAILEDLLFVFMGFEGQYIHYHSTYDPSVEKDRLTGPVFQLAAGLDPTLRDLTQSMLKMATHYSAMEAFVEVQSRAEFGAVCHALCASIRKILKDYLILIAQLEAQLLNNPSFTLHQLHLHTMPTSQCFTQLYSIGQELLRRNGLLDSEELDETIDDFDDVDNILEQLKEGGDLVPGSSRKVCKGGNVLRLLTERLATFSGDPTTKTLIQTLLRDASRPYMNMLNEWLHHGGIRDPHAEFLVKEQKWIKREKLEEDYTDEYWEKRYTIRDDEVPPQLEGVKDRVLLAGKYLNVVRECGGVDVSKAVKDVPKTLDDPRFLENVNAAYTYANASLLNLLLTKNSLTTRFRSLKHYFFLDRSDFFSYFLELGASELRKNVHVVNEGKLQSLLDLVLRQPGSIAAQDPFKEDVKVRMNKVGLTKWLMQVVSVSGIDQDHPEAAFEKQQAPSSQNTDDDNSITGFSGLELDYSVPFPLSLVISRKTVLRYQLIFRHLLSLRHVETLLVTSWADQNKVASWRHKPSDRRLELWKRRAWNLRAKMLIFVQHLLYFCTAEVIEPNWVALMDRVNGADANGSEVTVNGSKQVNRTVDELMQDHVDFLDTCLKECMLTQAKLLKIHSKLMTCCTMFGQWTASSLSRALSSADPDLAGDKAGGPDARPYDPSRIVKLEETLKRYEDHFNRHLRILMDSLNYFAATESVVLLKLAHSLSSISKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8I1</accession>
    <name>A0A1Q5T8I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-coenzyme A thioesterase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8I1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8I1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="33"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="159"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="347" mass="38785" checksum="AAD617D4F8409AF6" modified="2017-04-12" version="1">MTNMKPSPIESHIQVAPFSESHPDVFKNQQKLWRPGSRGIFGGIAIAQSLRSAQLTASNGFDVHSMHCSFLSAGNAEDLIEYRVERVRDGRSYCTRFVRAIQGNRPIFLATISFTLRQSRDMSRGMAHSASLPAVMLDEDEVADLGQSCKISSATPYINKSAGVLRGTSRNPQDKRSHQWIRAQGKISVPPGDPIHLAALAFMSDSYFLAAVPHSHEIWDFVEAPVTEFYSTKKDLFTSPMTHTAIRRPHLETEHKKGVNVSPKVAMMVSLDHTIYFHGVERLRVDEWLLCEVNTSWAGNGRGLVHQKIWTKDGVLVATCIQEVSFLSFLHEWIAMLTVPGNRETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8J1</accession>
    <name>A0A1Q5T8J1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8J1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8J1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14043" checksum="7AB2D2216EC4AEBB" modified="2017-04-12" version="1">MFDEVFTDEIAAILQHKDITTSVYCTKLDVTPQESESDDCALSKKSVPGVTSTGVSSPASNGGLRFMAGRPNIHELVMNEVHEARTSSSSIGVLTCGPSQMADQCRGALYEAMKKGFHEIDYFEEAFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8R8</accession>
    <name>A0A1Q5T8R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8R8"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="233" mass="26895" checksum="F22B573D71A89ACE" modified="2017-04-12" version="1">MPDLHSLPEGTWPEQAIRNNGPDNLVLERAKLRELAEGWPCYRDACEWENFESIFHEDAYVYTTWSGRVSYKDFMAASKAGMDKGAFIMHRCHGVTTDITPDATRAVTKMKATITQRFTIDGCEVDAEADCRFCFFFEKANGRWGARFVRHWYEKDKLLPVNPNKIPRINDEKLNSYPEGYKCLAYCQELTMGVTVLRDMPGHRRHVGTVCGEKHDLLYRLSKDWLDGKTIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9Q0</accession>
    <name>A0A1Q5T9Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9Q0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="36484" checksum="849E6338C30E2CA0" modified="2017-04-12" version="1">MLFRDTVRYAIHFTAQYPREKADSAYVGCIARQTENLLRWITQHITANRQATPSSTATATATAMGSEPQIRPALPMNGPPKNAPQHAAPPVIMPALQMETKTKHIRDPHSSLQVPGYETESSQDNENEKSGEDETSDREGLGVERNGGETFGTEQEEEIRQGAGEVLPDVGFLGGRAGPRADDKDTEESSERDLPGSEDYDSESSATESDEDAQKHADEALPDVRLIGGSNDDKVDDGDPEESCQSDLPGKHSETSDATHDCQGNTEPVTEERGEQEMGDAQQADDDDDGSSMDTASDISDRPQGIRSWIPNHVEEALSEGTSAQSVEPVEHWPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAH6</accession>
    <name>A0A1Q5TAH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10017</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAH6"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="394"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="226"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="87"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO97223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="54326" checksum="09D1D573AA7C28A1" modified="2017-04-12" version="1">MFRTVLPRATPRAALRAAGPKAIPSTFITPPMVFIGRSKRGYASDAAEHDLVIIGGGVAGYVAAIKAGQEGLKTACIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDTKKRGIEVGDVKLNLAQMLKAKDQSVDGLTKGVEFLLKKNGVDYIKGAGSFVDANTVKVDLLDGGEQTIRGKNIVIATGSEATPFPGLNIDEKRIITSTGALALQEVPKKMVVIGGGIIGLEMASVWSRLGAEVTVVEFLGQIGGPGMDAEIAKQAQKILAKQGIKFKTGTKVVKGDDSGALVSLSVEAAKGGKEETLDADVVLVAIGRRPYTEGLGLENVGIDKDDRGRLVIDQEYRTKVPHIRVVGDVTFGPMLAHKAEEEAVAVIEYIKKGHGHVNYAAIPSVMYTHPEVAWVGQNEAEIKASGVKYNVGTFPFSANSRAKTNLDTEGVVKFIADAETDRILGVHIIGPGAGEMIAEATLAIEYGASSEDVARTCHAHPTLSEAFKEAAMATYSKPIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAR7</accession>
    <name>A0A1Q5TAR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_10072</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAR7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013022099" description="alpha-amylase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="30"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="47"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO97278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="519" mass="56256" checksum="8D1FC1A46EB1B7E2" modified="2017-04-12" version="1">MWWLKLLVLAVVGTVEAASRDQWISRSVYQVVTDRFARSDNSTTASCEAGKGDYCGGSFQGIIHKLDYIQELGFDAVWISPVQSQESTRTADLSDIVVGDMAWAGNASTIDYSTFNPFSDQKYFHDYKLLSEDPSNDTCVLDCWLGDKTISLPDLRNEDHEVQQILGSWVSQLVSNYSIDGLRIDSVLNIDPGFFSNFSKSAGVFTMGEGATRDASGYCELQPSLSGLLNYPLYYILSEAFNTTKGDLNRIVQSINYIRTQCDDVLPLGTFTSNQDVPRFGSYTSDISLARNILTISMLADGIPILYYGEEQHLSGGFNPINREALWLTKYSMNSTSLPLLVQTLNLIRSYASGDGEKYTVSPKSGSDYLSYLSLPIYNSTNILAMRKGFTGNQVVSVVSNLGAKPAAKATTKITLGADGTGFSSGQNVTELLSCRTFVTDSSGNLNVDLSSDGGPRVYYPTESLNLSTIVCGDHTKTPTTTSASPKPSTGAGNSLLGLSWGISTLTVMAALTASYISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB91</accession>
    <name>A0A1Q5TB91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-aminocyclopropane-1-carboxylate synthase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB91"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="80"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="435" mass="48496" checksum="8352DF0B52C121FC" modified="2017-04-12" version="1">MAQQTGSTLSLRAQDASAAAAQNLMWDILVDTWCPSSNPNGYINVGVAENALMHTELLEYLNKNPEIPAEYLTYNDGGGGSNRLRRAIAQFLNRHLKPVTPLDAEQLVVTNGVSPAIEHVSWAFADPGEGILLGRPFYGTFIPDLSTRPGATVVPVNFDDVDPFSAEAVSKYEDALLFFQESTGKRVKALMLCHPHNPLGRCYPREVIIKLMQLCQKYQIHLISDEIYALSVFENTVDEYPPPAKFESALSIDLNNIIDPKLVHVLWGMSKDFGANGIRLGVIISQFSAEFHGALRAISLYSYSSGIADHMVAGLLEDDAFTESYIKENQKRLSESYAFAVEFLKKNGIEHATGCNAAFFLWVDLGKRYRELHPEILAEEEVGEKIMQRLLQEKVFLASGALFGSEKDGWFRIVFTQPRDYLELALKKIVKAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBE2</accession>
    <name>A0A1Q5TBE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF924-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12461" checksum="53BF748FFF209A1D" modified="2017-04-12" version="1">MAPKTYKDVLDFWFGAKSSRDYLRPKPFWYGSPADDKYVRKHLSECYEAARDGTLDHWRVRGKGEGALTLILLLDQVPRNIFRDTPEAYATDSKAVSVSRYAIERDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCC7</accession>
    <name>A0A1Q5TCC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9802</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCC7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCC7"/>
    <dbReference type="OrthoDB" id="2130367at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012908676" description="rhamnogalacturonan endolyase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="13">
        <location>
            <begin position="355"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="445"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO97876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="661" mass="73244" checksum="3805C36B251CB2F4" modified="2017-04-12" version="1">MAAFLTFLVTGVSLVSAALQVSQNDTTITVANDRLTAVLRRSAGQIVDLSLDGQDLLGPQSGSTGIGPYLDCYCIPSGFYTAGATTPSTEVVQGVDSTGTKYAGVILTDTYTPTGQQFQQYWFLRDGETGLHMFSRLSYHNETTPFLRNLQELRTLFRPNTALWTHLTSSEVQTAPLPSKNAVSHEVVVQDATWTFNNTPTDAYYTQFSDYFTKYTFSNPWRNNSVHGLYADGSNSSGTTYGAWLVMNTKDTYYGGPIHSDLTVDGIVYNYLVSNHHGEGTPNITNGFDRTFGPQFYLFNGGKGSKSSLNELRAEALELANPSWNAAFYDSIAKHVVGYVPSGQRGRVRGTVKLPRGAIRPIAILTANGVYHQDNSAVPDAYQYWVDIESDGSFTLDRVKEGEYRLTIYAEGIFGDYVRDGIVVRGGKSTTVRDSWEEESAGTEVWRLGIPDKSSGEFRHGHAKDTTHPLQPPEYLIYWGAYDWTKDFPDGINYTIGKSDPAVDLNTVHWSVFGPTPSNAHVEYNTTHDWNIHFKLDAKQLRQRKTATLTVQLAGAKTAAGNTDVWNPKETYNNLSLESYINEHSNPLTLVIGFNQSSSCIVRSAVSCYQVSSRMSFPASWLHEGDNLLRLHLPYNATDTETAILPGTVYVQYDALRLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCR7</accession>
    <name>A0A1Q5TCR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCR7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="60"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="555" mass="60341" checksum="6A849A737F25BC53" modified="2017-04-12" version="1">MASEKVAPAPAPEITSKSVKGETLDSDNKHVAQDIKPSDAEGNHSKSAPGELKRKLKSRHLQMIAIGGTIGTGLFISSGTAIAYSGPAGALIAYIFVGSIVYSVMSSLGEVATYIPIPGAFTSYAARLIDPSLGFSMGWIYWFNWASTFAVELTATGTIIQYWDPSLNIAIFIGVFWVFITALNFLPVNFYGELEFWFSTIKVATVIGFMIFAICIDCGVGAQGYLGFSYWKSPGAFATHLIEEPPSVGKFVGFWAVLIQAGFSYQGTELVGVAAGETENPQKTVPSAIRKTFVRILLFFVLTIFFIGLVVPYTNDRLTTSTTNASSSPMVIAADLAGVKVLPSLINVVLLTVVLSAANSNVYSGSRILTGLAHEGFAPKFFARTTKGGVPYISVMFTALFGLLGFMNVSADAGQVFTWLVNLSSVAGFVTWSSINACHIAFMRALAARGVSRDTLPYKAVFQPYLAWYGLFFNILIALTQGFTAFIPTFNVTDFFIAYICIIVFVVLYLGHKIIMRPSFVKAAEADLDTGRLDYKKETGPPKPWYWRVWGWVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDD5</accession>
    <name>A0A1Q5TDD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ERF1 methyltransferase catalytic subunit MTQ2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDD5"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000274">
        <property type="entry name" value="ERF1 methyltransferase catalytic subunit MTQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="29763" checksum="B765520C0B7884D7" modified="2017-04-12" version="1">MLPTPDTSHVSFDTIYEPAEDSYLFLDTLSSASESKWLSERFKKSTRTSSDSSNAVPLVVEAGTGSGVVLAFAAAQSQHIFGRQDILTLGIDVNRNACIATRETVSAAIKTVQKDTETSAVDQILNTIHISSITSDLCTALRPGSVDVLLFNPPYVPTEELPRLPTESENDPTKSQAMPRSAKFESDSYFLSLTYAGGADGMETTNRLLEAIPGVLSDRGVAYVLLCKQNRPDEVKERIRAWGGWNAESVGSSGMQAGWEKLVIVRIWKQEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE95</accession>
    <name>A0A1Q5TE95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE95"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="19418" checksum="8212504A515BD681" modified="2017-04-12" version="1">MRFHGRNLLGRVQEIVIISLEPEPEPGLLVPQPQTPYLLEVLSTHGATSDQQASNQRLVAGHCDTKTTKKKAADQQVALVQSSREYLVTTFLALVLARARIPSEIDQPDLDKGLIWAKLKRNRSGGHHQQSKSEDGQTKKKNWETKSQEVGQNVAERLLVVEELNSHAPKFWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEC2</accession>
    <name>A0A1Q5TEC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 SUMO-protein ligase pli1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEC2"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16792">
        <property type="entry name" value="SP-RING_Siz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031141">
        <property type="entry name" value="SIZ1/2_SP-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF100">
        <property type="entry name" value="LIGASE SIZA, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G05240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="12">
        <location>
            <begin position="111"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="291"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="517" mass="56241" checksum="70E75F6B83D19961" modified="2017-04-12" version="1">MASSGQLSEIPHLVALIKTLTNANLKDLLRNEGLAVSGVKASLQLRIIDYLERLANSEGNGARYDALRRRIYQTAIPGASAFQSSSPSYQLPPPPTAQATPSQPRPASLGGTMAPHASSHSHLAFKESPFFTILNPLTKVMECKVREQTRDSVELKVTLSVSTATDLTTDPNLRVMVYCAADSGLKQYTKSDITFPHQVELKANLDEVKANLRGLKNKPGTTQPADVTPHIRKKANYPNTIVMTYALTTKKFFVIANLVRQHPVDELVAQLKSRKIISKEQVIREMKNRAEDTDIVATSSIMSLKCPLSTLRIQVPCRSVVCTHNQCFDASSFLELQKQAPTWTCPVCSKSTSFESLQVDQYVDDILGSTSTEVDSVVVEPDGTWSAPSDADAVNLGGRTPASDDDDDDLIEIREPGTSAVKQEPMSANIMLERTPAQSKSREASTPSSAARLSSKKRPAAQVIDLTGSDDDDDESPVPPVKRPALNLGIRGIATHDPYQPGANSPLNNRAYPPPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF40</accession>
    <name>A0A1Q5TF40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="2 9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_8770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2 9"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF40"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000049">
        <property type="entry name" value="RNA Polymerase II CTD phosphatase Fcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="12">
        <location>
            <begin position="155"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="511"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="676"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="830" mass="92645" checksum="37DBA1CEBDCF5990" modified="2017-04-12" version="1">MQLRLPPSLHYPITVTSLLKREGDTVERDEAIFWYIYQTTVEEGDGLGNQVMVKRKFPTRFESTVDGTVVKWNIAKGDVIDEPVDVVEVEEPCAHEVQFGGMCAECGKDMTESTYNTEISETFRAPIQMTHDNTTLTVSEKEATRVEEDAKRRLLASRRLSLVVDLDQTIIHATVDPTVGEWKDDKDNPNYDALKDVRSFQLVDDTPGARGCWYYIKLRPGLEGFLEKVAELFELHIYTMGTRAYAQNIADLIDPTRKLFGDRILSRDESGSLTAKNLQRLFPVDTKMVVIIDDRGDVWRWIPNLIKVVPYDFFVGIGDINSSFLPKKQEIVVTPKSSRGSKEKGKEKEDQEHHVNGATMKTGPETEVSALEQLVTMGGGDDPRLLQEQADAQEETIMHQVEDRPLLQKQKELDADDDASADGSESSSSGDESQEVARPRHHLLVDHDTELFQLQDRLEAVHKIFFEEYDKKRTHALGGRVAALRGEKAASKDKDVDLKLVPDIKDIMPLYKAQVLGGVVIVFSGVIPLGQDLQNAEVSLWAKTFGVVVLKNIGKRVTHLVAGRNRTAKVREATRWPNIKIVTTQWLYDSLINWRHMDEDPYLLPVHPDDRGEPLSPGSRELVDNSWMSSSDEATNVTDDDASDELFKDAGLSESSPLSYDEEDQAAVHDELKDFLGSDDESESDSEFFAEEGAEPSRKRKRGEGSDGNADEESTHEDGDEVDAKGSRLSQRIKRSYERSTGLRDVATPGGSETEETRFEKGQFPAPDDDDEGEAGVATVVGDKQETQSETAVEGSDVDADDFEREMMAAFDDPDYSKESGAAPTSTDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFC0</accession>
    <name>A0A1Q5TFC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFC0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="254" mass="27759" checksum="DC3483D403D83D4C" modified="2017-04-12" version="1">MSGSAGYDRHITIFSDQGRLYQVEYAFKAITSANITSIGVRGKDCAIVVSQKKVADKLIDPSSVSHVFKISPSVGCVMTGSIADARASVDRARGEAAEFRYKFGYEMPCDVLAKRLANINQVYTQRAYMRPLGVAVTLISVDDENGPQLYKCDPAGYFVGYKATSSGPKQQEAQNYLEKKLKNKDAAPGSWEEVVELGITALSNVLSVDFKKHELEVGIVGGPRTDGKEGTTTEFRALTEEEIDERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFK2</accession>
    <name>A0A1Q5TFK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-fucosidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFK2"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000028">
        <property type="entry name" value="Alpha-L-fucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF18">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 95 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="263"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="664"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="745" mass="83409" checksum="37FC91489A1F61A4" modified="2017-04-12" version="1">MSKLWYTQPASNWNEALPVGNGRLGAMVYGRTDQELLALSEDSVWYGGSQDRTPQDALKYLPQLRAAIRAENHKEAERLAKVAFFANPISQRHYEPLGTVFMDFGHESDRVTNYHRELDLETSTVSVSYNHCGAEHRRQVIASYPDDVLAIRVLAPANTEYVVRLTRLSELEFETNEYLDDVAASNHSITMHVTPGGRNSNSACCILHVQCSQEGTVTRIGNNLVVKASESLIRITSQTTFRHQDPDQTASEDLAKSLGYDARQLWDRHVKDYQSLYNRMRLQLSSDVPNIPTNKRLLTSRDPELIATYHNYNRYLMISSSRTGHKALPSNLQGIWNPSFHPAWGSKFTINVNLQMNYWPANVCNLSECEMPLFDLLERMAESGKKTAKVMYGCRGWAAHSCTDIWADTDPVDQWMPATIWPLGGAWLCYHIWEHFQFTQDLAFLSRMFPILRGCVEFLLDFLIEDATGKYLITNPSVSPENSFFDLKGQKGVLCEGSTVDIQIVRAILSAFESCADQIGESGSLLSAARAARARLPPMTISDSGYLQEWAVDYGEVEPGHRHTSHLWALYPGDAIVPAKEPELAQACRAVLRRRAENGGGHTGWSRAWLINLHARLLEAEECSRHLDLLLSHSTLPNLLDSHPPFQIDGNFGGGAGIIEMLVQSHEPGLIRLLPACPKDWKGSIRGVRARGGVELAFSWDRLSLLSLTVMLPNPGGKVSICFPERDETKVQEVEGPGVHVIIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG27</accession>
    <name>A0A1Q5TG27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="52" mass="5861" checksum="81FF2868A92CDAD6" modified="2017-04-12" version="1">MDTVIKVGLTPKNDPEVFQDYHIWYTTEHIHRLKKVEVGSQGVATDCSSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK55</accession>
    <name>A0A1Q5TK55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK55"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="87" mass="9495" checksum="2FA99A2436475AD1" modified="2017-04-12" version="1">MTQELMKPDGNRMKRVAEDEDTGESSRAVCLPLRDVTNTLGIEKGTEINKSDEKKRQRTMDVAGSGDDDHGVGKRSKTVVDGTSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL63</accession>
    <name>A0A1Q5TL63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopenicillin N epimerase component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL63"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="380" mass="41356" checksum="E996CAE3FEC104FB" modified="2017-04-12" version="1">MAAPPPLNGIRVVELAGLAPGPFAGLLLADYGASVLRIDRPSAVSGDQLTRRKTSITLDLRETKSREILLRILTATDVLIDPFRPGVLERLGLSPTEVLLKHNPRLIVARMTGFRRDGKYKDMAGHDINYIAVSGVLSMLGRAGDKPYAPGNILGDFAGGGAICFLGIILALIARTSTGRGQVVEANMVDGSAYLATFPRLATKNPSWGEPRGENLLDSGCPYYDTYETKDAGKYFAVGALEPQFYAALLRGLELDPKKMPAREDRDNWPALRNIFTRRFKEKTRAEWEAVFDGTDACATPVLEHCELESAGYEQRPAVHLSRTPGYPIKADEGGWTGGGLEPGEGGVETLRSWMGWEPNKDFQVRKDGALVSVDGRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLD5</accession>
    <name>A0A1Q5TLD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLD5"/>
    <dbReference type="OrthoDB" id="4498167at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="125" mass="13277" checksum="045E5C9B359ADE57" modified="2017-04-12" version="1">MTEGHQMQQPSDNIHNMFAHESGETGPSHGNHVETQRSTDPRNSLEDYNRTMLEYTQRQMSSFVDIDDNNSGNSGSSRSSQSSGNSGRSGTSSNGVLARQANGAPPTSASAAAAATRHAAHQHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM47</accession>
    <name>A0A1Q5TM47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7297</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM47"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP01307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="38032" checksum="C0A12342B0B43383" modified="2017-04-12" version="1">MNATYVSAFLAAGHYATDTLVIGGVKVKDMEFAVAEESQNPHGILGIGYAINTDAATSQGHNYANLPEALVNSGAIKSPAYSLWLNKFDGTGNLLFGGVNKARYQGELQTVPVLPLYGKYYSLAIALTDISVKTSSGTKDFATGLPIAVTLDNGSAFIALPQEIIDPILKEVGAGYSKSDDVAYIDCTKPTPDYNVTFSFSGAKVNVPLSELVLDGYAQPGFPKGNCILGLTYSQPGVNLMGDSFMRSAYIVYDLANNEISLANTNYDGGDDDILEIGTGSDAVPGATLMRDPVTSATGNGAVATGGAAAAPGTTIYVTGTGTATGTATGTATGTAKGGAAATSTSKGWAAVQTSNPGHLLPGLLGAGLLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TME2</accession>
    <name>A0A1Q5TME2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">PENSUB_7390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TME2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TME2"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="147"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP01400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="779" mass="87370" checksum="54BE7D695818ACA6" modified="2017-04-12" version="1">MDARKASKKRKAVTRDVEGEAGVFSGDELSGENLDGALSDNNNDLSESEEEDSDSEIELIDDFSDEDDEDEEEELDSDEIPSDTEPVATKKTLKSTPTDNEPNFRIVKDANGNERYLYDEINPDDNSDYSDVEENANTIGDIPLTFYDQYPHIGYDINGKRIMRPAKGEALDALLDSIEIPKGWTGLTDPSTGKPLELSQEELELLKKVQMNESTIDGYNPYEPLVESFSSQLEIMPLSAAPEPKRRFVPSKHEAKRVMKIVKAIREGRILPYRPPEEREEKDEDIINYDLWADEAERPDHIMHIPAPKLPPPGYEESYHPPPEYLPDKKERKEWEQTDPEDREKEFLPNDFGSLRRVPGYENFVQEKFERCLDLYLAPRVRRSKLNIDPESLLPKLPSPEELKPFPTTCATVFRGHKGRVRSLNVDPTGIWLATGGDDGTVRVWEILTGRQLWSVKLSDEDAVNVVRWRPGKDAIILAAAAGDDLFLAVPPMIADPEMEKASLDIIDAGWGYAASNPPPSAAEANKKNTPPQWIRPSSELADAGVCVVIPLRYIPKSISWHRRGDYFVTVCSGASTPASVAIAIHTVSKHLTQYPFRRRLKGGGPPQTAHFHPSKPILFVANQRSIRGYDLSRQLLVKIVQPGARWISSFDIHPTSSTASGGDNIIVGSYDRRLLWHDLDLSQRPYKTLRYHRKAIRAVKFHPGGRYPLFADASDDGSLQIFHGSVTGDMLSNASIVPLKVLKGHKITGELGVLDIDWHPKEAWCVSAGADGTCRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP24</accession>
    <name>A0A1Q5TP24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP24"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP24"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="152" mass="16935" checksum="D6518B689B29B3FF" modified="2017-04-12" version="1">MAGLVAKSTTDHFVSDLTMKNVVAEIAIYRALKAELPAITGITAEETFKMVGVNQRRSSDDEISITWSQVSAVSKEFQRRHLDESILKDATDQWDDIAMAVEQILAGDSKISEDQIKHRLGDQKHDGVDLLNPAPPGEDGYLDKWRQDIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ92</accession>
    <name>A0A1Q5TQ92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ92"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ92"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="4">
        <location>
            <begin position="469"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="796"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="917"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP02408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1122" mass="126499" checksum="FD25293837197F22" modified="2017-04-12" version="1">MPHATQNQAQEAPEDAEFDNVMRQLNNYEGGPQFDFMNRDLDVGEKADDAVDYEDFEDDELPEEEEPEALRRPAENDAHDDLFADMGGDDAGLFGPSDDIFGGTGEGEQTQDDNLDDLFGEGPFSPPLAGQVDDTRDLFEDEEPALSTQPVELPPIPPVKETSDQPMVEDVDEDDILDDASVLSEEMDEATLRAWKLQQQLFAMSGRTGPDHLPAPPENHEELLHSLFPSFDRNTLPRWLEIIPHKKAYYLGKQPLKVPKPVLPTKVNIELAPDQERVFRTGQSNKRGLDQEALGIVVITEAAQEEAEEDEDNEDFDMGEADADEILPGGFTMQDLRTICVDWEVKDEISSTTEETPAILNATAPHDSTDLFDDEVDWLMEENPPVKKRKTGPTPIDVIALSHLDIPLLDEPEQAVSQIAKRVTIDMNDPNILVEELRPDAVLPKPKQTGPRNREDVDTNLTRKLTSRYNISNDQAYDMLKQNHQNKIRSTLGNVTLEHAMPALRLQWPYYKTELQKAEARSFHRPALNFRTGQTSWFKNPAHVKRKHLKGKDAKSLFDSTKSLSLADNSSVLLVEYSEEVPMVLSNFGMCNRFINYYRRKNPEDPTRPKAEIGETAVLLPQDKSPFSIFGHVDPGEIVPAISNSMYRAPLFPHTAKSTDFLVIRSTTGSMGMSYYIRNIENFYIAGQQFPSVDIPGPHSRKVTTVAKNRMKMLVYRLLKKSSDERLAISDVTAHIPGTTDMQNRQKVKDFLQHDKDTKYWKPLDPVLPDQDTIRSWVQPEDVCLLESMQVGQQHLHDTGFGNDAENGNENDEDEEGESFEQLMAPWKASRNFLLASQGKAMLKLHGEGDPTGRGEGFSFIKTSMKGGFKAIGESVEDKLDAQRLKELGGHSYNVARQQKSYETSIRRIWDAQKASLSSTIEHSDDESDVDQGEIEEFNKPTPRSEAPTPAPTRRYDDETTSQFSRMSFTSQKGKVLRITRQFKAPNGEILEKEQLVWDPRVIRQYIQHRHRSEALTTKLESLQPTGDPEVDARNRKLIEAELSRLNRNKERRFAREKQKGISRAGESPADGKPAGTQRKCANCGQVGHIKTNKKLCPLLNGTMKPEDRVTDSAFSMSAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXN7</accession>
    <name>A0A1Q5TXN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP04996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15705" checksum="BD28512BC3DF423D" modified="2017-04-12" version="1">MLNHIIKGQYIALHNTALLEQVNANLRSAKEKIVKKRTRSTKLIPCEEFLTGGEIDEANPWLRQTQWAEYLLGINRGLLCDCIAAPTEEANGLEAVARRIWVAMGEVAQISQQITKATGNAIRSEAVRTEKDRSPVQPLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B6</accession>
    <name>A0A1Q5U0B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B6"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP05915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="37674" checksum="D34CE1D63B93263E" modified="2017-04-12" version="1">MVASELSQAPDGLIGGYKGGSLPVRILMIVFSSIALYNAIELFILLFLTFQHYRGLYFWTLLLSVVLGVIPHTIGYILEFFSLAPLWLCLTISTIGFYVMVPGQSVVLYSRLHLVVQSHRILRFVLWLIIIDSVLLLVPTTVLTFATAYVGTIPIIRGYNVMERLQLAWFCAQEFVISGIYIFETVKLLRLMPDKDHRRTKIMYELLAINFVIIMLDVALLVVEYIGYYSLQTTLKPMVYSIKLKLEFGVLGKLVSLVQTHRSQPTSSEHEEYPNFVDPTQFTTDVTHAAPVESRRSRIGAWNAISMESLPSSEQRIRPSTRSRLSSDGGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1N3</accession>
    <name>A0A1Q5U1N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_6382</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1N3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1N3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP06392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="794" mass="90811" checksum="1A39C2233772E5B7" modified="2017-04-12" version="1">MKFFIDDLPVLFPYPRVYPEQYAYMCDLKKTLDAGGHCVLEMPSGTGKTISLLSLIVAYQQHYPEHRKLIYCSRTMSEIEKALAELKGLMKYRSQELGFEEEFRALGLTSRKNLCLHPSVKREKSGTVVDARCRSLTAGFVKEKKERGEEVDLCIYHENLDLLEPHNLVPPGVFTLDGLSRYGEEHKQCPYFSARRMMPWCNIIIYSYHYLLDPKIAERVSRELSKDCIVVFDEAHNIDNVCIESLSIDLSEDSLRKATRGATNLERKIEEMKSTDAEKLQNEYSKLVEGLQQAEQAREEDQFISNPVLPDDLLKEAVPGNIRRAEHFVSFLKRFIEYLKTRMKVTHTISETPPSFLTHLKDLTYIERKPLRFCAERLTSLVRTLELVNIEDYQPLQEVATFATLVATYDKGFVLILEPFESEAATVPNPILHFTCLDAAIAIKPVFDRFSSVIITSGTLSPLEMYPKMLGFTTVLQESYSMTLARRSFLPMIVTRGSDQAQVSSSFGIRNDPGVVRNYGTLVTEFARITPDGVVVFFPSYLYMESIISMWQGMGILDQIWNYKLILVETPDAQESSLALETYRTACCNGRGAILFCVARGKVSEGIDFDHHYGRAVLCIGVPFQYTESRILKARLEFLRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFERKRPQLPKWINQAMLDSETNLSTDMAVANAKNFLRTMAQPFKSRDQEGISTWSLADIERHEAKRKAEEARLMNQEAAPAHQMNGAPSTIQIVEDEYDDDIDEDLMMLDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1R5</accession>
    <name>A0A1Q5U1R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1R5"/>
    <dbReference type="OrthoDB" id="4353051at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012479796" evidence="2">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="160" mass="16907" checksum="2B6DBEFFE8D4ABAB" modified="2017-04-12" version="1">MHFSKTLASAALLVLPACAAFPVASVEFQSWETCPVGAPALGEPKFKAAVTATPVTCDKATVNRDWSIDNYAFKAYLDTKDALLCSGVTIWNNDDCSGEPVSFLPFDGEPVVQGQCLPDILDPGYVSFRLECFGFPGGPGFTNGPQVSDGGEESDGPEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1W7</accession>
    <name>A0A1Q5U1W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin-related protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1W7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1W7"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="388" mass="43503" checksum="1953362724DB9753" modified="2017-04-12" version="1">MADVPIVLDGGTGFLKVGYAGQNFPEHQFPSIVGRPILRTEEQAGDIVVKDIMCGEEAAAARSMLQISYPMENGIVKKWDDMQHLWNYTFYDKLKIDPTGRKILLTEPPMNPLKNREQMAEVMLEGYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIIPVYESTVLNHHIKRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKKLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVDQPGMAELLFNTIQGTDVDIRSSLYKAVVLSGGSSMYPGLPSRLEKELKQLWLTRVLGGNPERLNKFKVRIEDPPRRRHMVFLGGAVLANLIADKDDMWVSKQEWEEQGARALAKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Z6</accession>
    <name>A0A1Q5U7Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7Z6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7Z6"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP08584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="28830" checksum="945C7A072D824E37" modified="2017-04-12" version="1">MDHFPGTWGRPRNDVYGAYDPSYLQSTGPKTHTTSPAVTGTSVIGVKFNGGVVLATDNLASYGSLARFTDTKRLRIFGNKAVVGFGGDVSDMQYIDRLLESIDIRENYSSHGNMLNAKNLHTYLAKVFYKRRSEFNPLWNHVLVAGFDGEGKPFLSSADLLGTTFSAPHLATGFGAHLAVPILRRLFPEEKPIEEISREEAVDALKQCLKVLFYRDARSLDKYSIAVITQEGIDLKEDEQLEGQSWAFAERIKGYGAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA73</accession>
    <name>A0A1Q5UA73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5283</name>
        <name evidence="2" type="ORF">PENSUB_5285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000527">
        <property type="protein sequence ID" value="OKP09368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000526">
        <property type="protein sequence ID" value="OKP09370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="61387" checksum="6C0F4B7F288E8E90" modified="2017-04-12" version="1">MPNKGKKKAQKAKKSARDIQTPVSDRENSVDSGKAISSEREDLQTTKGKRGDLRVRYARSPTREGDFASNAGDHDSDNVTDHDSDNVTDLELNDASDGDRPIEEEPNPLSAWVKDVIYSETSKQSERMVEEFFTAKEPAYDECKAFFDRLNQLIRGTNEQNGVTDVETGAINPTYYNKLCQTWQQSANKAVEDQSPEEFWSAFNQTRDLIKIFNKRHHLPKAWNISQEWAEQMIGTQNPRTGDTESTATSDDGQSTLTDQQAMNERLGVSSDIESDDDNQTGLDALESRTMKQQRRLTSAKVLYWWPKGTGSQIFVRYGDRNTPIYRIRAGSHESYSPHIVERVLTQTRGNAKISGTKNGLPEEFWKYKRKDVENILGVGWKIEDDDEEGFNPLDLLRPAKGASYPHTRALVKWKDGVTTLEGRSFIRRISTGSSLDGDRMIYQKAEELETAYRERHGLEDIVDDDYDEEDSDIEVSHGRRYRSEPARYSKSAKGKSRGHYRHDSSEYSDSESDAVAQSHNSRYRRHRIVACAMLLPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAS3</accession>
    <name>A0A1Q5UAS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein brlA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000492">
        <property type="protein sequence ID" value="OKP09561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAS3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAS3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="179" mass="20704" checksum="44F6F8C383D84626" modified="2017-04-12" version="1">MDWFKDGSVLESEVEVFTRNPTIEPYSVIKPNMSDKPPDGGWRTTSWQDFEEFTRLVCGNQGHSSHTLNSIPWQLPRRQFKCSVAKCSSRFRYFKGLQRHLSGHLAEKSYVCWVPECQRSFSRRDNLKAHYATHGRQGGRNRYVATLDRTSPAYDPCFRGQLTSDGWPVREVNMGLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBM5</accession>
    <name>A0A1Q5UBM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBM5"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000095">
        <property type="entry name" value="Cyclin Ccl1, putative (AFU_orthologue AFUA_5G07030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="80"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="417" mass="46631" checksum="E0D5A88B665F18C3" modified="2017-04-12" version="1">MIEDDIYRTSSQFRLWSYTESSLKNLRTTTNNIASERVRAALRRARERHLSATPSATGTPQPGSDAEEKHIECLTPEEELVLVRYYCEKTVELGDTYRPPLPTNVRATAIQYLRRFYLTNSPMTYHPKSIMACALFVATKTDNYYMSLRSFAEGIPGDTTPDDVIAPEFLLMQGLRFTFDVRHPFRGLEGGVMELSAIAQGQGKPAPHLPQHTPESLKEGILNLAPPPVPVSSITDRIGRAHGATRELLKSAAQMTDAYFLYTPSQIWLAAFLIADRPLAEFYLDTKLGGPIDPTAMETDTSTLHNPLSELRTKLLKVLGDCAALLQSYTPLSSDPDQMKSLKRIAKKLYHCQNPEKVNLKRDTTAPRLMPAGDAGTVTSESETERLAKKRKLEMESKQRGGHDVFGPELVPDRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBN9</accession>
    <name>A0A1Q5UBN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBN9"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001035">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000868">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="63968" checksum="0708E88BC81E1C15" modified="2017-04-12" version="1">MDGFDEEAFKKFFPSGFGKQQKSVDIESQIDRTRRTEISASKPLTDAGVNAPATAGPVATEKRPQEPKDSDDDSDDEKDSSDEEDEDEFPVSHELVLKTHERAVTTMTVDPSGARLITGSTDCTLKLHDFASMTPSTIRAFKSVDPSVKKQSAAQDTHAVNYVGFNPLSPSHVLVVPATAQPRILSRDGETLTEFVKGDMYLRDSHHTKGHTSEVSSGVWCPTDENLCATAGSDSTVRIWDVNVGRSQKEVIVHKSRVAGSAGRTKVTAVAWGSPKQGGSNVLVAAALDGSLVMWSGNGPFNRPSGEIRGAHTRDTWTSGLDISADGRLVISRGGDDTIKLWDTRKFKAPITTVTHPSTSFRYPTSNIQFSPSSANVIVGSETGHLHILNPATLKPELVTPVTPGSPLITVLWHEKLNQILTGSANAETHVLYNPTMSTKGAALVMSKAPKRRHVDDNPTLTTDLSSGLSGDSVVVGSNGVPHYSSATFAARHPTIGLTASGRSRDPRRPHMPQVTPFAKSQSDEKYIRDNIPLSSMRDEDPREALLKYAEKAEKDPIFTRAYKETQPNAIFAELSDDDEPGPEKKKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC67</accession>
    <name>A0A1Q5UC67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="511"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="995" mass="110152" checksum="68A669EDBB1C80B4" modified="2017-04-12" version="1">MGSISQNSTVLRLLDAIHAQDPTALYCVHPVSSDVSDGWTDISIADLVSATSRFAYWIHTKVALADGPQTLAYMGANDIRYCAFVFACMRLRHTVDEIQVANPSLQSWVAPDFWELFDRQSPEPIIEEPADDPEDRVAVYIHSSGTTGMPKPVPMTNGYFIALQQICELPTPEDRVGSIVAVAGRGKRVLSVSPFFHLMGILNMMIPILAATPFVLTHEKPLTVDLLAEVVKHGQPKTANLAPSMLEELSTSELGMECLKTFDYLTFGGAPMAREAGDRIAEVVHLQSVLGSSECAIFGALKYQAKDEWPYLEFNPFAGYEMRDAGDGYFELVVVRHDQKPTLHAVFHTYPDKDEYQTGDLFTPHPEKEGLWLYAGRRDDVIVLSNGEKFNPITMEELISGHPLVARAVVVGQGRFQSGVLIEPDWESWNGEPSALVEEVWPFVKKANAAAPGHAQIMKDRVGLASQSKPFHLTAKGTIKRRMIVNDYADEIDALYVDADQVDVAQIPKNATQSEISTYVTSALCGLLEIEEFDKDADIFASGLDSLQTLRLGQILQASLKSARPDLGAAFSSPQLYSLPTIAQLTEYIYGILQGQDSAPATTVVETDDDRETRIAGLVGKYSEGFGQDHAVILTGSTGSLGSYLLSELLRDFSVTKIYCLNRSEDAAPRQLQSLREKGLTMLDQFPRRVEFIQAQFGAEKLGLDEAKYEEMLREVDTIIHNAWKVNFNHRVEAFEQPHIEGVRRLVEFSIASEKTAHIHFISSISTIEGYNKGPSIPEEIFDEPSSVLRQGYGESKHVSERICAMASAKCGVPTSIHRVGQIGGPTTDLGMWNKQEWVPSLVAASKTIKQIPNSLGSVSVQWVPVDVCAKVITDIVRSRRSTQEDEPCAAFHIVNPKVADWKSLIPAVTKHFDVEPVDIQTWIATLESFTNPTEDDLRDKPALKILDFFKAIAYSEEAGPSTETTKTQAASKTLRQLQAIDAPLMERWINQWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDA9</accession>
    <name>A0A1Q5UDA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-type alcohol dehydrogenase-like protein PB24D3.08c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000347">
        <property type="protein sequence ID" value="OKP10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDA9"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="37314" checksum="90A5C435C51FD06F" modified="2017-04-12" version="1">MANKALVFKEIPQGYPVPGQHLTVEPATYDANVAAPADGVVLQSLYTSFDPYMRGRMRPAEVKSYAPAFDLNKPIESASIAKVIRSNTDSYKEGDLVIGHVAIQEYVSLDGPNLARIRKLENPLGIEDIRVFLGALGMPGLTAYSSLYAIGKPKKGETIFVSAASGAVGQIVGQLAKHEGLRVIGSVGSDEKLDFIIKELGFDGGFNYKNEKPADALARLAPEGIDIYYENVGGEHLEAALDAMKNFGRVVVCGLISQYNSAPYPIKNIHNVLVKRITMRGFIVGDPDMGPIYTKEHQERVQKWIKEGSFKVLIHETEGIDNAAEGLVGIFYGKNKGKAVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDS0</accession>
    <name>A0A1Q5UDS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_3906</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDS0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDS0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000191">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="141"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="223"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="453"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="521"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="782"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1042"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="66"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="348"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="589"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="658"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="757"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKP10603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123469" checksum="3C0B814A50F5DCAC" modified="2017-04-12" version="1">MDGDELIASVYRKIEREKALIAAASNMRQSTDNVLVQQRVDANIRDGRKNIAYLEEKMRELQLRQMEREGGGSPHDSRNQQAGGPPPPPKDHQGYYGGEGDAQYPQGGAGSMPSGAPFSDPRPYAPIPKARPNYTKLDLIKYDTPYLGPKIQLMLSQLEFKLSVEKQYKAGIEKMVRLYQDEGDRKSRADAEGRRVESNQKIQLLKQALKRYEDLHVDIDSSDAADDESLSSPNMRKPLTGLLTMRIHAVKDVDHATSSRFSRGPETFVIVKVEDAIKARTKATRNDKWLDESFSIDIDKANEIELTVYDKSGDRPTPIGMLWVRISDIAEEMRRKKIETELNASGWVSADKMDGSGTPRSDHHPGSPGSSHGGPGGAGFGAMAAPGGHPHGDNPNAPPTVMIDSWFALEPFGRIQLQMSFAKQLKDRRPFDIGLNRQGAVRQKKEEVHEKQGHKFVTQQFYNIMRCALCGDFLKYAAGMQCADCKYTCHRKCYPKVVTKCISKANYETDPDEEKINHRIPHRFEGFSNLSANWCCHCGYLLPFGRKNAKRCTECALTCHAQCTHLVPDFCGMSMEAANQIIDAQIRAKHHNKSTSVSSGLSGRTLRPGGPPQPPHDNSVLSYPHKPTNGPYGALPRLPSAEAVSAATNSYMASQSPLAATQAARQPLPPKSPSSAVFTAKTAATAASAVRPTPQPPTEAPRPPVEPQQAPPPSHAHYDPKAYVNYQPSYQAPQVQKPSGPSYPVAPPPQTVQAMPPQMPPPQKEPEPPVPQPKARIGLDHFNFLAVLGKGNFGKVMLAETKSTRKLYAIKVLKKEFIIENDEVESTKSEKRVFLIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAAEVCLALKYFHENGVIYRDLKLDNILLTLDGHIKIADYGLCKENMWYGCTTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPTDAQEVMSHAFFRNVNWDDIYHKRVPPPFIPTISSPTDTSNFDQEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDX1</accession>
    <name>A0A1Q5UDX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDX1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="6913" checksum="D7CA4C430D24C50A" modified="2017-04-12" version="1">MSSIRSSCRSLPFTADSLWRILFRTVPLSWRWYMGGIAAAPAGASANVKFKAPRRIGKLSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFL2</accession>
    <name>A0A1Q5UFL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFL2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="21298" checksum="0E806E6FAA4152A8" modified="2017-04-12" version="1">MACETTDVIICGCGPTGALLSAYLGKMNISNIVLEKEAEITTDPRGIALDEDGIRLLQGAGLYSSVYSEIGTCMQKFKFIGGTDPVLDKRAFIEMDYGTTEGGTGHVGFICHKQPALEKCLRDAMASSKYCDLRSGCEVTSLSEDDQGTICQYRDATGEEHQIRSRFFIGADGKTGFTRKQYLEPRGILMEQAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG30</accession>
    <name>A0A1Q5UG30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_2921</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG30"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000007">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="17">
        <location>
            <begin position="144"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP11435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="303" mass="32928" checksum="45A8F29FD2BBEDDF" modified="2017-04-12" version="1">MDAKAIEAKAKALTKAATQNEPASTILSMLKEIQQGVKATEDLLRQTRIGIIVNKFKQHKSPEVARLSSEIVSKWRVEVSKQKQGGASAASRGSSSPRPAQNGTGASTPAAATPSDKASKLSVPPDKRTWKADGVDAAVTGNRVRDSCLGLMYDGLCLGSTESPKTVLAKATAVENAAYKYLGPETKEEYRTKMRSLFQNLKNKSNPNLRIRVLAGEIAPDDFVRMSSDELRSAEQREADAKIKKLNMDKAMVGQPERSISTSLQCGKCGQRKVTYTEAQTRAADEPMTLFCTCLNCGKSWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGQ6</accession>
    <name>A0A1Q5UGQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGQ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGQ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="268" mass="29360" checksum="E75721F8E1840499" modified="2017-04-12" version="1">MSKLKESLAGPGYVILNTIRALNIIVFLDIIAACAVMLVKINMYNGWFFFQAVTHAVIALISIALIISELPFFREFFNRRYPMFGEEAGFFALAAIMMILGVAVLGNLNTEVMSQQSLGLAFWRIIISAGILAMVVSLVNILATLIFTNRTQGLSARHVRQYGAVAPQKVVSRASSNRSFQASLNLKREEDSLPSYTPQSATKRFTKRLTGRFPIKISNPMNPTNNGTSLTAPPMNDAASSRYSRDSAGVTIPDPAHHPMYGHGASMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHY0</accession>
    <name>A0A1Q5UHY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_2444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHY0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="208"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="358"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="416" mass="45976" checksum="F6D66835A6227435" modified="2017-04-12" version="1">MDESDPLLSELCSICHINPPKYRCPRCSTRTCSLPCTRRHKLWSQCSGVRDPAAYLKRSELATEVAFDRDFNFITGIERSLERAERDVENRGIELARGQVPQGEEGQDDASSGTGAVSGAGRKRKHPTQGLVKGEAGFLRGAEAGLVKVLRAPRGMSRNKQNTSRWHPKHKCLSWTVEWISTAGEKTIRNALETYLISEAYDRAYPLPKQDRPVADSKKEKEVVQENTPTEQTPTATETPDTSVPTTTITTTEPTGPSTNPETTQTPTAPTEQKEKEPEPELPLTSHRNLYFYLHRPRTTTKKPVLAPLPPSTKLASALRERTVLEFPTIYALPDSPERLLACKESSLFILEEEYLGTASPEELGKATEGEEGEEDGTGAGNGDRDAEGTLGTNLEDVDEDKVLEVLKQDLFESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI17</accession>
    <name>A0A1Q5UI17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012524768" evidence="1">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="85"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="3">
        <location>
            <begin position="427"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="570" mass="61624" checksum="D469F1695B74C5DA" modified="2017-04-12" version="1">MYSLCLLSLLSLGAYVTAKPNACPILGPAFPAPTEIGRDPTFIAATQNLTAQIKQAIESGELAGNSISVQIFSGSDSYTAYGLSHTDHSVRNGSVGVREVDENTIFRVGSISKLWTMLLYMTFNGTKHFEEPVSKYVPELRSPYNSSQQIDQIEYVNWDEVTIGELASHQAGIPRDYAFMDLAAMAPPQALSRMGLPSLPKSERLPCGNAPFPPCNRQQFFNGILDTQPIAATSSTPLYSNAGYQILGYALEAIAQKPFHEILRERIIEPLSLSRSSHSMPNPTLAVVPSDLTSSQFNLDIGDAIPISAGGIYSSPKDISTLGRAILANTLVSPAMTRRWLKPATHTASLQVSVGHPWEIMSFNEPRLVDLYTKAGNIGMYNSIMALSPDHNAGFAILTAGNGSFSLPLKLSEQVVDIMVPAFEQMAKNQAGQRFAGTYALEDGISNSSITLVTDDEPGLKITEWISNSVNMGQAFAAKAGLQDTPSLLSMRLQPTSLKSPGRVSFSAVIQGLSEQTTSGPMLSACLTWLELDSYIYGNVGMPEFEFNLNKEGDVVSVTPRALRITLPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIT7</accession>
    <name>A0A1Q5UIT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Expansin-YoaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIT7"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22271">
        <property type="entry name" value="DPBB_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049818">
        <property type="entry name" value="Expansin_EXLX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041144">
        <property type="entry name" value="expansin_EXLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF21">
        <property type="entry name" value="EXPANSIN-LIKE PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886134" evidence="3">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="4">
        <location>
            <begin position="142"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="34920" checksum="6BEB4E8A7AC3390A" modified="2017-04-12" version="1">MYWKIAIACLAGLSTVVTADLHDQKEIENCPVGYALTTYVVTVVKNSTTTVNEWATSLPGANDWQATSTQDGIFTLSTSTPRPDETNKDAPKSAPTPTETSPSPTVVEPSQSLASSPPLSPSPLAGGVVHGQATSYEGGDVDGTCMFSTADYTLPAGIYGAALSVDNWDSAAWCGACLSVVGPSGNSVKIMIVNQCPGTCGLNNVDLLPGGFQQLADLKVGRINVEWEIVKCDISGPLFLKTQTGSSKYWFSIQVVNTNVPVRSLEVSIDDGKTWQSLSRREYNFFQNPSGFGVDFVDVRITSVTGETIVVNNVSSAAETRTDATSNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX2</accession>
    <name>A0A1Q5UIX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX2"/>
    <dbReference type="OrthoDB" id="3546893at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="896" mass="96610" checksum="D66005585B77EB2A" modified="2017-04-12" version="1">MLSLSAVVAIAASAAAFFVVLGVVVIVVWVRVRKERHAMRMLGLKEGDNPRRVKAYNPDTLTELSHQEGSVLRAHGNLPYGKPGEWGQLESRETLLRSESEPESSWPLMERARSLRNSIRRASSKRFTKSGLRRMGSMATVSEMLPSPTGTSKDDIPLSAVEGVLELPAERTPRQTPEIPGEEEGFHLGMRPMSPASAWPPPGQQQRAFPVLDNILSQNLFDPPLMIYEESPTRIRGGSIVSQTAGHAPDQSIPPPPPPAAFPQERFSYLRNDSVMRLSSMSLDTTNSSILEDGRNGPRSADTDLTSPIFPSGGSFVPFSANDVGVKNGRRSFIAANTSVPPNFLVRSSSTADGPRKTSEEAMSPRRSMTTASRNPSNASNQSTALPRRSESLSSTAPQRNSSLRVGTPGSMAAYQNDNRSSWRSPTSNLAHAPYVSQYPQQPPPVYESEQFENDPFYGGSPASTGTLFSVGSPSQPNGYMPQSPLQRSSLSIKGPLPSALKGSNSQRKSKGHRRQNCVRISIHPPMTFGGPAFSPTVEEEPEDLDAMEEVDLRESTINGTSNSQPSMPANTPSPLPLSKRGSGSRRTKPVISAPSSLGPLAEEPQPTLHTRTPSKKRKKAPTDNPDDTPVMAKGHTLPGLFTALPPVREVVLSHTPSPEREPPAWAVSDNPSPTTRENASGISTGSPRRPPLKGPRTQPGKPGRRNSTHAPQPKPTEPLMGLTSPTGLPVITGTQGSDWRKSTDSPQRGRTDTSTDSFRKNRDSQGSLVNGLDSSMRPMSPVYGSQVSTVRDKVTIWEDANRSASPPKLAATQFGAGYTFQLDTNLSPTYAKNSIPRTLSKSGNQSPIRMHSHRAPPTPTSVRRGMTTPTSKGLGIGVTCATPVSLYDGEGFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIY2</accession>
    <name>A0A1Q5UIY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein LOT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIY2"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33841" checksum="48FC8B35291FA6C2" modified="2017-04-12" version="1">MEVLHSSPEASSFVTIAEHQSRTPSSFHNGPPVLYYHSERCKVVILERDLLATPALNALRGESASTSGTSAAAAAQEDDDDEGPEVAIEGLHTWVTSEKFILYSPSTSTGVSIPYPSISLHAIQRLRIPGATDTEVQGLYMQIAIPTAPTSEDDEEQCITMTVVPPELTPEQRTAQEETSDETAETPTQMLYNAVSACSNLHPDPVEPGDEDEDDEESKHSFFQFGQEGMGSLNGDSLPPPVDGSSGWITADNMHEFFDEEGNWIAEGEPASFPGLGPGAGTVRAREEENGDGEGQDGEEGEGEGDETKWRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIZ1</accession>
    <name>A0A1Q5UIZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clock-controlled protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="537" mass="57299" checksum="D2A9DC2A56BF116E" modified="2017-04-12" version="1">MEADKPSGPIATDSPAASNLNKPPASSTYLVTTTGATAAAAAAPPPLHPPHPSALHNAHPAVMDLDTNTADDRSRRATSVISMDDLEAAQALEGLRSESCDAVAAVAAGTGIASALDKTSRLILHPPDFGQSPRASRQTLPATSPDPPQPEPLLSLLTSSHPLISSAINGSVSAYTTSKSYSARFKSGAEFIERNIGSPVANTVGTVGRKTGVESGLRWALQRRESGSESKPSSKRRKVSGEAAPQTVDDEKVSPENTMTPARTRSSSDLSMAETLPPYDEMRSPRYEEKPGRQNPPTWQSRLVISTSGLGVAMSEESLRSLQYCLTWLRWANGRLGRAIVALQNAMTEWENHKKQSQDDLESGDRAESAESASLLTQRIQAVRADVLSTLKQVVDVVSKYAGGALPENARHLVRRHLTSLPHRFQMASTSQPPPDSPAASSDATVGAHRILVLANEGLDILGQVSGVVNDTLVSAEHWCERLGRKRPDNKAAPDAEKQNHLPSPPDAQMYGADIKEPIVTQSAPQEDVQMTGTEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ94</accession>
    <name>A0A1Q5UJ94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Microsomal glutathione S-transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ94"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18697" checksum="47872619344E2852" modified="2017-04-12" version="1">MTSLLTAIGLRATNPLNSPIPNFGPAFLGFHFLWAYGVLSSRTLKQWYGIDHQVSPREDLAKYGEAAVRDGKITRKQLDMLKRNDAAHANSVENYSLLVGSLLFASYAGVPAQIINAAGFSYTIARLVYGGVYIFVGTPKWAWIRGLVWWWGNVSCLALLYQAGRRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJU6</accession>
    <name>A0A1Q5UJU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tubulin-specific chaperone E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJU6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJU6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="577" mass="64213" checksum="9069799D962DB86F" modified="2017-04-12" version="1">MWEVSRALQVTGSVLNGTTPREASIQESIKESGKSNYPTAGSFVRPSRPSYLPLSFLEALRDKYASENDSELVWTSKPLGQASQQTIEISGKVVEEVGFDKIRKQLAELQELRIVLLDGLRIVGVLSSYEQPEAEVLEAAKDIATTCPKIEELDLSRSLLSRWRHVWDICYPLKELKKLKVNGNRFQPLEDGFIFEGITELHLEETLLSWDEIAEVTSRFPSLTSLTASGNQLRTISRPLPGSIKKLTLENNEVRSLLALGPLSEIQTLEHLSIRGNNIDAVTDSTQLTALDFTFPPTVTSVDLSRNNISSWTILNHLPILFPGLTTLRFSGNPLYDQPPLPPAIAAATSSMSASKPMTLDESFMLTLSRFPASLKTLNFSTISPQDRSNAEMYYLSLIGKELSATSEAEEPAILAAHPRYAELCELYGEPTVTRAVERDGSGKRVIHPRSVATRLIKLAFQLSESQVCVKEIPTSFDSYQVKALVSRLFHLAPYSFRLVWETDEWDPVEKKTGDDGVAGWDEDSDDEMQATAPVSSADTSRFVRREIELDDSTRDIGFLFQGETGEMKIRVEVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJX7</accession>
    <name>A0A1Q5UJX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJX7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="253" mass="28505" checksum="C5C8165BA054E5E4" modified="2017-04-12" version="1">MAMRLAFDLGLHLDMSSYISDGSISAAEAELRRMVFWGAYTLDHMHYHQAIIHAHRPWISKSSIQPQPAQGPGHTHARKMCVDSATAIAKLLHLYELRYTFRRMNIQAVAITCSAALMLIFATILNRNFDHDHETVAHLSLCFRALEELGFSWESAKRAQSFLLHMQGLWETKVRPYRSAKRAMSEAHDKSRAQSPQNKRSRTSPQPGSGEINDSGDNLTLQDSHQKGDALLDCDSEDFDWLWAASMGAVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKC1</accession>
    <name>A0A1Q5UKC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKC1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="42521" checksum="DA0AFEAC789B2C2F" modified="2017-04-12" version="1">MDLDDDTLQMLKRRVHVFIHAACSIELKNSLRELSYTIIAPTLCLAKYALKFPNLEKFVFISSAYVNAHLWKTSDSCDVAVQERVYSLNRKSEDIHESAPEVWKEVQKNGTSHEFETNDFPWPYAYAKHLAERLVLHQASEKGALDKILIIRPSVVGPAEEFPYHGFTTSYSSPSTACAAAYALHPGRKIVLATRCENPDQEATIDEVPVDVVVDRLLLHTAVGTSGCIHAVSGEKRRLRLEDWWNAFKTERRLPWNVKPIWTKEDWHSSNLHHMARSFKIIGTSFAFAEDKTDQVVETLSPEELGQLKLFTDRSQPYHHSLIHRRHHIHHLAKEMVKKNKLPVPVFMIGLFCRKGKPPQHYQTQSEKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKL6</accession>
    <name>A0A1Q5UKL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_1128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKL6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKL6"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="243"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="302" mass="32213" checksum="D47FB812C739D993" modified="2017-04-12" version="1">MPTLLCLENPLLDVQAFGNQELLKKYGLKANDAILAEPSHQGLFDDLINNFAAETTAGGGAQNTARGAQACCPSSQSLVLAAQPHGSVVYLGCVGDDTYADTLRESCQKAGVRAEYLVDKAHPTGRCGVVITDKNRSLCTELGAANHYKLEHLKQPDIWSLVESSQIYFVGGYHLTVCPEAALALAEEAAAKNKIYVMSLSAPFIPIAFKDALDKTEPYWDYLVGNESEALAWAQSHVSGTPGHEEIPVRKISAAEIIDTTGAGDAFAGGLLAGIVQQESLKTSVDMGHWLAQLGIQQMGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKY4</accession>
    <name>A0A1Q5UKY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKY4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="21033" checksum="D005020E1BD9A0F8" modified="2017-04-12" version="1">MSILRFYTNLKSHMTEHKPLTKLLAFKMVVGLVFLEKKFNMSQIIFMILHSTDVLKETSKLTYADVYIGLPTMLICIQMVPFAFFFLFAYSTKPYRVDGGNLRYGNAQEYLAVEETEAGRTYKPRQYQGGPLGIYAWLAFFNALEFFREITSTYSMFREGRIRSADPMQSQESYRMQYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULJ3</accession>
    <name>A0A1Q5ULJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULJ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="295" mass="33001" checksum="DAFD24166D788155" modified="2017-04-12" version="1">MSQSIYEKTSQNDITKHRDQMVETPTRVNPPTNLRGNTHQPVSTPVDMSHSESGHLLASSDQTQLLDWDVQWPFYGEGLPDVNLGWTLDFLSNDASTHSPLDFMHDHDETNASIQLDDSTLNLGGNEDLRGIGRAETNDDEPGGRQPRIQPRENSGSAAYLDPDEIDNAFFTNPARLNPNVSLSRESHMSMMETVTAPLLEAFCSDKGKCAQSFPPLPVISYFLQLFFVHVQPRFPVLHIPTFNPNNCSPSLLLAMAIVGSTYSESNQCKFALTYLARARTSIKLMQERDQSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULM5</accession>
    <name>A0A1Q5ULM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULM5"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="43"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="406" mass="45187" checksum="E93D1397FF2CBEF5" modified="2017-04-12" version="1">MWMGQKAAYERAECDRGDLAVYCRRGQMLDCRMKPNNSPQLPPRSKRNRLEEAWAKWINVEQKKRLGLCIYLLDCQMAAVFQRQPYISKAETVNASLPCSETFWNAPTAWAWKALLGPAEIPPSTYFLTTLTTILLHHEIPVVLPFPALDGFCKTLYAYVLHTHVFEWRQTICMLNPTGLLTSPISLAPENIGSSLQERRNWLECCLKNWATWYGDGDQVEPTDHNSKSSSGILLYHLASLALHLNFSDLHIVAGRSGSDADIGLAVQSLRNWLQGQRVQRIFACNSQMLNAAHEAIAAGDAQKSGFELAISLFMGGLTSWAISRFGNHDLMTAHLSAPQTSGVSRTEPDSDENRDQLSAEESPQAVNLLFDQVAGARDGLHAVRCVRLAVSFGEILDGLLTEPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULX0</accession>
    <name>A0A1Q5ULX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="236" mass="23991" checksum="9E9C266895F09994" modified="2017-04-12" version="1">MSSYLASFTSSSSISNVLGSRLNSLRRAITLGDDKDDPENEDCSHISNALRAYYTEKGRPFPSWLPPDPKAPASAAPRPIATASSGQYGQAPAGAYGRGGGLGDLWGDSGAPSPGSAQTSSLRRGRGSAASGASGSGLTPAQSAPPGPVNSPPPQLSHAQSHSPSSGGLHPAGARPLPSQRSGSYQSTQSGRSSQDSRSGAGSAQERLRARLHGGRSPSPGNIDPSVRKPVGGRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM33</accession>
    <name>A0A1Q5UM33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM33"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="38647" checksum="C99260A44F64DC51" modified="2017-04-12" version="1">MALGPTISIPPKEAQAAIDNALEKVSKQLRELNHYIWSNPELAYEEHKAHDAICDFLESQGFTVTRHAYGVDTSFECISGTEGRLVNFNAEYDALPDIGHACGHNLIATSSIAAFLALSHLQKEYGVKGRIQLLGTPAEENGGGKAKLIDAGAYKGVDISLMSHGGPTNLAGLPSDGVAGVLMNARKELHVEYFGKNAHAGGNPWDGVNALDALVQAYNGISTLRQHILPDERIHGAFLDVPKVANVIPAYTKSYWQIRSPTLQGLNKLIAKSQIVDTRKGNVSYVAPTLHSMFAIPTPEGAFPHHPSFAASAGTDEAHEEAIFTGKGLALTGWDMLCDDGLFELAKAQWEGQLPAPAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMP2</accession>
    <name>A0A1Q5UMP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMP2"/>
    <dbReference type="OrthoDB" id="5069333at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="569" mass="62726" checksum="14CED12F4DAAA20E" modified="2017-04-12" version="1">MPRRKAADRTGQVKTRSRSGCQECRASRVRCDTKKPVCTRCAEKGLPCSTNLVLKWESEFVSRGMAFGRAGVWSKSRTDESSPSGSSASSPAFSLDDMRQWCTLPSIHPWAFINSGMATFDNPDQIDIALNEQLAVVPFINRHTMIAGEASDRPAFNICSIRNIGGLATVLSPGPAHGPSLFPGISSIGHTELFDYYLQQVCPRATASSTMSSPFASVILPFSVSASPTLFKAIQSLAACHWARQDPNYSTLGLRLKSETLRDLRRRLSYEGSVTCSNDPEVLLIMMMLCLYEILDKCDEHWTIHLKGAKDLIRLRRQQVDAVSDPVTTFAEHFFAFQDVMGRTACGEAVLFGSDYWKTDDKHIDLWMGCSPELVAILSSITELSRARRELQSGNSSTLFSVRAASLEYQLEHLVQEVGDGDDDILVSVAEAKRLAALLYLHCALYGASPTTPLVIDFVYKILHLVSDLLERESMASVMWPVFVAAVELDPSRDELWSGPDGQPVSGRAIVLQALAAMADSTISNIARTRAVIIQAWQGRDQDLLKAPHMEMNDWETYVAPISTSMSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMW8</accession>
    <name>A0A1Q5UMW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMW8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMW8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF9">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="251" mass="27734" checksum="3B1E94904298653D" modified="2017-04-12" version="1">MGYVSWLGKYDTTESVLVTLLRKAGAVFYTKTSVPQTLMVCETVNNIIGRTLNPRNKNWSCGGSSGGEGAMVGIRGGVIGVGTDIDINASGEPSIPNIKDLLNPDIQQIDMNQLWDTHLKKWNYQSEYLEKWRELEEQQGKELDAIIAPITATAAIRHNQFRYYGYASVINLLDFTSVVVPVTFADKNLDLKKKDYQPLGDLDATVQAEYDPEAYHGAPVAVQVIGRRLSEERTLAIAEEIGRLLGNSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN67</accession>
    <name>A0A1Q5UN67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Picolinate carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; quinolate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN67"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001760">
        <property type="term" value="F:aminocarboxymuconate-semialdehyde decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF27">
        <property type="entry name" value="2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="32"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="400" mass="44485" checksum="BDF37F8C4FC76BCC" modified="2017-04-12" version="1">MPINSSCCSCNSGQQRWAGTNEPPSSNAPLRIDMHTHIMPPSLPDFSKLYGSREENGEDWMNLRSHCLSGSDASGQTGAASSKVDMYVGEKFFRTVEPNCFDPVVRMKDMDATGVDVQVISTVPILFSYDKPIEPAAALARYLNDHIASVCQDNPRRFVGLATVPLQDVPSSVAELRRAKVDLGLKGVEIGTEINSCSLDDPKFDLFWEACENLDMPIFVHPLGYELERENKSRWGNYWSAWLIGMPSETALSIHAILSSGVLVRHPKLRFCFAHAGGAYLPLLGRIQHGYNCRPDLVAHRSEGVSPQNYLESHQHNIWIDSLVHDPDLLQLICKKIGPDRIVMGSDYPFPLGEMPNPGEMLSSDKKVGELFSSKTRARMLAGNAIEFLGLEDMYQNFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN81</accession>
    <name>A0A1Q5UN81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN81"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9536" checksum="4EEFF6FD9828732C" modified="2017-04-12" version="1">MYEPELVDMSNASFNSLHAFFAIKFGHECILDTIQQSTFVFHQSEPGNPTIVNDASKAFCNGMMRVRLEALVDFSLMEWLLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNM7</accession>
    <name>A0A1Q5UNM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNM7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30811" checksum="A18A0D80DADF894E" modified="2017-04-12" version="1">MSFQLPTFDELPPVEGMPQGCAWGIFDKDGRNDIFGTLNLLTPEVVKAATAEVRKGISVSLNWSLESIKNPEFFRKSLSHKVMKLEDGETEWHDRGCIVGRGVLIDYKSYADHKGIQYSPFSSHRITPSDIETVAAYQGTKFQPGDILIIRFGVTEVLGKLNAEEQAAAMSTHHACGLEGTEEMARWIWNNHFAAVASDNVAVEAMPPMLDGKEQPLTQLVLHQWCLSLFGLPLGELWYLKELAEKCRDERKWTFLLTSAPLNVPGAVGSPANALAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNR4</accession>
    <name>A0A1Q5UNR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PENSUB_216</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UNR4"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1133"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1253"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1276"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1314"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1098"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1400"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1416"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="762"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="803"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="826"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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            <name>ATP</name>
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            <position position="1052"/>
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        <ligand>
            <name>ATP</name>
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            <position position="1072"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="1075"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="1076"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="1076"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00050913"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="OKP14110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1511" mass="170045" checksum="6479F869F0C91192" modified="2017-04-12" version="1">MASVQFTGDDNNEGVHESNEVQEVSSNISKPTKRQRWATTRHTGSGGVRKRVSIIDRFHKRSEMRDEKRKSATPSTPAASTNGEDSQQSGPNRTIYFNVPIPEDERDEDGHPIHTYPRNKIRTAKYTALTFVPKNIWLQFHNIANIYFLFVIILNFFSIFGANNPGLNAVPLIVIIVVTAIKDAIEDWGRTVSDNQVNNSPVYRLVEWNNVNSTEDNISLWRRIKKASTRSAISTYHWGKKLFTKKKDQDGDLEDGQRRDSFLTTGDPRASIYSHRDSLAVDAAIPMTEVQSPQAEVREDWPISSVPENKYLSPNSALRESVMSPTSLDKKTGSVLDKTKQTPGTARFKRDYWKSIQVGDFVRLYNEDPIPADIVILATSDPDGACYVETKGLDGETNLKVRQALHCGRQVRHARDCEKAEFTIESEAPHPNLYAYNGAIRWDQRDPNFPDAPRKEMVEPITINNMLLRGCSLRSTEWILGVVVFTGGESKIMLNSGATPAKRARLAKELNWNVIYNFIILFIMCLLAGIVNGVAWAAPDKSLDFFDFGSYGGTPAVTGIVTFWTALILFQNLVPISLYISLEIVRTIQAVFIHSDLYMYYEKLGLYCVPKSWNISDDVGQVEYIFSDKTGTLTQNVMEFKKATINGMAYGEAYTEAQIGMRRREGANADEEAAVARAQIAADGKKMLEMLRRIHDNPYLQDENLTFIAPNFVADIEGQSGQTQKAAVEHFMLALALCHSVITEHTPGDPPQIEFKAQSPDEAALVSTARDCGFTVLGRAGDDLLLNVMGEERTYTVLNTLEFNSSRKRMSAIIRMPDGTIRLFCKGADSIIYSRLARGKQQELRRQTAEHLEEFAKEGLRTLCVADRLLSEEEYQVWNREHDIAAAAITDREEKMEEVASKIEQELMLIGGTAIEDRLQDGVPDTIQLLADAGIKLWVLTGDKVETAINIGFSCNLLNNNMDLIVLNIPEGQHEQAAKELDKNLQTFGLTGSDEELIAARSDHSPPEPTHAVIVDGETLKMMLDDELKQKFLLLCKQCKAVLCCRVSPAQKAAVVNMVRHGLNIMGLAIGDGANDVAMIQEADVGVGIAGEEGRQAVMSSDYAIGQFRFLQRLLLVHGRWSYRRLGECTANFFYKNLVWTFTLFWYCCFNDFDGSYLFDYTYIVLVNLAFTSLPVIFMGIFDQDVDDRVSLAVPQLYMRGIERKEWSQLKFWMYMADGLYQSVICFFMPYMLFQVANFATENGRDIADRTRMGVLVATCAVLASNLYIMMNTYRWDWFTCLINAISSLLIFFWTGIYSSFTGAGQFYNAAAEVYGALSFWIVLLVTIMIALLPRFMYNSIQKVFFPLDVDIIREQVTLGRFKHLKQYEDYVPPNVGAAAIVGSGDGSATSSEIAKPIQPAVKQDQPDPEGAQQYYAPSQHTNGHNPRSQNGSNGTNYTESLDQCPRPQSVDYVRRSHDRTRHSFERIRHSFEQSNDFTSAARLQRMESSHTQHSNQDPFRSPGEPPAHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP06</accession>
    <name>A0A1Q5UP06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_69</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP06"/>
    <dbReference type="OrthoDB" id="10456570at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="21903" checksum="7D6AF737CB9EA825" modified="2017-04-12" version="1">MDNLPRSEEDLAVDAILFLELRKRIIQDLDQHRANFRLIWPHCDPKQEAINQIRLNLHTQIENLGEMLRVSPLPFGERLYKCTGKRHNAIVKCLNAVMNLTGLDGSARECEMALNFISQRIGGFRIIGVCDETADEMDRQARELWNQYGAGKKYGSMMPMTYFKIDEFNHIIPGMYFTDIFCTCPWCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPB7</accession>
    <name>A0A1Q5UPB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_14106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPB7"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="354"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="53144" checksum="6F2BCAF96569EB1D" modified="2017-04-12" version="1">MSLEPPTYLSSLQNNIRARPIPWEGAVRAGNITDDHLKKIKAVDKVRKEQRIQTIEADLAGYTSLLAGGSQGKSVLELASRRTDIVQYILVLASDLIQDVPALADSLVSHPEPYKPFLPFFQISTNAEDPIPLLTSTFLTALVSHSLVTSSKPAQRDEEALPQLYLYLSTLTKNHDSGLQDIGVQGFSELLRKKHSREIFWNHRKETLDPLIETLRAAAGTKDNGSTTGSSTRGIEPGLAGGVGLQLLYRVLLVIWQLTFESSLVGDELQESYEIIQLYTQLLRLSPKEKTTRLLLATLYNLCVSNRTTLLPVAVFVRLPALLTNLAGRHLTDPDLLEDLNGLSTMLDEYTKTQTTFDQYAAEVQSGHLRWSPPHKNPTFWKENARRILDEGNGALPKKLAEILSKDWENDKQVLAIACNDVGHLVKELPERRTQLERTGLKTRVMELMADKDESVRWESLRAVGEWLRYTFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPH4</accession>
    <name>A0A1Q5UPH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromodomain Y-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_14148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPH4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF3">
        <property type="entry name" value="PEROXISOMAL D3,D2-ENOYL-COA ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="183" mass="20125" checksum="E7EBD7320FEA61E9" modified="2017-04-12" version="1">MPSYQYTDIKVEMKGQIGVIKVFVLAMNGPGVGGGAAWFQGLADIILASETTYLQVPFNSLALVPEAGSATNLARHMGVHRANDFLMFGRKLTVQELENWGLVNRVFPVEGFHNSVIEFLEKQLEVNDGISMMETKRLQNLPLRSERILAVYNATDALAERLASGAPAARFRAKKAELEGMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ36</accession>
    <name>A0A1Q5UQ36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ36"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="10702" checksum="AE5C9DA93DBA5CC0" modified="2017-04-12" version="1">MGQMGLVPLKEPKDMQKVDVVNPWMKWRKRGGSSAKPLRGQRQTRLTSETPLGLLLTSPASGVRYINHLGRMLQRIVDRLEILQIATGHLMNVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQB1</accession>
    <name>A0A1Q5UQB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQB1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="243" mass="26995" checksum="B1597B29264CE051" modified="2017-04-12" version="1">MPPEHRILALVYQDFEALDLFGPLGAIVPRSDYYTLQLVNVHNLPAPQGLETSIKNSIAVIPNLLIADALKDTEHFDTLFIPGGLSMIHLLDDPMLLKKIGHLVDRAPNVFTVCTGSLILAATGRLNGREATCNKRIFDEMTPKYPGVKWKKQARWVEDGKFLTSSGITAGIDAGFAFLAKTYLAPECRNSVKQVSRPDGEEAILLRFDKEKALEHARSVAWSLEYQWNEDPTNDPFCGETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQI6</accession>
    <name>A0A1Q5UQI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mitochondrial respiratory chain complexes assembly protein YTA12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_11490</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQI6"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="433"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="854"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP14732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="887" mass="99044" checksum="6C083EA8A8C2BD1D" modified="2017-04-12" version="1">MASILRRPGNIARFSRRATECVGRAGTTSLRTHPSRLSSLITSSRIRTYATNGPTPPNDNSGNSPPKGSEPEKGHKEDEAESVLSTEDQTKLDAFTKHLKTRMPDSQHEAIDTLRKHLMKNGMPDEVKQFIEKHANASLMDHIRMMRWLFKYTSEQAKEDVEEYKKNKDGENDQVNKNTEEKKEGQEESEQKSKEKEGKGNEKETKDQKKKKQDQGAAAPRVFEFRFDPASFLVTAFVTYYVYRSFFPGESGGGREITWQEFRSNYLDKGLVEKLTVANGHRVRVDLNREVVNQAYPDSAGQPVTHVYFSIGSVDSFERKLEQAQYELGIPNHERIPVAYVDEVPWGSALLSFAPTLLLIGGIYWFSRRGGAGGGQSGIFGIGKSRAKRFNHETDIKIKFSDVAGMDEAKVEIMEFVSFLQQPERFQRLGAKIPRGAILSGPPGTGKTLLAKATAGESGVPFYSVSGSEFVEMFVGVGPSRVRDLFANARKNTPCIIFIDEIDAIGKSRSKSNFGGGNDERESTLNQILTEMDGFNTSEQVVVLAGTNRPDVLDKALMRPGRFDRHITIDRPTMDGRKQIFRVHLKKIVTNENMEFLEGRLAALTPGFAGADIANCVNEAALVAARENADTVVMRHFEQAIERVIGGLEKKSLVLSPEEKRTVAYHEAGHAICGWYFRWADPLLKVSIIPRGQGALGYAQYLPANGDTYLMNVNQLMDRMAMTLGGRVSEELHFDTVTSGASDDFNKVTRMATAMVTKFGMSKKLGYIHYEDDSGQQFQKPFSEDTARTIDAEVRRIVEEAYKQCYELLSSRKKEVGIVAEELLSKEVLGRDDLIRLLGPREWPEHAEFAKYFDGKGGETIAPPEPKVDPEETTGKDGRDETPLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URE7</accession>
    <name>A0A1Q5URE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotically up-regulated gene 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URE7"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="53"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="31300" checksum="C934633777677EAB" modified="2017-04-12" version="1">MAPPTATETVSNIAVQAPQSSQTAGTEKAKVKMQMPSMPKFEDKMQEREYLKGRLAAAFRIFGKNGYDEGVAGHITLRDPVDPTTFWVNPFGTAFSLIKASDLIQVDHAGKVIDGGPNRLLNAAAFMIHSAIHAARPDVLCAAHSHSLYGRAFCSLGRPLDIISQDSCAFYDDHVVYKQFNGVVLAEEEGNNIAAALGNKKAALLQNHGLLTVGKSIEETVFWFVSLEKCCHAQLLADAAATGRGGQTVKIDDADAAFTYKTVGTPLAGWFSAKPLFDVIHKETNGDYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URI4</accession>
    <name>A0A1Q5URI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF6">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP15085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="322" mass="36042" checksum="C853A2C2D11CE1CD" modified="2017-04-12" version="1">MVGVPRSKGCRTCLERRVKCDENFPTCKRCDKRGLQCPGYNRPRKFYHFIGPSGEQLTTSGLPQYIIDDSVSLRLNRTACVTQQKEAFGLFVDTTFPGLYYAWSSRVDVNFIEFVRQQDDSSFGALMLGARILGTLHLGRLYKDEDKIASCRSMYSRGLQCLAELIRNPQTVKSDHTLGAAVLLAIYEILDGTGQNSWLTHSRGITALFRHRGARAHSHGVGHMLLIAFRSFIVADALIRNEPCFLAEPEWRSIIKVSVRQEGLLGKGSKLGDLIEYSFHDITIIPGLVSKSAAVDMSRIRVIAYFRLRAIFVARPVPAIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMI6</accession>
    <name>A0A1Q5SMI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Asp hemolysin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMI6"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15359" checksum="FF0E6CE6C90FE1DF" modified="2017-04-12" version="1">MATTNQYLDIIIEDDMKYDIRIENAQMESGEFYRLGNPNDVLTTDDINDMSIRHNGGSREICSICEPGSMLGPSGAIDLVDDVRDTRICTLTWHATLKPGEHNSFLIRNQDPKYRVDIGKWNESGPIGEVPVSVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNE5</accession>
    <name>A0A1Q5SNE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNE5"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO89529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="9994" checksum="C8C910E5707AC4F6" modified="2017-04-12" version="1">MSDLKSILVIGGTSAQGSSVVKALSESGSYSVRVLTRNSASDQAPKLAARPNVTLLQGSQDNQKDLHSAFSGIYGAWVNLDGFTIGEKSELFYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNT3</accession>
    <name>A0A1Q5SNT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_13753</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNT3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNT3"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="268"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO89687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="38065" checksum="8E8E722FE94CD71F" modified="2017-04-12" version="1">MAASFLIRTPCSSANIGPGFDVIGLALSLHLDIHVTVDPTKGSSTLPLNCAITYEDQSKSTEQISLDPEVNLITRVALYVLRCHNQRAFPVETSVHIVNPIPLGRGLGSSGTAVVAGVMLANEVGKLGLSKDRLLDYCLMIERHPDNVAASLFGGFVGTYLNELKPEDVARKEIPLSEVLPAPAGGIDTGFKPPEPPLGIGHYRKFDWAPEIKAIAIIPDFVVPTANARNVLPQTYTRADVVFNLQRAALLPAALGSSPPDPDMIYLAMQDKVHQPYRKTLIPGLTEILQIMTPATQPGLLGICLSGAGPTILALATDRFTEIADRIIAHFATNNITCQWKLLEPAQDGATVTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRI5</accession>
    <name>A0A1Q5SRI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino-acid permease C15C4.04c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRI5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="58778" checksum="58461D525AE6628C" modified="2017-04-12" version="1">MADMSTKEVAEGSQLRQRHHEGRQIEIVGPDGQHRKVAVADLTQDDSELATRFGYNPVFKREFGYLSTFSFAVSISGLFATIMTTLSYPLLAGGSSACSVAELVSAYPTSGGLYFTISRLAPNTWVPSISWVTGWLNLLGQVAGVASSEYGAAQMLLAAVSMSRDFNYEITANTTVGVMAALTVITGVVNSLSTYWMEKMTKFYVIFHVCVLVACSIALLVLTKDKHDAKYVFTEVRSESGWTPIGFSWLFGFLSVSWTMTDYDATAHITEEINTPELKAPWAISSAMLFTYVAGFLFNIVLCFCMGDPDEILASPMAQPVAQIFYNSLGKGGGMFFTIAGLIIIKFVTFTAMQALGRTVFAFSRDRMMPFSNVWIKIAPWTGTPLYAVWMSVFFCIAINLIGLGSYTAIAGVFTVCAIALDWSYCIPIFCKLFFGKFQPGPWHMGPLSTIVNIWACLWTLFVSIIFVLPTAMPVTAETMNYACVYLVAVLLFALVYWYIRGRAVYTGPVTEAISDEISENEIVEFEKAAKGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSZ0</accession>
    <name>A0A1Q5SSZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon-induced GTP-binding protein Mx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSZ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSZ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="591"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO91121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="727" mass="82035" checksum="31F2E938DFC92757" modified="2017-04-12" version="1">MVLRNFHTDALRDICTEEQLDLLNSIDTLRSQGISHYISLPQIIVCGDQSSGKSSVLEAISGVGFPVKSNLCTRFPTELVLRKHSHVGVRVSIVPHHTRSDSEQRSLSDFCEQLDSFEGLPILIENAKGAMGITTHGRAFSNDLLRVEVSGPDRPHLTIVDLPGLIHSETKQQSAMDVQLVQDVVQSYMKEPRSIILAVVSAKNDFANQIVLKLARDADPSGKRTLGIITKPDTLAGGSESETMFVSLAKNQDVEFRLGWHVLKNMDMDKGHRSLDQRDAEELEFFSQGIWKDLPSSLVGIDSLRPRLSKVLLSQIATELPSLIREIEDKTNHCSTRLQRLGKPRTTIDEQKSHLLNISQSLQELVKAAIDGTYNDPFFGDAHFTKGYHKRIRAIVQNSNEEFAERISRGGHYRQICEPNDGQIPAKHQVSVTREEYIKHISHLLKRTRGRELPGTFNPMIVRDLFLEQCSLWEQLTRSHTDGIWAAAREFLALVVKHVTDEGTSTALIDEIIVPACDSIKQEIDSKTREFLKPHQTGHPITYNHYFTETLQKIRVKRQEDELAKTLQRFFRVDSLEEPYYVQHSINLDQLLKSLVQESEPDMVALKRFVDDIANEVVEGRLMSSLSRILSPVTVFDMPANLIMRIAGESKESQTVREQLLKELLILTKGSETCKRFVKTKIDVPWCLVWEDAVFYTNEADLPTNGSLAIPTCISFFAANCMLTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUJ7</accession>
    <name>A0A1Q5SUJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_12983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUJ7"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072354">
        <property type="term" value="F:histone H3T3 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000961">
        <property type="entry name" value="Putative serine/threonine-protein kinase haspin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024604">
        <property type="entry name" value="GSG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24419:SF18">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12330">
        <property type="entry name" value="Haspin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01331">
        <property type="entry name" value="DUF3635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase haspin C-terminal" evidence="10">
        <location>
            <begin position="481"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO91576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="655" mass="73581" checksum="CC250828E1BB485A" modified="2017-04-12" version="1">MSTRNSSSLTGHATPMEPRKPTTRTVSQRKVYGKRRNNAPRAVFEKNSPARAKPVPTDMNDTVEALQTKLAKVSINDELVPEQQDPDTASQVNEIQEDGTIEDALLAQLASSLKITPESINSSSESSPPKAPASKQRFYETMVEVRIYQQAAKKRSSNTEKLEGDTPAIERKTPRKKKTHPSARRSSGFVHDTKANAYVRPILNEALSPIASQSIQKFSTWASRSATMFQVAKLAEGSYGEVYKLHLRDEASRPPVSKSKLARLRAYGDGVFKVVPLCAQRGPRSKNFTSIAEIVSEVKMLKYLDPIPGFARFREIHVVQGRFPESFQSAWDHYKETKDDCWNPDPSSKKAYPDTQLWAIIEMDDAGCELEKFCWSSIFQIYDIFWGVAMALARAEEYAMFEHRDLHLGNVCIRSARPDGKMNPPTELDIARQSSPSGFGYSCLETTIIDYSLSRADLRLADLPDDPEGIVEIASSDLDKRQIFDAIGEDEDEALLRDTYRYMRATLYTGNPTETEKTPDIPGIWAEYVPRTNLVWLLFLLKNLLKNRKPEPTEPVSAPQRRALASCSPNLAMSPQSKGKAPKAKDISVEGDLVRQRQTKDIHARVSQLKQTLEDRLKDVLGLLDLEHGHEDMCCAADLVAYAMDSEWLAKQDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVN0</accession>
    <name>A0A1Q5SVN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVN0"/>
    <dbReference type="OrthoDB" id="4269539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011959634" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11026" checksum="371FB350ACFD4D5D" modified="2017-04-12" version="1">MRVSTFIVALATTLAVESAAKKINMSCKFAADHTGMMQYPFCCRDMKPARNNAKANEAMDCQQLTEPQLCEDQSRPACCYTIGPKKICTSHVIFQDAADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWA9</accession>
    <name>A0A1Q5SWA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWA9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052777">
        <property type="entry name" value="Acetyltransferase_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43305:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="20364" checksum="94EEF59A6A7A761B" modified="2017-04-12" version="1">MTVIIEPAQFPADTVAIHSLFSGYAASLGIDLTFQSFDDELNSLPGKYATPQGGALLVARAQSPDTDTTDHAQPVPQPSDEPLTVPQINSVVGCVGLRRNDEHWCEMKRLYVKPETRGLRLGDKLVEAVLVQAKALGYRGIRLDTLPDMVAAQRLYRRHGFFEIEPYYDTPLKGTIFMGCDLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXG3</accession>
    <name>A0A1Q5SXG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXG3"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="702" mass="76890" checksum="4F92258B0ADA001F" modified="2017-04-12" version="1">MSSVSATTQQGPVEARSLSSITAIASNPPAYPRNPTHEKHDPLQLYIVRVPGSQDIFLSPVKPPTKSSVSAEAINASLYYLHASTPEDDALLQEVELEREKQLHRRKEGLEAASIDDPTHRDLARLNNVRRKPVGGEREPSGQENTAISMAVTAPALAQENVAPPRVPRRPVPGPQVSAENVSFVGTPVSNVQPEVMSERRQGSADSMGNPVPRRPLPPVPPNEEPLIYDAFSGDDHPRKSNRWSAFMDNVQARGKEVWKEKYETMSAGRHSLDANRPQLPPRPSHDSSRSPNRSPGQSPTRRAKSHQASRGNAGFHLTLIRRDPASGTQWNVATISTPRLDRNTVDIEISTPGYNRFAGSNEPLSLASLAANLPPEMLKSAGSSLAASLGLEKPTEKQPQTKTQPQPSGPRKFHRQLCVSRQFEDPSGGIRSTLDSGNGHVPEGSKLKSGYYVFNSPWNGTCTFSSSVNGRSLKCKHMISAPGNAPPGDNDSNPAVTVAEIRFNTPFQAANLHFHASQRQHQQHQPHHHTHTHYSQTSNPTATPTSPRHNPDPSNPDTVPKRNSLSQFLNPNNLSRPRAHSGPNTPYTPDTTTPSTRTPFSPTNLIRRTSLRTARFSRHADFRHQYPAAPPRPRRSTSTSSGGQDSDEDRLDFSLARELAGGGMRGKSAKLGKLVVEDEGIKMLDLVVAACMAVWWRGYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXQ0</accession>
    <name>A0A1Q5SXQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXQ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="12919" checksum="C4213085F1828380" modified="2017-04-12" version="1">MDVVLAGRVGPTTKKATRPTHKIPQSLVDSVRVAHKEEFNPNKRLCFQPPETVYTMKEIGLEGHGISSIAASKPFPLFTAEAIKQIRAEVFSEPVLQDCQYTSSFTKNMIRGMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXQ2</accession>
    <name>A0A1Q5SXQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXQ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXQ2"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047974">
        <property type="term" value="F:guanosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF161">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="18330" checksum="37FB8430F415A8CD" modified="2017-04-12" version="1">MALSPLTPAQLNAAAAKCLALQTTAQDIHNKRPFVALLLAPDNETQLMSSLSLSHVRHAECELARNAADNYSWDYLGGCTMVSTWEPCAMCAGALYWAHIGRLVYLASEKTLQKLTGDGNTENLTLDLPCHRVFEAGQTRVEVLGPLEGWEGKVVEDAERYWSMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ01</accession>
    <name>A0A1Q5SZ01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ01"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ01"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011982002" description="Isochorismatase-like domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="238" mass="26051" checksum="24170C4ACB651A50" modified="2017-04-12" version="1">MYFSKIIQTALLLAVSAVPAQAWNRLDKKNAALLVIDHQVGLAQLVRDFGTNDFRNNMLAHSSIGNIFDLPTILTSSSDGGPNGLLLKEITEMHPNATFIRRQGEVNAWDNADFRKAVKALGKKQLIIGGIVTEVCTAFLALSLIDEGYEVFANTDASGTFDVKLAEDANRRMEKAGVTLMGFFAIVCDLMRDWRAKPGLTEILPVLDQYQFAYGMAARHHAGAIVNGTLAEVEKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZB0</accession>
    <name>A0A1Q5SZB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZB0"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="28912" checksum="B356434D9076E79E" modified="2017-04-12" version="1">MTAPHLDPDEVILVPKTFLHPQLEENVVNRYKKLRLHGLRVDPQSFSSTYEDESQFPDSTWLSRIYNPVGKTFAAVTNPDNQPEASTDNIPFHALGTNDALQSLLRKEWVGIVTLLGPGVFSRPNESVATELSQPYEVFIRDRKYQTPLTTSELGDLSGANLVYLVVGMFVSPSARRRGHGQRLMDAVLAAATEEACMLGARKVSITVQVESGNLGAKRLYERVGFKVVDEGVVIENRLGAKSTVVCLEMEVDIASREPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2R0</accession>
    <name>A0A1Q5T2R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2R0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293399" description="Hydrophobin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11797" checksum="CCBD67C8637ED954" modified="2017-04-12" version="1">MKFVFALFFFVATVLALPQNETGNVCASKQTVVCKSQGDGGLIALGNVLPGALGQNCAAGDVYCCSYDDVQQLKFGESLSGEPDRADNEWEAEKITGAIEIQNRLGLQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2W4</accession>
    <name>A0A1Q5T2W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2W4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2W4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="17238" checksum="B37EC986DDF16A8E" modified="2017-04-12" version="1">MAEYDRLKRIFQDHQSAIHDKLINIMSFRATVCIKEMNKIKWDDEDEVQRNVSLHIETLTKEVLTLHRVLSKHLPTVTVSMIVGQVFTNYKEQWSKAFEGAAIQTEARKARLLRDAELLESKLGKIDGGQVLGVHIINIVKAKSTSESRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T414</accession>
    <name>A0A1Q5T414_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T414"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37418" checksum="7F0D532F89746D95" modified="2017-04-12" version="1">MEQASRWQLFNTSWTLHRLSPLHHAKDFETLLNNETALKAYATRLRDQLTGDVLAGLHSAATIAEDDSLSKTGALQDCRWEFFATEPSAGNNPRSTTSSFPGILVTLEYENITYKGALLSEVDSNLQPRTGVTALPLLLTKFPNALRQTFITFLTSNFDTYVSNLRLSSTFLCAGLEGFVAGLEGVVVEDVIKELQLTLAFSPSVAPALRNVNVGIPRGSLVGFLREEKGTLKGKGKSIQRKNRVPLIANLTAYLETHLAMNVDLDGSRQDKVARQHVRLSKVACAAFVLGSEGRMKLVVDDRRAGEGDEDEEQEAPSLRASETLLRAVIRRAMIGDQVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q5</accession>
    <name>A0A1Q5T4Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4Q5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38661" checksum="0EDBE568E6C582C0" modified="2017-04-12" version="1">MPPLIPYHVSAGSNPVVKFGGALVTEFLEPPPGRCFCFRQRYCVKPTIDESDPDYERISAALHHPSGPPVHFHPFQNEYFRVEQGRMCVEIDGVLQILTPEDGEIMGRAGSIHRFYIAPDSTQDMVIILSASDPGLDYQLDRVFFENWYGLWHDYLVYEGKMDLIQLLCTYDAGDAYLLPPAWLPNRLRKFIGYWGGVIVGRWIGGLLGYKPFFKEYTTDWECAVKKMESSFFTRRLLGHSFSAAMTWTELQERALPWLTGGGTDRFVAPTLKANNKNDDMLERQDLFLRLQLDKASNTPLGKPVRKATDRDSPVVAKPQTTCIHDRKRGFSDIQDKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6U0</accession>
    <name>A0A1Q5T6U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannan polymerase II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6U0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6U0"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO95949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="411" mass="47123" checksum="46A946D04397C4C4" modified="2017-04-12" version="1">MLLPKGGVNWKSARAGLPPWRAILVLLTRTRFLVSVAVTGLVILLWRGVSRSASEMQNFYCYGSSKSPMEMTINEMVEWNAHAQTPVLFNHHEPYEVNSTSISEIDLNPIKSTTQAFHNHERVLILTPLRDASPYLANYFDLLYKLTYPHDLIDLAFLVGDSKDDTLANLASELDRIQNHADEKVRFRSATVIKKDFGAETEMTVEERHSFAAQGPRRKAIGRARNYLLYSALKADHSWVYWRDVDITDCPERILEDFMAHDKDILVPNIWFHRYRDGHDVEGRFDYNSWIESDKGRRLRETLDPDTILAEGYKEYDTGRTYLVSMGDWRKNKDEEVELDGIGGVNILVKADVHRSGINFPAYAFENQAETEGFAKMAKRAGYQVVGLPNYVVWHIDTDEKPGNLGDRKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T863</accession>
    <name>A0A1Q5T863_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T863"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T863"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO96422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="21006" checksum="7EC924F029055AD2" modified="2017-04-12" version="1">MQEDEPSLNIPSLLTLAVVSFFVLRWFFNRDEGSSAGGRPRGRGNVVDPAQVEQISQMFPQLSTRDIMWDLQRNGGSVAATTERILTGRGLETPPPSFQPQIVLPSANAQPTQATRAASASKGGGQDLISRYNLSGKIAADSNTEQPPTPASTSAWSQNKEERQRLLQKRRDEMILAARRKMVQKDQGNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8C5</accession>
    <name>A0A1Q5T8C5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8C5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8C5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="443" mass="52598" checksum="8E09DDA808EDC2FF" modified="2017-04-12" version="1">MSSRYDDYRSSTGTVESRDRYDRRNSRGPPVLDRPRQVDDERFEFRLREEDRYGPPARAAGRYYEDDHLSHPSGPLVAHDRRRRRDESPSFAPPRLIRRQSSLDTFDRIPRRKMESLESHDRPRGMPRVPHPPPPPRASPGRYREREVYEDIRIAEPDYYGDEEYREFRERNSMDHHHHRRRSSSTARSRSRREEKPYPRKGKTRIPRKWVHVHAILDLGYPFKEEDDVIVIQKALSKDQIDEVISLSKEFRRPAEHVETDYLRIPRSPVRSIPRERVTTEHLVVDSRAPRHDTYLLEASPRRHGDYEEIDYDEYIHTSRRGGITRPRSVSVNTHGRHSSPLRLIEPRGHVEERIEARPRNSGQLVLVRPRSSHHEVDDYVRDLEEEARLLRLERQGGYEVTRDRETDVIDSRGNEAEIHEVRRTERREPSSGVMRAMLATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8M6</accession>
    <name>A0A1Q5T8M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8M6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8M6"/>
    <dbReference type="OrthoDB" id="5420214at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="34809" checksum="FF6BA6F1CEA90F3B" modified="2017-04-12" version="1">MRPPEMSYSPAYHQGQDPLGAAARNSIIAPLPDRSLGPPDSSYPAAWRPSVDGTPYEGSPRSSGPRRSLAQSPEASRRSSRVDNESPVTRVVVSGGVIHKEEHSRGSWADQPSLMSADHSGTPRTQKRGGPVDIPAVDSQDALLMIFRLSVPVPMYSFGACLYTFFALIFALLISPLRLCPPTPYLRNTSFKSQLCDLLSPALHIHERLVRMRPPSSHRSSSTQWIHSEIDSDHPSALAETNRYYTIGMSILVLTLSPFFSIAILLFAWTAAFFWVFTMVMGNPDGTERKDDGRAAVLGVCKWWQTWLGKARKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8U6</accession>
    <name>A0A1Q5T8U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8U6"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO96662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="59488" checksum="711916795FBBAD7D" modified="2017-04-12" version="1">MESKSATDHVEEMDLDQMIRDARLATEKEHGMSLWQGLKLYPKAVGWSLLISTAIIMEGYDVVLMGSFYGFPAFNQKYGKLMKDGSYGLSASWQAGLANAMNCGQILGLFANGIVSERFGYRKTMMVSLVATVAFIFVLFFAHNVQTLLVGEILMGIPLGVYQTLTVTYASEVCPVALRAYLTTYVNLCWVIGQLIASGVLKGLSDRTDQWAYRIPFAVQWVWPIPIFIGVYLAPESPWWLVRKGKLAEAKESLRRLTSRGDSSFDADETVAMMVHTNEIEKENSSGTTYWDCFRGTDLRRTEVACLIWAAQNFCGAGLMGYSTVFYQRAGLAVSQSFNMSLGQYAIGICGTVFSWVLMSYVGRRALYVNGLAILCVLLFVIGFISIPKASTATSWATGSMLLVYTFFYDSSVGPVCYSLVSEIPNTRLRIKTVVLARNLYNCLSILNGVIIPYMLNVDAWNWKGKAGFFWGGFCLLCVVWAFFRLPEPRGRTFAELDILFEKKVPARKFKSTELNLFAEEPAIVNQEVTKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T905</accession>
    <name>A0A1Q5T905_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing factor spf30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T905"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T905"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18115">
        <property type="entry name" value="Tudor_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="31916" checksum="F5EEAE79796C5B27" modified="2017-04-12" version="1">MSDVAALEAEVKEFKIQLETVQSSLQVEPDNTELQSLKTELEELITLTETAIAELKPSAPAAKPKPTPASSKETWSSKDSVSRPSQPAVDRTDEVAATAPTPAASFSVNDTVLARWVSGDNAFYPARITSITGSSSNPVYLVSFKSYATVENLTAKDIRPIAGNDSRKRKADGTPGSSASPSPAPPSLSHANVISAAADINPTLANQARQEPGKVGDASARPAKVPRKVKANKELEEGKNKWQNFAAKGKGKFGKKDSMFRTGESVNARVGFTGSGQQMRRDPTRTRHVYQQAEDEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9C6</accession>
    <name>A0A1Q5T9C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/mitotic-specific cyclin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9C6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9C6"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="354"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="447"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="451"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="588" mass="66353" checksum="1CB9C2E338E7387B" modified="2017-04-12" version="1">MDAKPQRIRVRGDENVPPSFHANKAVHQRNKSTPALSLMAQNAKNGSVNTRRTFGGDLSNAKLIADDSALPGKPAMHVTDKKPALAQPAQRPVSMSGVKGLLNNVASKPVNPAGKANTTAPTNNIKRTNVVFRDQLEPVVEKEPSKEVITTQPARHTERPHGKQTAPSHVEKDDEDEEQEYFDIPSEDSASEPQTSEVNRPEREMLPTKAEIVKAAPAAANMGKPRARSERPRRNSYDDSSDYPAGSEVEYSEDEETRVYRFRGETTTGSTTTMIYPRATAAMEREIMQAQSIVEANQTEEEIEEDFYDPSMVAEYSTEIFEYLREKELAMLPTADYMANQAEIQWSMRSVLMDWMVQVHFRFALLPETLFLCVNLIDRFLSHKIVSLGKLQLVGATAIYIAAKYEEIEAPSVAEIYYMVDGGYTVDEILKAERFMLNILNYDLGWPGPLSFLRRISKADDYDLETRTVAKYFLELTIMDERFVATPPSFSSAGAHCLALLMLRKGCWTMAHAYYSGYLYTQLVPVMSTMLECCEDPQRHHMAIYEKYSDRRFKSASTFVEKEIKGGFQLPRPTPFHDTDRLDGVANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAZ1</accession>
    <name>A0A1Q5TAZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="631" mass="68666" checksum="B0DFDEAD6CE4290C" modified="2017-04-12" version="1">MSEMVGVAGPAAPPGNGRVSNGGSRIPQAAPAPIPAASSQAPSGVRTPTDIMRQRRDREARRKAEQEAREREQEELERQQLELEQLEQAQAQMYAAGAGADPASQRRAQPQRAPRGPQPQVPQENVAVTASGPAPGYRPTTSAGPTAPRQDYQAPPAAAGGHDMSSQPQLPASSSQQRLGPAAQHTRSQSAAAATGAQPGPSTFSKSAPAPAGSQPGGTSQTLQQPRRSGFPHAFERWETLSSHWEGLTSYWIRKLEQHNEDLEKDPLSQQLARQITDLSAAGANLFHAVVELQRLRASSERKFQRWFFDTRAEQERSKEVQADLERQLKAERQGRADAFAAAQTAEQDKTRAEDLLHEMRRELQISKEEARRAWEELGRREQEERDRTNSLRNGEPTLVGGVQVVPMVQGVPSRHTTRPPTREGPYPGGPTAASMGTDYRGKPTDPSMSRTYYDENTPMSPTGSDPFIEPKKTDPPASKAPYPPTSQLYPQEPTTASYPAPSSEPDAHSYVGSSEAEEEYAGYARDNAHPFSYPAAPLSEGSDEYDHHPADQHHYTTDGAYTSAGTSAPMHAPYPPTTADYSGAGWGVGTGWESVTPRHRHPTRLSDVLEEDEPSRTTPSRASQASRSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBG3</accession>
    <name>A0A1Q5TBG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000694">
        <property type="protein sequence ID" value="OKO97579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBG3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8889" checksum="D49E8BAC5C44D71A" modified="2017-04-12" version="1">MLIELLVHAPGAPCVSAATCFRYTVSATPSTRQWETVFNGRGIDWVFVVLDGIHEECISVRSALIGWRCVLCRRRIPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC98</accession>
    <name>A0A1Q5TC98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine decarboxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="580" mass="64121" checksum="C6A55E57702AB2C1" modified="2017-04-12" version="1">MTVTSEDHPLDTFLGHKLLEQHHIRDADEQLVRRPTTEEMARLEEMAIPGTPQDLEKVIAHTREILSYRIALGHTRFFSCIPSPASPVSWFGEALTNAFNPFAGNLSAGPGICAIERALVKWIANQFALPPTAGGQFVSGASIANMTAMTVARDHKLAEHTRSQGVVYISEQAHFCVRKALRIIGFSDRQIQSIPVDSNFRMDVRILQQAITSDLDEGLRPFLIVATFGTTNTGTIDPLLPIIDIAKSHNLWFHVDAAYGGAVAFSTKHRYKIEGLGQVDSIAWDAHKWMFQTHGCGLVLFRDGTHPLKSFAAGGEYVRDVSVVRDPSNYGIELTRPARHMKLWFTLQVLGTEAIENMINWGIELAMHAEDKLRSLDHWEITSPASLAILTFRYAPPHLDEIMFDRLNETISKEMIARNVAVMFTTILDGKVCLRMCTINPNTTMNEVTYVIQVVEDVAASCLQQSAHYCFIFENGGSGTIKQSLDAIAYGGIIAVIGFLSVTSREEMLDVGILALSKGANVRGVIIGSNEILEDVVRFISSHNLALPVERTSKFTRDGVIDAFDDMASGQHIGKVCINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCI4</accession>
    <name>A0A1Q5TCI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_9854</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="345"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO97928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="570" mass="63964" checksum="FB466B39603D83F2" modified="2017-04-12" version="1">MADNTAGGEGAGGKRKNRNMGRSEWSRQALDKRKRAEEREAAKRRKIENGEQVTNPIYATEFSKEEIDNEERRPKKKVAVMIGYSGTGYYGMQLIEDKPTIEGELFSALVAAGAISKANATDPKKSSFIRCARTDKGVHAAGNVVSLKMIIEDPDIVEKINQHLSPQIRVWGLEQTAKSFSCYQMCDSRVYEYLLPSHCLLPPHPSTYMGRKIVELAEKAGDLDDVNARQEDVTGYWEKVDEEYIKPILDNVPEDIRNIVQQSLSSSDVTPEDLDKEDQPVAEPVEEPKQSEESSAEQSKEDQPFVMDPRQRLILDTTKAVKAAYIKARRAYRAPASRIARLQGALDRYVGTPNFHNYTIQKTFKDPSAKRHIKSFNVNTTPVVINGTEWLSLKVHGQSFMMHQIRKMVAMASLVVRCGCHPDRIKESYGPDRIAIPKAPGLGLLLERPIFDSYNAKASSLGRGPVHFERFTKEMDEFKQREIYDRIFREEEQTSAFGNFFNHIDHFQNNFFLYCTSGGIPAAKLVSAPTEKGTFKGEGNKADKDQSAALAEVESSEDEGNLPEGGEKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCR8</accession>
    <name>A0A1Q5TCR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription activator AMTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCR8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCR8"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF24">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59281" checksum="44C996D9A138DD8A" modified="2017-04-12" version="1">MYPHAKRRRLTGDVSFPTDLENAPPPPPLSSPPGFTPTLNNDWTHTQTHTHPQRHAPAPAYTPSDSTDGPAFPSPLGAASWGHDGFSHDPGFLASQEELRCMLFTIAQSAAPTRAASPDANGLDEGRREGRSERNIGPMRSALSSRRRVEYLKNYVGQVAPWLDMFDSQCTFRVQIPALARTFPALLNAILAISARQMERKEGIQDSFDSIELYQEAIRLLSPLLQMRDPKVIAACVLLCCLEMMSARAQDWRRHLEGCTALFDAFGIHGFSSGLLQAVFWCYVRMDLCGALISDGTESTLLRPRKWLAPDCHEEDAAQLFQATQSPDMHANYAVYLCAKACELVADRTQFLELGAQNECTGDVFQRRWIRLWDDLQQWVEDRPPELLPVQTTQTKPFPHILFLHWAAISSNQLYHTACILLLNIMPKSIKLRSAPIVSALWHARRICGISLANPHQGCLNNAIQPLWIAGRLFSHVSEHAIIIDIIRKIEAETGWGACWRIRDLELAWGYPLTRRSRKSATQHSPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDE3</accession>
    <name>A0A1Q5TDE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDE3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDE3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20957" checksum="B4DDD93B4725C310" modified="2017-04-12" version="1">MTPEHNTYWKNVLIIVPIVGAGTATVVYLLRLYSRRLAAVGLLLEDLLMGIGLIISYCATAFVVQTSSAKESIWTCLELDVAIICGSLPLLKPLVQGFLGKVRSGVSRDRSHPSTTTKLNSSRTNNDGFQKISDRHGMWSGPKNATTAATISRQSSDVELNPIPSHTRVRREMDGPSDVSSAESVLGHEWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDS7</accession>
    <name>A0A1Q5TDS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDS7"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="40"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="450" mass="48650" checksum="728E5566C711C4F1" modified="2017-04-12" version="1">MFGRQVSSAARAAGRTAHAMPSIRKFATASPVAATGRAHKVVVVGGGSAGMAISHQLLQSGKFAQDEIAIVDPSEWHHYQPGWTLVGGGLKTKEELRRPLKDLADPKLKLYAESVATFSPEKNFVTLGNGDNLSYEQLIVAPGLALNWGAIKGLPEALADPTAPVSSIYGYDSVSKVFGTIKKLEKGNAIFTQPAGVIKCAGAPQKIMWLALDHWKRAGLYDPADPASSPIKINFATGLPVMFGVPKYNKALTALQQERGVNGLFQHDLVAIDGNKATFARPDGQEQVTQKFDLLHVAPKMGAPAFVKNSALANEAGFVDVDDNTTRHKKFANVWSAGDASSLPTSKTAAAVTSQSPVVVRNLLQAMEGKEPDALYDGYTSCPLLTEYGKVLLAEFKYGGEPKETFGDWFGIDQAKPRRSFYYLKKDFFPWVYYNAMVKGNWAGPKGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEC6</accession>
    <name>A0A1Q5TEC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="5">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEC6"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="309" mass="33413" checksum="41341F0977CC76CC" modified="2017-04-12" version="1">MTQSNTSAFDRANEAVTFLRSRLPEGLQSPKVAIVCGSGLGGLADTVHAEGRAEYDYASIPHFPRPTVAGHAGKLVFGLLGQKIPAVLMVGRAHYYEGHSMDQVTFPIRVFKQLGVDTVVLTNAAGGLNSDYCHIFLAGLAGVHPLRGPNEEEFGVRFPPLSDAYDLDLRRQVHQAWKQVIPAQSTRKLHEGVYAFVGGPTYETRAESRMLRMLGADVVGMSTVPEIVVARHCGLRVLAFSLVTNNAVLAPVPRGDEQLLQGKDAGELNAIIEEGKAGHEEVLEAGRNAALDMQSRARLRRSIDGDVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEJ8</accession>
    <name>A0A1Q5TEJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEJ8"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011831755" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="371"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="526" mass="56474" checksum="ABEB46F26266B76D" modified="2017-04-12" version="1">MKLSLLSLATLVTAAVADLDPIVIKGSKFFYSSNNTQFYLRGVAYQQDTSDSTSYKDPLADATACKRDIPILQELRTNVIRTYSINASADHSECMKLLSDAGIYLISDLSDPTQSIDRSDPNWLTSLYSRYTSVIDELSQYNNTIGFFAGNEVANTVDTTDSAAFVKAAVRDMKTYIKEKGYRSMGVGYATADVSSIRVDLANYFDCAEADESVDFWGYNIYSWCGNSTYADSGYKDRTEQFRNYTVPVFFAEYGCNEVTPRTFTEVKALYGDTMAEVWSGGIVYMYFQETNNYGLVSVVDTTSVSTMPDFKYYSSEIASVNPTGTNKASYTPTNTALQSCPTVGSGWQAKSSPMPPTPDSNLCECIYEESACVASSSLGTTKLASLLSTVCGYTDCGGVSANATTGEYGAYSMCEIRYKLAFALNKYYKEQDKDSSACDFSSSASTKATTAATGTCSAQIKEAGTAGTGTVTTEATATAGSSSSSSTSSSAGAPVTLHFSVTVGYFQVGVYAATALFAGLGMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TET0</accession>
    <name>A0A1Q5TET0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Axial budding pattern protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TET0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TET0"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012818519" evidence="3">
        <location>
            <begin position="18"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="131"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="939" mass="101623" checksum="82D2F8BAB1BD56D8" modified="2017-04-12" version="1">MALFLVITLALAAVVHAAALAANYPVNSQLPPVARVSQPFRFVFAASTFSNTDSDTKYSLKNAPSWLEVDSASRTLSGTPDSTDSGSKSFKLVASNGSDSASMDVTLIVTSDQGPTVGTSLVSQLQTVGPVSYPATLYIHPGQPFSIEFDPSTFHNTHPSTIYYGTSPNNAPLPSWIGFDPSLLKFAGNTPAFPGSGSQEFTFQLVASDVAGFSAVNQTFQLSIGPHILAFNETVQTFNLTRGETFNSPSFESFVTMDSSPISSKSLTSVDAELPDWLSLDKNSISLIGTPPKDAVNKNVTITVTDTYYDEAKLMVRLEFLELFLETVKGCEATIGEDFSYVFNQSILTDDSVQLDVDLGDDLPWLSYNPANKILSGHVPSDAQPQTFTIHLKASQGSTENRRDFELDLLEPSETHSGGSGSSDPSSPSHQKAGIIAISVIIPLAVILSSIILFCCWRRRRKSTTVEDGQEPPEAKVPPPRPARPDLPNCQPGATGRPSQDDNSDDWMSPISPASDLPKLELGPTWNVASFDKPEDSMMAIPEPSPPPRSPKRAFVPLRDSGIEDKPVNKSPTRKQNQRLSFSASPGVRRRTSNRSRREPLKSIQPRAMKRESIQSSRSKRYSKRSSGISTVASGLPVRMSGAGHGAGGFGPPGHGFVRMSWQNTKASFMSDDSIGNITPLFPRPPPAAARARHSIAESIPENTKRVTLRAVEPDESTISEADSLEAFVHSRAKHRNSSNPLFSAQISRRTSSGLRALERARSLRSRADTVSVSTFSDEYRQSIQGRPYSTAMSVSEYGDENRVSQYQPLQPPPGLFPLTEGGGKSQSQLSLAQDYRGVISPLPRFWSENSLSSARRLESGSHPKPPQQLRADIDSGIPQSSSIVSDLEEHLSRKASPQKAAAARENQHWNMGLEPPPPLRSASSRGLPVASSGEIAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEU1</accession>
    <name>A0A1Q5TEU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="24902" checksum="FEFA92DD0D5510F2" modified="2017-04-12" version="1">MRVKKSTEPPDSEGASDQKQDPLERRRLQNRLSQRNHRRKIRDRIAKLQERVIANELRAAAALNGWDQPYTPPPLLGSRNLFQQDSGPGNGGADTSSSMTEPFLSFSSSYGLSMTSPWPIAAAQSSTLLSEDSTWLWNIGSSPMDTTYSNLTLCDLMSDATNPSSLGSGEEQPIPDLSSTWSPPHSSASFATPVNQPLYYAVNDGCCAKQDVSMPISKHGTWVAGIDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF77</accession>
    <name>A0A1Q5TF77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_8796</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF77"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="21">
        <location>
            <begin position="12"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="20">
        <location>
            <begin position="155"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKO98879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="370" mass="38500" checksum="6AC72C053CF1385B" modified="2017-04-12" version="1">MSASPIYLGVVGVGGVGTAFLSQLAHLPNAPKLVLLARSSQTLLAPTPAYSPAIPAADWATAAAGPSLTKTGALPAEEIASYLASAPGRAILVDNTSDINLARQYPTFLKKGISIVTPNKKGFSDDLSLWKDIFASAAEGKALVYHESTVGAGLPVLSTLKDLVATGDEVTRIEGVFSGTLSFLFNTFAPASGSSDAKWSTVVAQAKELGYTEPDPRDDLNGMDVARKLTILARLAGLEVSSPDSFPIESLIPAELASLPSSADGIAEFMKRLPDFDAQMANIKDTAEKEGKVVRYVGSIDVAAKAVKVGLQTFEKDTAIAGLKGSDNIISFYTKRYGANPLIVQGAGAGGDVTAMGVSADLIKVVQRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFE7</accession>
    <name>A0A1Q5TFE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Spindle pole body component alp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFE7"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="262"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="564"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="849"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="975"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113078" checksum="7BA6936D6BD55ACE" modified="2017-04-12" version="1">MSTSTRPTTRPRRIDDALSQLVDSLLPEIPLSALPQDHDFSDDDLAIAAAEEHRHHALLERAWRTLESHPSNGADPSSPAGRRGSFAAEDVNHAPDLIKRKLRRENASPEKIVRFSNLYTRLLTQPVLSQKWGILYLLYKLGETEEEQAVERSRSPLMDEGNLQNMLGRGAGRPRRGTFVESEDDEGPAVSSSASQPPRISRESRPQRPSSLRRDWEESTERATASRASHYETGDEHDDVASATETPGNHPRSAASVENGLLRDLPFNLQGLSSTNLQFQSPSVLKLPSNLPAPIISLLNALAEPCLLYKELAGFVESAEGGLVNQSLRAAVANELRSYLGLVATLEAEIRQALAAVGDASSMQGVRKGGVTLKRCMVWTRDATMALRLMSLIVEEARDKKGGQLISLIHGFSSSHGDPFVCSFAEKLLAHVTRPFYDMLRLWIYDGELSDPYKEFFVAESDLRTTTDPRRTATSVWEDKYKLDDDMVPSIITQDFAKKVFLIGKSLNFIRYGCGDSGWVEAYSKEASKELRYGDTATLETSIDEAYKTTMARLIYLMDDKFKLFDHLRALKKYLLLGQGDFIALLMESLASNLDRPANSQYRHTLTAQLEHAIRASNAQYDSPDVLRRLDARMLELSHGEIGWDCFTLEYKIDAPVDVVITPWGSTQYLKVFNFLWRVKRVEFALNSTWRRCMTGARGVLRSVDDKVGPDWKRARCVIAEMIHFVCQLQYYILFEVIESSWDQLQAEVSKPGCTLDDLIEAHTKYLNSITHKGLLGSATTSRYGVSTSASAKQPEESFLSQLHHILKIMLSYKDAVDGLYSFSVAEFTRRQELSAKIETRTAQGRWGVTDRDVLPRRANSRGGASMASTPDIRPASTGPDGIDTPFSLSAQDLAADDNMLASLRIRLRDLSADFRTRLTTLLSDLSYQPDVDMRFLAVVMNFNDVYKPSRRRPKPTSGVRDRDRERERAKRKAAASAATANAGTGSGTESSREMRRERSAAGGSEPGNGNGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THX0</accession>
    <name>A0A1Q5THX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8035</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013338891" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO99818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="256" mass="28696" checksum="247932E2D770A6F7" modified="2017-04-12" version="1">MKSILLLSALCARASAFSIPDGHPLVHWRPAGPGDANHGLLPHDGKNITEEQTANALKLSINLNEDVAKSQFQEALATNPTPGATTFSLDDLSRHNIIEHDASLSRQDHYFGDDQNFNPVIFDQTRSHWKGLFINVHEAALARKARVETSNATNPEFTLSKSALTLTYGESAVYIVTFGDRSAGTVRKSWVEYFFEFERLPTELGWTKHEDEITSSDLNSMAQRVIDATESSDEEKHSLLRRRDFHAGHTARRHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI69</accession>
    <name>A0A1Q5TI69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI69"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI69"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="31001" checksum="1FCE83581E8CDB5B" modified="2017-04-12" version="1">MALESEGLYHATLAIAANTLQLSDSRYRLPALEHHHRALSHLRELLSHDTWGEKELDEMLGLVLMLCWFDVTELAWSKEDDQNDIHPSAVYRLKRNLEDIQQRLPNGQIDPTTECAAIAEANRLGALLLLHETCSPKAASTSRSGLPAFDTEEKSRFVGQILNLILEKKANMMRTAVLPLWPLFLAGCCAREDEERVTVLRLFEELNGIRRFGNIAPAKEVVEMVWRQRDLAAEDEGKRQRGEAQPKKDPLQGARFAWEHAMVMLGDWKLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI84</accession>
    <name>A0A1Q5TI84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_8149</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI84"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI84"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="169"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKO99932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="43022" checksum="1EEFA49123840298" modified="2017-04-12" version="1">MDTTTEPSNAVAELENTQPPTETGDQALQPVKKTKKIIRRRKKPARVQVDPSTVKSEPPAQTGELWNIWYSKWSGGDSQDKHGLDQPAPSRCNVANDSGYTKADQVPGSYFCLYFSKGQCWKGPACEYLHRIPTIHDHFNPSVDAFGRDKHQDYRDDMSGIGAFTRVNRTLYVGRIHVTDDIEEVVARHFAEWGQIERIRVLTGKGVAFVTYSNEANAQFAMQAMSHQSLDHDEILNVRWATVDPNPLSQKREARRLEEQAAEAVRRALPAAFVAEIEGRNPEAKKRKKIEGTFGLEGYDVPDDVWHARTRQLEDVPATGQLEAPEQSLMLEAGSTGAEVQQEPDAQAGIFSSSTLAALRGMAGSNVTTQAAPKSSGGPLVAYGSDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJC2</accession>
    <name>A0A1Q5TJC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TJC2"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="540"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="689"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="837"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="983"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1427"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1678" mass="190478" checksum="4E89E73E3C1AEF81" modified="2017-04-12" version="1">MAPLPIKFTELINLTNVGIAQPSIGFASCTLESDHYVCVRQKLEEDDKPQVIIVDLKNNNEVMRRPINADSAIMHWSKNIIALKAQGRTIQIFDLSVKQKLKSAVMNEDIVYWKWFSDKALGLVTETSVYHWDVYDATQQNPVKMFDRLPNLAGCQIINYRVNAEEKWMVVVGISQQQGRVVGSMQLYSKERGISQFIEGHAAAFADINVEGSPLPHHLFTFAVRTPTGAKLQIAEIDHQEPNPRFQKKAVEVYFPQEAVNDFPVAMQVSSKYDIVYLVTKYGFIHLYDLESGTCIFMNRISSETIFTTASDTDGAGLVGVNRKGQVLSVSVDENTVIDYLMNNPAMSSLAVKLASRAGLPGADHLYQQQFDTLINAGNFSEAAKVAANSPRGFLRTPETINRFKNAPQTGQMSVILQYFGMLLDKGSLNRYESVELVRPVLQQNRKHLLEKWMTEKKLEASEELGDIIRPYDMSLALNVYLESNVPHKVVAGFAETGQFDKILSYSKQVGYQPDYTQLLQHIVRVNPEKGAEFATQLANEEGGALVDLDRVVDVFLSQNMIQQATSFLLDALKDNKPEHGHLQTRLLEMNLVNAPQVADAILGNEIFTHYDRPRIAQLCEGAGLVQRALENSDDSALIKRNIVKTDKLSPEWLMNYFGRLSVEQTLECMDFMLEANIRQNLQAVVQIATKFSDLLGPNRLIDLFEKYRTAEGLYYYLGSIVNLSEDSEVHFKYIEAATTMGQLTEVERICRESQHYNPEKVKNFLKEAHLTEQLPLIIVCDRFNFIHDLVLYLYQNQQFKSIEVYVQRVNPSRAPAVVGGLLDVDCDEAIIKNLLATVDPAVIPIDELVSEVESRNRLKLLLPFLEATLATGNQQQAVYNALAKIYIDSNNNPEKFLKENDLYDTLIVGKYCEKRDPNLAYIAYSKGQNDLELISITNENSMYRAQARYLVECADPEIWAFVLSENNLHRRSLVDQVIATAVPESTEPDKVSVAVKCFLDADLPGELIELLEKIILEPSPFSDNTSLQNLLMLTAAKADKGRLMDYIHQLNEFSADEIAEMCISVGLYEEALEIYKKVNNQLAAVNVLVENIVSIDRAQEFAERVELPEVWSKVAKAQLDGLRVSDSIESYIRANDPSNYNEVIETATHAGKDEDLVKFLRMARKTLREPAIDTSLAFCFARLDQLAELEDFLRSTNVADIEASGDKAYEEGYHQAAKIFFTSVSNWAKLATTLVHLEEYQAAVECARKANSVKVWKQVNQACVDKKEFRLAQICGLNLIVHAEELQALVRQYERNGYFDELISVLEDGLGLERAHMGMFTELGIALSKYHPDRVMEHLKLFWSRINIPKMIRACEEANLWPELVFLYCHYDEYDNAALAMMERAADAWEHHSFKDIVVKVANLEIYYRALSFYLQEQPLLITDLLQALTPRIDVSRVVRLFKTSDNIPMIKPFMLNVQSQNKRAVNDAINEILIEEEDHKTLRDSVDNHDNFDNVELAQRLEKHELIFFRQTAASIYRNNKRWEKSIALSKQDKLYKDAIETAAISAKSEVVEDLLRYFVDIGSRECYVGMLYACYDLIRPDVIMEISWRKGLHDFTMPYMINFLCEQTRTIEMLKKDNEERKSREKSQQTEEDNTPILGGSRLMLTQGPAAPGSPMPYGQPANGIAPQATGYRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK41</accession>
    <name>A0A1Q5TK41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TK41"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010312328" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="3">
        <location>
            <begin position="283"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="527" mass="57081" checksum="49A92231B780AB44" modified="2017-04-12" version="1">MSSRQALGQAAFFVVSFAPFLVSASPAPTAFVNNNDVSPPFPAITPSPVEKNPSPVVQRDILSDVESDVNNVLSSLGSDLPSWVASGVPNYFQNFPTGDAVASSLGLKSSDLAALPTNVLNIDPYANWTNSGWNVRFHGNVYKQPNTSVADLNKLANVFLIDTKIADLPESQQEQARNLTAEIFVVQQPHVAVNTIHLEPAASQGSSGQPGGGGSSHTTGGWQNVTLPYNTTAEGDFDVFVPIASNGLTAGNKTSAIQRLNTHVDGASIGNATAYLVPPTGLTVVSDIDDILRITKIYEPKEGLFNSFAKAFTPWENMPLIYSNWSSSLPNMHFHYLTTTPEQVTRNYMQFIYSTYPGGSFDTRPLNFSDVSATLSIRKFLLQKIFETFPQRKFILIADTSNSDVMRDYPEMATEFPGQVQCIFLRNTSATDSGDKFPYDTSGFKNLPQSQYMFFLNPDDLSNLDIANGECYNKSIPQNLTFSYQGLPFGLGKHSGAGGGLSTREVVGASSLMALVASMLTAAFMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKG3</accession>
    <name>A0A1Q5TKG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_7646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TKG3"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF7">
        <property type="entry name" value="ALPHA-1,3-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293405" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2010"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2044"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2068"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2185"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2226"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2257"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2290"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2335"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2362"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2408"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="67"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1642"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1653"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1704"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1733"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1773"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1802"/>
            <end position="1814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP00715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2436" mass="272649" checksum="535201FF5CF47705" modified="2017-04-12" version="1">MRWLLSSGLLALFATTSTCWPYDESLLQYNLNQNKTATNPAHYWGEWPDHKGKYHPSPDNWRFPFYTLFLDRFVNGDPTNDNINGTLFEHDLDSTQMRHGGDVAGLVDTLDYLQGMGIKGLYLAGTSLINQPWGFDGYSALDTTLLDQHYGTLQVWRDAITEIHKRGMYVLFDNTIATMGDLIGFDGYLNTTTPFSEKEHQTTWKTERRYVDFDIGNTYNETCDYPRFWFEDGYPVNESQTAQLVGCYDSDFDQYGDIEAFGVFPDWQRQLAKFASVQDRLREWEPSVRERLIRHSCMIIASLDIDGFRYDKATQATVDALGEMSLAYRECARAVGKDNFFIAGEITGGNTFGSIYLGRGRQPNQYPNTTTEAMAMTNESDSQWFLREVGHEAIDGAAFHYSTYRALTRFLGMDGQLSAGYDVPIDWVNAWNEMLTSNDLVNANTGKFDPRHMFGATNQDVFRWPAIQFGVERQLLGSFVTTILIPGIPLLLWGEEQAFYILDATASNYIYGRQAMSAATAWKTHGCFSLQSSQYYQWPIEAASQGCNFDNVTYDHRDPSHPVRNIMKHMYQLREQFPVLNDGYTLLNMSKQTWGVTYPGSNETVTETGMWSVLRNLNTEVQDFGSDAKNSPVWLVYQNLNSTKDYTFDCKSEDGALLSPFDTGTRVKNLFYPHDEIELVDGPKKLGLSGSKKWNGCYGNLTLKPYEFRAYVPIDLFQKPRPMITGFTPGHDHPLLSSVAPDQSEEVHIELEFSEAMDCDSVTNGLSMSSSTESGKSPTINTKTINCASIPAGETQWTGQIPSVWRWSANLTGVYNGVHRLTVNNVTSADRNSSTNAVDNFLFRIGQFDNPMVFTSANYSSSLLHQHDGNSTLFIQHHAAGADKYRYSTNWGTTFSDWQTYKGGNDTIDRLVWTGTKKQDWKGDHVRVEYWSRWTGSSSYVQEGDTNWVHTTQRRFPHAFFNGPYNQYGYDGGLDNEIQLDALDGYWKYHFTSEWPAVGQINIWGINPDGKPDQSWVLGDMDNDSVLDRMPPSSLSSTLINITEPPPAPYLSWRLQINDGTQRFHLLPVGHRSTQIVMFVLFWIIPALTGAACVYIFMMSFYKVKFNEVGVSEKSSLSPMVFLKKLAHGRSGDNSINSLMRIGNKAGFMQSTTALGAAGAADKRRMVLIATMEYDIEDWGIKIKIGGLGVMAQLMGKTLGHQDLIWVVPCVGGVDYPVDEEAEPMEVTILGSAFQVKVQYHRLNNITYVLLDAPVFRQQSKTEPYPARMDDLDSAVYYSAWNQCIALAIKRFPIDLYHINDYHGSVAPLYLLPETIPACLSLHNAEFQGLWPMRTQKERREVCQVFNLDEDVARKYVQFGEVFNLLHAGASYLRVNQQGFGAVGVSKKYGKRSYARYPIFWGLRKVGNLPNPDPSDVGEWTKQPVTEATVDPEYEAGRAELKRQAQEWAGLEQNPDADLLVFVGRWSMQKGVDLIADAMPAVLEARPNVQLICIGPVIDLYGKFAALKLSRCMEVYPGRVFSKPEFTALPPFIFSGAEFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYNVESTSTSHLLMQFKLAIDAALNSKTETRAMMRARSAKQRFPVAQWVEDLEILQSTAIAVHEKEVSKGHGRPVTSSGTSTPNGTFTPTGTFTPNGTLRSVNMGMTPMSPLPAPGMNAALQHSRDSSYSSFNQVSDLGSQRIYSRDISPSETELPKSGLSRSLSLGVRSGPGHRSRRGRNGQTEGDIPESGDSSDAVEETDDDEDRAHSVYGDDEYTLTPAQLEESRRAQAAHREGIVSYSSPLNSPRRRPSDESLHPRFLLPPTSPGTPPASDALLLPPRPLGESHRFSNASVLSLDSVVGGKKDFKLQKVDPFFTDGTGEYYHNFEQKLQSLNGSNSEGQLCIEEFLVKSEQEWFDRFRDAKLGRHKSPTPSIFRSKNNASPAGESYNDGLSHIALSDDHDSDDDEFLLGKDYVPPTGLKKWMQIKVGDWPVYSIFLALGQIIAANSYQITLLTGEVGETAEKLYGIATTYAVTSVCWWMVYRYFKSVVCLSTPWFFYGLAFLLIGSAHFEPNSFNRGWIQNIGSGCYAAASSSGSIFFASNFGDEGGAPVETWIFRACVIQGIQQAYVIALWYWGSTLSKASSEGLLTSDNTISNTWKMSAICYPIAILLWGIGLLLVFGLPNYYRQKPGKVPSFYKSLFRRKIVLWNFVAVILQNFFLSAPYGRNWSFLWSSTHAHAWQIVILCIVFFGAVWCVFLFIISRFSKKHSWFLPVFACGLGAPRFIQIWWALSGIGYYLPWVGGGMTGGALASRSLWLWLGVLDSIQGLGFGVILLQTLTRVHMCFALIASQVLGSIATICARAFGPNSVGPGPISPDMTKGAHELANAWFWVALFCQLLVCAGFLLFFRKEQLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM52</accession>
    <name>A0A1Q5TM52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM52"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="738" mass="79694" checksum="87EECB6E63AFF1AB" modified="2017-04-12" version="1">MDFLKSAVASAIAKGSSFPVSMGDRVDIGDSIWTLHNGTRREDGSACSVFTFDIAANKSRLPLAKNAVRKSRTLRHPGVIKVLDTIESTLKFINDDASSVHGAVRASSVYTSESGEWKLGGFDILSSMKEDDAIIYTYGSLVPDAARYTPPEVVKGGWDAIKRHPLAAVDAYGLGILIFEVFNGHFSGGDQVGKTTNIPPSMQQSYKRLCTANPKLRLSAAHFVEQGKKQGGFFQTPLIRLTEDMESLGLKDDAEREEFINELDNLSDDFPEDFFKMKVLPELLKSVEFGGGGPKVLSATLKIGSKLSADEFNAKLTPVIVRLFGNPDRALRVCLLDNLPLMIDNLPQKIVNDKIFPQMTSGFTDIAPVVREQTVKAVLSVVNKLSDRVVNGELLKFLARTANDEQPGIRTNTTICLGKIAKNLGPGTRSKVLIAAFTRSIRDPFVHARNAGLLALAATIDTFTEEDCAGKILPAICPALLDKEKLVRDQANKTLDLYLQRVRKFGGTMADTVIQPPTSSTPEPNKSDARIGNSNDKSWAGWAISSFTNKLAAADGEIAPTVTANKPSENIPRPASVPRPTTSSPSIQPEPTNKILRAAAHPLSRSQSDRPVPIVQDEWHDAEEGDDVFDAWGAIDEDDDKGVDPFTAAVTSPNPSSPEPTASKASAVPYDDGGEPDFAGWLAAKNQAKSKNPLPKGLTKSMPAAKAVAKPRVVAPAKKIDTKPKDADEDDGWGDAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM91</accession>
    <name>A0A1Q5TM91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM91"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013135458" description="GPI anchored serine-threonine rich protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="21414" checksum="D0821BD641A14440" modified="2017-04-12" version="1">MRFIATKLPLLLAASATIVVGQDPTTTGTGSVSTGSVSPGSSSKCAAQKVVDQCIQNMKFQLENCATYDWDCQCISSTNVVDCYNNCPEHPDRIGAQTIRQQNCANARAYSPSTTASSPSSTATDKDSDSSSMSASSSAYASGSTSTPSGLQSHNKSTDEESDSGSSSEPTKSLTGLEASSSPSAGAAVKGVRVAGGWVAFLGLALGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQG9</accession>
    <name>A0A1Q5TQG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQG9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11852" checksum="E73F06DEC66F789F" modified="2017-04-12" version="1">MPSSHHRVPNMQTRYVNIYFDPQDAYLSDIDLLGLIQDKISQGDVKITPWSIMRESRLCYSIKVTGEFHGSGDMCGLALNKVYLWIRYLSADGLPFFRRDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRR0</accession>
    <name>A0A1Q5TRR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oxysterol-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6985</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRR0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="222"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP02913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="973" mass="106393" checksum="ACB7C391FA656E3F" modified="2017-04-12" version="1">MAAMEELEIHSKVRSNRNAPSSNPIPSPRKLIQSSPPKQSYFVRWINVSANHTISWSIQPHKKSVNFGIFKHPGQSSLSSYLPASDSHSTDSTENLPATAANAGASRNQQSTVIEKLTAIGLKSIKWIGKCEADRISQGTYDVPASEAGNYALVFDNTFSKQISKTVTLVLLTYPTGLQPHGSAPPSIARSHAGGSSDSLPQPRTRRRGNSKSTLSAQVSDSSVHTGLLQKRRRKRHQGWARRFFSLDFTSSTLSYYHDPNSSALRGAIPLSLAAVATNEKSREISIDSGTEIWHLRASNDQDFSSWKRALEKASSKDSNPNELSVIGGAPQLRLTTPGHPSPAEEAKWAQVEKLVSQVSGSRDAVRRLARDTDPKYIVSPAPSPIEPRSRGRSPSPGPAAAQDASSSDPKRSFWKRKTSGNNSKRPPGPEQTNSSSSQLVVPKPDGTGRPASIASHADGMDEIHENLMAVLRDLDHAVSEFSALIAESKQRRHPPRSAIIPRKSMESDISQEFFDATDGGATSPLLTIQDSDGEDAEDAAENVEDDAPSDSEDETEATTPHDTSSASPLFPARPKSLTPLPLDKIRRRQNIAAPTVLPPSLIGFLRKNVGKDLSTISMPVSANEPLSLLQRAAEILEYSSLLDQAAQASDPVERLMYVTAFALSSLSSNRVRERSIRKPFNPMLGETYELIREDQGFRFIAEKVSHRPVQLAYQADSREWSLAQSPMPSQKFWGKSAEITTEGRVRITLHSTGERFSWTPATSFLRNIIAGEKYVEPVGELAVANESTGHRSISTFKAGGMFSGRSEEVTTRAVDSYNQPIALGLTGTWPASLTLTRDGSPSGKPIWTAGPLVPSAPKHYGLTAFAAALNEITSIEEGRLPETDSRLRPDQRALEEGDLDRAEEVKVQLEEGQRARRRDMEAAGENWTPRWFTRVSEDSDGEVVWRLKGGKDGYWDERARGSWSGVVPVFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT16</accession>
    <name>A0A1Q5TT16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT16"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9616" checksum="C9C937322967CFDE" modified="2017-04-12" version="1">MDTRGAAPRPSTVRDMANILLAARGESPPATVGKNWPSSFVQRRDELRSRFSKRYNYQRALNEDPKAINEWILMVQRAIEENGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT24</accession>
    <name>A0A1Q5TT24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_6871</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT24"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT24"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="37"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP03368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="370" mass="39775" checksum="78538BB67158D90F" modified="2017-04-12" version="1">MFRQSIRRFGTTALRTAAAESYTARVSTAQGVVNGLTEAIGNTPLIRLKRLSEETGCNVLGKAEFQNPGGSVKDRAALFVVEDAEKKGLLRPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPENYNHQARRHAESLDNAVWTNQFDNSANRQAHIETTGPEIWAQTAGKIDAFTCATGTGGTLAGITRYLKTASDGRVKSFLADPPGSVLHSYIQSGGKLIDRSGGSITEGIGQGRVTDNLQPDIDLLDGSLNIPDEKTIEMVYRCLDEEGLYLGASSALNVVAAKEVAEKLGKGSTVVTILCDGAYRYADRLFSNTWLESKNLRSSIPKHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT32</accession>
    <name>A0A1Q5TT32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Riboflavin transporter MCH5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT32"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT32"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP03378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="410" mass="44248" checksum="BD5905DA540C2797" modified="2017-04-12" version="1">MPSDEEKRQNPQEPPNGGARAWGVALGAFAAQMCTFGYINTFGVFQSYYSTTFLSSESSSSISWIGSLQAFLLFLFGAASGPLSDRLGVKAVVIPAGLTLVFSVMMTSLSHEYYQFILAQGILGGMACGMIFTPVVSCVGQYFTTRRAWAMGVVVSGAAIGGIVFPITLNRLLNHHHLSFGWSVRIIGFIMLVLLVYAALVTKEFAPRRQKNMFLISAFKQWPYNLTNAGFLLALLGLYAPIFYIADYAIERGGMSPQMALYQVAILNAPSFFGRTIPNLAGDKLGRFNITIFTYAACAILLFCWTAATSSAAIMVWIAFFGFFSGGAFSLYSPTVAQVCPNPSDIGTYVGQGLAICSFGALAGTPINGALIRSYGYLEASMFSGAMVTAGLLCQILARFLLEKRPWAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU68</accession>
    <name>A0A1Q5TU68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="4">
        <location>
            <begin position="255"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP03774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="503" mass="55279" checksum="F107B3D7F875D96E" modified="2017-04-12" version="1">MWGVKQFTTLSDRGRFLKTGDLARYNADGTINLLGRKDSEVKIRGQRVNLKEVEILMRPQLGPNFDIFVESVLPKGSTPTLAAFLFAKDAHSLSSKSVDGHGFAAHPTSLSARIQLVDSPLQTSLPVDMVPAVYLLVSALPTSISGKVDRRALTERVIALTGAELDTLMHGQPAEVLPPSTPMEKRLVTLIADTPQLECANIAVNASFLKLGGDSHRNGLYIFPAPTIASLAQRAQVQIDTKTIDFDRNSLFGLTPMQRHILSGERSPTGSSVLIELQRQQESCQVADAILSLVIQHPMLRSRFVVLENGEVRQMMMDAVDGGLLFGEREIKLSEDFETLRETGISLLDPCKGPVVGVYLIQSLGGKQMLLLVAHDLIVDSRSWVVLQSDLEQLLGENTLDEVPSFQEWYNLIQGKAKQNDILRELASEGWAGGDDDSNIPIYGSSLKLLRGQTAALDSEPCHLLFGDVRELLQVQPWQIILAALARSYYLVFPDRRPPSLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUF7</accession>
    <name>A0A1Q5TUF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUF7"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000219">
        <property type="entry name" value="tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="49"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP03833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="26016" checksum="E0F0A054F72FE722" modified="2017-04-12" version="1">MADQAEVYEEQNVHEVYQQIAGHFSATRYKPWPIVEKFLQGLTPGSVGLDVGCGNGKNLQVNRDVFIVASDRSENLAKIAVQHQPHSAVVADILHLPHRDAHFDFAVCIAVVHHMSTPARRIEAIAEILRTIRRGSDTQPGGRILIYAWALEQKNSRRGWDKGDSQDLMVPWVRRAKPGSGEEDQTFHRYYHLYESGELERDIEQAGGVVVESGYEKDNWWAIATHKHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0G0</accession>
    <name>A0A1Q5U0G0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0G0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="10078" checksum="8231C04269DBDFCA" modified="2017-04-12" version="1">MFYIFYIRPTADEVLPVGFTGNGVTAPDDAVTTNFIFYGTYLMWEYDDGSLSDSFRAKETNVTGVYELYYDFSNLYPSGYKTPVVKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1N5</accession>
    <name>A0A1Q5U1N5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_6334</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1N5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1N5"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP06344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="325" mass="33481" checksum="A87AD20B9A73F72C" modified="2017-04-12" version="1">MAFTPRGRGGPPRGGRGGAPRGGGGGRGGFGGGRGGGFGGGGFSGGGRGRGGGGRGGPPGRGGRGGPRGGRGGPRGGAAGARGGARVIIENHRHAGVFVARGGKEDLLVTKNLTPGEAVYGEKRISVESPAGDDGVVTKTEYRVWNPFRSKLAAGILGGLDNIYMKPGAKVLYIGGASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLVPMVDVIFADVAQPDQARIVGLNAHMFLKEGGGVLISIKASCIDSTAAAEVVFTREVQKMREEKIKPKEQLTLEPFERDHCIVGGIYSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2P8</accession>
    <name>A0A1Q5U2P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2P8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2P8"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="277" mass="30930" checksum="AECDB8C1D4AEDD97" modified="2017-04-12" version="1">MPCADCYRGHDHPGPVHGLEVKLFGHDVYVTEPQSKKSARKAIIVVLTDAFGWNTANLRRLADSYAERTSCKVYVPDFMYGTAAPASTKALVDRILSEDGLWGWLVKPWLILKAACVLIPFSIRNKPMKRYPGIRKFMDELRCTEGEDLRIGVVGFCWGGYGATQLAHGDLARNGKPLVDAAYTAHPSELKLPDDIEKIKLPYSMVIGDIDFALPLNGVHQVADILDSKKDVESEVVIISNARHGFAVRGRPDDQIEKEMADQAEDQMVKWFARYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4W1</accession>
    <name>A0A1Q5U4W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4W1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7366" checksum="6D4C58AAB5DD49B7" modified="2017-04-12" version="1">MQAPLREYCISPDEFVVANHVLDLVGEAEQRQAGWLWFGAALVGVTPITRISVRDVSHALQASWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5X5</accession>
    <name>A0A1Q5U5X5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal catalase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000576">
        <property type="protein sequence ID" value="OKP07885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5X5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5X5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="10895" checksum="2300AD46EB423879" modified="2017-04-12" version="1">MNGSFNYTKIHIKSRQRVKNLTHEETTRIAGEDPDYMIRDMYEAIERKEFPDSAGPFVRIPRCSSLPSWRQQLPTNVAKAPVYCYGGALRPFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U702</accession>
    <name>A0A1Q5U702_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity glucose transporter RGT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U702"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="43688" checksum="DC0E18F3FD7A56E9" modified="2017-04-12" version="1">MVSQKYGRRLCMFVMSCYALVTATITVTSQSREQILAARILNCETRRKIEFLYQDLTLTDVYIGFELSVVPVYQSEIVPAPVRGFIVGTYQLSINSPRWLLLQERVEEAEKSLKRLRYGTMTDDAIATELASLQVGLAIEPEKGAFKELFQGVNLKRTAIVIAISFFQQATGQAFASQYGAIFIKSLGTINTYNFTIITSCIGALVCLCSNFLNDKIGRRKLFIAGGIIQFAALLTMGGLGTANPVTRQESSAIASMVAIFGVGFGLGWGPLTYVVVTELPALSLRDHSQRVSFLTNIAVNFAVTFSIPYLLDDKYAGLHSKVGFIFGSIAVCACVFVYFCVPDCQGKSLEEVDRLFHEGVPVRKFRDYYLPPLDIVPTDKKELEKEHESMEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Y4</accession>
    <name>A0A1Q5U7Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7Y4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11204" checksum="12D5E49287BEDBF7" modified="2017-04-12" version="1">MFATNPSAGGLGAAELWAVKLWIRETADHVLQPSLYWKQKIAALLEIIAEVRAEIINSRHSEADGWERVKKNPARFRLRKEAPVKVFKYIPRAHNSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Z3</accession>
    <name>A0A1Q5U7Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Soluble epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7Z3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7Z3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="31457" checksum="8DB9F02695AF984F" modified="2017-04-12" version="1">MTSKWQVKRLLHGIRAIVGGQGPPVILIPGWPQTAEAFSDIFEPLSQQHQFFALDPPGLGDSPPSLNGYDTAYVSKIMAEAIHDILEEESKYHLIGHDVGGWIAYSWAAQFQSRIKSLSILDASVPGFLPKFEFPLSNQTNLRLWQFSFNALPELPEILTQGRERELLSWFFNLKTYADGFPGDKFERYIQAYSRPGAMSRGFEYYRAFEASAKQNLEFAKMPLDIPVLALGGAGSVGSGMIQLVQNFARNVSGGAIDECGHFLPEEQPAAVANRLLEFLEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U819</accession>
    <name>A0A1Q5U819_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U819"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="8087" checksum="B72F08920470CAE3" modified="2017-04-12" version="1">MFEKLKTNVYEMGDIDNGVYGYQTLFAEFDYSAGHFLYYSMMYYGGIGQVRIYGIHRDYDVHYGTVAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAY7</accession>
    <name>A0A1Q5UAY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAY7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14809" checksum="B543694B76B5A415" modified="2017-04-12" version="1">MAAQTVIFCREETATYEVIKPEDFRGFGHEFEKAYTTSHIKNSTSHHRIISYKLGGLHFLVCHETDGFIGDMTKTGGSLANIMDSLAISPETNPTEKASSLSKLRIKRDGQTVPREKTLEIKTRAVNKPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB66</accession>
    <name>A0A1Q5UB66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB66"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="559" mass="61728" checksum="1B38255F1ADD323C" modified="2017-04-12" version="1">MIGAARRWFRRNRKGLAIGAGVLGAGYLAGQYVLSKISEARERMSSERIARENLRRRFEQNQTDCTYTVLALLPTATENIIEALPVEELTKELQKKRAERLARLNAGETAGSDMTSVSPSMTEDDRKSLSSFQSEGYLHTSQLGESVNPEALAPPKRNKTQLWNEVKITSITRSFTLIYTLSLLTIFTRIQLNLLGRRNYLSSVISLANPPADSTISLEDHDDELTQTLGDDFETNRRYLAFSWWLLHRGWKELVARVQPAVEEVFGPLNPREDISLAKLSELTLQIRRKVEGNTEEERRTKKWLSCLLPPTEEEEYVLRESGVEGVADPSSSQTASKLRHLLDETADLIDSPSFSFVLTLLNNEGFSTLVDTKSANEAFQTSGSATTTVPQSFDSMATVVPASTERKTKLANLLAVLARQAHVIGNGTHPPNEYLVAMDQNVRELEAFSAVIYSSNFELELLGASKTAAAEVGDSAEFEPVSASFADVMVEKEPETPSEDIAQSVPVLVDNDVQELETVSPVEQSASEAVTDSAFEQAWGKAVEDGKSPSETEEQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBB4</accession>
    <name>A0A1Q5UBB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000455">
        <property type="protein sequence ID" value="OKP09772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBB4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9469" checksum="D6AD5A703098D3E5" modified="2017-04-12" version="1" fragment="single">LAVYINASPQRRDAFYNLQPDEPKLVPIQDRPYEAPLGSFGKTINTSFLYLQALPGMLCRSQQLGQEWSVSLTLLGISTIIDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBR6</accession>
    <name>A0A1Q5UBR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBR6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBR6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="57"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="43033" checksum="69DECC3F1A339BA8" modified="2017-04-12" version="1">MSQPDYDIYKLGDWELQSGEKIDDAHIAYKTFGNPKLPAIVYPTWFSGAIADNFWLIGEDKTLNPKEYFIIITALFGNGQSSSPSNQPTPKPFPKVSFFDNVRAQYELVTKHFGITRLRAVVGWSMGAGQTYQWATQYPDFMDIAVPFCGSAKTSLHNQVFIEGVKTALLAVKNTRSAGSGKGGLQEDSVELRTWSDRDREVGLKAMGRVYAGWGFSQAFYRQKLYETALGYKDLEDFLQNHWEKWACSKGNHLSPEVIKLALTAVLDPENLLVMMQTWQNGDVSQQEPYNGDFEKAMASIKAKTLVLPAKTDLYFPPEDSEYEVACMKPGVGTLGVFPSIWGHWAGGPGDSKEDVAWLDKQMAEFFAANPPDSVTALGEKLQDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBT0</accession>
    <name>A0A1Q5UBT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000428">
        <property type="protein sequence ID" value="OKP09910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBT0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBT0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025314">
        <property type="entry name" value="DUF4219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13961">
        <property type="entry name" value="DUF4219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4219" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="205" mass="23460" checksum="FD3958B5D5B01E89" modified="2017-04-12" version="1">MSALAHDSPDRAVMAIEPLTGSDNFATWKRLMTSYLKARQVWDVVSGDLQRPDCQFKYAKPITADISPLVEPHLNGAVRQRAIEARLEVEVQAFERHKEWSRREADAYHIILRIHVAGLETSRDLWNELEERYRRMELATFCELFAQLRETTGDRCASAREFVDRVRLLVHRLNAIAPGSIGDRAHIALLLTQIGPEYILIVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCH7</accession>
    <name>A0A1Q5UCH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000382">
        <property type="protein sequence ID" value="OKP10160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCH7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7769" checksum="88FDBE49108F9AB8" modified="2017-04-12" version="1">MQGRRSDFSRESGTTQDASLASWQNDHPLLREDCPRIDAINISQRQLDYFADTIPADLAACVHLYLCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCJ3</accession>
    <name>A0A1Q5UCJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCJ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293414" description="Phosphoglycerate mutase family protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16948" checksum="BF5256A1F2C66B36" modified="2017-04-12" version="1">MVKLISLATLALASVAIAKPTVYLIRHGEKPDSGNGLNTQGLERAQCLRTVFGASSGYNIGHIMAQTPLSSGKRQRPYDTVEPLAEDLGLTVDTSCDRDDPGCVKDVVDGYTGSGNILICWEHDALTDIVSELGDKDAPDYPDDRYVEDRSGEGMCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD26</accession>
    <name>A0A1Q5UD26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protein smt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD26"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20060" checksum="5732850BB95B80B4" modified="2017-04-12" version="1">MSDPSAELQSTLRDLAIGKKGPVQDIPRPIPSKTSAPKTSKPSKKPVADSWEDEANLSSDDEAATKSNLASPSVLSPTISAEGPLDPPPTPISPQTSYPWPGCAGSASPAAGQKDPARRPEKQTAVAERLIAGALGIRAPKRTEEQRAYDRSVKEQEIRRRNREREELAKTREEEERAKASVWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD43</accession>
    <name>A0A1Q5UD43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000348">
        <property type="protein sequence ID" value="OKP10406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD43"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="6524" checksum="0C21BC15B2756E14" modified="2017-04-12" version="1">MNLSQADQLYWKRTLGYSKVEKGVQAANQYDWFVVPFYPLEPLTVRQDVGNALYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD46</accession>
    <name>A0A1Q5UD46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-1,2-xylosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD46"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="1">
        <location>
            <begin position="315"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="641" mass="73204" checksum="1851CA87AB5E20B3" modified="2017-04-12" version="1">MLGANSFAGRRKSLYLSLAVAAALICLVNLIFLTRAVDHSIIRLPGLSLFRPKPKQPQGTLAHDEHPITGLMNEANARWQEYEDSRSTNFRQTVAKYRQTYGRHPPPGFKEWYQFARENNVHNVDDFQQITGDLRPFWALSPKEIRQMAARLQESPGIAGVRIRDHKVVSHSEGWRVETLAAAVERLAKHFPDMDIAMNTMDQPRVMATYEDIQKYLQVEESTRATPPGAADEFTQGRDDLYNETVGINEELDPGWFSVAGKPYMDFAKESCPPESPARNANMTIEDADKLFKSSYGDLISNFTGSTDLCTVGPDLGDKHGFLFSASSNTISRKLLPVFGECKVSVNNDILFPANMYFLKDPRYVYNPKHDYEWDDKADSLLWRGVTSGGIQVEDNWFRLHRQRFVHVANATEMDLEKVSILAKDSQDRYKKIDNFRPSDFAETYFDVGFTEAWGCIPDCSFYEGVWTYKEPKAFSEQFKAKYLVDIDGHSFSGRWRAFHQSKSLGLKATIFREWHDSRLFAWRHFVPMDNRYGDLYSLMTYFIGLNPSASTPEHPSLSHGPSVPRHDFEAEVIASQSREWAHLTLRDEDLEIYLYLLLLEYGRIVDDNRDNIGYSGDGSELDQFDAAHPFPQAVQPLVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDB2</accession>
    <name>A0A1Q5UDB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000319">
        <property type="protein sequence ID" value="OKP10465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDB2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19608" checksum="370C37C009FF73B4" modified="2017-04-12" version="1" fragment="single">MGCPQQRGGKRDSSVIAALKLQEAAQVAIEWGESNLVQFEAKKTEAVLFTRKRGQELRNQIQRARIMVGGHSVSFNHEATRWLGIWLDAGLTLKMHYQTRLRKTRNAESRVQSLCRVQGLAPGLVHRIQVAAVQSVALYGAELWWRGQKDCITGMQRMINRQARAITGMLKTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDT0</accession>
    <name>A0A1Q5UDT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDT0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDT0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="21532" checksum="49BE0F924652EA82" modified="2017-04-12" version="1">MVELDKFKSRYEAVKAVEQDKDKIIEDLMEEVKRLQDALYHEKDDLENQRKLVQTFKSESKMHQSETEEMKLLLDPFTYLDIQFNDSFIQDGQRGGHSAARRLIENVDRYIQNLYRNESSNVPYRIRVYANVRGLAKTYRENKTISEEGTLLSFVQGFNMEDVLCDFVDAGDGKECSDVKIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDU0</accession>
    <name>A0A1Q5UDU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDU0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="111" mass="12282" checksum="62E611953105223F" modified="2017-04-12" version="1">MIDRNHIKPGLFLRGPGNRGAQKPSDSGGAHLPAAPRDKNARPCGTAQSIEIEGPLGPGWIRCWTRRPVQLRGLQDSKAGQNWALRRSCRLFSQVGSVESEWIKTIRRAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE09</accession>
    <name>A0A1Q5UE09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium transporter 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE09"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="2">
        <location>
            <begin position="81"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="25874" checksum="241252446E29C0C6" modified="2017-04-12" version="1">MSTSTEDEPPEDRMMDIHPTSSAGGVFSSRLLQRKISIHGEKVTDTKEVDLEVASVLEAPEVEERDFHKKQVFKGWTLAWLAYQSLGVIYGDIGTSPLYVYSSTFSSEPSYEDILGAVSFVIWALTIMVTIKYVCIVLHADDEGEGGTFAIYSLLSRYARLVRHDPRHTNLLKMQRHNTNDLQKPNLMTRKFMEQSAFIKWALKIVGAFGVSLLLAGKYHSLTILWVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF08</accession>
    <name>A0A1Q5UF08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000307">
        <property type="protein sequence ID" value="OKP11068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF08"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF08"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="151"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37219" checksum="BBC12CFB05296EAA" modified="2017-04-12" version="1">MAIGVAIIGSGNFAKEQHLPAVKAATDLQLKAIYSRSLKSAQTLANGTSDVDLYSDDSGTGNSYDDLLARPDIGALLIGLPILNQPEFIKKALLAGKHVLSEKPIAKDVATARELLHWYQTSIDSSKVIWAVGENFRYMTKFLFAAEKVREMGRVRHFRVNVHSLVKQDNKYFLTFWRKIPEYQGGFLLDGGVHMVAGLRLILGSTDHMIAVSAQTQQLKDYLPPVDTADAVVSTASGATGVISLSWGSDFNDNVFEFACEKGVVTLCFDSVTVNGVEHHIEFDGKGVGPEVAEFATSIIKGGSVAKRQSPEEALADLEVLEQMLQSGEKKGDRVMLRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF17</accession>
    <name>A0A1Q5UF17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF17"/>
    <dbReference type="OrthoDB" id="4387771at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8786" checksum="02130E83124060E8" modified="2017-04-12" version="1">MSKVLKQFEDAIFKGGLYKKLFQKQTPGKRIAPAQAKDNDSKLQMRLDAGESKDGMKNVYLQVNSQAKNDSLVVLALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFG7</accession>
    <name>A0A1Q5UFG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFG7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="125" mass="14300" checksum="5C5D21ADA705017F" modified="2017-04-12" version="1">MASSPRLDDLHILSEFEDEERKALIGEFVRSYEWLSEVPRVSMFALWFSDINILRKAAGPKAYPEFSESRALLASAIPAYDIAEIWADCEQANQAPKRMVQKPSSQPEFPEQDPIEQALVRDNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFK6</accession>
    <name>A0A1Q5UFK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 40 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFK6"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="57"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="383" mass="43791" checksum="0B91E5203362C681" modified="2017-04-12" version="1">MHKCRSINPASGSRAFTPAPRVQVQVQRRNLQDVAITRTGRPVLKVQGGRSSLGGHTATVFGATGFLGRYIVNKLATQGCNVVIPYREEMTKRHLKVTGDLGRVTFMEYDLRNTQSIEESVRHSDVVYNLTGRQYPTKNFSYADVHVDGAERIAEAVAKYDVDRFIHVSSYNARRDSPSEFFATKAWGEEVVRSIYPETTIVRPAPMFGFEDNLLHKLAGVSNLFTANHMQERYWPVHAIDVGAALEKMLHDDSTVGQTFELYGPKNYSTAEIAELVDREIIKKRTHINVPKALLKPFAYYLNKYLWWHTMSADEVEREFIDQEIDPTAKTFKDLGMNEVADLADLTFHYLQGYRSASYYDLPPATERERREEKKYLHVLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG96</accession>
    <name>A0A1Q5UG96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_2993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UG96"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="284"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1483"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1487"/>
            <end position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1582" mass="174971" checksum="DE8821519DF94E81" modified="2017-04-12" version="1">MKPHSSAGQPWGYPMRGLNGGPGRVDLAQMAGQYDPPSVSSQHSISQLQLQAQPPQPPIRQTPVVDLTASGFESHDREPPPKRPRLDVSSGSSLGDAGSTANSAEPRSTPGSAGSRPQLSWRGRPLWSFQAVMSEVPGSENRRDGASASKPPSPPPFPAQPWTNAPPEHQRNTDSSSRDPSPVKKVSTTPYRIETPSAAPIIKGDKVAGFAPWTGNHPEDILNEQTAKQGYYDRTQVSQNESNTARPALYAQLKHRTGLQMLSSVFTAALEKRQNHNAVHAPSTFKPPPRVTLTDNKREAWLRDLANSAVPLRRLSRTIPHGIRGKVLLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGALAVGLEAKWVREWTTNVQQFVEGVFSAPKSNDWKAKMTYAVGLTARLFFENLLDHDHFLEWFLSSFEAASLATVPVWLLMLGIYWNNLMRYRRRGRRLAELLLEKLRQANVAKLDPLQPLIDRLSRFIKKLVHEHTSSMILPNTWDTYKDQVSSCLNLTNKVDRALFQSIAERNARVQRPRHTKQSAQRSPHQRIIRLLDSIRSAHDIVAISSACLDAVDDRAVLVSKLLEWLATPFRYGICRVYVGVRLLRKWKSSGVDVDEHILSFLTHAGINKKLNMDNVYHAISELVRSQTFSVGRYLQWLMAKGVTNYQPSGSKTATETTGDIGLIAQLPVGRLPEHVGNLRKTLMARTGFSVSDEDEMVANIKILISHRLPALFRSTMLLDTSLSSLPSDLTWAVKAEIAQWLRRSVAEYTRANATLRAMLPGALDQSVSALTPEEFYNVRDILETLGDISMLADVLKVASSSDDSTVLASVADTTNCHFDSLSVIGATMDLFRKLIDAYAGIKRFGTPSLDLMFSLIELGLRIPNELNTVAILRQDLSRMENKSVVAACSPVSDHIPDSFGEADPLFREKLDQLLLLGNVMDEPTLDTIFNMLTKHLESGEGKMKLSANDTCRYLAQLRSFQPKHFDVILARWVCSHLRSSDRSILLHILPPLIGVGCVTIRSFLSLAKRLSNSANSIPNAADLPADLVGLLVAHDEDARYLDLVSYRFQLAQQEFISRNTEEALGIVCDAAACLKSGDEKPALKYINLETSMVTLMRELLVRNPDCTSKYCLQRIDNQSSAATVVFQKALDLLLGVDSQKENVSVISEVEKLAITTDDFSLPLCQLKLQVLFHADSANEDRTNLVDAMFKTVVADSRAQKLHWVDLVALMSPDAVRQIRERAEKELFAIPLLEEPVTPQSMTSLENAKLYLTVIEELASSIPNSGTPSIALLLVEKMDTLLHKIINLQSTLNNSGENGNATSTSQGRTTFERSLAFWFSALLRMVVIHRASFIQPSPTLKIGSSHEQSRLLISIFCIALSRLPGDVLRFFPGADYFPRQGTVEDYRPCPGILLQTHALDVAASLIDIFPDEIRHHCARFLKEKCPPFVPLQNDSRFLYLLGPMSDSHPSAILQSASAPSPAASASTPTPTSANFPAGGASSQPTASSLYGGLSENSNCMANRLRLQNRGRIVGPYPIRPWELLEDAAPFVGVNDTAVNLGYFDARRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH87</accession>
    <name>A0A1Q5UH87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH87"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14529" checksum="1A204A0B11386C01" modified="2017-04-12" version="1">MPIHIGISPNLNPSFYLIGDDISTAHNEEISTVEEILSKSSSTTPIGLRVDGQAVQSPQGPDGLPLVRSFYEIFPDHLGNHYRLFQKYGHVIKTTNMGKITYLTDSPEVAAVSLAESAYMTKRSTRISFFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHI6</accession>
    <name>A0A1Q5UHI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein B1A11.02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHI6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="127"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="396" mass="43345" checksum="97A31ACE47A596E8" modified="2017-04-12" version="1">MADFSQYTGPSADWIALESTLPPMPNLPILELRALVNKGREELAAHGMRSIGMFVGANMPNSDSKAIHNGWDNWLSRFSGQADMFLPVASQIQTQDYTVTSRDGASLEVRTYRPSKIPASQKLPVYIHLHGGGYLFGTLSSEDAICSRIVVSRVQNDTPVVVVNVNYRHTPEYEFPTAWDDVEDAFVWVHEHISEIGGLADQVVVGGISAGAQLTASLTLAQLYGDNERLKACPKIRGQVLMIPCLVNAEYYAPRKEMLLNPELSSYVTCAEAPILPVSRIELFMSLLKVKTFPDAGRNLRMNPGNATPEEVKNLPPTTFGIAGNDPLRDEGLLFGKLLSENGVPTDVNVFPGVPHGFRRHGDKLASSKKWDEVMSGGITWALSNPAVAPFEIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJE3</accession>
    <name>A0A1Q5UJE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sedoheptulose 1,7-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJE3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJE3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000022">
        <property type="entry name" value="Phosphoglycerate mutase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="26420" checksum="DAC03939513CCAA5" modified="2017-04-12" version="1">MPDKDAGTPRVFIYRHGQTLWSQSGQYTGKTELDLTENGQNQVRASGKIIVGAGKLIDPAHLAHVYISPRKRAMQTFQIAFSEADQQTLKDAGKISETERLAEWDYGQYEGLLTKEIRALRKEHGLDTEQPWDIWRDGCEGGESAQEVTDRIDNLIAEIRDIHRGNMHGEKHCDVVLVAHGHLLRAFTKRWLGYPMEFPLSLMLDPGAVGVLSYQHHNIDEPAMLVGYGFPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJV4</accession>
    <name>A0A1Q5UJV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJV4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="3">
        <location>
            <begin position="34"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="22529" checksum="DF8BB3ED278C0286" modified="2017-04-12" version="1">MSESHQPSPQTSHEEQHVYQAYMAATSDLRRKLIQKKKHLKLQYGVSGFAFNLLTMVQVIIGAVITALGPSAADHMVAITVLGAINTSCAGLLALLKGRGLPQRLRGSMIEISKVLDFIQHTSVLLKYDKSCVPENGIGPLLEEAFQRYASAEQLIESNQPDTFASGIKLPVNSSATDAEDGQGQGPATYKANGKGPQMDEEMGFLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK44</accession>
    <name>A0A1Q5UK44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK44"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="9310" checksum="F0684DB099AC7039" modified="2017-04-12" version="1">MAPFDEDARSFATCDWQWIRLVQTIYFVWEKVQSAKFARETTRTRKTGRDVLRTMLVLVLCPTDLVRGFYRSTNAFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKE1</accession>
    <name>A0A1Q5UKE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKE1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKE1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="442" mass="50951" checksum="43B042C61F940F40" modified="2017-04-12" version="1">MVSWVNGYLHFSGNRKRGASSRKGMKRLTPTLQHGDYAFKVATPSRWEIFICNDQLIKEYKNLMDDKFSANAVTADMFQTKWTAPGAAEGVHKIPIPLLAKALTWQRNRSSAAGDPYFREFVAEFLHAWEAETQITNEEPYEFCCFETGTRIVAHLTAKSLVGYPLCRDPELINLFAGYGNAVPSIHSFIAKFCEAPQMSDRLDKIFLSEMKERQLRAGSDASDIMSWLWHWTQENEPGKYNELDIVRSITSAVFGAIHTTTQVLVHCLFELATRPEYVEPLRQEVQQAFDHHRGWEKEGIESMLKLDSFIKECQRYNPLDSGTYVFSPNAPVLFDEKFYPNAHQFDGYRFYRLGQQTGKTQDFRFVATNSKYLQFGDGRHTCPGRYMAADEIRLMLGHILLHYDITTKNNEGRPKNWFFKKILFPDMKGLVVLKTRSRVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX3</accession>
    <name>A0A1Q5UKX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKX3"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="10920" checksum="A6B40DB54266FC1A" modified="2017-04-12" version="1">MGAIPEVDPDEPVETKPFKFVTGYDARFPQQNQTKHCWQNYVDYYKCVNAKGEDFRPCRQFYHAYRSLCPKAWTDRWDAQREAGNFPAHLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL06</accession>
    <name>A0A1Q5UL06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase 32B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL06"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05578">
        <property type="entry name" value="STKc_Yank1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000469">
        <property type="entry name" value="Serine/threonine-protein kinase 32B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="556" mass="62287" checksum="5C397BF8FCE34DE7" modified="2017-04-12" version="1">MGNSQGKPVACDDAVNLNHFRLLRVVGKGAFGKVRIVERKDTGLTFALKYIRKEEVVRSESVRNIIRERRMLEHLNHPFLCNLRYSFQDMEYIYIVVDLMNGGDLRFHISRKCFTEEAVRFWMAELACALRYIHSQGIIHRDLKPDNVLLDSEGHVHLADFNVASDFRPGKPLTSKSGTLAYLAPEVYEGGGYYFEVDWWSLGVTFYECIYNKRPFEGRSQETLSENIKRAQPKYYVTNPAVSVPCLRALSALMEKDRSRRIGAIGFESFTSHMFFADIDFDALERKEYSPVFRPSSDKTNFDATYDLEELLLEEAPLEARARRQKPRAELREDATAKEVREDELHRLIETMFEPFDYTLVSFQVKAAEAIAATTNPEDCFPIPTATSTSHSRQLSQPESSARNSSPPQHERSFHAISHNDNLTSVSENLDPNDSVSGHPPPSPSTRASPSPPPPPMPPAPSFHRPLPPAPRPGGATRKMSKGGGVQMVLEEAGSWSELANHSSTLPAEGFEGAGKGKQSNSGMLSFLSRKKGRDRSPKPTEPGVLGKEGARQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM76</accession>
    <name>A0A1Q5UM76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8152" checksum="F3DB7E4F8D23C429" modified="2017-04-12" version="1">MPPPSLPEQNDIVRLWRLASGSRAGDLFFRLHVNNAGMPMPNLGSELTRSKASRPAKVFGEVVFTIIMLSSGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMB7</accession>
    <name>A0A1Q5UMB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoporin NUP53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMB7"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="420" mass="46247" checksum="45CA841CC08F34E8" modified="2017-04-12" version="1">MEYHAVPPEERARDENGNLLPWGYVYKDESRNPRRPPEESGPFGKRRNARYEARSRTRTGTPAKRENPNVAEFGRLFAQQQEEERPVGLPKSSSSGSLDGSRKQTEKVATECILYGYKAKDGEWKVIDKYERISQGMICEDYPRSDPNSASQYAQLLSGGDVVIRANLSADANRKSKRYAGGYHWIKVTFDSTQAADRACFYSPQEVDGHLVFCELYNGHGPAEDSAIPSDSAAAAKLRSKATRTLTSTHSSAFLSGASMDGQPSAFTLPRSFAMNNLSSVTEPEKELSFDSSTTTATSGTATATATGASTSFGSASVHQRSTAGAETKPDSDFMTHIPTVRRTKLRPLTEALPPGPTMTERVLRSIPILSWFTGDIVGDGPQLKEDGTFDHDKSGVYWRFWWMLDQLLGTDVCGLREEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMD9</accession>
    <name>A0A1Q5UMD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMD9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="8154" checksum="CDB6B4E091C3528E" modified="2017-04-12" version="1">MSDENYGSYQSEVYGKGTLMGILPSVTTDPRLLEEQARKALGERSFNYVAGGAGEKATMDSNRLAFRQWKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMR0</accession>
    <name>A0A1Q5UMR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMR0"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="238" mass="27095" checksum="9A8DA106A0B5E01F" modified="2017-04-12" version="1">MACRPDPEIVLYDLACTKNVCFSPVVWRIRLLLNYKQIPYKTIFLEFPDIEPTLKALGIESQSKYTVPAIHHVPSNTYMMDSTPIAQFIESTYLDRPVPLTSELGREIETKARAVVGPTFRNSVMPREANILSPLSQEYFRRACEATLGHPLEDLLEREENSWNSLADGIRAVGELMQTNKADGPFVLGAQPSYTDFFIAGSLQSARMVDEGVFQRNIKFPGYWEIYEACLPYMDKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNR7</accession>
    <name>A0A1Q5UNR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">U2 snRNP component prp10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNR7"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="12">
        <location>
            <begin position="249"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="774"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1226" mass="135847" checksum="926AB465DFCE9317" modified="2017-04-12" version="1">MSDADIEAVRRLQAERNAAAASKKGSRTFDSSSQRTDSSTKASLTESFDTTLYDRNGPDKFAGYDTSIAVNGDDEDVDMEDANGGRHLVGQYTATRSQIDEMAHGNGVEEEDILLGREKAARIADRESDYQKRRFNRGPLTPTRADPFAANAQANVEEGDGQTYREVMALRELEKEEERVKKLIAEKREQGEDVAVPEHQATLTITGGGEVMADAAATAEAASKKRKKRWDVSAEENGTSEDAKPAETKAKRSRWDETPAPGAAEEPKRRSRWDLAPAATPVGQQGLATPMHPSQGGAAAAAGFGNDVAVRPGDWTDEELDMMLPSEGYKILEPPPGYAPIRNPARKIMATPAPMPGAAGVGGFMMQEPENIRSMGKELPTDIPGVGDLQFFKPEDMAYFGKLMEAGDESTMTVEEMKERKIMRLLLKVKNGTPPMRKTALRQLTDNARNFGAGALFNQILPLLMEKSLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDQDYYARVEGREIISNLSKAAGLATMISTMRPDIDHVDEYVRNTTARAFAVVASALGIPALLPFLRAVCRSKKSWQARHTGVKIVQQIPILMGCAILPHLKGLVDCIADNLSDEQAKVRTVTALAVAALAEAANPYGIESFDEILNPLWTGARKQRGKGLAAFLKAVGYIIPLMDEEYANYYTSQIMEILLREFSSPDEEMKKVVLKVVSQCSSTDGVTANYLKEHVLADFFKSFWVRRMALDRRNYRQVVDTTVDLGQKVGVGEILERIVNNLKDESEPYRKMTVETIEKLVASLGAADISERLEERLIDGVLFAFQEQSIEDIIILNGFGTVVNALSTRCKPYLPQIVSTILWRLNNKSATVRQQAADLISRIAMVMKQCGEDALMGKLGIVLYEYLGEEYPEVLGSILGALRSIVTVVGINQMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGRIADRGPESVNAREWMRICFELLDMLKAHKKGIRRAANNTFGFIAKAIGPQDVLATLLNNLRVQERQSRVCTAVAIGIVAETCAPFTVLPALMNEYRVPELNVQNGVLKAMSFLFEYIGEMAKDYVYAVTPLLEDALIDRDQVHRQTAASVVKHIALGVVGLGCEDAMVHLLNLVFPNIFETSPHVIDRIIEAIDAIRMAVGTGTVMNYVWAGLFHPARKVRTPYWRLYNDAYVQGADAMVPYYPDLKADGLDRSELDIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPB9</accession>
    <name>A0A1Q5UPB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPB9"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="278"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="972" mass="106897" checksum="6C70D376134CACBF" modified="2017-04-12" version="1">MTTRATPSALDPLSSSSLNKLHETQPPTKKRKIGAENAAGQLSTTSIVIRAHAASLSDEPLILEPICLLPRSRFPLSWLEDASWSRSDAQPGGLFGADIPALERDLRACAEPTVLAVRLAASGGLYVVERVKRGIYSLSRLARWVQEGDVVVAVKGWQGSRVVVMEVDIEDKLYAALDGMNWWQNAQIEEPPSDLCLGEEFAGLQVDVVFGSSGMDDPNLQTSFVDVLEHRGQSLAPNVIGDDSQMNSSFGLGDSQVLGASDSMDIDAAPGMKQSPEELLNGMREHYLQALYISKTSLAYFAKGPLTRCRTAFQNCDSEQTQRPDQFIDFYREAILAAKKMDLKYRESLPASVREAVLAVSDDEAAVTKKRKTKKKKLGKNGLYPEEDEFVRKWWKDRNMVDASTQAGSREAETRRHISDLRLRETQLQILLILEVMALESTLIVKKDSNGIKPIGEETSTPKKRTKKHQDLNVLLELHLDRLCIWHAVSMEESSAADSAKASSFTDGHNSGKKVESDAVRDFCTEVIIPFYASRLPDKCKLITRKFGVSGGISPTAKKTQKSRRPEPGSEIKREPPAQKPRRSLQRVLTDERAASLPRHPSLSRSKTAPTQHDTKRDSMEPMLPTVMGGSVRGGIQVKRVENREIDLNAAARQHESKLRKVQMLADQKKELDNAIQTLRKPNREVVARDIAEDATKRMSTGGGSSRKSKNPVRNPLGEGVQVMATPRGNRRKDAIVGLPPLPRSLAPSRSFAGEMEDHSLAESPVMIPSSTRRAISFSGADSTPFGSQRASGKRPREAQTQPTELGSIQETPTRPPSQLHFNSQSTDLAHRPSMSSAKGMGLFRVPDLPAPWPDHTDPFSYPQVMAPTTPVSSRRKNNILAPDSSPNPGRSSQGPRSSMITETPPKQQGTNPMLVPRSVPLFAPSTSQVPLYPAVIGSPVKSATLVPVTPEKPQTKSIYEQLGWDDDEMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPD0</accession>
    <name>A0A1Q5UPD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_14114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPD0"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="26159" checksum="0FCBA220E5ED3FE7" modified="2017-04-12" version="1">MASNILPIKVWGKGGPNPPKVAIILEELDLPYEFQPITIADVKKPEYLAINPNGRLPAIYDPNTDLTLWESGAIVEYLVERYDTSRKISFEPGSNESQLARQWLLFQASGQGPYYGQAVWFKRFHPESVPSAVERYVNEMKRVSGVVNDFLSKQDVGQGGPWLVGGRISFADLAWVSWSLTVGMFIKEEDGYDVNEFSYLKNWLDRMMAREPVRKVIDEGRKVIEEAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPG8</accession>
    <name>A0A1Q5UPG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-CoA dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPG8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPG8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="16171" checksum="EC78021A7086F0CE" modified="2017-04-12" version="1">MGHQNTDPAAISLLLEQCRAHGFSPFHVKKDSIGYIYNRIWAAIKRETLLALSEGVCTPREIDAIFKDVLKTPKGPCEQMDVVGLDVVLDIENHYADSRAGIPAEPRAYLQNMIQNGRLGVKNGEGFYNYGSETTETCNVMSTPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQA4</accession>
    <name>A0A1Q5UQA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lactase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQA4"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005990">
        <property type="term" value="P:lactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000680">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000018">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050347">
        <property type="entry name" value="Bact_Beta-galactosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46323:SF1">
        <property type="entry name" value="LACTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="LacZ_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta galactosidase small chain/" evidence="6">
        <location>
            <begin position="741"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116588" checksum="E9AD9D75C703A848" modified="2017-04-12" version="1">MSTLETSPNDWENPHVVQRNKLTPRAFFLPDTSLSLNGRWGFHYALSPLLAPEVDSGGNNEPSVDPKEWTSITVPGHWQLQGHGQPNYTNTIFPFPCDPPRVPSQNPTGTYCRSFAVPSDWDPSAQLRLRFDGVDSAYHVWVNGHEVGYAQGSRNPAEFDITKSVHRGDKNDLVVRVYQWSDGSYIEDQDQWWLSGIFRDVTLLAFPSVARIEDFFVKTEFDQSYTDAVLNVTVSMAATESVQLEVALRNLRGSQETIGCDKLSVIENGTVTLTIPVKSPKKWTAETPNLYDLQITLSSSSTGVKPLQEINHRVGFRQVEIKNGNITVNGTAVQFRGVNRHDHHPLFGRAVPLSFLREDLLIMKRHNINSVRCCHYPSHPKLYELCDELGLWVMDEADLECHGFYDAVARPLDIPESMDYEERKKLTFEKAAQFTSNNPEWKDAYVDRAIQMVQRDKNHACIVIWSLGNEAFYGQNHQAMYDYIKATDPSRPVHYEGDPEAKSADMFSYMYPSVDRINKLAVAEGDNFEKPIVLCEYAHAMGNAPGGLEEYMEAFQKHRRLQGGWIWEWANHGLWDGERNFYAYGGDFDDYPNDGTFVMDGLCFSNHTPTPGLVELRKVYSPVHAWYADGIIFIENRYDFAGIENLLTIYRVEILGSDGSLRLPPIEAGKTGQLKFSPDLPATSEGEIWLTVSFQNTQDTPWAPSGHEVAWFQHQLKTLSVGPCHSPSLPIQVESSRAAHTVTGSDFSLTFSRSTGGLIDWKVKGHQLLDPDSKTGMALVPGFWRPPTDNDMSWALGERRRYSVDDMRVQLRSMNVTHINDRTLQITTESWLGPPVLAWGFVATTTYTISGYGNLVVSVHLKPQGPMPADLPRMGLDLRLTDAFDNAKWLGLGPGESYADKKRSQKLGIYKATTAQLHTPYEIPQEGGNRSETRWLQLSDNRGWGIKVFRNSVDTDKDTGTSFQWVASRYSAQQIETAKHPCDLVPGKTVHVRIDAECSGVGTGACGPRTLEKYLVSCEERQFQFEFAPTFKEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQW8</accession>
    <name>A0A1Q5UQW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQW8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="7787" checksum="20D6E3D49142D52F" modified="2017-04-12" version="1">MSKLPEHVHTTDGKAAGLAELASAYPSSAGQYHFVYMVTPPKYRALVAFILGWLSVVAWALTSASTALVCGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQX4</accession>
    <name>A0A1Q5UQX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQX4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQX4"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="675"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="775" mass="83657" checksum="F4E8A7F63E60905E" modified="2017-04-12" version="1">MADLMEDDLSSGLQSSEEEEEVDMPVESLVSGRAKRSTAGRHMSALIDAAADDDLTLLFEEVEDDNEFAIDAGAAEEEDMGLDSSSEDEDDQGPDAQNDYEGEKQLQKEERKKRRAQNDLRFQTLRKRVKIDPTAVSSMPAPPPRAKKKSERISWLPTVEDGPTRSSSRRQTMVNKELTHARLKDSQEKRIRIIATMKEAEKRKAHLKPKEMTQEDHLAEAARVERTNSKSLNRWELSERKKAEERKAKIEALQNRRLEGPVLSYWSGVATWVDGKLTKVGKVEIKAKTEKEEPRKKKKDKDEKTATESQDAQSATPAPVPQANTAAPGDASTSIPTAVPGEPGALPASEAKPQSQTPVATISAPDIVAAPTSTQEPPSKPSENPSEPPVTASQPVEKDGNKDPEQQPAAESIDSKKEEAKTGEPETQADPSKVSEKQTEPGETITGHQSTSPAEQDTSDKPAETSSTEKSEEKSEENPDVMDIDSGSGTEPIKGDGPQPPIERESPAAAALNGIGTSTDAQPTSGEVSQATLASSTTEPVTEHVTPAAAASAPAPTPADPQAPQAQAQAPPSNAAPLQATPPNIPETLNQGVDQPQQTQQGPQGDLLLQQPTQSQDSISTPVQPEMPRPPPVIEHTGRNLTILENFDDRTAHSKKFSMYFNAKKPPRLTKISSSLCVITSLPSRYRDPETSLPYANSYAYGQIRRMLSQGYIWSSMLGCFVGPGGTAARGVPDRFLGIETKAGEDAEKEKKEEKKPDGGSAGASKADPMEIDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQY3</accession>
    <name>A0A1Q5UQY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQY3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="228" mass="25866" checksum="DDC63304BD5E0D83" modified="2017-04-12" version="1">MTKPSWFEPTNNISEVSEPSADAFALDPSMDFQKIRCLWLISFIQDLRTFMGFSSRFYVQGLSTYPSLYQAVLHLRDEFQRSNSSASVTLGTSPSDYDRLTCLFSICLMMQESISSPPIDAMSNSFWSSGLDILDGALMQSRGLWDFSVQNLRPFLHQHLVETYPDALQKIEYVRRMTEVLGQVSLEARIGVEKCLLNMLCRTNDAQTVFLVDDGWTPDSLLSSMHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRN0</accession>
    <name>A0A1Q5SRN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13378</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRN0"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO90661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="351" mass="36785" checksum="D60020B38C81EEAA" modified="2017-04-12" version="1">MSVPKNQAAWLRKAGSPLELGDAPLPTAGPGELVIRNAAIAINPLDFHMQDSGVFIQQWPAIFGCDIAGEVYEVGNNVARFKRGDRVIGHAINLTSGRPQDGAFALYTVIPADKAAILPAEISFTDGVVVPFALEAAVCALSLKEPGIAMPGVATPALGIPYPSLHDVPYSGKTLIVYGGSSSVGSMATQVATAAGIHVISISGAHNFDFSKRCGADRVFDHKDTSLVGKVIAAVRESGSELIGIFDAISTPETYANDIKILEQLNGGHLACVHPPPPTTDLPANVRAGMIFAVNDVVTPVWKDYITPALQSGKLQCLPPPFIVGKGLEHIQTALEKSKAGVSAMKLVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRN3</accession>
    <name>A0A1Q5SRN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRN3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20009" checksum="7C678C1BC654CB3D" modified="2017-04-12" version="1">MPGELLIQVKGSTVYKDNLEWKELYLPGHVTLGNDISGTALLRYVELDTTIQNNKKRVLIIGAGGGIGMLLVQFAELAGHQVVEASSSNERKESFQRSIGANEVVECRQSGIVGFASYDPFHTGHWKQRHHDSRIDMLDCIRNCDGDTRSVRNYAKLPSTTNTRRFVETIAIYGRSVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRT0</accession>
    <name>A0A1Q5SRT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRT0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRT0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF3">
        <property type="entry name" value="ORSELLINIC ACID_F9775 BIOSYNTHESIS CLUSTER PROTEIN D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="55835" checksum="D00E4C9A645A5103" modified="2017-04-12" version="1">MRLGPRNLLEYNARYRVLICRDCHYAIQKNALGSHLLRHKIYREERQRLLSTINDLDIVEPDDLPLPSADTPPITALPVVPGHCCIVTGCGYLCASSKRMKRHLSDAHGVNGSDDFSSLACSVKLQTFFRGTKLKYFEVSTTSSNIETRLSDDESGHDRGGFRQNAAPSPAQSSPNPGPYPAVDLETLTYFHHFITTASLSLPGAEDSSSPPQYWQKDIVSLALQRQWLMCGLLAISAYHSAAFEDETKARNTHCERATKLYSEFSAGFEITKDDTNIKSTESFQKAKKAGLKIRSFVNCAQWTVNAFTMSQENTLTSTTFPQLESLLRNIRSCVSPESATSSYMYQDSDHGPQGALSNNRSLENDNARAMLLNHIHMLPYRMAEIFGKPDDGQDAAAILLAIKALSECCISSFESDDFSGAWQCMAGWLIKTTDHFNRMLSLQSPAALVVLAYWAIILVERAENCGIWFIHGLSRAILLQIRDHFSTDEAVWALVQEVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRX0</accession>
    <name>A0A1Q5SRX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="278" mass="31110" checksum="C00408993F57245B" modified="2017-04-12" version="1">MRESRPSQLLRKKINRLESEYPGVQLKFHSADPFPDLESFIYTVVIRPSRMMVTEPILIIVSILSGISWGIIYLFSESITRAYITLGLSRTSATFPLLALVIGIIIGVFPHIWDVRKIRDKKRQHMQIQPEDTIMGFAFGTPALAVGLWWFYGTTPPVLWDGHWAIPTGGLVLVGLGVNEIAYTLSGYLTDTYTVYSASAFAGLAFVRALVSGAMPLIGYVLFDGKQSMVPGFVIAGIATAFCVVPFLFFRYGRRLRERSEFAKYSLEVHMRTQLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYM0</accession>
    <name>A0A1Q5SYM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1069</name>
        <name evidence="1" type="ORF">PENSUB_12544</name>
        <name evidence="2" type="ORF">PENSUB_4116</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000734">
        <property type="protein sequence ID" value="OKO92965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000323">
        <property type="protein sequence ID" value="OKP10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000152">
        <property type="protein sequence ID" value="OKP13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYM0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="128" mass="14557" checksum="6C0C0F1971493146" modified="2017-04-12" version="1">MNPKPSTDPSSSGNFSFESCWGCHEDIFNFIGSTTKFAMIIRDYNSDIRDALLCEPVFLAHAQKLERMMLEWEAESSLSDDAPREMSINSSIVFRDAALLFLYRMVWDTRNSDSRVQNTTSSLLETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZD2</accession>
    <name>A0A1Q5SZD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_12375</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZD2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZD2"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO93312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="41470" checksum="1CECFC3440CBF96C" modified="2017-04-12" version="1">MLAARNFSAARQCLRSARMAPSFVTPVSQLRGYASSPDDAVAKFKGQKGSDGKYTVTLIEGDGIGPEISQSVKDIFAAAKAPIKWESVDVTPILKDGKTAIPDEAIRSVQKNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPYDGVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITKEASERVLRFAFQYAESINKKKVRVVHKATIMKMSDGLFLNTARDISKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGQGLANPTALLLSSIMMLQHMGLHDHANRIQKAIFDTLAEGKTLTGDLGGKAKTHEYADAIMKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Z5</accession>
    <name>A0A1Q5T0Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoglucanase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Z5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0Z5"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841058" evidence="6">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="421" mass="43698" checksum="0F0666A0EAC6AFDE" modified="2017-04-12" version="1">MTLSKTASFLLASVALVAGHGYVTSIDVDGTTYGGYLIDTYYYESDPPELIAWSTTATDDGYVAPTAYDDPSIICHRGSAPAALSAPISPGGTVKLTWSTWPDDHHGPVITYMANCNGNCSDVDKTALEFFKIDAGGLIDDSTIPGTWASDELIAASYSRTLTIPTDIEAGDYVLRHEIIALHGAEDLDGAQNYPQCINLKVTGSGTATPSDTLGTALYKDTDPGIYVDIWNTLTTYVIPGPTLYTAGSTATATSAVTTSSATTSSVTASAVSTSASAEAAVSASSTAETTVASQTTLATTSRSDPTGQAQPNHHERPAAGGVVPTTSTADAAATTTTTTSSSSTATSGVLSGACSEEDYWYCNGGTAFQRCVNGEWDASQSMAEGTECIAGISETLIISASKRRREVAHMRRHHVRANLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T111</accession>
    <name>A0A1Q5T111_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T111"/>
    <dbReference type="OrthoDB" id="4349176at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="274" mass="31097" checksum="9DC91355234B5B75" modified="2017-04-12" version="1">MSREMLFCSLFKRSQLASSRQRRRDSKLPLMDLSSLEGPPLADPDPRVIVPVDNIFPRIQQEPPTPESPSHYHRYHNLYTKPLPPRPASADPLDLRQLRNPVSNNRMTSSHTDPSLSDSHLRRMPAQRGRRSYSNELRPGDGIAAADPVRDARSRSPPVNPYLNTEFRVPRRPRSAPLVWSEEEELWVVTEGSASSQRPPTRHSRPPRLETHLSEPSLRSEDPVDEDLDHDALSPPPSYDSHGFSHTHVVRQQRGGAESRWGAVARRLHDLSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2F5</accession>
    <name>A0A1Q5T2F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2F5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2F5"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="72"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO94420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="212" mass="23366" checksum="AEDF970BFC61FF7A" modified="2017-04-12" version="1">MAPTSSPRFSPSEVTVIFFLGGPGSGKGTQSTNLVRDYGFVHLSAGDLLRAEQLREGSQYGAMIKTYITEGKIVPMEVTVNLLSNAMRESLDNNPPAAGTKARFLIDGFPRKLDQAVFFEETVCPSELVLFLDCPEDVMEARLLKRGETSGRDDDNAESIRKRFRTFVETSMPVVDDFEAKGKVVKVQATGSVEEVYAQVKQGIEERGVHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2P6</accession>
    <name>A0A1Q5T2P6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2P6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2P6"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO94508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="507" mass="55517" checksum="08821A27B79A163B" modified="2017-04-12" version="1">MASSWCWSCLSRLRAPSTPRAILPPQSITPRLTTASFHSSAVQYANPTKKKGALVAVKYRQGQTLRRKKKKTTERSRPPAVGERKALRKRIVLSNPNALEVEGMQDLSAETMIDARLRGSVLGLPVPMLDQLRAVQAFKPKQGWSIFRRPGTVLRRDTLEMARLFEKISGEGDAAEKGKVVKKIITGLKGSGKTVHLLQAMAMGFLKKWVVVTVPDARELVSGDTSYSPIEGTNPLQYVQPNAVSALLMRTVEANRQVLSSLNVSQKHTGLPSLKPSSTLEDLAKLGFQDAAIAWPVFQALWTELTATAAAPGMEKDFKARPPMLVTVDGIAHWMKESAYRASDFTPVHAHDLVFVKHFLSLLQNGQASLKNGGMVLYATSTSNNPSIYTLEVALDQLAARQAGTSPSSPDYPSPEAYSGADARVLDLFKPTTGKEPQFELQTLGGLTRDETRGYLEYFARSGLLREEVNETWVGEKWSLSGGGIIGELEKLGRHVRTTAQTTPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2T8</accession>
    <name>A0A1Q5T2T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2T8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2T8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="110" mass="11988" checksum="52721EBAC322AA19" modified="2017-04-12" version="1">MRYVLFSLSAFVLYAIFYFSYINGLDELGRNSVASGKLPGTDAPLRTVYTGVEAIDHVLTLLTTFFYPSLDGQSPTLLLHSISFSGTFGAAWTLVVLESWRKGNVGTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Z9</accession>
    <name>A0A1Q5T4Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000704">
        <property type="protein sequence ID" value="OKO95296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Z9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="8068" checksum="86C0E9A5ED0FCFB8" modified="2017-04-12" version="1" fragment="single">LHLVIRQEVLDSIAIGAPQQRPERVGILISIGRVPRLDGIDIQVIESVVEDGLGVRRCVAAILQCIIIKQDWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6S7</accession>
    <name>A0A1Q5T6S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6S7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6S7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="60801" checksum="DB4C13243452C559" modified="2017-04-12" version="1">MALMDFLSRHKPAINEKSSNSDLDHNSTQNHNVGEKSDTKSVQDSNTQDDEHQYPSKFNLFFIILSLNLALFLVGLDNTIISSAIPKITDEFHALSDVGWYASAYMLTTCSFQLMWGKLFTFYIVKWTWLVALFIFELGSLICAVAPSSTVLIVGRAIAGVGTGGVSNGCFLLVAYSAPPRQRPALIGMMGSMYGLAAIAGPLLGGVFTSSSKLTWRFCFYINLPLGFVCALVVVFFMSSFSGGKGGTVGLKEQVKQMDVPGTLILLPAIICLLLALQWGGTKYPWDNGRIIALLVLAAILQSVFVFIEYRSGDRATLPFRVLKNRNIWGSSIFGSSVVASFFTMLYYIPIWFQAIKGATPIKSGVMTLPLVVSYVIFSFGTGSLTSVLGYYVQWGYLTVILSAIGTGLMTALKVDSGHAEWIGYQVLFGAGIGCGMQTSFSAPQTALPLEDIPVGTAIVMFTENLASAIMVSVAQNVFTNQLKTNLSEYAPAVDASAVISAGATEVQQLVPEKLYQVVLFAYNKALDQTFYVGVALSCLGIIGVLGLEWISVKGKKGKDSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T825</accession>
    <name>A0A1Q5T825_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T825"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T825"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="68" mass="7865" checksum="D959ED2613C6235C" modified="2017-04-12" version="1">MFSGMFRRRQAVDPAAAESPGSYEVPLYTNAAYYPNWRVYKKQPPSSLRLGFISHVFYAFAWYAANHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T878</accession>
    <name>A0A1Q5T878_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_10622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T878"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T878"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO96447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="26328" checksum="8FE9DF26C4549820" modified="2017-04-12" version="1">MSAASIPPPSADQDYKSSLLPLLISNNVLSFGTYVLKSGRESPYFFTSSLLHTAPLLRATSAAYASVLSAEPFVTTAADGTTKPNFDIIFGPAYKGIPICAAVTNELAVRDSLSGSPQGTWDNVSYSFNRKEAKAHGEGGNIVGAPLKGKRIVIVDDVITAGTALREAVGIIEKEGGIVAGVVVLLDREERVSDSEPKSAIGVAQRDLGGNIPIRSVIGLHDLIEKLSDKIGAAEIQRLKDYRARYGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8J2</accession>
    <name>A0A1Q5T8J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-N-acetylglucosamine 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8J2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8J2"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="138"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="40844" checksum="04204C33E770FCC3" modified="2017-04-12" version="1">MTLSSEKVAIALVGGGTIAPLHAQYLLSSSTCTLIALIDPFPPGQELALQLGVPRFTSLEELLASTSKVPDAYIICVPSSLHVRVTEDILKSSSPKAILVEKPFSTDSKSGGQLLELAQQKSCQLLVGHHRRFHPSVVRARQVIERGEIGKITAISGFWTAKKNDGYFTFADWRCSRSAGGGPIWTNFVHDIDVLHYLTGSRVARVWAIETMGRRSRTEIRGNDFVEEGAAIMLQFANGVVGTFIVSDNVASPFGWEAATGDNPLYPPAPAQVDSYRIFGTEGTLTEPDGTLWKYHTEQATKLGREVGWNVPMQREELESSDEIPFQQQAEHLAKVARGEESPRCSGEDGLDAVRVCEAVIAALEAKDGLPIDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8J6</accession>
    <name>A0A1Q5T8J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8J6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8J6"/>
    <dbReference type="OrthoDB" id="4366053at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012772967" evidence="2">
        <location>
            <begin position="18"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="49080" checksum="0392C548AFC63B42" modified="2017-04-12" version="1">MVKTTYAVTLFAAVSMAAPMAPSSNDYTGVEPMRRDGTGNLVGAGADGSLNQLVGQLYSNLKKQNADLARQKTPKQRAEVAEAAKHQKPSILQSLPLIGGLLGNPKRSVEEKELHDRSFTGDLSHFPILGELFGGNQDKNQNTNQPLGSGDAMPAMSARSYDQNYGQNYGQNAGQNAGQNAGQNEGQNEGQNWMQNYGQNEGQNEGQNEGQNDGQNEGQNWLQNYGQNSRRDLTSELSSLPLIGSLLGGQQKKDAAKRDSQAKPESLGLLSFVKQLTSGGSETISHRRREDAGLTNALGEGIKGVDVSDLTNPNNLLGDDLDNLEAEALAAAGAATPSRRDFFDVLKTPQQLSEEQQAEKAQKAKEGDKGKDEAKPAKPAKDDKKAVESPLKELFSESGLGGLVGNAHHGVGILPMNGRRDVPVEARGEPIQGATLPDVLLRGGVLGKVAKFLSPGGLAPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8K3</accession>
    <name>A0A1Q5T8K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8K3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8K3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="30938" checksum="60371DEF21FCD1C7" modified="2017-04-12" version="1">MDTDTASDSEPNLQPGVSHVHTYISVDTDSEDGGMQLEPPDGEMLRFAEDDSDIEFDERIMGVAMEEDRDENDFTTRAINPHSSIPNAHNTPSQPGNRDHPSLGFYAQRERPRPRPRRLRTQGHLTEEQHAALAVLSNWELLVTHALNSHRTIPQTRRRFQAKLLSPNNTTLENELYASRFIVPASKSELLPPASSGSGRAYETASGADNTTAFLVPGSYREVVDGDERSWWPLGKPRVKRKSDRGVVGVLGRGRDGSGSGGSGESSRVVSRGGSRAGSRGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAJ9</accession>
    <name>A0A1Q5TAJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAJ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAJ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5 8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="38182" checksum="5D23381DF230A965" modified="2017-04-12" version="1">MAESQRPRVFFDIQIGDQKAGRVTFELFNDGSIFHRVIKQFMIQGGDFTAFNGTGGESIYGEKFPDENFDLKHDRPFLLSMANSGPGTNGSQFFVTTVPTPHLDNKHVVFGEVLNGKSLIRKIENMPTQSDKPKTDVTVVDCGELSGEDWANADKRVQDATGDPYEDFPDDHQGEELTAPLAFKIASDLKGFGNTAFKKGELNLGLEKYQKGLRYLNEFPEPADSDPKELGEQMKSLRFTLHSNSSLLANKLQQYQQAQSWASYALQVAEAAKAKDADLAKVYFRRALARQGLKEEEEALKDLQEATKLAPTDAGIINEIAKVKKSIKDRDAKDKAAARKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB89</accession>
    <name>A0A1Q5TB89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB89"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="20748" checksum="E6B34AF7CB9B4DC6" modified="2017-04-12" version="1">MDMEWMLLYVPKEGNEKRVRYFLSKEADMNFQGKLKEGTPLYPTGLETDSKYTTSARDAPGGYLAPEQGLAEVWADATKASPALFDAVKLEKPAEFRLLMAHNADTRVRLQGESLAQCVLESECESIKELGLEWDIKAKTRELARHVGTRCGNRRYRRPRGQHADETVSAQRNGVLQSATIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCG2</accession>
    <name>A0A1Q5TCG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCG2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55312" checksum="EE65ED86A651F10C" modified="2017-04-12" version="1">MAKASEINEAPEAVEMDVVKEHMNYDLIDREVAEYANATIVEIDEATNRRLKRLIDTRVMVVMVITYLIQTLDKGTMSYASIMGIQEDNHLVGQQENYIIQRVPIAKWLSGNIILWGVTLALQAAMKNFEGLIALRAFLGVFEAVSQPAFTLLSSIWYTREEQGGAVTFWFMMNGLNQILGGLLAFCFSFIPETSPISSWQALFMAYGILTVFWGAFVGWWMPDSPMRAHCFTESDKHLMVERVRRNRTGLQNRKFRKEQVWEVVKDPQVYAIALIQLLLTIPSGGLGAFNNIIVKSFGFTTWQTQLLQMVSGVVQLTAMLSAVWIEKRYKQTIFVMMASVVPTIAGVVVLLTVPFSHHKRVGLLFAYYIMIAYWGCAGLALSIVTRNVAGQTKKSVVIACNFVFWAVGNAIGPQTFRSKDAPRYFPALAAVLGCFVLLEVVLLSLRTWYVTENRRRDRKIEQGEVAADTAFAHSFEDITDRVRTIEFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCL6</accession>
    <name>A0A1Q5TCL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Meiotically up-regulated gene 136 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCL6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCL6"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="39849" checksum="46712DBBFE3D6347" modified="2017-04-12" version="1">MLMFKSQTSPYFRRVLLAFICLFIIFWATVSLHPLYFIRDVKSIVTTPSDRLSSPRYAFATILTAEGDVEYPAVEEPYLKAARLLTYQLLHNPRTRNGSHEIPFLVLVTPDVPQTHREILKNDGATIVPVESLGRDWIHPKWGRWSGVLAKLNLWKLEQYEKIAFLDADSVIFRPIDGIFESPETNLRDTLTPKLNTTAQLPEHYMISGIHDPWMEEFMPPVEGDEFYEKNNYMNAGFFVLRPSKTLFDYYVSILDTPDQFDSAYPEQNLLNCAHRTDGPMPWQDLGPGWNFKGGSQSDYEGGLKSIHHKWWRPIGDGYMAARIANAMEEMEIYFQELKGQAEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCY2</accession>
    <name>A0A1Q5TCY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCY2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCY2"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="92"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="408" mass="46074" checksum="5116292DE238B851" modified="2017-04-12" version="1">MTSTIVETDTSRATPATINLSIFPDGLKTSGQHPPVYSRVRPYIDFPKVHGGPTVWKAEDYRENPQLWTHHFTGEEIKELGAVTDDFIQKDLPLTGISKTNFPLPKLSIRLEALRRDLIDGKGFFLFKGIPVREWDLRKCATAYMGLGTYLGYFTSQNGRGHVLGHVKDLGEDPTKTDRVRIYRTNARQYFHTDGSDIVGLLCIAKSLSGGESDIVSTHHLFNVLQERHPDVVETLVEPNWYFDRKGEVSDGQEPWIRGSIFYLENERAGDNPRVYARFDPMNVTSLSRFNSGPDAKIPPLSEKQKYAMEIFEKTCGELALHMILAPGDIQFVSNSHIFHARTAYTDHPPGAVDENGQPARRRHLMRLWLSAPESEGGWKLPYRDTLEKKRGGIQVNDQAPVCPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCZ1</accession>
    <name>A0A1Q5TCZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="506"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="670" mass="73156" checksum="4753B1B7458418B4" modified="2017-04-12" version="1">MAALHGWHPGEVAIQRKLGYADVVRDHWSIVGSFMPQQHRIFHTSNLPFIPLTTLDDDGRPWASIVSGSAGAIGFVKSPDARTLSIHARIWDGDPLLDTFKAWASLKNPQDVITERFLTAGLGIEFSTRRRNKFAGLIRGMQRVTASDYQIDLAVTETTGNCPKYINVRKLVAFPQTQPGIAYRNQNLSPDERLPDEVRDFILDADTVFVASVYNSKKETAAEYPSHAGMNARSGLPGFIRVSPSDGRTVVIPDYSGNRFLTSLGNIESSGLAGLTIVSFSTGDVLYLSGTAENHVGPAASQIMTRHSSLTTVKVTGYTLVRNALPVRQQPGTSVERSPYSPKIKYLVEETGSEMSETEGHKANLQEAVQLSSDLAVFKFKVNTNPGTAGLKIRPGQAIVLDFMDWIGPPRYRHMADSAPESINDDRVRTWTVSSAHEGQNATWFELTMRKMPGGAVTGALFNILEDYSLNQMGHLVKFNGSVSAEIVGITGDFFINSDKLDVSWIAGGIGITPFLAMIQALEQRGSRAEGDIFLVLATREPEIMLRLIQPALERMAPTVSIKVEIFTNKAVDMEPFNRQNAKITVHQGRIRPEYWRGTSKDKEVFICGPNGFGDSVVNGMQAAGNVCRGGKTWAVSWGDAIAVKYPESCEETVAIPSSIASSVGGLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD08</accession>
    <name>A0A1Q5TD08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000680">
        <property type="protein sequence ID" value="OKO98106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD08"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="29318" checksum="69C04D1ED43C0B79" modified="2017-04-12" version="1">MLDFHVSFGTGRLLAADQGGSHNWTKYLFPEWIRRVKSCVRAAVDADAMYEKFWNTLDKAEQDGKHYRIDPEIATQSLAPDDPTALSELETETMRYMGLPDTKAKTRRLRLAMLASCFFCTLLSLPRYDPVLGQYRVRLAIQSRWPEDDTISQSLHSTLETASFVVGGIAYPYKSPLACLNYVDSLDVSLHITLTLDGKESHPISGFPLTLKQMMYLQLPLSTMPATSPKRGGPCLVSGRLKRRCLEWPVLGEPGKSAWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD93</accession>
    <name>A0A1Q5TD93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD93"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="6805" checksum="559D05F3CE517648" modified="2017-04-12" version="1">MPNIASDSACYEARVFELAEDIVQGRMGGTPFRYLIASMKFSPRGNRAMSYGCASSQLSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE45</accession>
    <name>A0A1Q5TE45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE45"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="361" mass="39675" checksum="50DF1DFBFA87331C" modified="2017-04-12" version="1">MAPVVQELTLTITEATSTFVTVFPVGSDQARTTVNYVTQTLTYPTTTIVVVDIASTPTSTPSNSPDAQGGLTGPEKGAIAGSILGFFLILILLYCCCWCGSSSSQSSHGGIRTRQTSPKPHKSEKSSIGGYLPPDLEVLEVQPTSISNVNVGSNKFFTKPNQPVAEIAPRSVPTRPVDKTVQIVDAGNQPSGRNYKETTTKKNSQPSTGAPAPNNDNASSKTEPSLKREQPPEKETPSKTPQHHNHHESYPLLNEAQKLRELTFRLSWNRCLRQATDDMAKLIRTGHWSAKDLKFGEDRHFRIARNRYLPGLWYERSANVGDRSQKTLLYVQQLLGADRVNPDLPPQEVPFHLSELSSLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEV1</accession>
    <name>A0A1Q5TEV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEV1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEV1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="12115" checksum="94C72C4E4F86FE9C" modified="2017-04-12" version="1">MPESSELPVDPEPPANAFVRNHRSPTPPEALELQEIQTREDDEQLNYSSASASSGEEYRVTTRTASRSSVRRPRPKRKGAWKKVCSFWTHNVTLTVPQKSNRDHLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFI4</accession>
    <name>A0A1Q5TFI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric reduction oxidase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF69">
        <property type="entry name" value="FERRIC REDUCTION OXIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="169"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="457" mass="51244" checksum="0A66B5FD03772D55" modified="2017-04-12" version="1">MAIFFGLNIIFAWNRVQYSGDFNQYGYLTIANGGLALLFGSRNNLLSLVTRVPSTTLLMFHRWVGRAAVFYASLHLYGESRDWIKEGEVSTVFANMRIQVGLMAWLSLALIFVTSLSIMRRQQFEVFYYAHALFIAFIIGALIHADHAPEFLLPGLCLWALDRVIRFSRNFRRIQILSVTPYATDVMKIKIRGFKTSYPGQIAWIQISEVSFLNWHPFTVASAPGDDEAMFLIRGLGGYTRRVQDLAKKNNFEQASIAEIPFPWKIRVDGPYGVSHTQWEAYPVIVLVAGGVGITPGLSIASHILRHATGTGENIEGRPPWHVHLLWVIKDEQHVNWCQEELQNLFAMSASPTVQATFDLTIAITGSARLEARAANDDEFIALEGQTSHDYNGPGELIRGRPNIVQWFRALRSKRDGLDGAVNVCGPRSLISMVRTAAADLSGRGGIFHLEEEVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFK6</accession>
    <name>A0A1Q5TFK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFK6"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="41457" checksum="781728D920CAEF85" modified="2017-04-12" version="1">MIRDAGFRPDDFASGSDSSSPSSQLLGPTPTMLSTSLRRAAWAPLSGISRSTQNVPSSVLGATRHVHQRQYSSSSSKPPVPPSDGSRRMDTSTPAKGVNSSGEKGKSARRRGKENGARNGSSKASQQHAAFSKLPSVPSTQHRQPHDVHVASFFSIHRPISVTTTVPPIATPEAFDAIFSKKFLKNEADDVIFTLSSTVETMENPTPVMAESEEQFNQLHQSFTTDANGELRMLDGPEAGMTVEEYTRRLQPFRPPPPPVPMDMTSSADALTDQETSTYSTVLTIREQTHADGRKTYEASTGPFVRSDMEDPEHGFTIDAPTGSTSGMTYMERVRHNRTMHAISTKRRRKIKMKKHKFKKLMRRTRTLRRKLDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFU8</accession>
    <name>A0A1Q5TFU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFU8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFU8"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="36790" checksum="6973F30497F3C87C" modified="2017-04-12" version="1">MGWFWADTQSKAPVAPHPTTPGAAIPPGCPMHESGSAPAAAPKTAEPPSNCPMSKAKDSPFYATQKPVDTPAPPAPAAPQQSTLSKLNPLNYMFSSISQERAPQQTVDLSVDRETSSIPRGDSQGNWEYPSAQQMYNAMLRKGYTDTPQDAVESMVAVHNFLNEGAWNEIIGWERTFAKGLGAGWERCRRGEENLNFQLMRDEMTGNIDQATEPRLIRFQGRPKELTPKARIFQGLGWVYPAKFESPPPFDRHDWFVQRQTPSGPKEVRYVIDYYSGDPEPNGEPVFYLDIRPALDSPTAAVERLMRWGGDVWWRASGGAVREPGQSHGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG76</accession>
    <name>A0A1Q5TG76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="36057" checksum="DF86D3B9C3D816CA" modified="2017-04-12" version="1">MSLLGLPNELLLMIAEQMSSSKDINAMAQADRFTYALLNKYLYDQNIRKSGSSALLWAAKHGQLGTAQRLIKGGANIETYPGPLFQRPLHVAATYGNVEVAQLLVDHGAKITFLDGHFKTALHHAAENGHAAIVQMLLRHGHLLMEQTNHLVPETPLHQAAKYGHAEIVRLLLAAGCKVNVTKFGTGETALHLSLEHFKHQIRHKGKGKKISVKKRDARKAKTAVLLIEHGADVRALPRSNKTPLELAIRVSYVDVVRHLLKKGASPNVRVSIIYSNLPPSPTFPFSTYTPPTTTIMDLAKSCGNNEIIYLLHDAQNKMYATSRNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THB1</accession>
    <name>A0A1Q5THB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THB1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="15394" checksum="A295F90D9ADDBCAC" modified="2017-04-12" version="1">MGPLVPYFTTTKTFLQLLGKDHLQKALSSAQPPVFGDLDEIHKHGFPNVVTLWYAYKLINDVPAIFPATQALRGPYYGSLRTELNELRAKPGLSPSDLGDVSDDSEQERHMERVKAFAEKNGQKRRADHEKKDKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THF3</accession>
    <name>A0A1Q5THF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein XRCC2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THF3"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="457" mass="50970" checksum="900E4DA33F3378D6" modified="2017-04-12" version="1">MAASLGDTSLADIHHEGLDQLLNDLANVYPTSPGQQQPLLGVPVIDALLEVFMQRLPGMSIETERQLNDTALPEQIVTEDEEVLLRHENLDDETAAPGDRPAQVGRDSSNVFISSSTPRHKRPSPVVEISSSLSGAGKTQLLYYMTARAILPRNYGGISIGGLEAAMVWMDADDRFDVYRLKCVARELLRQARESTDEDILDEDTEFFSDAQLAELLTSSIQHVHVFRPQSSTALLATLCTLDKYLYDLSRHHSASRPLHMLVIDSVTAYLWKDKLRDELARTEEIGRSRAEIDQQRALKQTFHLSDLYAEIVNDLKRLQGRFGCAVIYTTTVSSGRPSASNTGQSGPPGPYDRLPSKTPSLRPALPAPWGTFPILRLVVHRDAVRPFPPAMSAHDARRDASMRQSVVRQGKFSAWVNAWGREEWPRRVIDGVNWYNGGCFPFYVRATGVEIPQPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TID5</accession>
    <name>A0A1Q5TID5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TID5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TID5"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34015" checksum="91CCD4B1F452CC92" modified="2017-04-12" version="1">MVGKRKRETAVVSRSTKTKEASPPPANDAQDIFRKYFESQFEPIEADVPSKRDTEETGSEDKDDIENDEDISEPDSDWDGVSEESDEDNVVEVVEHRDASFDGLVDKKARKAFMSAKPPSSAEEKKKTTKTTKKDDSDDDANDALNLKHDLDLQRLLRESHLLDSASELAPTGKNRLKALDLRMQDLGAKESLYKQKNMPDAFRQGIKAKAISRDEKRRREAKENGIILEKPSKVTKSDNKRRERGIGGSSIGKFSGGTLNLSKEDLHSMQSSRGRSSRGGRGGRGGRGGRGGPGGRGGRGGKPGRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJL8</accession>
    <name>A0A1Q5TJL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJL8"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="35242" checksum="C1B4E1455DAC9394" modified="2017-04-12" version="1">MDLPSPTFSFNLPSVHDDCQLECRLYLPHQLQNIESATQSSVHGAIVAHPYAPLGGCYDDPIVGFVGGELLQAGYIVGTFNFRGAGSSEGRTSWTGKPELGDYVSLYGFMLNYLQELHSTLASRQNAPPSEAIHLVIGGYSFGSLIASHVPPLDVMLDLFCNGPTTPTTPIYEIGSAAQKIAAQSTRHLPPAKQNPDQDNQADQPTSRVVTTISYLLVSPLLPPVSQLLTAFSALSVSVGGKSSAQARPAGRPAEQLSAHRTLALFGDQDTFTSARKLQRWSAEMARMSQSGFTGCEIEGAGHFWRENGVETRARRALQEWLQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJM4</accession>
    <name>A0A1Q5TJM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJM4"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="196" mass="21300" checksum="96C1A7B20BEE5C22" modified="2017-04-12" version="1">MSPAPSPGNDVFPDGPSMRQPALSWLYRLECDIAKEELNVGAPHGAGIIRSVANIVRGSIKGPGIEATILSLGGADWATVIKGTHSMKLDARYTARTSDGHYLYIRAHGLYRPGPGTEYAKQVEQDWTQAPKAVVTQDDVEFFSHLRLEAGPGPYNWLNGLVCLGVMVCEGEKIWIDAYHLTNFPGIKPEDVVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJN5</accession>
    <name>A0A1Q5TJN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_7882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJN5"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="90"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="242"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP00425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="558" mass="60891" checksum="BA258EA8A7E3B723" modified="2017-04-12" version="1">MATETSQSSHPTSDWQELVARKRRECQDKIPREWTLSEDVLKEVPQHLLEYNLPRRSGLLSDIELDITENYTATELLVKLASGQVSSLVVTTAFSKRAAIAQQVTSCLTETFFPEALERARFLDEYLQREGNPIGPLHGLPVSLKDSFCLEGVQSTVGYVACLNNPPATKNSALVTMLLELGAVLYVKTNIPQTMMTGDSENNIFGRTLNPHNTSLTAGGSSGGEGALVAFRGSILGVGTDIAGSIRIPSLCCGVYGFKPTTARVPFGGQFSGVMEGLPGLIPSAGPLGHNLMDLKLFMDTVIGSGNAWEYDHTAAAVPWNKTATVGSDRNGSLTIGVLSEDKHFPLHPPVKRALERAVEALTKAGHRIVRIENDSKENLSVAYASRLAFQYLTYGPHVDNIGPSGEPLVASVAKFASPMFSGTWPVEQEQDTLYKVSELHVAREKVSNAWRQEWVEKKLDVILAPGSQNTAVGYDTYGWPPYTVMWNLLDYPACIIPFGKASKELDPEEMKTGDDVQPDYHPEEVDGAPCAIQIVTPRFQDEKCLAAAELIERAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKY5</accession>
    <name>A0A1Q5TKY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKY5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="224"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="505"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="776"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="845"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="886"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="919"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113215" checksum="2A962F263663138C" modified="2017-04-12" version="1">MSLPLYYAASFGLEFVLDSILQVHHSNVSSSEIVNAQGGLYGNTLQAAAGGYNERVVQMLLDLGADVNAQGGYYGNALQAAKGVRNLSFVVQDVEIDVSSKELDIKQQTELQGIAKSCRTVLSELENMIDTYRDLDGTGDTKRSIARRTWRRLKWEPSEIQELRQRIISNIALLDAFNGRMTRNSIRNLVQHQDEQKHQALLNWLSPSDYGAQQTDYIARRQPGTGQWLLDSPEFQYWISGSKQTLFCPGIPGAGKTILTSIVVQELYEQQKTDRTVGIAYLYCNFRLRHEQGLAHLLASLSRQLAQGQPVLPSALPWMYEEHNPQGTRPSVEELCRVLDSLAQTGGFSKVFIIIDALDECDVSNRSCSRLLDSIFNLQSECNVNIFATSRFIPEITERFKGMPTLEIRASKEDVTRYLRDNLSILPSFVSRNQDLQEEISTAITTAVDGMFLLAQLHLNSLIGKRSPKAIRSALKGLSSDVEKYESAYDDAMNRIQGQVPDKSEMAIQVLAWITCAKRPLTTIELQTALAVEIGESKFDPENIPDIVDMVSVCAGLVTVDEESDVIRLVHYTTQEYFERTQATWFPRAHHDIGRICISYLSLDVFTVDTWLMKTELDTHLSIDLHDFQCNHPLLVYAGHFWGHHVNTRVHSDDLETSDHQIIEFLSDVSKVNSCVRTLLWYELPSHSYCQCHYLRTRGYSRGYPVSSSKLATGLHLAVWFLMPRVIEKMISRGWPVDSRDSSGRTPLFWAACFGLSDIVSLLLEAGADPVMKDYDGETPFHAAACFESVNSTSIVRSLLRKAANSHLKDLKGNTPLWRASQHGQIALVKLFLDHDPNVNHGSVELDRVLHVAAANGHNEVVKLLRDRGADPGAVTGVEYYHGTQMIQTPLLAASMEGKESVVKLLLGWNVDVEVKNENSCSALSIAALRNHGEVVQLLLEKGANPNSLDDVGRTAFHWAAFWSHNTILESLAGYSPMGPNKRDFHGRTPLHVASALGHLQSVLALLAMKDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL50</accession>
    <name>A0A1Q5TL50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL50"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000102">
        <property type="entry name" value="bZIP transcription factor hapX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="519" mass="55718" checksum="B5DD1E8D3C183EAA" modified="2017-04-12" version="1">MATTGVSITPAQAIVAVPPLAMAPALAARPSVAPSPGPGTPGSITSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVQELEEQIKEIEDGHEVRIAAFTEQISNLSREVEQAREEVNWWRDRCHSLEKEVSIERSAKEALVKEFRSSVSASTIHQKPSMPDSVPLPPRNRPSTRSSRMEGVVATSADQNKEDDNVPLGCNSCTSTHCQCIEDAFGMPIDTHESSRARHPPHGVGSPVREMSEPQIKPDPEEMEIDFTSRFAAVPVQASSNNTSNVSSPPVDPCGFCQDGTPCICAEMAAQEQQQQQQRGRRSSFENNRLAPIQSISQFTPPPSDGDVRSEVVLPPISQATNPCANGPGTCAQCLADPRSTLFCKTLAASRSSSGTPAGGGCCGGKGTDGGCCMSRSAPTSSTARDNPSMPPQSTAPKPSTPSALTLSCADAFTTLSRHPNFSRASDEISTWLPKLHTLPNPQELALAEARGSRPAMEVEAASVMGVLRYFDRRFADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLE8</accession>
    <name>A0A1Q5TLE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLE8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="7930" checksum="F56EBDF5E71F193E" modified="2017-04-12" version="1">MSSAMLNAVPSFKEQENKGNLTGSVSFRRCLSEGFVVCRSILGGWHVDESPDSATNRDSHARGAYRADQLGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM41</accession>
    <name>A0A1Q5TM41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM41"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="264" mass="29443" checksum="CC28A11D5C2EE648" modified="2017-04-12" version="1">MGRAADIEVARKEGIEIVAPSAIPIEEGAAVPRAMTIDEIQQMIRDFVEASKNAIRAGFDGVEIHGANGYLLDQFIQDVSNKRHDEYGGSVENRTRILDEIIKAVVGAIGLKRVGLRLSPWSTFQGMRMDDPIPQFRDVIKKASQSDIAYLHLVESRTSGAMDSDAHDSLDFAYDLWNGPLLVAGGYTPLEAQKLVDESYPEKDIIVIFGRLFISNPDLIFRVKEGLKLSPYNRETFYVMQSAVGYVDYPLSKEYLFNGQEVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMG4</accession>
    <name>A0A1Q5TMG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorting nexin-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMG4"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="416"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="872"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138783" checksum="BB6E518714C5C58F" modified="2017-04-12" version="1">MVLQRRDLILAGVGGFIAWGLLVRWLPILRYLGYALASGAVLASAGFLGLIVLTTRPRNDKTKSSKEVSVAFINPNHWRKEVLNARKVARYRPRPLYPQSFVVSEGIDELLSLVNRQFVTSWYHNITPNPTFANEIDRVTRVALDNLRDTLLAEDLISLIVSRIFPVLTAHLREFDVAERSVRGKNLNRNVTESEELDLAIANKFREGRLHPAVGLSASDQKVVQQEYLRKIATGLLPQLFPESVLKSRIVSVLLREIIACAVLLPIVNALSDPDTWNQLTEAYGRTALQDRKTVRKLRAALDEHASPAPKHKRTQSFPKLSPQDSERAFERFVRTIRRCNNLSDARRFRALVSSQLKRESMVEGQDQVYLRRLETGKRVLDQKVAKLSLPGEAASSTPAPVQPRRDSVPAPQETSLVEVMHSASGLSYFMEFMDRQGLMSLVQYWIVVDGFRNPLEDDFGDETTSGTVTWTAADRNDLALLSETYLTKAELKVSQDSRRTVKNFLSAGKRATPEQYRKARTVVFTTQSAVLEELESTYYPKFKESDLYWKYLASDEASGGQLPAPRQTPPTITFEAPERRPLPPLIVRTSSQPGTKPPRDLRRAAVSSSDVRSMGKLFDDEDSPRRSIDSERSAPLFDDDYDTDNLAMSTASLGKDSHNGENDATQSKVLETMGAALNDIITNEPKNGKVDDLRNSDLRSSDGASSSSLFGSERPEMALHASSDGSRLDSHLPLDRTKKSIASLGLVDHGSRLGVFEDDLFPDQQKFIEDEYEEPVGTDEKDPADEVHEAAPGDLGLTEAIEVLTVDIDKLTAQDSVVEALTRKAELTNNTAELRILRKSKASIQREIHRKEMQRQQYIIQESDNSLYGRSTVRIKSIVVGKEEDDGREFAMYVIEVQRNAGEQMPAASWAVARRYSEFHELHQKLRMSYPSVRHLEFPRRRMVMKLQKEFLQKRRLALESYLQKLLLLPEVCRSRDLRAFLSQRAILPREEVNARGTEGETKDLVTRIYNSVADGMDDFLGNFGVLDQLSTAGQNLISAATAQANTSTVNDPALATEDAVTTAEAEAELNAFEDRELEPFIKPICDLFLEAFELNRGNNWLRGRAVVVVLHQLLGGTIERKVRDSARSLFQDDSLLRYLTLARDNLFPDGVLRKFESRSMQERLKSRAEATVVLATLLPDLAGNVVGRANAQAAARRIFATLNNRPLNTHLAFTVLDEIVLVLFGGGGSRESGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ38</accession>
    <name>A0A1Q5TQ38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_7110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="58410" checksum="0BFC120C5031F959" modified="2017-04-12" version="1">MADNILSSTSLWQNRKCLFLCCLVSMANMQYGFDLAAVGSLQAMPGFLKVFGHPDPGSDTGYAIDSTVQQLITSLLTLGSFISSLVAGLFSTYLGRKPALWLACIVNAIACGIQIGTSTPGVLYLGRLLLGFANGFLVTFSNIYTAEVAPAHMRGVMVALFAYWVNIGSIMGAVVDNKTKERLDELSYRIPLACLYVVPTLLFVALFFVPESPRWLLHRGKEGEARRALEQLRGESYKRILVERGNGSGDEGSGSVVPTLLEVEWVEMIKGVDEEKREQGSVSALDMFRGPDLRRTLLCYGMIGCQTASGVWFLIGYQTYFFTVCGIIKAFEFSIMNTCFGFLGVNVGMYAISELLGRRSILMLGAVACGLCQLATAIAATVSPNTLPTGQTLVAFTALFMFFYNGCVGAASYPVATELVSSRLRAWTVGTATSLGYLLAWLVNFCTPYFINPDHLNWGARYGYIWAASNLCCVVFFYFFMPEMKGRSLEELDEIFAARVPARKFNSYQTVIRVAARIEAANAKDASQRLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQG1</accession>
    <name>A0A1Q5TQG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 4-demethylwyosine synthase (AdoMet-dependent)</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_6997</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQG1"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="127"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="435"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP02464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="784" mass="87984" checksum="2ABB7675C60F224A" modified="2017-04-12" version="1">MASMPTTTDGLLAAWHTYRLPLLIALCTLFVALRAYRKVQSRSKTPTSSSIPSSPRSLSPEKSPIPRVPTEKQPPLSIPTNNGKLAPNDEPPKSTSGPKRVQGKKPAKTVSGRRVNNEESHPLSIQPVIFFASLTTTTERYANVLLEDLRAAAQERADLEKREYGLLPPQIHDISYIDFDDFFAAAPKPPSTSPGTRYLYCILIPTYNIDTVLNMLLGHLDEIHNDFRIDTAPLSQLAGYSVFGFGDKEEWPTEEEGFCSQAKEVDRWMAKLTGRKRAYPLGMGDVKSDAETSLKEWSRGLQDTIFDILESGGLGEGVPGSGDAVESDEEDLGDLEDMDDESRSKKKTTSTMVDLEDIQMNGDSAGPIPIDFTTVGKAVSAEPTAKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFDGVKEGHYKKIKMLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHVERISSFLVCNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHIQRTVFRLTLVKGFNVEDEVIGYANLVEKALPGLVEIKGVTFCGTSTSAGAGLTMKNVPFYEEVSAFVVALNEELQRRGLKYGIAAEHAHSCCVLLASERFNVNGKWHTRIDYDRFFELLEKEKEDGTSFRPEDYMRETEEWALWGRGGFNPDDERVFRKGRDANSRARKAQEILGTAITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUC6</accession>
    <name>A0A1Q5TUC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUC6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12998" checksum="5A5F6C1A59D2F4D5" modified="2017-04-12" version="1" fragment="single">MKTQVVPSPQWENHWKTAKTLKGFENTDGVSCYRNAILQMLFHLPVFLNWVHLCVKAHVDDQGDCPNGRDLDTTEDEDTRCKLCRLHDLLDAFWDPTSDKEDFGVAVDDFWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXJ9</accession>
    <name>A0A1Q5TXJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDP-mannose transporter</fullName>
            <shortName evidence="8">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXJ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXJ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP04958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="10770" checksum="9344B9391F9F39C8" modified="2017-04-12" version="1">MQLLLNQAPISTGLLMCLAPVVDTPPTATTLSPSVCVAIIGSGLLACLVNVSQFYVINAVGPVSSTVVGHVKSCMIVGLGWAVSDRSMSMQSCIGIIMAFLGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXL8</accession>
    <name>A0A1Q5TXL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXL8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP04985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="532" mass="59506" checksum="AE4A554070295ED5" modified="2017-04-12" version="1">METEKSPVPNVIVDELAQQAKLANDVEHQSTVWQAIKGNFWAIFWSLMVSMCVVMEGYDTILLGNFYAYPQFAKKFGTFIPSDNSYQLTAAWQAGLSNGSGVGAFFGAIMNGALVDRFGQKPVLLSSLVSLSGFLFIVFFATNKPTLLVGEILCGFPWGVFATTGPAYASEVLPMALRPYLTSWTNMCFIIGQLIAAGVLAGLVGVDSEWSYRVPFALQWVWPAFLIPILFFAPESPWHLVRKGRLDDARKSLERLQNPRATVSVDATLALMVLTNKDEQEELQVETSYWQLFRGVDRRRTEIACISFAGQITSGLVFAYNSVYFFQQVGLSTKQTYDLNVGGNALALLGTIVSWVAVMPYLGRRTIYLWGMLTMSIILYIIGILNVWTTHSSVGLAQAVLTLIWTFVFQLSVGQLGWSLPAEVGSTRLRQKTVVVARDTYYITSVISSVLNPYLLNPTAWNVKGYTGFVYGTTSLLTFIWAFFRLPETRNRTFEELNQLFSKKIPARHFQEYEVNVFETESSDKQTVLHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U030</accession>
    <name>A0A1Q5U030_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U030"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U030"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP05833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14881" checksum="BEBF7B07375342C9" modified="2017-04-12" version="1">MSTTRRKGRNRSSQDSSGEDTEKASPSAPPAPIPKDPNLVERNGPNDPENPQNFAPAKKWLITVLFSSMTMWVTFSSSIFSAAVEVIAKEYNVSNEVTTLGTSLTLLVDASLQSYQHPKIVRGHALMCTSLCRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1X8</accession>
    <name>A0A1Q5U1X8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAGA-associated factor 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1X8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1X8"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000055">
        <property type="entry name" value="SAGA complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="324" mass="36078" checksum="2745482ED2FD2205" modified="2017-04-12" version="1">MSRNRPRPRDNGLGNNEEMELWTRICQDIRKSKEKFDQQASLSVQIKTLVEKITREGNKPTMSEHDQLDTWLRQSQKLSEEERSIMQDEPCDVIKNLELLTALRKASEAEAPPNRSSALSKSRKKRSEIESSATDSPSASGVDKTSRSKGGVPRSTSVSSNQARDGRSEAVVVKIEEGSEGTKGTMAERSGLLVVGALVVFKHSKNKQGVEGEGIQCIIKNISGDGHKKRWYDVQDPEPNENGEEGAVFKTTASSLIPIPHAGAPLPSFPVGKQVLARYPDTTTFYRAEVMGSKKDTYRLKFEGEEDDKEMETERRFVLDIPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Y4</accession>
    <name>A0A1Q5U1Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Y4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1Y4"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="80"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="32510" checksum="3803A135E69C7EAB" modified="2017-04-12" version="1">MLRRQTRERRDYLYRRALQLRDASIAEKRAQLKASLASGKPLDPSIANDKSLRENFKYDESKDEVDVDDEYALTSGLIDPRPLVTTSRSPSARLGAFAKEIRLLLPTSIRLNRGNLVMPDLVSSATSASLTDMILLHEHRGTPTALTVSHLPHGPTASFSLHNVVLRADIPNADRGTVSESYPHLIFEGFTTKLGQRVVQILKHLFPPREAGKVGTRVVSFVNKEDSIEVRHHVFVKSSYRDVELAEVGPRMTMRLFEIRGGTMEKGSTGDVEWALTQYTRTSRKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U299</accession>
    <name>A0A1Q5U299_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000595">
        <property type="protein sequence ID" value="OKP06606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U299"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="496"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1502" mass="168732" checksum="0C24FD20350CB804" modified="2017-04-12" version="1">MNRHDRQQHTPRDLKIYQYNVHRSKDVVMAQFLREEEVISADIIAIQEPWENPFQDNTHHPLKQTHDLLHPAASETGDRARVCMFVSKRVEHTYLAHSRDCQEIRVKTELGELRIVNVYNDQQQGAALRLLQEKLLPIREQKGASYLVLGDFNLHHPTWGGDDAPRDVGAEDLLDLMETAGLDNWLTPGTVTRDQAGHQSTIDLVLASYSLREQMVACEVDESVHADSDHLPILTLLEINVPEATDPVKRRNWKATDVEKFLTFASANLSAMRLPEEPKPREIDYAVNHLLDIVQQAAQASTPWAKPSAWARQGWTPECTEAIEASRRHFRQYTRTHSEEDWKEFTLVRNAKGRVIKKALKQGFRQWVRDTIDKGPRGLWKVSKWARMRDQSTSSNIPSLRGQDDGLAETNQEKVNLLRQVFFPSPPVADLSDIEGSAGITNQIAFPPISLQEVRDAIQRAPPDKAPGEDGIPNRVWKLLADNDHFVAILTAIFDACMRTGHNPRHFQASITVTLRKGGPRDYRQPKSYRPVALLNTLGKVLESIVATRIAWAVEEYGLLPKTHLGGRKGISVDHAIQLILDRVHRAWGRGKKVSMLLLDVAGAYDNVSHERLLSNIKRLRLGQFVPWIASFLSDRNTRIKLPGYLSDSFPTPTGIPQGSPISPILFLLFNSPLLSACSTDRRIGEAKSCGIGWVDDVAILVESESYYSNVQAMERVLKKADQWARQHAAKFAPDKFELIHFNNPHQGDITNQHDNQDNNQENDQGNDQENNTIDIYDFDGAHPQGSNQMPVRINDELSIQPTQSAKYLGVWLDEQLDFTTHRKKLLAKANSSLEALRAMTGSVWGASLTAMRKVYQAVVVPQMLYGVSAWYCPAARAMPAGELRRTINEFTKIQRRAAILISGAFKSTSAAALNVELFITPVHLLKDQIIQETAIRIQTGAEWAQPDCLRRRQQRSPQEIRKGGWGPLEALRWKKDGILGPKGSVWESRKAFVLAPWEARIPCVIDQDAEAARAAHDKIESLQQAALDRTPTVSQDQTILFFTDGSGYEGQVGASAVAPREGVFQRRYLGTTDESTVYVAELNGIEMAIARFVNQYQHATQPAKMVIFSDCQAAIQAVQNPKRSSGQFVLTCIYDYVRALRSLQRAPTFDQIPIEIRWIPAHVGVPGNETADVEAKLAATGGVXNGAEQPHPEGSAGRVLLAATAKRRVRRRIKERWAQEWAKERTGKPNQRLVKAPDKKVLRLFESLSKPYTSVLIQMRSMRIALNHFLYKIKAVESDECQFAPWIASFLRNRSTRIKLPGYLSDSFPTPTGIPQGSPISPILFLLFNAPLITACGLRTGIAQSAGFGWVDDVAVLVESESYYNNTITLEKILGKANRWARRHAARFAPDKFELIHFTNLNENEIAQGPAANDTTHIGSDIFDYATQHPEGNDQMPVQYNELSIQPTQSAKYLGVWLDKHLDFDTHRRKLLDKANGSLEALRAMTGLVWGASLSAMRKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8Z5</accession>
    <name>A0A1Q5U8Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8Z5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="9379" checksum="5209435E1F382CD6" modified="2017-04-12" version="1">MDADLQTPYYINPASPLMLLHRNYMFFVRDDTLPEKTSATEIHHYGLVYTHFPIIRWKDRLDNAYFAARIAHHRDANSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA03</accession>
    <name>A0A1Q5UA03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kelch repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA03"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA03"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39322" checksum="2B2ED2B9943A94A7" modified="2017-04-12" version="1">MHWVNNTVPAVKYQALWESRDNSTLWMYGGLFVGNSTSDGVSTNDCIWQYSPGSQTWQMQQQTLTPQRLVHGDSTKNYVSGMIQLNTTTGEYVALSAPFTPVQEGALTYIPNAWNYVQIYDIAGGKWYNQSTTGTAPSRTQFCAVVQRDEASPTSYLSILSFKRYKASSLNTGRITLDCAAYGSQIFGVGGRLAWADDSGAGCYDMPAFIYDAQSQTVKAEFDSPYPSSWADPGLGNLFLVDQNSTSSTNSTASKINNSHTSNKRAIAGGVVGGLVGLALIMALIYYARQHARKKRVESEDLKIPPRTKIGELEDSVKWSELRTKTNTRTELHERFVERYEFQDNPVRRYELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA56</accession>
    <name>A0A1Q5UA56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000533">
        <property type="protein sequence ID" value="OKP09358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA56"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="361" mass="38631" checksum="461A72CFE8403C24" modified="2017-04-12" version="1">MCLLNLPSELLLVVADFLEAEGNINSLAQTNHYTYSLLNPYLYRRNSLRSGSSALLWAARHGIEATARMCLSERANVGAIDGVARTPLSHAAGNGHDRVVSLLIANGRVDIDAKDDFNITPLSEAAFGGHEGVVRLLLATGKVDVNAKDSEGWSPLTCAARKGHEEVVRLLLATEGVNIDAKDSEGRSPLSHAARKGRTGVVRLFLATRGVNVDAKDSEGRSPLSRAARKGHEEVVRLLLATGRVDVNAKDSEGCRPLSYAARKGHEEVVRLLLATEGVNIDAKDSEGRSPLSHAARKGHAGVVRLLLATEGVNVDAKDSEGFSSLSRAARNGHEAVVGLLLATGWVRRLRAVIGSFLEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAR4</accession>
    <name>A0A1Q5UAR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000500">
        <property type="protein sequence ID" value="OKP09551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAR4"/>
    <dbReference type="OrthoDB" id="5064334at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34610" checksum="6A2720EE5C580140" modified="2017-04-12" version="1">MTFSQSSSATPAPLDSAWPPAHIWETMGAADRASWLGQIQRDRARRLELDVAETDLRRRRPRVDQQDDDNLEENREPPPEVKPLIDIFPGVSAALLTRVFERKLKATELIRFKEKSVTELDQEDRVFKMTESGGTVGFKKAAASLKDWGPNPQIWTTCFVAYLAVVGYLFGEKHPKAVPNLLMFMRQILDFAQTYQWLEAVLPLALNFHQYILDKGELSTDNYLITGPFREKYLRHNLTLPAKSPTNPPTRPRQARNTRSSNNETEVCDKFNTTGCSWEGCKRRHECTACGLSEHGASSCRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC57</accession>
    <name>A0A1Q5UC57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase MuDR plant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC57"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC57"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004332">
        <property type="entry name" value="Transposase_MuDR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03108">
        <property type="entry name" value="DBD_Tnp_Mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase MuDR plant" evidence="2">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="392" mass="42333" checksum="B6585C15E4F2350A" modified="2017-04-12" version="1">MTEMYSGLHAGQRFSSLEEFKTVIRSISVRQHWELRVIRSNKKSVVIGCRSSANCYFRVVCRSNKNATYITSLQDSHSCRRSADSPAATPARSEASHVRFLLSEIPKLFDMKSRIKGQDVVDAVKRYHGYDISMRQAQRALTKLQPRQADMQGENTLDMDMSTGEQSPGPSLAESPGEPGPSYRDISETRWLPDHLPPSLMDEASVNAAGSPDPVAAPPLQPPQTAHSVRPPQIPQPASIGTPSQTALSNDTRPIISQQGVGYTTATPLSVAPPEHPKPPGYAQRNDHPGVPQMVLTNFKIEFTCTTCGSLNQSFFPNQGNVTGPGYMGHHAMHEQAAVPRHPGAAPSNAPDGSNNEVPEDGGYTVNALNARVMQNAWATGGLGVPIGPANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCJ6</accession>
    <name>A0A1Q5UCJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCJ6"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270863" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="126" mass="13191" checksum="40939E9B988B1703" modified="2017-04-12" version="1">MQYSKILALATLFISTTIAAPLAERACAYTCGSVCYTSSAVSAAQAGGYKLHEAGTTDNSYPHVYNNYEGFDFPVSGTYYEFPILSSGKVYTGGSPGADRVVFNGNDELAGVITHTGASGNNFVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCL9</accession>
    <name>A0A1Q5UCL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCL9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCL9"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="610" mass="67856" checksum="1734753B62242668" modified="2017-04-12" version="1">MPPDSQAEQPHYVEPNELLPRDYNWTYDQDPGTCDIFTADSFHLNGSGFHAGGLIHPQSLDTSDLCFLENTYDATNTAPAIPFMGHELGNDSFPASVSSLDGFSDMMNVYSGTTSPGNGLLQDTPNTQLLDGFSWNWESSPGVSDPIPASEPIEQPAPASLSQQRPAPAPRTRSGLPRRRSRYLVSQPVQRTPPIQVPGAKEMDPMQRWQESPPEDEPASLTAIMNAMDEMPNNRSPGQAHGTRPTNAFKHYRQSASITSGEFSASSADSACSSAGRSTPQSSRSRRSKGRVAKNKAKPWNDTKPRIFCCTFCCDRFRSKYDWVRHEKSLHLNLETWYCAPQGPSVFSETTGQEHCAYCNAPNPSREHLIEEHSYEECQNLSKASRSFRRKDHLVQHLRHVHQVNTVPLIDEWKSESKNITSRCGFCDQKLLDWDERIEHIGDHFRSGLTMKDWKGDHGFPPSITAQLRNAFPPYLIGTESESMIPFSSTNAAVRDHYAQMSARVEASKGYGNTGQESAAAGAGAGAGAADATKLQFDNFLGNFTRHLGQFARQQMQNGVIPTDEMFQQEARRVVFDCGDEWDQTIADNPQWLSSFRRLHCENGEDGSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCT3</accession>
    <name>A0A1Q5UCT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000370">
        <property type="protein sequence ID" value="OKP10269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCT3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCT3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="403" mass="44336" checksum="C3D3E6785937EA38" modified="2017-04-12" version="1">MVAPGLGTYANPIVIGDDLAPLGSASNPIVIQVDEGWCQDEPDQLGSDADTEIMATPEFWGTLTAGHLAVPVKDDVALDSSSVRVPTRSLVCEDPEGFQPFGRSSPNGFQSEKALKITKHSFDALRECPGFGATRRENVASDHRENTLPSNSNRSKQLQGQSEEGRVTMRFYAPDFQKGATWPTNLLVNQVIIRTAFSPDIPCSLEIFKQDDILFGRGAVVVPMEGKDPKCFLTFSPKARQDDHGTNVRASRKRADGIVILESVVPEREKGANWRYGFTGQVSVEIYKRWPPLASDYEEREVFFGSIALIIHSDGVDPKCFVTFSSGLSSADRKPHSPAGNVVCEPSMTTETFSRETVDQADTSVGKNLPLNSHSRSLKRQLSHDGIQSELRRSKRLARRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCY1</accession>
    <name>A0A1Q5UCY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quinidine resistance protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCY1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCY1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="48551" checksum="41F51F22D396C8C4" modified="2017-04-12" version="1">MAMASCNPNESKLLNDDTSQERSANVHKVEDQEMEGLPCRQHQSLSILSGPEKILSILIITTMTFLGPASTSIYGGLMALRCLQSFGSSSLSVVGIAYLSDILTRAERSKYRLYTSSGYTLSHLVGPVTGGLLAQFLGWRYVFWFLAIFAAVTILFILVFLRESCRAVVHNGEVPPQRWNRALIDFLHPLEYRQDTPWPRTPGRTPGRTPGVLDTIRLLSHRSTCLLSIFSAVLFCGNMAIFVSIPVLFEDQYGFQLWQVGLTYVPYAVGGFAARWIVAPLTTKNKRRYRRRIGVEAMDRSPQELPLERACLQVILPFVYMACIWMAVYGWLMKRNVHPAGPLVMLCFAGNAITGVNIGITGLLLATHGKRPAVVLAAANLVRFLCAAGAVAGILPLVKTVGIGWTATIMAGVYLLFSGLLWVVYCYGHLWRTIEQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDI6</accession>
    <name>A0A1Q5UDI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDI6"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="53729" checksum="0DD6C33FE58477D1" modified="2017-04-12" version="1">MAPRYRNIAVIGAGPSGISAVKALHEEKVFEKIRIFERRDKPGGIWHYDPTPDVFPIPQNSPQLRNAIPKKLPQFASPSPEDTTARTGIYDALDSNVGSKAMAFTHRPFPSVNSALSVKQFGHSNPTHPFRTIAGYLEDLFKDYYHLASFNTTVEKVEKQEGKWILTLRQSGHVRNDEPKDYWWQEEFDAVIVASGHYSAPLVPEIPGLENAVSTHPAKFEHSKAYRSQNDYVDQRVVIVGGNVSSADLVVDLHAIVNAPLYLSQRGYNEVLQSAWDLPNVQTKPVISSIQSNSEGVSVKFSDGSEVADLDKIIFATGYKLSYPFLTPDPVTPNNRVAGFYQHVFKIGDPSLALVGQIRAAISFRSYEYQAVAVARYFAGRNAKPLPSPQQQDLWEVERLKYKGPTTLFHEIKPDFKEYFDFLHDFAGPPAKESDANELPAWEDRWAEQAFEVLQLKDKYWKSLKKATDSSSQVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDW7</accession>
    <name>A0A1Q5UDW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11148" checksum="043F94E7E1CF60B3" modified="2017-04-12" version="1">MRPKKVVHIGHSFGSLITNGLVASQPSLSDGIVLTGFSHNTSFTDLLVLCLGYELASTNNPTRFRNYNTGYLTWGDVYDNQCAFYTYPFFDTAILKQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE07</accession>
    <name>A0A1Q5UE07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE07"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="254" mass="26254" checksum="92D05F829452B68C" modified="2017-04-12" version="1">MDAVNKVVNAATAALWGDGSTAQQQTTPHGEEPIAGVQGKGNFNDPFDAGNREEQPQAPPSDGNTAQQEPRLDGAKTDPTRKDLIADIKTDNDVDQEKTSPTAPILAPSTFTSPAFSPVPVTGAAASSSATPAEAGGSRAAVTGEPKTTEHEQRTTESTSGQSSQVPHPAKHHEASEEALKGPQGPAPFCAEDFEKEAKGMKPVKTGGGPVQNGSSKSSEKTSHGNGNGKHSPLHKMKEKLSKVVHPGHGSHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF96</accession>
    <name>A0A1Q5UF96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000297">
        <property type="protein sequence ID" value="OKP11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF96"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="225" mass="25860" checksum="9486594E170F2CA3" modified="2017-04-12" version="1">MQSLHIFDEESDIDDVGPLPPSPRSLLASDRMDGAPVLNLSITGPTTLSLKDYDPSSRLRYAVTAILLYEAAPNISRREPIVFHAFLFKDVDWRQEGFRLYRKENGQWQPYEIRGSFTHHRYRVPNPVSKNVGRNEDNDFIALNPGESWSFTRQVTDFPENVVPGDTFRYCYKGAQLDWWDWGHFQDHEDTVVTIEGKVREPKDNGGRPALVIPASNYVEFTVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFC6</accession>
    <name>A0A1Q5UFC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFC6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010257704" evidence="1">
        <location>
            <begin position="31"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="106"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="457"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="821" mass="85689" checksum="A8B19518DFD76BED" modified="2017-04-12" version="1">MAVGGSEEGGVKMRFAPLLSCLSVIACANAQLLHLPQVEKLVKEALKPLTAYTNYHGPKTGTANSIVQSVVEAATSAAVDPSYWLADISHQGLAAFNSNPSGYKVFRNVKDYGAKGDGVTDDTAAINSAISDGGRFGPASRESSTTTPAIVYFPAGTYLISSSIIDYYFTQLIGNPNSIPVIKATPGFTGLGLIDGDQYQSDGNQGWGSTNVFFRQIRNLKLDLTSIPASSAATGIHWPTGQATSIQNVQIAMSSASGTQHQGIFIENGSGGFLNDITITGGLYGANVGNQQFTMRNIAVSDAVTGISQIWDWSWTYQGLTLTNCTTGLSINNGGAGNQLVGSVNVLDSTIQDCPTFVTTAWASSTSTNGSLILENIALDNVPVAVKGTSGTVLAGTTGTTTISAWGQGHKYTPNGPANFQGSFTAPTRPSALLASGSSRYYTKSKPQYEASPTSLFVSIRSAGAKGDGSTDDTSAIQSAITSAASSGKIVFFDQGTYKVTGTIYIPAGSRIVGEAYPVIMAAGSKFSSITSPVPVIQVGKSGESGSIEWSDMIVSTQGSAPGAVLIEWNLAAASGSGMWDVHTRIGGFTGSQQQVAQCPTTAAVSAACEVAYMSMHITSTASGVYLENVWLWTADHDLDSASNTQISVYSGRGLLVEGKNIWLIGTAVEHHSLYQYQFSGASSVMAGFIQTETPYYQPNPNAANSPYPTNSALNDPSYSSCLGGNCDALGLRVLNSKNINIYGAGLYSFFNNYSTACSTFPTPENCQSMIFSIEGSTSALVVYSLNTVGTTNMIVKDGTSLAVVGDNLATFAATIAYFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFD8</accession>
    <name>A0A1Q5UFD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFD8"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="38"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="420" mass="46495" checksum="703199B0146932D7" modified="2017-04-12" version="1">MVFYPEALQQSLEEAIQKRRDIRRLWTLRPPEFYENGVNFISNDFLSLNSGVHRAEVLKEIERHPNFKVGAAASRVADGSSDYTFKLEQYLADFHNAESCLLFNSGFDANVAIFSILPRPTDIIVHDSEIHASVHTGMRASRASLIKSFEHNDPKSLKKVLLGILENDSAVAKGDRTIFVAIESIYSMDGDIAPAAEIVQVVKECLPLKNAVMVVDEAHSNGIMGPRGSGFICHHGLESEFAIRLHTFGKGINATGAAVLCPPLFKETLVNYARNFIFTTGPAFLTMATVKASYNVISSDEGEARRQRLQARIRQFYGSLTEHHLWGAACKAGRVRVLAAETWKNMEFISPIIPLLTKPGLSHSLEDRLTGCGFFSLEVGYPVVAKEKERVRVIIHADNTETEVDGLVDAVVNWAADLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFE9</accession>
    <name>A0A1Q5UFE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFE9"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="12" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="430"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="682"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="798"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="838"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="920"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1030" mass="113496" checksum="1CC09939E882E812" modified="2017-04-12" version="1">MDEHDHDDAGQGPSSNDTFGQFSFAPATRTTVVTTTTTTTTSFPPLLIKPPRATKDLDARLYPLASTPTPANLRNLRFKLGDQSIVFNEPNDTNAAFTELNEKNDALKSSNGLIRSVNSFITEDDSASRRLTAPRSVARINHPNPQRRPVSPVSIPDPRPTVLPRTRANRVPSEPVARRTRHYASTSTHLSPAGLATPEIEHNIGSLGEGQASKQRVQSANFPRRETLLRSPLSAEVGPSDTGAQKLLEDLAQRPEPQITKSSDANAAVTSNPSSFGQTVSFASTESSSQRRPDLTAQLSAIDNALAQDMCLPSPSLSPVAAMNALHGESSFDSEGPDVDTDSSLDHNVPRYSKAVRLLDTDVSRVRVKSLAAAQTSRSPPSLMDMPKVLEFFDSVPDELKSYMMYQFLRRCPKPTLHFVADVVNPTLKCDFLTMLPLELSLNIVKYFDVQTMCRASQVSKKWRHIVSSDEKTWKDLLDRDGYALSEGELERAIREGWGWQCSSADDFERDLSKQYSARADQESSPVASSSHPQERAPLASLTPNRRPKRKANTRASSRKLAKRKISSSGTDHSEPDWKRDIAASEAPYAAANAAATAIPYPDVGMPTLRGLYLYKALYRRHHAIRRGWMKPEVKPQHLAFRAHDRHVVTCLQFDTDKILTGSDDTNINVYDTKTGALKATLEGHEGGVWALEYHGNTLVSGSTDRSVRVWDIERARCTQVFNGHTSTVRCLQIVLPTEVGKDANGRPEIMPKVPLIITGSRDSNLRVWKLPKPGDPSYYPNGPLADDTDCPYFVRVLSGHSHSVRAIAAHGDTLVSGSYDCTVRVWKISTGQVLHTLQGHSLKVYSVVLDHKRNRCISGAMDHMVKVWSLDDGSLLHNLEGHTSLVGLLSLQSDYLVSAAADSTLRIWDPEHGHCKNMLSAHTGAITCFQHDGQKVISGSDRTLKMWDVSTGACVRDLLTDLSGVWQVKFNDRRCVAAVQRESLTYIEVLDFGAARDGVPENKLGKRIVVNRRGREIATSNVDSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFQ0</accession>
    <name>A0A1Q5UFQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sterol uptake control protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFQ0"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36601" checksum="C9D9AD15FAD04F52" modified="2017-04-12" version="1">MSIPGWRESVLAATLALYGTSEQNPGAIAAAYKWYNHALCYQRQNLRLFIENPSVQVNEMHVSMAVILAYSEVVLPSHTRAFSQHIKAAATLLQIVGPEACMHDNLHQIFLTIRLYMVYESFGERKVSIFASNDWIDVPFQNREKSSLDLVIDLLLQIPGASPRMAATLLEGLWRQLVQSNPDLISSPRHIMLKQVLGFRDLWDCVPDRFRHSSSEAAIALALYNFGWITSLSLLKQCGDHAAEYAELIDSHCGTILDAAAFVSTIEDGCSYIRLTPPLRSVLQYSSNQGQRKSALLFMRAWGKSINLLQLSTGPFGQNWQFHDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGB2</accession>
    <name>A0A1Q5UGB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_3014</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGB2"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="147" mass="16566" checksum="053C2A4F9DA1537C" modified="2017-04-12" version="1">MALKRINKELTDLGRDPPSSCSAGPVGDDLFHWQATIMGPTDSPYSGGVFFLTIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRPRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGE4</accession>
    <name>A0A1Q5UGE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">beta-glucosidase</fullName>
            <ecNumber evidence="4 12">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 12"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGE4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGE4"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="14">
        <location>
            <begin position="751"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="828" mass="90925" checksum="4B48C4C6FF6ADCE6" modified="2017-04-12" version="1">MNPHAEGWEAAYQKAHGFVSQLTILEKINLTTGVGWENGPCVGNTGSIPRLGFKGFCAQDSPQGVRFADYASAFTSSQMAAATFDRSILYQRGRAMAQEHKGKGITIQLGPVAGPLGRTPEGGRNWEGFSPDPVLTGIAMAETIKGMQDTGVIACAKHYIGNEQEHFRQVGEAAGHGYTISDSISSNINDRAMHELYLWPFADAVRAGVGSFMCSYSQINNSYGCQNSQTLNKLLKSELGFQGFVMSDWGAHHSGVSSALAGLDMSMPGDTQFDSGLSFWGSNLTVAILNGTVPEWRLDDMAMRIMAAYFKVGLTIEDQPDVNFNAWTHDTYGFKYAYSKEDYEQVNWHVDVRADHNKLIRETAAKGTVLLKNNFNALPLKQPKFVAVVGEDAGPNPKGPNGCADRGCDQGTLAMGWGSGSTEFPYLVTPDSAIQAKVLEYGGRYESIFDNYDDKAISSLVSQPDATCIVFGNADSGEGYITVDNNWGDRNNLTLWQNADQVIRTVSSLCNNTIVVLHSVGPVLLNDLYEHPNITAIVWAGMPGEESGNALVDILWGKVNPAGRSPFTWAKSRKDYGTDIMYEPNNGQGAPQQDFTEGIYLDYRHFDKAGIEPIYEFGYGLSYTTFKYSDLRVVKKHVRPYSPTTGTTTQAPTIGQPPSGDLNTYKFPAGFKYIRSFIYPYLNSTLSLRAASEDPEYGRTDFIPPHARDGSPQPLNPAGDQVSSGGNSMLYEELYEITAKITNTGHVAGDEVVQLYVDLGGDNPPRQLRDFDRIHLLPGQSSTFRATLTRRDLSNWDVKAQNWRVSDSPKRVYVGRSSRDLPLTSRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGF0</accession>
    <name>A0A1Q5UGF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="53355" checksum="ABB8B85CD68DCEDE" modified="2017-04-12" version="1">MAGFNPFRARNPDGSSAGATTSPSIPDNVSLDIFTKPASSVPTQLPNGYPKKPSLSLELETDDSTSSDEQTADPFNPDSSVSDTDNEPGHDGNIQRRSSTSSALDDRPREFFGSSPHPAPSADGSTATPSFNLPFVPTTTQTIRSGSEIRLGSGSSTLQEIVPPPVTRDGGQTQTSRSPPEPGTNTSPPSRANKEKKPPPPPRSHHGKRISTSTNATANTRVNAASSSSHTSPPRSTNRLSYHASSPESQISTRRAGTPNASSTSQATGADYFSFSVSSEDQQRARAPHSSYPAESVQRSASQHSQHKRPPTPPLSRRHSQMRRSKSIQSKSSGSRLTMSSRDSESTDSSGPPSPGPSTRSVASSISDRKRLSMPPPSSSRSREREAEPRPAPGHSLSPDSLSPPPTTTRSNPPPPDRRASSHGSILSGGSLASAAPPPPPPPRRARDSTSRSGEGRPVSQVLGVEEAPLPQPSNAQDILADLTRLQKEVDDLRGHYESRKVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGN8</accession>
    <name>A0A1Q5UGN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGN8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGN8"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="58865" checksum="87E73F746D959272" modified="2017-04-12" version="1">MAAGDKVSINAPSLGANIVGSLDQENNVALFRGIPFASVNKRWTHSETLHSLDNDFDATKLGHRCSQLSGMVLVSGGTNDPLPGDDEFKCLNLNVAVPKEALYAPDSKPLPVMVWIHGGGFAFGANSVARYRPQALLVHARKCGTPIILVSINYRLGALGFSASKDLAEEVNGGSRTHPMGNYGFVDQRNALEWVNEHIQDFGGDPSNITVFGVSAGSVSIHLHLLAEHALFDRAIMMSGSAPVLSPKEPETYQRDWDRLCDKTGIKASTAAERLEQLRSLDVDVILKQATPAAMGPVADGKLLKSGWTYEENVSNKRCKEFILGDTNVEAIIFDGLLKRLSQARFHELVDEAFSVEDAEQLYLKFGFTREPQSEEDFRKAFRLLVGNTLFNYSHVGIAKASKNSDAWKDKVYLYHFEQPSPFPGPTHGLSYHGLCAMLMHLNELPNCPPPTQEVSLEAARIWTAFAHGQQPWEPYSQNGKFMRFGPDGKSDVYDFESDTTRDYKFQTWLGEHIGEVGSFVGRLVMNLENNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGV6</accession>
    <name>A0A1Q5UGV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGV6"/>
    <dbReference type="OrthoDB" id="4322309at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="21822" checksum="752D9BEA012B781C" modified="2017-04-12" version="1">MSTPATFSSRREENIHLFVESRRENCDKLLGWKSQLLRTPGIRRELSNSLEDIMLCDWDEFTLLHDAIREDWSEADDADHNGWDNCWWTEGLGIQAVMEALIWDLHDRPAYYHYAELAEILNILSVCIGQLQYQKEIDDHVRQMRDAAQQMNRRRRYFGPRLGALCDELFEIMQCECQYCGADES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHP4</accession>
    <name>A0A1Q5UHP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000253">
        <property type="protein sequence ID" value="OKP12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHP4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHP4"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="257" mass="27675" checksum="4FBFACB7945D378A" modified="2017-04-12" version="1">MAVENTPIYVFVPGAWHTPDTFDGIRALLSKRGHDSEAIVLPSVGAAEPTKSGLHADIAHTNGVLRALADQGRQIIVVMHSYGGMVGAGAAEGLVYAQRSKAGQLGGVIMMVWLAAFVTPRGKSVIDMLGGNWLPWMLLSDPDDGYCHSSQQETVFYHDMTPEAQQTAISKLKPHAKPSFLEPATFEPWNEVPSMYLYCDKDAALPLFVQESFAQILGNPVTFHVDASHSGFLSKPEETADGLELGLKAGLEKSGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHP9</accession>
    <name>A0A1Q5UHP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_2376</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UHP9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1828"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2091"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="460"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1554"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2217" mass="245778" checksum="0E4A97D04A6A89F4" modified="2017-04-12" version="1">MDKLNRLVAYTWDESRQSRSSYGVWHVFGTKHLGRTIRPDYAQIGRLRSASSPGDLSGVSVPQGADEDSNSNDGEDRGKESERTIEVVARIGDNMIQEERLQEEYQTLASAAASHRKYLLRPVEMQRLSSHDEEHEPSLLVCIYESPGPNDLLRFVEGGAPIWNHTRPEGEESDIETDVGLNRSDRREPMPLDAFLDFAIGAAECIEMLHSQQIVHGQIRGDAFHFSQETGRVRLIHLGAGLRAYDIGRLTAGSHSLASISLMSREQTGWTPIQPDSRADIYSLGALLWSALVQEGSYGSKTPLDIIREVLGQELPSVSTLRPDVPELLARVIAKATAKNAVERYNSVSGLRHDLVKVRRLLTSGDKAETENWEIASKDVSPFFTLPRTMVGRTSERDAIVEVLDRTSRMYGLRLSSVPEDQFAMFAAPPSSGDNLGGKEGHTQAEGLTSARIAQSYIANSSRLRSSRDSQYSSSEGSEFGPAVFDGKGVEKRLSTPSIGSSSGDGSSRSGDDAGRTAAHRLMALKGRCEVISIEGGAGMGKTRLITSVQIEARRRGFFASSRFDQATQDRQRPVLQLFSSLFEQAFSQSTIEPSFLPMLRNLIGPAWDTLHKVLGLPKFLLGSGPDVPEQVLNHAARSTKSLPYRRPPENTGTESSKEFLRTGSSTKSLPLVRTLLDILRAFGQYKPVCLCLDDVHLADEESLELITQIVSAGIRMVLILAYRSENASPEMTKQILQLSTNKELRKGRDIGVTVVKLSPLSEDSVMQYVASTLCLPVPVILPLGALIQSRTSGNPFYVREMLNDCYEHGFFSYDYQEGQWSFDLSRISEHFKRDNYNDSIFDDFLIRRLSSLSPVSKSILAWASDLGMTFSFQLVKKLLSNDETDAESGLSEREMIQGLQATIQAYVIVPTQDHDVFSFTYHHYMHLAASFHTKDQDHVNFVKAQVLFRYYAHDDKYRNMLASAIIDSTPILRASMATRGPFRKFLFDYAKAASETGFRSTAIKSLTSCIQLLQEDMWNEDAEDVMYDETLQIFTSAAEGYLYQGEHAEASRLLESMLSNARSPVDKAPSWILQSRMLAQLGNSSGAFQALKRCLMTLDITIDDDPTFSKCDKEYRRLCEAISAMTTEDIVEKAFVGHPVLAAVGAVLVEATSAAFWSDTLTFYQMTLVMVETYLARGPFPQAGMGLLQLAVIAITRDNAIAFASHCSELALALIEQSNDPRTRGRGIVLYSTFVDHLQHHVQSSISQLEGALDFSIHAGDRIATILNYGLLATMKFFASENLAELESFCVYSCQDITSWQSDTPGGTILITIGQLCRALQGKTYTNDGTRVMSDEEHDTAAYKYWLVKTIKNSDRPLMLYESMEIAPLFLYGHYERAVALGNSCLKKVNAIWSTRNTRFLMFFHSLSLAGFVWMRKQQQLDPEATLEEMGNMARMLKYFRRKIDQWQVVTDVNYLAWTKILDAQIAEMERDQRAALCFYQEALDHASMHGFAFEEALASHLLAEHLMREGSARLGTLALKDAASLYRRIGATGVADHILHLYGLEEKAKSLPREAATQTESDESVTRSRHQASELGNDEQSSAGETVAERTLHVLDLTSILERSQVISSVLRVDELLRTMCKVIMESCQGTATLAAIITKENPAVEWAVAASCDAAGHIKVRHPPTPIGRSLVAESVVNYCVRFREPAYLPDILQDPRFGYVSEAWVAQNPASKSVVAFPISHGGDESEPLAVLYLEGPPNAFSYLNRVVLQLLVVQLGISYSNALTLKEVERVSALNQSMVHVQKKALAEAMAAEQKANTAKAEALHHAQLAEDAAKAKSSFLANISHELRTPLNGVIGNSELLLSSPLPEQQLGMADSIHMSAKLLLTVINDILDFSKIEANKVQLHIDSFDVGKMIQEVVRSMSTDFRKEHQSKVVRIIQDIQLPQFLVYGDPVRLQQILGNLIGNSLKFTEEGSITIGSRVEEETDDSARLSFWVTDTGIGIPPHIIQHLFKPFTQADASTARRFGGSGLGLSICKSLVDLMGGTIELKSVEDVGTTVSFSITLPKVNARGSGTTSPTASVDGSQLDKAEPIYQDLSQIPVCKLRICIAEDNLINQKITVQYLKKLGFTQVDAYNNGLEAVEGIQKKARAEQPYHVVLMDVQMPVMDGYVATRRLRQDSMDAVRRILIIALTASAIQGDREKCLDSGMNDYLAKPFLLAALRKKFEKYLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHR5</accession>
    <name>A0A1Q5UHR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000253">
        <property type="protein sequence ID" value="OKP12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHR5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHR5"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="181"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="542" mass="60459" checksum="9CDB82F0218D9AE8" modified="2017-04-12" version="1">MLRTLVDNQESCKLPSKNGNDLQQSLNWDDILNQDLFSNQFGISPPLGYSVPKEQCPRSHQVQLPLLQYKDETAKQILLELLPSQEDAISIASHTTAWAMELPNPPGAIWKLGDGSPVRDLSAAAQFSTMGIAKAILYFALSIQQLPPGFKTSHLQMDDVDYHVRRYTQVVGTLVLAHEEMSCSTEGLECLLLLGMIHINEGDLKQAWMKFRRALDVARLQGFHKSYEPSVRQSQSPELAFHRRLWLSSVMGDSFCSLILGFETGATQPFGPDYSWDDPFADENANFQRRLCIVSAQLSQRNLVGLQNSIDEAKSINTAIDGLQNSMPDSWWQRPDLREEQSLNCAQEYDRLLSHLWFFQLQILANTAFLFSPEAEAEQYRDRCLEAAKTTLYRYLGLRLAGTTRLHCRAAEIAAFVASLALILSLSRSTSPQMSDSSKALNSDVALLDQIIDSLAALGLSSGHEHFALKSAEILTTLLRKLKMGDSEVSAYRGGKRKAGHSAVHHHTTKRQVGLPELLLSSVKSALRNQPNAHILDTDDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI40</accession>
    <name>A0A1Q5UI40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI40"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="419" mass="46725" checksum="6FA62B0801A31D21" modified="2017-04-12" version="1">MESTEIPSPHDPTPQSQEDLCHHGEENDTRQSLQIEETPPADETDAAYQRPDATNTRISFQEEEEKFIPLEETPSGYPELDWKPLVLQNWCLFLATAFFGACMTGLVIIVCLNNIAPEMLHVAQTSSRLAFRYVPAAAGTVTTVWWGSVARSYLRLIPYITMASASTGLSGRAPQGLLTLRSVSNLLAFFPTPAALARLIKERHILTMVTFSTSFLVIPFLTPLKNALFQTTQDPAGWSITVSNKVAYIAITVYSLLMGTTISILVRLWSVRTGLKWEASSIASQLALVQGSNIYEPFYGLEFEDPSHLYRIAGSWHVEYGVLRLGYWMVLRNGEETIWHGVRFYKPEGAITQMIINGRKMLIRSSVVEQPPTPRDEAETPTLEQRGTHEEGGSASPFLGDYNVTFSRNIDGQSTDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIK7</accession>
    <name>A0A1Q5UIK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9400" checksum="3B57B72F0D9905CF" modified="2017-04-12" version="1">MARHEVPVSSVQQVGPENETISELSSSLQVSSDGGFSHAAKDWSANFDARPSPQLLVSVIHRSKELIQQIDHIFDHGCRNTFSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ17</accession>
    <name>A0A1Q5UJ17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiolase-like protein type 1 additional C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="383"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="51750" checksum="5FDFABA297B6BAA6" modified="2017-04-12" version="1">MSATIPVVIGVGDLKNRSNRLEDAFEPLELMLKAITVALKDTGISTQDGKALQKSIDSISVVANWTWPYPNTPELLANRLGCRATYLRESEHGGNAPAELFDEAARRIASGESKVAIITGGEALASLGAFQAAKKFPPPGWTHVDDTTSIWERRHKSNLASNYGLGLPMQVYPLYEAALRAHRGQSLADNHRESSELYAEYARVAAQNPIAWTHGKEPDTGDTIGKHARQLGVPESQLIFPLGGAGTHDYEHFWERSSFHSSRSLSSCLDATLAVSNVKTEDIDLYDFYSCFPVVPKLASLHLGIPIYGGKRPTTLLGGLTSFGGAGNNYSMHAITEMVRQLRRGNGRIGLVLANGGVLSHHHAVCLSRRPRGDGAPYPNRNPLPRHVSDAQPAIAERANGSARIETYTVQYDRDGSPLAGFVLGRLDENGSRFIAITTDGSTLKDLGSASEQIGKSIWVGSDQETGRNTFKILGSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ26</accession>
    <name>A0A1Q5UJ26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ26"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="57" mass="6182" checksum="940724A655277E32" modified="2017-04-12" version="1">MRTSRLVHNELGLNNHSAIVSPFSPDQPQHYQQRSYSDDAAGVGANARILDGFGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ40</accession>
    <name>A0A1Q5UJ40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transport protein Sec61 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_1874</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ40"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="125" mass="12596" checksum="3697DA443C857D20" modified="2017-04-12" version="1">MASPRPASPLTSGAESGPDSKSAGAVAASGSSISRPSSPTPPGGPRAAMRRRAAADHKESLRNARPASTRSAGAGGSSGTMLKLYTDESPGLRVDPVVVLVLSLGFIFSVVGLHVIAKITRKFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ77</accession>
    <name>A0A1Q5UJ77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_1879</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ77"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000247">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000452">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000459">
        <property type="entry name" value="Multiple RNA-binding domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="305"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="488"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="599"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="704"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="151"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="826" mass="91592" checksum="52C358F35FC03F70" modified="2017-04-12" version="1">MENTRVFVSGLPPTCSNDQLRNHFASRFTVTDAHVLPKRRMGFVGFKSNEAAQEAVNYFNRTYMKMSRISVDLARPIDSKPTERAHPTRKRDAAEDASDNALKRKRDADSKSQDPKLQEYLALMQTSSKTRTWANDDSTAMALAAEQAVAPINPPTQDNIPTEELPSHPKKVRIQEPTADGDAGKPQAMEVDKSDEDAEEDTPAQEDAEAEQDEAGPVSDSDWLRSKTSRLLGLLDEDEQAEFDQHQAAEPAESQSPDMEESRTAVFEDVRPQPVADDAAVEDEDAVETTPERPDPNVDLIRDSARLFVRNLAYDTTDADLQPLFAPFGKLDEIHVAFDTRTETSKGFAYIQYTNADAAIDAYRALDGKHFQGRLLHILPAATKKTYKIDDVELSKLPLKKQKQIKRKMGATSTAFSWNSLYMNADAVMSSVADRLGVSKAELLDPTSSDAAVKQAHAETHVIQETKAFFASNGVNIEAFKGRERGNTAILVKNFSFGVKSAELRSLFEPYGQILRLLMPPSGTIAIVEFARPDQAQAAFKGLAYRKMGDSILFLEKAPKNLFDGTAVPTAVPETQAKSQGFSTSDTFAADEPETGMTSTLFIKNLNFSTTNDKFLEVFRPLDGFVTGRIKTKPDPKRPGQTLSMGFGFAEFRTKAQAQAALAAMNGYKLDQHELVIRASHKGMDAAEERRREDTAKKIAARRTKIIIKNLPFQVTKKDIRSLFSAYGQLRSVRVPQKFDRSARGFGFADFISAREAENAMDALKNTHLLGRRLVLEFANEEAVDPEDEIAKIEKKVGEQVDRVKLQQLTGGGRKKFTVGAEEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJU3</accession>
    <name>A0A1Q5UJU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,4-dichlorophenol 6-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJU3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJU3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF21">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="87"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="488" mass="53982" checksum="B03C9E0531E1A407" modified="2017-04-12" version="1">MDTPMKSSINEPSPSIQPLLAEALVLVVGAGPIGLLVAYQLAKRGISTILIERNHETTRWPKMDITNARSMELLNHIGLADGLRKLESIITNVDTGVEHAVQSQYVIGCDGAGSRVRKSTGINLTGTPLPQRTLLVHFKSSDLEVLHRQGQFWHLFLSKGACVINQDEKDTWTIHITMAPGMDEDTLNPEEMVYAAMGDSGSPQRFKIDKILVTSVWSANLSVADDYLTKSKRVILAGDSAHQNIPFGGYGMNTGLGDAYDLGWKLAMVLHKQGGEKLLDSYEVERRPVAIRNVSKSGINAEVHMKYASWVNAEPAGTIRSETPAGRNLRERLRSHVLTDDGENKNLGIEMGYRHSKSPVIVPDGNPNDEPIWTEKDYFPSTWPGARAPHVYLNDGVTPIFDLLGFDFTLVDFTGDGSVGKEFAVVATRLDIPLSLLHLPNEKHARQIWERDIVLVRPDHHVSWRSNVSQSPNQVEIEDILLVSSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULH9</accession>
    <name>A0A1Q5ULH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULH9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="54941" checksum="CC318788C2D48AD2" modified="2017-04-12" version="1">MSLPLDFLSAAGHEITAHPTPDSRALGSRPVYKNEVPTPPVPSRDDLIPVSPSSPPLEPSPMSPSPHPPIPQLQREYTRRRLLPPAMTDSQLSECSKLFWQSGDNVWYQPDNAYQIFDYKASPTYHCHDFASRITHLELPLHLVDYHVMAITGREFWDRVQELFPSARNVVLSSSSELRGRQHFIIRDPSLFTSELVELAPPNITPFVAMRPPREDNEDEEGLRYRLWQVKAHSWNLIQDTWTPMRVMLPPKKVPCGLLNDFLRSDWLIGIALCEMRAISWLKLETYARYSDRRGFECPDPECKSLKFYNLKEFKKHILKECRGSPLFTRDLDSVLGRTTPEDFKGVLDRDLVVCHRNTPVERKAIIDTKQRRVDKLVSIRNALKDGLRDQYRRPGEAKLQFEEALTAQMKEHGYLTPDEQIWDAYLWTDCDEDLFEFDDSQYPDAKDIDPECPEEECLDRDYAGEEYFEYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULJ4</accession>
    <name>A0A1Q5ULJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="9529" checksum="68AB643994FABF5E" modified="2017-04-12" version="1">MAKERPLTRLAPVYTQWVQIGIMIIIYVFLPESPAWCATRGDGERVKKELLKLNRGVKDYNLEQQYELLILTVEHEKQGAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULX2</accession>
    <name>A0A1Q5ULX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L14-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULX2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULX2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="16802" checksum="9BC3AFF7480E5CB0" modified="2017-04-12" version="1">MADIDVKLASWKLVEVGRLVLIRRGPYAGKLAAVVEIVDHRRVLVDGPSSEEQKIVPRHVLPLAHATLTHFVIPQLPRAAGTGPVKKLWAKNEIDGKWAKSGFAQKTDRTERRKNLTDFERFKVLRLRKQARYEVQKSYAKVKAAAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM21</accession>
    <name>A0A1Q5UM21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM21"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM21"/>
    <dbReference type="OrthoDB" id="4167490at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="40538" checksum="F6E6383A841B366F" modified="2017-04-12" version="1">MGHPDPLAVHHRTSRLESLPVEILQLIFLHSLEINLPRASPRLARALSNPLLYTWLIRLVFSSTNPGSREGFFTPDFLPPPLDFWALEWEERQRLQSSILACRWCTLPLMRRCQREYVDHAIRRKCADLVFSEEDRVLLDSLDGRFDDLGECDKAVDGRRGKGDLVLPAQLPDTERDRSSVSRSFDRKVAIWFHFGAVQIREPNEVYYENDLFRLPCSVVIGPGRIPDKVLQEPWSDAQFEFLQLLSGDFYLDEDEHSAERSVEITTRLIRKRRIEPFRRLLRMSFRAANCRVPACWPLKPDHYHLIRRYGGGGPGDPFAHFILSERWDVIPASAKEDLLRLIEPGQTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMC3</accession>
    <name>A0A1Q5UMC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMC3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="57" mass="5872" checksum="B63696EB45BEBE58" modified="2017-04-12" version="1">MTYSYCVLEYANSTDGCDNALYSGLNVTDSRAVCIGVGSTNMTATSTATATSTETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMI2</accession>
    <name>A0A1Q5UMI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMI2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="32694" checksum="D796DCBAA1BAE04F" modified="2017-04-12" version="1">MQSVEKYANLTIGRASDGPPPPSVGSYLRLARDQTSNGTQIEERRSAKEKEHQFVLRGKALVEKSSFNQPIIRGLRTHTLAALRNPARFVFQVPFGLIWTLYAATYAVANGADTIGTELKATATGMITFLSTTIVNVPLGVWKDLKYAQIFGTQQSPNNVETVRKSLVQNKGVARAATAMFLARDSITIFGSFTLAPRLAEAIPDNLTSHPHAKPVITQLTVPVLTQLVATPLHLFALDLYIRQHHVPLADRIVQSQRYLGSTTVFRCIRIIPAFGFGCLANMELRSTFHKKLEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMR8</accession>
    <name>A0A1Q5UMR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMR8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMR8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="476" mass="53876" checksum="EBA7B1C50F171098" modified="2017-04-12" version="1">MRVGKGCERCRYRHIRCVIPPGASSCAPCARQSRVCQLDPPFHFKNVRQVYQKSSGISARFDLDWDEDQVWVNTSQPVTFVLESCDDVDGDREQHVEETHVQDSHTPENETLTTMRPLSVEPSWYPHNNGGSGILAVEHVSPGAAQSHSNETSPQQQITMGNSLSLSHPTDGPPSLSLREASLMRNFIQKIAPWADICDPQCHFSTGVSRRALQVPMVLKAVMALAARHDAILSNQSDSEASEYHGQCLELLIPALDRPEQTYDENLLVTVVLLRIYEELENTTDPQFHLLGSNRLINLMSRSASSGGLAEAVSWQFLRQAIYASVVQYQPFELDLQNYARSSMFQRSDDAAVANMVIFHCADILRICRTVPQEPVDEDARLQVANAVEEWHRAKPTTWQPLRYQPADVAVNRPFPEIWMMSAPAVGYCLKHWTEHQGSLEFLTCVEKILGWRTSWIKRELERQWTELEQVDSPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNZ1</accession>
    <name>A0A1Q5UNZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_96</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000107">
        <property type="protein sequence ID" value="OKP14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019182">
        <property type="entry name" value="Cytochrome_b-c1_su10_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28254:SF1">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09796">
        <property type="entry name" value="QCR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="10599" checksum="1349FC24185FE816" modified="2017-04-12" version="1">MVAGFTIPSAIQAGTLAASFGVFAGTAALFMFGEVPRVRRDILQQIPGLDTYYDRRIAPEDNSPVINRGWDYIAEKNMVNPIWILGATLLLGYSPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP63</accession>
    <name>A0A1Q5UP63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dedicator of cytokinesis protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_25</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UP63"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="631"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1455"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1792"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1870"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1966"/>
            <end position="2134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2144"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1801"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1872"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1971"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1982"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2064"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2087"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2102"/>
            <end position="2131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2163" mass="239476" checksum="964B8996E355C417" modified="2017-04-12" version="1">MPWRPLPRIAFAVAIYPFHPSSPADLPLELGDELYIIEQGGLDGEWCRGYLVAPPSLLAGLTSTKGLTLEARVFSGIFPRNCVEIREVLGDGEGYKALLNGDRKSVDRLTLPGLSGLEADLVSRSSVAYSVTESQAGGEVSEVVVAKKGKPAQIVIHKIDESDLSNPNSAHTYRTGSIPHTPVTLAPRDPDAPKPAAPVPMLKIGDETPTSLTEPLVDEIASCLREWHSTNLHELLLARQYDVLEEMSTIVQELDFARRQLLHNVLTGKEKESLRDETVWKLVRANKMLSGDTIVRDPEQRGRLLTGEDSAIQLAKLQSEMSMLDSSPVANSDTTALNHLLLEINAVSGNAPGPVSLGIQLYSRSDSGIFNPMSETYSLDIPSPDKFVSLTQSSKLKTLFTELAATDIGDGSPNGRQLYVVASVRAAESRSTVDNIPVSRSSISREGSAASKAAATGGVQPSVKGSLRTRRSMMWAPKTRGSPSLDQTPRSAAPGAPRSSSSSSAPQDPNTPQPTPTKESSAIRTIGVGILEVSPILRQDKDTESVINIWSPPREGEEGEGHPDGFEKLLHTLLPSPSGRYVRADTARLHIHLHPFTSTDPETLVRQNPTILQDVVQTRRIGFSKAPTKPRSDIYVTISQAIFPTDALLSHPTAGQVSLQSTTDLRNLQLTLEVRDASGARVDKCVFPSSANTSHTAWRTTIAERGTPWYQTIRLNIPTEKIPGSHMIMSVADAPEFPFALAWMPLWDQQAFIRDGQHSLLLHAYDKQTSSIENGKGAYLNLPWSALGKNESAKDEAVTGPLATLRLQTHLCSTEYSQDQVILSLLNWKERPVDEVLNTLKRLLFVPEMEIVKQLRGVFDALFGILVENAGNEEYEDLIFNNLVTVLGIVHDRRFNLGPLVDHYADEQFNFPFVTPCLIRSYLRLLNAATDVHQSRNLRAAFKVGRHLLKFIINAREQQKAKEEGIGITSVQSTFNRDLHTIFKSMESLMKNSSPALVGSKTLIVQHFHYWLPELSKVLGRDEMIMIALSFMDSCKDVTGMLVLYKLVLIQSYTQFEIFASGDERQTLISSCVGWLTPYWGSTTSVSDQYRDQVRLSSAIVAQLLTQSHPQLYDFMPSIVASYCAISAEGVDETEYLSLLFSKSFPFQVKVSKTPQRFDEALVELSAIMAAISKIVSPKTPNLNELELATFVGQALEAHNSIIDCEAYPESWFSIHVYNHRAAIKGLEHLALLLIDKLLPDADDADDFDTKLWESFFTTLLKVISSDALALETFPEQKRRAVWKIAGDVREQGADLLHSTWEAIGWDTTDEERERFGLKKLGGYQVQYVPNLVPPIIGLCLSVHEGLRHAAVHILRTMILSEWDLNQDISIIETEIISSLDSLFKVKHMSESVSQKIFIGELLDLFEGDAEFDEDLFNAVKGLIATVDELLDLLVASQSSTSTQSLHALKLMEYMKDMGREDIFIRYVHELADHQSAYDNFTEAGLALQFHADLYDWDVNKPLPELLTPAFPAQTAFERKESLYFSIIQHFENAMAWAPALACYKELAAHYESTTMDFAKLSRAQSSMARIHDFIAKGGKQFPRYFRVVYKGLGFPPSLRDKEFIFEGSPTERMASFVDRMQREHPTAQIMSSSEIPDYEGQFLRISGVTAHRDISHPVYQRSKVPGSVREHLLISDPSRFSATSRRHTSSSDVREQYVEKLIFSTAEPFPNILRRSEIIAVKEIALSPLQTAIERTWRKTQELQLLERRAASGEDNGLSNLTEALEQLLETRSSPTNCVAVYRAFLSGAQGTKESKNEETAETEDDDDEMDDEEETPETMDPMENALAVALIDHALAIKHALSLYQRPAQQATQAELLRRFEAVFEPELASLSTTPPEYSSPTPTQPARRTPSSETRRKQAVQRSVSPEQELIRASRGNTHHRKRPERQSVSHRISIINPFKRSHGASNSIFTIQQSPEKALNALNGTGDLEETPEDDTATIHSRATSQSRGGKSDKRRSWFGGDKIKHGSSPSVAAVGEEMIHGTSLKKRPSRSDTAAQSHDGRSRAGSQHRGGPAATGAVGSPSERPAPPASSGGWSTIPSTRDYSRPVTRDSAHTSRDQAGSLNGGTSRASVSAQQPVNGAHNNNGMRDSVFRRFSLLKGVGRKTSRMDFKANGTLQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPS7</accession>
    <name>A0A1Q5UPS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPS7"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="43187" checksum="82A720E0B4BBC90F" modified="2017-04-12" version="1">MADAKKPAVLIIGGLGFIGRHLALHIHENNLASEVRIVDKVLPQLAWLAPEFEEACSKEKFVQADASREQHLPRIFDRANGEQFDYVINCGGETRHSQPDDVYEARSCNLSVTLGKECAKRGIPALVECSTAHVYKSGSSPRKEADKVQPWHKLAKWKLKAADELLKIPGLQYCALRLPHVYGAYNPGYFAMAICLARVHKEMDQDLEFLYTKDVKVNTLHVKDAASALWMAAQWRASKGKLDRTNGSMPAMFKDPAMPIAFNVVDHNDTCQQHVANAMAEVFDLKVSFLGSLASQLAKLNLDDVVDDMNEVSLQEWADLVSKSKIERPGPIGPFLELDVLKDQDMSIDGSLFESTTGWKPKYEHFGADSVREMVESYKRMNWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPX0</accession>
    <name>A0A1Q5UPX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000082">
        <property type="protein sequence ID" value="OKP14516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="18416" checksum="5F74F78250492271" modified="2017-04-12" version="1" fragment="single">LTYTRVDYLCDLGEVATARLDKEPGRLSEFLGRHGRRPNAVGRVGDAKQHTALPNGSPAPGERVAADAVERYITLRRGRVLGSLIGDRLLSVVDNICSAGLVHVVNLGGPRHSDDSACACCGGELHGLAADAAARRCDKYPYLTVGFTNLSVAALSNDSPWVEQAVLKEPLIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ60</accession>
    <name>A0A1Q5UQ60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ60"/>
    <dbReference type="OrthoDB" id="4336792at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="193" mass="22465" checksum="64AA74E05E8EDAD9" modified="2017-04-12" version="1">MFGSVKGFEPVGNYAKEKVKNRKFQYGKDVQCSSDLLVAIIILEQAIQELAQLEDQWKEEHQASLKSFSQGEDMAWIQECEEMIMYHRNLGDWVGRILYHLEVRLPRGTLKNSYDKLREDPTWYLRKELVKDCVAKDGQLFELRDLMVENLNDPDPTYLLAMADAYFLPPETPGLKGNVVRMCKQIKKAFKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQL5</accession>
    <name>A0A1Q5UQL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQL5"/>
    <dbReference type="OrthoDB" id="3600083at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="703" mass="73774" checksum="8CC293B0C7042407" modified="2017-04-12" version="1">MSDNAHPGVRSLLAKFENSQSPITSPPSRGRSPVGSDTPGSARQLSKVRASFVTVDGAIQSSPGSPLRKTSGRSDSPGIFGPKINADEIESRRQNNVISPTPGGHGKSYTGILDGVVDEAQPEKAAIATKERKVSDSQRTTAYTDSAAPPEAAPAKKEAPVSSASTITDEKAKTGPKTVTKRPSNVHTAKQNTTAKPSTSSRTGANNGTAKPTSAREVAKERANALAHKPSRPSLNPATKTTTRATRGATPSADAHKPSTGSTVNKARSKSPTRPARLPSSMTAQTQSSNAKHGSAGPATGRAEKPAATLTRKPSTLKSAAGPTGAVRRQPSRPSLPAQTAPERPSSRVSETGAKPVNESFIARMMRPTASSASKTHEKPDMKPLPKSAASKAPRPSMGRPSDRGVAQAKAKPAALKPQSEKSQPARKEAPLKKEEVKAPRQKEESDKENIEDVAAAIPEEPSVTETNDAIIDEPEPEVSAEDVVEDVAEKPAESTVAEAELETSLESIVEPTEPSVEPAATEAAVEVSTEPVSTKAPEGSDHQEETTEDVEVPVEIPAIETTEELREQEEEAPAVNAVEDVPAETPIETNGEEQSSVSQPEPEPPKEEILEAVVEPSEPVVAEDVTIPEEDQTLKAEPEVSQQTEAPASTSIDDAPEITEDTSEAHPSEKIQEPKESIPVVESAASAKSDTVDIDFANLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQR3</accession>
    <name>A0A1Q5UQR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQR3"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="248"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="449" mass="50843" checksum="F88BD933F7ED840F" modified="2017-04-12" version="1">MADGRPHHQAAQPSSNLTNTAYDANSLSHEFEQLMRTKRFNQLHDSSRSRAGSQSPAPSHASHSIPPPSRAPPPPPSLGTEMRPASQPQSSTPALRGLPIMPSPPQDAAGLKFFNLLKGLSVTPTKYENPGLLDEALCTLPLDRLYPEAEEESQIMQAQAASVGGKPEWGYQDCVIRALLKWFKNSFFQFVNNPPCSKCCMPTIAQGMTPPSPDETARGATRVELYRCSEPNCGAYERFPRYSDVWQLLQTRRGRVGEWANCFSMLCRAVGARVRWVWNSEDYVWTEVYSEHQRRWVHVDACEGAWDQPRLYTEGWRRKISYCVAFSIDGATDVTRRYVRNFSKHGSPRNRTSEEVVLWSIHEIRRKRRENMSKTDQRRLIKEDEREERELRGYTASALAAEIQKILPRSLVGRPDDQKHADDREEAASEWLSARGHGHSGPDRSNGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URH0</accession>
    <name>A0A1Q5URH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URH0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="32230" checksum="49AE5E963821125A" modified="2017-04-12" version="1">MEQNSSTDTDSDPSTQTCIKCGLGKPIDQFVARTKMKRLTKWCLDCRIYGHALLMWDLAPTAYGHNPPSGDFQPPGSFKILTPPLNPPAMHPAMWGYGPTTPIMESPQRVPSNDFSPRPPAQDRNQASSQASEAEDSSSSSSDDETSSNEGSESGHSAKEMPQKISTEGICSDDEGHGCQHQFDDPDTSDEEEKEIDDLLQEGEPQDLRGEEWADLQRHRESSIAPYFICVACCTARPKRLEDEGICVYCFEHPTQYCVKGGHEDDKISFVDSDGHCHEVCNRCRSNPDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URR5</accession>
    <name>A0A1Q5URR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell pattern formation-associated protein STUA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 10">Cell pattern formation-associated protein stuA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URR5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URR5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="12">
        <location>
            <begin position="131"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="255"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="577"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP15139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="639" mass="68546" checksum="116001CDBDD5FF98" modified="2017-04-12" version="1">MNHSQPYMDVHSHLSSAQPYASQAATAGTMSHYPYQHQPPVLQPASSYAPASYQQYGYSNGVTSPPTGHAPPASSMGGQMPAQLLPLPQVSPVSNHPVAAPSGYGNSTGSPLQGFVYDPTGQIAPPGAKPRVTATLWEDEGSLCYQVEAKGVCVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKLRHVVKIGPMHLKGVWIPFERALEFANKEKITDLLYPLFVHNIGGLLYHPANQTRTNAVVQESNHRRLEGPLSGAQRTTPTAPQHSSLHHHQAMQTPMSSHMSQPPSMGGGPRPSLDRANTFPTPPASASSLMGVTNQGSSYEWGGQVPHTQPLSIDTALSNQRSMPTTPATTPPGNNLHSMPPYQGQTGYDSKPYYSAAPQSHSQYAPQTPMTQSGISNYGQSLPTMNYLKNEMAPPTGRAPETETSDLKSDRYSQSNGSERYSQNNGSGEAGQEHEPEYLQDQGSAYNNRGSYTYTTNPSVGSINGEHSQLTPEMTGSPQQNGSGRMTPRTSVSAPGPHWASGYNTPPRPTAATTLYNAVSDTRGTPAHGASDPYSMASTSTPVYATTMNGNMGSGNKRMREEDDVLRTDSGGEYESKRRKTITETTLGGPVGAPLLQPVKTGGVMARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNN0</accession>
    <name>A0A1Q5SNN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Short-chain dehydrogenase TIC 32, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNN0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13351" checksum="9F7B7565DD3DC468" modified="2017-04-12" version="1">MHNPNFASTNLNYGASKNAAALLLKLMARNVSVDEIHILSFHPGAVLTETARAYGYDENSLPWDDVDIHGHFFVWAASEEAKFLHGRFVYATWDVTELPSAAVRALLDEDSDFLKIGGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNU3</accession>
    <name>A0A1Q5SNU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HC-toxin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNU3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNU3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO89545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="335" mass="37179" checksum="A94FB0B3625F17C0" modified="2017-04-12" version="1">MKTIQDLADNIQMLDANIAFLTPTVAIKANPEAMRNLKILCIGGEPPSKDLLNNWARSSTKLINQFGMGEAAVCCAYNDNVHDPSSSPATIGRPSSGAIWIVDPLCPAKLMPIGAVGEILIEGPHLSRGYLDQDHQASDRTKPAGFMEDIPPWLNELHPNREFTRLYRSGDLARWTYNGRIEYIGRKDTIVKLDGCRIDVVEVEHIARKTLTTKDAIVVDLLGVIDGKEDPCLAAFLYLSGHPENSETEELSLKDASQDPAALQKVVQIKEVLAISLPPYMIPTLFLLATRVPRTPSKKTDRRMIRLLSHKFYAQEREKRSNPPSDHGDSQLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNX1</accession>
    <name>A0A1Q5SNX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">CTP synthase</fullName>
            <ecNumber evidence="3 12">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_13692</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="3 12"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNX1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNX1"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="14">
        <location>
            <begin position="2"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="13">
        <location>
            <begin position="315"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="578" mass="63993" checksum="A8FB200423528591" modified="2017-04-12" version="1">MKYVLVSGGVISGVGKGIIASSTGLLLKSAGLTVTSIKCDPYINIDAGTMSPIEHGEVYVTDDGGEMDLDLGNYERYLLTTLTRDHNITTGKIYQQVIERERVGRYLGKTVQVVPHITNAIQDWIERVAKIPVDESGREPDVCIIELGGTVGDIESAPFIHAISQLQRRAGKGNFAQIHVSYVPVIHDEQKTKPTQRAISDVRSAGLNPDLIACRCELPLEDGTVQKIANMCSMDTKQVIAVHNVSTTYHVPLLLEKQKLIGTLGELLDLPSITRDPLIVDQGKLMWKDWVDLARGQDYPHDTVSIALVGKYTALKDAYISVSKALEHAAMYCHKKLELIWVDAGHLEDEALETNPAEFHKAWHAVCTADGLLVPGGFGTRNTTGMIQAITWARTKKRPFLGVCLGMQLAVIEFARNVMNIDDCGSEELHPQAKNHAIIYMPEVDKDKMGGTMRLGKHASIFQDGTEWSRLRALYGPNVSQISERHRHRYEVNPEMVENIEKAGLAFVGKDDKGERMEVVEIRDHPWFVGVQFHPEYLSRVLAPSRAFLGFFAAAAGCLDEVTESINKGLRSIPNKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRR0</accession>
    <name>A0A1Q5SRR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRR0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO90642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="281" mass="30267" checksum="3147FCC1D57F4DBE" modified="2017-04-12" version="1">MTGYQPNHPPETLGPFHPPKVDKQAIKPSIAQRITIKVTDPLNHSAPAFLHSPRTTPTTTCPPSAVVLVSGAGGGVSGPAGIYPSLADKIALLLSIPCLRLDYREPARTEYCVADMQAAFDYLRDHFGATHFVIVGWSFGGSPCFTVAAREPVRVAGVATIASQTAKTDGVRALSPRPMLLLHGEEDRVPAPSCSKSLFNSYGDDGDREMKLFPGDDHGLTRHAVQVEGKLFGFVVKCLGLSEGLGYEVLWQAGRDLVEGKEGRVKEMEMGRDLEGGERLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSF7</accession>
    <name>A0A1Q5SSF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSF7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9169" checksum="082C8172142A74D7" modified="2017-04-12" version="1">MVNLYCPRRPFDSDQFSAQKAAKLGVEVKEGSEKDGESTLHMDIINADINIGPDEMFLGHTPDNGAAEKDHITGNKDVKPIGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUB7</accession>
    <name>A0A1Q5SUB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000747">
        <property type="protein sequence ID" value="OKO91465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUB7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="299" mass="32425" checksum="92F9A39872239419" modified="2017-04-12" version="1">MASGIYAQSQYTSTGTAAVAQAAATALTLSPTSSVAGLTFDRFVQIWLENEDYSAAIKDTNLAYLASQGISLTNYYAITHPSQPNYVAAVGGSTFGIADDNTHYISSSTKTIVDLLENAGVSWSLYQEDMPYSGFEASYRNQKTGANDYVRKHNPLMSYNSVTSNTDRLAKSKNFTMFNEDLNNNKLPQWMFITPNMTNDGHDSSLAAAGAWSRNFLTPLLSNKNFNTDRTLIILTFDEGLTTGTNKIYAVLLGGVISSAKAGTTDGTAYNHYSLLKTVETNWGLGNLGENDVDATAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV59</accession>
    <name>A0A1Q5SV59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV59"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="54915" checksum="BAE8C288F1619AA3" modified="2017-04-12" version="1">MSAPDATPTAPAPDAPDAPDIHPVVRTALRISLSAKEYRALYSLVGKRAPGVQRKLISPSQYDAIAHSKNRRNEAAVRASLRVFVGTGAALKLVETIISRIRKTTEQKKVRTPLLRSPNFRLSLSLSLVLLLHRLLYRFLVRIRANLCTDDAKPFRERNPRVARALTSRFSPAVGASVAGFALGICPQDQLRLTVAIYTGTRSLEFLYNVMDSKGWLDNRPWWFGSWLLMPVSCAQLFHAFVFDRENTPKWFGNVILRLSPSYIPGRPEALPEGVSWPEKDQILDSLASIASLRWPVPSCNTAFVHHILLSVPPLARFLTAVSLALTIPKLKTVLAQPITSINSLSKRIITMTAVLSAAVGSAWGSVCLLNNTLPRSTLPTKRFFLSGALGGLPFALLANSRSVFMYFFRAAVDSAWKTGVKHGLWKGGRAVELWLFVLSWALMGSILEAHPSAVQGRGLRKALAWLRGDGFVDLEEVEKRKARRALKKADAEAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWH4</accession>
    <name>A0A1Q5SWH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWH4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO92236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="43848" checksum="413D0B048FD78679" modified="2017-04-12" version="1">MAVLPPTVHQIQPPAGSEIDFGAHIEGIDLENISGAHIYRHNPIILTNNPLDEQFEIIRNTLYHHHVVVFKNQHKLSPKAQYELTKRFDPAADNYGHGKTIDAKRSILHPDLKTVPHQPQVQIIGNGFVESYEGLENFQLRHPHHRTFHKDQIPDDKDYDFTRFYRWHIDAALYDLNPPQVTTLLAVQVPKGRRQTLLYDDGSGETMDVPLGTTAFVSGERMFELLSPAEQEFVRTSKIEYAPHPYIWMSPAHSRSTGLGLHSEGLELPPSDLPPIDSTKIKILPMLWKNPVTGKLSLQIHPSAICRIHLADGSVIDDLERVREIVYKLQRPGISPQYVYAHDWEEGDLVLFNNRGVLHSVVGAFKPDEVRLFRQCNLAASESPVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXG0</accession>
    <name>A0A1Q5SXG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXG0"/>
    <dbReference type="OrthoDB" id="4777991at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012818516" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="32718" checksum="2098C26D140D1B73" modified="2017-04-12" version="1">MVKFAKQLGVSLLLLFSAVVAEEAVADEPQQLYNASMHVPQEGILSTRDLFGLEARAYTCRAGYSECAYDTSRCCPTGNSCCGTGYCADPGDTCCNGGGTCPSGWNCCGDACSPVDGECCNGGYYCRAGKHCRIYNGAKVCCASSGCAGESDSGSLGGTVTAGATVTATTTSRTTSTRTRTYADYEYYSTTYYWTFYFYFWTSFAPYTVQTVTSTLTTTTTILSVYVTDRADASSSFSSSISAFTASPPYSATSLKSSTSPVPIHTGASAPTGSTSSNQGGNRPGGANAASVVAADIKVILTGTILAALVGGLALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T070</accession>
    <name>A0A1Q5T070_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T070"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T070"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10530" checksum="0DBC88254749AE7C" modified="2017-04-12" version="1">MQIAVSSSARNELVGFGVAIEKQPPRYRKLKLKTVSVTLGARAEQNPFSVELAAMAYALDMVVGQKDYRITLLTSNKAAALTLRNPRQQSGQGFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0F1</accession>
    <name>A0A1Q5T0F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumigaclavine A dimethylallyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0F1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF3">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="377" mass="42486" checksum="DF9C5CBE268AB4DA" modified="2017-04-12" version="1">MTFTASPPLEQSKTTQPWKVLSQFLPPQSIDHQLWWNKLAPVIGSSLSRARYGIDAQYQSLLLVQSAIIPALGPFQNHDSSNMTWTDCMANSMGPLDVSVNYQNDSKCAFRITIEPVGPYAGTDSDPVNEIAAKQLLQTLSHIQQGIDFSWFDHFEPMLITNREARQHWHAISHLPCKSQTVVGIDLHEDHFTVKPYLSPLLNAAATGGDFLQTMFNKLRALSSTKLNLSVVEEYLSLRKDSVLAEKTYLSFDCKSHRESRIKIYTAMDITSLEEVRDLWTLGGRLSGPDIDNGFDIVSKMWNMIYPKPLSGGQLRQSLTVNFNWELSPKDGSVAPKAYFLVDRDLDENVSSALVSLFKDLGWKNHIETHLTLEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0P2</accession>
    <name>A0A1Q5T0P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein SUPPRESSOR OF FRI 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0P2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0P2"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="429" mass="45432" checksum="A24C03BC7387C947" modified="2017-04-12" version="1">MGKKRRGPTLDELMARPWCYYCERDFDDLKILTLHQKAKHFKCERCGRRLNTAGGLSVHMSQVHKEQLTEIENALPNRSGLDVEIFGMEGVPDDVLQAHQQRVAAQFHQAEAERQAVTGNPPAGSGAGGQPNKKPKLEDFSDLKARLAAHRAKRAEAAAGGSSGEATPLGAGQTVSTPTTYGQPPATASPVHQQQPPVSLTYPPPYGGAAVPATAPYQHQAASPVYPSFSPPGAAPYAPSPVAAAPYAPAYSPQPYLQPAAPMGYGVTPPPFPQQHTPPTDTGLPPRPGSLPTLAGLPQRPAFAAPPINAQQMQQMHMGHPAPPAPAPGYSNGNATQTPGGVSSSVDDLISSAAKEAAAAEKPAKKDKAKNTRMIYSDENVSPEEKMAKLARYAFSRQMFQQETALGEIPGSIVVGTIRDQDKVIDPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T169</accession>
    <name>A0A1Q5T169_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T169"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T169"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="26130" checksum="719BE2A999CC43BF" modified="2017-04-12" version="1">MATRKRRAEIASAGSPADVDDIDLTSAPVPADPDEHICKIPDSQRLFISLTGKAFERALLSKLDWFSYLRVITLALTGYRPDAIRLIGETIMQPRGLTGLAQDTLETSIPEFRSIFTTLATDTSYPILIHCTQGKDRTGIIILLALLLAGVRMDAVADDYARSELELVPEFEERMREIRVLGLGEEYTRCPPDYVPDMIGFLERRYGGVRGYLERIGIDAGMQDLIRQKLLVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1S8</accession>
    <name>A0A1Q5T1S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000721">
        <property type="protein sequence ID" value="OKO94065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1S8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1S8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="210"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="37347" checksum="A6BA26F5CC92E2B9" modified="2017-04-12" version="1">MELAMFCELFAQLRETTAARCASTREFVDRVRLLVHRLNAIAPGSIGDRAHIAILLTQIGPEYILVVDAIQNDKDPVNPTTIGNRLANAEQTVQRKDAATVPHGAIGSSSSTSINTVQKTAKKCNYCKKRGHVVAQCWKKQREQQEQQQPRGHALKAERSASGSPRNNLQTIPLNQVEERQGPPTSKRPRINIVRARVTTLYTHAPSPRWILDSAATSHICWDRSCFINLRPHCEMLDTAGDPVEAEGIGIVKLTLRGKFNHPLVLKNVYFALRIGMNLISVPKLLRNCYSVVAHLQNVFVQRRGQTVGTAYYTEEDLLILRCYISPRSRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T207</accession>
    <name>A0A1Q5T207_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-regulated transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T207"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T207"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="465" mass="50228" checksum="85D94A66419B63C6" modified="2017-04-12" version="1">MQNAQPWQDAGVGSTDLKRALSAISDIPESLLRAELQRRNVGRASDPAGEAPACGSGQRGVYNTPLHVMALFLILVLSTFACSFPVLARRFPGLPIPRRFLFISRHFGTGVLIATAFVHLLPTAFVSLTDPCLPRFWSRTYRAMAGFVAMIAVFAVVLVEMFFAMKGAGHVHANDYDTLMGDIGRDSMDDFQHQDSSYAHLGARGPSSNILMEGLRQDEHGDAERASGSSHDFERSPLSGAHPDKEDEENADIEGLDPYADDVPINGQPQQPSGPHQRHRARATPNFRNQDDLASPMQNPQRQLLQCLLLEAGILFHSIFIGMALSVATGTSFVVLLVAISFHQTFEGFALGARIASLIPDLFSPTSAKPWLMCLAYGTTTPIGQAIGLVLHNLYDPASTTGLLMVGITNAISSGLLLFAGLVELLAEDFLSESSYQTLKGRRRVEACISVACGALLMAFVGAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2R9</accession>
    <name>A0A1Q5T2R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2R9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2R9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO94533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="248" mass="26853" checksum="CAAE164CB921C77F" modified="2017-04-12" version="1">MVSQHGVQGVLGEGESELFVIRRRREGANIHRPDGIHVDMQHLKSGEVNMAINFKDGVILGADSRTTTGAYIANRVTDKLTQVHDTIWCCRSGSAADTQAVADIVSYHLNMYGVVNNEAPSTQVAASLFQELCYENKDSLSAGIIIAGYDPRHGGQVYSIPLGGSLHKQSFAIGGSGSTYIYGYTDANWKENMTEAEGIDFVRNSLQEAIKWDGSSGGVIRMVVLTKKGAVRHLYLPDTNYTGPGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4D4</accession>
    <name>A0A1Q5T4D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4D4"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="47307" checksum="9E0B629B407C371B" modified="2017-04-12" version="1">MILSRRAVLFIGFSFSCILFFTARKLSRPWSSYPQAVGLGDYYGTDYSAHGHNWTGAFNFTSHGSKSLYAPQPNFVPGIPKPPGSTYTKMLVVPRTKKEDTSWIATELPDWGTAIYVADDPKAPLHPPKNKGHEVMIYLSFIIDFYDNLPDVAVFMHSHQNAWHNEELFGGDAAEILRRLSMERVIREGYMNTRCAFGPGCPAWMHPGAVEEDETKQEEVMLARAWGELFPDQPVPSVLSQPCCAQFALSRDRIRTIPRARFIFYRDWLLQTDLSDYIAGRIWEYLWQYVFTGKPVVCVEESICLCDGYGFCFGSPEKYQEWRDMDSERKDLQQRLDDLIYWAEDLRMAQAAGELDETMDLDLPPLGQQSEIEKEVIGMETKVADTLQAAIERGKNPKYRALEAGRPWKEGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5W6</accession>
    <name>A0A1Q5T5W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5W6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5W6"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="619" mass="68774" checksum="3F8C818EB394BFC7" modified="2017-04-12" version="1">MFAAPGSPDVLTLATFAYQVYDTYKGAPKRFKDLTDDIKGLEVLLRSLGNRLTLQQVDTTGQEKSQETLLSSDEATDLEQLVKQAGKLLEELQQKQGYASAPRGLSRFRWSQGEVDSVRSRITSLCAIIGAFNSGLLPRIVSTVPMVEKRQENLAKLDNFLPSANKNSRLSTVSVVDPNTATLTEVENEVIPEWANRGRMLEYYVSEAEAEQNQDPILRQTAHASEPLVSPPVKRSPTTDSLMGNTGALLGLGVHKEEIEVISAIYGPRIVTDIIRNITNAHSCLKMTRVVFSATNETFGGDPWPNCIKAFSMVWRKVIRLDYGNLYSAPQKLFAEEGELLTIDLSIPLPFHKSSATRKRGSIYILNASWHNIDVTEHVASITAKDPRPDIIASNHEFFVEDPCYGYEKIMSVTWTYSDIAAALSYCEVRAVTENSSIQIPPYLDIICANWGGLDITNLVRAKITPQQTLHFDTKNGGAFASPDPLPGWQKTISILYRYGSLEPMQLLVTGDDSGYVMIDPGKRIRRNFFFSNTIEVTSDIRIVAAVWGLQPVSEKRFSTAVTERKMVSCSNDFFGWDGWGGTLKTLQVFLQNVHTGECTCVSAKEGSVLKMPTVWPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T637</accession>
    <name>A0A1Q5T637_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T637"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T637"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="842" mass="95529" checksum="A278D540E0D862C6" modified="2017-04-12" version="1">MPPPNRSPSSPSLRDPPKQALDELFLSRPSMSHPKPSPYHASVRRFSTRRLRPSVASIADIFVGSLVLAGFCNEHTPRHRHLSTISMRTSETQLHRFRGKVVTSHGHGQLSAGKRWECMRSSIPSSRARSWLSTALLPVEEHSHAQDYTKSTQLKQQRGNDDTRPGSREAAGEASHRQNWPQMLDSIIDSENAAGHAKDLSPITLSADSELLSTPEGETGLSYDEKMHRMNSNLYRRILGDDYEWSEPMDVVFPKDGVHPKREAKEVTNEVGLHRLSVAKLIHVLSHEKSPSTSYLFRLYRDIPAPGVAKLPKRIRGQLLRLFAKAPNRRWADARRYLALVQDMIASEKSMSRSMWTSAVHFASRGSGSGRVLKRDLIRAIGVWQQMEHVAGIEADDVVFNILYDTAIKASQFTVADRLEQEMKRRKLDFTRFGLVAKIYSAGVQKDLDGITENFRRFVKAGDLVDTVVLNSLCSAFIRAGDPSAAEQLYARMIDAQAAKLSADRSLTTDSNRVVFEHSLSSELSKYRTNSRAFGDFLKRSQVLKRQFPEHHQALQDSIPMTPDTRTFYIFLRYYARQSGQFDKFVMILRDMENAFDVPPHQIVYMMLFEGFAIHGLQKKAWSAERLRLVWHAYLRALRTSKARLDAQQRHRSPRKMEWENPLANALHLEDELDQTVTETSDEFYMHLPSASNGTQPDSRPQSGKSDEHFEHHMDDDYDDVVNVAPEGSWKPQADADTVKADHEVAGGKMSVSALGQLNPISIGMHQPDDLDKYLENGVFVGRKMIVIILRAFGACYGPKEVMEAWLQLERLWHPHHRKAADVLAVKEELDKQLSRGPRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T718</accession>
    <name>A0A1Q5T718_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T718"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="215" mass="24010" checksum="46550EDB79787CB6" modified="2017-04-12" version="1">MIRLEATFHFSATFNFGTKPSYKVSACPSTFPKSAYLGPTFCSTLLAQSSPYPARSPNYRLPNPRVLFYTVGFCLRTLCNLSSHRHSLRILRDPACYQDLIQFQARCLRAIPITYSAVRLQQRSSRARVVAFSDRTHDCVDAIRSSENWDGAALTDSLSVQLQCPCLAANPRVRSVAIVDTDGFLDMSDADFDAAGKNREDLLLEAEENRARVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8C6</accession>
    <name>A0A1Q5T8C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_10659</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8C6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8C6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO96484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="404" mass="42923" checksum="718490490EA88DBC" modified="2017-04-12" version="1">MPICIECSYPVSHLYSAYSRADDRSQGKGVRLTQCPRCQRFADKYVEYDFVVIFIDLVLIKPQRSIVRLGILLLLFDVYLTWARLEKDPSLATTFIARAPIVVQYLFFLTLNAAATLAHHLTVRLLASMLVPQSHRYGAPETSTNQPATTATTGDTTPFPSGPPTPTIRPSPPSQANHAAQQLFSLGLPAAKLTPNPLFPNDTTSPPDPSMTTQSQQALPPQGPPPPLRRTSTAPIQNIQPLPPPTAASPTAISTALLVSSCAKLFPILLVIWGADGSGSGSGITSITASESTFRKDIGASKAALSSSARDAASSPALLESYLAAAEVSLRPYLPTQYVSGLFDLLASLLSLGVVDAHLVLLSNIEALYILLGCGYLRSVVVAVAGQVARWAVQRVILGAVGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAJ1</accession>
    <name>A0A1Q5TAJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAJ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="96" mass="10554" checksum="7939C5A191A463D8" modified="2017-04-12" version="1">MVPTAPLAFTDSKGEWMSQNSHGSEQKPLNRLSDVLDDVVQNVNRCRGPKVAQTGGDDVLLGGNGPLLYHQTERSKILEMSIFLQETATKPLKMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB07</accession>
    <name>A0A1Q5TB07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_10240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB07"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO97446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="14280" checksum="60A42A270A671405" modified="2017-04-12" version="1">MPQDMPPTGGYAQVQYKRNLPARGFKPFYYMVGMHMIMAYGFYKYFHGVREQRELAREKMWGRLYLTPLLQAEEDRDQVRRYYADKAREKELLGSEQKVYNSDRFVRPTFAYTPSKVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB59</accession>
    <name>A0A1Q5TB59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB59"/>
    <dbReference type="OrthoDB" id="4367311at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012615006" evidence="1">
        <location>
            <begin position="18"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="317" mass="30510" checksum="E33E92C1738312DB" modified="2017-04-12" version="1">MKSFAITAAILASTVAALPTNIIPGAASGVLPSGIPTCLPSGIIPAGLPIPSGIPTCLPSAGAAPGANAGVDNSQVSTDQVTSQVTGQVHSVLTVTDQASKMVLVELEPSVAGLLSGLNLGSVTQSVGQIIQVAPTVGALNLNGATGGLLTVATGEGSVALVKLTSTVEGLLAGLGLPEVGSLVGSLVGTLEGVASGVTGNMKRDALSNVMSITDLSGNPILVQVEPTVLNLLGGLDLSNVQGTVGTVVAEVPAVSGLAAAAQGVAADPTQLFGVLGQDGTSALLVKVEGTATGLLSLLGLSSLTSTIGSVVPAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCK7</accession>
    <name>A0A1Q5TCK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_9875</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886121" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="15">
        <location>
            <begin position="388"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO97949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="520" mass="54058" checksum="10AC637891401ACE" modified="2017-04-12" version="1">MSKLFGSLLVAALAVGVIASPVAEPAITEAPSLAKRATSCTFSGSSGAASASKSQSSCSTIILSSVAVPSGTTLDLSDLPDDTTVIFEGETTWGYEEWSGPLLQISGTGITIKGASGAYLNPDGARWWDGEGSNGGVTKPKFFYAHDLISSTITDLYIENTPVQAVSINGCDGLTITDMTINNEAGDTAGGHNTDGFDIGSSTNVVITGANVYNQDDCVAVNSGTDITFSGGVCSGGHGLSIGSVGGRSDNVVDTVTFKNCEVKNSVNGIRIKATEGDTGSITGVTYSEITLASISKYGILIEQNYDGGDLKGTPTSGIPITDLTVENISGVDAVASSGYDVVIVCGSSGCSDWTWSSVDVTGGTTYSGCENVPSVASWFGEVDSRGFIHIGVIKPHVSEGHYDLVGPDGDIKIISIWEHVVVLGISITLHMWPLPEQTEEQGLEDEERKATGEAAAHSAPELVVPEGFFGFPYSASTAEDTQSLYLAFFIIRLDENIQTAQLNAFCDMDLTMDGEAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCM9</accession>
    <name>A0A1Q5TCM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCM9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCM9"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012095403" evidence="6">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="70"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="507" mass="54898" checksum="2F3054AB8EF3B443" modified="2017-04-12" version="1">MYHFKMQAAMAIAAWAFTTVGQNLPLGRDRLHSRGSYDMTELQSKLSSTAKVYYPNSTEFDTASARWSLLDEPKVNVVVVPGTENDVAEAVQFANQRGLPFLAYTGAHGSLTTLGKMDQGIEIYMTQLDTVTVAGDGQTATIGGGAMSKAVVDALWNVGKQAVTGTCECVSILGPGLGGGHGWLQGHHGLVADQFVSMNVVLANGTLTKIDAHSDLWWAMKGAGHNFGIVTSLTTKVFDIQHRDWAIETITFSGDKVGAVYQAANDYLLKNGTQPEGLINWSYWLNNPGADPNSPVIIFYIIQEGVTTVDSAYTEPFHNIGPISIQPASGTYTDLAGWTGIANSSPPCQKGALANPRFPIYLQSYNVDAQKKAYSVFANAVRGASTFNNSIFMFEGYSMEGVQAIASDSSAFAFRSENILAAPLINYLPAGSTLDTKVANLGNQLRDILRDGTGQDDFRAYVNYAYGDETLQELYGSESWRQSRLHALKQKYDPTGKFSFYAPIPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCX4</accession>
    <name>A0A1Q5TCX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Formate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCX4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCX4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35101" checksum="A1C799ACECFF2915" modified="2017-04-12" version="1">MTFDSFSPLEVIEAVGNTGVHKGNMRLDKVFFSAVSAGCLLSFACGTVLSTNASPWFQENAAGLIRTISALVFPYGLCMIILTGADLCTGSFMFTTVAALQRRLPWWKMLVHWLVTFLGNLAGSLFLVAIIFGYGEVFSKDPFKSAVISFATKKQVTPDFHMIFLRGIGCNWLVCLGCFFGLQGRDLASKIIGIWWPIFAFVSLGFDHVVANMTFIPLGIWLNAPGISVGLYIWKGIIPTLIGNILGGGLFCGEYPICNNSNATHFAKQRSGTYYWYMYLLDLNTLPITGLSKKTDSPTRPATKGDVEAAAADASPASTVLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEX3</accession>
    <name>A0A1Q5TEX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEX3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEX3"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="25604" checksum="7A88DFABEC99174D" modified="2017-04-12" version="1">MSVRSIFTGRMGLSTAGAVARTSQIGSQGASAQLARLHSTAVRPSCAIQNQDLRPHVRASTLSQSRPAGLRAQSTSAGAKDEVKLDWDSFFKLRASRRRYSLSSSIISSLVSTSVGVQVLSSQDLESLGAQVMGLDPFVVLGMATAACGAIGWLVGPAVGNGVWGLVYRRYKPSVATKEKEFFDRIKRFRVDPSTNSIANPVPDYYGEKIGSVQGYRQWLKDQRAYNRKRRNFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF73</accession>
    <name>A0A1Q5TF73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8768</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="409" mass="45239" checksum="1F218BAC74B03369" modified="2017-04-12" version="1">MGDVAVENPANNVTPLPKPAALDALASLDSLEGTGADGNDEYANLKRLQRHLESLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGESEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYRQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVNGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFEQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTIASKMSLSPEVDLDSLIVRNEPLSGAVIAAIMQEAGLRAVRKNRYNIIQTDLEDAYAAQVKSGHEDDRILSVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGA6</accession>
    <name>A0A1Q5TGA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGA6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGA6"/>
    <dbReference type="OrthoDB" id="5383967at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012343769" evidence="1">
        <location>
            <begin position="19"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="496" mass="52797" checksum="8C66DF961353DA83" modified="2017-04-12" version="1">MLPITALAALALLPAIQAAPATSTSPQSVYKRCGPVSQYYNQKASDWDTYKTGDWLNNWWNHNTDLINKNTAGFAGAFGQWAIGNPDWTCRDDGSSSDCDLNLCDNRVLNDRGNDIRPSYYVLESVNRLHSYFTGVGQAFSTAALGAALSKDEWATTFYKDKDDKDATVLKEVLNAVVTVIGIGASFAGLGGGQVVGAFAGAGAALAGGANAAAGIVLGTHKDDTFQKSADLGAILGSIVVDSLKSFTTANNQLMGGKSYNNADIRSYISHGAFLDFPGVDKNTVTDSMTSMLIGTAINSLYRRQKIFIMGGGACNDNQGIGSGPQQAVVCRDGKAWYLYYWQENDVISTTSHQWGWVASPPGADKLGSNEYASVTVQDIINSSLDAYNVAGYNYNADTARARAEDAISNAWASPGAKGAAWEGIFTVPVCDVGNAVGADYEDKQYILQPYGHDSRPVWCGAICGGDLQKTKDFIHAANMDGFKSPKHLCKSAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGE9</accession>
    <name>A0A1Q5TGE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGE9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="56834" checksum="64A51554A5BB9399" modified="2017-04-12" version="1">MRSWYGRGKSLQVAVTACCLMAFILFGYDQGVFSGIVTNEDWRKQFGYPNDSEEGIIVSCYNLGCLLGCLINFFIGEYLGRRKTIWLAMGVVIVGAVLQTSAFTVPHLIIGRLVTGAGTGLKTSTVPMYQAEMCDGKTRGRLISSEVLFTAVGIVVAYWFDYGMSFVGGPIAWRLPIAMQMVFAIFVIILVFGLPESPRWLMNHNQEKEAMEVLCALYDKEENEEYIVNERRAILSAIELENNANKKSVWKMFRNDEVKTGQRVLLAWGMQLMNQVGGINLVVYYVPTVLKNNVGLTGQLPQILGGCIQIMFMLGSLLPAFMLDRMGRRRTMMIGSFGLGICMLMVAALLSQVDKPNGENYASASVSFFFLYMLIHGMSINSVPWVYVPEILPLDARSKGTAIGVSSNWLWNFTVVMITPVIINRIQWKAYLIFMITNFIFIPVVYIFYPETSNLRLEDIDLIFSRGGDPVQQARLMAAEIKTHGYLRSEEMGHEKDADIVKVEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGN6</accession>
    <name>A0A1Q5TGN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoketolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF1">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="497"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="80075" checksum="4D7D65ECE5FB3C64" modified="2017-04-12" version="1">MPGEVIDRPNPEALPSQLPGCVAELQVSLSYQTLDEKTCNALLKFRRAASYIAAGLHINGETPGAIHEGGELGYALSVSFGAVMDNPDLIVTCIVGDGEAETGPTATSWHGIKYIDPKESGAVLPILHLNGFKISERTIFGCMDHKELAALFSGYGYQVRFVEDLKDIDTDLHYSMAWAVDEIQKIQKAARSGNPILKPRWPMLILRTPKGWSGPKELNGEFIEGSFHSHQVPLPKAKSDQGQLDILQQWLAGYKPKELFKENGDVIDEIKSVIPENDEKKLGQRIEAYNKYTPPVLPDWKKFCGNQGANESAMKAIGRLIKDVMKENPDSVRLFCPDELESNKLDAVFETTGRNFQWDEFSNARGGRVIEVLSEHMCQGFMQGYTLTGRVGIFASYESFLGIIHTMMVQYAKFIKMARETKWHCSVSSFNYIETSTWTRQEHNGFSHQNPSFIGSVLKLKPYAARVYLPPDANTFLTTMHHCLKSKNYINLMVGSKQPTPVYLSPEEAENHCRAGASVWKFCSTGDGLDPDVVLVGIGVELMFEVIQAAAILRKRAPALRVRVVNVTDLLILENAGQHPHALATEEFDNLFTADRPIHFNYHGYPMELQGLLFGRPRLDRVSIAGYMEEGSTTTPFDMMLVNRTSRFHVAQAAVRGAARRNERIRIHQQELNSELGHNIVETRKYIIATHEDIDRVVQNEQDDIIASSPPEVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH14</accession>
    <name>A0A1Q5TH14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sterol regulatory element-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH14"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112454" checksum="B27DA93FF29CC19D" modified="2017-04-12" version="1">MDNDFQLFSSRRHSGGDESQAMYSQSEDPSQDWTQWMRWDEPMFTESNQKHMGRALDLPFVSPTTTSSSPGQIHSAEFSPNLPLGLMEIPSGNHTGLNRNGSINGTHSSTIAGHQQLGLVSPISSVGTSRKRKTGSDDDATTVTGPVESGKKMPAKKRAHNVIEKRYRANLNEKIAELRDSVPSLRATRNANGDSNEDDEDADGATPANKLNKASILSKATEYIKHLEIRNKRLEDENTALKNRLRQVDKAADQAVTSSASVSSPSNYTASSDSGTSPSVFSNPEEINETSPTPTNPPEGLIKVPDAFRRMREEGAKSGGIFSQSYIQSTPRASEYGREEGSRRRSKMPNKYMLGALAGLMVLEGFGSDKSESEQKGLLAVPLNLLSRLQLPKIRYIEYYMKSFWSSWHTRAIFHVLLLATLVVGSAFIVFVYLFNAQPITQRPHGKAVTEGKNAPSSSSDFRRQAWLTSMQRVGVPRHRFFREWYVVTSRCFEYVLRCIMGWKLYSWATGITEEDEKGRVKTWDIAIDAQLTGGDIEISKSRLVLTIFAAGTLPRSPMRMMLKALHVRILLWRVGQPGSWTFHVSNDIARALAKYQWAVARDINDALPEGHPDQLPSHLAALLKLDCEDVMIDSIIQRAVNLTWNRPTQEGTADDEVLLDVVEEDPAIQCSVDALAAWWSSHLLQNALLKYLEASEGVPTSKLSRDSFKEKIRMALDAAPRLSAAYTRALVMKAVFFEQGRVQNVSAVLDALPKDKGEKNHAANFLDSSLPVSVRDEISVAVRCAMIAAIVTSRSAGETCLPASFTIHKAINWFNQLPIDPVELSLLGFSAVYHLLHLLASDVDYIASSDSSASSSLVSEAGSSADDEAEEKPRSVGRRLAICPRDIPNLGRVAAELIYWARNAYNPAFYGFSSSLVDIIVKSCTTVCSDAGINVDDYLEAVPEPLPSRRRRHRRRQGGSQQSIQSDADHDAKDPRMGKPLQHERSASNDTGYGSLSLEEEIQSAPNVPEKVLECPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THW0</accession>
    <name>A0A1Q5THW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THW0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THW0"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="148"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="648" mass="73022" checksum="8089C63690FD65A9" modified="2017-04-12" version="1">MARNRPLPLSEEWEDPDTYIKELLNFATTNVLFMNLCGGVHILDFLTREPALYTTLLPEDWRAFFEHHDIHDILQLLLREDIEPLCVEATNGDTSAGARTWKDGAFPPQSLLEYIRQVRQLSLRREFDTSTQKKAKLPRHVAVGMKTKKEHEVEYFSQFVASLSDTVGERRGEPVSHIVDFGSGQNYLGRTLASSPFHKHIIAIERKHQYIAGAMGMDVSAKLREKEKSKTVYVHSRKKSCSGCNGTPEVAASDNAEAQSKTEQHEAPEDVPAQGETADHQEDVTMFKMLGEITLEPHELLGSITKGGQKQKPDHEIDTRGTISYIEHNIQDGYLEPIIDHVVNPSAPTTPSETVTDESTSITIQPEEQQQSNARVMVVSLHSCGNLVHHGVRSLILNPSVVAVAMIGCCYNLMTERLGPATYKLPVLRSLHPRLQATGNSYDPHGFPMSKYFENYESPGAIGMKFNITARMMAVQAPYNWGHDDSERFFARHHFRALLQRIFVDRGVAAKPGIPDDLYAEDEGGESTAAVIIGSLPKRAFESFTAYVRAATTRLLRDPKHASKIQEQIATMTDEEIQRYEMEYLPTKKHLSVVWSLMAFSAQVVEAVIVVDRWQFLREHDSVKECWVEPVFEYSESPRNLVVIGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TID8</accession>
    <name>A0A1Q5TID8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8205</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TID8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TID8"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="65"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="529" mass="57324" checksum="F80D441F9A063052" modified="2017-04-12" version="1">MSSTKFSGTLKELQVTESSVASSPSLSAQDEKHLATPSSDSINLESQIPKPPPYHVFSRSRKIQMVYIVSLAAIFSPLSSNIYFPALGLISKELDVSMSLTTLTVTVYMIVQGLAPSFWGSFSDVIGRRAIFIGTFAVYIIANIALGVSNNYRELMAFRALQAAGSAATISIGAGVIGDITTSAERGSLVGVFGGVRMLGQGIGPVFGGILSQYLGYRSIFWFLAILSGFSLLSILFFLPETLRTVAGNGTVPLHGIYKPWIYCITGQEHAKEGAVPSAEKKKITIKTVVAPLGFLGEKDVFITLFFGAIVYTVWSMVTSSTSDLFESTYGLNTLEVGLTFLGNGFGCMSGSYTIGYLMDFNHKRTEREYCVKHNLPLDTRITTKTHPDFPIEYARMRNTWWITALFIVCTAVYGVSLQTNLAVPVILQYILAYCATAIFTINSALVIDLYPGASASATAVNNLMRCLVGAAGVAAIQPIIDALTAQWAFLLLSGITLLMVPLLAVEMRWGAGWRHERTERLARKNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIW5</accession>
    <name>A0A1Q5TIW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000650">
        <property type="protein sequence ID" value="OKP00146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="33411" checksum="FA97945DCDCFE86F" modified="2017-04-12" version="1" fragment="single">MEKALNIRRWWGLPLPPEIVLELFEYLEPSDVVALAQAAEGFAELAVSAFSSSLREHGRTILFSAVVCGHTSIVKRYLEAGADPCTADDKGNTPLHWATAFGHCNVATLLVDVGADINARHKNGLSPLDYAIITGNDRVVEVLLNKGATITDVRIGRAQRTTLHAVAIKGYSRIAEMLLNRQAPIDANDAHGLTPLHLAVSEGHLEIVRALLCAGATVDIQDEEGDSPLHLAAGNGHIAIVQELLNRGADPSLQGHENATPLHRASLLGFVDVVQCLLEAGAKVSAQSLVGQTPLHQASGAGEEATVRLLLDAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJA8</accession>
    <name>A0A1Q5TJA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Terrelysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJA8"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="144" mass="16477" checksum="897C26BB9400ECA2" modified="2017-04-12" version="1">MTSTPMEELNNYNSQWVSFHIRDHLKDGDITVQNTVIEGGEFHSPTDRRKSLHEDEIDYMTIESDGVGEICARGRRGSEGRLDLFHGDTKICELHWENRGGEFHNLVEVLDDNSKYRIEHGGWSPQAGPLGHVFVDISEKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJJ2</accession>
    <name>A0A1Q5TJJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJJ2"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="29365" checksum="101B6920D8B028F5" modified="2017-04-12" version="1">MRILLHPQLRAALPKSIQRDIRARVWTRFKSQAPRPSRRHESLSPAPKDLITATTRTTSPASAAAKTTVRRGPPERILVYYGGTGRSMFLGILRVTTILLFGGACLIIAPSCYNAENAWYITPLVIAGGAMPMLFVAYTSAPYVSFIHLALPAFARKSRETAIHYAKELPPTTMLILTTTRFNAIPRQTAVRLGDLMPDKSPFRPVTFRNVNPAPRSWWMGRPTAKFFAAGQSQPGRQSTAFYPELWPDIYKRIQSQVAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJT6</accession>
    <name>A0A1Q5TJT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJT6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJT6"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="17556" checksum="D455F3C883437C9A" modified="2017-04-12" version="1">MSKPFDPEQAENLEDMEKQFAVKAVEHLMTYWAILEKVKGSSLRLTKMDDEIYESFKADFPDFDPAATVNEEEMKSKAGKEKWRNWINKFEKKIEDFNFGTIIRTRADVEYDQDTTVFGVRMQFYAIEIARNRAGLNDWIYERSQKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKZ5</accession>
    <name>A0A1Q5TKZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein transport protein SEC61 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKZ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00303">
        <property type="entry name" value="SECYTRNLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP00890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="433" mass="47039" checksum="997415D11F35397C" modified="2017-04-12" version="1">MSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKTDRELYQTAQKLFAIILSFGQACVYVLTGLYGQPSDLGAGICVLLIVQLVVAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIIALFHLLLTWPDKQRALYEAFYRQNLPNVMNLLATLLVFAAVIYLQGFRVEIPVKSARQRGMRGSYPVRLFYTSNMPIMLQSALSSNVFLISQMLYSRFSDNLLVRLLGVWEPREGSAQLYAASGIAYYMSPPLNFKEALLDPIHTAVYIAFMLVACALFSKTWIEVSGSAPRDVAKQLKDQGLVMSGHREQSMYKELKRVIPTAAAFGGACIGALSVASDLLGALGSGTGILLAVTIIYGYFEIAAREGDIGAGLKGLVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLB0</accession>
    <name>A0A1Q5TLB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_7599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLB0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP01018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="485" mass="54417" checksum="324FCA9F1B8485F9" modified="2017-04-12" version="1">MPVANPVRRVAVIGAGPSGLAALKFLLAENHFERIDVFEQRSSVGGAWNYTPSSAKVGVATTVPHLDPHEPAEKPTWIKEADGSSKAVFVSPLYDRLETNIPKELMRYSDQPFPADAQLFPKHRTVQQYLEEYAEATRSHIHFETQVVDVKLNDPKLGTWDVTTTKLHKSQDLTQTYDAVVVASGHFTVPFLPDIPGIEIWNQSYPKTISHSKFYDSPEPFAGKKVVVVGNSASGLDIGAQINGVSAGPVIMSQRSESYLATSAPSDKIICPEIVEFLSPTEHNRAIRFADGRVEENIDAVVFCTGYFYSYPFLSSLNPTVVTHGWRTKHVYQQLFYSEHPTLVFPVLAQRVIPFPMAENQAAVFSRVWSQRLELPSKEEMQAWEVSQVASKGDRKSFHLLPFPMDADYLNFMYTWAALAKPRPGLSNGGHGKLGTFWGERERWIRALFPEIRRAFVQEGDQRGKITTLEELGFIFDDQRVKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMC8</accession>
    <name>A0A1Q5TMC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMC8"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP01380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="453" mass="49117" checksum="87EFE87B01D246B2" modified="2017-04-12" version="1">MHKLSMSTLIRKLHLPASKPGEYTNPKKNLPANCAIIGMETPLHELSLLSAASTGDDTVVSLLLDAGANINEKDITSGKTPLALAVERGHKSTIALLLDSGANLECKDYLSRAPLFYARQPNIAELLLDEGADVDPRDMNGRTPLSVAAEFGDEEIARLLLDHGANPTSKDLLNWTPLTWAFEQNQTHLVKLLLQNGADPEQQDTFGRTLLLVAAETKRESMADVLITQGCNLEVHDHENRTPLLWAAHNEHEETANLLIRKHANLEARDENGRTALLLAAEARHVTMAQVLVISGAILDVQDEYGRTPLLWSVQYGEEGLIRLLLEKGACLEVEDGKYGRTALSWAARRNDVAVVRVLLDFGADIEAEDYSGQTALSVAARAGNGDVVRLLLERGACVEGEDCYGRTAAQWASRGGYSGITRLLGGLGVGRDRDDRLEMGGIASRTVVAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMM6</accession>
    <name>A0A1Q5TMM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_7432</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMM6"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="15"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="431"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP01442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="647" mass="71969" checksum="BE0AA085BDB0582E" modified="2017-04-12" version="1">MASDPILPKEGERNILITSALPYVNNVPHLGNVVGSVLSADVFSRYHKACGRPTLYICGTDEYGTATETKALEEKVTPEELCAKYNKIHQEVYKWFNIGFDHFGRTPTQHHTEISQAVFKRLHENGFLGERTAEQPFCEAHGSFLADRYVEGECPRCHYDDARGDQCDKCGHLLDPFDLINPRCKLDGATPVRRETKHIHLLLDKLQPEVEKWATEAISKGDWPKNSKIITESWLKEGLKDRGITRDLKWGVPVPLEGFENKVLYVWFEACIGYPSITANYTKDWEKWWRNPENVQLYQFLGKDNVPFHSVIFPATQIGTRDKWTMLHHLSATEYLNYESGKFSKSRGIGVFGTNAKETGVGPDVWRYYLLKNRPETGDTQFEWRPFVDANNSELLAKLGNLVNRVIKLVNASFGGIIPEYTVPESFKPFEEEVNGLLKQYIEEMESVHLRAGVNTAMRLAEAGNGLIQANRLDNSLIANEPERAAAVVGSVLNLIHLLASVFAPYMPGTSDSILEQLNAPFLTIPSIEALENGWKADSLKAGHKIGKAAYLFSRIDPKKADEWREAFGGSQAERAKKAEEAAKLAAKKAAAKAKKKEKKEKGKAPGGVEATAKGGAESPSVTADGPNDEAVEKIADGVAQVTLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQE8</accession>
    <name>A0A1Q5TQE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQE8"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="49295" checksum="ADE567D53B7AC106" modified="2017-04-12" version="1">MDEKTSLQDLPWEEAAPASSTASSTPSRSSIRSWILLFSALVASGWFLWPHYCQHTRVHTIEDRVQHILSSTPLIDGHDDFPIQIRALFHNHINTPNFTETFVHGTLPGHVDLPRLRKGHVGGTFWSVYVPCPANWTDFSDENYAPSVRMTVEQVDLMSRIQKAFPEVFSTPPNGTTAMDAFRQGKIISPYGIEGLQSIGNSMAHLRMFYDLGVSYATLTHNCHNKYADAAIVEQPNGSLKIATPLWHGVSPAGQQVVAEMNRLGMIIDLAHVSVDTMRDVLGAGKTEWTGSRAPVIFSHSSAYALCPHPRNVPDDILELVRQRNSIVMVNFSPDFISCQASGRDDGIPNVDYAHATIGRVVDHIIHIGTVAGFDHVGLGSDFDGIPTVPKGLEDVSKFPDLIAELLRRGLTDEQAAKVAGGNLLRVWREIDQVALKMQAEGVLPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRK5</accession>
    <name>A0A1Q5TRK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="9">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_6929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP02857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="572" mass="62528" checksum="487335CA67D92D45" modified="2017-04-12" version="1">MAPKSQSTRMSRKAVSVSLPTWRSNIGYEEGEEWVIGKMQCGYPRFFVHPSIQKLAQEIVRRVGDPESETATLFATLKTARICESFIVSKVSAEEAQKVRIVTFVPSSQAGEGATAVTSSLFAVVYNKEYASIAKQVWQHSGNGISSRRGEFCLRALEDGFLVEEKKSAASESLSQRPCKGPRRYQGKGSISGISRGSSASTPTSTDSPSAANGAEDGRDYAQFIEERFGRNLSTALAAQAKVAVRRRIAGVLTADVELPEALETTSAEGRVSGISEEDVYLYPSGMSAIFNSHQTLLAARGPLKSICFGFPYTDTLKILQKWGPGCLFYGHGSSEDLDDLESRLKNGERFLGLFTEAPGNPLLKTPDLVRIRGLADKYGFAVVVDETISNFLNINVLPHADIVVSSLTKIFSGDSNVMGGSGVLNPQAPFYKLLKDTLNREFEDLYWAEDAVFLERNSRDFISRIDKINATSEEITAMLKASPLVKDVYYPKYSPTRPLYDSLRSPNGGYGGLFSVTFHSTEGSIAFYDTLEVLKGPSLGTNFTLSVGLEEVSDLRGRFQRALDAVEKVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUG0</accession>
    <name>A0A1Q5TUG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box protein pof12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUG0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="58314" checksum="29448D360C8BFBC8" modified="2017-04-12" version="1">MSKRRRDDIQLDLPPTKRLSHRFHTLAGDSELWKRQYYSQWVRPRARRLANVTRSSLPPRVEYTPKVSTWFDHSHLAEEGKATNWKGQYRLRHNWSTGVCRVTEVEFPRPPAPPVLVKLCAGVVFTADQAHGLRAWCAKDPAYCLASIPFPKEIDETAVCPTALAVSQLDDEQEIVVGFDDGHFNRYVFDMETSRLYLQSSHIGFKDGAITAVALSSPYLLIVSQHKSLSLYNLRVSSHVSGNIDESKNLRKLASLNAANMVAPMTLSLRTSGLEIVATIVYSFYHIGCGWSLGIQELRFNPDGEQVESRLASTVDSQYGTTQPRGRTSSRIRRHSTGTDASDGHITAAPVAPSIMHPHPPTSMSYSHPYLLTSHADNTLTMYLLVSDSRRLYVRGGQRLWGHTSSVSAVQVTNRGKAVSVSSRGDEIRIWELEPAVRSLGSRQLLQEDNSIQVNPENKDRDESEFDSAPQSLRGDMSDSGLDGALDDVSVMHGCVGFDEERVLLLREKTVGTQLLECYDFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1C2</accession>
    <name>A0A1Q5U1C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1C2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1C2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="41125" checksum="A05FD6180616F891" modified="2017-04-12" version="1">MKHVFKLQKQGLVRDIPDTYPLRHSAELSWFTNQMYAPMLFKSFGSDFDYLKQYNTDRPFDELFEIYVEITILAAAANSINKLDQDCEHLLWSCRAHQRKALEWYSRNLESIGGRPISCSIDKLKHIKVPLPSAKSMFDSFYEFGSLRQAELHVFFWKAMIIIQLLIYRAQVLVLHCSRPDHQRASIESIPTDPGAYSECMIAGKYADEMCRAIPYFLQDGMGSYGMLKITVNLPYILKSYTHLRCKEKFLWIQKICQSVASDGNDLALCHSQVWWKYWFLCEDPTTNYIRSLAFNEDYTERYHVSVEGDFVKVIKVTKDGESSVASEISDMPAARHVLDVSDTREPLELSQILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1E3</accession>
    <name>A0A1Q5U1E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1E3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1E3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="32565" checksum="CF271F2D92735025" modified="2017-04-12" version="1">MPETAFQRDLGRTEEVANEKVSNVAEVEHVEVSNTPKKSFTQRMAFNRAPLTHESIWKIAIRPVLILFLPPVFWSTVSFGIGIGIFVVLGTTAATAFSQVYDFTVWQVGLVWIAGIVGNLLGIPFGGYFSDWVANRATSKNGGVREPEMRLPAVSIAMITYPGSLLLYGLGINYKAHWIVPTLGIFLFSFGSSAAIGITVVYTIDCYRPIAGEVVVSQVVFKSFITFLMSFYANPWVDRDGYAGAFGAMAGFSFIILALWIPLYIWGKQIRHATLKGRVMRYVHWDLDRETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1L0</accession>
    <name>A0A1Q5U1L0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein bir1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1L0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1L0"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="864" mass="95725" checksum="2AFCF92EEE656EA7" modified="2017-04-12" version="1">MSSEMETFSARLASFDAVLKPEKRRSSTTKGFDVIAWPHQRPSPAELAHAGFYYKPYETNPDNTTCFQCNRALDGWEEDDNPIDEHLKHSPDCAWAIMMDIQQGSSNPATIEDPNSERITQARIGTFGTSWPHDGKRGWVPQSNKMVKAGWYFCPNEESDDLASCAYCKLSLDGWEPKDDPFDEHHRRSPDCSFFVFAQPPGKKGKGRPKKTRTSKASSRLSTQSVATVASEAPEASEMDIDEAVDESMMSQATVKPKGAKRGPKPKGKKAKKEDADLQSDMDLDTNEPSQPEPAKPKRAGRPKKRVSEEMAKDDFDPVTRAEPGSSVEPPSKRRARGTRGSSVSQTYKHESQDHSMLDTASVADSQEDEPKKTRKGSKKGTTKSRKASEVSVTSKSTSKARMPRDSELEAEIEAGLEVDYPELVEPEPEPEAEPELELQHEPEPEPEKTRASKKTKAGKKSKAGGKAPEPPQEDPVDYTDIQEEQPEVPTESAVVEVADEEEAPAPKTKSSKSSKKKVTKKAKKQETVQEEEQELEKDKAGESERDEPEHHDSFVSVEIIKPEAEPQPEPEVEQPAEKPVKKKSSKKEDKPKKSKKTKKVEASPPPPAPQPIEDELGFASSPRDEEDYGTPDDLPDQIQVAPSPRVPSPEPQQIHERTPVPPKTAKRFSDIPQEEHLAQSLAESHSSRSNERRDSQRGRTSNGAVSPLPVPHQSTPSLSPQSSDAENRPPSSLPSAKRPIVVASPPKEKIIRTPLAANTPSPSKRNLNAGFPASAHPWTPVDIDEVLFGEASDKENADLVGLLNGAKASLTSPEKRMTVEEWIRWNAKNGEERLKRECERLVSQFEKEGDRAMRRLETIECID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Q6</accession>
    <name>A0A1Q5U1Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Q6"/>
    <dbReference type="OrthoDB" id="4503765at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012163084" evidence="2">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="275" mass="30248" checksum="D612984A88597443" modified="2017-04-12" version="1">MHSTLTTLFLLSTPIHAGITARVWTHFYPNCPGEPFSNLDTYENYEETAPSQVITTGMCANIGVPSYEHNLVSAISVDAELLSQQSGHPYPPENGPSCNITVHEVPECIDPPLITRELRQGVEVSQCEPRSFAAYSEVWLQLVCDEKSEESLQDQAQDIPRIEGTAKIASAESAANVQTPGSNAFSWSKAQSEYSSGRKPEEEGRVNSDGHAESEKIVHDIMEKIRLQAASMVTGKHNVTLPALNVTLHHNGTASGNRTLSRRKLSVLRNRVARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4H8</accession>
    <name>A0A1Q5U4H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4H8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4H8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="53805" checksum="7D038F56C2F58830" modified="2017-04-12" version="1">MSGPAVMALCGLLVLYVLRTITTYTRLRQFRGPTWTGISNWPHSIAMLRGNCHEWYAEVNQKYGPIARVAPRVLITSSPEVWMHVNNKPGYKRSDWYYKATRIEYRRDNVFSQTDNVKHEQRRKQMAPGYSGRENLHLEESVNERLEDFLHLIRSKYVSSDREIIPMDLATKVQYFTLDVISSVGLGKAFGMLESDQDVDNYLQSSEEGLTIGHNALALGFSWLAQAPFIGRFIAPSPKDNNGFGKMMAACFRLVDERAASSTDKRSDMLASFMRHGLAGDELRTEALEQIIAGSDTTAGAIRCILLHIMTNPRVYVKLQREVDDAVRDGLAPGPGKGFIAATQAKQLDYLQAVIREALRVWPPVANIFSRDVPPGGDTVLIDGESVFLPGGVCIGYSAYGMHLSEKTYGKDAKAFRPERWLESDPAKLAEMVRTNELTFGHGKFQCLGKPVAQIEIGKTVFEVSEVISHVAEKEFLTFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4J6</accession>
    <name>A0A1Q5U4J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4J6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="51" mass="5306" checksum="FEFCDD790DF5D71E" modified="2017-04-12" version="1">MEARPGVCTPYAVRLTGVVTFNATGASDLNVAFTPLSLQIGRPAAGEELEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5D1</accession>
    <name>A0A1Q5U5D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5D1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13042" checksum="C9A8BCCDD6359E64" modified="2017-04-12" version="1">MKKGMCDERVEEEEEEGMEESARQQHPKHLPSLHHSSARTTLDATNPWTMALYVTAEFLVQRLQTRHGWSNGHRSAVSARGSKSTDVRDRPFFTGGGSQRFTKMMEGRAVTGSGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7A4</accession>
    <name>A0A1Q5U7A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7A4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7A4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="148" mass="17077" checksum="DC71B0331A94080C" modified="2017-04-12" version="1">MGYLNKSQHRSCWCSSSTTDLFKHWAANELNQRIADRTADILNQYGTLVARRKYELLSQLPFAFSTTYYDETANNLAQWRDLLDQTQRVYDSLDQATQASFFEMGLHPVLAGKTVVDLYTKAALNGLCYRQGRISTNRLVQEVHDFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U808</accession>
    <name>A0A1Q5U808_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U808"/>
    <dbReference type="OrthoDB" id="4499616at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="20498" checksum="BC8139996DE9C252" modified="2017-04-12" version="1">MSTYLQYDAICNELEAIKLHDHESAAYGLWNAILGVQFPVAQEYIVRPQDQHGSQSGARGFSDLHVVQYRNNATEPEKFLIVQCKRAGTESQGAVWEEAVDQLDRYLRATHGKRAPAARTPVYGIAAVGKWMRVYKYDDINQCVLNWAPRRMRWNRWNLKKNDAQVQRILDEILRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA87</accession>
    <name>A0A1Q5UA87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_5271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="MNBE01000525">
        <property type="protein sequence ID" value="OKP09380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA87"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP09380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="38143" checksum="E7A28D467F1985EE" modified="2017-04-12" version="1">MTSSETAQNLSFVLEGIHKVKFEDRPIPALRNPHDVLINVKYTGICGSDVHYWEHGSIGQFVVKDPMVLGHESAGVITQVGSAVKTLKVGDRVAMEPGISCRRCEPCKAGKYNLCENMAFAATPPYDGTLAKYYVLPEDFCYKLPETLSLQEGALMEPLSVAVHIVRQARVAPGQSVVVFGAGPVGLLCCAVATAFGASKVIAVDIQEARLEFAKEYATTSTFMPSKVAATENAERLRQENGLGAGADVAIDASGAEPSVHTGIHVLRNGGTYVQGGMGRSEIQFPIMAACSKELTLRGSFRYGSGDYKLAVELVSTGKVDVKKLITGTVKFEEAEHAFKEVKAGKGIKTLIAGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAA1</accession>
    <name>A0A1Q5UAA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_5226</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAA1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAA1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="13">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="12">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP09404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="740" mass="80748" checksum="36E24D026178E131" modified="2017-04-12" version="1">MRPQLFRAAARSLRVPRARSFATTAPRAAEVELTIDGKKVSVEAGSALIQACEKAGATIPRYCYHEYVFNSLRPESSGDGRMCLVEVERAPKPVASCAWPVQPGMVVKTNSPLVHKAREGVMEFLLANHPLDCPVCDQGGECDLQDQSMRYGADRGRFHEVSGKRAVEDKNIGPLVKTSMNRCIHCTRCVRFMNDVAGAPELGTSGRGNDMQIGTYLEQNLNSELSGNVVDLCPVGALTSKPYAFRARPWELKHTESIDVLDALGSNIRIDSRGLEVMRVVPRLNDDINEEWINDKSRFACDGLKTQRLTTPLIRRDGKFVPSTWEQALAEIAEAQQKLQLQPNEFKAVAGHLVDTESLVAMKDMANKLGSDNLALDQPGGSAPIAHGIDVRSNYLFNSKIYGIEEADALLLVATNPRHEASVLNARIRKQYLRSDLEIGLVGEEFESTFEYQNLGVDVAALKTALSGEFGKKLAGARRPMIIVGSAAAEHPDAKAIFEAVGSFVEKHASNFNTPEWQGYNVLQRAASRAGAYEVGFTAPSPEVAQTTPKMLWLLGADEISQTEIPKDAFVVYQGHHGDKGAQFADVVLPGAAYTEKSATYINTEGRVQVTRAATSLPGAARDDWKIIRASSEFLGVPLPYDDIEALRDRMEEISPVLRRYDVVEPTSVSSLSKVQLADQNKGSSATGAPFQKVIEDFYFTDSISRSSPTMARCSAAKATGNPETNFMAAGEMSPQALYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAA6</accession>
    <name>A0A1Q5UAA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAA6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="239" mass="26916" checksum="D1F82660AEF30C25" modified="2017-04-12" version="1">MSSFSRRGEGIDNYLMNPSMAVPGTYSHPDSHEYGAAGSGTYHFPQHSFNPYGNQFSPSYGQQSNMSSGMQHLQYASEHTIPSMSTTEDMRLHHPPPQYMAQPRYPQSPRYLPLRDALGETDIESQESRNEGTLLSEPVVPALDGFPDVKEFDQLMQSYVDDLSVKKQDKALIHAKRARNIRTVLIDPKDTAVESAQFRFWVKKMFKLQPVGMGTADVRHPSPGLIVYTNLTNYLSAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAF5</accession>
    <name>A0A1Q5UAF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAF5"/>
    <dbReference type="OrthoDB" id="4453736at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="139" mass="16085" checksum="EF9598DB72435E1C" modified="2017-04-12" version="1">MSVPFQGRHADLQGLIDILTHRFRSRKSLKIILYLDDLFLPDLKIILGLLKAPSCSITLEERWIQWQYPVIRERVIGTYERDYKSFVEAALKDTGYPFRSTGPSLEQFEVDETDDASTLGSKIIGKRQRTWLEATPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAS1</accession>
    <name>A0A1Q5UAS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000490">
        <property type="protein sequence ID" value="OKP09567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UAS1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="85"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="637"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="679"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="721"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="763"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="805"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="847"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="889"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="931"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="973"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1099"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1288" mass="141953" checksum="A7B4160657963C4A" modified="2017-04-12" version="1">MGTNISYDGSNSGLQIGENHGDITAQFVQPEASLNQACLRDLRTTSPHDDKDRIEQTNGGLLIDSYRWILDNEQFKQWQDNQSSRLLWIKGDPGKGKTMLLCGIINELTRSIGDNANLAFFFCQATDVRINSATAVLRGLIYSLVVRQASLLSHVRSRYDQAGKTLFEDINAWNALSKIFNDMLKDPTLQNTYLVIDALDECTKDLPLLLNLVVQESSTYPHVKWIVSSRNWPGIEERLNTTTQTAPISLELNELSVHNAVQQFIRHKVHQLAEVKKYKDEMRDVVYRHLSSHSQGTFLWVALEFPPGLDALYGRMIDQVRTSEDAEICKRILAVMLIAYRPITLDELTALVEIPDDLSDDDEALLEIIALCGSFLTWREDFIVFIHQSAKEFLLEKARIEVFPEGQEAQHLAIFSRSLQTMFKTLQHNILDLKLGVSTDGFTHLRSNPLTAVKYSCVYWVDHLLEGWCGEDEYHSLDDGGCVYRFLQQKYLHWLESLGILGSVLEGITAMLKLEDLLQKKGESRDLLDRVQDASRFIRYHRNAIEISPLQVYSSGLVFSPTQSTTRTCYQKEKPDWILNSPVVDGSWSSCLQTLEGHSDSVTSITWSPDGSRLTSASYDRTVRIWDPATGQCLSTLEGHIDSVTSITWSPDGSRLASASYDRTVRIWDPATGQCLSTLEGHSDSVTSITWSPDRSRLASASYDRTVRIWNPATGQCASTLEGHSDSVTSIAWSLDGSRLASASYDKTVRIWDPATGQCATTLEGHSGLVTSIAWSPDGSRLASASSDKTVRIWDLATGQYASTLERHSSFVNSITWSPDGSRLALVSYDKTVRIWDPATDQCAATLDGHSSRVTSIAWSPDGSRLTSASHDETLRIWDPATGQCLSTLKGHSDTVTSIAWSPDGSRLASASADNTVRIWDPATSQCASTLEGHSDLVTSIAWSPDGSRLASASADNTVRIWDPATGQCGSTIEGHSDSVNLIAWSLDGSRLASASSDKTVRIWDPATGQCASTIEGHSDSVNSIAWSPDGSRLALSSYDKTVRIWDPATGQCATTLEGHSSLVTSIAWSPDGSRLASASSGKTARIWDLATGQCAATLKGHSRGVMSITWSSDGSRLASASSDKTVRIWNPATGQCVSTLDIHSYHFLQFDRSTPTHLHTVIGTLNLGSTEPVAPGASRLTLPKIHGFGLSGNISWITFNGSNLLWLPPDWLGEKKRLVCLHEVQNNHLVLSVSTDQRPQFSDGVHTSTFPGTNKDRKSSWNYLAIEFPEGFSNYKADFITVTTFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBS7</accession>
    <name>A0A1Q5UBS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="70" mass="7699" checksum="A569B7F0E9E100A1" modified="2017-04-12" version="1">MARKGSKERVRLILRRGECQRSISVLISEAGVCTPLQKRIQLIRMVISESVPNAGASVFFSSIDVHSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC36</accession>
    <name>A0A1Q5UC36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000401">
        <property type="protein sequence ID" value="OKP10020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC36"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC36"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="111" mass="12241" checksum="599D9718D4C3F081" modified="2017-04-12" version="1">MSYDLHGKWDLGNQWTGEYLNPHTNLTEIGKALDLLWRNKIDSSKVVMGLAFYARAYTLADPSCVKPGCIFASGANQGNCSREVGILLNSEIDQIIADHQLSTTFYEDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCI0</accession>
    <name>A0A1Q5UCI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCI0"/>
    <dbReference type="OrthoDB" id="4416590at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012118079" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16674" checksum="8FC13FC689CF6DEA" modified="2017-04-12" version="1">MKSVIATIILAASSAFAVPTAVKRSSSFQVTDFWAIAAYPGSSASMHFALTDPNYPNDTPTDCNLIWTYGQSPKQSARCNNGEYYIKFPQGAPDYNLFTLELERVNGTTTEDRQILLSSNANGGAPGTKWICVNNPSENIRIRCDYDGTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCL1</accession>
    <name>A0A1Q5UCL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCL1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF4">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="309" mass="33508" checksum="3034A57476009901" modified="2017-04-12" version="1">MAFNRTALSNLSLEDERYLNQQLSPQSRPMELFPTTKASDPLPGNWSYDSAIDLFSLNPAEMDPVSFDFADSLTNADSKDLFMDSFGTPTAISGFSMPTAEDTVSLSSDLDSDDQSWSMSARPSIDMTSPTSTKPTTRASITSTSPTTSTSSTRWSSSPEIKPQQYNPPQTRTDKRRKTRSLSDESNTSSSSAQQPPSTSASIAQDPQGRNAAKRAAHNIIEKRYRTNMNAKFLALEKAISPAGVQKSSRAAGVGAGAGSLKKSEILSNALAYIERIQQENMAVQKELAMFKQGIVPGGMWRGSKHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCN5</accession>
    <name>A0A1Q5UCN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyamine N-acetyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCN5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="186" mass="20079" checksum="AF95EBF378DF8D1F" modified="2017-04-12" version="1">MSPSDHITQCPGLSGFNAYIRLLTISDVKSCVAVESTFPEQERCSEEKFKYRLTACPPLSLGLFIKTQTGIDQQIGHVIGARISSNTITEASMGMPENWHSLPVNEPVIVDGQVIGNDPAGENVAVHSVVTIPQFQGKGIGRALVKAYIEYIKEMGSVSGVRSVVLIAHDYLMGANCSEGSRSLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCX1</accession>
    <name>A0A1Q5UCX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rpb7-binding protein seb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000361">
        <property type="protein sequence ID" value="OKP10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UCX1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="8">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="472"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="641" mass="69346" checksum="BE219F5693762E3B" modified="2017-04-12" version="1">MSSAVAELDSYLRSMLALKPPGVEGSKVHGITRLCTANVQDEPVLXQKIYTHFKKAPATHKLGVLYVVDSITRHWVDATRKAGRPPRSAAPDGTFAGGIDRVTKLLPVLMTDVINNAPQDQKEKIKKLVDIWECGCSFPPSMLTSFREKLNTPTRNVQATMPKGSPAPSFYPLEAPALLQSPNGSPAAATDTTGILKPLTDMAKRSTVTSASPSNPLAILTPAAAALHLASSVHSSLLPPSTANPYTGGGAGAIANPFAALSGLGQNPAMPQLQSRSQTPNLLEAILPQWPAAAPALDGNAMSRQQGISQDQWAAALQPVNITDTLGAAYPPQLPSFGAVPCQGSGGRGHPDAQNRVDRDRRRDRDHSGSPPGGYGRPSHSPGWDRHHPASPPRRRDRPVYDEYYGESPGRRGDPRDARGRRGNQYRKRSPPGWKRRSHSLLRKDLNLPSPGPKLVAWDYSIRQGNIKVLSRTLFVSGISSEARLRSLFNKFGVVQTCIVNIDKRHAFIKMISREDAVSAQFRSCEMQLRTRWEVGFGPRDCSDYQTGISVIPIERLTNADRKWLLTAEYGGTGGRPIESGMVVEEPDIEIGAGLSSRAISRRIAASTKRGRNSDGFGGGRGGRPDRNGFGSPSQGRLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDZ0</accession>
    <name>A0A1Q5UDZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate-forming enzyme AfeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDZ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDZ0"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="474"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="66154" checksum="C42FACF3E5DC3B27" modified="2017-04-12" version="1">MGYWNPNMSVAAGTASDPLLHQDLHTDLLTFTFCGSTPYNPNQPLFIDAEDPSRSFTATQFRQLVRTLIAGFKAHNVQQGDCVLLHLGNSILYPALFFGIIGAGGVYMGSNPRSQQQELDHIVGLAEPKLILTTRDALKTVQEVAVTRGISPEQICVVDDRAVDHCAQLFLWYELGYSAGTDFFAKAGGDNGRHLNFANMLCYGESDWVMFTDPMSAQNTPAAMFSTSGTGGLPKAAILSHHAIVSHHRSIQYDVPYPVSRLMSLPMFHLFGALWTHLFPVRYGHPLFVLSRFETKQFLATVHRFQISETYLVPAIIHTINRCTLPVSEYLASLRYVGVAGAPIDGPSIVQFRSRLHPMAYACQLWGMTEVGVAFQTRYGQHGDPGSIGTCLRGYEVRLIDHDGNIVRSDERAGELYVRGPGLLLAYKGRTDAKEAQGWYRTGDVAFMKQGHYFIVGRTKELIKVRGWQVAPAEIEGVLLQHPGIADVAVTGVNLKDGSTEVPRAFVVRSRDPSVSRLSAEEVYNYARQHLASYKSLDGGVVFVEEIPRTASGKIQRFKLSQMNDYREMVASLLQRFETGGTSAVGHALPSSADVPPVGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE53</accession>
    <name>A0A1Q5UE53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE53"/>
    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF5">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27994" checksum="F0DBFDA69921B0D8" modified="2017-04-12" version="1">MSSSTASTTTEVNPCFQQLFTELENRFQSTTLGPEKWYILAIATLAASPDPERADQLYLHLCSQPNNKTPSRRQAIVRRLREALIKSVPIVGVCKPIEAILSIGKVEREEDKDYTCTRSGWHCDENNHERGTAWMQKLYSRDTTGTLNLFAAHKDFSWLSEEITYGLFLSDRQVLDDVDTQLVVLPGIMSQNLPNETHWHIRGTRRLGLPKEEVEVIWDCVQLVARSFDVKLNKVPTVEQVEYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEG7</accession>
    <name>A0A1Q5UEG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEG7"/>
    <dbReference type="OrthoDB" id="4503311at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012389126" evidence="1">
        <location>
            <begin position="19"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="16349" checksum="25D11F6560E5240E" modified="2017-04-12" version="1">MQFKVASIPILFACLASASSFTIAPSASFTSSSATFSVPSVSVPASSVVASRVSHIPSASLSSILAASSSAAALNTAEYDCIYQGRGCDWTKSEYGYGSNYCGSSPYQPGQQLSDGSVILAVSKDGSGDCASKAGAQCCKVLADNPCKYGEKYLECYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEV5</accession>
    <name>A0A1Q5UEV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_3525</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEV5"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="111"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="43328" checksum="B354C1FAD5BADFC3" modified="2017-04-12" version="1">MATKTLEARFEHLSVKDEKETGNDRTYGKHKGSVSTAVSLSGLGGSASNSNRAHLLKLALQNTNDNKVNSMNVPPSPGKGAIVSRNTDENGDQRSATPLYDQPRSLHLGMFEIGKPLGKGKFGRVYLAKERSSGFVCALKVLHKSELQQGGVQKQVRREIEIQSNLRHPNVLRLYGHFHDSKRIFLILEFAGRGELYKHLRKEHRFPEWKAAQYIAQMAAALKYLHKKHVMHRDIKPENILVGIHGEIKISDFGWSVHAPNNRRQTMCGTLDYLPPEMLKPGSQDNYYSEKVDLWSLGVLTYEFLVGEAPFEDTPVMTQRRIARADMSVPSFVSPEAKDLIKRLLVLDPEKRIPLDEIQRHPWIVKHCVKDPKRSSGSSKDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFD4</accession>
    <name>A0A1Q5UFD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFD4"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000692">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="536" mass="59851" checksum="F9C2546C8268705E" modified="2017-04-12" version="1">MQHSQLAPLPIDVPFRIVSKTIGQGAYACIKKAAPLDADNPIFAVKYIHKDYAARHGKISARQLSLEVTVHRHVTGHNNIISFYQTGEDEIWRWIAMELAEGGDLFDKIEADEGVGEDIAHVYFSQLISAVSFMHSKGVGHRDIKPENMLLTSDGNLKIADFGLAALFEYKGTRKLSTTFCGSPPYIAPEVITCSTRGQNKGSGYHPDLVDIWSCGIVLFVLLAGNTPWDSPTDDSYEFHEYLTTNARPTDELWQKLPPATLSLLRGMLTVDPKGRFSLEDVRRHPWYTRSNKYLSSDGTKLKDPINLATSMFESLHIDFSQDPLSQKRPGASRSDPMDVDMHDQEVNLSEGMSSTQPEMAGGNMVMDWHTPHLAGEYYSTQPADKPFSSQQMEISSHLEDEPSMSQFSQKPSVPLSRTQNAKVFQDIIPPRSLTRFYSAWELKLLVPLICEALHRLGVPVPSVPAVSSGDTSAMIRVIAKDGRMCSLQGKVLIECVSEGLFEVEFVKIKGDPLEWRRFFKKVAVLCQDAVFKPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG47</accession>
    <name>A0A1Q5UG47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 family protein C10F6.14c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2919</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG47"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="165"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="653" mass="74743" checksum="C896CFE352B42824" modified="2017-04-12" version="1">MAHATLLRSLRLPIAPRSHHLWRPLPRRAVHAGEFQPFVPPSPSSLGKPTPAKTYTRTRKWLRRLFYTSLATGIVYGIDSQFYASSLTRTARTFSLGLLVALDYKINFRPHPPLASSIAAVHARNAERLSDLLRHNGGLYLKMGQAIAMQSAILPPEFQAMFSRMFDDAPQNDWKEVEKVIREDFGKSPEEVFGVSFDGEPGKGVMERRARASASVAQVHWARLQDGREVAIKIQKHEIVQQLAWDLWAFKVVTFIYSKLFDIPFYSLVPYISERLSLETDFENEATNSETMARLIAAEPRLRDRVYIPKVYRELSSRRVMTAEWIEGVRLWDKDSITRTWRGGWRQGSPGCRGTPLDPPESKVLPQTPRNVQIAKSKPERTHWRGPNNRGGLGVSLKDVMTTMVDLFSAQMFLFGWVHCDPHPGNILIRRKPSGQPELVLLDHGLYIHMEPTFRHQYARFWKALLTFDNRTLSEIAKGWGVNNADIFASATLLRPYRGGDMSTQRGIEGLSKHERAERHYEMQQAARKAIREILGDENKWPRELIFIGRNLRIVQGNNQFLGSPVNRVKITGMWASRALVEASDLPLAEKIRNLGRHVVFRIVLFTSDVFFWFTKIRQFLRLGGGMEDEIEAQMQHMAKDMGVELNHNVFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH80</accession>
    <name>A0A1Q5UH80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH80"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="189"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="510"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="556" mass="60562" checksum="73BE76613CD0CF26" modified="2017-04-12" version="1">MQASNAKGGHKRNLSNGTPDNSPLRRSKRQRSTANLKEASSGEDSEGEHEVVTTPKKGSSAKATPKAEPAAKSKKTQVAASFKKEVTEGTEIDSSVTVAKGESGVKTEAGDIAVKTEAEAASSVKAKPARKARKTKEEKEAEAMPLAPRTPGLKMFVGAHVSAAKGQYLGLCLGWMVKKLIQDSSSSGNAFALFLKSQRKWDNPPLQDDVRDQFRKMCAEQNYDAAKHVLPHGSYLVNLAQNDKAKAKQAYDSFLDDLRRCEALGIKLYNFHPGSTNQTPLPEALARLADSLTRAIAATSTVIPVLETMCGHGNTIGGTLTEFRDLLALIPKEHHSRIGICIDTCHSFAAGYDLVSPEGFKSFLSEFDNLIGLKFLRALHLNDSKAPRGSKRDLHANIGTGFLGLRAFHNVMNEPHFEGLPMVLETPIDRVPGQSASSADDDDADSCESESEKKGKKKVVKKGGKRPAGASPAAVPDHGVWAREIKLLESLIGMDPEGEEFKALEARLSEEGREMREKQMEQYERKMESEKKKEAKAKEKGQKSLMDMIKKGKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHJ3</accession>
    <name>A0A1Q5UHJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UHJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1406"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
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        <location>
            <begin position="86"/>
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        </location>
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            <begin position="103"/>
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        </location>
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        </location>
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    </feature>
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        <location>
            <begin position="995"/>
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        </location>
    </feature>
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            <begin position="1011"/>
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        <location>
            <begin position="1074"/>
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        </location>
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            <begin position="1097"/>
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        <location>
            <begin position="1158"/>
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        <location>
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        <location>
            <begin position="1301"/>
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    </feature>
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        <location>
            <begin position="1342"/>
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        </location>
    </feature>
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        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
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        <location>
            <begin position="1446"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1479"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1503"/>
        </location>
    </feature>
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        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1583" mass="166416" checksum="7F1EF30F3D38D769" modified="2017-04-12" version="1">MATAATQSVSEEHLPKDPVSVEPVLAATPIAIDEKSATNGDSTADSTTTPAEPEVPLTAAQKKKAKKNKKKQQKKQESISSVSADVSEKEAPVEARSAEEETPAPAAAEESTPKPVAEEPKAAEESKVEEVIPETTEEIPTEETAVEEPAKEEAIVEESAKAEPVEVPTEVSEEKPTVEETPEISTAKESVEESTAKEVTPEEASEAVKEVTEAPAAEEKVETAEVEEHTPAETAVEQPTVEETTPEEVSEAVQESSEAPAAEEKVETTQVEEPSTAETVKTEQPTTEETAPETIKEEAPAAEKKTEATRVDEPVTVETTAVEQPTAEETAPEEASEAAQESIETPAAETVAVAEPTAKETAPEEVSEPAQESIETLAVEEKVVEEPTPAATAAVEPPAAEETAPEEVTEAAAAEEKVETTEVGESAPVEAAVVGQPTAEETGPEEVVETAKELTEAPVTEKKIETAAVEQPTSEETPAAEEKFETAQVQEPTPAEASVVEQPAAEETTPAVEEKVVEDEEPAPAETAPVEASEIAKESAEAPAVEEKVEAAEVEESTPAETVVEQPAAEQVVTEEAPKESTEIPAAEEKVEETATEEQIPEATQESTETPVVEENPEAERVEDSTTTETAAVEEPKVKEPVTEVASEAVQEPTEVSHAEEKTEEPAVAEAVAVEQPVVEDPVTEQAAPVEEPKEESKVEEPVAEPSSTEPAATGESASKTEEIPAPNVETIEPAATEEATIAEPVKTAASEEVPVEEAKVEEPAQEEPKVEEKTEESAKALAVDEAAEKPAEEEVAPAAAVEPVVETAAVDETPADEPAKETVSETPVETPVETAEKSLEEPVKETAPEPTEEVAEVETAASEPVVAEPVSAEETPVQEPEAPVVEEQKAEEPVVEALATSKPAVVDSTPIEEDNKAAETETVEAAEEATPAPVETTEVNVSEPVEEKVAEPLAEETLAPAVEEKVVEPVVDKVAEPIEQTSEPVVEETPEPVVEEKAAEPVVEEKVAEVESTAAEETPVQEPEAPIVEEQKVEEPIAEAEPVVETPTPIESAEEKVAEPIEQPVQEAIEPTAEEKVPEPSEEKVVESIEQSTEPAVEETSEPVVEESIAAPVEEVPEVVAAEESSPVAKAIETEEVAAEIPAAKDEVNEEEKEVEAVSAAEPVAVEEPALTEAEPETPAVETEQTAVVLEEATPEPAAVEKSIPAVATAGVALAGVAVAGAAVAEEITTAPEDTTARELVEPVAEPEAPTATEHVEAAPEPPVEESVQETAKEALVPEESAPAVDEPAQAVDQTSTESAEPVPTPAVAETETAAQTGEAAPVEETAKESEPVNEQDETSEQPAAAEEVPSAPVHTEEPVEETSAPQEEKAEESAKESILTPEILGAGAAAAAAAGIAAVGVSSLLHKEPKDEPVTATTEVAIDDKTDNKAPAAEQQTEDCKPTPFSTSHNMSVPSFEADPVLTALAGDREALLHKLNQPSTDQLTTLTQPTNDDKQARVEIEAEPTAESSQKATDQLSPENAATSNSNEEDARPVSQNRSVTAVSLNSASDNWLKAFLRTVFVGFFGTIFSPFRRRGKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHM3</accession>
    <name>A0A1Q5UHM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHM3"/>
    <dbReference type="OrthoDB" id="4504921at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="362" mass="41284" checksum="D1AF15C3926FB4E7" modified="2017-04-12" version="1">MAPRRSGGGSSSSYSSYSSNNPWSQEIEFSLDMLRSKTLFIAGFAFDVLTIIALIGFLVWTCLIHNGRGQLKGVLWALLAYLVSMITILVYEILFFANATVQMYYVIDLMLNEFFGLAAGCLIFFVFYHLIHSILNRLTDAGKPYAVVAIVHWVILGLVSVVSLATFGLYVGFQVQNVQNYYYSPIAKQYNNLEAARAIIWWILSLEIVAWFIFIVVKAGSHRFASKFPIFTLLGGSIAWMALNLAYAVIYIRFSLENVIQPNYLACLQSVLQFFFIVGTFVGILLACMKWRSVDDREDKNVAAQYPYPPGQYQTYQAYQQQNPTQMRAPYAPQYYQQQPHETYPEPVPHHTHQPEQQRAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHN5</accession>
    <name>A0A1Q5UHN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHN5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="208" mass="22605" checksum="9BA3094085705B8F" modified="2017-04-12" version="1">MAFVRRSALRATIAAQSFYAAPVARRTTQLLGRRFYASGKGHDEHKTSDLPWCVSTRRIKLALLHGPEKKPHGDGHGDEQSTEHAGHKEKDQGSDQAEEAKQPAESETDDDKEPDNSSEEPEKSDKSQEEDEEVQAAKKKDGEEKKGEKPAKKDAGADESSGDKSEGKSSDQKDSTKADSKNTDDKESNKSDTSDGNDTAKGNESTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHV5</accession>
    <name>A0A1Q5UHV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHV5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="113" mass="12634" checksum="2C5598DC3586E3DD" modified="2017-04-12" version="1">MEISSQTSLAFTGARFHTLAFTSFAVIATLRLGVHTLEQLVFDSLRQLVDAFSSELRQMDPFLTRQYVQLPTMCGATSSFNAVLDSRCSAQRYREVAKRMLLPAARLSALWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIG0</accession>
    <name>A0A1Q5UIG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIG0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013316273" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25190" checksum="070927DE0381701C" modified="2017-04-12" version="1">MAPSLASASLLSLAGIAAASASPSPLVVSSPAKVPTGASWSVPHDFASFSFPAHFFKDYAGTISLCWNGCPCDRVWYNASQKIDSYNWYNESSLTAALGIADRVYIGPAFFGGFNNFPGTHWSWQINMGTDYGEEGGLDNAMEVAKLVMDRVQDRLESFEIGNEPEYFVTLGERQENYTIDDYVRDWNKYADAASERVLKGNKYRLDETRFFQGGTFTSGQDEEWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIJ1</accession>
    <name>A0A1Q5UIJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIJ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIJ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="21887" checksum="88199C1AFD4D4D81" modified="2017-04-12" version="1">MSRLVNSVKSFSNASAAAARSARQPTSFQVFRDVPELHQLRRKLVQNDRTIGFVPTMGALHEGHLSLIQEAARENTDVFVSIYVNPTQFGVNEDLSSYPRTWDGDVKKLEKLNEELGNLGAGTGRITAIFAPTSKVMYPTLPPSSEIDGHGSFVDITPLARNLEGVSHPVFFRGVATICMKKFNMTTPDRVYFGQKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIQ2</accession>
    <name>A0A1Q5UIQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIQ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIQ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="383" mass="41953" checksum="45D4176DF49E7754" modified="2017-04-12" version="1">MRPDDGLLPPFLGALKACVSVILTMCYGVAARRLRLIHDATINDMSALGIKLFLPALIVVNLGRELHIGTAMNYLPVLGSLRLILRGDESTADGIERAQSYFLVCAVVSKTIAYVVGPRMLHDGENAETRPSSIEDQHVSECEDEPLTETTSLLPERAQTAQHAVGMRIHSWTTWLVSFFPYRVREELMAPFGDPFAGVAICCTLVGALLGLVPALHRAFFFREEDGGYLQGWLTASVRNIGRLFTTLQIFLVGCKLAVAFERMVAQGEADESSRIPIRAMTIIFLVRLVAWPAVSISLIYGLAKHTKLLGDDPILWFSMMLMPAGPPALVISGLAEVAQASETEKMAIAKTLTEQVLSQLQPWAPVQLQVAPQSQPMMNIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIR0</accession>
    <name>A0A1Q5UIR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIR0"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="674"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="720" mass="81643" checksum="7F5E3480FC713C17" modified="2017-04-12" version="1">MADENGAEPIKRDVRNHMLFEIATEVANRVGGIYSVLKSKAPVTTAEYGDRYTLIGPLNKASAAVEVEELTPSSPAMRDTIASMQERGIEIVYGRWLIEGAPRVLLINTGTGYRWLDEWKGDLWNTSGIPSPSADHETNEAIVFGYMVAWFLGEYIAHERRRAVVAHFHEWLAGVALPLTKKRHMDLTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERAAAHSADVFTTVSHITAFESEHLLKRKPDGVLPNGLNVKKFSAMHEFQNLHSQAKEKINDFVRGHFYGHNDFDLDNTLYLFTAGRYEYRNKGVDMFIEGLARLNHRLKASGSTTTVVAFIIMPAQTSSLTVESLKGQAVVKSLRDTIENIEKGIGKRMYERCLEWKEGDNMPDEKDLITSQDRVLLRRRLFAMKRHGLPPIVTHNMVNDNEDPILNQLRRVELFNNSSDRVKIVFHPEFLNSSNPVLPLDYDDFVRGTHLGVFPSYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRAKGVDDSVNQLTEFMFNFTLKSRRQRINQRNRTERLSDLLDWKRMGLEYVKARQLALRRAYPSSFDGAEDYFDIIGGTDQKVSRPLSVPGSPRDRSGMMTPGDFASLQEGREGLSTEDYIAWKLPEEEEPDDHFYPLTLRTRKTNDRPQSPLDSISINGGGPAPEGSPKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIR9</accession>
    <name>A0A1Q5UIR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIR9"/>
    <dbReference type="OrthoDB" id="3439627at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="87" mass="8724" checksum="23DD1248A90AF3DF" modified="2017-04-12" version="1">MVRGAEYDNGVPQSDNAIEAGATKAHGTGATDAPIDRVNKVAPMPEETGSQREVYSGMGAPGSNSGKGGHEPKTLGGNKGLGAQGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ62</accession>
    <name>A0A1Q5UJ62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 1 regulatory subunit SDS22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000446">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit SDS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000312">
        <property type="entry name" value="Protein phosphatases pp1 regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="401" mass="45478" checksum="6A29B1CB0BA87AA6" modified="2017-04-12" version="1">MANPHPEFPGSRQNLGQPAPKAPRNRNRTTIPPPPATSNSHLPLSTHPTMKNKEGWDGKLRMEPKAVITNPEALEDSDYSDPEAPPVEEIDADEDLLADEDVNVEDIDLVHCRVSSLSALKLERFTKLQRLCLRQNQITRINFPSNLGETLTELDLYDNLISHVKGLEDFHNLTSLDLSFNKIKHIKNVEHLKKLTDIYFVQNKISRIEGLEGLDKLRNLELGANRIREIENLDTLASLEQLWLGKNKITEMKNLDALSNLRIISIQSNRLTNITGLSSLPNLEELYLSHNAITDLSGLESTTTLRVLDFSNNQVSHLEHLGTLKNLEELWASNNQLTSFDEVERELKDKEKLETVYFEGNPLQTSGPAVYRNKVRLALPNIKQIDASMFFTRLRWFAGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJH6</accession>
    <name>A0A1Q5UJH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_1682</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJH6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="262"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="576"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="757"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1230" mass="138375" checksum="0DF5B67D2631ADE3" modified="2017-04-12" version="1">MDDLESLELLSLVSRVTNELQNYLGINDKTLAEFVIDQHLKCNGSFPEFKKLLDEMGAEFPQSLMESVDRLVLTMHPKYKGKKQENGDSGGGGGDIMDELDALEKKSRVFKGLAVPDRGQRWEEDDYLDRPADNDTDAQAGAMDDTFAMLEGLAGKAKDDKPHGPRDDHRSRKRSRSPDYDDHDRGRRHRNKHRSRSRSPHRRSKNDDFIDEFGRSIGKYGDRDSDRNGHSDRRRHRDRERNENEDFRRPPPVELDDAPVLYKVYDGQVTGVKDFGAFVNLRGVQGKVDGLVHVSAMQEGARVNHPSDLVSRGQLVKVKVVSIQGNRIGLSMKEVDQATGMDLVPQKRLASGANMERLDGAPSQDRYGNLSSEVPVIEGSNGRPMRNRKRMTSPERWEIRQLIASGVASAADYPDLEEEYHATLKGEGAFEEEEDVDIEVRDEEPPFLAGQTKQSLELSPIRVVKAPDGSMNRAAMSGTNLAKERRELKQSEAQDKAAELAAEVDLNAQWQDPMVAPEDRKFAADLRNTQQKPDEPIPEWKRVTMGKNPSLGKRTDMPIKQQRESLPVFKFRKQLLDAVKDNQLMIVVGDTGSGKTTQLTQYLAEAGYGNNGIIGCTQPRRVAAMSVAKRVSEEVGCRLGAEVGYTIRFEDCTSPETKIKYMTDGMLQREILMDPDLKRYSVIMLDEAHERTIATDILFGLLKKTIKRRPDLRLIVTSATLDAEKFSEYFNGCPIFSIPGRTYPVEIMYSKEPESDYLDAALITVMQIHLTEAGGDILVFLTGQEEIDTACEILYERMKALGPTVPELVILPVYSALPSEMQSRIFEPAPPGGRKVIIATNIAETSITIDNIYYVIDPGFVKQNAYDPKLGMDSLVVTPISQAQAKQRAGRAGRTGPGKCFRLYTEAAYQSEMLPTTIPEIQRQNLSHTILMLKAMGINDLLHFDFMDPPPTNTMLTALEELYALSALDDEGLLTRLGRKMADFPMEPALAKVLIASVDMGCSEEILSIVAMLSIQSVFYRPKEKQQQADQKKAKFHDPHGDHLTLLNVYNGWKNSKFNNAWCFENFIQARQIRRAQDVRQQLLGIMNRYRHKIVSCGRDTTMVRQALCTGFFRNAARKDPQEGYKTLVEGTPVYMHPSSALFGKPSEHVIYHTLVLTTKEYMHCTTSIEPKWLVEAAPTFFKVAPTDRLSKRKKAERIQPLHNRFAGEDDWRLSAQRRQGRGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKU7</accession>
    <name>A0A1Q5UKU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1206</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKU7"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000013">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="250" mass="28245" checksum="CE5660A6E3ABB5FF" modified="2017-04-12" version="1">MFQRTIFRQAQAARSVLAASTSTSAAPLALRRTTRLQSQLPWAMRPFAPQPAARRLYSTENNGENKEAAKEGEAAENAEEDPVRKELEEKEKEITELKDKYLRSVAEFRNLQERTKRDMDAARNFAIQRFAKDLLESIDNFDRALLAVPAEKLSAERTDANKELLDLVDGLKMTERTLMNTLQKHGLERFDPSEQVEGKAQKFDPNLHEATFMAPSPNMEDGDVMHTQSKGFRLNGRVVRAAKVGVVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULK1</accession>
    <name>A0A1Q5ULK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Imitation switch two complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_978</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="51"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="429"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="697"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1046" mass="120622" checksum="B6617733E56E4961" modified="2017-04-12" version="1">MSRFSALRSVSLRPQPPRSAVSGSPVAGAEVLYKRKPVQYLPRPVIEDDSSEVWVIPETNEVFTSYEPYLQRMDFYKSRRFICEITGHSGMTFFEALRSEVGGNTRWLHGRVLIIWEQLEESREVNNSFPEALKEPILRRIQFSTTSRVDNLVDEIYEEFKSDFYPGEPVLILLEDNSRLHGTIRDKANFAEQLYADGTIKTPAYARYLVKISDRPNEEALLDQDHITRDRKSFTKLMLRGFIKNNVTRESWTGAPWLVKPSVAEEYKISTEVPKHLQYGAKVAEKKAMKKADQEGFFGFFSSQQLPELKPAVKGAKSKMTAHDHAKSREAQYLEYQRSLNGNPTFLPPNNPLRPSKPPLVGDKKMPHPSVVIKDESRPPSPPPIKYPMEDLELAPTKDKTHRPTLKFLMVGDTDDDGAEDLLPDDVEPESVGLLLETWDTLNVYCEVFQLDSFTFDDFVQAMRFSSEEMDCELLVEIHCALLKKLVNSEGNGGAAQISLPDFPSEDSDDSENSDEDDENEESEEEEEESGPARRMTTRGSLAKKEAESLKAQLEEPEEDERIHRAAEMFGNYSWIDRLRRRDFRNGGWELVMIGLLHQLSVRPRLEQTCNEILKHLAPLEEPATQKTAREQYRTLDINLRVKALQIICMLSLETKAIRNYMEECSVQMTEFRKVKIEHQKARKAALQDLRQLHQERKALQPEPEKTTEKSPTPVPELDGLDDSKMTGLEGDSEIPMDTDDEDTPRPRSLRGGADRAAERKRKQDEERERKEQLAKQPKGSKQYQRVLKKIEDQKAKIAKIEEKIESVDNNLREADCPRTKCLGLDRFCNRYWWFERNAMPPAGMPDSSTAEANYANGRLWVQGPDEMERAGFIDLTDEQRKQYQKHFHTTPAERKKHEEGPTHVSTAREWGYYDDPESVEQLIQWLDARGNRECKLLKELHLQRYTIAKYMKNRQEYLTVSAERAESEELPTKRVTTRKKTYLDVNEHRLRCLRWHNGTSLSENGHLHVDPERPAKRQKRNADDTRGSRGTRGKTLTRRGSRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-11-27" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULY1</accession>
    <name>A0A1Q5ULY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULY1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULY1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase C-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="6">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="19275" checksum="B0603F51DC3CE99A" modified="2017-04-12" version="1">MEDCRNIPKMQGLSDDAKVVINTEYAGLYIGQMLRLVLITLFEEGKLFKGQDISRLRREHAVDATFLSIAELDSSEVLRDLREEFEENFSLSPNLEEHKICRYLISLIIMRAARLYACGIAASGFKSRASKALRETFDWLPGELDLISLNPSEDGSGVGAALAAALALGTEYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMV1</accession>
    <name>A0A1Q5UMV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMV1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMV1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="43032" checksum="667955069B0610C2" modified="2017-04-12" version="1">MQSHQSTPPFAADEPAPKRAKRPRAAQACDRCRTKKYNYVADLEKKVEELASRLRNAEARTTASPQSTKIPISQPPAPTGIENTPCSMPRTGSTPQEPTRLPGNAVTHEESAESADDEIKELNHHTNGIEFYGSTSSAAIIGHLKKARDPKSNEEPYPGPAELSLISTLHNSSFSPSCSIGPTAAIEQQNYYFDQAHVFMNGYFENIHFIHPFIDKEDFLIRANDLWFNRAHTPEPSFVALYLSVLSFGALVRVWDEDKLAGLGRFEWSRKLFGEAQAYLNYLRFSNDLETVQCLYMMAKICQNELNPNCGCIQLLGMYGMLMSLSGLYVPGSGGAHMSFRWVQSRGGVSQRPSFELDLEDLVGHVLAGNVRIMSIYNMTAKKMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN04</accession>
    <name>A0A1Q5UN04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN04"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN04"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="10277" checksum="282F8E8D4473DB95" modified="2017-04-12" version="1">MSAYVAKNMSSRQKAWNNATQARLASTTSALEGIKSLKMMGMERALQSHILHLRSQETETSKSVRWIMVASNASGMCQLTADDKFPRLSLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN63</accession>
    <name>A0A1Q5UN63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transporter SEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF15">
        <property type="entry name" value="TRANSPORTER SEO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50698" checksum="BE9AF211167A30C9" modified="2017-04-12" version="1">MSWGHERTANWEITDNAYVSGLKEDLGFHGNELVKLQTMYTIGAVLGQLPFAYLFTKLPMSWLIPFMDVAWGIFTLVQYRATSFAELAAYRFMVGWFEAAFFPGMHYIFGSWYRSDEIARRGGCFYVGLTLGTLTASLIQAGASSRLDGVNGLAGWRWMYIICAIITIPVAILGYFILPGTPDKPNKLILKDKDVQLAKTRLERASHTIKEEPLTWRTFVKVGRNWKFWALLWVDIFFWNACINTSAGGYQLWLKGLKRFSTSRLNELAAISPALGIFYTLFVCFASDLVLGPAWAITVSHLWNIIGLTILVIWKVPESALWFAFMTTYSAVAMSSVLYGWINSQMRYSPVERSLTLIIVNTVAQSTTCWTPLLVFKTVEGPRFTKGYSFVLANAICLITLSHVVQFFIKREERTKARGGSVSGSDSADDSSNLESGPQETNVIGKHDQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPC5</accession>
    <name>A0A1Q5UPC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_14095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPC5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="430" mass="45738" checksum="760E757C1D345636" modified="2017-04-12" version="1">MEGTGACIYISGTPGTGKTATVREVVAQLNGAVLAEEMDDFIFVEINGMKVTDPHQSYSLLWEALKGDRVSPSHALDLLEQEFSNPSPRRVSCVVLMDELDQLVTKNQSVMYNFFNWPALRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYRHTDLMEIISTRLASVPGNIVDPDAIQFASRKVAAVSGDARRALDICRRAVEIAEQEADEAANAESASNDAADDIPPTPSKTPARRNKALTEKGAGDSPAPKPASGKGQPGRVTIATIKQAIQEATSTPLQQSLRCLPISGKLFLAALLARVQRTGITESTFGDVLDEARRIADAAVAVAGAAGAGVKDFLLGGGAASRVRALGFAAMELMNSGVLALEQGSGTKNMLGGSTIPARGDRSSKIRLRVAPEDVKLAFREDVEAKGFGMGIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPG5</accession>
    <name>A0A1Q5UPG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xylanolytic transcriptional activator xlnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_14156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPG5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="182"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="679" mass="76216" checksum="C15F1CB6EF2EC279" modified="2017-04-12" version="1">MGSDHERKEECHYTKAVRKRGRRPRTDPGRNLQREDQDFGNSSPQNQSRSPGDTVISSNTSNQDAPSVISSLENRSYGLDANANANDTGHNTSPSSAEKFATNNPPFSAQKDSLNTLFQTPLSNMSLDHRGSLAGLHQNLFDEVPGSMTDQISMKPPYRCLDSILPHLNGLLSAEEASEMLEIYFNEKHNSMFKSTSPYLLAHVLHPSSVLHPTDPRPTSSALLAVILFCVAQTADMKIFDTPGARERMSVDLYRLSLDLLQPEDPDNYFRTSGSTDTILAVTILTIVISGGHYKADSLKWRDKLIRLVRASGLSMEDQDIDLGPVFYGLYNGDATFRRWLVAKEERRRLFWLVYCLDRHLALSFNMRISIAEGTFCVRTPLPEKLWQSLDTADLNCIPACSLGPPTQISGSGFFEYFLPLARVLGHIIDLHHVRAHPTLGQFIPHEAVHRIETMIAQREQELVDLDGQAESYLANDGALHSFSGQSNGGPSQGVDQFGSPTTGTSKDPKLQLVKIYSTYLLHVFYILLHGKWDPISMIEDRDDWITSESFLTCASHALSASGVVSQILTIDPEMTFMPYLFGIYLLQGSFILLLFVDRMPELGPNRSVEEVCETIIRAHEVSVVTLDTTFQKNFRKVFRSMLYDAQQAGPHSWDEHKARRRELLSLYRWTPLAQGLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPH7</accession>
    <name>A0A1Q5UPH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_14152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPH7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="60" mass="6838" checksum="6DBE5461A4C4D55F" modified="2017-04-12" version="1">MQSTAVKATIRTSKLQCRFRAAQRLQVATLDSPVAERLRKASQATRDLRHASQLENCLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPI7</accession>
    <name>A0A1Q5UPI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_14162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPI7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPI7"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="99"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="348" mass="37663" checksum="9B6330B4DA6B77BF" modified="2017-04-12" version="1">MTADTETQGEYDDGGLTGPGAPTPLSALEGMAGLTARDIKLFLDAGYHTVERIAFTPKRQLEQIKGISEQKASKILGEANKLVPLGFTTATEMHARRSELISITTGSKQLDTLLGGGIETGSITEIFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLAVAQRYGLVGEEVLDNVAYARAYNSDHQLQLLNQASQMMCETRFSLLIVDSATSLYRTDFNGRGELASRQTHLAKFLRTLQHLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIIAHASTTRLSLKKGRGETRICKIYDSPCLPESDCLFAINEDGIGDPSEKDLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPK6</accession>
    <name>A0A1Q5UPK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPK6"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="167" mass="18622" checksum="6B427825D46171B9" modified="2017-04-12" version="1">MVKNPKLAYEAKEPAFLQKLRGHYGDTSGRLERPAARPRRLKDKNEEDDDAPVYVDEESNEVISKAEYEALVGGGTDQKDDNASTKDQPTEKGPDDAQSQTETPAAKQSNLTEVGGPRKRKQVKVVGEDESEEKPEDKQEADKTWPKAPGPRKSKKAKKIKLSFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPQ2</accession>
    <name>A0A1Q5UPQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPQ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPQ2"/>
    <dbReference type="OrthoDB" id="2590867at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606:SF1">
        <property type="entry name" value="CELL SURFACE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39606">
        <property type="entry name" value="SURFACE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="23368" checksum="210B0B723C1AB355" modified="2017-04-12" version="1">MSGFVRKAENALTGNHHNTNTTSSTNHGPHSSNLANKLDPRVDSDRDNRARHQAMGGTAGPHATNVANKVDPFVDSDLDNRGTQASNLGGYGAGTTGTHNRTTVPHTSNVANTLDPRVDSTTMGNQAHYGHTGTTGGLNTTGGMNTSSTTTAGPHSSNIANKLDPRVDSDMDNRARHNAMAGSSHGNPRSGATAGPHSSNIANKLDPRVDSDMDNRNAGFQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQE6</accession>
    <name>A0A1Q5UQE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="6690" checksum="398EC30E137AA4AE" modified="2017-04-12" version="1">MSHLPETELKYLSCSAMFANLPQVVQHPWYPTPASLHDAYRAARGGSGSGKVGKLAVTCVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQF2</accession>
    <name>A0A1Q5UQF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="13396" checksum="E0FBFB7415EB861C" modified="2017-04-12" version="1">MPFEIPGAVLLTATSISVLRQAANDVFNRINSDTSYSNQFIIVSNISQPLQEQLSGDRNPLELPYRLTLDAQRQQAVIRIMPSGAYERLTQSFTGELIESYSKSLQLKRGYPVPRKSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR92</accession>
    <name>A0A1Q5UR92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR92"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR92"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044421" evidence="5">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="254"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="410" mass="45413" checksum="49B9313E11462229" modified="2017-04-12" version="1">MRFQSLALVGLLSGSALAVPRASKRSDPENSGQPINNENGRGAPLLGGTNKAVDLQNPDQLRTPTTDNGFVPNVKWSFSQSQTRLFPGGWSREQVIQDLPQSHDIAGAQQHLKKGATRELHWHRVAEWGFVYNGSLLLTGVDENGGFTTEVLETGDIWYFPKGVAHNVQGLDDENEYLLAFDDGDFEKIGTTFMVDDWIAHTPKDILAKNFGVNASVFDNVPAKFPYILNGTVSKDLEKAPEGTLKGNSSYVYHTYKHPSEPVPGHGGTFRKIDSTNFPISKTIAAAVVELEPKGLRELHWHPNAEEWLYFHHGNARATVFLGDSKARTFDFTAGDTAVFPDNSGHYIENTSETEKLIWIELYKSDRVADISLAQWLALTPADTVANVLKVDIEVIHQIKKQKQILLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URC9</accession>
    <name>A0A1Q5URC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FAM50-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URC9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URC9"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="190"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="370" mass="40910" checksum="0166572C50620145" modified="2017-04-12" version="1">MESSEQDSRTSTPRSFTGQTVSAEDMLKSQTVGLVHLSDFRKRRAEVLEQKEREAHDKSLGRLASGNSRSATPSAGEITDGSSTPRSDAPPKKKKKKALVKSKLSFGDDHDDTGEDSAATPRDSSVSRSGSKTPVDDGAMSAAAVRRMKANPNAPPPPKAMTKAAMEAEAQARDTLRKEFLAMQESVKNTEIAVPFVFFDGTSIPAGSVKMKKGDHIWLFLDRCRKVGAELGVGGANGASKARKEWARISVDDLMLVKGDVIVPHHYEFYYFIANRIPSYSKAGGLLFNYSDKPAPAKSNDDDPLYRPSDHKLEGADYDATETKVVDRRWYEKNKHIYPASLWNEYEPGKEFEEKMTSTRRDALGNTFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNJ2</accession>
    <name>A0A1Q5SNJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-hydroxytryprostatin B O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="164" mass="18551" checksum="408144F43D1012A3" modified="2017-04-12" version="1">MSAQEYPSLHFVVQDLSEQMLSQARDEGVSGRVTFQRHNFFDPQPVHDASAFLLRQCLHNYNDLDAIKITRAIVPALEKCAPGTPLLLNEVILPESGSTAHHIEHHLRQVDVTMMVVLGAKQRSRSEFERLLKQADPRYEVVRTFDNPMGVGLLEVHLKASLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQR3</accession>
    <name>A0A1Q5SQR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_13443</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQR3"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF4">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO90310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="40371" checksum="627DC7C19E3C74BE" modified="2017-04-12" version="1">MAQTHNILVLPGDGIGPEVMTEAIKVLKAFESPDHKFNLRQELIGGCSIDATGKSITEEVKQAALASDAVLFAAVGGPKWDNARRGLDGPEGGLLQLRKAMDIYANLRPCSSSSPSASIAKEFSPFRHEVLFGSEKDGTSEGVDFVVVRENCGGAYFGRKVEDPTYAMDEWGYSEAEIQRVTRLAAEVALRHNPPWPVISLDKANVLASSRLWRRVVEKTMTTEYPQLKLVHQLADSASLILATNPRSLNGVILADNTFGDMISDQAGSIVGTLGVLPSASLNGLPGDKTLNKRPYGLYEPTHGSAPTIAGKNIANPVAMILCVALMFRYSLNMEDEARHLEDAVRNVLDKGLRTPDLGGTMGTKELGDAIVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ST55</accession>
    <name>A0A1Q5ST55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ST55"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ST55"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="44500" checksum="C6169B52E92D88CF" modified="2017-04-12" version="1">MSQWLLPSTGRLSLKVSVNIGSEFQPPEWLLEKFDAIEEKEMKKQLQDKMKHARRALELKRMRLEELATLLKGTEKVTLPKKPKEIQAKLMNSLKGVRLVEVVELEKQLNEMDLVQLAKLLEKMKNVGLATLLKNMTLKELVEVAKQLEEVKLKQLAKLLKQMRQVNADRQMQSASKFEISLSNLLSKPEFTWILCSLTFPGKNEVAVIDVKSHIVCVDMVSRKDTISFSLTQESIESLSKIYGDNYLTGWDKRNLEAMRAVFEKSCSEFMYYTDASVLQGLQRNGCSKLPANKMKAAEEKILSLLETPHAQSMARNTKAINNYQIGEVAFPTSSPYAALDCYHPTATYDAGMQTLYWPPATTKPVEVFADRYQTFEGELRRDFNCMARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVY5</accession>
    <name>A0A1Q5SVY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fluconazole resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVY5"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO92056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="361" mass="40197" checksum="196296980BE3F2C6" modified="2017-04-12" version="1">MTWQPKLRPKGFPHSLDDFAVASLSELEHRSRTGDEKRDQRVFRVKRKHVLKACDRCRVKKTKCDGKQPCNRCSVHNHPCLFRERKATQTKVYSRGFVEMLESHHSLVVKALQKLYKFCINKEDFPGEPLAKAPDGHPLTHAILDRLGLIKQAEENADEPDEDSEDLRYLRLLSTSTECSATAEPSPEPTTPPEPSPTTLSSSRPSICNSLLTPMTSRSNSNWQWDLQSVQQASYSYPDNGYHQGLLAVQQRPSITSADLNAGEISPHVDIPSASAIAHNPQPHEQQSFAYFLDAGCNASSAGSSVEAKTAVRLQTGVMQDTHSDHPMSELSSDLLSDFQFSTHEPSLYPGFTPGWSFPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWB5</accession>
    <name>A0A1Q5SWB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase family member 3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWB5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="515"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="611" mass="66725" checksum="C82B599EE0B88DCD" modified="2017-04-12" version="1">MSGRNFVSRLGRPSLRVSSARLYPSAQIVHARLFSTAKRLFTQLPNTHIFRAIKDHDPASLAVVHSLSGRSFTYGNLTADVLRAKEDLLRKAGQTKGKLSGERIAFMAENSYDYVVMLLAIFGCDAIALPLSPSFPTGELQYILDNSEAKVLLATEKYANKAQDILQAGLQHDPLFDIRQKLVVGGSGNESVSLKDSKSSLELPAGGMMLYTSGTTARPKGVFIPERALTAQATSLLEAWKYSPQDRLLHLLPLHHIHGVVNAIITPLFAGSSIEFMYPFNTDQVWNRLAAPFLPSNSPQKSKITFLTAVPTVYNRLRISFPSLPQEIQAAGQKGISPENLRLNISGSAALPTPTKTAWQTLSNGNVLLERFGMTEVGMALSCGLDFTDRVDGSVGWPLPQVEARLVDTETNEVIPLGEEVDAQGRERVGEIQLRGPTIFKEYWGNEKATRESFVDGGDGGEHWFCTGDVATRRIVPGAGKGTSGDWARGPMYFIQGRKSVDIIKTGGEKVSALEVERELLSLPQIAEAAVVALPSEQWGSKVAAIVVLHPDAHTTGRNGVSWGPMDMRRALKDRLAGYKIPQEMKVLDTIPRNAMGKVNKKALVKQVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SX63</accession>
    <name>A0A1Q5SX63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">monoamine oxidase</fullName>
            <ecNumber evidence="2">1.4.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.4" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SX63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SX63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="4">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="199" mass="21846" checksum="E3F7491492AC8E37" modified="2017-04-12" version="1">MAGPVAKELDSDSLHEYCLQEFQSEQIATLLNTVSQSLVGIESKDISALSFLHSCKSGTGFQAVISDTKHGAQYLRVQQGTQTISKNIAKELKEGSLWLSTPFRSAFEKVVLESGKLEIPEPINALEYEWSKQEFFLGSPCPASPPRLMSAASGDALRKPFENVHFVGIETALEWKGYMEGAIRSGDRGTAEVIAALWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXN2</accession>
    <name>A0A1Q5SXN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXN2"/>
    <dbReference type="OrthoDB" id="3912356at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="55451" checksum="A377BA76D0027EB5" modified="2017-04-12" version="1">MSAESPGHKPGIRSFFSNALRSKKSRQTLRKNSLSRSMTDLRLAARSSADEPPPPMPDLAPLQAHRLKYAQAHVQLDSQLGERRDYTTMLHSLGLLEPDDSYGPAQVENERRQPGEGDIAKLSPGVWKYIASFLNPADAASLAFASITLFRRLGTRSFVALERPENADHRLNFLIGLDKSLPHHLLCFPCARYHRRTQEGQERIKPAHVINPLFDCPNVRNALNPQPKSRITHGRTIPFTFVQLTMRAFRFGPQYGIQPEDLGRRWTRDGWSFTSRFYIHEGRLLMRVISQTFAAPALTPSAQRLLLYSREDYWPYFSACAHWRDGELMPVCKCALEHIPRPRETAGLQGLEHKVKDRWQGGRYDPNALTSLCGFCRPMRRCPQCPSEYLIEVKLSEDKSDPRGMVFRQAIVVTRWSDLGDGTTPAGLEWGAVNGLRDDYDSFAHKHYAKRGIASIFEAAFTADTLPGQRVISMNPKKKKLGESGHGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SY65</accession>
    <name>A0A1Q5SY65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000735">
        <property type="protein sequence ID" value="OKO92958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SY65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SY65"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012615001" evidence="2">
        <location>
            <begin position="21"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="732" mass="86199" checksum="1176F10E1C814525" modified="2017-04-12" version="1">MALHALVTLLWRRCCLDSYAEWIGQQDPPESPRPKQQFYPISLLHDSGSLTLETHRSSPQRQGGLLYTQLYSSVKEVFAAGDVYPFSNPSLETLALDPQLRKTWQYVGGGLSHDLIALMRAYLNMKQRCHAALQGSFMKVFGLREEHRVSFRLFYAIDQELRERNLHQSRLPGFSSDVEPFYSLPTSSLLFWFHWNINKFCVGFESVYSINDRHFVTWEHTRIMMMFLRCLQFSYAGGLLQRVSGCWRDVWFRPDARRTDGLRRCEGLGFQRNMEEYGYAWFLDKVNWDTMTFRQPSAQYMMFNSPSMQEAFHARYAQIRDVRLDFLRVHQAHRWMEEFSSVSPCLDVLEDFLRQLSLCVFRKDVFLQVKRLLHPDHAPRALAGEVPLSYDSITDVFVEGAKPLQLLDQRRIAVKSVDTIFAWLWEWKDGRYDRKGWKDKPYRMVYQQSFEAINQIMGKDRAREWKKALKTSFLQSHWLIPYPHNNGFMRKSKDTGQEVWWSNFNAGLYEHYRQWYGVSRVGDLFPAEYIKHHPTTGWGRSYGEPQYMENAVDPEMELVQLPEGEFYEKLLHIADRFSQNPDAPMWKRKAPPTVFDFGITIGDDSLLRAQRKVKGTPVQGLCMQIIQALDEYEVLGHSGRILRPRKQLRRHGQSTTNENEDEVTSDEESIDNRRDRLTTQILELEPKMREAVTAEREQYRWPHLHGIHLKHLEPRLQRLKTAESKTGDFCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T078</accession>
    <name>A0A1Q5T078_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="15">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_11957</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T078"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T078"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012276401" description="glucan 1,3-beta-glucosidase" evidence="19">
        <location>
            <begin position="26"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="20">
        <location>
            <begin position="82"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO93678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="44991" checksum="C7242A4DA2136DC7" modified="2017-04-12" version="1">MSSLFLKKSLLGLSLVAALASPAVGIAFDYGSEKVRGVNIGGWLVLEPWITPSVFDNVGDAAVDEWSLCATLGPDQCRQVLSEHWNSFITQEDFNQIAAAGMNHVRIPIGYWAVEHLEGDPYVDGQLQYLDSAVGWARAAGLKVMVDLHGAPGSQNGFDNSGKRGAITWQQGDTVDSTKNVLRTLAARYGGDADVVTAIEALNEPSIPGGVNEDGLKQYYYDSWGVAREATQDTTVVLHDGFVPTESWNGFMSESTGFYYVMMDTHHYEVFDNGLLAMNTASHVGNTCSFVNDHVLHTDKWTVVGEWTGAMTDCAKYLNGKGIGSRYDGTYQGSTALGSCDGKAVGNIDTLTGDERTNIRQFIEGQLDAYEKGNGWLYWTWKTEGAPEWDMQMQLAGGVFPNPVTSRQFPGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T094</accession>
    <name>A0A1Q5T094_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vanillin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T094"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T094"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07105">
        <property type="entry name" value="ALDH_SaliADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO93664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="50573" checksum="3D73E2A5F4AE4134" modified="2017-04-12" version="1">MAQNVIPLIINNESVVTDIKFEVHAPATGELSSYCAGASVDDAVRAVDSAKAAFPAWSKTKAYDRRDILLKAAEIMISRKEELIAYQQEETGAGRPFSEHTFNMGVNFIKDFAARISTIEGVVPSVTLDGEGAMVYKEPYGVILSIAPWNAPFILGTRAVALPLAAGNTVVLKGSELSPKCFWALGDIFRQAGLPDGCLNVVFHQVSDAAAVTTALIAHPAVRKVNFTGSTNVGSIIASTAGKHIKPVLLELGGKASAVVLDDADLDKAAMSCALGSFMHSGQICMSTERIVVQRSIADQFRQKVAENSEKLFGKDAPALCLVNAAAVTKNKKLVSDAVSRGAKILFGDANANESVDTCMRPIIVDGVTKEMDLFATESFGPTVSLIVVDTEDEAIAVANDTEYGLTAAVYTQNLFRGLRVAKQIESGAVHINALTVHDEPTLPHGGWKSSGFGRFGGVAGYDEFLQTKTVTWME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0B9</accession>
    <name>A0A1Q5T0B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase RDL1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0B9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0B9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="114"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="226" mass="24411" checksum="96412E588A3944D0" modified="2017-04-12" version="1">MAASLHSASRRSVATIASTALRAPARQTIAVTSALQRGALSAANRGLSSTSQSRRSLVPCQSRSHIAPSLRQQVRWNSHEPSSVFREWGFEDLTNTFTTTQINASLPSSTPSPSHTPVILIDVREPAELTGTGIIPTAINIPLASQPDALYLTADEFETRFGFPKPSADGEQQIVFYCKAGVRARAAAQLAVQAGYNAEQLGVYDGSWLDWERQGGKTERWEGDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0E2</accession>
    <name>A0A1Q5T0E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0E2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0E2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="91" mass="10142" checksum="C6395B91040CA79C" modified="2017-04-12" version="1">MADKLRTLQNLEALQARYIGTGHADTTKYEWLSNIKRDSCASYIGHNPLLSYMAVGMGEPKEKTRTKMLEKMVRGAGNPPEVCARMRPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0I7</accession>
    <name>A0A1Q5T0I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0I7"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="1">
        <location>
            <begin position="59"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="468" mass="53721" checksum="A87F91F3B1CDED65" modified="2017-04-12" version="1">MASLLLSSRSEILSVIFAHLEPTDHLALGLTHRNLHPLVDSILYSRIEWEWKGPWNPLIIRFLRSITQRPQLAQYVKVVILKGSNVEYHLRGDRSQSPKIAVTEDDLKPLIECVARTNVSYRGEWIQELRSGTIDAFVALLLSQVPRLNTLYLGEDFTLQSLFVGRVLRSSLCAKGGYFHSFQNLREVSMSYFHFEFDKEHFRTTRNTADVLPLFYLPTVERIRAVIDNPASFEWPGACIPASQSLRLLDLTMVREGNLGKILSATPKLKSLTWDWYYSPDLHDDFHSDIIDLDQLATDLNHVRETLTYLRISASTDVVDLVRLPDAHIKGPFTLFSRLTRLKTLEVPIPFLFGFSKSDPNILGLEKLLPTGLEWLHLTDDLSYHSDWNWLREIDYLLSVISSWFLQGKRFTPYLRGVRFMLKNTLADDWPQEASPNFIDVGIQAPQAGLQFEVIEVLPSPESPDSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2C6</accession>
    <name>A0A1Q5T2C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2C6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14820" checksum="3A724EA99650E210" modified="2017-04-12" version="1">MTKQTTQAQWQVDKLWVKVMLYSKVGEEGIRGSWGKWGRSRREAPMVQSVIRRHKRTAFVPSQGENPIHEALTGLFSAHQCQPCLPGALGSELSTIGAHKGIYVPDRRGKSEKRNDKIYSKTGFQPTGLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2F3</accession>
    <name>A0A1Q5T2F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2F3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="21373" checksum="312AA45029912A58" modified="2017-04-12" version="1">MDPETFMHDRQTFRENLLTWANKLSADSTHDSIRMEIVSELEEMVKEKESTHVPDSCSGDEDHDYCEGYELNDPLAEAGFGRPCSKDGTIRDTLSWASELLKRRQVPVSDVAIILDMLALHIVRLRLTRISEGVVVDPYVDKMDDLARVRHESNQNHANEYLRAIWNRLYDCRDCNCDKCSGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2N7</accession>
    <name>A0A1Q5T2N7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2N7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2N7"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="304" mass="34789" checksum="779D10E5ECCAD101" modified="2017-04-12" version="1">MDVPPRNTSAAKCTIGKLRAWVICILAPEVTFVVAAFQLLDAKKLQKVCSKAQKARDAEISEPKTWLSQRSRPLEQVQNVDHLDLHQVHTEWTLPQCFCVVAGGLMLQTQDQWIYTIQPRDMKPLIQAGIVHCSDFRDQDIEDRTKADSFAKFFTVLQSTWFLCNIITRWACDLPVSPIELSTVAYVACGILIYGVWWYKPKDMGTSIAIHVRCNRDDLLIEVRNMIGNGWVHVRALVKEDNWMFVLWKNIRTPFLTRDVETLVEHYDTRDDDLNQTALETFIFDIVGSFTALLYCGIHVAASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4N5</accession>
    <name>A0A1Q5T4N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of nonsense transcripts 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4N5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4N5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="475"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="680"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="906"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1018"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO95182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1140" mass="129211" checksum="BD1C00E993232CA9" modified="2017-04-12" version="1" fragment="single">ELRDLNERAWEGETDVFPVSKSLDSALKKNTAFIKRLRTGISASALSTFLTDIRTLSLHKYLSEIISACYEGLCKLKSPGEIAAGVEIICALHQRFGPAEFTRQIGWLLGRGMSSMDKASLKALPQEMREREEKERLSRHRVLLRVVTELWLVGVLRTLDDTERPEDARKDATTGKLPDLVPMRAMKSAAALKELEKQAEPFPLEVLKDLLGHDRDHTNLPLAVLFVKSFSWDILGTKLVEDGRKTVEADGATSRSTGAEQENAEGNADATAEAEPPLVPEKTQQRFRNILSRYLDDVKAHVVRDQKALASQSRRNAEAYVKSGEIFEDRQSNFEKQSKTLEKLVANTQVLCEALGAEMPDLVEKEAADAGGSGGIGLVKTTDYLRGQGDGAGIWEDEEERRFYENLVDLKGKVPAVLLEDGKKKKGEGEETGKKKAEGDSETAAEKPEPSEDRAAADADDQSMAIASKTVGAQVDALLGKLPELQTKDQVDQFALDFCFVNSKASRNRLVKAVSDIPKGRIDLLPLYSRLVATLGQYLPDIPQGLTTYLDEEFRSLQRRKSKEFLGQVRMSNVRYLAELTKFGVVPEHIIFHCFRVSLDDFSRMNIEIIGNLLENCGRYLLRNPETSPRMASFLETLSRKKTVQHLAQQERMVIENAIYYVDPPPRPAIQQKERTPVEQYIRRLIYLDMNKRNYTKILKTIRKLHWEEQEIVDILERVFSKPVKVKYGSIHLLAILVSALYRYHQGFVIGIVDNVLEQITLGLELNDFKFNQKRIAEVKYLGELYNYKMIDSPVIFDTLYRIITFGHESGTPVPGKISPLDTPDDFFRLRLACTLLDTCGHCFDRGSAKKKLDFFLTFFQYYLFTKDPLPMDVDFLVQDTYSSLRPQWKLATDPEEATRIFSDAVAQNYNVPDSERPVELDEEDAESSSSDEGLEDDAMPEIEDEQESSDEAEASGPYIDANDESDFEDEHIVVTRQEEERDPEVEADFDREFEKMMAESMDSRRFERKGVFDIPLPMKRVLRENPATESSTESPTPEPMPTKTMAFSLMTKKGNKQQTRTIDLPSDSSFAVAMRSQQQADREEQQRIKNLVLNYEAANEPEVAESFEKRIPANQRVDKSGANRSAFRSRKLQLSDVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Z7</accession>
    <name>A0A1Q5T4Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000704">
        <property type="protein sequence ID" value="OKO95294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Z7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4Z7"/>
    <dbReference type="OrthoDB" id="3067443at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024498">
        <property type="entry name" value="DUF2786"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055592">
        <property type="entry name" value="DUF7168"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10979">
        <property type="entry name" value="DUF2786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23771">
        <property type="entry name" value="DUF7168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2786" evidence="2">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7168" evidence="3">
        <location>
            <begin position="105"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="406" mass="45687" checksum="88E1A07D649DE307" modified="2017-04-12" version="1">MPFTSSQAGRKRSDRKPMQKATVIETADQDQAPSTSAVDKKILERIRKCLDRAHHANSSELEAKAALFVSQKLMSQHNVTQADLLASDRSNSKASFGGHSKVRITKTNGSDKRVMMEAFAGKLANAMCTFFDCKCYSTYCGDCVEWSFFGIASNTVAAAMSFEMAHNRILNWACAYKGGKPTFSYRIGVADGLAAMANHEKQRELDQAWRKELDIFASQEHDEAENRRREIERLRLRPANYADPLSANGSDDEIVDQTNIKIELDISLCGEADDVNSNTKADFDMDDIKVTDLCDNVDEAIDMYVKREPTEPPNPTEMPLFNMDSKAHIDTKTGAPPATEASPWETGAQLIRFRATAEQVAEDYLKEKKIKLSQGRQRYYMIRDFDAYRQGQADSAMIEINRQIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5K0</accession>
    <name>A0A1Q5T5K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-arabinose 1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5K0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5K0"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="39680" checksum="EE13FBBC5014C7DC" modified="2017-04-12" version="1">MEKRRDCKLPEIIPPLILGGGGFNYQVNANPRSLPIRSIIKSAFELGFRAFDTSPYYGPSEELIGDALSQPAVTEKYPREEYILMTKVGRISAEEFNYSPTWVEYSVRRSLQRLQTSYLDIVFCHDVEFVTENDVMGALGVLYRLVAQGLIRYVGISGYRLDVLVKLSRSARELYGRPLDIVQSWAQLTLQNTRLLSDDEGLQALLNEGVSCVCNSSPLAIGLLRSGGVPQGSLGDFHPAPAELRYLAQQAAEWVEAHGESLSALSMRFSISQALLASSESFRVSTITGVSSELELTENVAAARQVFGHKVSKLNSTFERSGSPFTFLLPQSLQLKLDQPLYEGVQKILHQWLGYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6K4</accession>
    <name>A0A1Q5T6K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6K4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6K4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF1">
        <property type="entry name" value="DUF2421 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="749"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="6">
        <location>
            <begin position="695"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117551" checksum="950B4411E68A04BD" modified="2017-04-12" version="1">MAPSETEGAPSSSRRLLRPKVCTRSALAVNNTQLEAKKINQSPQVQLRQATFVLPRTGQRLKGLVSLRDPTRRLATDDDDEAREERRGLLSGQIETHHDGYGTWLSKQAQELWAGLHRFVISEQGIGVLKCSLAYLLGSMATFIPALSAFLGHQDGKHMVATVTVYFHPARSQGSMYRALICALLAFCYSAFLSITSMLVENFFQDSLDLPALGHAVVLIVFCGGGLGFVGWTKQRLGDPLVNVACSLTALSTITVLTKEGAVQSGDLSLNKIIQVLKMVIMGVIFAGAVSFLIFPISARKKLRANLVTTTDTLAVMLGIITESFLSGSEDELKSAEFIEAETKHRKAYGQLDKLVREAKLEHYFAGTEREYRLEKKLVRWVQDITHNMGGLRSAASLQFSLIRETLARESQESGGQESAVPTEYLASLERSWSFPDGSFLEPIDERPEEELFPSGGFSTPNSDGKLEPAKHPLLPADVFTIFISHLGPAMRSLAFTLKGIFNEIPFGPAPNYKVSVDSRLRTSLDRALDLYQESREKTLKSLYQQIETIKLRTHEAEADLEEVSASCGHFSFSLLEFGEQLHELLAVLDQLQLETEERPGGRSWSWLRFWKAKDTNPADEPTFLAPPRPDARVSPAVRARLYPGAETTVKQRLGYRLWKSLKWLRRDDTRYAIKVGAGAALYALPAFLPSTRPFYQHWRGEWGLLSYMLVCSMTIGASNTTGYARFLGTCLGAVCAISAWYISSGNAYGLAIFGWVMAVWISYITIVQGNGPLGRFIMLTYNLSVLYAYSLTQKEADGSKDEGGQEPVIGEIALHRVVAVFSGCIWGIIITRVIWPISARSRLKDSLSMLWLRLGLVWKRDPLSAMVKTKRSVVYMTAREKLELERALSRLETLLVSAGSEFELRSAFADDTYASIIRRTRSMVNAFHAMNLELMKSEIATEGEISLLRYTAQERQQLSARISHLLTVMASSMKLEYPLSDVLPSVDHARDRLLARIYRYRQDQEVSLLTTDEDSSLLYAYILVTGQLSKEISEILADIGQLFGVLSEDVLQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6K6</accession>
    <name>A0A1Q5T6K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6K6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6K6"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="452"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO95861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="771" mass="83488" checksum="FD7F7A0BFE05311D" modified="2017-04-12" version="1">MDPTSTPRHPDRFRMGAGAEDPIPSSSPAFATPARPFRMPRGHAPPTKTSILPILLPPATLRPVAFRTFTRKHNLTISSSALQTLAVFIGKNCGSGWREEGLAEKALDEVAKIWKRAGGGVIVEEGKGASLKAILQTLESSMSGGRVVAGKGNSQDGKSSGLGVDAGRMDTSNDHSQGSLTMRAGDVDEDESKLSCHSRHWLKVVDAFDLPRLTYNVDKKYFEALKSKPTLFPPPSHKTALFRDRYNLVYQRLLRNESFQSSLGVAGMPSLQRSSSNLGMQQSYKLTPIANLLGRSGTSHLLLGLLSISPTGDLSLVDLTGTVALDLSHARMIPEDGAWFAPGMIVLVDGIYEEEEMVQGSMLGGNHGVGGAIGGHFVGVSICGPPCERRDISLGTGSRQASGDVSSSGGFGWVDFLGTGSERAQGARMRRLQEKCLRGAPESTESTARLKVAILNEVNLDNMKTLDALRKVFSTYNDLALCERPQTFVLIGNFVQKAIINGGGRAGSIEYKEYFDSLAVVLADFPALLQHSTFVFVPGDNDPWASSFSTGAASTIPRQPIPELFTSRIRRAFATANSELDRTQTSEPAGEALWTSNPTRLSWFGPVHDIAIFRDDISGRLRRTAINMHKDEEEAETTDPMQETLDEATNEAVSFAPDLDQQNGSKSNGASSAAASMARKLVKTILDQGTMAPFPLQLRPVLWDHSSAVQLYPLPTALVLADAEAAPFCMTYEGCHVMNPGRLLPLGDGQAVKWIEFDVLRNRGRVKEERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9K8</accession>
    <name>A0A1Q5T9K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator xlnR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylanase regulator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9K8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9K8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="12">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO96932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1157" mass="126336" checksum="6958C4078F6972DC" modified="2017-04-12" version="1">MSTTSTSLQSFANSYSPFSSRPQPNRMAQSQTPGLDTLAEGSQYALEQLQLARQASASNPPTDSEGKPVSESEALEPPSYREQNGPHSGGKSSSSQHDPLVDARSAIRKNSTAAAVRRRISRACDQCNQLRTKCDGQQPCAHCIEFGLSCEYARERKKRGKASKKDLAAAAAVATSTSDKGLQDGGSVHGNSPNGQNSHEVNMPYDPAFDAARAVPESAQPPLRNHSVPGISRIPQNNHPAASHPQQSVGSGIDSISLNYGNVPDSNRPSMSVPDLRSLQMMQQNGNPRSPAAMIHSQGFGSGYHDGAYSLMNSHDQNANSIGQFRLGGSAENPSASFLGGFSPPAQSPSWLPLPSPSPANFPSFSMAPFASSLRYPVLQPVLPHIASIIPQSLACDLLDVYFTSSSSSHMSPLSPYVVGFVFRKQSFLHPTKPRVCSPGLLASMLWVAAQTSEAAFLTSPPSARGRVCQKLLELTIGLLRPLIHGPATGEASPNYAANMVINGVALGGFGVSMDQLGAQSSATGAVDDVATYVHLATVVSASEYKAASMRWWTAAWSLARELKLGRELPPNANNRQDGELEGESDMDLNGNKRQPSSLLNSMGHGPGSSSVNLSEEEREERRRIWWLLYVMDRHLALCYNRPLTLLDKECEGLLQPMNDDLWQAGDFSAASYRRAGPAFECTSHSTFGYFLPLMSILGEIVDLQHARNHPRFGLHFRNSGEWESQAMEITRQLDVYAQSLKEFEARYTSSLALGGDNDTAMEGAHINHVSPSGRSNSSTVGSHVNESIVHTRMVVAYGTHIMHVLHILLAGKWDPINLLDDNDLWISSDSFITAMGHAVSAAEAASDILEYDPDLSFMPFFFGIYLLQGSFLLLLTADKLQGDASPSVVRACETIVRAHEACVVTLNTEYQDIAHQRNGFDLTPEELAEWYIKLQQEGNVHNINLVTPEHVVPQVVLSILAARDMGLRIPIIYNTSSYDSLDSLKLLDGLVDIYLPDFKVWKESTSKRLLKADDYTATAMESIKEMHRQVGDLSFTSDGIAKKGVLLRHLVMPGKQDEGREIMRWLAENVSRDLYVHIMEQYHPDAHVGKKRRVTRKVRMGEGEGDGGKSGQEEVKYAEINRAVSDEELGSVRDAAVKAGLWRFCEVNEQNSAFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9N5</accession>
    <name>A0A1Q5T9N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9N5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9N5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="363" mass="40643" checksum="C7A9DF87981EF20C" modified="2017-04-12" version="1">MPRTLPWLFNQGNDVQVKRESTPRKRVKRERTPEAHDDVTPRKPPTSPEKRDFFRFLIEGLDHDDAWIMVEDEFYTIAQSFAQHLHYAEYIRRKKEAKAQSMEALNEIQRPTDGRTKLPKEAERRKEAEALAARQKAGLAHLGEPEADKDDSNDDDTWAGTHLHGLMTSPRKSRLLMGAHAMKSSTRAAAGFSQAAGAYSDRAAASVPLSRAAAAHIVEVHDVTTSDDDGDIDGETASDEDDDLDGQARPVRIQSKSLPTNGPTRTAQPQHTTGSRNGIHKQPTIKEEKVRVNPKPTSRFQSRVQMLFDDFDELPEPSPSKTSSTSDMKKSRSSTNIITQRGSGDDNLESKKTRFNDVPTFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9U8</accession>
    <name>A0A1Q5T9U8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9U8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9U8"/>
    <dbReference type="OrthoDB" id="1179585at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012705274" description="rhamnogalacturonan endolyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="318"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="11">
        <location>
            <begin position="410"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO96948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="570" mass="63188" checksum="EE8ABA12A57244B8" modified="2017-04-12" version="1">MKGLFAAAASLLLSTVKALPSKPATGPFLTQVDNTTWVLGNEIWNVTQEQIYGVKLMYKGKDCVGEAVGHYVSYNGAASNLQWTSASISSRGTHQGKQYIDVSFTAAEGDMHWVIFSGLSGAYQYFVNHALPTLGEFRTLWRLDNSTFTKGRTNIKDEELPPLSEYLATNKVQDETWLKPDGSGYITKYDFTAWSRNQDFFGVYGDGFGSWYINAGKDYYNGNHLKQELMVHRESSTGDAVQLNMIHGTHFMASSSDVFPDGKMWGPWLWYLNDGDKKDAAKRAAEEFKSWPYAWLDDEDYHSRGVVQGKIMLSDGRPASNAAVFLGDNNPNKTALDMGSTYYYTAYADKHGNFEFSDVRAATYGLQAWSNGSSIADVTTSFLQNDVTVKKSSKTNLGSLTWQVSSKKQVFQIGDFDRYSYGFLHGGAPHEHALVASCPANLTYTIGESKPIDWCFGQTYKGNWTVRFKASSVPESAAPNLIVSLAGYSSGASTNILANGVQVGNMTSGSSLIPTDPCLYRSATGAGEWHLLEYSFDKGLLTEGWNEITFNMVRNTTWHGFMWDSVVLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAT0</accession>
    <name>A0A1Q5TAT0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAT0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAT0"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="488" mass="52644" checksum="471C5ACAD55C1A17" modified="2017-04-12" version="1">MTITQNPKVKSFETRLFINGKFVDASDGGKFDLISPTTNEKFAEVSEATEEDANAAVAAAKAAFPAWSALSPSERGVYFKKLAALIIESHDELAEIEALSMGRPVSGYFESYMAANSLNHYAESGHQALGTSSLNTPGFLNMTLRQPYGVVGAIIPWNVPVLFLINKSAPALMAGNTVVVKSSEKAPLTSAKVATLVEKAGFPPGVFNIISGHGHISGNVLSHHMDIRVISFTGSGRTGRLIQQASAKSNLKNVILELGGKSPAIIFPDANLERAVKETAYSIQWNSGQVCMANSRIYVHESIAPRFIELFQKGFANIRSGDPLLPSTNHGPQADGIQYKQVQAYIEEGKKTGKMVLGSEPSEHESGFFVQPTIFLETPEDSKIMKEEIFGPVVNINTFKDEDEVVAKANDTEYGLYAAVYTKDVSRALRMAKKLDSGSVGVNCTSPAGASDMPFGGYKASGVGREGWTVSMDNYLEVKTVLIRVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB33</accession>
    <name>A0A1Q5TB33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB33"/>
    <dbReference type="OrthoDB" id="4320633at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9391" checksum="ECFF1BB743458517" modified="2017-04-12" version="1">MVNTSVSSDYSVEEITQVGRKGRSHGHKYDGADFDESMTNPRTTRNKQERRRSPTTSNKARASSGSASKRRTASKNVHSHQPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBD6</accession>
    <name>A0A1Q5TBD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBD6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBD6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="30076" checksum="134B4B3C6C055698" modified="2017-04-12" version="1">MLHLETIDLARIVAGDSHERQKLKEAATRPGGLLLDFKNTDATILDTVSRLYDLSDRYFQRPSEVKLKDVREDIPPSSDRGYKSSDCDETFEFADDELLRGDLSLPPILDEERDLVRQFNELCHAATISLLSSLSDSLSLEGDKRFETHHRTTDSSETGLKLICEPSLAKAADVVENKHTDSGTFTLLFYERVGLHVYLPEEDRWDFAPVPPPGCALVTVADSLQRLSQGQFHSPLHRVTQPVDGAEKRYYLSYFLRPSHAAKAGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBK1</accession>
    <name>A0A1Q5TBK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000691">
        <property type="protein sequence ID" value="OKO97593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="652" mass="71020" checksum="3E0700C2DF230CE2" modified="2017-04-12" version="1" fragment="single">MLRASKGVGPAPGASGGPLKNLPSNRERVLNANHAAHDLLKELGRGQNTARPAPKVVNFLRQVEDLTKDLLSTPLTDWQQELEALRRDLKQEITTAIKAAAEPPARQTVRSFAEMVRTMPAPAHYLSSSSSSSSPTRPAEVARDREVVVCLGDRSQVSAFRRLTSAELTKRANQARAKAARSTDTAPLASVMVLASRQLKSGDLRFTMRDAREAEVMRIHREKWTKGLCRTAFVHMPTWGVIVHDVNVRSLGINKASEALPQEKIIKDLLAANNHNWGKEADIAKVSWLRIPSGKSGSLLVEFTSPVPATIDKGVLWDCDSLTAVLYDRAARVRQCFNCQQYGHIGSTCANNGRCVYCAEGHQSRDCPSKDTQENKCANCEGAHAAWSTECEARRREVERVGELSKYRGRYHHVPAPYSINRPPPTLHSSSASSWGTPRDSSSSEELTSGVESSGLAPAARPSNGGKGTGPTPASRTGTGLQASQHATNKSDKSVTTASSGRRSRGRPRKAQRLEPQPMETSEDEASPTGCPQEQPIVLDQPTFQFSTEPSAFQFSAGSTFAPPPADTINFQPEGSSSQTTSTQSRAEKARARTAKAREARARKAAERKTSNNTDGTRKSARITELAEEANQERLESELSSELDEVNMRDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC25</accession>
    <name>A0A1Q5TC25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000684">
        <property type="protein sequence ID" value="OKO97730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="18172" checksum="DC537980E26DB360" modified="2017-04-12" version="1" fragment="single">PSILKYNIQHXNSNLLHLAARDNDYARAELMLLYGANANTFLRGKTPLMRAIQHGSIDVLELLLSHQKIDLLIQNREGESALTYAVKYGTCAGKGRLVNPQLDNKIRHEHDRTVPPVAICTGHIGFLPWLWIPFNDLRVKRGRDYRLKDWVRRAKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCC2</accession>
    <name>A0A1Q5TCC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCC2"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="57"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="52634" checksum="4049A3D509892F27" modified="2017-04-12" version="1">MAEPISDHNLKATDSEASIHLEDVCPSPPIPLSEDGHPSNHSHQDPGNWPQWKKNAQILMVAFHSCVSTFMAAGIIPAYDLFAEEYGVTVPDASYLTSFQILLLGLSPLLWNPVTAVYGRYHISMFSVLGSMVCNIGGARCTTYGAQMATRVLTAFLISPPIGNGSGVVTDLCEPEKRAQKLGWWTLMTTIGTPLGPFLMGFVTKHLGIQWIFWVFAIINFCQFLLYIAIGDETIYNPKNERKQSGFFGKLIPRKITSHSLSPRDFVAPFSLAMTPRVLIAACAHAIAFCYGNIAMIVEMPIAFGQKFHFDAQQIGLQFIAIIIGCVLGEQVSGPMCDWFLKRVRQSRGYSCPADRLWLSYIAFSTIFAGLLVWGFQLQHATTWNVTPCVGAAIASFGNQMQTTILTTFAVESKKERSAEVGVFVNVCRQIYGFIGPFYLPHMFTALGFGGASGVMVAIVGGCAMVPIIAVQFVATKSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCT7</accession>
    <name>A0A1Q5TCT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCT7"/>
    <dbReference type="OrthoDB" id="5397734at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="2">
        <location>
            <begin position="352"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="780" mass="87672" checksum="D286AB0FC4835B56" modified="2017-04-12" version="1">MARRRQVRRNRPHKFPRVSWDTYKRQVLCCLYRFFDCSNDQLSDLFSQIFRTHLRDRGFGNKNVPYGTLNAQWRWIRGNKLPVWYHVHVVTDFRTNGEWKEIIHLIRLTAFELGILLNEKLSDMTIISDGDFDVNNDASEFLTSVLLTRPIRPQDAGSVNDHADACVHSSVETTDDFDGHHSGNAHLDSSAASASLVDGFSSNASPSAFVLSPETPTTDFNQLTPTSYLRIERVRDNTPTPQSRAMAESTLADCHITPDSGRNSEPLVTSHGKVCLWCEIEGAEPHDGTPTEEPNVNVGENRETFNQRINELAEPANPPDIQLAGSLDASIEGLNDLRQFWELPGPCGVDNLPHLLYRWSNTNSQGINSETLFVAGWFTDTYPDVGSPGQMSETDFLSVFAAHVTRVQVPTPFISAFARPLAPIHRAVRNRQNAKVSIIDPRKLATPVFYAKPLAQITRTTVKRWKGYGEYAIWGYAPSEAIICTFDIAALEDIVSWDHEIQNFLQLHLFNGQVTCHRALRRDLCTNLRECSYKTSRCRLRRLAFYLGLPEEYHEYFAKDIHDAWTMDFGPAYEGREKLQEPGTLPARNVSDEVDDLNRVMRCNSESTTSYIPPRSDDGSCSESTSEEEDNLSQSPEAPCPRRDTLSPAFSVVSDSDDSVHVNMHRSRPRVVMMAEVAIPPTQPSTSRYFGRVGNINSVVPPLNLNLLNLSSSLNDDQYLSEGAEWPSDDGTLPGIDTPTQSRFFEQRDNDGASGRPAVSRFTIQGRNPLVLSDDDMVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCU6</accession>
    <name>A0A1Q5TCU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCU6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCU6"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="458" mass="51993" checksum="6D5565D1A956A4FF" modified="2017-04-12" version="1">MQIIWRESADTVTYEDARVGRVFNHRRPERFPLAVVRATCQEDIVAAVKLAVEKNCRIAVRSGGHSWAAWSVRDNSILIDLGNYKSMEVDAINKIARATPSMTGRELNSVLVKDHQLMFPGGHCPDVGLGGFLLQGGMGWNCRNWGWACERVQAVDVVTAKGELLHCNSEQNQDLYWAARGAGPGFPGVVTKFHLRLNSYPKNGFRSSGYIYPIEMYREALGWVISISPDFDNDTEIAAISHYPEGSDEMRLFILFVTMKNDASESEKALRAAQETRPAGCVEEWFCKEDSLEGQYDNQARANPEKHRYCADNAYIQNDADVPAVLEEAFTTLPHRKSFALWFAMNPCSRRKLPDMALSMQSDHYFALYTVWEDAHDDPRCQAWVRDVMKGVERHSVGAYLGDSDFQVRKTKFWADDNACRLMEIRRKWDPQGRICGYLDESDLSGTRGLDNAHQWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCX8</accession>
    <name>A0A1Q5TCX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCX8"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="31758" checksum="80F9A3C6C7063AEA" modified="2017-04-12" version="1">MAGTSYGGSASDQKLPKNTPSPGNGADSDEEEFHDARFPPEEEARLLKEAQDIKQEANQLFSSACYDQAISSYDRALSSCPNYLDYDVAVLRSNIAACYLKLEDWKAAIDAATASLDRLEKIIPTPPAHNEQRDGQQSNDAKASTQESGEVVELSATDPDAEEKQLALLKELDTQRTNVLRIRAKSLMRRAKAKSNLGGWANLQGAIEDYQALNTMETLPSDEKRIVQKALRELPSRVNEAKDKEIGEMMSKMKDLGNGILKPFGLSTDNFNFVQDPKTGGYSMNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCZ8</accession>
    <name>A0A1Q5TCZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000680">
        <property type="protein sequence ID" value="OKO98096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="12"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="32366" checksum="8C6395362167FEB3" modified="2017-04-12" version="1">MPPINRGILERRRVICYRQTFFSDQGAYMSMLPLVQERTGITHLILAAIHLNEQPGNITLNDDSPTNEKFGPLWVEVKKMKKTGLKIMGMLGGAARGSFERLDGNDGQFEAFYGPLLKMIKKYALNGLDLDTEEKMSLEGIIRLIDRLKSDLGDDFIITLAPVATALLDRGNLSGFDYRELEAERGSKINWYNVQFYNGRSFANAPNMYTDIVCRGWSAQRVVFGVLTNPNGGSGYVAPEVVQNMLSRLSRQYRYFGGVMGWEYYNAMPDKTKPWMWAKGMAGSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDD1</accession>
    <name>A0A1Q5TDD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acylphosphatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDD1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7320" checksum="A33605EEC2BE4B36" modified="2017-04-12" version="1">MTSKRVEGEVQGEEQTVQKLLQQIDKGPRHAHVVKLEKKELELQEGEDQFLVMRTAESMFHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDD9</accession>
    <name>A0A1Q5TDD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Karyogamy protein KAR9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDD9"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="957"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="111326" checksum="B54C49F11BEF5AE3" modified="2017-04-12" version="1">MHATVDGPTPSATDIAPSASVSVTSASPPPPAVSGSPNDPGPSPLRRLKSKSSLWSLGSSNHSGHEDDLTPAEPSSAEKAAGKPGIFRRLSPALAARVKLLDGTSKVTSAPRDPKNVGRIPEHQLKELDSQHQDLSIKVERRGQAWAGPIPTSPDQRPQYFKRSASNRLEIPGQDFVLRATEADAQGEDYADAIVDGPEPPALAAAREPVPVPDAQSSPPPTTPPMSVAEPVPAPLRVEPVSETEPPLPNNTAQDTRTDFEKYVEDTKRSAEQSAEAAPAPPPKDSPPNYTIASSSNSQSYFNPMGLQRAESIYSFSRASFSNQLSQLTSIPLPQPGALETSIGNIPTSLAAVRALNGAAEQIQIWIRKASDVLSGLDSEDDVEWAAAGGREGLDGVDKAITRFESLVNVYVKAIENVQLRDDIANVDTESLKTIVSQMESILQNWAQIKNKLRGVKEQVELAMEWEELWSNVLGDVGMEIDNLSGMIFEMEEKRHHTLMDTGDSTGGLDINELETIVEESPTKGRSPATNRLSMLAAASGTPVIKTPQDDSSYSNLMALFARMQPLRASLDFLPMRLSMFQSRAEGVFPSACEELDDRRTRLEKSYKVLETDAEALRKELGEDKWIIVFRNAGSQAQKMFESVERSISKLQEGLESNAQVLNPGNMTKRIENYEAKKMHYVPAIERVISIIQKGVNDRLTVNGEVLRLLSDMTSRTDALKASLRVMDASLEDVHIVKGQQLRDSISSIITMDSPATGSAIDTPGSSPASSVVMSGSGYKTPMGSSSRRESSVGSATTRSTMSKVRRLSGLPQVTATMTGRKSSIPKPTAPVTPTPATRKTSHIPQPSTIPNRPRWNASTNLNDLHSSSGYLSTTTPSTSMKSSAPALYGRPSSTVPFRRDMSASPAPGAGRSLSRLSNRLASSSRSPNRNVSSPTPPRSSLLDPPPYSRLRRPSGLSATPRSRQSFAGTGLSFSRSVSGPGHDPRESPSKSARPGTALGHSGSRRTSLLPLPKRSDKGPASQAKLDTRPRWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDE7</accession>
    <name>A0A1Q5TDE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein AAED1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDE7"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="28276" checksum="AE14ED1F7CD3A350" modified="2017-04-12" version="1">MSSTAEPVLVSYPPAPSNVNPSPPAESVPAADDVKVADTTKPHEVPSNDKPPSVDTIRKVENYPILDNKGEKHSFKSIYDGPDSTGRVLVIFIRHFFCGSCQEYIRALAASIKPDELLKLPIPTTFAIIGCGDHGLIDFYAKETGCPFPIYADEANTLYDDLGMATTWAFGAKPEYFRQSMARVVLGSITQGLKHLSSGLATKGGDTKRVGGEFLFEPSQDEGGKTISWCHRMTTTRDHTEVKELAKVLDKDGTVLLQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDG1</accession>
    <name>A0A1Q5TDG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDG1"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="157"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="543" mass="59418" checksum="687A97D0E5672D81" modified="2017-04-12" version="1">MSWQYKLASSVRASPRVIVTRPNARLLLRPTAGGAAGGFSAGSVSAMTQTTVAYAKRTLTTTQPRCLNIDNINPHIRAAKYAVRGELAVKAEEYRQRLADGDKSLPFDSVIFANIGNPQQLDQKPITFFRQVLSLVENPLLLENPEALKTSFGYKQDVIDRAQTLLANVQSVGAYSHSQGAPGIRKSVAKFIEERDGFAANPQDLFLTAGASSGVSTLLNVICNDSNAGVLVPIPQYPLYTATLALLNAQCVPYLLEEEKSWGTNVSAITQSIKEAKAAGTNVRAVVVINPGNPTGASLTADDIKKVIDVAAEEKLVVMADEVYQTNVFEGEFVSFKKRLRQLQKEQPGKYDAVELVSFHSTSKGMVGECGHRGGFFELVGFDPQVQEQIYKLVSIGLCPPVVAQCLLETMVNPPRAGDPSFELYEKEYNGIRDGLQKRAFALYDAFQRMEGVECQKPQGAMYLFPTINLPTKAIEAAQAEGRPADEFYCLKMLDATGVCAVPGSGFGQKEGTFHFRTTFLAPGTDWVERIVKFHSEFMNQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE52</accession>
    <name>A0A1Q5TE52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE52"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="32980" checksum="81D3C7687E5D01F8" modified="2017-04-12" version="1">MPEGLPIDNEQVLNGTMVGYAQQLVVCTGKRDWTSRIENDGKDRGWGNLVRGLKKMMGRGGPYLDPFNNILVTNSSLRPSPSTKSQSTASALLFPAFKYIPSIPTSIAPSSSTTSSTTTTLKTFIRAFLLPKHHHATQTTLPQSKLTALTRTPELQSTHFPGTIDILHSPTILICGHGGRDMRCGLMAPALETEFQRVLRGVGFDSVGSETEGAVGGVDGPNHANVGLISHVGGHKYAGNVIVYIPPKMTVRSGSGSTLHPLAGKGIWYGRVEPKHVQGIVDETVLGGRVVTDHFRGGIDRNGGILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE83</accession>
    <name>A0A1Q5TE83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c mitochondrial import factor CYC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE83"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE83"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="402" mass="44048" checksum="4A61A0C545889017" modified="2017-04-12" version="1">MKSSIHILRCRCSSSSGLRSTATRSHRYASTSSSSTSTSTSSSTTPSTPTPTTSPKRTRWLAITLVSIAAASAGAYIRTQTPSSATLNTETFTKYSLVSRVPISATSSLFTLRPRYPSSDNYDVYENAWRTGVWSVMFKQPQLQIGRDYTPLPTTAATSLSVDEENEGYLRFFIRKDPFGEVSRYLHTLEVGADIEMRGPQIECEIPKETREILFIAGGTGIAPALQAGYSLLNRTTTTNRPNIHIIWASRLRADCVGGVSDTPKVEASPSSRSWFSGWFGSSSSSKAHVESVALTSQGQESSLIVRELEALKSQYPGQITVDYYLDEENRFIGKNDLAEFIKPSKSVAGPQNRKLILVSGPEGFISYMAGPKVWAQGTELQGPLKGIIKELDPKGWAVWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF82</accession>
    <name>A0A1Q5TF82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Expansin-B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8806</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF82"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="2">
        <location>
            <begin position="21"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="3">
        <location>
            <begin position="175"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="278" mass="29681" checksum="FC5AE4F974B6D436" modified="2017-04-12" version="1">MLGSTCDAFCTAYPLLCKDPSNVTLRGNFAAPNGDYYTQFWPSLSAGAPGDPDNYLSCGECFELIRTKADGTDYAVGEAGYTDPIYLEIVDSCPCSANSKWCCGSGADHCGEINFKYGCPLPKDSHHMDLSDIAMGRLQGNGSLTDGVIPTRYRRVPCPKPGNAYVWLRDGGGAYYFALSVVNTNGVGSVTAVEVKSADSSTWVALEHDPNYTSSRPQERYGAWVLPHGAGPFALPVGIRVTSPDGQQIVNEAAISTFTAPATSVAGFYYIDLGVQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFG1</accession>
    <name>A0A1Q5TFG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFG1"/>
    <dbReference type="OrthoDB" id="4506255at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13675" checksum="C125003B9431066D" modified="2017-04-12" version="1">MANQEEMAQDTLESPVPFHGDPTSHDIYDLLGAIHKIETLEGPQVLLSASEDKERETPLSPFPHSNRICKVLDSLATLCVSQRKHEVIALATRYDATNRTIRFMIASDADVLPETEKPFQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGJ4</accession>
    <name>A0A1Q5TGJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGJ4"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="181"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="402" mass="45790" checksum="3ECBE01AE1C72529" modified="2017-04-12" version="1">MAPQLHQRPPFRAEHLGSLLRPQDLLEKKIASEKGQISEAELAAVEDKEIKDILATQLKLGYRGASDGEYRRHMFWGTFFPGLDGFEEVTEFETDIFRPYAPDIAAFLEAGHKPGETVLCTGKIKHVGSTYVDQFKYLAGLVPKDEVKNLKITLAAPNWYHLRYREGKAYPKDVYANDEDYFGDIAKAYQAELKILYDAGCRNVQFDDPNLAYFCSEKFLSGFKEDSLNVYTADDMFQKYIKQYNDCFIGLPEDMHVGVHLCRGNFVGSRHFSEGGYDRIAIKLFQELNVHTYYLEYDTERAGGFEPLKHLPRHKNVILGVVTSKFATMENKEEMKKRVIDAAKFIAEGNNISLEEALNQVGVSPQCGFASHREGNAIDWDGMINKLKLVREIADDIWPNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGM8</accession>
    <name>A0A1Q5TGM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000662">
        <property type="protein sequence ID" value="OKO99374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="13246" checksum="BDC850B9F63CC297" modified="2017-04-12" version="1">MSVKIVPEPPAEGTKASSFFMQTSMKERTYFDSGDYALSAADRVTDNGTIQTGKAHPHRDSISHPYAPIPAGSNVDKDAIEDLHRKSASPEESPLLQRTNIEHTEPSIKKRQDDRAPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH63</accession>
    <name>A0A1Q5TH63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_8418</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH63"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="16">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO99573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="200" mass="22815" checksum="7732758A807E4528" modified="2017-04-12" version="1">MTQDAPSDLRYVRYDSARENEYVAAMRQLISKDLSEPYSIYVYRYFLYQWGDLCFLAMDDKGEMVGVVVSKLEPHRGGPLRGYIAMLAVREEYRGRGIATKLVRMAIDAMIERNADEIVLETEITNTAAMKLYERLGFLRSKKLHRYYLNGNSAYRLVLYLREGVGSIRTSFDPYGLPPAPLPTLDQIFHPPAIAQGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THH6</accession>
    <name>A0A1Q5THH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 8"/>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THH6"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000005">
        <property type="entry name" value="Arabinan endo-1,5-alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012682683" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="10">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="321" mass="34094" checksum="F0465F125EB8E126" modified="2017-04-12" version="1">MVVQKLATPIALFTALVRGYANPGSCSGACNVHDPSLVQRTSDSLYFRFSTGNEISYASASSIKGPWTTIGSMLPSGSSIDLAGNTDLWAPDAHIVDDLYYVYYSVSTFGSQSSAIGLATSATMESGSWTDHGSTGIASSSSKAYNAIDGNLIDVDGTYYMNFGSFWHDIYQAPMNSAATKVASSSYNIAYNATGSHSEEGSYMYKYGSYYYLFFSSGTCCGYDTSRPAAGEEYKIMVCRSTSPTGGFVDASGIACTSSGGTVVLRSHGTVYGPGGQGVFTDPSLGPVLYYHYVDTTVGYADSQKLFGWNQIDFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THV4</accession>
    <name>A0A1Q5THV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THV4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THV4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="736" mass="81340" checksum="D0D8193691B8D7E9" modified="2017-04-12" version="1">MPEAPATSRNRRNLVISGHIHPCYGYRWFRPRGARDAKRYDPTCGLNSEKKIDLIEERLGGVEETLQRLGGIEQALRELLISSRHQGVGSTAKFSASSLSSPDTLARSQSSAPKQDHADSKAPGYTSNAAIEQHDSGSTFEGNSSLAAHSAYAKEFLESAVSHSTPEMFSSPKINEALSSLKQIVEMQSKQRDSGTQRGQLSSRLGARCDIRELEMPPLPVVLTVLKKAKENPPALFGGYIPFFSVDYFISRCQEVYFATEDYSDATFIIANFGLYGIFVEFGFCEKEPATRDEYQRYVQVCKDNLEAALANLNILMPVTMDSVVALAVGALHGIEISKPSVSWTLASTAIHMCQTLGYNRLSSMEHDPPELQHRKQDIFWSVYTIMNLMSLRLGRASVVQACDVDIPSPFECFPNMGVWSMVCALWARQAVIQNNIYTNLYSPAALNQPESERVMHARQLAIEMKRDILEPFDQILNADWNISEVDYIYLRSDGVSRLAILTLIYRAIPVEPGSSSTFIPECIETARATLELHQVCIGSLKEASENLRCSYMHWAIFLSPFVPFIVIFCHVVTTSDSKDLTRLEDFVASLLPLCRFSQSIDRLHNLCSVLSTVARLYVEAKSRKQAGEDQNMASVGQEFDAYLSALGLAPGNAIANNPWGALQPDGSAMTASMADPSLQASGFGNPAVPTQGQVQGQDISVVEMSQAAQLGSWFSGNQYMMGLLEEDMFQINNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIB5</accession>
    <name>A0A1Q5TIB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIB5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="37311" checksum="DF42DA5E5287BE81" modified="2017-04-12" version="1">MAPQIPEKQWAQVVQKKGGPPIYKEIPVPKPGPDEVLVNIKYSGVCHTDLHAMKGDWPLPLKMPLVGGHEGAGIVVAKGELAEGVEIGDHAGIKWLNGSCLSCEYCKTSDEPLCATPQLSGYTVDGTFQQYAIGKAAHVTVLPKDIPLDGIAPILCAGLTVYKGLKESNARPGQTVAIVGAGGGLGAMAQQFAKAMGLRVVAIDGGDEKRAVCEQLGSEVYIDFSKSKDLVAGVKAATPDGLGAHAVILLAVSEKPFQQAVEYSRPRGTIVAIGMPANAFLKAPVFETVVKMITIKGSYVGNRQDAAEAVDFYARGLIHAPFKTVPLEELPKVFELMEEGKIAGRYVLKMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMA4</accession>
    <name>A0A1Q5TMA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMA4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="16893" checksum="3202499BD7049327" modified="2017-04-12" version="1">MKHETRSTCQISSPSLDCWPFVLDSLPRTGGMENKYLNRRGLEERLSIPFSVSVYFHREDGSSVSNVVTKISCEATNRGARIDGSALSWAQAEEVAPIIRKWATEIEYALVNLDRKNSRATMLLEQERVIRQWEARNCCTSDGYDQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ68</accession>
    <name>A0A1Q5TQ68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="164"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP02369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="570" mass="62835" checksum="19DA2E9E727F7AF1" modified="2017-04-12" version="1">MKLQPWRNNDWVLRPRSYLSHSKLLQPADGSRKLSVSSTRPYRTLEALPDVDVDTFRQRYFAPEHPVVLPRSQFRNLPAVKNWFESTSSRSTVTNRPKTRLNLEYLQKHAADAFVPLELTELAVSSPPAKDNGKLSHQDGATDVVSFRQFHGPLTLFLEWMRTAETSPQSTRLYLAQCQLLDLPQVLRDDFPTPDIVAKAGKGDVYDTNVWIGHPPTYTPLHRDPNPNLFVQLAGQKVVRLLAPSDGQALFSSIRRQLGKSGGKDAAAMRGEEMMQGQERALLDERVWGGSASAGPEGSGYEAHLEAGDGLFIPKGWWHSIKGVGEGVTASQKQNYLVHAESELLRAASRTISTPPLTDHFIAQLNSPTTTLPHNPSMQLSRTAYRAALFHLSVNPLLARASIPSAWSLSASSFAQQPQSCGTSSRLYSILFSQCAPGNKTLESIRHSHTMSSSTPPTDATPAKQETGEAQSQENIQPEASKEQLYLPSTESSNSDGQSKQIRLDLGADGGVTLDHLGPMVVNVDGSLSRIGNWEQMAEIERKNTLRIIGKRNKQRLEKLRAAEAAGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRK2</accession>
    <name>A0A1Q5TRK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_6930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRK2"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000014">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="178"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="324"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="490"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="626"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="824"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="982"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP02858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124781" checksum="3FC847F209C242FB" modified="2017-04-12" version="1">MSAHAVKRRKLSPSPTNDASATQSKSSAGATTTEKPAHVPARKNDHSSKTNSAHRAKDERTAELAMASGFYKSGFFKLQVDELVSGLKINYDKRISKVQDTLHKVKNAIESLPELSPKSIADAEKELRTASGIVVPWPEPRPSKDVKYTVSYAKPTNINVVGSFGLRTGAKTTDSRPVDLAVTMPGSIFQEKDYVNYRYFHKRAYYIACLAAGIQETVNSLGLDVKFSFQDGDSLRPLIVLEPRSSKDEKTPSQPQIRILTAIDPSLFPVTRTLPMKNNIRQGPSADTTEAGEPTSYYNASLRSEAAVSLYHKYLHSASQKCESFRDACILGRTWLQQRGFNTSFQKGGFGGFEWSALISLLFEGGGPSGQPILLRSYSSYQIFKATMQFLAGRDLSTPLLLFTSDVPVPDGGPVLYDGRRGLNLLYKMTPWSYSVLRQEATTTLKMLNESREDNFDRVFIVKVDEPALRFDRLLTFPKSFNGDTLRSLHDQKSLYQVLSRALGDRVNLISLTSRSSNSWPVKSKALNKKASHDLSVGLMLNGENVGRTVDHGPAAEEKEEAASFRAFWGEKAELRRFKDGSIVESLVWSDQPDEDSIVHQILAHILQRHFKIADEDFFLHGDEYDDMLYDEGDRVISYSNSPFQSINDAFGELEQSLRNMEEVPLSIRHVAPASPLLRYAALRVQGADGDNEAADVVLQFESSSRWPDDFAAIQMTKAAFLVKIGDSLQAAGAASSCRVGLENESSKVLNSFYLDIFHSSGFTFRLRIHHDREQTLLERQLKNKSISPREREEVAFALFSYKKVFVQTPRLTQALRSLCTRLPLLSPTIRLVKYWFASHLFSAQISEELIELMTTRAFTQPYPWETPSSIMTGFLRTLHFLSRWDWQQEPFIVDLSGDLNPDVTETIKTRFTAWRNIDPAMNTVALFVASDLDTEGVTWTQYEMPSKVVAGRMTALATAALNLLRKEHDELDVADLFHTSLAPYDFVIHLRSKPLDDRSGPASKYKNLADANAPGRAGKLAIVKSFVHDVQACYNQSILLFHGDERSGVIAGLWNPQMLKPRTWNLKTAYSTAPALVSGSPEKQDSVMINQPAILNEIARLGEGLIETIEITGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRN9</accession>
    <name>A0A1Q5TRN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">(S)-2-haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRN9"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26861" checksum="46D586E8BDFC153E" modified="2017-04-12" version="1">MAQLSDFRVLSFDVYGTLIDWEGGILGAFQPTLDKNQAQFTRKHLLTLYHELEREQQTKTPEMPYHQLLTTIHPELAKRLGLEIPSQEESKQFGESIGNWPAFPDTVDALKRLSKHYKLVVLSNVDRESFAKSNAGSLEGFPFDLIITAQDVGSYKPDLRNFEYMLKTVKSTFDVEPSQVLQTAQSQFHDHHPAKKIGIKSAWIERPGATMGNLAENVFDWRFDTMGDMAGEVEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU86</accession>
    <name>A0A1Q5TU86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU86"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="598" mass="64680" checksum="2A07DF7E5BFE0240" modified="2017-04-12" version="1">MPQVEPPKKQANTAQGPSSEQRTNPRKLPGTNQVLQQTRPQKVDPGIRRAPIPNTTSKANVKMPSTHVPPAPQKGLREMQPQQNYTPPPKSTGLFRNLFSSSKTSGPGRAPASTAVPSGTRSGPYQPYKPPSNAYLPYHGPPRMGQGQFMHGGHSNGHFGPGQHQSWGHGNQLGYSHGFYDGIGQIPSHSTSIGPDRPTDPVLPTDPIKPTVPVKPTNLVKPPSPVVPAEPTGPVESTVPAEPISPVESTVPAEPISPVEPTVPGEPTNLAKPPSSVVPAEHVGPVDHTGLVKPTVLLESTNPIQPTCPVEPATSVNSTVPVGPTDLPKLKRPDENARDGSNHDGNRSQSHYQGHGTDGTHQVQNQGGGVGTIAAGLAGLAIGGVGGAILTHMSQGESSESSDEEHNDTHDNEDKENDDDGESDEDTDTDSGEDEDSDEDEESDEGENSDEGEDGDNDSNEDSDEDEESAEDSEGNTEEDDSDSDNDSEEDREDENDESDDEQEDENDDEEEDEEEDEEEDEGEDEGEDEEEDEEEDEEEDEEEDEEEDEEEDEEEDEEEDEEDNSDDDSDNEEEEEEEEVDYDGDDACSYDEDEGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXP0</accession>
    <name>A0A1Q5TXP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP04980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="8745" checksum="E3BA553CC74549E6" modified="2017-04-12" version="1">MTPKAFEISKATFTPRNTAFELSPLKPPWYAVVTVTRVSLVATDEACEFFKVVPGGQPPLTVGRLTKYVNIAPIQDGYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1A5</accession>
    <name>A0A1Q5U1A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1A5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="10796" checksum="E3FB9238A1F58C7B" modified="2017-04-12" version="1">MACPDCYWPSVLKSVENLHRQVCAMLGLNSDVGTSLPGLYDGNTIKFVVGIVERLCPPIECELAKYMDGKPASSKTGSGQWKAETMKTAFKSNGDIDPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4U6</accession>
    <name>A0A1Q5U4U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein argonaute-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4U6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4U6"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="718"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1083" mass="117686" checksum="4FF4F17A7638947A" modified="2017-04-12" version="1">MSDQPRPRGGGRGQNYRGGDRGDRGGGRGGGRGRGDFQNLPFRPSGGDRGGNRGYGDRGGRGGDRGGRGDYRGRGNDRGDYRGRGNDRGDYRGRGNDRGGYGGRGNDRGGYGGRGGRGGGGGPRIYNEGKPITPPDATVIKTEDAMAKALVASRQKNAKNPAQAYPDRPGYGTLGRPVTLYANYLPLTSVGKPIYRYHVAIAAEGGREPAGRKARQIVRLLLEEHYSANLKSIATDYRSTLLSVTKLTEGQLDVRYKDENDEEYSENPKVFKVTVQHTGDINPADLINYLTSTNAGDMLTSKPEIVQALNVILGHHPKTERSVASIGGNRHYSLQQGLMEKATLEGGLEVLRGFFVSVRAATARVLLNVQVKYLACYKSGPLAWTLREWMDANRNQSLYRLEAFVKRMRVCPTHIKRKSKNGKERPARVKTISGLATPRDGGTSANKPQVKNYGSGPHDVRFFLEAPGSQSTSPGNGEGKGKRGKKAAPKAGPARAGQYISVADFFKQEYGLAVDPDLPVVNVGTREKPVYLPADVCDVEAGQPVKTKLSPKQTQNMLRFAVMHRTPAQNAESIATKGVGLLGIGQPLNATLASFGVNLGNNLITVQGRVLPAPPIMYAKQKVLQARGGSWNMQSIQFSKPATLKNWTWLCIDSNRPGLTQESLNHALSGFTLTLREMGIAVDQPKPGIRLVYQWNVDNAPAIERAVRELQQKHQPQLILGILFAKEAQVYNIVKQVCDVRCGVQNVNVQAEKLSKPGGPGPQYWANVGLKVNLKLGGANQTLRNSDMGFFADGKTMLVGLDVTHPSPGSTSSAPSVVGIVASVDAQLAQWPADIRIQPARQEMVSDLDALLQSRIRIWANHNQGKFPENIVVYRDGVSEGQYDTVIEKELPLLKKACQTIYPASDTKKGLPRMAIVIVGKRHNTRFYPTNESETERSANPQPGTIVDRGISESRHWDFYLQAHSALQGTARPAHYFTVWDEIFYPLHPSVAPGAGAADKLQDLTHKMCYLFGRATKAVSVCPPAYYADLVCTRARCYMSGLFDPTPSGTPAGSVVGGESGERAPEASQATVHHSVKNSMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5G3</accession>
    <name>A0A1Q5U5G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5G3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5G3"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="215" mass="24271" checksum="DB3E63CB5FD2F196" modified="2017-04-12" version="1">MVLKLHGFPLSTCTNRVRTVLLEKGVEVEFIPVDLSKGEQKSEAYLSKLHPFGKVPVLEDTETGVQVFESRAIAQYIATKYRSQGTDLYPDETDLKAFALFQQAVSIEQAYFDPIVSQIAFEKIFKPRKGLGATDEARVQALLGQLNTVLEGYERVLSKQPYLAGDKLSLADLYHLPYGVLVEQFGAAELYAKYPAFQKWWTSLKARESWRKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U765</accession>
    <name>A0A1Q5U765_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Laccase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_5684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U765"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U765"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180232" evidence="8">
        <location>
            <begin position="20"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="78"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="203"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="435"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP08317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="612" mass="67441" checksum="E5BAD2647B2B173B" modified="2017-04-12" version="1">MVGLSFLSLLALAATGVSAASIPAPLGPGATPRKTNLTPGCKNGPKSRQCWGEHDINTNYYDTVFYTNHTVEYWLNLEEIDCAPDGYLRKCLTANGTMPGPAIVANWGDEIVVHVTNNIKTNGSSIHWHGVRQLNNNANDGTPGVTQCPIAPGTSMTYRFHADQYGTTWYHSHFSFQYSNGLYGPLIINGPATADYDEDLGAVFITDWDHETADLHWATVANFNVTFNGSDTGLINGMGTGNCTALNATKADPNCLSDGKKFELHFEQGKKYRLRLLNVAEEDWVQFSIDNHTLTVIAMDFVPIVPYQTKSIFIDMGQRYDVIVEANAPPADYWLRSGFQPLCIPNGAGANNISAIVRYDKSSTADPTSASVDGAIIAWDLCVDEQPSNLEPWVPVDLDLANVVAGIQTETIGPEWVDNNTYLRWWVNEGSFMWVNWSNPALGDVINGDLKAIPATDNIFQVGSNATAKSSLRRDEVEWVVLVIEDKTPFTGISHPIHLHGHDFLILSTGYEQWTGRTYGWQFKNPPRRDTATMPSNGYLAIAWPLDNPGVWALHCHITWHSSQGFGATVLESADKIPKPIGGDWAKELDPICKAWHEWEPTAPFKQTDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U795</accession>
    <name>A0A1Q5U795_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U795"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012457150" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8223" checksum="0F99177468534ED9" modified="2017-04-12" version="1">MKFVSLALAVMLPVASLAGAETSHGLEKRDVSAKTVVDGLAYRHCPNTACTLMGRLSAGTALHLYCYTRSGTTEVHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9U4</accession>
    <name>A0A1Q5U9U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9U4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9U4"/>
    <dbReference type="OrthoDB" id="3365211at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="74399" checksum="CD9D739279FCEA24" modified="2017-04-12" version="1">MDPIEPAEGSTAPGSIPDQSQPAEASSSRLAPATSRPRAPSNRTRRPSIRLSRLPSVSSLDTVNIQPQQELSDNQPGPSLTRQVSVKSPVQEEDESWQGNRRRSNSEPRPGRWSSPNHNPLARVATPMGCLTEESSHQSPMPVSPDELFTVKTAEEQLQPPPPALARPASRNVLRRTSQAALNRFSRNRASTVSGAQPALEANKEQPVNEYGSHVVDVLDVIDPEVSALSTLTNVQNSLFIPNLGGFINRMPTYQISRAPPSDEEQGTSTDEAESLEERQKKDRPRMDQLRPFSSMSSVLQGPRYAVLPDNHELEGWTKEDFAELNDHVRHMLHSRRSKFKRSMRGFGQYVRRPLGFLVTLYATLITLFGLAWVLFLIGWINVGGKQLYVINVIDNVLVALFAIMGDGLAPFRAVDTYHMIYIAHYTMLTWKIREERKLPNLKDKNDLPAQTEKDADVDFVEPPKEEEHEYSVLDERQQQRLMHHQAKFAKSHTFYKPHETVTHHAFPLRILIAIVVLLDCHSLLQMALGACTWSMETPGERPFALTTVILCCSITCNITGGVLIMIGDRRTRKKDIVERLFRQELTEEAMKKIEKRKERQSMQLEREERKSMQVDREGRKSTQLDRTERTSMHIDRQESEPESPQHERPDPFAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA75</accession>
    <name>A0A1Q5UA75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000528">
        <property type="protein sequence ID" value="OKP09366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="12689" checksum="4114A1A14DBBD2B8" modified="2017-04-12" version="1">MALGNLPEYAATEEIATEIPPNRLPFHIVCVVLFALVPTMHALAEPVTESSSLATAFGRFVLSNTLGAAVYLLEPFERIIATPNSNPSLHIMHLILVFSLVSYSRVVFDEMASRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAA7</accession>
    <name>A0A1Q5UAA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAA7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7709" checksum="5C8FA4B2C9B11C0B" modified="2017-04-12" version="1">MPGATIRLMEEPRWAIRGHVWGGALDDRPLECHRQAPGGPPRPCESRLATHELGSCDLRVAVEQLDPGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB86</accession>
    <name>A0A1Q5UB86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000464">
        <property type="protein sequence ID" value="OKP09742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB86"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB86"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="3">
        <location>
            <begin position="277"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="518"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="707" mass="80069" checksum="E8BF4C1031772634" modified="2017-04-12" version="1">MAPSQNCPILPSEHNMELKKPSPCHDGLTPPDSPTKGTVTSQAIVKDLKYLFGVFLEKVLDLTNREPPNTPASEDLSPPGPDMVQQVLECASAELSMATEPTQSNSVSEEQERLPGSGGFDPKHSICTTPDDFKSFEKWASTSQFKTVVETWDKEACKYKIAESVETNSGLDDYAEYAFIVRERVDRNSKEVTSYIDVKSEGLRDTLRTSLHDIKAISLTEDKPSIEQKVLFHFLPELDRCAENIDNSSDHDSAHAKHLRLLIEHLKHAYASISQRLESMLEHGHITYDLLWALFKPGGHVYTTCLGTKEPRCVRFDAGEEMTQRDETWWNLECRFMDYDGVKFGEAGIFLRVAKFRGSKPIESLEAFPLRYHPRHEQVRKDLVERGQKFRDLAGSHTRQCKGSAFFMNKGKAIKVNVSSRVAVDAAFFHEMQPNYARPSLRDLGVKDKDGIAVIDLGAMLMEDREREKEKMRGDGVDAQKLSETDLLVACPTVCCFSFQEKMFRELVVDHGDSHALEAQLEVIFKIAKHFNAILLLDEADAFMASRTALHDNHNRLVTIFLRKLEYYQGVLFLTSNRGIQFDDAILSRIHLIIEYEDLSKDFRRGLWSTFLARARTMQGPALVEEHDLRRLESLALNGREVGSRALICTSHLLTARKIKNIAAIAHALAEADANQVSYKYLELAAESSKKFSRVFDRERPVDGMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC37</accession>
    <name>A0A1Q5UC37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC37"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC37"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="266" mass="30004" checksum="CC3E795BDFA5553C" modified="2017-04-12" version="1">MRFFENHLAIDQTDRTPIQVLGAGLPRCATSSLQAALESQYIGLTPCMHFAHIAPNAERGDIVLAALREKDSTRRHKLLYKLFNGFQAATDFPASMFMDDLMDMYPDAKVVLNKRPGGGRQWVQSIKLLTFAASPVYRALCFLWKTDRNVAAMWREIMEVCQRKLNLTADELLTVKHYDAHNAWIHAEAAKRGRGVLEFEPQDGWEPLCVLLGKQAPRHEPFPHRNDASEVRIVVMILYARGAISWLALGAVVFGTVGWLVNGQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCD5</accession>
    <name>A0A1Q5UCD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 43 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCD5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF39">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012772971" description="Glycoside hydrolase family 43 protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28862" checksum="85D4A98028962E8C" modified="2017-04-12" version="1">MRVLYAILATLLAAPANSKYIVPGGRWHDTNGTLINAHGAGITFDQKTGRFWWFGEYKTQAQPEGPIDSHPYISPDNIIQRPKVAYSPETDDYHMWWHADNSTYGLLLQGHAVSSTIGGPYTFVDATAPLGNWSQDFGMFTDYKDGRSYALYSNGDSVNGRDVYISSMNDNLTALEKAVYRFPKFDLEAPSIMQTEKSYWALMSHKTGYRPNITFSRSKTGEWTPIKGTTYTAQNAKTSGDAYKQEAVSKATYRAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCK9</accession>
    <name>A0A1Q5UCK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan endo-1,3-beta-glucosidase BGN13.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCK9"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000043">
        <property type="entry name" value="Exo-beta-1,3-glucanase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012592456" evidence="2">
        <location>
            <begin position="20"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="536"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="897" mass="94571" checksum="DCF3A58E90529F73" modified="2017-04-12" version="1">MRCQFSLAAVAALTGAVSGAVVPVAEVRAGAGGVVEAHRISVPPWFLSLAAELDAIAPTETSSFLAPSSDINPDSSSPLPTPIESSPPVQSSPPVESAAPVQSLPPVQSPPPAPASSSEPATSSSSTEIAHPSSAGPTTPASPSAAPTVKTCPGPAQQSTDVYWLHAQDHNGQGAGYAPFTNDPKRYPVFRNAMDYSVVNDGSGDQTPRLQKAIDDDGNGGSRKGRGVTRNPAEVFLPGGTYQLGSTLTLTVGTIIVGDPNNPPIIKAGPNFQGEFLIMGYDKMNGNPETSFMMLVKNVILDTTAVSPGQSITALQWGVAQGAGLTNIQVHMPTGPSRHTGINIVAGSTIAVTDVTIIGGATGIINSNQQVNFKNVHFIGCGTAFEASGGWTVLLQGAVFESCGTGVNMTTNALGSLVILDSISTNSGPLIRFYDSSHDAGHQNSQFLIQNLEYNSKEPIAVDTNGHTRLEATAHVDTWVWGTMVPGAYAPGGAWNTHRSPQLLVDGRYFTKAQPTYAGFSGQDIVNVKTVPGHVVKGDGVTDDTVALNAILAQNAANCKITYIPFGVYRVSDTLLIPVGSRIVGEVWSVISGYGDSFRNPNNPRAVIRVGNPGDVGTIEIQDMRFSVAEVLPGAKVVEINAAGQQPGDVGLWNTMVTVGGTAETSISTTCTSQDPKDCMAAYMVMHLTETSSAYIENFWGWTADHNLDSKSLFTIISTGRGILVESTKGTWLTGTGSEHHWLYNYNFHKASNVFAGLLQSESPYIQGSGEFEKAPAPWTVDPEIGDPDFSWCGPNDDKCRTALATNVDGGSNIALYNSAAWAFFDGSWNGLYNEPCQGKCQANMMRVTGAPQNLIWYSISTRMTEVIVLDGKTNPREDNHAGGWEGIIQAYGEFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCT9</accession>
    <name>A0A1Q5UCT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_4264</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000361">
        <property type="protein sequence ID" value="OKP10308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCT9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCT9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF1">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE C186.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="165"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="352"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP10308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="549" mass="60466" checksum="21C3EA9A68225511" modified="2017-04-12" version="1">MVGCCNELNAGYAADGYSRSSPARAAVVFVTFMVGGLSLLNAIAGAYSERLRVIVVSGAPPTDTFGQDCLIHHTTGLKERDQAIRMFEHVTTASVRLDLKANPASVLDQALLRCLENSLPVYIELPANLAEYSCDVPRPLILSRPRGSLPSLVQDALDLFTRYWREAQSPVILVGPLARHGLTRDTLLSFIEKLGCPVFCQPDAKSLVPEEHPQFQGTFWGSISDPACIDVVMNSDLWVGIGTRSSDYNLVKRPTPPMLDLSPDHLRAPKGNLISPATMADLSERIVLSNLTGYCMESHNSASHEVTPSNGTSMESSISQPLTRAGILKAIQSLLQPNDTLIAETGDSWFNAQMIKLPPRVDYQMQLLYGSIGWSLPAAMGSQLARPEGRSVLMIGDGSFQMTAQELSTMIRLKMNSVIFIFNNMGYRIEVRVSRPALDQQLIIRIYQSAIHDGPYNYVSNWNYALFAETLCNISHSPGNGNNYLTDVERRDQNNPALFAMRIRTHDDLLLAVDRVLSESNKLAVLECCIHPWDISEALARFGQALGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCY6</accession>
    <name>A0A1Q5UCY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCY6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="19752" checksum="E2B145B979706A2E" modified="2017-04-12" version="1">MSQTSLSSPIAIADHYGSQLCDPHPTVSHQRSDKDRDRVRINSQCSSVDLPNSEDKDENAFSRYLPYSLLQHIRTASSNAIAAQGVQVASIDTKWRHHEDRPPVGQGYIGSVQHYYRTEEVHPLVRDSGPGLVMQGNPVTLTLRRSTRTSMLPTKGESAMRCIDKHPTILRPPTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEK3</accession>
    <name>A0A1Q5UEK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEK3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEK3"/>
    <dbReference type="OrthoDB" id="4461621at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="751" mass="87061" checksum="F5597F979632DA1E" modified="2017-04-12" version="1">MPAKGKRAQRSYLRQREPFLETVDEKTSLLVLLADFQGPIKDHVIDSVQDAAKVAPPEDIEEDEAQHRKRQTRLNVKPWSPSNFLLRSLAYQGPHRDSQANLYALAVLAHQYGHSELIVADELTKCKLAPAFDPELESRSPSESDVEINERSKPDCEVILISVYEKDVESKALSVWARRICIRDPDYIRRNVRWSKQTSIALMFSKSHDIRNAQTVAIPGAKRPRFNPRYSTPEFHYHDRGFEDTIWDQIGLELHDPDCPILSPDVVDGLGRKRQRDALRNTLEKNLPNLPKELIYDIADLVGDAPPINLPNWEFFPSKSHLVIFISFSMKEAEQELTKDMIDKKFQQHFGKKLAFSSRQNPKNESRCPEYSESDSSYDADGDEDEEDHNEWSRPRKAPEMTFELIPWEKHGATSRRDFMKLWLEYYPSTVIFQEGGRPPLHILAEPIKDIQAPHFVEILADNKSVAVASRTTLDKIISVTERVQNSSTFRFRDLHIPSSHSENLIDADQPFCRARISWQNPVLQSQTWIPAFYLTSKLTKEQDHDIRMEIKRPDGDYDAYMEVANKDCGFVPWKAGQSDGTIRDIWEIAQMVHKESLWRDNDFFICIDQQSAIDKKVILVVPDRRKVSHRWPRVKNMHLPNLTGFTFARIPARESHTQCVEIHRFHRVHYPFLRKRFLRPELLRMDRLEADRRYAYVDGEGKPLELAEDVDSEASPTDPSDVDDEDNESVDSLDALAEEMMYDTMYGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF13</accession>
    <name>A0A1Q5UF13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">COP9 signalosome complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="136" mass="15291" checksum="A273C29B09342B32" modified="2017-04-12" version="1">MEVIEGLMTQSAQLREAAYLSDQSYDRQIRENVASLRHVVSTKSLGAFASNDSLLDHFDPVADSLVYLFLLRAQIQAFQEQSREKVPAALLPPGNLWSRVVSYLRTFDPVPVRYAGQEWRQLIELVAQAAQVVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF63</accession>
    <name>A0A1Q5UF63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF63"/>
    <dbReference type="OrthoDB" id="5073671at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="274" mass="30104" checksum="5482B4C702360A19" modified="2017-04-12" version="1">MDPSPPPYTEHIQHDQSLEEQIPQYVAPAYNQSSSDSKSLQHAMAKFPPAMNGYFQWKMTSTFHLGLTAEQKLFAVSVHASVFGNKPSLILYDGPTKEDPVLATLKSDKWGRARPVDLTLPPRPHGHHTHAIDLQIVPASTSRVSPTFAFETQGTGKGAGRERFEWRKTHGDEIKELATGHSYGWKLVWLSGPIHSAGGSRKEREMGVASDGTEIVALLAHNASWSMTKGFRFAFLATGLNGTFGETWEIMTVTSALHLWYLDFQGAMAAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFA4</accession>
    <name>A0A1Q5UFA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000294">
        <property type="protein sequence ID" value="OKP11154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFA4"/>
    <dbReference type="OrthoDB" id="4232626at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11855" checksum="BBD0EE91A6644E4C" modified="2017-04-12" version="1">MLAEREAHVVAEEEVTGQPSTWERVYELMRCNVRSCPHKSDWCWEDPKDKKHYKLRTPHLERLIDIVDEGGILDGHDDIPGDIRRDLTKARQEESIELWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG06</accession>
    <name>A0A1Q5UG06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capreomycidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG06"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="50"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="410" mass="45437" checksum="E7FFA16FC4FC18B9" modified="2017-04-12" version="1">MVKLEAFAVEQWMDKYETTAKYNTAETCCASISIDDLRELSEDKDTNPLTALQSTKLTYGAIRGSDKLRETLSNLYSVKIPNLVPKDNVLITAGAIQANFLLLYTLVGPGDHVICHYPTYQQLYSVPASLGAEVSLWNSKEANDWQVDIEELKSLIRPNTKLIIINNPQNPTGAIIPRDTLQSLVDLARESSITLFADEVYRPLFHNISPLDSQFPPSLLSFGYEHSVVTGSVSKAYSLAGLRVGWIASLSNSIIEACASSRDYTTISVGQIDDAIASFALAPDCIHNILKRNIALGRTNLAILEKFIESHRWACDWIKPRAGTTAFVRFNKMGKPVNDVAFCEMLQDRKGVMFVPGSLCFGGGEDFKGYVRIGYACETEVLEKGLEAVREFMEDDYDEVPALKKVKAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGD3</accession>
    <name>A0A1Q5UGD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexaprenyl pyrophosphate synthase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGD3"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48938" checksum="3A6B7182C7970CB0" modified="2017-04-12" version="1">MRARTLSAAGLTITRTSSTSVCSQCLRDDLRLTQALIQSRKYHPSRRQDVSPFGAAATAAQAIFKGLPKAPPGVSVDPLRIVGKELKFLSSNIRQLLGSGHPALDRVAKYYTRSEGKHMRPLLVLLMSQATALDPRKDLTRTPNTNPVDISLSPLAILEDTNPDTDPIVPKSAEAQTSFDGDENILPNQRRLAEITELIHTASLLHDDVIDNADSRRGSPSANIEFGNKMAVLAGDFLLGRASVALARLLDPQVIELMATVINNLVQGEFMQLKNTAKDEAKPEYTNNTVEYYLQKTYLKTASLISKSCRSAAVLGCSAPEVVEAAYAYGRNLGLAFQLVDDMLDYTLTEAELGKPAGADLELGLATAPLLFAWKSNPELGPMVGRKFCREGDVQRARELVYYSNGVEQTRALAQDYADKAVAAISDFPDSDAKAGLIEMAEKTMKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGH7</accession>
    <name>A0A1Q5UGH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGH7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGH7"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="314" mass="34276" checksum="332F9A4C2A342D27" modified="2017-04-12" version="1">MASTKSVALVIGASRGIGRQIAIDLASDGYAVMLAAKSASPTDTTSPFPPDPNSKASTITTVAHEIHLAGHTAATVVVDVRNPDQIQNAVDETLRVFGRLDVLVYNSGAIWWSSVENTPLKRFKLMQQVNPEGLYASVQAVLPVFGKEGKWKGRIVVVCPPIYSRFFRGKTGYAMGKVGMSVLVKGLAMDFIRQERSEMAITGIWPASSIESAATEFNKSEDKSYKRDLRKPKIFSDAILAMLRAPATTVNGLLDTDEDFLREKCGVTDFSQYAVIPGSTPRRIMPAKFPVLEVAEQDDEGQRMDSTKIRASKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGJ8</accession>
    <name>A0A1Q5UGJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000275">
        <property type="protein sequence ID" value="OKP11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGJ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="46"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="483" mass="53825" checksum="FDD54F5BCDC21947" modified="2017-04-12" version="1">MPSFVEQVNSKKHLCNQGFFASTMAVCSLVAGRVRDGALYSNRWDREELIDPPSETFFVAARDSIPRDLVAAKGIHYMRACAILAIASIQNGQIKNMQKYFGLYHTLTSLDGLYDEKFWPQDLNPIQTEERRRLFWSIYTLDIYSSVVWGGVIRHREAHSLVRYPSELDDEFITNRGYGVPSISPGLNSPLTGNVTVVSRQPVPWLRGWNFTTDLYRILEHIVDGNRRRFSSANGMTQVWPLFNRLSISEPAVMEQVLTMYSALPSQFRETPPITGDMSKNLFGFQSANIQATLQLLRMVLLSTEEIGVERKCDVAGELLSGFSSVPIEYLKAISSPLLHHLGGIGYILGSVMEGNLSEVSYTRARTLLLEMAGLLQRLEMGLHRASGAGERLRSQVDRIDGYMRTSLPVDLTSPSDATQIMNADPELAVPSAYGQGTPAVGASPGAGLDQMSQFQLPPELLSDWPWPLDSRSAEVFLPLPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGU2</accession>
    <name>A0A1Q5UGU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein prenyltransferase alpha subunit repeat-containing protein 1-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGU2"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40722" checksum="9811C81589499584" modified="2017-04-12" version="1">MTAPADAFQQLAGVFASRGDKILDIEIIPSSLGSPFLQDGCAIGITKKTLVQAYTVARQLFSKKLMPMTEDDLLVSLLETDSSRGIASDQVTTEIMLLFDCEHLTACNWRKRRLLAALVRRKDVPGRDSTLIRILKTELTLLQSYQCSPLHRHTKSPTLWSHRIWVLEQLLKIEEQSPEALLDLERHELAVVLRAGELHPKNYYAFTYMRQLHALLTRSPVEKRDSPNWSAVLAATLVNPVLDWCLANPRDISGWVFGIYLLSHVPDRQLQVDAVGRVLRFARDVGWEGESLWTFIDQTVRQFDLESVVDEAFLLDQKRREPVSTTVVKSSLTKWPWRGRLDRARAYWAVYGSSHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH19</accession>
    <name>A0A1Q5UH19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="9">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2825</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH19"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH19"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000105">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="11">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="72"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="29469" checksum="3EE66B82809487D2" modified="2017-04-12" version="1">MPSLQESKLAFIGGGNMASAIIGGLVSKGVSKQNIYVSEPWDINRDKLAAVGVRTTTVNSEAGADADIVIIAVKPQVTKSVCEELSASWTQRQTLPVVVSIAAGITLNSLQEWSRTSDGRSAHVVRVMPNTPALVGEGASGAFPSADVTAAEKDLVNSLLSSVSKATEWVDKEELLDVVTGLSGSGPAYFFAMVEHLVASATSLGLSQEQATRLATQTCLGAGKMLVESSDEPGQLRKNVTSPNGTTYAALQTFEALGFKETVDKAVKAATSRAAELGNTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI85</accession>
    <name>A0A1Q5UI85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI85"/>
    <dbReference type="OrthoDB" id="5352317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044415" description="Small secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="14938" checksum="19576365F5BE1BB7" modified="2017-04-12" version="1">MQLSQLLLATILAAPAALAAPVASSVSMMAASPEWTIQSMKRVCATNDSSCTWTFGIYPGSGDATACKLVVTANTASQANGGPSSCGDYTVTSGWSGQFGPGNGFTTLSVVNNKSRQIIWPAYTDKQLAGGNVVTPDQSYAPAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIK4</accession>
    <name>A0A1Q5UIK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIK4"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270871" description="Alginate lyase domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="5">
        <location>
            <begin position="72"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="52155" checksum="4C2B97A3FE373FC8" modified="2017-04-12" version="1">MRLPFICSVLALSLHASAWTHPGLLVTDSDIARVQAKLAAQKEPWVSSWAYFESLSFSSSSYSPNAVSDIDRSTNGDVLWHDAAAAFNLALRWRVTREEEYAKAASAILTAWGNTLTTFSGGDDRYLSAGLQGYELANAAELLRDYAPFVQNGWDAFVDMAVNVILPLNFRFLNHEEGSEHNVRHFFANWELAQVASVQAISVMTENQTAWDFAIDYFKNGDGNGAIGNAISNLVDEPGTGTLLGQGQESGRDQGHSALDQQLLAAIGQQAWNQGEDLFALNDSLILRGAEYFARYNLGHDVPFEPYTNGIVSYTDISSASRGATRPTWELMYAHYVQIKELEAPWTKAYLNNTLEYFGGYEKGIGYGEGSGHYDGVGWGTLLYRLEESDLEVLKQGMTATSQVLASSSPVSSTSAVIPSPSVTAISRTTPSTSPTVNSSTDSIVSTTTGTIAEAKTTKSPLEHSHGHGPHTMHSGGHCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ22</accession>
    <name>A0A1Q5UJ22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1836</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ22"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ22"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000018">
        <property type="entry name" value="Nuclear RNA export factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="398"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="634"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="690" mass="74879" checksum="E779D38ABBEEA2B3" modified="2017-04-12" version="1">MKTMKSRRSGGDRGGIRKRGPIRTDRDGDMDMDAPGGRGGKRGGRGGPGRPTGSGSGSGAGVGRPARSGGDRPQARDKTLEAIQKAISNTRDSQVSIRQGKNAAPSNLELFSVLGWKESKVSSHRDGGVENLIAFLERRMNAHSKSGPRARITKSRVEGDSLVVFVRPDLSDRMLRLHDSLFAGVHLVVEPYDPSSSAVLDRELGTATGTSPSTADTKSKMTLILSKRYYPDTKLLDLSKLSADPDLVAMGIFNQTSTESKFFPALMKVWEMGFTNAAQRREAVESVSLAHNSLTNVTAVTTLSQTFPDIKNLDLSHNNLKDYRSINAWRWKFRNLEFLDLTENPFSAEPNFKETMMKWYPKLQTLNNVIVRTAEEIAAQKKTPIPVQAPHFQDDGQIAENFIRAFFTRYDNSRDELVKSVYDSQSEFTLNVNTSAPKAQQTESAGWDPYIKKSRNLLKINHLPARMSRAYTGADKILELWKSLPQTRHPDMSAHPEEYLVECHPVPGLPDPTGQSPTGVGGLMIMVHGKFEESVGGKVETRSFDRTFIIGPGGGMGGIRVINDILCLRAYGGHEAWSPENQAIPYATAPVAPVAGAAPVAVPAPAAAVPAPVAQPGIPQGYGAPAPGKTDAQVQQELLVAQMSAKSGMTLQFSEMALSGNGWNLDAAWKNFEELKASGSLPATAFLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ38</accession>
    <name>A0A1Q5UJ38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCR4-NOT transcriptional complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000203">
        <property type="entry name" value="PH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="98"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132974" checksum="70A09D252B19A724" modified="2017-04-12" version="1">MSTWGGSKNNDSGKESKRSSRNITPAETPPRWQTPSPDTPSPPSELSPVGGSNPRGEGISSRPASMIFSRNPPLMTHEHDTPPELSPIFSFLNIHTNKVYHEGYFLKLNDQDSHGRPCGDRQWVECYAQLVGTVLSLWEAAALDAAGGEEVPATYINLADASIKMIETLPIRNGAVQPLKNVLSLSSAGKNRYLLHFSSFHSMTQWTAAIRLAMYEHTSLYEAYTGSLIAAKGKTLNGIQSILAPTKFKHEDWARVRFGAGTPWRRCWYVINPPDEKELQKARKLMKRSAYDRLTMPVTGSIKFYETKKTKKVQPIATVTHVYSAYAIYPQSKALIDQSTLVKLEGRITLHSGPQTSAEGFVFVMPELHAAVSGFEMMLRFLFPTFDTFNLYGRPTRLVADVNHIKSIMFAFPKQRRYGYLEVLDITNLLQIPGSQEWSEAEWRKQLKDATQKRMSTGRSRTNSVNSSRPRYRASISSRPGESSLNGSRQHLPAPDSKPEFNHSAEAIIHEVPRNDPVGYHSRGMSDTTGLQTGPRHGYGSLIESSPDSSAQDLVQRDRAQALAGPIAERISSESDRNSGLLERPFELEEQLPPRTPPSPVTKPPTFAHGPREMPTNRPKTSNEQRLANNRMSHTTLMQFHQVGKTGMEMDGAALAYQDPHHYYQQQHPDTTMDQRLQQIRDQAHYHVYAPQPVAARGSPLKNQSSDEGLAFPSRQVPTSEQRPVTPSTGTPSPQRNLQIDTSKAVKRKPLPQRQLFGGPPLSPDGGEPSFDDLRHTLDEDALNRIAPHLPSPMSPTPNEEESVYDDASTVSPDYASTHESVYSKKSAKRMGVKKTVGEPAKQDLVIGDARYATDKPAEPNPDIPTVDFGPTLTYMPTTGRPTTGDTLKKASHQRNESDFKLYVPTSPMERGHVRSPSQEERRRSVLWQPGMASGRPTTPGGGLTPEQFVQQRAAPSPPVHMHQRVPSNNSPPPARPVSGDWTRPHSRMTSYPDANYRPSSRGANTMITGYNDVGNHLSAREQEHVARMTGSSFFDMSTNTNKPQPQVNPMGLVSTIDARERERREMKEGMSNQMVQHAIAQRQQHQQYQQQQQQQQQHHQMMQHPQQYASQYAPSVYPPPTRDGMYNLPGASQTWDALHQMNRSDEPRRRSWYGQLAQASSQVPPSYQQSQHFTQQGGYPANYNTTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJI6</accession>
    <name>A0A1Q5UJI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS-type drug efflux transporter P55</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJI6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJI6"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="52805" checksum="E05515A0F605B9CB" modified="2017-04-12" version="1">MASTAGYQPLHDDDTPLRPTIIAGIISTWIATFLAAADSTITSTLSATIANEFDSLSIISWLGSGYLIGLTATQPLSGKLSDIFGRRASFCCACCMFTIGNLVCGLAGSKMVLITARVVTGIGGGGSISIATFIASDNIPLKRRGIWQGTGAVVYTAGMGLGAVIGGAVNDAVGWRWAFLGIAPVSLLAGIGVAMFVPGYTDDTQGWRELLSRVDFAGAATLVASLILLLVGLNHDGPELVTGLFAITVPLGLLLLAGFVLIEWRWAREPIIPLSLFRQRTVVAACLTAWFMSMAFYALTFYVPLYMKMLGHSTSQIGLRLLPDSIGAGLGSFLVGLVIRVTGRYGVFRYTVTLLLVLASMGYALISVNTPWILPEVYLLCKGFGMGGALTMLILALLHSVPHERHATATSALYAFRSTGATVGLSAASTMFYHRMNQNMLNNGSSCQEGDPCYLDALHGAFQLALAFATAGLVSALFVSTYDKRGKEDEGQEMDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKE0</accession>
    <name>A0A1Q5UKE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKE0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="264" mass="27843" checksum="AD81C6943C984360" modified="2017-04-12" version="1">MGGCALLEASNARQMVQMQASPVFARTPPPPPPAPGASLSGAVAEAPMEQNLRMVSSPVSSFGAPSPPPSSQPAFGAFGQAQPLAQSAFEAPPGDLFGSSTQPSTGGSLFGRASSGSNPFANITVPTPLSMPSQKKASLTARQEPDNAKPAQLTKPSKVHALVGLQTFEGNWEWAQSLFDVLGYNMADIQVRVLHLLQVESLGTDAANIVATVLAGAFLLNKNADSRSVWELVYDKVEFWVSKILDQVCFQVIEAHKNEIMALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL55</accession>
    <name>A0A1Q5UL55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL55"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL55"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="284" mass="30125" checksum="43A7282ED1986A3B" modified="2017-04-12" version="1">MNPPLPSLTSTWHNGSYSAISPLRAELSTAGKTIIITGAGSGIGRATAQSFDKAGASKIVLIGRNEATLRETQATLKCDSSVHAADVTDEKALAAVAASTGTWDVMILAAGYISPRASIRDSSVDDWWQNFETNVKGTMIASKEFLPTANPRRAAVVAFTAVVVFPAAQLVNLSGYITSKLAVIKLMEFLAAENPNVFAAALHPGMIETKIFRGSGADPSQLPMDSVELPADFSLWLTSSEAAFLNGRSVWANWDVEELKAKADEIQSGLLLTSGVYGWPFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULD6</accession>
    <name>A0A1Q5ULD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULD6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULD6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="791" mass="84557" checksum="AF92F4F3641DD076" modified="2017-04-12" version="1">MNQMNVGMNPGVGGPVGGVPMMNNGSTAPRNDGGMNMNNPEMMITSLNTYIYDYFLKRGYHDCARALIQDESIKINTDNGTKTSPGSRRDGDVNGVDGDPMMTDGKDGEKIKIPDDLPRPSLPNESLQSSFLLDWFSLFWDFFWAQRKRGNSNDVRQYLQHTQNLMRIREQQHNQLMRQQPMMPGQVPLGVRRGGNGMVPPNLQKAALNNGLSQQQLAAQFQKNQQMQMMQQMQREQSEMDMNGNRPQSPASADNAPSPSKRPRLEGGAVNGQQLAPNGRGQGQMQGQQNPQQLMMPNGMQRAMNPAQFQQFQQGQAAQQKSMQVYAQNLALHHSRSALNSQGLPNGGMMNPGVMPNQADLVPMPDGQGGMYPMGPEYYSSNGQLQQVRPGMQTPGGQHGNHALQDYQMQLMLLEQQNKRRLMMARQEQDSMSRADGQPQMPGQGLPPGTSPQGSRAGASPNPSDQMKRGTPKMPQTGLPGSPSAGDMGQNRGSPASMGMNGGQMPPDMAAAGFFPGPGGPMRPPSSNPAFTGAQMGQPIPANAGRMPSGQWQPGQPMPQHSPATQPQAGTPQDRSTMPPPQAPPAGANAGRPQPPSPQTTGNAPPTPQQSTKAAPKGKKEGAKENTRKRPNKKNAAAAAAAATPSTEANEPTPTPSTPVTPHPPPNSFTKGGPNAAANAPQQTAAPAPPPMVQPTPDPSQQTFNDLAIPDVSHDLYSDLSLYHSAQTADAQPQQASAFSLDFSTLDNPDILESFDFDTFLNTDGDGTGFGFDPNMGYSADGVETGAGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULF1</accession>
    <name>A0A1Q5ULF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULF1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULF1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000377">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="362"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="54408" checksum="30BEB5846B85B688" modified="2017-04-12" version="1">MSALLETSLGDIVIDLLVDESPKACENFLKLCKIKYYNFAPVHSVQKDFSFQTGDPLGPDAPDSDGGSSIWGVLGGPAKRTFPIDLPPKMKHLERGTVSMATVPAANDPDQRVAGSQFLITLGENLDYLDGKAAIFGKVVEGFDVLEKINESFIDDRGRPLKDIRIRHTVVLDDPFDDPAGLVEPPESPVPTKAQLATVRIADDEDLDEEMDEAAMEKLRREREARAQALTLEMVGDLPFADVKPPENVLFVCKLNPVTQDEDLQLIFSRFGTILSCEVIRDKRTGDSLQYAFIEFENQKDCEQAYFKMQGVLIDDHRIHVDFSQSVSKLSESWRNATVSKRQQRGGFGGVADLELKRQYRVSDDSRAEDDDRAYNMVFDRSRKAQPTAPATSAPRRDGRSDRSPPRDSYRDRRSSRSPRGRDSHKDRHRQREASRSPGRRDFERRDRDRGDRGRYRDDRGDRGRDRGRRDDRYERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULR9</accession>
    <name>A0A1Q5ULR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin-like domain-containing family A member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULR9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULR9"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="22930" checksum="326B0D975D0F2DB8" modified="2017-04-12" version="1">MPRTNEVHAPGTWFSKIERSFEEVPIDTANGNAISTVEFLEAAGALVTLFDVIGGVGLAAVKSDLSGNIAKVQERYTKAPAESQTLQDLVRNELKSGQHKATEGLLWLVRGLQFTAASLRLSINNPSEELNASFLGAYKAQGGLSTHHGYLIRKGTEVAIKSGVPYRKDFYAKLGDNQADVTAALEKEVKALENVVDILMKFQATPEAQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULU0</accession>
    <name>A0A1Q5ULU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULU0"/>
    <dbReference type="OrthoDB" id="202289at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="398" mass="44240" checksum="B796D914C5B3AECE" modified="2017-04-12" version="1">MEQHTLRRRGLGLRGVDEQRVSPGYVLYSPLTSNTAHLVSTSGKEVHRWTLPHRAGRHSRILPNGSLAYNGVHPDAPRLFPMWAKYRGGVMIQVDPSGMILRQYSDPYAHHDQNHLDDGTLLYTTLEPLTAEEAARVRGGIPGSEAPGGIIYGDCIRLVDPWSVSNTSSSADFDGGNGTGGAKLLWSWRAIDHLDLEAFAAHPHYAREHWPLINSVSFDSEGNIIASTRNASGVFIISRKTGEVLWHLTAPTVCQQHCAHQINSAGDILILDNGVFRPEISVPFSRAIIVSRHKQIKWEYKDTTTGGLGFFTPFMGSAQKLENGNVLICEAATGRIIEVTEGGEVVWEFAVPQLQDYKAVMSKDELEEMERIGFSNQSNAIFRAYKYRPEQVPWVKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM18</accession>
    <name>A0A1Q5UM18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_695</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM18"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM18"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067155" description="Amidophosphoribosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="13">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="571" mass="62596" checksum="DFB80DFEFF9051E3" modified="2017-04-12" version="1">MCGIIALILANPSGAAAVDLHEALYLLQHRGQDAAGIATCASGGRMYQLKANGMAAKVFHDGAKVANLPGSMGIGHLRYPTAGSSANAEAQPFYVNSPYGICLAHNGNLINAPELKRYLDLEAHRHINTDSDSELMLNIFADELSETKKARVNQEDLFSSLSRMYERCEGGWACTAMLAGFGILGFRDTYGIRPLVLGSRPSLDGKGTDYMMASESVALDQLGFSNHRDIQPGEAVIIEKGGEPVFRQVAPKKDYAPDIFEYVYFARPDSVMDGISVYRSRQRMGDKLGARILEVLGPDVVKDIDVVIPIPETSTTSATHVAQFLDKPYCQGFVKNRYVFRTFIMPEQKTRQKGVRRKLNAMKQEFKDRNVLLVDDSIVRGTTSREIVSMAREAGAKKVYLASCAPEITHAHIYGIDLASPSELVAHNRDTTAIAHHIGAESVIFQTLEDLKESCAEIARENGQSEPTNFEVGVFCGSYVTPVRPGYFEHLEQVRGEGRKIKVVDKAKDNVTHGVADMNDFKIVANGVTVDTNGKIIPAESPQPVQKSESESHPKVDDRMDISIHNIGDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UME3</accession>
    <name>A0A1Q5UME3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UME3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="70" mass="8292" checksum="19B1CFA22CBB0CF6" modified="2017-04-12" version="1">MMMMLWLRLPQRDLRFGSRGFEAPIKEGENKPEPSRWVSLSSVIVTQNVLGLAIVDGWDEWEWNIPEYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMF7</accession>
    <name>A0A1Q5UMF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMF7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="167" mass="18652" checksum="B606FEA10AE677D5" modified="2017-04-12" version="1">MLGYAAVFGLKESLHLNGTEYSWLGKPESLLILFEPAYLLIAATWYAVEDQPIRIGWWSTYLGVVNSFGDLLAFGVGHIKAALESWQYQFIFIGAISCAWAVLMAFTPQQREYSTLNGEPIKKGRQLIAPDHGLTKTRGKPQSDAWDQDITVQILMRSRSAKLLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN47</accession>
    <name>A0A1Q5UN47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN47"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="521" mass="58877" checksum="68AE0795F7F917B6" modified="2017-04-12" version="1">MAVISEPISFASQHVGGILLLLGALYLASNYLSLGVCSVPGPFLAKFSNLWRFIDVANGHAEATLYELHQKHGDYVRLGPKVVSVRDLDALKMIYGINKGYRKQLAKGKPTPTLFTTTDEDFHAAIKRPISGAYSMSTLTEFEPFVDQTIHTLFGRLDEFVTRDEVCDIAVWLQYYAFDVIGELTFSKPLGFLEKGADVEGIIEALEHMLDYSGKIGQMPWLDYIFIKNPLRRLVQGGSTGAVARFARARLDERLMHSESTAKDNRDPTQSHRDFLARFLEAKKKYPDIVTDNQVFSYTVSNMNAGSDTTAISLRAILYYTLKSPRVMAKLYEELTTAYQERRISLPVSWKQSQDELPYLDAVIKEALRLHPAVGLLLERIVPTGGLQLPNGGPFLPAGTIVGANPWIIHRHSIFGQDVEFYVPERWLRADGESETAFHARRQDMFRATFTFGAGPRTCIGKNISLLEIYKLVPSLFLTYKLTSAVLQIDLEHPEKQWQTVNAWFVRQKNMHVRLARHDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNC8</accession>
    <name>A0A1Q5UNC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Brefeldin A resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UNC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1164"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1206"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1249"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="112"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="801"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1433" mass="159921" checksum="BA8B6C7967AD87E0" modified="2017-04-12" version="1">MEEHSEEKEYDSTSLPGTATEEGNGNYFNTLTVPEINLREASSAETLTPHPSVVPPPKRNPEWHMTPQVIRNAERDEAAGFKKRELGVTWHDLSVEVLAAEAAVKENMISQFNVPQLIKDFRRKPPLKSILSNSHGCVKPGEMLLVLGRPGSGCTTLLKMLSNRREGYKNIAGDVRFGNMTPEEASKYQGQIVMNTEEELFYPRLTVGQTMEFATKLKVPYHLPGEAKSVAEYTAETKQFLLESMGIAHTADTKVGNEFVRGVSGGERKRVSIIECLATRGSVFAWDNSTRGLDASTALEWAKALRAMTDVQGLSTIVTLYQAGNGIYNLFDKVLVLDEGKQIYYGPASEAKPFMENLGFVYTDGANIGLTVPTERKIRPGWENRFPRTADAILNEYQNSATYKNEVSLYIYPDTQLAAERTEAFKESVAWEKSKHLPKGSDLTTSFWAQLMSCTARQYQILWGEKSTFLIKQVLSCVMALIAGSCFYNSPDTSAGLFTKGGAVFFSLLYNCIVAMSEVTESFKGRPILTKHKSFAMYHPAAFCLAQITADFPVLLFQCTIFSIVIYWMVGLKHTAAAFFTFWAILFTTTLCITALFRFIGAAFSTFEAASKISGTAVKGIVMYAGYMIPKPQIKNWFLELYYTNPFAYAFQAALTNEFHDQHIDCVGGNLIPSGPGYENVGSGHKSCAGVGGALPGADYVTGDQYLSSLRYKHSQMWRNFGVVWAWWGFFAVLTVVFTCFWKSGAASGSSLLIPRENLKKHQVGNDSDEEAQNEKRAARITPDEPVQVDDENLVRNTSIFTWKNLTYTVKTPTGDRVLLDNINGWVKPGMLGALMGSSGAGKTTLLDVLAQRKTEGTIRGSILVDGRELPVSFQRMAGYCEQLDVHESYATVREALEFSALLRQSRDIPKAEKLNYVETIIDLLELHDLADTLIGTVGNGLSVEQRKRVTIGVELVSKPSILIFLDEPTSGLDGQSAYNTVRFLRKLADVGQAVLVTIHQPSAQLFAQFDTLLLLARGGKTVYFGDIGDNGATIKQYFGNYGAICPQEANPAEFMIDVVTGGIEEVKDKDWHQIWLDSPEQQEMITELDRMIADAASKPPGTVNDGYEFSMPLWEQIKIVTQRMNVSLFRNTAYVNNKFSLHIISAMLNGFSFWRPGPSVSALQLKMFTIFNFVFVAPGVINQLQPLFIQRRDIYDAREKKSKMYSWVAFVTGLIVSEFPYLCICAVLYFVCWYWPVWRLPHDSDRSGAIFFMMLIYEFIYTGIGQFIAAYAPNPTFAALVNPLIISVLVLFCGVFVPYDQLNVFWKYWMYYLNPFNYVVNGMLTFGLWGQKVTCNENEFAVFDPTNGTCGEYLADYMSGKGSGVNLFNPDATSGCKVCEYTTGSDFLQTLNVNHYYYGWRDAGITVIYAISGYALVFGLMKLRTKASKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UND1</accession>
    <name>A0A1Q5UND1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-cyclopiazonate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UND1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UND1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012186055" evidence="1">
        <location>
            <begin position="26"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="466" mass="51118" checksum="39F68996A1A51139" modified="2017-04-12" version="1">MIMFSPSSKTIALLGLLAHASFVYSQPDALIRDVAIIGGGASGTFAAIRLRNEGKSTILIEKEAILGGHTNTYQDPVTKVNVDYGVEVFHNQEVVKDYFNKLNVSWAIASDFGGVGTPVYLDGNTAQKIAYTSPDPRAGLYAYATHLAQYAQLEYGFFLPEPVPEDLLLPFGAFLDKYPDIGNAAFTIFRFGQGLGDFLSQPTLYVFKNFGLDIIQDISTGFLVVTSQNNYEIYDHATKILGSDVLLSSTVVSTRHRDQKGGVLLEVQTPSGRRIVKAKSLLITIPPKLGNLRAFDLDDRETALFGAFQNTGYYTSLVKNTGLPAGFSSLSVGADTPYNIPDLPGVYTVDSTAIEGVFDIKYGSPHGLSDDFVRGEILSYVKKLQANGFAEKVPGEPEFVRFNSHTPFELTVSQDLISGGFYERLYGLQGYRGTWYTGAAFHTQDSSMLWNYTDSYVLPSMLSWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNM6</accession>
    <name>A0A1Q5UNM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNM6"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000006">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="226"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="497" mass="54510" checksum="537DF91E5A1E7C0C" modified="2017-04-12" version="1">MSSALLDEATRIAREFDYPADRVQRGVEEYIKQSNEGLAQENTTLSQIPTFVTAVPNGTEKGLYLAVDLGGTNFRVCSVQLHGDTTFSLTQSKIMIPRELMASGTSKDLFLFLARQIEAFLRIHHNEHFEAHLRRRRDGNDVEDLFDLGFTFSFPVRQCGINSGTLIRWTKGFNIPDAVGHDVCALLQSAIDELHLPVRVAALVNDTVGTLMARSYTSPGETGTLLGAIFGTGTNGAYVEKLDKVTKLKNMKDAHYDTTTGEMIINAEWGSFDNHMSVLPDTVYDQELDADSNNPGVQMFEKRVSGMFLGEILRRALLAMHNNPELGLFKTSKTSNVSLPSDSLFYRQWGLDTSLLSQVEADTSKDFVDVKAALKDHLKIENPSDAECQAVKILVHAIGKRAARLSAVPIAAILIHTGKLETENMVDVGVDGSLVEFYPKFEEYIREALREVSQVGVAGDKKVRIGISKDGSGVGAALIALVASKDENLRSPNGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPR2</accession>
    <name>A0A1Q5UPR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_14074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="37"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="175" mass="18987" checksum="670E5FDBDE22C998" modified="2017-04-12" version="1">MEEENGFQIYNEGAAPERAVQALVTQNELPPPTQMRQAMIVGAGFIVMFMASAIIFAYGVYQVIYEEMAKQPRTPFTGTSSSIISLIGTLSITVMSMGGPFAMTWAKLYGPQPVIMSGGIVFGLNCILASLSEYVWQFALTQGVLVGMGTCMAYVPTMSVAPTWFDNRRGLAWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQV2</accession>
    <name>A0A1Q5UQV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Life-span regulatory factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQV2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="37846" checksum="FC70CCB7FA7F07D6" modified="2017-04-12" version="1">MTQSTTSHHRRSPSSPHTIIPKSKPAVRPGLHRRGTSGVSLSISKLGSGHHHHHSSYIRSHSRGINKADDDFDMAASFLNFCAMCERQITIPNNTILYCSESCRRKDSAKPLSASLPSTSTLSTRMSSTNTKTYTYSSTTSPPTSPPLSPRTIVAPMTPTVISSSTPVPSIRIPATIHDGKSDLDPTEWKPVLGARTDSTGSTTSTTSTTSGSSLATSDAWGYLSQFHGGSSTFLAPRSHRSTTSLSTLDVTGTPSLTHAPSIASSVSSTASYEPEHELGHRPLPPRHNPFFSLSHAAEKGMALVVPQVEAVAVQDVESDSGSIFPASSSVWEDGVTTATKGSAPIMVRGRGRVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URA2</accession>
    <name>A0A1Q5URA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URA2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URA2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF32">
        <property type="entry name" value="SULFATASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G17610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="443"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="858" mass="97887" checksum="4243A931959F3795" modified="2017-04-12" version="1">MKLSIRQRCLEFIRVLLSPTLWFDVYWPASRKYWFSLLLIGVICAKLLHIYSHLNSLSPGQFILWGPTFFLQDVVCIIIAQTLSQNFQRRWLRVVSAPIVILTSLMISGLAAANISFYTQTGAEIHWRQAHAFHRDAASVKTLLAGLTGILIMEVLFSASAWISTPYLYNWVSAVTRVLHVAATPLFFCWKRKPRSDPENYAQVANKDWDEEDPESEAMLGMHDPMAASQSSSSRPLPSLLLRILVASVTAFVLLLRCIRPSDTAYSFLSQTVIVTPFEKPPQHETTYSVDLPPDLPGDYSWLYNHTALAAPTKFDWLPSKKIGGFRDWYEEGKEGTALHYDPAHDPLKISNLDREVLEPWRDALKSGSVNIKHVFLLKLESTRYDVFPVRKEGHVGDIIRESYGGTVPDIVDQRLANLSRNAERLTGVSAGWDHSDDSWKPRGGMYASNAYTGDTFTLKSILASVCGIAPLVVDFNKEYLHHIYEPCMPHILHALNSMSRENDTSKVKENDYTTWPWHSTFMQSITDNYDNQDLLLPALGFKDKITDKKITKDWKKKPGEGPKKFNFWGYPEHELRPYFIDALKHAEKHHERLFLTHLTGQTHYPWDMPKGDTIEEFMHHNIFNGRNRMNRYLNTLGVADRWLGEVLEIIEEAGVANETLVVMVGDHGISLIEDGGVTPYDNPHVSNFHVPLVFSHPQLPQITIDGRVTSMQIVPTIMDLLVESGSLDKDATHAIKDLLPLYEGQSMIRELVPEKDGKLDWQFTVMNTGATWLALRSGPKPYRLVIPLVPDVEWRFSDVDKDPLELHTVQSFTLPPLLEEVAKVHGEDAVNWVIEAAHVTRWWVSENWRRYEYKPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URA3</accession>
    <name>A0A1Q5URA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3402</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URA3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URA3"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="482"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="354"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="654"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="707" mass="77263" checksum="0D6635712273C417" modified="2017-04-12" version="1">MEVSEIQGIRVAVVGCAHGAFKEIYDLLKAEAQAKGWETIDLVIIGGDFQALRNANDAACISVPAKYKSMGDFHEFYEGTSVAPYLTIFCGGNHEASNYLYELYYGGWAAPNIYYLGAANVVKFGPLRISAMSGIWKGYDYRKPHFERLPYNGDDLHSIHHIRELDVRKLLQIRTQVDIGLSHDWPRGIENYGNHQELFRKKRGFREDSEHGKLGNVAARDVLDRLRPAFWFSAHLHVKFAATVPHDGVTLKRVPLSADQPTVWAVQAQTAADSPKGGSSTMTSPNPTSSGHTTSDERVTSMTQAMVSNKILPASGTKENKLNAWNNFAAGGACAFEAQERIKIEDHIANLRRENDVRHEREQELKAKAQKDEPAQSNVDQPAPGINQDEIDLDSGSETGRAVSGNPSPVKANQDEIDLDSGSEAGKTASGNLSPVKLPKLNIASSDGSSDPPASEPLLDRAVAEGLRGKLPASFSHPVAATNPTHKKTIPTAIANKVTKFLALDKPHNRDPFMHLVKVNPVNPSGDHPLPGPFRLEYDKEWLAITRVFANDLVLGDITAKVPADQGEDYYLKRILEEEEWVEQNVFRGWPHEIPYNFQPTAPNFDPSVPLTSVEQPKEYTNSQTAEFCKLLQIPNPFDLPEADRQARMEAGHRPMRAGHGGRGHGGGGRGGGHRGGGHRGAGRGRGGRGRGGGRGRGASHVDTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMN1</accession>
    <name>A0A1Q5SMN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SMN1"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1382"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1670"/>
            <end position="1957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1973" mass="219384" checksum="3B8B576A8A8C3F59" modified="2017-04-12" version="1">MDGLSVGIRRSAFEKLAALAVKSPGNDDGSDLARLAKQTRLARQPDGALNGVLKEQAPTSRVPMGIRELDVLLALCKAASSVNDPEHANRLVSQLSRYLPESPTQLFRPSPFLHQVKPSPWEILSHSLTTALLSLATEFSSLRKVALNAVSGYLKNCSDAVNAVTPFQYSSSEAGGRGVVHESIAVLSIAVSLVGFLEASAKYTVIWTAGEKLQIIDLLRSMLSESFMIAVETASSTVRNASHSDASIKDWRKYTRRYAAHGRPLGAMLVQEGFMRFVKSCAASLIGSQNLSDDQLLDEYMAGVGIAKSYDEADIALIERVTDLISEEINLLEDGSDYLQVGSPSQQRLAFSVKGHALVGFLNCVVLGEDAANNDVLLSWLETTVGDPQQMACDELAITALKCTAILARMSSNGATLGRRCLLKYLVHGRASKGSVVAVASRCLAQILSILSEDSVIATLYSLGNSLSPGPKGDQANQDHVLVDSTGITGNLVAYAHAGNASQATLSALGEEETLTNRNIVHAIVIIATSCNDDKISALAQSMLLQKVGKINVSVDAFIIQEAAVLALSSGQPEFLLLLKFYNRIYLDGVHKGLDMITDAVQCAMSYLSATLDGNSPLHRLYLTHLLESVVNKGDVPDVGESERHREVVFAHGDITPLLKPLALLVSSKKATMETCNLTLGYDEAICSLFRDAWFNIAIHGISLNSSIYHKHLKELSLLASHSPPLVAEERMESLESDVELNTVLRRGTGPQRVLEQKRSLIAELPGRESDIKRLDYPRSVFLNAVLLVETLRSASGDCTKVLNYFRDPAVAAPEMVICMNAVADKVVTCYLSRTLSGEFDEFSAPYLAKQLANFLTACCHRIERIQHIATQCTDKIIRECPSALCEKHSLFALLEILTVMWLSCLQGELDEFEWKPTLVSPMGIVKVDLPDNYALRKATLNRFLERARTWVTTVLNIAPLDIKGLLQTYLSEYDDDGGYGHISLGRSFALEMGSLIPRSDPRLGSIDSHESEVNVASDFMALYTTRQKYRRPDISLLDNADGLNFGIGGRKSESDFSTESANALEYSLARLYGRSMKGDEIPLGEVRDALRQAARLICSSSNPRLSVVHYLVALPFQIFTKDTIKLGVSLWLGVIHENPSVEPRILAHVVEAWDKSIQRRQGLFDPTFDYLDPLQTKIELLPTDKASMLRKQQEAQDTLSPHLRVLQFFESHFSAVRLGNLQDQQLFCRLINNTLVALTKTKGHPLAREIHFRIVLFGLRILQHLSPRNGAATWKLKDQILSAALSWFKHAPRWSFGGNRLQIKAEDKVFSDVLSALRNVADIATQVQGSYKSLQSKQELTQILIENERTRLRVWLFPLEPERKHHIPGIGGSKNSTDAVTAYLRLAWAESPGLAIQLASRFPSIKMQTEIRWLILNFPEKAVHEPSALEIMFDSSLQPDVNFQLKYLLYWAPVNPTEAITYFLPAYGNHPFILQYAMRALESHSMDIRFYFVPQLVQALRYDALGYVERYTLETAKQSQLFAHQVIWNMKANSYKDEDSQVPDPIKPTLDRFLEALISSFTIEERDFYEREFSFFNEITGISGKLRPYIKRSKPEKKQKIEEELRKIKVEVGVYLPSNPDGVVVGIDRKSGKPLQSHAKAPYMATFRIQKTRPRLEGKGDAAKAVVVNGTEQRQLGSRQGEQDQETYEVWQSAIFKVGDDCRQDMLALQMIAAFRSIFSNVGLDVWVFPYRVTSTAPGCGVIDVLPNSISRDMLGREAVNGLYDYFVSKYGGEDSIRFQEARTNFVKSMAAYSVISYLLQFKDRHNGNIMVDDAGHIIHIDFGFCFDIAPGGVRFERAPFKLTSEMVAVMSGTHNPAHHPSGTSGISLPGSNSHNPTTTQPYRWFESLVVKAFLASRPYCTKLAHIVSLMLDSGLPCFKPETLKNFRDRFVLEKSERDAAEYMRELVRKSYMSVSTKGYDQFQLMTNGIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNU9</accession>
    <name>A0A1Q5SNU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNU9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16015" checksum="3F21B7D31E05301C" modified="2017-04-12" version="1">MSSLRPCQLTYSLGLLCTAITRIALWGTDILARSLFLTHPIQPRLLADVPDQRSSSTDACTTDPRIRRLARTESEESLSSSIFVGNIDKLFDDAGENSPTQKPAKISDLSKNGVYTPPTKKLEKVHYVPDNTSADINHTFHTLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQR8</accession>
    <name>A0A1Q5SQR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQR8"/>
    <dbReference type="OrthoDB" id="3590765at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202770" evidence="1">
        <location>
            <begin position="25"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="499" mass="54691" checksum="EB65DACDDF3A8FED" modified="2017-04-12" version="1">MQILGLFKLTGALFILSMISRVAAAMASENIFRLSSLGGLIVGQHFQANADAGEHDTKPLKEAWGLRAGVYTPRQLVEGFAPLLDAVVFRLGTDPPNSKPARTQLLDNVAANLATDTRESTLRLVEPLDISRREIKDQANRIGKTLVQWARESSSKSFNPDMSLRSPCEGHLLTRPNVDLMFGDRAAPPLMQLFNEYMHQMVLLRDALLPFQNYQDVLIPVDRHARGIRHLEAGRSKFLAEVLTKHATQQGVIAYAKALLAPGLLSNPAVGYGFQYAHGTVLPAFLAGGPTSLHLLQYLPTKIDETTTEVSFEYKFQDYYSAHRGEISEGSPTPASQMQIYPETKATNVKSAVIDVSIASKPTSSRLLELRLELDNEKCISVDLGQIARGHRYSYPIQNAPDKEVSKFTPEYIVHDALRILQSETGGLLSAQEGGVHVIPVKDPVIALALLGKLYPENVVLLPGSETLCKAESAGKGFEPKFVIWGGSRRGGVKGVFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS77</accession>
    <name>A0A1Q5SS77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein 8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS77"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="17326" checksum="DC25BA58B9B67005" modified="2017-04-12" version="1">MSNEMEVDLPVAQDDSPAQDGRGVEPRTQTGAVAVRSIEGWIVMVSNIHEEASEEDITDIFAEYGEIKNFSLNLDRRTGYVKGYALIEFSTLPEASEAIKNLNGSKLLDQTLSVDYAFVRPPPSSKGKNQGQKNIRGAAARGRSRSPERSRSPVGDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSA8</accession>
    <name>A0A1Q5SSA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSA8"/>
    <dbReference type="OrthoDB" id="4369908at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012795835" evidence="2">
        <location>
            <begin position="25"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="342" mass="35551" checksum="B4DDB4ED9157179F" modified="2017-04-12" version="1">MFSTGYWALLAVSCVLFASFPVHGQDLAIVERDANAGLEQLVDPDLRGAMLIARGSDNDGTDHTSRGPHTTTIVTTNPIETATMLVERRDVPDQSSHGPPPPIPPPTITITRTQPASTAICELATALCAACPPTVVTVSACPIPLATVTVTSCPFDTVTKTVTECFSTTTSTSTSSTRPASSSATATPTPSSSIRPSSSPSIIPSSSSVIPSSSSVRPSTGTGNSTSTTRSSTPMGPGFSSTIPPRTTSPTLSTQPTSTTASTARTTHEGEGGGPSTTRRGPPGIVRREMMGNITAIVTNMTRTFSNATTDPPLNLTETTVNITTNTTGVFLPRFHRARLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUC4</accession>
    <name>A0A1Q5SUC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUC4"/>
    <dbReference type="OrthoDB" id="4256056at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="389" mass="43960" checksum="E5BDFA84BAABE6B9" modified="2017-04-12" version="1">MPFDQSPFTQTSSTSGRYRNSRFSLAQVEIPGYTPRATHETWTMQRHEDFLREKHTRVLSPGASVVVEPEFYHTSRFDSTLNLEKQVFRYMVDLNMDPRSTSRHRRIEWPTLNPTILPHLAGGPLTQRPASALAPIPEAAAAVVQKEILKCDFKQVIIADLNIYDEASIRIPHLESILRNLWWRGRRQSAIWVLFQILVARGFIDPACLQRPVDLLRRTPSTSLVTGLLGCFSGVHTDVSLAFDDKISLQSVEWAADVQWLATMIVRTGMELDNLFDTIAATKILGQCDEEILALYRLMYPIAELPAEGRENEREGTLLPSGEVPPSRNLFAFWLPHGVSANDEARNTQISSCLARFDAIEKAYRQTEEIPENDPVFTGDPEEGNRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV49</accession>
    <name>A0A1Q5SV49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV49"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SV49"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="272" mass="29635" checksum="B70BCAFD5AA36BE0" modified="2017-04-12" version="1">MQVLLLGGHGKVALHLTPLLLNRAWNVTSVVRNPDHEKDILALGNGRKGNLNVLISSLAEIKSAADAQKILNKVMPDYVVWSAGAGGKGGPSNTIAIDQEAAKHFMTASFASTSVSKFLMISYLGSRKNQPHWMPDDQWAGVVRTNTEILPTYAKAKQEADEYMTALAFMRKREPAATRPFQAINLRPGTLTDEPATRKVELGVTAKGRGSVTREDVAIVADLVLARDDVEGWIDLVNGEEGVEEAVERVAREKVDAVEGEDVEGMVKRFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWC8</accession>
    <name>A0A1Q5SWC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF49">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO92319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="393" mass="44651" checksum="553D372783818522" modified="2017-04-12" version="1">MLLAAQILCGIPWGVFQTLSTTYAAEVMPITLRAYLLSNVNLCWVLGQFLATGIQRKFVDNKSQWSYRIPFALQWAICLPILVAVAFAPESPWWLIRHKNQREAERSLMRLTRKDKINIDQTVALMKHTNEIEKYLKEDDKGMSYLDAFKGVDRRRTEIACMVWVAQQICGTSLMGWASTFYEQAGFSIDNAFNLSLGIYALAIVGAVISWTLLSRFGRRRLYLCGLSALLTILLVGGIVGALPTSKGQLWTLGSLLLILTFVYDMTIGPVCYVLVAEIPSTRLRTKTVVLARTAYNLAGILINWMTPRMLSPAAWDWKGKSCFFFAGTTALCLAWTYWRLPETFGLSYLEIDILFDRKAKRSKFRELRMNLESSGYFSIVNSPRETGIWRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXC1</accession>
    <name>A0A1Q5SXC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">37S ribosomal protein S24, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXC1"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="191"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="44188" checksum="EF7BE5562AC1D7AC" modified="2017-04-12" version="1">MACVARSLNRSARVLAQRGPGFIPTRSFSVSPFRFVTEDPVLPPPPKELKAEDYPPVPEYSPDLLTKGERSMYDMLSPEERAAFDAENQRIVADFNDLEKRAAAFAEIQKSVDQIDKQEDIRFEDIRSKVRGFWAEDDGDEMAQVEDGDEDIQDDEITSMAHAEMELHREMREYARIAAWDMPMLSKLAKPFTLPPETHILRFRYTIYMGEQHPAEPKVVVELASRDLTPKYLTEAQRQTFLKLVGPRYNPQTDVVKMSAEQFGSRAQNKRYLADVVNSLIQEAKKGDSFADIPLDLRHHKPKFRPQFPESWNMTKERRQQLAARRKERLTAQSSREAIVDGNQIVSEAVLALPELNPALKARAAEEREKVAVKVGARPSKRPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXP9</accession>
    <name>A0A1Q5SXP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXP9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="508" mass="58273" checksum="5304A3DB62EBA3BC" modified="2017-04-12" version="1">MPGDRAKSSLRKKTHWVIRDRKKFETRIFDAKAYIDSLQEITKNLHAHTIQHQQEIMTSGIRRIDDTRALEWLSEVCGVDYPELSDAATSKAETITQVSVAGNELQDQRAIKGFMSENDEDSDTLSLNSVITSLEDMTVTESKYELSTFRLRAKRRAKEATARGQKIQDEPEKLPYDDESEEEWNSVTTTIQNPSQQGSENRSSRVADTTKASTDEEFHEEMVAVVRWFTALSLEERDCSLLRLERQFEQYTALEEYNGGLLESSASQPEEDASDGHMADMIRAIECEEFRDEAKAILSWFRVISHAERAMTLIRLGESLFIDPYRITLSTSQKQRWFEHWSKFDTTPLDLRGWLAKQGDKEFAENPEKFMEFMIHASQLQKFREETDAPMAWFTLLPPTESAVALLRLRECLSTDLDRLILSLDPTHQNQDGKHRTSSQESGVTHQQLASEFQPTPWDELKGRSKTNIARYSNILPNPASASPSTDTEEHRQSPVPPDTALYTLEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0D6</accession>
    <name>A0A1Q5T0D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0D6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0D6"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14178" checksum="1BAFD9EF07E1DEFE" modified="2017-04-12" version="1">MAPKNNAKGGDKKGAAGKGKGKDAGNDDKSKVKGAQSINVRHILCEKHARKEEAMEKLRNGTKFDEVAREFSEDKARQGGSLGWKTRGDLDPAFEKIAFELEPSTTAKPKYQEVKTGFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0J5</accession>
    <name>A0A1Q5T0J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0J5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0J5"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO93797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="535" mass="61771" checksum="E097D75030CB23A3" modified="2017-04-12" version="1">MSTAVAQHDPSVLRPRAIPNQPDTKADATLTPPMLDRLSSDASGYSTPIPEDAPPSAQSIAVARKQVRARNRLFYTIDYVPRVSHFDPDSDYHNFRGFFTLFWISLVIMVVTTMLRNIKDTGYPLRVRVWSLLSANVWELGLTDLAMVASSALVLPMHKIWRSGPRWLRWARGGMILQSIGEALWLAVWINWPFMRLWTWTAQVFFTLHLLTILMKLHSYAFYNGHLSETERRLAALDKPGPIEPSSPAAIRYPEPYRRRPSMKPQHDDDDSTEPLARLREDLATELTSPLGNISYPQNLSLGNYADFVCCPTLCYELEYPRRPNRRWDEIAWKTLAIFGCIFLLTLTSEEFIVPVLSEAHLQLEALDSVTEKALVLAETISMLLFPFMVTFLLVFLVIFEYVLGAFAELTRFADRHFYSDWWNSCDWLEFSREWNVPVHHFLFRHVYFPSRSHFSQPVAMFITFLVSSIFHEVVMSCITKKLRGYGFGAMMLQLPIVAVQKSRFFKGRKTLNNVFFWFSMISGLSIMCVFYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0L2</accession>
    <name>A0A1Q5T0L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoinositide 3-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0L2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0L2"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17666">
        <property type="entry name" value="PTP-MTM-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="137"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="411"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO93730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="748" mass="84270" checksum="65EC1C0D7F3CB133" modified="2017-04-12" version="1">MEKTRVAKVDNVSLARRGDQVDGALHLTPHHLIFSHTPLVSSEDAAKGMTIRPKELWITYPIISFCTLRPAPAASRQLSSIRLRCRDFTFVCFYFTSEQRAKEVFDSIKQWTCKSGRLDRLYAFSYQPPPPEREFNGWDLYDPRKEWERQGLDKENSGWRVSEINTDYGFSPTYPALIPVPSSISDNTLNYAGRYRSRQRIPALTYLHPVNNCSITRSSQPLVGVRQNRSIQDEKLLAAIFSTSRTERPLANFVKSTLDREASDSSHDSGSTTDLDVSNAEEIEDEMLAAARAAHPEERAIYGAQQQNLIVDARPTVNAFAMQAVGLGSENMDNYKFATKAYLGIDNIHVMRDSLNKVIDALKETDVTPLGPNRDQLTRSGWLKHIGGILEGARLIARQVGLQHSHVLIHCSDGWDRTSQLSALSQICLDPYFRTMEGFMVLVEKDWMSFGHMFRHRSGHLNSEKWFQIENERIGGGDAEGGGAGPAKAIENAFLSAKGFFNRDNTSRDSLPDSEGELQSYDSDNPTKKPSSAPRSMVSEKEITKVKETSPVFHQFLDATYQLLHQYPTRFEFNERFLRRLLYHLYACQFGTFLFNNEKERVDTNARERTRSVWDYFLARRDQFTNPDYNPIIDDHKRGNERLIFPRVKETRWWAEAFGRSDSEMNGPFPSTGGAGTESPGSGRAPILTGIETAQQSTGPGPAGTDVHHAAASGISAVTAGISNFGVSKDNNRGSKENEHKQMELEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Q9</accession>
    <name>A0A1Q5T0Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="10" type="ORF">PENSUB_12035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Q9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0Q9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="35624" checksum="28200771F4A3DB09" modified="2017-04-12" version="1">MATPTRPAPSPAALLIYPATLLLGSLFSVISPVARATRESSLRLPKSAAPLAPSLAADLHLSENPVNYFARKNNIFNLYFVKIGWLWTTVAFVSLLLFQPVYRASSSLSQAQQQTRVRRALQAFLRYAIATTIWYLMTQWFFGPAIIDRSFVVTGGKCEEVMERAGKMELGGSPSAQVETLFSAAACKAAGGAWRGGHDISGHVFMLVLATAFLAHEAVGAGAFSAFSAPTRADGDSARERKASGPVVSGLMNDETDSGLARKWSLRLVWGVVGLGWWMLFMTAIWFHTWLEKWSGLIVALTSVYVIYILPRRLTPWRDIVGVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0T1</accession>
    <name>A0A1Q5T0T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T0T1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008626">
        <property type="entry name" value="Mediator_Med15_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043540">
        <property type="entry name" value="RING1/RING2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05397">
        <property type="entry name" value="Med15_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="7">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1361"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1532" mass="169238" checksum="A55E49E84D7B8E25" modified="2017-04-12" version="1">MNPAQFSNPGGGMSGLVKPGMSQQQSQQQRNENAQLIMSSVAQELQMQPRLGGWKDEVPIKVRAMNVYQMITSLRLIQPRIDLKQAGNAAIAFETGAFKKAAERSDYEKDCNEKLLHIKDTRQRQAAVAIQSGMMPQGGPAMQNQLQGGFPPQMNPNMQASPVAPGQSQMAMGMNGPNQQAAMQQRQQQQQQQAMLQQQQQQQHHQQQQQQQQQQQQQQQQQQQQQQQQQRAQQRPPNGLLLPDDVTGLQNPEAEHVIRLADQMMHKTSPADVEKIKLNLANMNPEQRDYLQRQGIEPITYFFRTQAVTQLRRFRNRTGMNMGRPANAANANADAMLTGDPMMNQQAMFQNMMNLQRSNSTFSGNPAQGQDPNAFFGNVENIQGQQADGLRSQEAGQLVVPASSSQMNQAPFNNQQNLFPQQSGQNGQGNGAMNGMGMNPQMFSQQQMQQGLPNGAQQFQAQQAQAQARAHAAAQKAQLAMSGQVNPQAQAQFSQQSPVMPMLNQGMPPGQISPVPMAAQVRPPSRPANMGQHPGGMQAAQPTMQNRPQIPPNLPGPIQEQLSGLTNEQLHSFLQTQRRAHANNLTRANLQQQQQQQQQQPAPQSQPQQQQQQQQGSLPQDVQNPAMFNGQMVNNPRMRNSMSMPQGMNMAAGLLQNQQQLTPQQRAVRQQRQTEMMKLNALRKQNNGHEMTVDQQKEMDRVPFPPSLVANNPHVPQHIKTWAQIKHWASTNPVTTTGVDFNRLLTLQKLHFAQILATKIAQQQNQQNQQNQQNQQNQAQIQQAYQGPQNGMQIPQNHPHPGMNIAMRPITNEDVQSARQKLGSNSSNYTDDQIRELLRNKQRQMLEQAVQQRALAMGRAVPQPPGVVPQKQTQVPPVPVAQQPPQVTGDLQPPNPRPQQAAPAPKGGKAPTVNQRSKKRPNQDDIVVEMPVMNTTPQQPQATPIAKNSVPQKPVPNQALSQEGLAAMTPEQRLHVEQTMRLQQQALFRGQYFNRAVAESNWKNNLPPKLLDIYNEISKAAPAPNIVTVSPEQKAIMTQQLQDSLEVLARLDILVLHGFQKAANQERNIRNLLAMRIQLMRQFKNTPEWIINDHFTITPDYLTGAIIFVRKLFQMTLVRITNERQSALNRANTPAAQSEQPTQTTPLNANNLKQLQFQQQQHEEALQRARRASSQSAPVPPAPFGAPSPQGVPAYGSGGLAPEKLKLPPPKKRKQSQTGVSSSPVPASAPLIADASYKKTVADAKSAAAPLVGTFKCGIVECQFHFQGFPTQAALDKHVEESHKPEVVEVIDDPFQFYIDSLDIGLGLTADNQGANQVVTTSAGPTGLMASPVKPGLATPASSTATPMLRAPSQVVAKSASPATSAQQLTPQQGKAKKPGSKPGALDLPSEPALPWANSHMTPQELADTFDPLFDDLDDGNGLNMFSDEAFNNNAFLGADPTEDTPDSNDLALAIQTPQDDPINWSEWAEYDEESARATAEWMNIPLELQDNSGDGIPGVRVDFDRLEREQREEKELALRGGRGNLVISTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T114</accession>
    <name>A0A1Q5T114_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neutral ceramidase</fullName>
            <ecNumber evidence="5">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the neutral ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T114"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T114"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="8">
        <location>
            <begin position="613"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="782" mass="84549" checksum="97B409FE71512F91" modified="2017-04-12" version="1">MANLRLGAALGAVAVTFLVFLQLIAVMQHADQVPVSSFNKNLNHWRNRAGAATDDGLFLVGAGKADVTGPVVEVDFNGYASLDQLGTGLRQRIYSRSFIFADPKNPDNTFIYLVLDTLAGDTAVRHGVLQGLAALGGDYARYGEHNVALTGTHSHSGPGAWMNYLLPQIPTKGFDKQSYQAIVDGTILSIKRAHESLTPGRLSFGSINLEDANVNRSPYSYDHNPEEEKAKYSANVDKTLTLLRFNRESDNKTTAVLTWFPVHGTSMYNNNTIVTGDNKGVAAYLFERSVENDSRFADGAVIGFSQSNVGDTSPNVEGAWCEDGSNVMCTYSDSTCGGSSSRRSRDLSSGLSSRATGTNEACHGRGPFFREKDNGAKSCFEIGKRQYSAAKALYGQLSSGSTGTALTGSSDVRSFHVYQDMNGYTFPSPFNGSSLKTCPAALGYSFAAGTTDGPGAFDFTQNASGPATENPLWKVARAFIHQPSAEQEKCQGAKDILLDVGTLTEPYAWAADIVDIQVLRVGQLFIIVSTSEATTMSGRRWKAAITQAAKDTLSVSNPQVVLGAPSNSYAHYVTTEEEYNVQRYEGASTLYGPSTLAAYINLTLTYLPYLGSASDIAELPTIPTGPSPPINTNNSLSFITGVVYDNAPIGKSYGDVVSNPAQKTYGPGDYVNTTFVGANPRNNLHQESTYAAVERKTDSGSWEVVRDDRDWNLVFNWKRTNTVLGYSEVTLQWQIEDDYYSVDDPNPVQSGTYRMHYYGDSKNVLGQISSFEGIGGTFTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T257</accession>
    <name>A0A1Q5T257_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T257"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13273" checksum="FB01F5712027E1C0" modified="2017-04-12" version="1">MERVLSFLYLREHSEDGHIIQYQPISAFAICDHESDSSVSDTTPVPSSQHASVDAKSVNMGRAPCSRKGLSWSDEEIDLLVKLREEENIPWSELTEQFANVVNEDLAVIAKEVVRDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2M4</accession>
    <name>A0A1Q5T2M4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2M4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="5815" checksum="59C5F1480E98DCF1" modified="2017-04-12" version="1">MQDKTLHIALVGLGLELESGGNTQKKGDVPEREIMSEGRDGEESGDDLSCPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T3Y8</accession>
    <name>A0A1Q5T3Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T3Y8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T3Y8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13349" checksum="708C5E988C409575" modified="2017-04-12" version="1">MNSRRGFISMPPVNLGLHFDGIGSLPRLKLRPQIARKMLLEAHKWTGKEALEDGIVDEIAEPEKMLDAALELGNKVAPKARMGVYALLRQELWGDAIKKFQRISYVHSRMTTAPAKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4R8</accession>
    <name>A0A1Q5T4R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000705">
        <property type="protein sequence ID" value="OKO95221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4R8"/>
    <dbReference type="OrthoDB" id="4314155at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="207" mass="23321" checksum="84DF03E46EEC295D" modified="2017-04-12" version="1">MISTDGSCHYDTYRLSERLEFKQLLCIMSYALISSTVSDLDENKRLLDEYIQRDENDWEPRIDQATLAKILSTMGALGSDNTEIDIPANGYSGISLDDLHAQAQYILWRLKQISAECLDVLQIESARDLRRPIGGLLSFIIACASVSVHVDYLPLSVHLAQNERSLSIMQHQLQMSPLFAAGLDIDELDSALNSLDLLFTEEELREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5R6</accession>
    <name>A0A1Q5T5R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5R6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="133" mass="14506" checksum="BC91CF2FB390EAEB" modified="2017-04-12" version="1">MSLSFSPGQRAVLDLRTAEWGNRVNDYVSTGTQNLRANNEQSTIHTHNTTWQSEGPQFTHDSQTHVGTESTTARHLIFPEMADRTTIYSTPTTGEDGITDNRTGGINHGALASDGSTGHQVGSEFMPRNSQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8W1</accession>
    <name>A0A1Q5T8W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8W1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8W1"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO96640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="479" mass="51600" checksum="C9B507A02B8C8E06" modified="2017-04-12" version="1">MSALRLAARRVPCASRLVPYFESPIQRRFAATSNAPQEVKRQVQKEATVPNPDPSPDSLTVSFINERAPFMVPTYVRPAPMMMKGQGCYLWDMENRRYLDFTAGIAVNSLGHCDPEIAQIIAEQAETLIHASNLYHNPWTGALSQLLINLTRESGAMRDASQVFISNSGTEANEAAIKFARKVGRSIDPSGAKHEFVSFHNSFHGRTMGALSATPNPKYQTPFSPMLPGFKYGNYNDVEQLQTLINENTCGVIVEPIQGEGGVNVAKPEFLAALRKRCDEVGAVLIFDEIQCGLARTGSFWAHGHPSLAPASGEAAHPDILTTAKALGNGIPIGATIVSGKTVASHIKTGDHGTTFGGNPLACRVAYHIVARLADPELQSAVQEKSTVFTSGFQALQEKYPDVISEVRGRGLILGLQLAPAFTSKAADIITAARERGLLIITAGDGCIRFVPPLTITEEQIKTGLKILEQALASVISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAR1</accession>
    <name>A0A1Q5TAR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter SNF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10128</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAR1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF6">
        <property type="entry name" value="MSTA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="88"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO97334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="588" mass="63468" checksum="39CC0AAB7F50CBBB" modified="2017-04-12" version="1">MICGLTASGSSDDSVPKADPHGGTRKNRLEPIISAAYPLLNIALPVAPILDHFLSGPLSYSDPMARLPVGSSDVSNIEAPISLRAYLICGFACFGGLLFGYDSGYISGVEGMAYVKQHFGHAVPLSMDSSGYMLASWQKSLITSILSAGTFFGALIGGETAERIGRRLTIMISCFVFACGVAGQVASHTVTGLVIGRLIAGFGVGGVSATVVLYVSEISPKKIRGMLVSVYQFAVTIGLLTASGATQGTSNRNNSGSYRIPISLQLIWAAILALGLFFLPESPRYLVKAQELEKASVALSRVRGQPADSPLIQAELAEIKANWEYESQLTNTSWLDCFKGGLSSPSGNLRRVLVGVFAQMFQQWTGVNFIFYYGTTFFQSVGMSNSFLMSTIMNIVNVVCTPISFWTIERFGRRTLLLYGAVVMCVCEFIVAIVGTADEGSKAANMCLIVFTCLYIAAFASTWGPACWVLVGEIFPLPIRAKGVALSTASNWLWNCIIAVATPYMVDEDKGDLKVKVFFVWGGCLIFCFLFAFFCVSETKGLSLEQVDRMLEETTPRTSAAWKPHDTFAHEMGLTDKDGKTVEETEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB27</accession>
    <name>A0A1Q5TB27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11123" checksum="8E9C0C215AF51785" modified="2017-04-12" version="1">MDSEGSMRFWGSGDGKDGYDAIEEIAGLPWCNGKIAMLGNSWLAISQWFIAAERPPHLACIAPLEGVSDPFREQLRRGGIPELQFWNALLGLLCGSYQFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB65</accession>
    <name>A0A1Q5TB65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB65"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="119"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="41848" checksum="D2AC13F020BAE314" modified="2017-04-12" version="1">MSSSSLGDLPSDTPSTTTTNSSSNSTSRSGSHTPQQTSGASSYSQYFSYPVSHVVSGLYRRLTDPNIPKTTMPSSLPWSTSSSSSEIFTPRRTASPFQPPPLTPLTLTIPRGADLLQQQLLTRALAEEIRLLVPARLQLVETWRLAYSLDRDGASLHTLYDHCQQFSHRSPRAGYVLVIRDSSPSGAVFGAYMTDVPHPDSQFFGTGECFLWRASVLPPPASLGLAFSGDGPQSEEALERAGLPPPPSADTTHAGRWSTFRSDPRAKAKTKSSPAHNLNMNIKTNLAAASGGALAPPSPSSIDTPSRSGASTPERIRFKAFPYSGVNDYMMFCETGFLSLGGGDGKYGLWVDSGLEKGVSSHCQTFGNEPLSDEGEKFDVLGIEVWYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBE4</accession>
    <name>A0A1Q5TBE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBE4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="678" mass="75938" checksum="25AB4D803A5C95AB" modified="2017-04-12" version="1">MFTEGCEDCSLSPVPTTPRNPADEERLAYMRMYHKLHNLEDHPDFLPLAQDMLLSLLAEGLSWERQRPDSILSLGSYSLRSLQAFIKNQDEQVATQWEQYITRRGGGGMRELFQTREESYDWIKQRAPLKLVDGAWVGHIHRVSTPYAERHVTKDAWQVMIEEYGDGSLEMHHVHLYSRLVQEAGVCLPPPDSADFIDPRHGMVNTLVWKAAVSQLLMSLFPHDYLPEILGFNMHFELLTLETMKAAKELEEVGMSGYYFFLHISIDNSHSGHTAMAVNSVAKFLRHIESTEGAEAAERAWRRVQAGYCLSSALSCPEFGTSTTSGNEWNQELAEVFKAKALTAGNIHCPSLIKIDGQTLSQWLVPKNFASIESQKRFLAALARLKPWVRAGDSANSRLTHELAWGGRMFGSFTAAEVELVRRWIDNLSNHSPQAYLELLDDLPPLPPASKDIRIHYPVFTPEGFESLDFIHAANYDLITPRSDASTILPQLLPLWFTHQCVLEAFMAVPSKTANPTISAMVRVLRTYNGFASVGAGVAGMDEASKTSTVGLIEMGLHMVEQAGLQQPTSLKEVLEWWPCELSVALLHLSMRPNKNRALLLGLASAFSTLHGAVLRSTLLPPADREVLRSIVWTERQAFKLCAEDERRTAPSGLEYQRGLELGEKAVVGICRLINLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBF0</accession>
    <name>A0A1Q5TBF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein mmf2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000004">
        <property type="entry name" value="Translation initiation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF12">
        <property type="entry name" value="TRANSLATION INITIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="111" mass="12069" checksum="7F02B5101DCBDA91" modified="2017-04-12" version="1">MSRQLISSEKFPPKPHNSPATKIPGLVFCAGQTATGDIKQATNLKEVLELSGSSLEQVVKYNVYLADMKDFAAMNEVYIDFLPKPMPSRSCLQAVPPGEGTVIEIECIAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCB9</accession>
    <name>A0A1Q5TCB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sphingoid long-chain base transporter RSB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCB9"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF29">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="31436" checksum="892EE7B2BBA29A7B" modified="2017-04-12" version="1">MSNDTQAYVPCTLQTCPLSDAPIPYQPNLGANAFFLGVFAVALAAQLVLGSRYRTWSYMIGMGGGLVLEIAGYVGRIQLHANPFEFGCFVQYLVCLTIAPAFISAVIYLCFYRIIIIYDRSLSRIKPKAFAVIFMTSDFLCLVLQAAGGAITATTGGASKEAAAMHNTGINMMISGLALQVVSLLIFIGWALDYAWFLSRKGFVPALTTKQSRRWKGLLIALGNATIAILIRSVFRVAELRDGFQSKLAGNEVAFMILEGGMTLVATGFLTIFHPGHCLGVSWKVTPDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCH2</accession>
    <name>A0A1Q5TCH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maltose O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCH2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="241" mass="26550" checksum="B1F6B097F4021537" modified="2017-04-12" version="1">MAELTEREKMLRGELFVSFTPDLIAARNRCKYAYTRYNNAGEVPRRRLVELWKDVIEDKTPLPPRLDDPVADDELFKDEPWIEPPVKADYGFNVIIGKNVFINSNCVMIDSLPITIGSRTLFGPNVSLFAGTHPVDPAVRNGMEGPEMGAPITIGEDCWIGGNVTILPGVTIGKGSTVGAGSVVTKKPSGWILLSDGYHYITFLHGIVFADLVSKQDVPPFHVVAGNPARIIRKIETTMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCX3</accession>
    <name>A0A1Q5TCX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9652</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCX3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCX3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886122" description="Xylanolytic transcriptional activator regulatory domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="55537" checksum="F1F87EDE705BEAC1" modified="2017-04-12" version="1">MANFANAFMLSGIITRMTQALQINLEYNTDLLCQNNDVGPSITARESRRRLMWSCYVLDALVGSGVDQLTLVDEKDMKIQLPCNERNFTQQIACLTETLEPGSWLSFVPEDVEASAIQPNMGIMAYFIRHVSVRKRVLRYIKHLDEAMVPWDPQSEFAMLDADCRTWYESLPPSLQFTRNAMYIRKDSSQLGALCVLHCAHYQTICDLYRLGAPALYKLRAAFEFPPEQRDFLKQLQQVLFDAARSLASIIGETASHGSRMLADSWLPTITYDSSRIMVYHLTQILDPRADETRRITIETIPLLRSNISSLKLMGSLSMISNSLCSAAETMLDRSGIGSDVVAQNSIPDDPYQPHGEEDQTESVPGTPVQSAPDYVLNPLSIFRMARKSIPERHAPEKAATSSAPNSAKPNSTTEVDPPWVGPIQQGVETEASHDPELGLGQASLEELQTLFMSDLGWAWQPADTAVGSGIEAAGLLPWAGGFSTTQAEPWVPAFPFSQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD32</accession>
    <name>A0A1Q5TD32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000674">
        <property type="protein sequence ID" value="OKO98135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD32"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="12693" checksum="D31D3AFC34B554F6" modified="2017-04-12" version="1">MEALARLEREDPKLAFQAARVVGLYRRLWESCMAKHMEGKKLTKANDGLRETQQRLMNEKNRMQSSHDDQLARLHFLDQALESSRLHLTEILKEWNRCSDVLESKPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD97</accession>
    <name>A0A1Q5TD97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD97"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF56">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="34"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="39187" checksum="786F86D0C6D0FC61" modified="2017-04-12" version="1">MGSMKPLSLQQIPFSYASCSIGCGPSDTLPRRLEAIGRAGFKAIELSFPDILDYGEHLLGHPIQPNDYNELTSVAREIRTLCKANGLSVMMLQPFANFEGWPKDSPERKDVFERAAGWIEIMKVVGTDILQVGATDTPADKISIDRSTIVSDLRELGEMLAKHKFRLAYENWCWSTHAPGWKEVWEIVREVNLPNVGLCLDTFQTAGSEWGDPTSPTGLIRNVPENELKKKFAASMKELALTIPADKIYLLQISDAYKVSPPLEDKVVDGLRPQGRWSHDYRPMPYDGGYLPIEDIARAVLQTGFRGWFSMEIFDAGPQGKGKKYEMEPFAKKAMENMQKLLKNCDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDJ1</accession>
    <name>A0A1Q5TDJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDJ1"/>
    <dbReference type="OrthoDB" id="4362635at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="558" mass="60434" checksum="16F80140CD4E911A" modified="2017-04-12" version="1">MSNVQKPNSTVSPMMTPQTMATNGMHDPVSPLSTYDDSEVYLVGRDGIFNGCNSQIEADKETTMVVVGSETDQTTQKLPTQDPGLPLCTYDDMAAKDGVLDGGNSPAEAAEDTTVAEVANSDTGSQKLPTQGDLPLPDEQAACCATDSLDSPGFEDGNGQDGESFARPVIHEAAQGPNDPAAQSENITEQNHKPANDHLGYADYRAEEAVSDSGSRIPPKLDPASSSVKGTQSTKRLTKATIDPDDLPSKDDELSEAQIASLCYQPPRVRQAYTRYFANAGTIRAAYANILMERLPNGELRFPEDVLRSCLPKWKGWKDRLGSSQPGDSAQTGSGPNRKRKGAATPAKRFADEDIEPPKKTKKPNVSKNEKSKEPPPDLDSNYLNLRSSLEPRHQSLRFVSVITPGTALSRGLPPSAISSKPPTAPQAGSSESFPSEASKTPYSQQPKVQNQPSQIAASNINPSAVPNLDEPRVHNHGNCQLLDPNHLSQFAQYLTGQIQQLDLAIVSIAHGAHDQGRRYALRRLRDVLIDLRDLCVDMEIELRSRTVTKSRDNMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDJ5</accession>
    <name>A0A1Q5TDJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_9392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Chromosome</location>
            <location evidence="8">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDJ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDJ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0779">Telomere</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="10">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="11">
        <location>
            <begin position="347"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO98294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="436" mass="48802" checksum="82E91AC27736A862" modified="2017-04-12" version="1">MLTSIQNHGGKVVLLEKDADIILVDHLRKSQTHPPNALSYRYVEQSVRHGKLEDPAPHRVGPAAPRPMGASNIPTKRTRRSYTLQDDQIVFDWLYPWEQSKGAPTHGNRIYKDLAERFPHHTWQSWRTRYLKNLRGKPRPGGGEPRPDLVYGGAEAVPRAGPQSQAPEWPVESPVPAAPPTQHLQPQQPASGPSKQPSPLPSSSRKRGPPSDSTRSPEGTKIAKRRLVEVPEKAPSATRTSPDQPPDAATRPPQTPPREPHCPRPDTSPSNLQPTRPQHPSIPAQPTIPEQTNEIPEKTVDPLFQHLPFFPSSSEPDTEDDEDDDEDEEDSDPDDYPDISSWVNAQAARGAEVATVLDALRYTSMEPVLAKKLLKILKAGDPVPENMRGVWTEEDDRCVESQDARDVERVTTKHGDRLFQARWEYLEMARERGLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDL5</accession>
    <name>A0A1Q5TDL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter G family member 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDL5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="50"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="529" mass="59203" checksum="D135DF0C8A32FE85" modified="2017-04-12" version="1">MGDSMDPNQSIESEMTPENHQNNANPSSECTIAKTSPLSRSDNPDIDGSIQSTASSEPEMFSEGESLNNGALAKTLSSRRSHASGHEGAEWAQIERLISRMFGHERKANSEEEQTRHVGVIWKNLTVKGLGLGAALQPTNGDIFFVLYNPEDDLHYATLTVRDTLLFALKTRTPDKPSRIPGETRKDYQQTFLSAIAKLFWIEHALGTRVGNELIRGISGGEKKRVSIGEAMVTKASTQCWDNSTRGLDASTALEYVQSLRSLTNTAHVSTLVALYQASENLFNLFDKVILIEGGKCAFFGRTEEAKAYFENLGFECPPRWTTPDFLTSVSDPNARRVKPGWEDRIPRTADEFQATYRQSDVFKVTLTDIESFEDEIEAQKHEREAARSKETKKNYTVPFWKQVTILTHRQFLVMFGDRAALAGKWGVLVFQALIVGSLFYNLPNTSSGVFTRGGVMFFILLFNALLALAELTAAFESRPILMKHKSFSFYRPAAYALAQVVVDVPLVFIQVVLFDVIVYLYALRQELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF94</accession>
    <name>A0A1Q5TF94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF94"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="808" mass="90905" checksum="854A462B9C466B1F" modified="2017-04-12" version="1">MASPRRGDRAALARHHQPQSPFARAREPSYEFDLDNSHFPTPSKQSGTRPRPSFRTGTLSGAYRATSRTSMSDDGAGLGLTTSPRQPRNFVSARSPSSDMSNPPEELVDVYRRIEQDGTLADLPLDDWDAPLETRPASRPSRSSPRARDREYEGRAFSEASFVNENSPRRRTSDYARDEQRLRRVTGKDSPVFSKAKVGNRAALTADNLQRREEEEQVHVSEEDDGEPGPSLNLPRTWGTRAGRRSEWLRNVSGSTDSEPQERREEQLPVNNVSHMRAQAEDNVLARYSARSSSRASERGSFPARNALGERTANFHAKDAPQDKKEETSSWDQKAPQGEGVHVPNTPIVVYKNPSFTKATAAKRDSQNLLRKLARTESPKPEQMQTPDQPKLFERRIYDKTPRVTGAWIDTPMTERVAELPQELTKDIVLPSVPAKEPEAPRQEQKPPPNVQPPVTEVKPEPSTVEEPVSEPQPAKRNKSFVIRPKLPKSGLQTVIEDVSSGKETLDLGDDTIESLQAIMDDPTELKTEEEEEAAYEQEVLKRLELANANGQDSVDIDRLNDKLHSLVRNINEVKKGLNSLEEHVIRDAAIVSRQGSPKKAGPQTPDSHSSENCEKCVHDDGRVYAAIPLPRLWKWDPVSQRRQLTKLGWVTFVSLSWYIIECLMWDIYAHPLISEICDGYCMQADAPEFPFVTVTMLWRWSHLEYLLAPVVTISLGFFRLTAQLLGLWDGYVDEPPQLSNIVGEIRVNGTPVSFPWLTSPGQTVAPTQSSIAMPQQPVWTPRNEVPQHEAPIQWSDDQVSMEDDEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFA4</accession>
    <name>A0A1Q5TFA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_8830</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFA4"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="202"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="396"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO98913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="573" mass="63567" checksum="742BE0C01A60260D" modified="2017-04-12" version="1">MSSPDSIQLGDYLFTRLLQLGVNSVFGVPGDYNLRLLDHVEPSGLHWVGNCNELNAAYAADGYARINGLSALVTTFGVGELSAANGIAGAYAERSAVVHIVGTPPRPLQQSRTLMHHTFSDGEYRRFAAMSTHITAAQTNVIDSVTAPDKIDWILQQALIHCRPVYLEIPDDMSETLVSSENLKTPIRVPVTPSASHESQVIARILDRIYSAKKPVIFVDGESRALGILDQIESLIKITNWPTWTTVYGKGLVNEQLPNVYGLYAAAFGDKPAQEYFESADLILTFGPHYSDTNTYFFTTVPKSASAILFKDSTIHVENEIYRDMSSSTVLTHLLQALDSTRLVQATGPPKLEITTTDIKDTDIIAQNNFYRLINPLFNEGDIILTETGTAAYGGRKFKLPPKSRLFGAVTWLSIGFMLPATLGAALAKRELNKPTNTKNQTVLIIGDGSLQMTAQEISVMIKEKLDILIFIINNEGYTIERVIHGRKQAYNDVPFWRHTQALNYFGADEEHVKNSTFQAWTCGELKETLKKEQVHSGSGVRIVEVFMEREDVEGVLLWVLNKQIAEEKQQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG20</accession>
    <name>A0A1Q5TG20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="63211" checksum="3BE5C9E66D62503E" modified="2017-04-12" version="1">MAEHVKTIDFGNDPGALDYLGPSALNKDWQGNIQSVFEHISTFRLSGVWPGYKMNARCGSAKDKKYQNRCSKQGVIAYQWNTKKDASDPNTAPSYDKADAVSNIHFCDQFFNYKKLDEVVDAVKHSDDFKWRYDVSKYKNQAYIILHEFMHATVMTYSQNKNRRIKDLTMYVYEYKRHDYDRGYDRKKVKWDVYQPLACKILARTQRQYIAQDGITMNADNYAQYALAKYVQSKLDGNQYPWLPLADREALEWHPKTSAMFLTSGNGTFGINGGELSADGFTTNDDGSYVANDLDDSDNITLPDEADTDTLAPESDYPTTYNSQMREFSSYVNTPDPTCAKSGSSNPSGRSAFSVSEADAKIRDFCSDKNLYNHVFTPPIDQGCGVTKDGKGKSLGASGSYSINGGKDKLWIGAYFASGACIGMTTWPPKGEGLRDTDLCMDRLRTIMNGCDTSTTDQKYGGSLQEVCLVYQLMAVGSSESDPTGVGSQGDHGDVKCKDTDTSILGDSYKNTCTCWYEKLPDQTDIFGMPKSGGCGSINFMPAWSYLEDPDYRPEDIKPVATITASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGF5</accession>
    <name>A0A1Q5TGF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8687</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGF5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGF5"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="12">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="36647" checksum="E66EA4CC387BB94E" modified="2017-04-12" version="1">MVKSTITLASGKEMPLVGFGLWKVPKETAADTVYNAIKAGYRLFDGAYDYQNEKEAGEGIRRAIADGLVTREEIFITTKLWNNYHRREHALAMAKKQNETWGLGYIDLFLMHFPCALKYIDPAVRQYPAWWMDDAGTVETDKVPIRETWEAMEEIVENGIARSIGVSNFQAQSIYDILSYARHPLSALQIEHHPYLVQGELVKVAQENGIAVTAYSSFGPQSFVELPAVFSEKAKDITLLFDAEPVKVLAAKYNVTPAQVLLRWATQRNIAVIPKSNNQSRLAQNLDVLGFDMTADEIQSIAALDKGLRFNDPGHYLPNHPIRIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJG4</accession>
    <name>A0A1Q5TJG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monoacylglycerol lipase ABHD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJG4"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="137"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="419" mass="46007" checksum="FDC02B3F0D96FA6E" modified="2017-04-12" version="1">MVALQPIFRKAYWALVAGGLVYVLFVTALTFPTVQRFFLYANKVNPAYWQDVNQVEQFGFLKTQVQPFHLVTPDNETLYGWHLMPLHLCREHEKELMENPPSGPAADYTETSAFKILANDLNARVVVSFHGNAAHLGSGQRPATYNALLGLSTPSHPVHVFAIDYRGFGVSTGSPTEEGVITDGVSLLNFLTAGPHKIPTSRIVIMGQSLGTAVTAAVAERFAFGSPDPTAVQPAIKDAEPFAGVILLASFSNLPSLIQSYSVKGLTPPMLSPLIGYPRFQNWIMSHIVDNWDTAARVARLTGVHSSTSDVTRSDYVHKDLDLTIVHALNDIEIPWREGRRVWTAATGEKTKGAPGAVVYQKSEIASPSQIEIWENQITAQDGSQVVKKVRWERVRYGGHNRVASFSVAGLAVLRSFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJT7</accession>
    <name>A0A1Q5TJT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJT7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF15">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="532" mass="58202" checksum="74C9D072B32FEA3D" modified="2017-04-12" version="1">MAAVVHQTPSHDGVTPLKTKGEIDEVRLEAALGHKQELKRNFGLWSLTSLGIVIANSWASTGGTIVAALQNGGPMAVIYGLILVSIFYTAISASLAELSSSMPSAGGVYYWSSVLSRNRGRGAGFFTGYLNACAWLLSASSMSSMLGNEAVAMYLLKYTTVEWHAWHVFIVFQIVNWTCCAIVCFGNRFIPLLNRISLMLSMVGLVITVIVLAVMPKKHASNAQVWTEYHNMTGGWSDGPEVRVPQGIMLQMLTAFTTSFVYLIALFYSIQDLDAVYASNIGFFPTAEIYRQATGSNAGAIGLIAVLFLATFPTLIGTFVTGGRMWWSLARDNATPFASYFAQVHPTLNCPVRATVAMSAMVTCLGCIYVGSTTAFQALMSSFIVLSSLSYFGAIFPHVLSGRRNMVPGPFYMGQKLGMAVNITALMYILVTVVFFCFPLVLPVTVQNMNYTSVIIVGLMAFTAMWWIFRGRREYQGPQYSFEVAERLSAFQAGKEGRRSFIDVATPTPTPCPCPCLDDHIHVGRCDEKRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKJ0</accession>
    <name>A0A1Q5TKJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKJ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="50" mass="5684" checksum="965D3EDD52053612" modified="2017-04-12" version="1">MSGEAFVKRQQTGHPGYFDHRSYWSVANDSRPHDLEVSTQQVDPAVVHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL25</accession>
    <name>A0A1Q5TL25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL25"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL25"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011959641" description="Phospholipid scramblase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="199" mass="22644" checksum="E756C5A9306B5B6E" modified="2017-04-12" version="1">MLRNLLSSLGTLFLLAAVAQAQFQFFEHMFGGNQQQQAQHQASQNVPSDSGRYQKMWAQDEPPQQPDSPAPESQDAINPNYDPSQNTLLSPVYLPEDPNGVLKETHPATKLLANSALVVQRQLEMMNVMIGFEQANKYVIMDAQGNHIGYMAEQEKGMANAMARQWFRTHRSFVTHVFDKHENEVLRVNRASHQYPLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLG9</accession>
    <name>A0A1Q5TLG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLG9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLG9"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="171"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP01047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="37888" checksum="B4B739FAED903663" modified="2017-04-12" version="1">MGAGSPPGPAKPSAIPSHMLNGSSPLQSSTAAGSGTRVRDNRERESLNSSIRSSFAPRVPAEFENIAAGSHSVGEPTASTAATAATAATDAGAAQTALSLRGRISLNEPPRDPRDEGAPLTPPATSSRPASPYTMNPPVDFDGLSWPCPGTRQRLESTPEENEERIKKLAGAVRTILECVGEDPEREGLRETPERYAKAMLYFTKGYEENVRDLINGAVFHEDHDELVIVKDIDVFSLCEHHMVPFTGKMHIGYIPDRRVLGLSKLARLAEMFSRRLQVQERLTKQVALAISEVLKPRGVGVVMESSHLCMVMRGVQKVGSTTTTSCMLGCMRSSAKTREEFLTLLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP40</accession>
    <name>A0A1Q5TP40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_7211</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TP40"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012186045" description="Vacuolar protein sorting/targeting protein 10" evidence="20">
        <location>
            <begin position="24"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1377"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1427"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="49"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="722"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKP01981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1507" mass="168886" checksum="95C86EFA98035F17" modified="2017-04-12" version="1">MIPRWLLLVVGLLLAWSAQPATAKGDKPKLSTETLDHAPYDLFYFKGSETVLYRDFKKHTAHVSFDGGSKWEVIKGPDGKMEGAAAVIWPHPYDSKRAYILGEKGQHWVTTDRAETWKSFEIEARPMMTERGTPPLAFNGWNPEKVIFMGLDCSGILGCMPKAWYTTDDFKTWNPLQELFYSCMWAAGTPEFGHDLDLSEKLGDRILCVVPGLKGTMHSERLIFSDDYFQDSIDGTEVNLDRGRPVTGSQIIARSVKKYLVVGLQSQGTTEQALYISDDSKEWHRAEFRGHRIEQDAYTVLESTNYSIQVDVQTTWHKNSVGVLFSSNSNGTYFTPNIEHTNRDANGFVDFEKVADIQGIVIVNTVKNWEEVEESDKADKKLVSGISFDDGRTFQPLKADGDNLHLHSMTSYDSMQELPIGRMFSSPAPGIVMGVGNTGDHLKKYSDGDLYVSDDAGLTWRRALKGPHHFKFGDQGGVIVAISDDKTDKVRYSLNHGKDWEDPIKLEHKIKPRYITTTPEATSLKFLIVGESEKEGYIIYTIDFDGLHERKCTKDDLEHWWALLDEDRKPKCLMGHKQKFTRRKADAECFIMEDKLDPPIFEPCDCTKEDFECDYNFKRNDENECVPAVPLTPPAGKCKEKGDKYKGPSGWRLIPGNTCRRTDGKNLDDEIERSCDDTAGSPGSGIGSGDGKVHAGNAHEFAGARLDYFYLERQTSSAGDDETIFLLSGKNEVFVTHDHAKTWDQPKELKGEQIVGMVQHPYYSDGAYFLTSGNTAYSTINRGDTFKKFKLPTSLANLDQEGPNPLAFHEKYMDWMIWMGNDDCKGSDCVPDAYFSKNRGADWEGPDLRGVGQCVFANHHGREDSENLVICEQYEKESKKYNRQLVSSDSKDNWFGDRKVINDNIAHFVTMNDFIVVATFPTEKHKYLNVSTSMDGRVFAQANFPINVDVQQYTVLPGSTDALFLFVEISAEKGHSYGQLVKSNSNGTYFVSSLPAVNVDDRGYVDFEKIANLEGVALANIVGNVDDVKNKGSSKKLRSVITHNDGGQWALLPPPTRDVEGKKFGCSVTEGKGTESCALHLHSYTERRDWRDTFYSGSAIGVLVGVGNVGEYLTSADSEDIGTFLSNDGGITWNQVKKGRYMFEFGDAGSVIVLVRELEPTKSVFYSLDEGKTWAEFQFAETDVTVLDISTVPSDTSKSFVLWVREPKSDGRFATIPVDFSGIWDRECAPPDGKEPSDDYYLWTPKHPMQDDNCLFGHVEQYHRKRPDKQCWVNWRDPHVHRVDSSNCTCTRADFECDYNYEIQSDGSCGLIPGFLPPDHSLTCKDDPNQIEYWAPTGYRRLPQTTCQGGHEFDKLQPHPCPNKEKEFESKHGISGIGLFFAIVTPIAAAAAFGYFVYTHWDGKFGQIRLGESGASSGQGLFARDSLLVAIPVIIIAGAVAMAQALPMLAVSLWRSVSGFVRARSRGYQRPYATRASFAARRGDYTHVVDDEDELLGADDLDEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1J1</accession>
    <name>A0A1Q5U1J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1J1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1J1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="22601" checksum="41542F914E2E390C" modified="2017-04-12" version="1">MLGSGEVQMPKRDSLPVSGSTNTSISTHRQKLLDKANGSLEALRAMTGSVWGASLVAMRKVYQAVVVPQMLYGISAWYCPAARFMPTWEMKRTVNEFTNIQRRAAILISGAFNPLDSSGTSKSSQSPRRAKETIRQDDLATAQGVKMLGRGNAKTTANREVVEEYIQHQQQTPPIENEAGEIPGMEVQRKRLANVRAWRAFWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2J6</accession>
    <name>A0A1Q5U2J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydroxyquinol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2J6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2J6"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="112"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP06718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="330" mass="37305" checksum="FB20B96140F28C35" modified="2017-04-12" version="1">MDSSNKRIPLLKDLTIDNITDNVNLVNSKNPSPRFKFLLERLVVHLHDFARETRLSQNEWLEAILFLTATGQICSDVRQEFILLSDILGLSLLVDSIDHPKPAGSTEGTVLGPFHTHDAEQLENGAIMSHDQNGEPLFVLCTVKDTQGNPVSDVKIDIWETDSSGMYDVQHLEREKPDGRCILTSDEEGKFWFKGIVPVPYPIPHDGPVGMLLSKLNRHPMRPSHMHFMFEKEGWDKLITALYLRGDPYETSDAVFGVKEPLIVDLGRVDKDLARKYPGIHEGTRLMTYDFVLVTDKETVQLRDRNSVEALKKLNMSVKIVDGLPVPQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3D9</accession>
    <name>A0A1Q5U3D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3D9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3D9"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="351" mass="38752" checksum="C7BE80027BAAA410" modified="2017-04-12" version="1">MESEAYRQASRAPLLQGVMWTMAIVPLVFVLMRLYVRVVMKRVFGWDDFIIIVATGCLIAYAAVCHVAATIGLGRHLTVVLEENPNHVIDVALLCDIGEALAIMACTLGKTSFAVTLLRIVVHRWMIIVLWFVIVTMNLVNVLAALFIFVQCKDPRHLWNSAIPSECWPADVFTHFSLFVGAYSGAQDFVLALLPWTLVWNLQMKKKEKTGIAFAMSLGVFAGAASIVKTTYLVALSEKADFTWELAPLLYWAAVEDGLAITAAAISTLKPLLARVFPGSSINNNYNMISYSTAPNRKVFDNSQGETRTDIGHSSIHERGSQTAILAPLSPKRDETINLTTEVSVTYNRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4J5</accession>
    <name>A0A1Q5U4J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4J5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4J5"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000652">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="60"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126287" checksum="62EDBC40C4AD8054" modified="2017-04-12" version="1">MEALSPRTTNQMIKPKAPMDRKMGDKPATTTAPKSSSASKNHADPPPSVVTEPEEDAERYSIGGFLGKGGFAVCYEGTLARNGRVFAMKVVKSQMPQKKMEEKFRTELQIHSKMRHPFIVQFYRAFAFEQSTYVVLELCPNGSVMDMVRKRRCLSLPEVRRFMIQLCAGVKYLHKRFVAHRDLKMGNLFLDRNMNIKIGDFGLAAMILSDKDAKRRNTLCGTPNYIAPEVLDKSKGGHTQKVDIWSLGVICFAMLTGYPPFQSKTQEEIYKKVRNLTYVWPKESENSNFIPDEAKDLVSACLNLVDEERPDPDDIVEHPFFNMYDGCIPRQLDPACRFNKPIWLKDQSPRGDSMVKGYGLDSDEKLRAYVYQVDDPSQRYHSCKAAFYSLCGVGRKPDGTARKSVGRNCSKSAYSECETEDARGLRPVVPLPMDFVYRWPHEIEGDWCLMESSRKTIRTEESAMDSSTLSRRSVSVRTHAVAATRTNAALAAAQQRRMEGQNHAATLRQQARPGMASVRKAPVVSEFAESITNSYRNPKESEPTPLSSAEVPSGGLAERPIRTRRMVSASNAPTLREIVAPQLAKSTSMPSGLTIGKTRSQSRRMELANQGPQPPIPTSDAKLSAVVEERRIMSRQASLRSVSRPDLKISAERAERPKLSPTESAFSSTQHTKSTTQSQGLSRTDSKSNKARSSLGLSPIFHPDDVCQDLPGTSLSDVNTNLRLMLANLVTQGPTRRRVGSRKQPHAYVIKWVDYTNRYGIGYVLDDGSVGCVFKGENGQPATSVVVRDGERHIRRKARSVDTPEEKGIPYSEADQLVPRTGAPVEFYENRDDSLLGCRGIRRALIHPSLFDAKNSKVMKLRVNSGSESERSDVEKVKRVKLVDQFGKYMIGSLGRHGDEGIMDETPAQSSGQFIKFYQRLGNVGIWGFGDGSFQFNFPDHTKLVLAPGRTRSSSPWIDFYHLSPTAARFFTQKGKMHSSGFDTRAVASDEAATFLSIANGESINSVEDRIKDILEANSFLQKISFIRDVLKVWIKYGRLGGRPSPSRAASGDDSIPPEMFWQGTQDRSSTGSHGTKFVWVTVGAPDGDGAYRSIMLKDSDREKFEKRTGMDYDKEMDMLKERLRVMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4Q8</accession>
    <name>A0A1Q5U4Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4Q8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="99" mass="11349" checksum="5C2525DF96A97AAD" modified="2017-04-12" version="1">MIRVACPKIMPLTPAVPKKNTTGDPIHRRDIRINESRTSFTRSPCNPQLSPIFGPLRSVFGRDVNLTILGAHYPEPDRSQQHADRIRVTRVRVYRMRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U6W8</accession>
    <name>A0A1Q5U6W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U6W8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U6W8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011982011" evidence="1">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="194" mass="21705" checksum="1EE011EDD7AD13E7" modified="2017-04-12" version="1">MARWLRRMFWAWYLRVFAGIVSIRQRQNGTTRFGRSSSGTTDGMAGMKDHIISAPLYDFSVPTFVKGLKVLAHMLEMGADHARENGIPIDDIAGWKLAEDMLPLSFQVQTASNTAKNSLPRVAGTEAVPMEDNERTVAELQKRITKIVELLKAVEAVKFAGKETDQVLMKAGPKELEFTAKTYITCFALLLFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U714</accession>
    <name>A0A1Q5U714_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U714"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U714"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="429" mass="46566" checksum="10F9C371160F103E" modified="2017-04-12" version="1">MSLNSLPAEILQQIGEYITSLSTLNAISRANCRFHLIFDPLLYAQDAQRTRGQSASAGGGAAAVRWAAQYGLMRTMQKSLEGGSEIPSRGPWMHVVHEPAGRTVYGVRVDWRFRDPVPPPHPLCLAAQGGHVDIIEFLLDVKGCDVNVTDQRGLSLLEIAVVHGHVQLAEGLLRRGANQLSGRQLTGSLAKVVSSPMQLAVLLGKLDMMRLLWDYGVRVNIGGPHRNSTGPLELAARIGDVELVELFLSAGARPRYAVSDTECALVQAVMRRDEKIASLVISDSTCMQKTIALTLAASQEDRQLARFLLARGTHPDFDDLEYSDVHCPKGYADTWHFASPLAHTVNEGHAHLVQLLVESGADVNVPFEGFEKSKSSRQTGSVLQLAMELGNRDIVSFLRENGAQEEWRNGYAGAPSGGSKSDPNASPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U803</accession>
    <name>A0A1Q5U803_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U803"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U803"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="27776" checksum="9B6D9C36892BC47B" modified="2017-04-12" version="1">MASQLHELSERPPRYITKEEAALINSENIDDLQIYRASLWAREKIEIIPLARELLAVEYELLSIDQRLAAKIAKYGPRTTLAGQKRSQHWCKEREWYAKMAAIPDGPFLRGMDLWRSTPKWYMHPVLVQDCAGRGGCCGRKCGCCLRRHDSSVTKLTAGHCTLECSCCEQVRDFELTSSQKKDMKELFDLRVDTWYSYRILLASSQGLTFEDLVEPLDLVEEGSDTGTEATEVTEGGYVSVSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9R7</accession>
    <name>A0A1Q5U9R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain-containing YSC84-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9R7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9R7"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="144"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="726" mass="78588" checksum="EEEA3D145494F4B2" modified="2017-04-12" version="1">MSAWQKTKRYSKKGFDKAWDTVDKLGAPVNRLSNKLGAEAFWPMSIDKESDKAARILRSFCKDGFYTPESESTTDENGKINRPKGKQRVIKKIPSKVIKNAKGIAIFTTMRTGLWISGSGGSGVLLARIPETGEWSPPSGIMLHTAGIGFLAGVDIYDCVVVINTYEALDAFKKVRCTLGGEVSAAAGPVGMGGVLDSEVHKRQSPIWTYMKSKGLYAGVAVDGTIIIERTDENEKFYGERISVTDILAGKARHPPDSIKTLLQTIKAAQGDVDVDESLVAPSGETPGDLDVSGNDHLFGVPDMDDPDPYGVKALEAEGMFIREAGSKVRPSHEAFEFRPKPGSPVYATFSRRSLDSSPRNSWRASVQSYTSVDRGTQTEDASLTAPTSVSRASSLSAKESTNGPSAKPWEEDEQAGWDTVPIHGGEEKEEGTKEGTTDARGLNGYAETEKNQAAESDDEFEVHEVSNATITRPESPKEEQVDAAESRRMSPTFTRAKLVTINKRPTPPALPPRHPRHTWGSGSSRESTSPTALSHTSRSTEETETAPEATESTEKPTESSALPSNVKKLQTSTAVPAVVDDVDFDESDSELPADKDEFLSAHSDNEDDNERHALAEGLAALKAEGIKADEAKTEPKEPIAENEAPKAETKTENKEVEGAEDVLSQLEEKFPSPEVESPTKKVDVQKTSSNNKFGSLEVDEESDDTIETPADQKPLTSDISPKTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB64</accession>
    <name>A0A1Q5UB64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_4978</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB64"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="36"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="152"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="628"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP09707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="712" mass="77622" checksum="55AC2118899C7F6B" modified="2017-04-12" version="1">MTLSSLLRITPRLVPTAARRTTRAASSVSGTQGNKTLDSILIANRGEIALRVGRTAAEHGIRVTTLYTDPDSRAQHALSTPFAFNLGSVSAYLDGDRIIEIAKKEGCRGIHPGYGFLSENSAFARKCTEAGIVFIGPPWKAIEDMGDKSRSKEIMIAAGVPCVPGYHGHNQDPAFLEAEADKITYPVLIKAIKGGGGKGMRIASSKAEFQAQLESAKSEAMNSFGDDQVLVEKYITTPRHIEVQVFADKHGNSVALGERDCSIQRRHQKILEESPAPHLPDATRKDIWAKARSAALAVGYEGAGTVEFIFDNDSGEFYFMEMNTRLQVEHPVTEMVTGQDLVHWQIMVAEGAPLPMTQEEVEERIARSGHGIEARIYAENPDQGFIPDSGRLLHVRTPATTEDVRIDAGFVEGDDVSAHYDPMISKLIVRGETREEAIRKLGAALEQYEVAGPVTNIEFLKTICRSPDFIAGAVETGYIEKHRDELFAPKTIEDEVLAQVALACLHRDVHSGGAAPSTGLAGTTIGFAPSYQQRQLSFTSSTGPNTEGTTFTVRVQQTADQTFNVEIGSRVFSQVTSTMDPASRVVTSFFGHTRLDTTVVQDAETDTIIAFQRGIQYRLGVPRAKWMEKALGMKDVANSVLAPMPCKVLRVEVQAGDVVEKDQPLVVIESMKMETVIRSPQRGTIARVVHQQGDQCKSGTPLVEFAEEPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBN5</accession>
    <name>A0A1Q5UBN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000437">
        <property type="protein sequence ID" value="OKP09892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBN5"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33140" checksum="22A6D7AE4A433625" modified="2017-04-12" version="1">MTPKFELRVLERESATLDTIIPILKHNGGVVIRNFMSPEILGAVIEEVKPHFGDHLGERGEIFAKQSQVVSGLAAKSPSFVENIICDPLYGSICDYLLTSRFTSWYGSEQVTFDAQPQLNAAVSIRNQPGGEAQKLHRDDMGHHNHLPRIAPEEYAIGRDTGVGIFVAATHTSKENGATRFIPGSHLWGPENAPDESLTVPVELNPGDVFFMLASCYHGGSANTTMSEQRMIFSAFMTKGFLRQEENQYLTVPKEKLQGLSVEACRRLGFAPSEPFLGWVDLNDPRTALGLPTELKAGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBN6</accession>
    <name>A0A1Q5UBN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_4801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="11">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="12">
        <location>
            <begin position="229"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP09877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52227" checksum="9534C77458EAB356" modified="2017-04-12" version="1">MAKENQAQSFKVSGSFKAPLSGNSYEKVRPLHKVAGYTTIFSALIHGLISVIAYHEHGHIDKFKHPENVAGLIAGFCLLIMGISSMRWFVRRNYEGLHRTDFAESTIKINIFIACLWFTDRLFRLAKTCWNFVGNYAILTPMADGAVRVKLRRSLACHPGSHAFLWIPSIRLLETHPFTLISNSPSEFLIREYDGFTSSLFKAARENPGKAWRCSVDGGYGQVPDFKRFDRVVLVAGGSGATFTFSIASSIVRERKARGTTVQIDFIWVVRYADCLNWFAEELKELRETPFVNLIIYVTRNNVISEDASIPEMIEANGSENIASSVIGDIEKGQKENDKEAFPAPEFRKGRPDIPYLLTECLSRCSIEDRVGVGACGPSDLLDYVREGVSRKAYDHGPSIAFHYEVNPSSSSQHSVRLFTDSRLGLPLVKWKFTNRDQNIPLGSFRVCGLVLRAEVHATVTGTAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC53</accession>
    <name>A0A1Q5UC53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cellobiose dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_4508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC53"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC53"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012999421" description="Cellobiose dehydrogenase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="224"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP10043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="41034" checksum="C380012197EE5827" modified="2017-04-12" version="1">MAVLYLCWLAWAASCLAQLQSFHPIGHDDLTYSINIPQSTAQSGSGSIYFQLNSTKQVRWFALGQGTRMVGANIFVVYPNGNNNITVSPRLGMGEIQPLFNSDAQVSLLDGSSVSNGAVTANIRCDSCIKWTGGSADVTSSSSSWIWAVKYGSPLDSSDVSAELTQHDDSGAVTVDLVKATGGSSDNPFFDSSKSTSSSPVTPTKVTTATAQNPLAVFNKKRTAHAVLMIIAFVIMFPFFALTLHIFPSSKTASVHGLLQLLTLVVALVGLGLGVSMAQDINLLTNHHPIIGMVVVAGLTAFQPIMGLLQHRYYRKSGGKGIFGYVHRWFGRVMIVLGIINGGLGFQLARGPKGAIIAYSVVAGIVGVFYCAVIVWVQMGPKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCD1</accession>
    <name>A0A1Q5UCD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCD1"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="35436" checksum="8026B4D2E41B47D3" modified="2017-04-12" version="1">MSSKASGAADSLLHPDSSKTPVRIEIFAAFAAIAWYNAIELIILCFVSFKRRRGCYFWSLLVASSCIVPHCLGYVLLFFPTGVSPYICVTLVVFSWYGMVTGQSMVLWSRLHLVLQNTKVLYGVLWMIIVDAILFHVPTTALLYGTVAAPISVWSRGYSTMEHIQLVGFCIQELIISGIYVWETVKLLRLRPQGRPNGILHQLLTINIIILLLDIAIVVIEYVGYYAVQVMFKPVAYSIKLKLEYAILGKLVAIAQGAQTYNDDELPSSTREINSFPSSQETPPRPGFAQHPRRMYNFPWFWENSHQSICTSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCG0</accession>
    <name>A0A1Q5UCG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000381">
        <property type="protein sequence ID" value="OKP10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCG0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="146"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="23331" checksum="2B13A6CEE3599BAC" modified="2017-04-12" version="1" fragment="single">MGDLRLPDEPTQQAGLDGDFPRPAHAYTFPAEGTGSLKAGRTSLKTSINCETDVSIAQAEGEITQDAEITQDAEIQRRRHGDFDGILGSAGEVVQSSGVGDGKDLDGPKFSFGSQIRATLFNSWINVLLVAAPVGIALHATKANPIVIFVTNFIAIIPLAAMLSYATEEIAMRYGELIGGLLNASFGNAVELIVAILALVKHKVVIVQTSLIGSMLSNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCG4</accession>
    <name>A0A1Q5UCG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000380">
        <property type="protein sequence ID" value="OKP10167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="179" mass="19735" checksum="DEC5DB6BE230A25C" modified="2017-04-12" version="1">MSLLDLDVSVAKNMFNVNVFAVVTVTQAFAPPEIASKGTFIKHRMRLEFSPWGVRAILVTTGAIRTKFFDNLPSAPCLPENSLYYPAKDVIEPALAGTEVEKNVMDVTYYADVVVNNALRSSPKQHLWSGGGALITWLASTFGWSTVWDTLLPSVAHLPDVNNKIRAAEKAEQDRQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD83</accession>
    <name>A0A1Q5UD83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1068</name>
        <name evidence="5" type="ORF">PENSUB_12543</name>
        <name evidence="6" type="ORF">PENSUB_4115</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000734">
        <property type="protein sequence ID" value="OKO92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000323">
        <property type="protein sequence ID" value="OKP10458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000152">
        <property type="protein sequence ID" value="OKP13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD83"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD83"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="320" mass="35921" checksum="0556851CEDC2F153" modified="2017-04-12" version="1">MPFPEFDSKGMEYRFLGNTGLLVSAIGFGSWYTVGGQVKDNSVIEKCMEEAWNCGINFFDTSESYAEGQAEIEMGNAIKKLGWSRKDFVISTKIFEGGVSSDPTISKGSTWNKHGPNDIGLPRKKIMESIRGSLERLQLDYVDIVYAHRPDYCTPMLEVVRAFSDLVTQGKANYWGTSEWSAFEISEALAAAREHHLIAPVVEQPQYSIISRYRFEKEYALLFYKYNYGSTVSYSSCTCAQLALAWILKNDNVSSVLTGASRPSQISENVKAVQVAHNVTPEIMVQIDELFKNKPTRALDPFGRWMGGSSKKTDMTLDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDG3</accession>
    <name>A0A1Q5UDG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argonaute-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDG3"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="546" mass="61862" checksum="D70DE0FC11429439" modified="2017-04-12" version="1">MDPDTAVPPTTISGDLPIRTGKPMEPSISADAENTPSQDHSWPSKPTTIETAPDDQLPKSKSQVGIPQTKLDDEVAIRAGEIMASAGPKAKRRKPKSKRGLGKPTGFEEYYADGPMTPEEHEESHQLYGPSYSFEQRIQEALTRYQWKRRMENDRRAIFFKYLQYGGVDASQNYGTGVSLKELEQMSNDEARQARSQTMIQRDREELEVNFEAVARGFLSSFYANHYNPESEESIKVATGTIRNLLTYLLYHDVCPEYKDDIHKARQICDIASVELWKNVQLIQQGPGTFNQSCSMLFGGRYAESGKDTCDWMPAQCWPGNLTPDAARKVVKFAIAGTGTHEQAVRFQVLAAQGKLSAKQIPDIDGFEVISISQPENDIREFYHEYAPDLPVVGKIIAKSFRNPAKPEIDMSPEERKAWQEGKAPKYDFVFFVEENLLQHCYPGLRIASSIWEINCGVYYFDEIISAYPSFHLVLANDLMLRWKTPKEIVEEKQKHLEMQDEGWQQPEVEDDPEGDGKLDGVGEAIKDAFEISRRLREQAEEVGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDL2</accession>
    <name>A0A1Q5UDL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3879</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDL2"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000086">
        <property type="entry name" value="Probable porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="14">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP10576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="339" mass="36723" checksum="CF45D95986CF49C4" modified="2017-04-12" version="1">MAAPAPATKTSFTIGTRKSKLALEQTELVAAALKKTHPDYEFKIFSKETAGDLNTKIALRDFTTKNLWTEELEELMIDGQVDFIVHSLKDVPTVLPATCTLGPMMPREDSRDVLVVKQGLSYKSLAEIPAGSVVGTSSIRRTAQLARKYPHLKVLDVRGNIGTRLAKLDAEDSPYTCIILAAAGLLRLDLGDRITQYLDSKSSGMLYAVGQGALGIEIRKEDTFLKDMLSKIGHQETTYACLAERSLLRTLEGGCSAPLGVETEWVQTAEGSKKLRMRSVVVSVDGQQCAHVEVDGDVDSAEGAEAFGVTVAKALVEDGAGVILEEIQRNKVVKENVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDT3</accession>
    <name>A0A1Q5UDT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein zas1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3915</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDT3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDT3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001281">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001719">
        <property type="entry name" value="C2H2 type zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1076" mass="119729" checksum="54D07F71A38352AA" modified="2017-04-12" version="1">MLSETETDHADAGDLTADVTSPARDSVDREQDPNHHASGDRAEQGAGAGQVQCTVCSSTFRRPEHLKRHLRSHTKEKPFECAQCGRHFSRTDTLHRHELSHHTPGGEGGKDRPHRITVKTFRACFSCATARVRCSGGMPCGRCDTRSLECQYPTERRSKARLRNGSLKGPSTLHLETLEVEPQSPRNQSPRPSGNNAAATHMNNDIPSHQLGQFSINGMNNTPTSPKASIHPFPSPSNPRSEKNSSDGRGSVAGPSNPQLYTPSANPAADAPTLPPSVYPNGEYNPGYGELPDSGMLPVGTTANLVHEMRDVETGMAGPGVGMDIDMTGNPEMALGFDPSIFDPSMLSTINWLPNEFFAGPSSDQSQSSRAPQHFPQGALPDNYAARFTWQPSVINADNISPSVPENNTHTPSGPLSLGTDMGSPRRYSHVGSEASPHAESVDSAKRSADFYVDGGGARLPRYRKKQTPWSTSSIDLPATTGQAFSENNTRRFGFPGVQEVYMENIPEEVLHSIRPLEAATYDELYRNFLLLCRNDNPFFEMFETENFPRPEECTRYLACYLDSFQAVYPIFHVSTFDVNQCHWVLALAILAIGCHSSSIHDADQCTAAFHEMLRRAIHVEKAKRHAGPTPLGLLQAMLLNCIGLFHSGIEKDKLSALSAFKELVRLVEDKKLLAASKPLKESGRISGEVLWQKWIDDETRKRTGYCVWLLDCTLAYYLDERPLLSLDDGQAALPAHEKLWQSNSMEDWKQLWDQSSMNESLYDSVHILYIEKRLVSGIGEFSHILLIHALYHRMWEVGDYFRRPLSFWNPTAKKQSRETAIPTGSVWLPGIPSYSKWRNSACDCLDILHWTANSTVAKAAGLEHPTVLHLHVARLVLLAPFREIRALATSLVTDKLRWSKRHQAIEWQYIWRWIKHDQYKARLSIIHAGVTLWHVRRYSTNAFHEPVAAFLAVLTLWAYGSCHGTSQDSSPQNQASRNEPLQEPSFIHLDRPCDDELVQLFVREGHSMRGNVTGVGDICAPEGPERILRVGCETLSGLSAWGQSKRFVSILTRLADLVSRGSEGEQSRNANTEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UED8</accession>
    <name>A0A1Q5UED8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UED8"/>
    <dbReference type="OrthoDB" id="4367615at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="41241" checksum="E277BD50E72093BC" modified="2017-04-12" version="1">MAGSPAREASERQSRKRRGSHITPDKKKKAISSSQSPSRAENSTTKPVPMAPPVVKATTSTAPSTGKGPSNTKDKTKGLSGDEITKPKSTKPDLIAKASKAKSGKLPGKEKNLEDGERATTKKDDSKEKKPDLKGNKLEKKDDSKDKSIKDPEIPKVNQGVKLPDLVKPAPSDSESSSEEDYEDSEDSDSMDDSADSDDSDESSETSESELAASDIDNFDEDLYNFFALQYTDLRDLSPERLEMEKAKTLRRVQAFVDNTKDKHYHDIKLETLIGPGNYIRWVVGLEVLLRMHQVWGVVGDLDVPLDKDHEMYPWYDHMVNTAVSLIYAHVSKKIRSHPCFIRGVMQRSPGAMMQHIWAHFGSPDAAQYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEN4</accession>
    <name>A0A1Q5UEN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEN4"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="247"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141508" checksum="A7449BE392C1532C" modified="2017-04-12" version="1">MSVMRHGGSGFLQRRLTKLYTDTKTSCESVTTASKALDDPELVALHQSFQKQRDRLLSWGLDWSDASAAQPNDIDESLTAAGFSDVVESVMSTIQDLLNDAERVQHIDTPMPSKERKVDTKDTLGSRPLKTQWTDDDISRSKTILSDLTACIDTLYDLSTSRRTMASSMSSSKHSMAGRRSKTHPLPTRDISYASFSDSKEKIQSPQQIYEPFTYSPSTPKHDYSHQSLVIERSALQLYGATHDNSPPPYEPIAASSNSRVVGRLKTAACPLLVGSVKDSHVSVLVEFMPMIVDSQASSKSSRLQKLQNSLDQLLQNARVGHLGLLRFLGYCVDDPNARYAFLYQMPVDYFPFLQNPSDLLKELKPIPLVALLPSAEDYREKRMPNLETRFRLAYDLMMSVLHLRSQNAVHGNINSSNIIFFPGRTDASNDERGLAPDMRRPYLTSPARFSGDGHTPEPLSTAMYRHPDDKRSVEDEAAWAYDLYSLGLVLLEIGLWAPIGRLWKMKYDRSWFKHRVEDLYVKKLGPKCGNAYLQVVQLCLDAPNFHLSTQPMTDLNLRVPQIYHYPVLDLSDPDGTFSFSMNFLYTICKVLWSCTRIDIFSAPPAEELDDSLPLALVPTPEPTPAEEKANPYTLSHEPMNLDKQLPSTPNNQWGIQPEERSLEKPAKKRTVKRLPHLDIPDEHLQEWNFQMMPRLSRLLQKILKESDESAGATLMMTGESPETAKTTICVTCGSVKKVRSALKKHFPLDRDDWDLIVLRGDIERSKVPRTKRRRPAKTRPNGSNEVPFRQRELNPCYQQRPLCGASIGAFQNEEHLPPVSYGGAVLVDGQPYGLTVHHMLEAPSDDEGPGDDELEAPLRSAGNWPRDTSRDASSVSNQDFMYSWREDEPSEINLDLEISDQEDDDASFSQGADGGLDEYWLSEDESSDEESIEGADNDDDDDAASVGDTAGVEPGEEPRLLVTQPAIDDVHDDFFPTPEDRDDEHLASHSLGYIHASSGQRRWTRKGMKHEIDWALIKVDENRMDPRNIVVDTTTTLPGRPGFGRGQPQPIFLNQVARMEELGGLLVHCCGRTSGLQTGQISKAMTLVKLHGRHSFSTSFCVNGNFGAPGDSGAWVFDRSTGRVCGHVLAWSARSNTTYISPMEVTFEDIARTLNASLVSLPGDPSRGMGYAGLTYPHPHPGGYSYQTQQLPGDFNRLAVGGIPQGPPAIPPHPLAHPRPHHPGAFMRPPPPPPPPPRPGSQEAHVFRAVSPIPPSLLTGPRNIERQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF15</accession>
    <name>A0A1Q5UF15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000307">
        <property type="protein sequence ID" value="OKP11070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF15"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF15"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="131" mass="14922" checksum="C3C7D73CF6956FE6" modified="2017-04-12" version="1">MVAAKKHVPIVKKHTNRFFRHQSDRFMRVGASWRKPKGIDNCVRRRFKGVIRMPKIGYGSNKKTRHMMPSGHKAFLVHNPKDVELLLMHNRTYAAEIAHAVSSRKRVEIVAKAKALGVKVTNAKGRVTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFQ7</accession>
    <name>A0A1Q5UFQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000290">
        <property type="protein sequence ID" value="OKP11304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFQ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="488" mass="55157" checksum="642DE374CFB7BDE3" modified="2017-04-12" version="1" fragment="single">IGAFKSLSTDSPVLDCPEKLYRLRVLHGLGEQELKLKDEIMDQHVFCQALREADGIRFAPEKPLTRGWLGYRMKRGGEITGFAEVAKPYCLRYGAAKAFNDSPDVSNELQNVMLQHASIDTFVRHYSVGIHVDAQAIVRGLPAEKQLMRFACSMSRSIDPRRPYRLEDSSCINDIPRVRALEDTKQARKRIRDVKMRTYEDAEAAFQGEFGDDPQSATLSKTARKRRKAQEKSLKKLRQKFDHADEQYDRAVKQLRNEKRRQKHRLIRENLERYKNEQPVIDSERQLSGKVVDEEVMGALQRTGYMTPQHMTLIDSILTMPGTTVTKEYERRIAAINAVIAVCDAEEGAPSRPGASQKRSVDAVDTPPASPLPKRQKSTPSDESDDRFSQAIASVCVKSREERPTICFICLGKAKLPESKRLQTYKNPGSLSRHFVNQHIKPFPNDMHCECNICGEKLLSKSGLLNHAQRVHGIVSCLPLPALGLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFV5</accession>
    <name>A0A1Q5UFV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000284">
        <property type="protein sequence ID" value="OKP11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFV5"/>
    <dbReference type="OrthoDB" id="4367253at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="16831" checksum="17170F981D635FB1" modified="2017-04-12" version="1">MQFNLATPKRDSHCHPLQTRVQVVVNFLRQRLLVAMMAKKVRKDAKLALQEALECTLDRSTQPGSPLCLDDDESTQAVELFDDEEIEIQISFDFDLQSSLTRFSCWTGALSKDFGPDMSVRYPRPVFEYFSKYIWFVIVSLAWSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG36</accession>
    <name>A0A1Q5UG36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG36"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG36"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="418" mass="45587" checksum="CC71878593B0CC07" modified="2017-04-12" version="1">MAPPKVFSLEGKGLKLDTAEDIEAHIKPLVESTDYTEIRFGGNTLGVGASERLATVLATQKSLEVAELADIFTSRLLSEIPPALKSLLDALLEIPSVHTVNLSDNAFGLNTQAPLVDFLSRHVPLRHLILNNNGLGPAAGTLIADALSKLAERKEEARKEGKEVAMLESIVCGRNRLENGSMEAWARAYEKHAAGMKSVKMTQNGIRQEGTSYLLKNGLRHCSALEVLDLQDNTFTIMGSTALADVLAGWPALIELGVGDCLLSSRGTVKVAKALAANKNPKIQTLRMQYNEIKADGVKALTHAAKTALPSLRRVELNGNIFSEEDPNIADLRELLEARQEEHGTDDDAEDTWGVDELDELEEEGSEEEEEEEEEYEEVQAKAEKDLEDADRAEQEKVAQKSDKEVDELAEALGKTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGP7</accession>
    <name>A0A1Q5UGP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="408" mass="45427" checksum="8E9A03DDF35ECE94" modified="2017-04-12" version="1">MAEVPSSFGTPEALSPLICRTESDPRPVVVMTCGIAGSGKSSISKWIQSNHPSFHRLSIDSYIYSHHGLYGVDYPKEKYNDYQEEAAAALRSELAQLVQQGSRDAILDFAFAFQETRDEWKDLIEESGGRWVLVYLDVDADELRRRVKARNQLAVKDGDSAFLVTVEILESFIAGFERPVGEGERVEDKRVEDIKCTATYLISRKDVNSEKIGVLGICASGGYAPFAAQTDLRIKAVATSAAVCVGTMARRGFDQDTSNMDILKTQLEAAGKDRNSDVGGEKFPIVHLLPEKPEDAPVELPESFRDLMNYYRTPRAFHPRATNTFLPRSWDIMSNFDAFAHNDMISPRPLLMITGTKAASKWYSEDSVQKAKQPKELYVIDGLTHADLYDKVDEAGAKCVEFFGKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGT1</accession>
    <name>A0A1Q5UGT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">pH-response regulator protein palA/RIM20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGT1"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="866" mass="96164" checksum="F0175CAB3FE33551" modified="2017-04-12" version="1">MTSNILQLPFRRSHTVSLSDAITQYISSKYDQRPDMFADDLMIIDRLRSEAVNVQEPHISGISRLVTYAAQLKWLGGKFPIDVGVDFSWYPALGFNSTRPVSQNNLRFELANILFNLAALYSQLAYALNRTTADGLKQACNYLCQAAGVLAHLRTDIIPDLRSSPPEDMDEMTLQSLEQLLLAQGQECFWQKAVKDGLKDASIARLAAKVSDFYADAGDFAVKSNAITTEWIHHMSAKHHHFAAAAQYRQSLDCLEKRKYGEEVARLRDSLACVNEGLKESRWISKTVLGDLNGLKSRVADDLKRAEKDNDVIYLSAVPPKSELKSLDRASMVASKAPSQVTDAISMLGDNGPLGQPLFSKLVPYAVHIAASIYSDRRDRLVNETLIGELESMTDKLRDLLSSLNLPGSLQALEKPLGVPGTVVSHAEEMRQQDGLNRLRRSVEDTARVKSNDRSIYNEGVELLAAEKAEDNAARRKYGTDRWARETSEAAAPKIYNSSKEISGYFTSAQSSDDLVERKLRDSEAVFRVLTGTNRDLESYVPSSRRAAIPPEVEREAIKLRSCLSEVSRMENRRRRRIQTLKDKARADDIHPALLRETARLEREFPMQAIQASQFEDLFEDSLRLYDSDNDMLAQERRDQEQISDQVREANLAFTRAHKGDASTKERETALQELENGYLKYKEIISNLEVGRKFYNDLAKIVSRFRDDAKAFVHQRRMEASQLEADISNVTAMASLRLSQPHLHQASPQTTRTHHQPSPYSSVPQAQTQAPAQPAPHPAPPAPAPVPVQMHSHRPSGTAAPLTAPQPVRAAIPPPSVPTPGMWSPEIGIRFDSAGVPPGANAGPATTAAGRGQGGTWDPSQGVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH74</accession>
    <name>A0A1Q5UH74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="80257" checksum="14706EB765B7C665" modified="2017-04-12" version="1">MYSRFDIVWPESLNPSTDEYTGVDALSYGLSTLVMGEDVFHQLPLPKHNQQSPACAHCGCNDPAHQPNQTQAVTPGFRSRRGNYYAQYTRTFSIGNGPLSWVQEYSVNREVGKMLGTLVALAVARMVNLEAFIWDMPTGVVREIWLALASLANRPGHECRLERVWVRWHDNSEHLLRPNTSLLSSLLSTLKNTHIEHPSLSVLPPLKSVTILDIDEAAYVDELAILIERSRDRLVELRIGISSKASVLNWVRCLKDTDNSLNSPKFWPRVAGVLSILSKPEEPAQQNGSITSSSAVEESVQSESSLSTEQDKERETEIQQETNHSSQGDDKQSSLSSNKRDVPLIAGVLTSTPKTRTPYYGDQANNDKLKLQVFELERVPLHVATLLPTIEWTRLTTLTLMACADHESLWRALRRKYAPPPVPANKLKGDRRPSIEASEYSLNLKHLRTDNVSPYLMLFIKEAIAPNTLESVYLHEAPDYDSTVQIDAIYKHILRRHRLSLRKVLIDASERFISGPDLPDSRWQKWTFNRDMVSFVTGGRMPQLRELGMAMDHLHWHHFLQRLPNMPRLYALYLTHIGNTPQRDLKELALQVLDIVSIRPDLKITYIGLQGKCYQILEGGREGEFDETPGVDRHSGVDDDGVFEEENSDGHQHFSALDDSGHLSSDLSDGYDDTEQEDEGVSRVRFRLQEILFYDDKISIFKARHGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHJ6</accession>
    <name>A0A1Q5UHJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHJ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013338908" evidence="1">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="140" mass="15491" checksum="E7AC22BF37D0CF66" modified="2017-04-12" version="1">MAITGWYCGTAFIALLQALRIEDLSKGANEDLDVLTLAVDQLRRMWPTAGVFYSGFCRIRPNSVASDIDSQRAPGPELGMGDGTGYMTMTDGIDWTTYFPFATPQTSAIASRLLVPHTEELFFDDDIFADTKLHIQDFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIM3</accession>
    <name>A0A1Q5UIM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="318" mass="34161" checksum="DF48ABDDA82BBAF5" modified="2017-04-12" version="1">MKQPYSPRSWSLRKKPIASPELLVGTAILAVLFNLIQGAKAQAYPDYSSIRYQLLDSYGGPSFFDQFNYFSGDDPTDDASTPNPSGGRNSVRVESKNTYNSGLFIFDIIHTPYGCGTWPALWLTDGPNWPNNGEIDILESHNHGSHGNEMSLHTTGGCSMDGGERRQSGTSLEGNCDIGSDGNAGCGVTGDLGTYGVGFNGGGGGVYALELRDAGIRIWNFPRASIPSDINDGSSPDPSSWGIPLADFPSTNCDIGSHFRNLNIVANIDLCGELAGTSTHYTQMYNCPGSCTDFVANNPSQFEDAYWEFGGIRVYQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIP7</accession>
    <name>A0A1Q5UIP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="622"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="701" mass="79470" checksum="EC9704294A02BAE0" modified="2017-04-12" version="1">MKGFRQRVHEQLSRAKDANKSSKKKESNSSQSQASLGISQTQQSASPGQGTPTSSTTSLNDARGKSPDNASPAGTPSSGATPAQHYIPPGAGIAGQPISNGPGTPTRQGQPVAPSVIISPSGPAPPGAAETMPGDLAPPRKSHVFDRLQTTPKDMSEGIRTPKRQHSSRFDISDQRQRELEKLPGFHEVAPNRRQDLFMQKIDQCNIIFDFNDPTADMKSKEIKRLALHELLDYVANNRSVITEPMYPRVVEMFAKNLFRPIPPPMTPQGEAFDPEEDEPVLEVAWPHIQVVYEFFLRFIESQDFNTNIAKAYIDHQFVLQLLDLFDSEDPRERDFLKTTLHRIYGKFLNLRSYIRRSINNVFFQFMYETERHNGIAELLEILGSIINGFALPLKEEHKLFLTRVLLPMHKVKSLSMYHPQLAYCIVQFLEKDSSLTEDVVLGLLRYWPKTNSTKEVMYLNEVEDIFEVMDPGEFAKVQEPLFHQLAKSVASPHFQVAERALYFWNNEYFCNLVSDNVETILPIMFAPLYENSKGHWNRTIHSMVYNAMKMFMEINPQLFDECSHEYTEHQNSADQREKSRQDRWDVIEQQATMRKNGAPPPPAPVLSVPEPIDEVEAMTNESQKRLNTLKIQEDTEAPKERPAREGTPNSTRRRGSVRGGSTSRRRRSGSGSEIRPRRRSVGSGTSATNVQILHRSNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIR7</accession>
    <name>A0A1Q5UIR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_2124</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIR7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="344" mass="38932" checksum="B150F4DA15F3D798" modified="2017-04-12" version="1">MADFLQKVPVPTLDRPFGVHLWPIFDKAYEQVMGYPASQFDFVQGVTPMSTFKQTATMLVTYYIIIFGGREVMKNFPAFKLNTLFMIHNFLLTAISAILLALFVEQLLPTIVRHGVFYSICDHRGGWTQPLIILYYLNYINKYVELLDTVFLVLKKKPLTFLHTYHHGATALLCYTQLIGLTAVQWVPITINLLVHVVMYWYYFQSARGIRIWWKKYITMLQIVQFVIDLGFIYFASYTYFSSAYFPWAPNMGQCAGEEFAAFAGIGIITSYLLLFISFYIATYNKAAKVGRPRSNTGKKSLIDMKNFEVPSPAGASNGSAKGSNGSASSTGRSNGPVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJE6</accession>
    <name>A0A1Q5UJE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000199">
        <property type="protein sequence ID" value="OKP12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="8154" checksum="EBC6CD60AF9333FC" modified="2017-04-12" version="1">MLLSIQSQSPTRKFGGPEEPRYAKVGQIGTDVYLWTHSLRVDNGDQRNIFSIDMHQVVRMDIESLCAFELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJN0</accession>
    <name>A0A1Q5UJN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine and histidine-rich domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJN0"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="34064" checksum="6F7C5F7CE80C2DFB" modified="2017-04-12" version="1">MASKCVHKGCGKTFADPEEACVYHPGPPVFHEGQKGWKCCKPRVLTFEEFLAIPPCTTGKHSTVDDTPAPEPVQATEEPAAPAPATAPAPAPVPVETKLPERPANAPEQLVVEETDSDDPDAVIPENATCRRKGCGATYTPSASRDVKCVHHPGAPVFHEGSKGWSCCKRRVLEFDQFLKIPGCTEKVRHMFVGKAKPAGEEKVESVRNDFYQTASSVNVSLYLKKIDKERARVDLAEKSITFDLPTSDNKRFQDTYNLFAPIHPEKSSFRVLGTKLELALVKADGTSWPVLRSDDKWSGERIQIGNAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJQ0</accession>
    <name>A0A1Q5UJQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJQ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="232" mass="26095" checksum="D132D083D31EA5F2" modified="2017-04-12" version="1">MFYQPGISEHNLPHDPFKGQACVVPRPIGWISTQNKQGQANLAPYSQFNNLTFDPPYVMFSSNQTVNGSRKDTVTNAEQTGKFVWNLATWDLREAVNISAEQVPYGVDEFERAKVTKEPATLMDVPMVYESPVKFECEYHSTVRLPGNPPMGTVDVVIGRVIAVHVKDEVLTDGILDIQKTKPIARCGYHQYTVVEKTFDMVIPGMSDDVLYGLEGNARRNREAESRNNLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJQ8</accession>
    <name>A0A1Q5UJQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJQ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="386" mass="42360" checksum="180EAD23EAA6AFE6" modified="2017-04-12" version="1">MALWGVLSACTAAVHNPSGLMASRFFLGFVEAVFFPGALFYMSLFYTKKQFAMRTAILYSGSQIGNAFGGLFAVAILKLDGKHGLEGWRWLFLIEGVATVGLAIILAFILPNSLKSITGLSKLEHEYLLWSFEEDHGQQDNTDEASVQKGVMIAVTDPKTWFFMGTLYCIYIAGAVTNFFPSVVATLGYSRNKTYGLTAVSDSLACDNNIPIIPSDTPQPPYVLCVFAMILNGFHSDKKQERYWHIVCPMVICLMANIIAVSTLNTAARYVAMMLMPGSFYSAAIVLLSWVTGTLSQPSIKRASAIAMINAVCNTPNVWASYLYYSPPRYLAAFLVNLAASVLAIILATVTRVYLQRQNHKLDRGLDVGRNGPTPAQIVVGFRYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK74</accession>
    <name>A0A1Q5UK74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="186" mass="20664" checksum="18523ECC562F0DB5" modified="2017-04-12" version="1">MSIPIQMIHIHYRGKFLSLLDSDNSTPLYTVKVCRETPQIQLMRRQDSHVPHSEDSTDSQSSLCTASFQKLSMEVTLSIHGSRVILRRPDTFSRTYGLESVSLPGTTLRWEADGALTGDFKLVNTRDCEVLCRFHNKVFSVAEVGSFEMIGTLSEELKNEIVVSGLAVLVMVQSLNLAGMVLMGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKJ5</accession>
    <name>A0A1Q5UKJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1327</name>
        <name evidence="1" type="ORF">PENSUB_1331</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000160">
        <property type="protein sequence ID" value="OKP12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000159">
        <property type="protein sequence ID" value="OKP12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKJ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="28884" checksum="16FA1D224ACC5DAF" modified="2017-04-12" version="1">MPNLGKIPREVFDLIADALLPNSTKNMADALLYSEKQENILWRVIFKSDEWIDKALEVEACPCLIGPTLDMIGKPDYNGPRRHHVLLSINDWNGDLQYFQHLLFESLREGYCYNKAKHKVILPETTFTNPDKTRTIKIPEIVLHINDVIFSYELIELKKSVTRRLFKPSTVQTQYSFATHKKIRVIQRPDIFGTRKTISKRRHLSPICGMYLLCNGKRWQTILKDPECPRVSPVFTAGRTGDIICWEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKK7</accession>
    <name>A0A1Q5UKK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000160">
        <property type="protein sequence ID" value="OKP12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="57" mass="6766" checksum="2612120F9B934007" modified="2017-04-12" version="1" fragment="single">WRTIYNSDGTGRWLQQEHHLETLVQYKNVWQRQVPPIKGGRPRNITPVMLNALCDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL73</accession>
    <name>A0A1Q5UL73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL73"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="510" mass="55888" checksum="323AA27B5E5B246B" modified="2017-04-12" version="1">MALPPKWYQFLVCVFASLGSVLYGYDLGVIAEAIASPSLVNAFNVDATKSGAVTSVFTGGAFFGAIFAGPLGDYAGRKITILVGAIIFLLGGGLQTGAQSLSFLYAGRSIAGLGVGILVMIVPLYQAELAHPDIRGRITSLQQLMLGVGSLVAAWISWGTYINFADDDSRQWRISLGIQMVPAVFLAALILLFPESPRWLIDHGRLDEGLQTLARLHSGGDINDPWVQTEFDQIQTSIASEHEAEAKSYTELFTDPSCFRRLFLACSIQAAAQMTGVSAIQYFSTTIFKQIGIATNDTLKYQGISSIIAIIAQLCCLLFIDKTGRRWPQIIGNLVNCVFFIIPTILIAKFPPGTTHNNAASWAFIVMTWCYNFSFSATIGPLTWVICSEIFDTKTRSKGVSIATMTSFAFNTLIGQVTNVAIERIGGWRFYIVFCVCNFTNAIFFWLVLPETAKLPLEDMNSLFKTEPWIVPGTQTRKFMERSKVGNSLAIAARTKQDNFSLVHEEEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULF3</accession>
    <name>A0A1Q5ULF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="185"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="398"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="604" mass="65677" checksum="8D8455A939FA30AE" modified="2017-04-12" version="1">MTDLPFPGGASRAPTYGISSGPRRSSYASVVSGTAFSPPTPITSSFPHIFNTNPVSSYPPSQPDGRLPRALSGLDAADMHLNSAWRTSGSPDSLPAYSRKYAGYLRPSEFPHGLGLLDGPSFFTPSYLRDSHYISRLDAAHRAKLAAQQRDVSSSTSASGPALSASSSHVHLPRLAPSHHRGVAYEVSEKEPPAVTSDQVSPLPTQWSSSDKYAGLELSNDGLDVRYTGPVHKHDHEAAALRADHPMPPQCGIYYFEIKIESKPKEGMIGIGFSSPKASVERLPGWEQESWAYHGDDGKSFFGESQGQGRPYGPTFGVGDTAERASIQSEINATSTDSLQPPLNESALLQELVAQFLAHDGYVETARAFAEEVATETAALQSGQREPLKKYEVEEDREAINRNKIRAAILDGDIDKALKHTKAYYANVLESNPQIHFKLRCRKFLEMMRRSTELTPGTSSNPKRRRPDSPGLGIADEHAVFDQEMELDDGTWDGGDGMDTEDQEPTSAAPFNEVLTEAVQYGQQLCMDYPSDENGGDRKMLEDIFSLVAYPDPLNSVHGHYLDPAGRVAVAEELNSAILEALVNEISEDGGAGAFINVRNDVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULL3</accession>
    <name>A0A1Q5ULL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 19">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_964</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17 19">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 19"/>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULL3"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="358"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKP13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="412" mass="46023" checksum="AA0550EFBFBA3D6F" modified="2017-04-12" version="1">MEQSFDLPDSTDWLGTPLSLLAPLESSLRCQVCKDFFDTPVITSCSHTFCSLCIRRCLSTEGKCPTCRSGDQELKLRRNWLVQEILEAFKNARESALTLAKKEAARIAAGDNGAPETVPKKRKVSQVDNTEATDIVQGSPQRVRTRSRSQMAQAQAQTDGQDRSRPSSFQEVIEDSQDEDFIPGSALVTQDQLQDQLKIQFRQSNRHSGMLNPTAIRGFKSNSSYSRLLQVQSRQPPISPSKPLDRLPAMNYSLLKDIQLRKKFRDLGIPDWGPRQLLQRRHTEWMNLWNANCDSTFPKTKKDLLRELDIWERTQGGFAPTQSSLMPTNTVMAKDFDAAQWSVNHETDFKRLIANARKKSDDQVRSTIPGAAQSSVSNTAGVDNSAQPASGVERSAPIEINSDSPAPGDISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM12</accession>
    <name>A0A1Q5UM12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM12"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11178" checksum="70D37123938ABC84" modified="2017-04-12" version="1">MFAFIHAWVKANGHFDISPREALAAPTTDEGTYIQSIVILTFSVVSFIAAGWIVLSFASVLVLSRIYYRGPEPAVGNMGFCEPKQQKDQEGTIDAYNMCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM72</accession>
    <name>A0A1Q5UM72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM72"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM72"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="479"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="659" mass="72976" checksum="51420613B67BDC4C" modified="2017-04-12" version="1">MPVFTEYAAASRELRVLPSFASPLPRLTPKPQPDGKTERYEVVIVGAGPAGLMLELLLARYGLSDESLLCVDAKSTTLKSGQADGLQPRTLETLKSLGLADEILTEGCQMWQVAFWNPSNDEDKIIERTSIVQDVAVPARFPHEVTIHQGRIERILETDLLRYSKRGVQRNTKLIDVKIDEEVDAEFPVVAEIETEGQHRTVRTKYLVGADGAHSVVRRSMGLKLEGESLDHIWGVVDLIVDTDFPDIRRRCAIHSPAGSVMVIPRERIATGDYLTRLYVQVPGDVKPDSDQQTTDGPIAAPTADARARRSQVTEKTIFDNAAAAFRPYYIRPKTDGAVDWWAAYQIGQRVTDKFSVKDSKGVNRVFIAGDACHTHSPKAGQGMNVSMMDSYNLAWKLAYSIHGLTPEGAQGQPDPILDTYHTERHTIAQELIEFDRAFSSMFSGKIGASEDGVEGLTHEEFLEVFSRGNGFTSGCGIEYPENIAVDRALDGDKNPISGTDYLSGILRPGRRLLNVRLVRHADGYRRDLQDDFASTGRFRILCLTSSDLLVLQGTSSLTLTKLGAIISQFPQSVLEQVVIHPRLSKEFVWSDIPSEVKQHSEMSFYSGYKMDDVYGIYGVDPSKGALAVVRPDGYVGILADLGDVQRIDNYLGTMIRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMB2</accession>
    <name>A0A1Q5UMB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein saf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMB2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="33191" checksum="507EAC5B1A978C05" modified="2017-04-12" version="1">MAKDKERAINPAAQQRKQDKQKSLKKGKAEQLARRNEKLARRNPDRLQRQINEFKSMEESGQRLRPRDKEVLEALERDLRAVLKAREALGDKAPKFSQGGRDGPHGPRREGGDHVLGKRRRDNTFGRQEESDGSETDEDVRRIPMPRDTPPPIPREHQRKRGPTQNEDSERRGPHALPSRPPVVEAKTVYEAKPEIRDLRQEAVNKFVPAVVRMKQDSIRGAGKLLEPEEMDRLEKAGYTAGPTGTKPSTTTEQDSTAEELRLLEEEERRFNQEMKKHAHMEEVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMS3</accession>
    <name>A0A1Q5UMS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase A, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMS3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMS3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF9">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="281"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="10">
        <location>
            <begin position="436"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="530" mass="58695" checksum="9988A145B127AC2E" modified="2017-04-12" version="1">MLRRTAGEVLKKSPNDVVVLSAVRSPITRAFKGGFKDLYPEEILMPVMQAAVQRAKIEPGQVNDVLIGNVLAELGFAKTGRMALNAAGFPNSTTFHTVNRQCSSSLQAITHVSHSILSGQIEVGLAGGVESMSRNYASRGIPTDVSTTLKDASVKDARDCLMPMLQTSENVASRYGISRREQDEFAAESQKRASEAQKAGRFNAEIVPIHARHVSEGIDEITYQIVDRDEGVRHGATVEKLSTLKPVLENGFSTAGNSSQISDGASSTVLASRPWADAHGLKPIARFAGTQIAGCAPDEMGIGPIFAIRNLYKYLGIENKDVDLVEMNEAFASQSIYCLRELGIDMSKTNVNGGAIALGHPVGATGARQTATLLAELQRQDKEMGIVSMCASHNNDQDYVFQSFEKGGPFSTIKDFNDWFSGLSQSWLPLSKKYKDLYRDLLPDNGEIEFTHADLHRGNIMISTCNPVRILAIVDWEQAGWYPDYWEYCKALYTCWYEDEWRREFIDNFLYPRMQEFWVFSEYTMSMGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNB3</accession>
    <name>A0A1Q5UNB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000121">
        <property type="protein sequence ID" value="OKP13949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNB3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="87" mass="9191" checksum="FF1151A14126CA5E" modified="2017-04-12" version="1">MAETGVDYLQSRHLKVLGGILASESGNDAGSGGLASLSAETTRLLDILAGDHFKSQRHDAFGGAGSIVLGCSRFREIYKSEHVARDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNK4</accession>
    <name>A0A1Q5UNK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="10256" checksum="3040633F4DB6755E" modified="2017-04-12" version="1">MGFGRQNYYGSLDDAEKRRGIGSNPNAALGTGACLARFHLIKNFPKFSYRTIDRRPASFSSGIIVSIVPTMVRVVESVLSPLYTSDLISDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNZ2</accession>
    <name>A0A1Q5UNZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000107">
        <property type="protein sequence ID" value="OKP14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNZ2"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000009">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000316">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002647">
        <property type="entry name" value="PRK02318.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="395" mass="43732" checksum="C65085756446B1BC" modified="2017-04-12" version="1">MGMKAIHFGGGNIGRGFVAEFLHTAGYEVVFIDVMDSIINELQNTKSYQVTEVSEGGETTKTITNYRAINSKTHEQDVIQEISTADIVTCAVGPNILKFIAPVIAKGIDIRSTPKPLAVIACENMIGATDTLRGHIESHTDSERLKTMGERAQYANSAIDRIVPAQPPNSGLNVRIEKFYEWVVEKAPFGSVGHPDIPAVHWVDHLEPYIERKLFTVNTSHATAAYYGRYAGKKTIAEAMHDSYIRGVVRDVLKETASLIIDKHEIEAQEQQDYVETIIARISNPYLEDSVERVGRAPMRKLGRKERFIGPAAQLAERGMKYESLLGSVEMALRFQNVEGDEESVDLAKILKENSPADATVQLTGLERTHPLFSAVVKVVDQVQSEAKETGQPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPQ0</accession>
    <name>A0A1Q5UPQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPQ0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="268" mass="29820" checksum="3648B68B74A96FC1" modified="2017-04-12" version="1">MHAGSQRPEPGSPPPPLPVDSRIAMQPQDAIEQQPPTLLPPAPTHQQQQQYHQQERIQSHQYIPSEKERHLQEEGIIPTYSRYPPPEQHPAFQAPFSPPPEQQHHHQIPQYAYASPPSSPGPLPLKTHEPPKRSDTLSIEPDANPLQSPKTSYFPPPPTPAVHGSHAPPGEDLSAFHQPGQIMHPNQEVEGLLATIQHTRTRKAYGIEGDVCSDCVRATCCTCCTLIQDEKEFQKREERRGRAARERGATLLSPYTAPGPMTYGLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ25</accession>
    <name>A0A1Q5UQ25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ25"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="464" mass="50714" checksum="DD6BEE4755A756E1" modified="2017-04-12" version="1">MALRSALSLGTNLHITDGRTHDASKEARCRLWWSIYSLEYLLTSMHGRASCIGEGLCSVPPPLPFEEELFEQPDIARLLQDRSLREAQLRPTLFETPTQLQSGPTWVADCKPCSALFFYHLTDLALITQAVLNKIYSIEGIREGSSVTEYRLQKYTLRMDRWLAKVPPPYQFTVPDAGPWHLNHAQLDDQTAPFARERVCLAMNYYSARVILCRPCLSQTHSPQQPSSSSATTTPPAPDANHRAKLRTDMATDCLQAACSLISILPENPDIAWFVRITPWWSVLHFIMQATTALLLALSFVSFPDQTTLPSSSESTSKSKATSNSNSKSASASASVSVSGSDPVIPNALALLDTDIETVIAQSKKALHCIHTLATVDPAARRAFLLCDGVVRRLAPALKIDLRDWPRAEGLVGGAGVDVSNMQRESQGQSQGPGQGQGGHEGSVDDGSRMEGLEDLLDFEGNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQF0</accession>
    <name>A0A1Q5UQF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886141" evidence="2">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="10158" checksum="11EDD67D67045787" modified="2017-04-12" version="1">MKFGAIVSLLCIAVAPVMASEDVTSVSTTTITKTLIRVNSVTATPSSSATLVSVSASATSTPLVSSSSASTPAAASPTKTGGAVALGAGMPAALVAGSFALIMGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR88</accession>
    <name>A0A1Q5UR88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A thioesterase THEM4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR88"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF3">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G03960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="23807" checksum="1072989992CEC274" modified="2017-04-12" version="1">MYSHSYRELIKKFSVSQEDVDFFAKMPFVRSYVEESSAYQPVPFVTRYDKGDSSDRFFNKTINSDDTVPRVLALMRKDYSLTISSTGNEDLEQSQVPEEPHFVVCYQLGSGVNGYVNTAHGGVLAALLDETLGLCAETYRAFVSSEPEHLLTAKLEVSYHSPVPTPGIIVIKAWVKRKEGRKWFLEAHILDQEGTLKATAKSLYVRLQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URV5</accession>
    <name>A0A1Q5URV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tryprostatin B 6-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URV5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP15213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="685" mass="77614" checksum="5B222F018B2213D0" modified="2017-04-12" version="1">MDPVNDFTWTNRILVWCADLLKFCFGEGKSLPFSEKMKRWSVLKAFDLKWESNKPLEFKPLYFEEADPSSGKFFPVIWHQNACQAVGSQHIELSRILLAVSDPKLSRLGLAARQANLALEEELRCIIRRLVGLALSNSKCPVLFVNAAVGISVCGEYLKDPAEQNAVLEFLADLEFQHAWPTAASASALKEAWQGLRKYPNHSFLSGITDIPYCYLSACGFRSRDLTKLHDKSPILRIGPNNLSFSGIDAIRDIYGHSTSCVKDLKYAITAGTHPNLFDVVDKPNHAAKRKRLSAAFAIKNLEAWEFKVARTTERLLEAFDKLCTKPLPSDSVPEPADLTVNFNQWVNLFTIEAINSIALSSDLGLLEKGDDLVTAQRMDGTTYQARYRKSQNQGAYATSHFVWDYNNFKLFVRLSKLFSHWRKVWSDAEPFKDIIQHQAVTRLDRYNKGEQLDDFFSALMDDKTGKPYNSEWGEIVGEIAAIIDAGADTTAIALTQILELLIHHPQHLAMLREEVDSVLSPDDIVAPYGKVKHLPFLRACIDEALRIIPPTSAGLPRRTPPEGARILGEWIPGDTSVSMTIYSAHHDPTIFPNPDQYQPHRWMDLEQRKRMEPYFIPFSTGARGCIGRNISYLEQTVVLASLVHRYEFALPSAEWKLQRFEAFNLLMGDMPIKLWRREIPVQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMW7</accession>
    <name>A0A1Q5SMW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="9984" checksum="5E4C331123183437" modified="2017-04-12" version="1">MTTNHDTDTSEDDSLMAQANEQLKRELLQSQKLTLATYRAPRRVVSLGISPGYVKDWTPADAFRELYQNWYVLASSAGQTLIHAGRTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SN30</accession>
    <name>A0A1Q5SN30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SN30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SN30"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="17236" checksum="2298A81935DAE7CD" modified="2017-04-12" version="1">MAASTGRGATVKQLLGTDGVDSDPRDSNEQTPLSRAARRGQLEVAELLIATEGVNPDSRDSNGQTPLSHAAQFGKLAVVELLIARKGVNPDSRDNNGRSPLWYAAEYDHGDVFQLLLSTEGVDPDPKDSYGRPPPSFDLYRQTRWNSLNFLSSIKPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNZ6</accession>
    <name>A0A1Q5SNZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNZ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNZ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO89724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="11176" checksum="0BCAD371CAE01D95" modified="2017-04-12" version="1">MREPLATTFACLFCNHENSVIVKLDKKLGLGDLSCKVCGQKFQTGINYLSAAVDVYSDWVDACDAVAKDTANQYDGHVGSIGNSKSDAMASAGHGDTYENDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQP1</accession>
    <name>A0A1Q5SQP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQP1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="215" mass="24216" checksum="9729D16F28EE9573" modified="2017-04-12" version="1">MAAQAPPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLTFTTNLGTIQFDVWDTAGQEKFGGLRDGYYINGQAGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVAAPALAPPEVTVDHEQLEKYRQEMADAAAQPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQT6</accession>
    <name>A0A1Q5SQT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQT6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQT6"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="310"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO90364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="400" mass="43667" checksum="E42B0FA6EE0E35F2" modified="2017-04-12" version="1">MSNGYQTSPPNVALCVTIQDFEAAAKAVLPNKTWVYASSSAASGLSLQSNLDDWSRINFRPRIMRSVSSLNPTRPILGHPGSQPFFVSAMGTLGNAHPGAEPLLVRGATRKGLHTVVSTATSKPLEEIMEAHLDEQRQLGNQSPSKLAFQLYVPVDRNLARSLIRRVKAAGYHSLWITVDTSTLGKRTADRYLQAQEALDQGTRETTREAAADNAFGPAFGGRPVPGYLDPGLSWEDLEWITEEWNGPIVLKGIQTVEDVKLAVQHGVQGVLLSNHGGRQIHSAPSALMTLLETRTYYSEAFDMLDIYVDGGLRDGADVLKALCLGATAVGVGRPYFYAMAAYGIEGVEKCTDILAEEVEITMKILGVSSLDQLGPDMVNASRLLNEMWRPDIWWNKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK3</accession>
    <name>A0A1Q5SRK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-2-oxoglutarate aldolase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13354</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK3"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO90637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="32941" checksum="D3B5C32B08137E84" modified="2017-04-12" version="1">MTANGTHKRNPLPRGVYVPTVAFFQPNEDLDLATTEKHATYLANSGVTGLVTQGSNGEAVHLDREERKAITSATRRAVDAAGYPHMPIIAGCGAASTRETIQLCQDSGAAGADAVLVLPPSYYKGLVNTEALHAHFIAVADSSPVPVLIYNFPGASSGLDLSSDDILALAKHPNIIGCKLTCGNTGKLARVAAGSKPEFITFGGSADFTLQTLVAGGDGIIGGTANLIPRACVRLMELYGSGKVEEAQKVQAIVARTDWAAIHGGFIAVKSALQSYRGYGALPRRPCVVPSETAAAAIHEEFREGMELEASLGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK8</accession>
    <name>A0A1Q5SRK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52938" checksum="882FB255F368D341" modified="2017-04-12" version="1">MLTGLQNWPMFKKLSVFTAVCLAGFAAQMSPNSNQLTFMEQVPTYHSTPAALLNSVAAGLAGWVAGPFFFIPLVAVIGRSAVILWSLVAIFACQIWAGEMTGPDDYISFTISRLICGLFGGIPAILGSGYIMDMFFLHQRGKAFAVFEVLIIFAVVGGGTLGGFICETNPWDYVFWWTLGPVGAAIVTVFLFVEDTTYSRDPTRPNRDPLPKGWLAKRVATFLPGTKTQPADKGKEMIRRAIIPFQITFSPITLLTGTYIFVALGLPIMQASTLATYLQPPVEEGGYGFSSLQMAFFTMTAWVGIIAAQVYGYFFNDKIPLMLARRRGGTWHTEYRLANTILPSIILPIGLAIYGAGLEYHLHYMVLALAGFLIWFGALLALPVCYNYIIECFLHNPVEASVSLNAYRVSFGLMSVFIVTQWQAAVGTGWMWGMGAFFILFVDLIMAGIILKGHLVREWTKSVSSTIGVTEDGARISAGVSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSD4</accession>
    <name>A0A1Q5SSD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSD4"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="127"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="523" mass="57096" checksum="ACFA12E8950F484D" modified="2017-04-12" version="1">MSTEARLTSNIPDAAGDNDYGHLHNNHADESIVAAATEKQISTHNHEKTGQVESEKTTTEVTDFEKQVPTSSTNQVHEQEQTTTKEDDDLYRAASTIAPSHRSVHRDPMSRVTTDAEGNTYPEGGLEAWLVVLGSFLGLFGSLGLINTIGTFQAYIENHQLKDYSSGSIGWIFGMYPFLTFFCGVQIGPIFDARGPRLLVFAGSICEMAMIILLGFCTKYWHFMLVIGVLGGVGASLIFTPAISAIGHYFYARRGVATGIAATGGSIGGIAFPLILEALFPKIGWGWATRVVALICLIALGVANLLIRSRLPQKPFSKENVLPDFRIFRDIRFTLTTASVFFIEWGLFIPISFISSYALDHGFSTQFSYQILAILNVGSFFGRWLPGFFADFLGRFNTLIATVALCLLCNACLWLPSGDSLALLVIYALLFGFSSGSNISLTPVCVGQLCKTENYGRYYATAYTIVSFGTLTGIPIAGEILTRCNGEYWGLIAFTTVCYAVGLVCCTAVKVIEVGWRRPLAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSE8</accession>
    <name>A0A1Q5SSE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSE8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="12959" checksum="35CE983CDE5DF25B" modified="2017-04-12" version="1">MVRNEARATIQGSASLLSAFDEGNYLLSVVYCKECKIAICFCGEVLRQDYRITVFLGLPTSLNLCPMVSLVSLGRARGGCYLTCSNIKEHERVRCRHESVAEHLVSQSSMCEDHIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW07</accession>
    <name>A0A1Q5SW07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW07"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="31840" checksum="B1F571B046AD3EC4" modified="2017-04-12" version="1">MINQQDLLSHKSPKLQSIQRSIYFGSTTSKMRSLLILAGYITASLFVSALAVPTDPLGLETRNDLAKRSLPRLVNFDNNNADDRKKSLKIRQSFRDSLELMDYAIKSLDDTVFSHYFDKGDKSKVQDVFKKALGGNPSRGADELGDMYITNIDVNSQCGDASLLGYTGKDGKGNQIIHFCDRLYNKPLIKDVKCGDLEDTVGANMAVMGATLLHEFILGQSIIDVKNGYGPLETRSLKASDALKNADSYTWMATENLWTVICEKKFSGPRDARDTADPDCGDKTCTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXY6</accession>
    <name>A0A1Q5SXY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interferon-induced GTP-binding protein MxA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000737">
        <property type="protein sequence ID" value="OKO92891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXY6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXY6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="560"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="650" mass="74120" checksum="3AEC55A9EFE619FA" modified="2017-04-12" version="1">MTRQRGIDLTEAEGLDNEKRLRLLGIIDRLRELGISENVSLPQIVLRRAPAEDAEARITIIPGPTSRLDEALNQRLLAFERRLAAVEFGYQEFEDIFDEAATCMGVPGPKTANLEDVEKRFSDDILKIELSGPDHRHLSVVDVPGLFHNPTKFQTEEDRAIIRKLIQDYLTDKRTIILVLTVSRFSMARAADPAGKRTVGIITKCDALQAGDEAGVLSIAKNEVERLTHGWFVVRNRSTQEIQAGVTIEERHRKEKQFFSTAHPWTELRKDRVGINALKSFLGHLLYDHIRSEFPAVVEDIERLSLETQKELEVLGPSRQTPAEQRRFLTRISTTYQNEVEKALRGNYSADLDALSPLKLRMHIRQHAEDFAKSMATNGHAKVFRTIRDESDPEFQRPAADSENIYDWIRRCYLESRGSELPGTVNPVVLENMFRQQSSPWEKIALRYLENVASSVHSFNKETLSSILPDDDIREKLWGILSPPEQETYRKAHDQLLNIVNDERDGVLQTVNHYYADTLSSIRQERVTVRLEQLGLSNGMCFDMSRVLQGVHLSNEDQAVFDIHDILKAFYKVAMKRFMDNVVIQVCERYILGDGGPVKTFSPDLIGDFEEDKLTEIAGENFTTASRRNDLLSKAARFREALEIAKRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ67</accession>
    <name>A0A1Q5SZ67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAP-homologous protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1257" mass="136466" checksum="5FFB38925D4F018A" modified="2017-04-12" version="1">MEGVQTVDASRKARSVYWRPAGTSLGGSIRCLSWATTDLPPLDHLSRTKSVSSTISDKPSTDKSSTTATSNSHRRSRSNSSPAGPPSSDKPPPKREPQNDAIKVEEKGQASEKTAEPPKQPPPQQQQPSTPSPAVQKSSPKPVGGRRGSWISSLSSKFSSGSTPPSQSTLKGSPASPKATSPLDAHNPFGAAYFPKESSYDEKKDDSAISTSTSPKGPSFIHNALRKFSSNSGGLPKLPPNGVICPRRVMNVDEGRDRCKITELNPAKLNRVAFCVDVEIAGVSHRDSDEDAPPTNQLRQPLPESNRQKSKNADVKEKSKEETAAPKKPQPAVTEKEAPLPPIPQETGSPDTPSTKPPTPPATEATTPKTSTDVKPNGEAKDPTRKQEKKKRSEEERRERKERKRRQAVANGSIPLQLDAEHDEEENRAPAAGISRSKTQSHPTTDPVRIYRRCCQLRETPVLKRIVDEISSPSSTLAESPGTVAALDLSNFPMTAQDIATFSDWLAVVPVRKLILENCALTDDSVRAILSGLLSTKTVEQMRYRRRRARKPDSPIVKDVRWGVVEKLSLKNNPKIGREGWRHISLFIHLSKSLKAIDLSGIPFPKPRASSDSSTGSVGQPQASPVDVCTIFADALGERFGGEHLEELLLSECMPSMDQVKKICVAATKMRLRRLGLANNGITREGLEHVIEYLKDGNCEGLDLGGNLIKDDLDLIVAAIEPEQPLFALSLADCSLTPSVICPLLQALTRLHNLRFMDVSHNPALFSSQPSSLGAFRRFLPKMPSLKRIHLADVDLSPDHVIGLAEVLPECPSLCHLNILENPQIAAVASSTDAAAQEEACAVYASMMAAVRVSRTIIAVDIEIPTAENNEVVKALASQIVAYSLRNLEGGAIAEELSESIISSPTRDVPVPEILQHIVGHANGLEEPYDEEDDAAPDEDYVIGGTGVVKALGVCLGNLNQDGGDALGDQSAPPSGTTTPRRRKSRGVVAKRPRDMSKNLLESARNIRARIQSALIREDRAGNDANYRRLQFLDFTLHRMIQRFEDEYPETRIVPQPAPTSAAPDNTSQHSGEDATGPSVAGNLNGSVMDNENAIDDEETDHYAIHLSRTSSITSLHARAMTSEEGHLHRLGQNLRRDFLNPPLSQGDPDDDAAAHLVALRERLERMHEQQSQSPFDSAEAEEAFEKLGSTVDELWAAQRQDVEGFERFKQSQIAAQINSGLRLAASMPSASSGEPSKKSPLANTQQSSENKSPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZJ1</accession>
    <name>A0A1Q5SZJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZJ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZJ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="18683" checksum="1FAF5891B5DCCA97" modified="2017-04-12" version="1">MASLKVLFTSPEINPANRKALTIPIFNPIDRYGRVFFFACFGFMVAFLSWYAFPPLLTVTIKKDLHMSQQDVANSNIVALLATFLVRFIAGPLCDRYGPRLVFVGLLLAGSLPTAMAGLVTGPKGLIALRFFVGILGGTFVPCQVWCTGFFDKKIVGTANSLAAGWGNAGGGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0P5</accession>
    <name>A0A1Q5T0P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0P5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0P5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="62"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="464" mass="49795" checksum="4498916E993D87F2" modified="2017-04-12" version="1">MSDPENVAHAATNVPQAESQVKKATMKESNSPAPFPTSDVKDYDLSEAEQQITAAGEAKYSRLSWKQLTLMLIVDAIALGALSIPQAFATLGMIAGVVCCVGIGLIAVYTSWIIGKVKLAFPSVQHYGDVGGLLLGRVGYEVFSAVFVIQLIFVVGSHCLTGTIAFATITESTICSLVFGIVSAIILFLFAIPSSFADITILGYIDFASILIAIGITIIATGIQGSNSPGGLATVDWSAYPKENVTFTEAYVAIGDIVFAYSFATCQFSFMEEMHTPTDFTKSIWVLGLIEIIIYTVTGATIYAFVGPGVQSPAILSAGTTISRIAFGVALPVIFISGSINAIVVGRLVHGRVYKNSVIRYINTPKGWMTWILLVAIITIIAWIIAEAIPFFTDLLSIISALFTSGFSFYLPPIMWLVLLCKGKWVSKENLPFAVINFLVFLMGLAVLVCGLYSSIDDIVSFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T243</accession>
    <name>A0A1Q5T243_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T243"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T243"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="10599" checksum="AEDDB955D760A968" modified="2017-04-12" version="1">MPGGIATGLQRHVDSETLKQWGSSEPAKKYGKSPAQGATTTMTAAVGKEWEGKGGVYLEDCQEAGPIPEGGTLAVGDAPHAFDPEGEKKLSALSLKMLNLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2J8</accession>
    <name>A0A1Q5T2J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfite oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2J8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2J8"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="7">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="41328" checksum="0C8549F579A3D9F8" modified="2017-04-12" version="1">MTSPESTKKAESSDQPLNREPSAKVLVDHYDRNHGPIPHINNEGHFIRVGGLVKNPLLLSVNQLRSEFTQHEVTCALECAGNRRHTMRTLIKEVQGIDWGDAAIMNCKWKGPRLRDVILHAGLRVDVTDPTREFHVAFASYQAKCQEEEWFEASVPLGMCLEIERDAILALEVNDTTLESNHGYPVRVVLPGIVGVRWVKWLDHIIIQDHESRNIYQQRDYKVLPPAAVDTESAKKYWEETPPMYDIPINSAIAVPADGETVTLSSTGTVQVKGYAIPQGVSGPVTRVQVSGDGGDSWVDAQLNDSEKSMKWSWALWTANLKLPPGVQREILSCATDAGLNSQECEHSQWNLRGVGYSGYGRVRDLTVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2L4</accession>
    <name>A0A1Q5T2L4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2L4"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="417" mass="45274" checksum="4B59678322F09B06" modified="2017-04-12" version="1">MLALRDQENLVNTHQTAAAAKPLNQGINKIPPKTPGKSVPLNDENNPRAFGKGTIKGNKSGQENGKPALNAFVTPGETRQRAVLGNKTTNLKTNAFKTPGPFGGTSKPEKTNNRRTSTVQRIKKAAPVVQQAQTKVYTEAAQDDVPDIEYMPPKPTALLDEPDDVTYDTTFPQFKPKHRALGLESVYGKQEIGSDGLTKKQRKFQEDSVKCDKMINDTIMKQLDSISFTEHTEDVAARAPKPRLQSTHRRAPSTSVRPTRQVPTIRSREAAAALAAPRPSSAPVRTVAVPKSRVASAASALMPRKHTRTPTNPSSMRSTAAAVTSNTTVGYSKGRSVSSTLRETASAQKAANSEALLSPETYMQLYGMPPLDSEMWIRCKAAGCFDSAEESAASQELEEQLPTFEEAEEADSFQLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4D6</accession>
    <name>A0A1Q5T4D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4D6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="8197" checksum="8CF5434A27A1FC6C" modified="2017-04-12" version="1">MAHIDPLIIARDGDLLIVVSDTLNQITNRDHQPHQDDLASRTRLPKGDLQYTSFQVSSDRLAMESRYFEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5R9</accession>
    <name>A0A1Q5T5R9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5R9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14153" checksum="0ECBBDF30DD4CD16" modified="2017-04-12" version="1">MGKWTLDGVKIKDGSPRSHGWGGHVKGSEIIEAPGGGPTYEEIGFLSKHRSQSLVKDSMEESEGMVRRLSRPNRHPQNQGRDLSRAATGESREGAGGCVGCGEQAGVGGRKFGDQEFQMGLLRLAWFSGCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Y1</accession>
    <name>A0A1Q5T5Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquitin conjugation factor E4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_11166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Y1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Y1"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="985"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="810"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="810"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO95654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1072" mass="121811" checksum="432B050E024431FA" modified="2017-04-12" version="1">MSDTLSDAEKIRNKRLAKLQNPAASPRPSASDPPNSPPTSSNPSRAQSPSPSLSSLNQFDGATDSPPSTTQTSQQPEGKRIKITPTTSASVPERPRSTGPSSAQTNSPARPIPQRIEDFEHQVLGNLFNITLKEGALETNSPRIFLPGLQSELQDEGKELRLHTGILDQAILEAASKAEKQGPLDYLLPCWSRIQERMKKPDPDTRKWDIYGEAKRLCLSYCIFAITMPEMFGIESPGESPLARQLLLSPDDNSRRGITPEFLKEVSLKFDEDDSIKPALISAVEDLSAQLSSMDANGAFQPYLMALRNLVDNKIIAAAITESSIFNASKDPAQFEKTTLLGPWFRLSPLQPSATMSYFSNPKSRDHGFILNSQSSLRMMQNMIQWDLDYITGKILHASTEAKNRFLDWVATALNINHKRRAMQVDPEQVASDGFMFNLTSTLDKLCVPIMNIDFRKIHTFHAEYFQKNPRIDMRDETKINADQHASDAFYAKKLEGASNFNSELFFLTIAAHHYGSESLTSRLDQLDKDLKHMESTIVKLEAERVKWSANPMQLRVYENALKKYRDKFDLGLALKYSLQAVLFDEQWQVRSIEVIRHIAAWLLRVASGVNYPEEKIGLPLPQQQPEVFQNLPEYFLDVIISNFKFVSWAMPQTITAGLGDELVMLCITFLESSSYIKNPYLKAGLVSMLYRGTLNRPGGQRGVLVDLLNSMPFANEYLLHAVMRFYIEAEHTGAHTQFFDKFNIRYEIFQIIKCIWPNTLYRKKLSYQATQNQDFFVQFVNLLLNDVTYVLDESFGAFKTIRNIQEELRRDGDSMDPTTRQEREEHLATTQRSAKSYMQLTNETMGMLKLFTSALADSFTMPEIVQRLADMLNYNLDAMAGPKSSQLKVEGNVQLMVEKYGFDPKVVLSEIAKIYLNLMNKQNFITAIARDGRSYRPELFKQAADLLRQHKLTPDEDLRRWDRLRKLAQEAKEADEQAEEDLGEIPDEFLDPLMYTLMEDPVILPSSKLSIDRSTIRSHLLSDPHDPFNRVPLKIEDVLPDTELKAKIEAFKAERRGRKEPAAEQMDTSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6T7</accession>
    <name>A0A1Q5T6T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6T7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6T7"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="465" mass="53534" checksum="E8D488093781EC05" modified="2017-04-12" version="1">MPQQKTSSLKTYFDELEETNGDDEFRVWLSRAFDARAELATFFADRREGRGTRRYIGFLKGSFNLSFRFSFDDGKPDVTIRFPKPGHTATALRDEKVVNEEVQIMEYLRQNPNSPIPRVHSWGLLAESPRQLGPFIIMDYVHGTLLSTILRQPDTEDVVLNPNIDNRMLDKIYYQIAGYMLQLSQLTFPRIGAISKDNATSTWHVTGRPLTYNMNELATVASYPVDQFPTGPFDRASDYLKSLANEHILHLQTQRNLANNPKIAQKRFIARHHFAQLIPKYYPKDSGVCIPFCDDLRPANILINPETLQITAILDLEFTNAMPAAFTYDPPWWLLLTGPDLWLERDAMEEFVALYEPKMELFLSALERAETERAIEGRQKAGGMALSSRMRESWRSGRFWFDFAARKSFDVDMVYWAAFHDDGDGKEVERLGGMACADMESFIQMKMEQLEAYKEECTARFSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8H8</accession>
    <name>A0A1Q5T8H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8H8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8038" checksum="1183C06235EDD7F6" modified="2017-04-12" version="1">MRGSDSPGFSTPLNFIHQTKESATSEVGDEVDLIGGREARGVILVTGSEWIRGIVLVWGGGDSYVLYNGVIVWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9N9</accession>
    <name>A0A1Q5T9N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9N9"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027279">
        <property type="entry name" value="D_amino_pept/lipop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012856">
        <property type="entry name" value="DAP_B_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009622">
        <property type="entry name" value="PRK13128.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07930">
        <property type="entry name" value="DAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50886">
        <property type="entry name" value="D-aminopeptidase, middle and C-terminal domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="9"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="D-aminopeptidase" evidence="4">
        <location>
            <begin position="352"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="538" mass="59502" checksum="1B02FDCBFA86EEAD" modified="2017-04-12" version="1">MSAQNQTIDQVLDAIPLRYRGPGGAAVVVKNGEVIRQRVWGYADQSRRIPVDPSTQFPICSITKQFVCGLMMDLHRDPTSAMAAKGDVRSQFVEKLHELLPMAREKGLTLQNLCDMQSGIRDYWAMTTLWGAKPDDEFLIDRDCPPMLDRTMSLHFEPGTEYSYSNVNFYLLGRIIERVTGEPLGKLLEERILKPAGMTTALLCPNTAHHPPPCVGYEGDENHGFTEAINRMEWSGDAGLVASLNDMIAYEKYLDRLYADPQSWYYTATRPQTFTDGATARYHYGLGHVDVNGIDSIGHGGALRGYRLHRRHVPEEHLSVVVLFNHEADASAAVNDIIQGVLNRPTPETAPVEPAAEWYGVFLDQATQLAITIANSARAGEVLITYGAHLESTPLKLTDAKNGKARSMTGSIDGDILRIHRVSENRKLEARRLTPRETSLKESALPGEYYCAEVDSTFHCTGGAGLLYGCFDGYLGQGIVTPMRYLGDDVWALSCPRGLDAPAPGDWTVVIHRDESGSVVGFKIGCWLARGLDFVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAL1</accession>
    <name>A0A1Q5TAL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAL1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="476" mass="53260" checksum="1EC42EC3921804E9" modified="2017-04-12" version="1">MQPIKSVAVIGAGPAGAIAVDALMQEKAFDLIRVFERQEKAGGCWVSRDDDPPQKFDLDGLAARTADAPLNIPEQLPCWTPVATQDRFTDSPVYPGLETNVDANAMCYSQEPIPTVRSKWSIERHGEDTPFRHHSVIRQYIEDLFTQKGHDGLVQYNTTVERAIKDSTSQKWSLTLRRTEIHNGSPSDYWWTESFNAVVVASGHYAVPYIPAIPGLEEFAARYPGSVEHTKHYRGPQKYQDKKVITVGASVSAADTAVSIIDSAQTPVHAVVRGRYNVYFGDDAFKHPKILRRAPISHITSDDRTVHFEDGTFETRVDNIIFGTGFTWTLPFLPQVQTRNNRVPDLYQHVFYRHDPTLTFVGAVGAGLTFKVFEWQAVAAARVLAGRATLPSAEEQETWETGRIALRGDGPAFTVINPEFKAYFEGLRELAGEPHEGGQGRPLPPFDQKWVDDFNAGHERRKQMWRRANTAATAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAN2</accession>
    <name>A0A1Q5TAN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10047</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAN2"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO97253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="359" mass="39031" checksum="C7EE4FAC1D799CFC" modified="2017-04-12" version="1">MAQTDYKFEGWMGLDPSAAEGNMVWQEFEPKKWEETDVDIKITHCGICGSDLHTLRSGWRPSLYPVCVGHELVGTAVRVGSKVTSGIKVGDRVGVGAQSDSCQGRQGDCEECAMGLEQYCSKKFTGTYNSTHQNGDKSYGGYATYNRVPGHFAIKIPDGISSAAAAPMLCGGVTLYSPLKHNGCGPGKRVGIIGVGGLGHFGVLFAKAMGADKVVAISRKTAKSEDAIKMGADLYIATDDEPDWAKKHARSLDLIVCTVSSTKMPMTDYLGLLRTNGSLVQVGLPEDGTLYAPVRNLMRRLKVESSLVGSPNEIREMFELVVEKKVQPWIEEIPMKHANKAIVDMEDGKARYRYVLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAR9</accession>
    <name>A0A1Q5TAR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAR9"/>
    <dbReference type="OrthoDB" id="3453456at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="188" mass="21102" checksum="49E5A7B252F243C2" modified="2017-04-12" version="1">MKQPTVIPRWWYMIFFVGAIALFIAGGALFGSWYSHASNCANSYFTNVNETWSDYNDCASKKNATYYAALACFVVAVIFKLIAWTLLILHCFQRRRYNQHQFAANYHSVPPMDLNQQPYGAPGPYGAPAPPYYAPPPGNQYSTQYSPHYPPQAPGQATAPMYPDTVYYGPKDANSQPSKDTQTMAHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAS0</accession>
    <name>A0A1Q5TAS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lignostilbene-alpha,beta-dioxygenase isozyme III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10138</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAS0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAS0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="244" mass="27344" checksum="24C0EA819CB42320" modified="2017-04-12" version="1">MDAGFHGHVAGCYENEEGHVVFDLTVADGNVFFFFPPDGQDASTLNARNRLQSITHRWVFDPKTRTGSHVSPEIRWDTSGEFSRIDDRFVTKKYNHFWQARIDPAREYDAAKCGSPAGGLFNCLGHYTWDDKSEDVLWAGPRATFQEPTFIPKNGGGEGEGWIIALLNCLDVLRNDIVIVDAQNLKGGPLAIIHLPLKLRLGLHGNFVDQREIEAWQRRRGLDGEVGPAHPAQKPLAWQLDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBY5</accession>
    <name>A0A1Q5TBY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9674</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBY5"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="403"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO97748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="764" mass="88637" checksum="60D69CA7599C40D9" modified="2017-04-12" version="1">MPPAMPQTPHKDDLEETWSFLEAGINSVMLKLEEGVDMKTYMALYTAVHNFCTSQKAVANNQGLQAHRGAHLLGEELYKLLGEYLSRHLAVVLNESKGHAEEALLGFYIREWTRFTTAAKYVNHLFSYLNRHWVKREIDEGKKNVYDVYTLHLVKWKDDFFENVHAKVMDAVLNLIEKQRNGETIEQSQIKSIVDSFVSLGLDENDSKKSTLEVYRQYFQRPFIDATRTYYENESRQFVAENSVVEYMKKAEARLDEEKARVGLYLHQDVAKTLTETCLDVLVTAHSTLLRDEFQILLDNERQEDLARMYRLLSRIKEGLDPLRSTFENHVRRAGLAAVEKVASEGDSFEPKLYVDALLQVHTRYQNLVDDAFNGESEFVRSLDNACREFVNRNRICKTATTKSPELLARYTDSLLKKGSKAAEESELEEMLVQIMTVFKYIEDKDVFQKFYSKMLAKRLVHVSSVSDDAETSMISKLKEACGFEYTNKLQRMFQDIQISKDLNASYKDWQDKVLDDDDRKRMVDAHYQVLGTGFWPLQPPTSDFTAPIEINRTAERFQKFYFDKHNGRKLTWLWQLCKGEVKANYIKNAKVPYTFQVSTYQMGILLLFNEADTFSYSDIQKATNLVPEILDPNLSIFLKAKVLTSSPEGAKPEPSTTFSLNYNFKNKKIKVNLNIQIKSEQKVETEDTHKTIEEDRKLLLQSAIVRIMKSRKKMKHVQLVNEVIQQVKSRFPPKVQDIKKNIEALMEKDYIERLDGDEISYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC69</accession>
    <name>A0A1Q5TC69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trichodiene oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC69"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC69"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO97821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="412" mass="46860" checksum="0B736B8900DED463" modified="2017-04-12" version="1">MIGAPFSMGATWHHDHHKFRRGLIKNHFSRQSINRISPKIRQKVDKFCDRLEEASKSARPVNMSDAFAALTSDIIAGYAFDLELEFLSDPQFKNDIYRSALELDMLCHVLKFFPFILKPVRWLPSQLTIFLGLQNKSLRSLQDIIDKQIILKSFQADLCEKDENRTTENIFTSLCNPRVPAEERTLDRLRDESLVLLIAGAEATARALAVFAYYAASGSICLNRLRKELREVLPDAKSHASWPQLEHLPYLTPMSSSAYLIHMNPDVFPEPERFSPDRWLKAAASGINLERYLVAFSRGTRQCIGINLAQCQLHFTIAAVAQRFDFDLFDTKLEDIQVTRDYITAFPQDGLFDVKCTIRSSTVEYVREKSKGSRRADGDPIRRGDELDQASGNRSEGTGEKSDEGHPWRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCG3</accession>
    <name>A0A1Q5TCG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-L-rhamnosidase concanavalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCG3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="13410" checksum="334DF3B1BD3BF7B2" modified="2017-04-12" version="1">MDQEQAWLRVGPSSQNKFILDSGQNLVGRLRVRVTGAPGHVVTFQHVEVPENGESTTRPLRHAAANDTLILSGDEIIWEPRYTIYGSQFVEVTNWPSSDDLPKSEDIVARVLHTDTERTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCM4</accession>
    <name>A0A1Q5TCM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCM4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCM4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15437" checksum="65F61CB80478614C" modified="2017-04-12" version="1">MKPSCDDVSTLVASAPKPKLDHADYTIGWICAISTEHVAALAFLDEEHERPEDLPSNNDNDYTLGRIGKHNVVIVVLPVGEYGMAAAASVAKDLSHSFPNVRIGLMVGIGGGAPSRMHDIRLGDIVVSAPGGGHSGVFQYDFGKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCN2</accession>
    <name>A0A1Q5TCN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23597" checksum="39A50815EFC669A3" modified="2017-04-12" version="1">MGLGFGLLYVPTVALISRRFETNRAVALGVATSGAPAGGIIYTVIFNQLISRVGFGWTVRVMGFVMLFLFIGAALLLSSEGGLKSRAVNDRPRILIDMRALKDLPFWSFTVANFLIYLGYITPYYYIPTYAQTRLHTSRSLGSYILMASQGASIVGRVATTVFAHYYGSMVSWVLCGLISGILCLSWISADTLPRFIVFVAFYGTNIPLLFADLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCW9</accession>
    <name>A0A1Q5TCW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCW9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11281" checksum="DF8AEFABAF539687" modified="2017-04-12" version="1">MTPNELRGWLKEEQSQSSGWTGESGETVGHESGRKIVDILEHNPSRKPSDYEDSEIDHMRKVVSYCKRHLAQEETAKQNPDSKSYRSLKNWGHDALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDB3</accession>
    <name>A0A1Q5TDB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDB3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDB3"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="579"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="675" mass="76302" checksum="2901A6694B5D8607" modified="2017-04-12" version="1">MAKKNKKSAEHKERVAAKQSKKTAQKEKKSKVKGKDVDSDAEDADLDAILAQYAEEQAKFLKVTEVPSGPPAPRSSATVLASPSNGNEILLFGGEYFDGTHATFFNNLFVYQINRGEWKEVTSPNSPLPRSGHAWCRGGNSGGVYLFGGEFSSPKQGTFYHYNDFWHLDPATREWTRLETKGKGPPARSGHRMTYYKNYIILFGGFQDTSQQTKYLQDLWIYDCSKYTWFNPALTTASQKPDPRSSFSFLPHETGAVIYGGYSRVKAASGAGGKQGKGGPQKMTLKPMVHQDTWFLRITPPETESAAASTGPAIRWERRKKPANTPNPPRVGTTMAYHKGRGIMFGGVHDVELTEEGIDSEFFDTLFAWTTDRNRFFPLSLRRPRAAGKKQQANQANKSRNRGRADEEELLQNLKALEAKQGLLDDDDDDDFMQLSTPKTEEEPVEPAKPAVVRFEMPHRRFNAQLAVQDDTLFIYGGTFEKGDREFTFNDMYSIDLVKLDGVKELFYVEPENWNLLDEEDSDEEMDDEEDEEDEDMDEEGADAMSLDTSSPAPTETTVPSVTQGMEQLEVEEELDQPVDTRPQPRPFESLREFFSRTSEDWQNILLEALRWKGQAEDKTVKELRKGAFDMAEEKWWDSREEIMALEDEQEAAGIGEVVSMTDRTENMGGAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEH0</accession>
    <name>A0A1Q5TEH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9051</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEH0"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="37413" checksum="66CE7C7EE0F989B6" modified="2017-04-12" version="1">MALSKVVSGAFQTLFDKLPHQVQRFILIPSVRKGLAFLAAWKTLGVINRYISHQAQNNWVRLGPWDPSRELVVLTGGCSGIGRQILEDLTKLNVKVIILDVQEPIFELPSNAYFYRADITSSSVVKEVGNQIRKEHGNPTILINNAGVGFGETVLDAPEEHIRLTMEVNTLSHYWTVKEFLPSMIQKDHGHIITVASIASFAAVGELSAYAGSKAAALAFHESLTQELRHWYKAKKVRTSVIHPFWVRTPLIDGLINAGKHFKAPIMSPRDVSSAVVKQIVSQTGGQVIIPSNHGSASFLRGLPSWMQERVRNKGSKQLVRLRELQREFAAQQATAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF66</accession>
    <name>A0A1Q5TF66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF66"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="290"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="417"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="532" mass="60746" checksum="E8B074D2EE4FBA67" modified="2017-04-12" version="1">MALRLSAEQAERVAEGLTAFRAPLPEHTTEITSLISDFYAISSSLLSLDNLSRDARYRRSWALVHQDVDLLRSSLKYTIDDILEFFNRLDGGHTTPDTYQRTWLSIDRFFWNEAQYSLGTRLAKYKSFLRELVDSVKDPRHESPLLAGSRSSMKMLLVEQEKRLAPRLARMSLGRNPPSTSSTSTDQPSPRNERRPPLRQRSYERSRPPQLSPKAPLSPSSASFSDFPPSVPEVPSSPLGSASATGTSHSTHSDAIDYHWIKDVFSTYETETPIPPGRERAGCFGDPHAGIKPWLREQGFELLLQLAFNDDSNMVVYFYLRERDHRVRIVCKVPHRSRASDYYCLPLNLLEVIREGSCLQLCRRRHGGSELVLWASIQFTTIESMVAFYVAFLALRSQDAGHPVEDIRDYELDGEREIYGGQIIDDEYHHALRVYRDKTTKAVRLQASVHKGDMDHTPVWTAFITSLLSRRSWLRIVDDRTVIIRDLKPIILMATDDYTPPQNNRGEHILKFATLEDADAFLDQMQALAAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFS0</accession>
    <name>A0A1Q5TFS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFS0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="43122" checksum="D998743CF4A55816" modified="2017-04-12" version="1">MAHQAHNIPWSLLASNLHWSTTSRRARSVTNLRPSMKPDQGKELTYFIEAFIRTIDDHSLCERKKYPSVYDVVDSTEVILDSATVQRITPTVRKWRSYGFGGRCPSGICKVAQNKEDCQCIPIPNEERTASAFLRPPGPRDCYRFFNLNREAFFNVEVVKTLLLHGEMDTILRVCALPGVSPPQWWPDSECMCEDAVLGWDQICIKALRAYICLNTIHCFPEIWDNASGRTMEMDYRSSKFYQFTLRTCTGTGQPSEVSTYPHRQFFGISDDQFQGENDYPLFKSAPWLQWADFKHQGTGYHRRRVDHYGKVPINEFLTLENETSAGHQPGTLEVVLVRDYLYRKGLPAELVLNVMELAGYRPATSELHVKIHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG45</accession>
    <name>A0A1Q5TG45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG45"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG45"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06819">
        <property type="entry name" value="PLPDE_III_LS_D-TA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="263"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="367" mass="39927" checksum="FBEDE4BA17FEFC9C" modified="2017-04-12" version="1">METPKVGDKIADIDTPSMIVDLDLMEGNIKKLMDKLLPTGLDIRPHLKTTKSAILATKLAKAGAKGGCVTKVSEAEVIAAAGFDDLHITCPIVGPAKVRRLAELFRKYRQVRIVVDSEIGASAINDALSKSGIEEPILTLIDLDVGLHRTGVKPGEPAMELIKYVGGLKYLKIIGVQGYEGHLQHLHDYEDRKSQCLESMRILTSTAESFRQAGFNIEVVTTGGTGTAEFCASVPGVTELQPGSFIFMDTDYRNAVGTFYSNSLTILSTVVSKQGPRAVTIDAGLKSLTTDSGMAECSDERYKYSEFGDEQGSLVWEEGTPDLDVGDRVMIIPSHIDPTINLHDVYYSYRGGVIEEIWPVDSRGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG79</accession>
    <name>A0A1Q5TG79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049237">
        <property type="entry name" value="DUF2264_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049349">
        <property type="entry name" value="DUF2264_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016624">
        <property type="entry name" value="UCP014753"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35339:SF4">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10022">
        <property type="entry name" value="DUF2264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20938">
        <property type="entry name" value="DUF2264_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014753">
        <property type="entry name" value="UCP014753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2264" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2264" evidence="2">
        <location>
            <begin position="101"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="40458" checksum="7751FDD650291A5E" modified="2017-04-12" version="1">MVGFWGALGFADVELPAPLTWGVVKGILLRNFRWWATQPDIFNNDGTLNLGYCYANSYLTENYNSPGSPYWCCLSFTPLALPETHPFWTSEEEPYPTASLPEVVALKYPKHIAIRRGGHSFLLSSGQACHYPMRATHAKYGKFAYSSSFGYSVPTGGYQLEQYAPDSMLALSEDGEFWHTRRLVEDAHFEEPGQDGVPVLVSTWKPWSDVEIETILIPPATETPNWHLRAHRVRSGRALQSSEGAFAIYGCRSDNGRTLGPMKGDAEEGTISGSGSALVLSSAGAVGIVELYVSGLREGRIVLADPNSNIIHGRTLLPSLNVDLLPGQDQWFVTAVFALPGDTSAWRAGWEKKPMIPGWLAKRMEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGD0</accession>
    <name>A0A1Q5TGD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGD0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="20577" checksum="AB102EDDC3972C69" modified="2017-04-12" version="1">MGGSVSKMMGKIFGTKEMRILMLGLDAAGKTTILYKLKLSNQDVTTIPTVGFNVESVTYKNVKFNVWDVGGQDKIRPLWRHYYSGTQGLIFVVDSSDTARLEEARSELHKIINDREMKDALLLVFANKQDIPGHLSPEEITQQLQLTKLKDKLWYVAPSVATDGTGIFEGLAWLSNNVKTQPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGG3</accession>
    <name>A0A1Q5TGG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sigma-70 region 2 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGG3"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="73997" checksum="CEE0A0FF96AF625F" modified="2017-04-12" version="1">MAASDQGASNAAEDSANTRWQFIDASDNSRSNLTQVKRHVMQEYMRQKKGGSRNSESEEDQSRPTTKRGRPKKTRAAKRRSTKKTAESDQSSSQPKLATKKTTTAKEEDAPADSEEIGPDDISEAIDALVAADIPETTVGLPFRTSPVRSQELLFQSHTFIDRSPQSQGQITDFNSLAAWSSKPTTPFELTRSPRTILSAARTDPFNTLPLELDLEGQKLFDFYVNEMPACSYGSHFRSAKAHNWYIQVFVPEAMKGPVAFQNTILVHAANTWAWVRNETETSNTLIHRDRAITMLREHLHNNPRDNSDVAIISCLSAAALEDFDPRPGHKEISWVHMRAAREMIRSRGGSIAFANTRLGMLINWQDYILSGYETHGPSFFFEQQPPPSTSLSQPPHSSFQPSQHPHCMPSPPESTPSACSDTAPGEPAPAIAPTSIHTSSPIDEIRLQCEEFLDFLRRCEQLALYQKTNPETCDVSRHTAVQQTSLLYQILAAPPGARFTGSGDRKQMVARLSALMMLNAALWDYRYSPIHTGTFLKTLEQALVDSEVSMSGSVEAILQILLECKDGHTDTWPAVPTEQLPDFTQYSSTATSPFARPWFVGRMLKIAKRLSADSWYHVNDFLFSCLTLQVHESSVYRWEADLRREILDAPLTSYIMPSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH80</accession>
    <name>A0A1Q5TH80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8404</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH80"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036524">
        <property type="term" value="F:protein deglycase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017283">
        <property type="entry name" value="HchA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003168">
        <property type="entry name" value="PRK04155.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF20">
        <property type="entry name" value="PROTEIN_NUCLEIC ACID DEGLYCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037798">
        <property type="entry name" value="Chaperone_HchA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="9">
        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="32496" checksum="1C02532FBC2CF739" modified="2017-04-12" version="1">MSSSSDRAPVRDQAEDDAWFPSPYSLSQYTSPKTDFDGANYPNPYKGGKWKVLLIGSQERYLEMAGGEFFSTGNHPVETLLPMYHLDAAGFDIDIATLSGDPVKFEMWAFPQEDKAVKEIYEKYKAKIRKPLNLEDVWGRGFTQQTPYLAVFVPGGHGVLNGIPFSATVGKILRWAHENQRFLISLCHGPVCMLAADIGKPEGSKFIYDGYQIDVFPDSLDQGANIDIGYIPGKMAWHVGERLRKLGVTPLNRSISGETHRDRLVLTGDSPLASNNLGKLAAETLLKEVSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIC8</accession>
    <name>A0A1Q5TIC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIC8"/>
    <dbReference type="OrthoDB" id="4321464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7630" checksum="02570273AA5B05D1" modified="2017-04-12" version="1">MVLDPFTSLSLACAVCQFLDFSGTLFSKSRKIYKSTTGYDDDTDTVLGITKNLRSLTEKLKTPADPYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKH5</accession>
    <name>A0A1Q5TKH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKH5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKH5"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="8">
        <location>
            <begin position="182"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="54132" checksum="7B8D3DE65953F5D5" modified="2017-04-12" version="1">MEASASPGPPKHRIPGLPNPVIAVTQQKWIFSDDELERTPSRIDKIDREKEDYIRHRAVEFIWQVSMMLKMPPQTSMTATVFLHRFLMRYSLRGQYPEVGADLMHPKVIAAVSLFVAFKVDETMRRMKDFVVACCRVAMKQPDLVVDEQSKDYWKWRDLILQNESVMLEFLCFDLQLESPYRILWDYSLFLGVGDNRPLRHSAYAFLNDSTYTVLCLQFQPRVIAAAALYAAARHCQIAFPDDSEGRPWWEQLDVKVDELIRACKLIVIIYERVQQNLSKGYPDFAFSDADPNDPTRLFNNNPIADPVSTPTLSTPGDSAALNGRKRSREPDSQSIEHNQPTQTPTTQPSSSSLNGERSPKRQRTISPHPAAFPTASPSSSTSRPRIPLRALEAVRQSKTTDRLSRENQDQTNTNTNTNAQTSSTQNPQKEETSPEEGEVSDDKGVDPSIVPPESKATDLPLSAPRGNVNDEGGGSEEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKL5</accession>
    <name>A0A1Q5TKL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose/galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7697</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKL5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="42356" checksum="FF8F74A8F0DCC4E3" modified="2017-04-12" version="1">MQQTQFIIGLYKRNITVEDSAITSAVHLTLRQSLLPNALVTILFFLWGFAYGLLDTLNSHFQTTLNISATESSRLQASYFAAYFICPQTISGWIVRKYGFQVTFMTGLAVLAVGCLLFWPSGAKRSFGGFCGSNVVGAGLSTLETEADPFLAICGPPKYSEIRLNLGQAVQGNVQLTHLGVACFVSLLVILFWLAPFPEITDADQEALESQIVEGNQNTGPFKKQYSLLLGVWSQFYYVGAQVAVAGYFINFCKETGKTSAESLLLRYYLHLGSSWPWSPHQAWWIHARGSLSGGMVFPPMTGAVVTRVNAHTAMAIPVMGYILALIFPNYVNIYKKESMDLHRNTEINVKGPSAKELELEEGNYGKPTAANVETIEPQETERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKW7</accession>
    <name>A0A1Q5TKW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6508" checksum="6570D759FC346A6A" modified="2017-04-12" version="1">MADPLSIASGIAGLLSFGIQVTQSLVNFYNTYRDRDSDLAKVTQNLDNLQSSFEPLMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL31</accession>
    <name>A0A1Q5TL31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="60" mass="6794" checksum="CCF502F648B83DF5" modified="2017-04-12" version="1">MAEYVLYIYTPSLTVAIIALLLFLAATVAYIFLGIKHRLKFLIAFIMAAFSKPLAMRLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLB6</accession>
    <name>A0A1Q5TLB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial inner membrane protein OXA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLB6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLB6"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="13">
        <location>
            <begin position="140"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP00987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="497" mass="54729" checksum="4B53AF3B7EA49875" modified="2017-04-12" version="1">MMGAAGLKGPSAATAFARQRLTAVSRSTRSISTFRPQRFQLSGQKSQLTLASSGTASWRRAALAASPVAIRFNSTSSESTPASVPETTTPIDPTDVGFDISEIPEKIGYLKELGLDYGWGPSSMLQYVIEHIHIWTGMPWWASIVSAAILVRIGLFKPTIAASDTGARTHNARPLIDPLRQEMMKARMNGQTHEFQIKKAELDKVQAQHGIKPSKAFIPMLQIPLGYGIFRVVRGMTSLPVPGLLSESALWLNDLTVADQLYLIPVITASCLYFTLKKGGETGTMDILNTSAGKAMLIGLPAISFTFMAFQPGALQLYFLSTGVLGLAQAYIINNANFRNAMGMAIPIRRQAPQDMSNLEQLQTRLAELQANPEKFKKQEPTNDSNISAIDRVQKSISSWSEKAKQEVTDKWSEVRGNSTKNVDGSRAAGPRLSTEDRQSAERYEKEARAREAALREERNHARRSAHMRTLASERQKAQNSLKNLQAVGRDNQARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP28</accession>
    <name>A0A1Q5TP28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP28"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP28"/>
    <dbReference type="OrthoDB" id="4716584at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="606" mass="67972" checksum="A9A3139CBFEC108D" modified="2017-04-12" version="1">MGPRSSATQSHSSTIEPDNDHKETPPSREVARQQEIESTLQKEDTPHPRPRRFLAQPIETSSRSVQTQNASPDDRRSPRSGSLRNEVTNSSEQAEPQSHRADDPPRRFLPQPIETSKASNQGVTGSRPRRFKPELLETDHRSVKGPQVGPSYRRSVNFDPVQGSLELPVERQGPLARLAPNRSASFDVPESRFSYANLLRRHETRRHSFRVPDLPSIPSDESETSDTPCETPWPSSSLGRSSVKPVQSQQEDPWNPESRPSEFSKYLLSLAARSAQKELKEQALAAFPNEQVYQPVDHFAIDEEGGDSGDDDYLVYPQPHHIKSRRQSSADLSWELEYMRQHKEEAEQRLRVMVASNKNLDFSPNHNAATRKYGPSPPMLGADIVLPQSLSPEGTLCEESSSETNVQGQEGPCNDCGGLWCAGAEPDEGRGLGLWMGTCRKDEGFERDPQAMTGIMTPMIQCEEFNFTPSPPLESHADSRDSSRQLPKGTTSCLPRRKLDAEFNDGFVTQIYNYLSLGYPCVARYYDHELSKISGIALEELRRDDLCADAQGYVVAPADSMAVGCVRWKALRLYIHEWARQQPNMVEDELGLEAWGVPERRGSWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP48</accession>
    <name>A0A1Q5TP48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Quinic acid utilization activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP01986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP48"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP48"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000005">
        <property type="entry name" value="Quinic acid utilization activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP01986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="846" mass="92763" checksum="D100F0185838996D" modified="2017-04-12" version="1">MDEGSDKAPRRKRVSRACDRCRSKKDKCDGIRPTCSACQASGQPCSYDPHAKKRGLPEGYVRGLEKLWALSMCNIDGFEDTMLAMLGTTAESAGRREKLMSVWSDDSSSESLHETWKTSRLYSALEKMLSNSEAPLTTGKRSRNPHDDQLEGSDGQWGFRVARDSTPLGPEAPRIVGPAIGSPNAKRARMSQTSNGRDVSQSGTGSHALQLPPQTSQLLDIYFATTHSWFPIVAKHNILRASYLYANAPFSVATTSPGSGDHAALWAILSYTITQSSATTRVNPTGNVSLAKEYYTVSRNLIPLEKERYELGHIQALLLLSLVNIGLEDWTAAWLLSGQAVRMAIAMGLGAFADTRRSDELRQGKAVFLGCFVIDSLLSFRLSRCPAMSSNDLANVGLLEEDGLEEWNSWVDVLPPTGVPHGKNPPRRGPLLSLSCFNRLVELASVLNKTSRNLSMGYKAPNFAQQLVMDLKQWDDGLPLGCRLIGPESIYPERHSALLPHQTYLGLTYVATLLWLYLRLIPGEQGLHRSQRPATEGAKKLLYRGLSMISQHLENFPMCGLPPIFEFGLRTISEQALSLRQTVDSSDTFPFTRWAEEFRQKTTVLISSWPVYGSLVSSMERLQKPNNLPVAPQSYPGNAASLATSMHGVMQPPVVAHGIPPPDQGSYASSILGISIPADGQSLTPKDTVMENTEMAMMDPSVQQPIRPVDKVTPCSGPDQLFAPAQPHTPDSSISNPMMASNAPTSEHSVSTNDHMHFNPAGPGDLDAIFKDLAYLDTTEWSNNREAGLKDFGFLDDSTFQAFCHDPDRLVGSQPLVHPPSIADIWPPPGFFPETFQEVPEKAMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP74</accession>
    <name>A0A1Q5TP74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP02002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32945" checksum="D605C586DB9A9161" modified="2017-04-12" version="1">MSQHHILVQPTTQQVVARPEDDWTGKSDPKERKKLQDRINQRILRQRKRAGYWQRECVLHTSRVSANAEMVPYEPPGEQNVPWPQSGSHLAICSCKPKFMDISSFTACKPDSELTENFIRHFSTWVHGEYLRGSPRTETLLSLVQFNITRALVTNAKTLGLTTRRMSRQARSRFASTGVEATFIESLPPSLQPTIFQLTIPHHPWIDLLPVPELRNNLLRRSSDSYDAAQLCRDMRGFQQVAHGRGGVTVWGQSWDPHGWEVSPDFAQKWPWVVQGCQSLLESTNHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ32</accession>
    <name>A0A1Q5TQ32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ32"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ32"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF23">
        <property type="entry name" value="DEPENDENT KINASE INHIBITOR PHO81, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="440"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="730"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117189" checksum="0C415E19035FC955" modified="2017-04-12" version="1">MGTQWGHNGDTIWHDRKFGKQIQRRQLDLPEYAASFVNYKALKKLIKQLSATPTIPAQRTAEEIAQDGTLDPQAALRANKEVFFFRLEREIEKVNAFYLQKESEFSLRLKTLVDKKRVIQSRTVSNSKAPSNFVALFEGFQQFDGDLNKLQQFVEINETAMSKILKKWDKTSKSRMKELYLHRAVEVQPCFNREVLRDLSDRATTARLELEAWAEGENLQFDTSRPTERAGAPFGTEEEELDLQVLQSASTGNLQTLREWIAKLLSFPDSRDRATRTFLNAINGFADDVLGLLLESGLVDIHAEDDINERNCLHEAAISGRDFVFKAGLTAGVDFSRSDVYGRIPLHYACMHGRVDMVRELLAAGPQMVDVMDHDNFTPLIHSIVKNQLSCAEQVLHSNARIDPASESDHIPLNLACQHGSLPIVKMLLERKARLLPDAEGLYPQHMVARASQSPDLLLLLKQHGADLDQRDKLYQWTPLFHAASEGCVPCLRTLLELGVDAKVNDEKGLSAMYYAAWEGHLECMLLLWAQPSQSRRPSQRPLDLLNGVSFHEPGMMEDSGAMRRASSADMDIADGIPDLELPPPIIPLRRYGHNFLDKKVFVQLLFDQGNLGSIAFDQAGRHPAARLTISSKLSDLIPRTIVLPIQDDSRTISFHVDNLDTFAVDFEIFPTFGSKVIAKSVALPVVFGAEKSSTGSCCLPLFDPRLRAIGQLRFNFQVIKPYHGDPLEITHFATYWKATSAVDSEHNGLVTGSSLSGDYVQLFVQLTRDRVPVLYPQFMINHHGIDIPVCHLSYAQFQSLGAERGVNQQEILQYLGTQAVNDMPQTHRLLAGSFMSLREVLRQLPIDLNVNLSILYPSGAEEKSLDLTALADVNSFADAILTDVFDHARVARENSPDFMRSIVFTSYNLNICTALNWKQPNYPVLLCNDLGQIRDLAGDVDALPLVNSSGRASMSIKESARIAQSNNFMGLICRSSLLNVVPALVETIKELGLVLVADTCDETGQPDRADALTSANAMGVAEWAYRMPDGVNGVMKANGVLRFNDMIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRR1</accession>
    <name>A0A1Q5TRR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRR1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP02909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="9283" checksum="7B4B5211A8F80508" modified="2017-04-12" version="1">MADETTDSKPLSETLPDAPEATPAKQSVHSFKYDILTALGETKKYAKLKMKFTKQELESEALIREELRIEDLSKRIQEQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT06</accession>
    <name>A0A1Q5TT06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT06"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="70" mass="7477" checksum="85571F8D697136CE" modified="2017-04-12" version="1">MDDFFSLYGDESNYSIEPRGLAVTHDGVAIGVHATGLFARTPEITSLLAGNPGNPSEDWGQSYSESNNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U047</accession>
    <name>A0A1Q5U047_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U047"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U047"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP05847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="405" mass="45967" checksum="2C96AA080BF9F9C9" modified="2017-04-12" version="1">MQTYSDRFRVYRKAMQPYLGSETAIAQYNSLQEIEVHRFLLRVLLRFLQDPSKLSQHVQTEAGAVILKIAYGYSIEQHTRDPLVDMANLALERFSLAGTPVVWLVDMVPIREFYLHSTYDEDLDIDSHFYRQEWKKQLENVVDKPYAFVQRRMNSGKFQPSYLSNLFKASGYPLVGSEEEIIAKWTAGSLYTGGADTTVSSIETFFLAMTLFPGVQRKAQEEIDQVLGGRLPTVADRGKLPYADAIVKEALRWHPVAPMGIPHVSVEDDLLNGFYIPKGSLIMPNIWALTHDSEVYHDPMVFKPERFLGIDGREPEMDPHAVVFGFGRRVCPVSNVDKACEDGKEVEVKPEFQAGVISHPVPWKFNVTTRSPAHEALILTVEKEHPWEESDAPDLENVSDHSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Q9</accession>
    <name>A0A1Q5U1Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of V-ATPase in vacuolar membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U1Q9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="596"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1335" mass="150602" checksum="ECC2397F21DC5A33" modified="2017-04-12" version="1">MRAVLPGRPPAKLQSFSTALWDGLRVIAYISGHALVILGGPQTLLQTIYVDDTEKLEAVVFDEASGKIAVCGGPDIFIYQPYGIQGETLKWSLACTFRAKDDDESIHTLSWGSPNELLVGNSRLALWMLNDTPRLVWKRKLANPVKFAQFSPDGALVVTVGHYDRLVKVWRRLAFGEDEVRFEVSYLPHPDVVTGVHWRLPYHREQSVDNVLYTLCADNKIRVWAVTDHHALSPLQLWADIDMELSLQPRDASSIDQGPQRRYGFFLDGRDFCSATERAVERNTGNKENHALEHIIEVARQSPEICVVIDGQGHMSAWALEDVGSKVKTKMSVFNILHVEGLEFGFMPGLSAAEDYAQIRAFQSNTTEDNLSIVVHHFDGRIEWYDSQVDVLFDPTPRKNRISPKSSWSGHTAPVKKIVRNAIGDTLISRTDENKAMIWRQRKRKSGSMLLHKSILLSDEHIHRTCLIEDSSLLVNLHHNGISLWDFNSYHAKRIAHLSFTLSSKPLCVLPLPTPDTKSRVAYVATIGADMNGIAWEIKWSTSEGCQMRKFCAFEMGLKEDLAYILPVDPAGPKAKHSGFFDTFSPDIALSYTHSGVVRTWTAKVDQANAKVEWLLKSTVDTGITNPSLASGSTIRKAALVDENRTHLTIWDTNNAQLEFEEHFAQHDIIRDLDWTSTPDMQSILAVGFPHKVVLLSQLRYDYLDAQPSWTQIREIWIRDLTPHPIGDSCWLTNGHLVIGAGNQLFVYDKDIDIGDRLVSGLRIPSRGLSSVDLFDVVSRLNGPLPVFHPQFLAQCILSGKTSLVHSILINLHKKLKFYTEGDDLDGFLEMPLQNFYEDSDVSQQAASKEMRSSYTDVTVQEEESFVMDENTAAVLNENLARIALPQITSHEQFRLVDTIECVATVEKHRRSMDDNAARYLLFFRQHMLRRSQGVANKDTVSWREIVWAFHSGSQDILTDLVSRQFNGKLTWKAARESGIFMWLSDLTALKVQLEVVARNEYGKTDERNPTDCTIYYLALGKKNILQGLWRIAHWHREQAATQRLLANNFSEARWKTSALKNAYALLGKRRFEYAASFFLLADHLRDATNVITNQMGDLQLAIAVARAYEGDNGPVLREILQEKVLPDAASEGNRWMASWAFWMLGRRDMAVRSLISPIESLLAPTPASPGSPGRVTLQSKSYLSNDPALVVLYQQLREKTLQTLKGASQVRPREEWEFVLRNARLYDRMGCDLLALDLVRHWEFLGGPPTPRTLQTQPALDFHDGGVDYRKMLRRRSSLVVADLPVRLAEAAKVSADAKDSSAVEDSHKQAKPKPPPTMFHEPDANSLLDSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1U7</accession>
    <name>A0A1Q5U1U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1U7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1U7"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP06411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="370" mass="40833" checksum="0FBBC4FAAEF7B005" modified="2017-04-12" version="1">MAISDEHGSQGPTVVGICLAFAVLTFVVLSLRLFARIYVLGKMGLDDYLIIGACCLAWAFIGATIVAVNNGLGEHYEWTDKTKLVDYSFAVWLSSMFYLACLGFVKTSVLWFYTRLGDRTLTRISYVMMAVIVSQAFSFVLVAGFQCQPISKAWAGGPGKCVQINIFYLANAALNILTDLLTYTLPIRVIFKLQMPQKQKIALIFILCLGLFACVSSIIRITYIPSMLTSADYTYAISGAMYWSVIETNIAIFAASIPSFKAIASRFIPRFIGEYSNSGRKYAWSSTPDARRYGSGFTKVTDPKNLTMNGREDIAMGTQIGATMADNSSEERIIVPDGKIFAHTEIETTVESNTEYRSSMEQAHRPKGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3A0</accession>
    <name>A0A1Q5U3A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxynicotinate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3A0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3A0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="50452" checksum="5542FEB75AB2A8DB" modified="2017-04-12" version="1">MDLPSPPRDIAIVGAGIAGIACALALSRELTPFVPNLNITIYERHDILSTSGGAINLTPVAQRHLAKLGVLDELDRMGSEGGAEVDAIELFSMRSGRSIGSIDFVDHNGNGFGGYKGRRVMRIILSVAMMTVVERTPNVKIVFGKKVIGGEEISDKAVIHFSDESEVIADLVIGCDGVHSPVRTRWVDPDRASQYTGMSFLQATIPANTLSTPPHFQSSALNISRHGSMLTSFCDRDREQIFVAAIVQFDQANLSYHRLEPGQDWATKDRIRRDLRCEMRDRFSKSALPCIREMVASKEDWMLYPVYQVRPGGRWCMNRVILLGDAAHAMPPRDESAAYALDDAILFARILARYRQEPLTEVFDAYERLRRETINHAFKESRRMWDRNRDMGFLEGRLKEWTMPFHIRSHRDERESAWEFDATKILLPTPTPSEDLVSLNSFLKEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3T3</accession>
    <name>A0A1Q5U3T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3T3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="52" mass="6067" checksum="3D11A73055E24A37" modified="2017-04-12" version="1">MADPTKSPEDPLQCRFLFESLENSRWEDMMSAIESGIFSKFRGSHEAPHYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4M3</accession>
    <name>A0A1Q5U4M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4M3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4M3"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13620" checksum="CB33D375D3BB6152" modified="2017-04-12" version="1">MASFRHGQKQSEHHDNGNHPEGENNRLLPLGLALVELSLGKPVRTLLNPGDDEGEDILVTKVRTVSRLVRMVYMESGTNYAEALNNCLSWSGPCLEKNFEEKVFKNMVSPLLKDLVNFEGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U721</accession>
    <name>A0A1Q5U721_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U721"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U721"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP08257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44519" checksum="81B4DF4F03D74791" modified="2017-04-12" version="1">MALTVALDLSLNKIVTPSSSLEKESLGRLARADCIDAKRALHMDGFDDVNPNSEWGRRLLRRRERTWIALFVVERGVCLARGRSYTVPPTALIENCDAWHRSDIADRRDGPMNSMAVLRRDLDELFRKVKSSCDSYRIVDTGSEAAQAIKTTIESFYERWFATWALAISEGGPRSLPPYVEILVTHTQLSTYGGVINHPTAPVEVKRFFRAAGLSSALNVLRAAIQGESRLKSMPNNTVIMISFAACSALSLSVTPGDSRSSLAPSVRTLIEETAGVLERIGATPSHRNGASVLYGRFLRELIRRGPAMSNSHPRPDTRSLDLPDPVIPNTCLSEQGPSLTATQPVLPPGDLWTEPMQFSAMSDDQIIDAVNRAGSAFGASIPDVPVDDMLSWDWLDFASTDFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U749</accession>
    <name>A0A1Q5U749_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U749"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19897" checksum="B11C7093D5062578" modified="2017-04-12" version="1">MDTPVRRVITAHDSKGKAYFASDETLIPYDPTTAPEFTTPGPDSGFGVVQIHRSRGFPADNMRDLPDPNRTLVPLADTKGPSCRILDLPPAENGWMHRTLSLDYAVILSGTVGLITDDGVEKVLKPHDVVVCRGTNHEWVNRGTDVARLFVVVVPAKEIVTEDGERLEKTPAGPIFDPAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U798</accession>
    <name>A0A1Q5U798_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U798"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP08361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="40604" checksum="19C9CBBEC628EB19" modified="2017-04-12" version="1">MASSPRQPSLDAEDSNPKALVTSTNIEDFFLPVILCLHDSGSSATIFQSQLRHMEQELGNRFRFVYVNGPFPSNPDPKVRLAFESTGSFYSWVKDMPSSGSEKEDLPQEEIDSIDRVLNQAMMFEGRPDRIWGILGLGQGARLAAGLICREGDRLETGEKFRALKNLQFGIIISGAWPPIMLTEQKKGWIDVLGLQQLPTLYVWGRHAPDHKSYMKMVSKCDWLHTYTHELEGPQYLPVTEKETEQIARRIINLALVPIIWVCVIPFRFLSTPDYGVAKLAPLTGGVLSELRNAVVLVLDTRDFGVADIWSVLTKAQLISVWSVYSCGPGPAAAQRGTHLNIMLGVAVTDTAVVVERLLTARVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9T7</accession>
    <name>A0A1Q5U9T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9T7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9T7"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000003">
        <property type="entry name" value="Proline racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="43041" checksum="AD82EB3FF9FC29D0" modified="2017-04-12" version="1">MDLAQKFENGSAGEAIKCIDMHTTGEPTRIIYSGFPRLQGTLLEQRDQAMNQYDHIRKRIMLEPRGHYDMYGAILTPETELVQQGQAHIGTLFTHNGGFSTMCGHATIALGRFLVDTHDLTVFPKRNELEFNPTTCELAVNIHAPCGLVRVTVPTTANGQESDPSRPVSFLSTPAFAAGIDLEIPIPKEVRWPELGDRESIKLDISYGGAYYALVDVHELGFSSLKQFDLGAISNAASKLKAYLMTHPAVSSALQHPEDSRLSFLYSVMVVDRDVGSRPERVEGTETGLCFFADDEIDRSPTGSCVTARMALAHAKKQRSVGQKWAYNSIVSNRFGTGAFVASIVDDNVSVGGSKEAVTVRVEGKAYYTGTSNFILEEGDLTSTSGFTLKECAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9W4</accession>
    <name>A0A1Q5U9W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_5358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9W4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9W4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="898"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="928"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP09272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118824" checksum="136382F702D3EF87" modified="2017-04-12" version="1">MAWMPQPDASEIPSRPPLTSQQSNSLPSTPYQHARNLSFHSRSPSPARGSTSPRSTHSESTHLPPSARKPLGGCKYETAMAYFRRRIPYSLGVDLLPEEKDGLKESLDSEEERRLTTDIMELYDRLLPSAESDDRRRQLVRKLEKLFNEQWPGHEIKANVFGSSGNKLCSSDSDDGMERVVCVSHAKVPIVKIWDPELKLACDMNVNNTLALENTRMIRTYVEVDERVRPLAMCVKYWTKRRILNDAALGGTLSSYTWICLIINFLQTRNPPVLPSLQARPHKKRATPDGLVYSFDDDLETLSQFGRKNKQTVGELFFEFFRYYGHEIDYEKNVISVREGKLVSKEGKGWHLSVNNRLCVEEPFNTSRNLGNTADDTSFRGLHMELRRAFKYASDGDLTGCCAQFEFPPEEERTWERPPPQPRPIITPSLPSRGGRGGRGGRYGNQYSRGGFANGGRRTSNTGNKSAFRQPNGANATDLSLQAQQQAQFLLHDQLFQQIQLLQAQEQELRMQLHNQALITGRPPPVFLRQPFIQFPMPQQQEYTSEETSRSRSGTVNQPPLTPSGRQQNFYPSPTYASVSAAGTQGSTTNPPSPSATNAHPDLRRNPRRSSVVNGSPKANLRAQSQPARPQNSTSLPTFTPLYSIPQPLDTSFASKQQSIPEPSEGGEGSGDENAMPPNSLPSNDSRSDSVDESRAREMMGYYITPQQMQLYQQSAMLPPLSTPMGLALPNGYTSYLPMQQDYRSGSFSSEGMSARADQTPTPVLRASGSGQQRSTSRPAPAIDRGPLIVDGSVPPSEPRPQYPMDLIDPYNAVTHYTSTSDDHSINTPASFSDSLSQDFQDPGPFEMEQPPVFTRMPFEAPKTGNVNGHDVPSEKTNGQPELLASRLQNLHLSNAEKLAQSQTTSKANPDRQKNGSMHPGSGKDVAQTKNSVSSGDKASGLNQVHEPRQQTSNSKRGRPNGVDASEKANGVNHGNGNGHGHSNGHAHGHHSHKPKARGRQDGTNNSSNPSADRNHDHAPRKPGSAVNGTNDVNHSGWQTTGKKKHRRSAKSSAAESRNGVNGSAEPLPADESLRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAQ4</accession>
    <name>A0A1Q5UAQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000500">
        <property type="protein sequence ID" value="OKP09553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UAQ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="255"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="559"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1446"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1928" mass="215160" checksum="BA38B565EF3B7775" modified="2017-04-12" version="1" fragment="single">LGIIPSTRSTLSHMLSSTTQGPFCTGCARPWLSTQFVTCDGCRRKAARWKVKARQRAAAAVEESRLSTMPPSRPLLRRLAPVLQAPLTSRESSDISNAVLQPAPRRLDPSTERSLVSQPPQAAGVKRCIPASLRATIKKQRTLDPRTFQDTLNQALGFLRDEVDARSAASNAFPPEVSSSHVRTSIARYEEEISAAANRDVCCSCGKLVPKSNIYNVHDMDPLLLPLRGALDTCGRHDNTWDLCSSCHASLNRNIIPKFSARNMVNVTMCQNYPPALKDLTLSEEYLIAKCHPLGVVLKLRPGGRSSPVNYHALRGHFIVIPQDPGPLLDILPGPDLTLHSLIKVFWLGARPPVDSDLSPFLAVRKAKVLAALQYLVQHNHLYHNITVNYRMIDDWSDDFIPPELRDNIICLDELDHHEREGYTVSLRQGNYENDLQAAQDSALDSNGGGPHITGSIFTDINGERQDPNVCALDALVSVVTNRPPPSREVMSARESERNTQLLDHRKIPVVSYTIRGEATLMDHWTDPHYFTAAFPTLFPAGIGGHLDERTIPVSLAAFADWALRHHSRRFARHKTFMYLLYDVIQLRKSSMGNGFLVKRQNWQSTMNDIASLTVNQLQDAAKTAAAGQKIEDLIIRRLLRNIETIGMQVPGSFAQKLRMRSEIRGLIARYGMPAFWITINPSDLRNPLVLILAGVEYSGVNLATANAAIREAAATSNPVAVAEFFNHVCKAILDGLFATNTGQTGILGDLSNHFAVVETNGRGMLHLHGLAWARGNLAFTTLRDRLLQDSDFAARMIRYLESIITQGVDESILHDPEVNLPSISPSATDNESDNDFHLRLSIDSNCVARKMQVHSKNHLATCFKYRKTASGKNACRFGMPRDLVPTSYIDKFGLIHLARNHAWINPWNPAIASCVRSNQDISWIPTVSKSLSLIYYITNYATKDDVSPWQIVAKAALLRHSIEKARKADPPTATDLRLREKGMGNFALRCFNTLSHDREISGVQVASVLLQLPTYYTVNYSFTRINLWWLRRYVRAIIRSDNLDRSRSSDSIAEEPCAYETGDTAPVSIFDNYKWRGPHLASLALFEYCMLVKTKNIRDAIADDADFDPSHPRYTTHVQRLARSPSQVATVTFSGQLTEFQAAEDAVLGGHPKTTAIINDMSEILLGLFVPWTHLVNLFRRYATQRDTCIQVWTAVEPTLPFHIRAFARNIELLRKSKEDCQADAKLWKSANGAADSFHHDVDELEPATFGSDSDDAEGSFRLQDETFNAETLIAAYHSITKAWHRESLVAGRRIPPLLRATTPTRNLDLQNLQPLDIPRTLAYETSGLQFVPPSTLQEWESRLKGFANLDREDTTEREVATSSLTLDDFDVQVEDNIFQPALTSFDMFPDIDDHQSRVGENPTGASLTSLVIEVIPLNQKQHLIVESVLSEALTWADHPYDSSQRKQTLLYVGGEGGTGKSQIVKAIEAGMSLVGRKHEVILMAPTGAAADNIGGNTYHTSLGISIDRSRATAMSSRVRRLWSRKTIMFVDEVSMMDLTMIGVIDNHCKIAKSLDRSSTDLFGGLPVVIFIGDFFQFPPVRGPALWKEPRTGAGAEENGRLLWHHFKQVIILDEQMRQSEDAPFRDLLSRARAGTLTEADRAVLNSKTITSLASPQLQDATTIVKLNSLRHQVNRVRIEQFARARCQNVYIFPALHSRTRSTGPINLRLRADDLLQQPDQGTKVPFPGLFLYTPNMPAVILTNICTLLGLVNGAAGTAVGIVVDQTAEFFQIDDLYIMCTKPPACILFKPDRPKPTAFQDLEPSILPVFPLERSITLKGYSVRRKQVPMCPAYCLTDYKVQGSTLVAAILDLKDDPTIRGQDRHRKYCSTYVQLSRLRSSKGLHLLQEVDMEDLRFGPDPRLLTEMQRLQALEKTTIAAWQEALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAX9</accession>
    <name>A0A1Q5UAX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aly/REF export factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAX9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="36502" checksum="B142DFDFDD69455D" modified="2017-04-12" version="1">MDRSLDEIIAEDSSRKQTRPSGGRRNPPQNRRRNDRDGPYSQDRVDLNLDWVHDKFDDDRDARGSRGTRHRRSGSPDRGRALTKVRVENLHYDITEPDLEDLFGRIGPVSALSLVYDRAGRSEGVAYVTYERLRDAHESLREFDGANAKGQPIRLTLVPGRRERNPDDRNTLFDRVERPERDSRSLSPTGEEGADGSRRRGRRSDTSKPAPDGIDRYTPGSRQRSPRRGGGGRRGGRDGRDGRDGRDGRDNRSRTERGGRRGADGRPRKTQEELDQEMEDYWGGNNAATETAEKQPEAAAAQPQAAPAPAAAAAAPAVADDDIDMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCE0</accession>
    <name>A0A1Q5UCE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000390">
        <property type="protein sequence ID" value="OKP10142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCE0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="6960" checksum="2A7E84F19FB359C0" modified="2017-04-12" version="1">MNVLQLNCLWQPSLLSLVQQDKQEVTQVADELDLDSPICTTPDDFKSFKVGLDTPIQGGRGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCS9</accession>
    <name>A0A1Q5UCS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000366">
        <property type="protein sequence ID" value="OKP10296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCS9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCS9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="210" mass="24060" checksum="BF8A89853DC6327E" modified="2017-04-12" version="1">MADRRVPASGDLRNVVRTVADLPSQFEKSITLTINDRNSTVVARNLILLLLALDTADQHWSEIDQDREVTKTLIHIWYSSFINSRTLSRIQAKALPLIAGVCDEALFLEPGAFLSKTWYFKSQRSLQVTLNREEWLLARRLCCVPGSLTFEQAQKIRTAVTLAPERADYMDRWLYKELTPALRVGQERFREDGMLLPFGHTRNGFNIPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCU2</accession>
    <name>A0A1Q5UCU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000366">
        <property type="protein sequence ID" value="OKP10292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCU2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCU2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="26643" checksum="A2AB255633B11A5B" modified="2017-04-12" version="1">MSGPETAFVVDLISRTISKIEVIKTVYDAAKDAQGQPEAFRQVAARLPLVIRMLHSAKERAQVLDETAQEALEPTLGSYKAKVEALQKIFQKVVRKDDDKWYDRYKKTVVGTLGKQGSVEGLMEGILKDIHVLVCGKLIGTATDAEVQEIKEAMKQMKDMPSSLTTATAVSLTNRSADALQQHSGSGDNILVTGGSVLSLHKGIGNRYVISGDDYHVEGPNPKGAVLAGRFLMGDAKVGAYGYDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCU9</accession>
    <name>A0A1Q5UCU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hAT-like transposase RNase-H fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000359">
        <property type="protein sequence ID" value="OKP10318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCU9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11658" checksum="0A61943524B9050C" modified="2017-04-12" version="1">MRTALEYATQKLRDYYAETDKAHGDLYVIATIMAPQNKLDYFSGKDWKGPYREQYRESLEKYLELYKQRHLETQPASHKVSSIEQFFVVDQMGDRQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDM9</accession>
    <name>A0A1Q5UDM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDM9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDM9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF3">
        <property type="entry name" value="TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="86993" checksum="D35F16D0CA86DF90" modified="2017-04-12" version="1">MADDTTTLKGTDYAYNLGLFERRVTTNSPEAQVWFNRGLIWGYAFNHNEASTCFERAIAHDESFAMAYWGLAWTSGPNYNQPWEAFGPNLENVVQRTYRASRKAMALVDGTTPVERALITAIQARYQSDKPAPMEQYKIQNQAFSDAMEVVYRDFGDDDLDVATLYADSLVTLTPWKLWDLVTGEPIPGTRSIDAKKVLEKALKHKGAKGHPGLLHTYIHLIEMSSTPELGLSPSDHLRYLVPDSGHLCHMPSHLDVLVGDYRAAIQSSQLATRADEKFMQQHGVMNFYTVYRMHNYHTLIYAAMFAGQKAVALDGTDRMENSLPKEVLTTLGMADYAEVFISVRWHVMVRFGMWQEIIERALPDDPVVYSVTTAMALYAKGVAYAATGRVPEAETHRALFIEAAKRIPDTRLDFPNKCIDIVPVASAMLDGEIEYRRGNYTEAFAHLRRSVELDDGLEYSEPWNWMQPARHALAALLLEQNQVEEAAAVYRADLGLDNSVIRARQHLNNVWALQGYHECLVRLGREDEARSIWPQLKVAVALADVPVTSSCFCRTDTENAPKCLTRSRECSYQPSRRGGPRRGIRYAELQQQHRLSSDDQGLPVPSSPSEIDNSFEPLLDNMLGLVTPLAGVHNLDISPDALSDTSGTRQLWGQLTPSADDPFSSVSIPEAEPSAVRSYRSEDDITHSKQPWALLIKAQQTLYASNQMVQRIERITNETPPPDLGTQIKNLDTVISTLMTKSDQYLRYTFDEDGEGLIAENMWRISRIVIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDY9</accession>
    <name>A0A1Q5UDY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxynicotinate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDY9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="324"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="444" mass="49130" checksum="1394ADD7B0B4B0AB" modified="2017-04-12" version="1">MASRRPEDAVLWSVKWNNTNDFALNALKAIIIGAGPAGLAAALRLHQQTNIQVTIYELRAEPTTLGGAVGILPNGLRLLHRLGVYQKIATRGFTSSNLTLHSMQGHIVFQQDFVGWARERTGFGYMRIKRTDLVNVLLEAVQEAKIPIRFNKRLTTIEESDTGVQVTFEDGSSDTADMLFGCDGIHSFVRRTYVDPMKTLEYSGMSGLGSIIPTSVLSPTTTAQITGLDTTLTEDGMLAVNPCTAGKDEMFCFFSKEVTLPESGDSRDGWEVHRKEEVDGFKSTMLESLESAQGEWGAALREVLNNMSSVNFYPVYRLPPGGVWSKGRCLLVGDAAHAMSPHAGQGVSMALEDVFLLSRLLEDPKQPLDKVFDIYDRIRRPRINEIFKLAAQNAGVRRKTGPWGLWLKEVQFSMAMILSSVFGADKRELRQGHLVYDIDEVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE77</accession>
    <name>A0A1Q5UE77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000312">
        <property type="protein sequence ID" value="OKP10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE77"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6756" checksum="318A229114BEDDEC" modified="2017-04-12" version="1" fragment="single">VKPQSQDSILRPRDANRSIKERKEKAYGFKPSQLSDETIQRAKDSAKEAKDKGELFFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEW2</accession>
    <name>A0A1Q5UEW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEW2"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="32382" checksum="B3C75CC9EE5F80AF" modified="2017-04-12" version="1">MSPENSLQQTAERSALEQAYYRKLVDGSHILHYHNVLDAYGHLSFRHPYKTGVFVMSRSVAPGSISAAGDLISYRIEDAEPLDQGAAKGYAERMIHSEIYKRHPHVGAVVHSHSEAVVPFSISQVPLKACYHMAPWLGTRSNGPDSAAPPVFDVTDYLRPSDVPDMLVKSPHLGLALAKCFDGGNAVTLMRGHGMTIVAPNIESAVLRAIYTQKNASIQTTALLMQAAYFGSGTTTRVARDIGAAEVNATTTGEGIDLHYLSAEESAAATEATIWSVQRPWDLWRKEVEACGLYSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF52</accession>
    <name>A0A1Q5UF52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF52"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000022">
        <property type="entry name" value="NADP-dependent alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="36558" checksum="8CA66AA854DCBEB8" modified="2017-04-12" version="1">MPIEFTVFKGSKDGTIVQGTTERPDLKRDDVLIRITHSGVCFTDVHYRNADMALGHEGTGVVEATGPDAHILKKGDRVGWGYEHDCCGHCRHCLTGWETMCAERKMYAYADLDQGSFGTHAVWREAFLFKIPDNISNEDAGPLMCGGSTVFNALHVAQVRSTARVGIVGVGGLGHLAIQFAAKMGCQVVVFSGTDSKKEEALKLGAKEFYATKGSKELKLEQPIDNLIVTTSSQPNWELYLSVMSPNGVISPLSVDENELKIPYMPVLLNGLRIQGGIVSARQVHRDMLDFAAMHNIKPINMTFPMTLEGVKQSLKTLEEGKMRYRGVLVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFF4</accession>
    <name>A0A1Q5UFF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="268" mass="28695" checksum="B59FEA684FD19C25" modified="2017-04-12" version="1">MGIAVAPADTRPIIGGMSGGYIAGTKGLAWIHWVNVILSAILLLACAILVPETLFDRTKALPSSQNQDLISSEGKPDAEIVENVTSTSPDDSLNRQTIYDSMLKMRKYEGNFLEKFLAPWKTLRLPGVWLVMFWYAGLVGGVVTITTVGPSLVAAPPYLWGNNAGLIMTGGIVGAILGLIATNLCADRVIIKRSKLQGNSFVEPEARLPIAIPGLFLATTGLWTFGFCAQNLGPAHMWVGMQFGLGMLCFGLMQAPSIGFNYVSGSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFR4</accession>
    <name>A0A1Q5UFR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFR4"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000633">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000867">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit Utp15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="394"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="542" mass="60354" checksum="7FF3444E2CDBCECB" modified="2017-04-12" version="1">MAAPVLPLQQVKLASLPSTRLTPEQQYWRTFKNPLLIPSPANGPVNLITQPSAPSSSAAFHSLTQPPDVFTVTTGARVQIYSIRTRKLLRTITRFDDTVRGTDVRPDGRIFVAGDDTGKLQVFDVNSRAILKTWTDHKQPVWVSKFSPSDPTALLSASDDRTVRLWDLSSDSSARTFVGHTDYVRSGSYMPGSMSSSGLLVSGSYDRTVRIWDPRVEGRAAMTFKMAAPIETVLPMPAGTTVLAAADNKIGVLDIVAGKPLHIIQSHQKTVTSLALASNGERLISGALDGHMKVFETTGWNPVSGSKYPSPILSLKVITSGIAYEDRHIAVGMQSGLLSIKTRLSGQQKVKERERQKEMQALLEGKLEEHDRQVAKKQKLRGSGWEKRLRGRDFIGEGVDIVIEGQDRKKRKKEQPWENDLRKGRYSVALDQVLSSTDKTAQLTLFTALRHRSALRSSLKDRDEVTLQPVLHWIYKHIREPRLVDLCVEVAMNVLDIYSGNLGQSAQIDKQVERLHKRVRDEVEMAQHACQTKGMLDMLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG23</accession>
    <name>A0A1Q5UG23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ER-derived vesicles protein ERV14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="144" mass="16828" checksum="B097565C28DAAFD1" modified="2017-04-12" version="1">MSGEAWLYLLSVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNAYIIPEAAVHAFLTFLFVINGYWLAIFLNLPLLAFNAKKIYDNQHLLDATEIFRKLNVHKKHDRRPHPRRRPLTSRKGGTCHAPWPFQLAPGRRYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG50</accession>
    <name>A0A1Q5UG50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG50"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="306"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="531"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="897"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="965" mass="101420" checksum="73841AACF442F111" modified="2017-04-12" version="1">MVQAPVWAIKIGCFYGLITCDTRPGVWPDHKPQVISWEPPRPSQSHTTTAAIHTTTTTAHTTTAHTTTAPVITAPTTTAHTTTTSIVGGSTTTTSLSITVTLSTSSPLSSGTSGIVSSVETVSPTSTSFPSTFATSTSASSSSSSPVNSPSSTPGSSATSTSAPAGGSLSSTPASSPIASSSPAGSSTVDSSSAPGSSSAPASSSLVSSTPVSSTPVSSTPVSSTPVSSSAPASSSTPVSSSTPVSSSVPASSTPVSSSTPIQSSTPLSSSTPVSSSTPVISPTMSSTAVSLSASASATAISHATVAANILVIARDTASAGVASSGLNAYGIPFTTLIVPQAGVALPALNTSTGGNFGGIVVASEVSYDYGASGFQSALTTDQWNQLYAYQLSFGVRMVQYDVYPGPNYGTTAVGGCCNTGVEQLISFSDISDFPTSGLRTGAGVSTEGLWHYPATISNTTSTKQIASFAANSVFSTDNTAAVINNFDGREQMAFFIGFDTTWSATSNYLQHAWITWITRGLYAGYRRVNLNTQIDDMFLESDIYYPSGTTFRIRNEDMDNIRDWVKTINAKMNAGSSYFPEVGHNGNGNIENSSNTDAGYIACNNGAIEYDSPPDTALEFEKPLGTGTNLWPTKPTNYTWTTACTQRDPLLLWWTTPANLNSFGHISHTFTHEEQNNATYSDIYKEISFNQAWLKQNGLDQATHYTANGIIPPAITGLHNGDALRAWWDNGIKNCVGDNTRPALLNTKNAMWPYFTVVSTDGFAGMQVNPRWATRIYYNCDTPTCTLNEWIATSAGSGTFDDLLATEKADTMRHLFGLYHDGYMFHQANLRNADVAAITINGVSAKYSIFQAWVETQVQEFVRLVTWPLVTLKHADMSAQFLARYNRDACGYSLSYTTNSGKITAVTVSANGNTCSETIPVTFPSLPSNTQGFTVEKVGSDPATVWVKLSGSPVTFTLSTPITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGG3</accession>
    <name>A0A1Q5UGG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGG3"/>
    <dbReference type="OrthoDB" id="4361859at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="34424" checksum="D8B623DDBFF73D57" modified="2017-04-12" version="1">MATPEITPMNSPSSSPSTFASMSPTIIPSLLRTEACSPKPFVTANSPKSPIGPSKTEEEPATSNSDPELIPFEVQFEHCLKLGYPDQDYYSNRYKNRLPSGYWLANDISLDHVVENIPIVGYVNEYDQPIPSLEGPDIHLTLATIDLITRIGEENDQIAMLDLGQVFHLHGPRKGQLHDAYAWIALRGNEGDRFVMSRRARNHLVPNWKTLIKDWEEFDETITDPCHEVRKIAERASYQAVHSIRALCGERGINLDHIIEEIVKNNNKDHPAAELIPSFHKTLVAVFAFEDAIEEMQTVVDKIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH17</accession>
    <name>A0A1Q5UH17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase TIC 32, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="32782" checksum="47E4E748870496A2" modified="2017-04-12" version="1">MAALSSAIKGMSSTIYSNLFIELPIQKGDLTGQTVIVTGSNQGLGYEASRHFLLLGVERLIMAVRNLEKGKAARLKLLEDTVRDPSAIEVWELDMDSYASVKKFATRVETLPRLDALLANAGLATTTFNLSEDNEKTITVNVVGTFLLILLLLPKLRESASKFDICPRVSIVNSALHYIAPLAEIDVSNQAGIFSRLNNKKTANMAMRYPLSKLLLLFAVRALAKRLEESKGPMVVVNTPNPSWCKSQLMRENESFGNRVGERMMARSTEEGSRALVNGILSGKESSGQYIDNCQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIC0</accession>
    <name>A0A1Q5UIC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000232">
        <property type="protein sequence ID" value="OKP12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIC0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="60" mass="6744" checksum="EA02D1FEC88E18AE" modified="2017-04-12" version="1" fragment="single">IRLEEEQGQLRRSVAWLNAECDILLQCCNDQALELFGRRKAVAALNDGTVDALKANEKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIT1</accession>
    <name>A0A1Q5UIT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9467" checksum="20CD5378136DD204" modified="2017-04-12" version="1">MSSSVKHVNSHRDDVSFAEKAEAIEQERPDEEQFSENEIRKIIRKVDRRLIPMSGLLVAICLLDRANLSNANIAGCVDEELTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIW7</accession>
    <name>A0A1Q5UIW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dicarboxylic amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF45">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012908692" evidence="6">
        <location>
            <begin position="24"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="460" mass="50467" checksum="CCB85D93EDD1FAF3" modified="2017-04-12" version="1">MISYTLVGFTVFLVLSALGEVAGWLPKPSTVADQALRFCDPALGFTLGWIYWLKYAMITPNQLTAAALVVDLWLDHERINPGVWITVFIIIITALNYIRHSLPSQIEYYVSTVKLLVMSGLMIVSLVLALGGGPDHDAKGFRYWQNPGAFAMSKEHMPEALFATCGAMSSATFAYIGSERSGVLARSPNVPKAMNRAIKHTFYRIMVFHLLGITLLGMTIPYDSLRSAFHPGSTAKKKAISPFVAALMEAGIAVLPHLLNVCILFFILSIATYDLFLATKALSDLALRNRAPKFLSKVNSNGVPVYALAASTCMATLAYLNVSQDSKMVFGYLLNLVTMLGLLTWISILVTHICFVRARKAQGISDDMLAFKARFGLPGTWLALVLCVFISWTMVFSSLYVQGSKIAVDPAKFMAAFVGVPAYISLYFGHKIIQKSKHIDPRDADFWSDKTPDSGSVITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJU1</accession>
    <name>A0A1Q5UJU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="814" mass="91966" checksum="83C5E6611F4EEC05" modified="2017-04-12" version="1">MDDYQDSLPQDEATDSGRVIQRRRRPPLSCTECRRRKLKCDRSLPCGQCVRSKTADSCVFVGAQPGEASGSAQRMSPPISRMRLPSGQDEQSGTTGGMFVFDSRMGPKTTSNRVSKRSHPDEIYELRQRLRTLERALAKPGATLQTPETSIYDAFSEVTTSQNSVEGAGVDDRVRFLPECNFRGKKGKTRYFGRSHYSTTVSFFQDIGTFMRRSRKDVKDKEYSDMKKFKCEIWSRESQEHQRAFREQAFELDKMVPSRTVADRLLQLYLDTFETTYRILHVPSFLKQYADYWSDPQSPDMAFVAQLLAVMAAGSRFYSNSPERDERDTYQKPAMKWIMAVQSYISCTFVSPDINFKVIQTQTLLLVARLAVASDGDVAWASSGSLIRSAMTMGLHRNPSCFRKATTPFWSELRRRLWTTIVEIDLKMSLDRGVPPSVDLDECDCDAPSNWDDSELYEKMENNPAPLSTARCTRNFYQCLLSKTLELRYRIVKKINTLRFDLTYDETLRMSEDLCRSMKSASDLFEDNASGMNPSDAARNRFAQSLHLFIMRKFLLALHRPFCLSVVRLPKCSYSRKVCLEKSLEILSQMELPNPTDPILYPHITQLGSGMFCDETFHAAITVCVELSLQAQEMSQASGPAMEGMNTSVLLSMVQSQQNVMLQAVERSLDDFGRRVGSGTGKGSKPYFFLSLILASVKSRIKGEDPLCMIAAASKRAVRVGRGIVGGLPFNEALASADRPPPQRTTGPPCINMLICDYGPLPVLRQLRIRCASSVSTDVLHIVDREASNLPHKPRFLGQRGSRFTSPHPRTFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK77</accession>
    <name>A0A1Q5UK77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine triphosphate pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK77"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="6706" checksum="A6E58E0F13B5517B" modified="2017-04-12" version="1">MKTCTFVTGNPNKVIEVNAILGDSIPIRALALDIPEIQGSLEDIARDKCRRAAKIVTSLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL26</accession>
    <name>A0A1Q5UL26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL26"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11338" checksum="CDF5EB850C56933F" modified="2017-04-12" version="1">MDIRQHANVLLSQGPVLLSIWRPQLRDTPDGPELRAVEVVAHEVGSILVTPCVMSCRSYLVFCDDEGSAVDHPGLRLRLGDFTYKELAQKEMGDLGYNSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL30</accession>
    <name>A0A1Q5UL30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL30"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22501" checksum="BFED417FF9C3B19A" modified="2017-04-12" version="1">MIEGGQPREVTENEDKAQAFLDSFFPEMNTPAADVPTAAPLELPRQPITELGIHRSLKAAKGTTAPGEGNLPMVVCKQLWTHLGSVTARILNTSMNLGYHPKQRRNAKIVVLRKPGKADYSIPGAYRPISLLKTLGKLLDASGPAQIFLRTSSFALQTAIVLCIVRTLRVACDWHSIERNGFKEGPARLKQHGFWAAYYEVTDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULN8</accession>
    <name>A0A1Q5ULN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULN8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULN8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="28324" checksum="38F0275F448787DA" modified="2017-04-12" version="1">MSPTIQLEHALHVLSVLPSAYAWTFVWRNASDNAFVEHDQQPMSCKQINNAQGELFEWDSEDGPFAISLYANTDCSGSPGGYATHIFNKNASKPILSFKVDSTATTTTSASSTSTTSISSPTTSSTAQTPTAPAATASPSSSPSSSGDALSGGAIAGIVIGAVAGVAITGGLLFFMGRAKRQKVNPDTGPSMAYTDPSFRSPSSYTSPSSLGPGLAALEAQKPPQARAAPGSGTGPVRVVELQGDTTAAELSNAHVVNELESPVMTKSPLKRGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULW9</accession>
    <name>A0A1Q5ULW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="77" mass="8808" checksum="790AFDF78847F546" modified="2017-04-12" version="1">MFATRSTPSASGAYLQILELLLASSSYLICRANYTRQIWEIYQQLEPAEREFWDLLNEADSSDGSTLSTFEGYSDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMG4</accession>
    <name>A0A1Q5UMG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMG4"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF27">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="300" mass="32236" checksum="0B6C545714397A47" modified="2017-04-12" version="1">MVAAKMETLCLLGCGNLGSAILNSLLETSDSDPLFSRFIACVRSEASAQRLTEKYPQHQNRLSISRGDNVRAVHESDVIILGVDPADIESVLKQTGLPEVLEGKLLISIAAGWTRQKLEETIYGSETTNANKSGRAWVVRTLPNIAAQVSQSLTAIEVSEPSPPESYLKITTAIFERIGRAVEIEPRLMNATTAVGGSTPAFFAVICDALIDAAVAVGMPRNLAHTMIFQSMQGTATMLQSGMHPAILRDQGTSPEGCTIGGLMVMEEAGVRGHIGRALREAVTLARLMETTEHVNDTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UML2</accession>
    <name>A0A1Q5UML2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UML2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UML2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="53233" checksum="AB35F8E7BC4148C8" modified="2017-04-12" version="1">MDETTRGFLAQAIRDALTSSGIDYNEGYIDSLISKVDNDSAHLLDLPVDSSSSYQADSAYTLKAMSSILFECARVNFAIALYGHRTSRIPTTTKPENIRKYVDEISEFDYETAVDVIRRDNALATGKGLQNRYNETIFWKIILKGAALIDHSKLPAAKGPADGFTMAEKAATKKFMEDAGYGLGAENQRQCRIFWKNLFQMREAGIDKVLYYRTKEFDSYCKGYPKTSRIPLVDVVMKWETQHRPHIEQLETRALRLAKGDPMRLSDLENPQVVERLKVHESTWNNAKNEWAFTSEEESFKEKGLQAFSPEVICAPYDNQLASECGIDKSAFTFLLPKDGSSLFVCSIVPVREGDFLGIFAGKIRLSENRKTTHGIRGPIDNLWLDYSQVTGTLNQMLVSEPGGSANVRLQWDVIQDDIGTDSCTSWRVSVKATKPIMPFDPLVRAAAQREQYVLHSSSENAKRGFLEFCEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNE6</accession>
    <name>A0A1Q5UNE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNE6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNE6"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24196" checksum="784A68A70D16285F" modified="2017-04-12" version="1">MPSIALHPRSSALVTDPSLSVHNPLPQLLQTPSGLALLELQGTINVPTSEAEQGDPSVDNGIAESTSYETPIGKLMFPDYSIHNPDDTKWMKRVYLYVGRYQRMTGEVKKLPRPIAVLQKRAGTETEELEVVEIVRYKVFFKSRPEPGNQDLRELFPPGAGAGLWDASSRDYNMVMAMLHQLALVDATTDKYNAARVMKHKIYHSAPSLRVLPLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNL2</accession>
    <name>A0A1Q5UNL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacilysin biosynthesis oxidoreductase BacC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNL2"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="27938" checksum="6A1D8CB06A258F1D" modified="2017-04-12" version="1">MACQVKGTAFITGSGSGIGKATAISFAQNGIESMALVDLNLPLLERTRDELRALFPKIKVEAFQANVADETSVENAVRETVEHFGGIDIGINCAGISGAPTPTDRMTLAEWQKVIDVNQTGVWLCQRALIRQMLQQESRGGREGRGVILNVSSMFGVSGPPGPFDIPHYTAAKHAVVGLTKMDAKAYSRQGIRINAICPGFVDTPIIKQQIESGSMNAVFEMTPVGRPAQVEEISDAILFLSSPMSSYMCGAAMVVDGGFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP29</accession>
    <name>A0A1Q5UP29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_68</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP29"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="74"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="821" mass="91023" checksum="2A46D7CE141BF8DC" modified="2017-04-12" version="1">MSYSPTAVRFFTAPKPLGNAMDSVTTKITAAESQGNTVVRPNVSPEQPSSEAVKVHTPKEKGLTFANQDSLPKLPIPDLEDTCRRHLEALSPLQTIREHEETKAAVKDFLKTDGPILQEKLRTYASSKTSYIEQFWYDSYLNFDNPVVLNLNPFFLLEDDPTPARNHQVTRAASLVVSALSFVRAVRREELPPDTVRGTPLCMYQYSRMFGTARLPTDNGCVISQDPSARHMVVMCRGQFYWFDVLDDNSDLIMTEKDISLNLHVIIEDAAQTPIQEAAKGALGVLSTENRKVWSGLRDIMTKDAASNNAECLNIVDTALFVLCLDDTEPSSTAELCANMLCGTSEVIKGVQVGTCTNRWYDKLQIIVCKNGSAGINFEHTGVDGHTVLRFASDVYTDTILRFAKTINGQAPSLWATTSPDPAKRDPRSFGNVSTTPRRLEWDMTPELNIALRFAESHLSDLLYQHEFQVLDFEGFGKNFITSMGFSPDAFVQMAFQAAYYGLYGRVENTYEPAMTKMFLHGRTEAVRTVTPEAVEFVKTFWGENPAEHKIDALRTATQKHTAMTKDCSKGQGQDRHLYALYCLWQRSFDEGLFQDSSSAGGYSSPSDGMLSETSEDNFSSSPGSGSIRGLRTPTPPTPAIFSDPGWDKINTTVLSTSNCGNPCLRHFGFGPTSADGFGIGYIIKDDSISFCASSKHRQTARLMHTLESYLFEIRKLLRATNRKATSPRTSRARETEMLAEGLQADTNRRGRVVRGDNRGADTPTTTTDSGEIEDDGMGGYGFFDAGMLLHALKGVSAERERGDKPAKRKFVGKKLHLNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP78</accession>
    <name>A0A1Q5UP78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_34</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP78"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP78"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="123" mass="13806" checksum="B2C888F2678125B7" modified="2017-04-12" version="1">MTVSYQNTLFPDDEILRLLFKAARSSKRDIIVDFLSGITADYTQLLADVIKTRQRVWTNAKRSTFDDRGLILPESPYVFLLATSSYLVPVASFAILSIGAAICPMCKLLQLDPTQFTTENILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPD5</accession>
    <name>A0A1Q5UPD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_14105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPD5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="55641" checksum="2FD29269E7F26AC8" modified="2017-04-12" version="1">MSRSFTGCTRCKARRQKCDEQRPICGRCQSAGVQCKYAMQLQWGGRAFSRSRFGACVDTGNMQRLEYSPGEFIYTTKSAQAQAQAQAQAQAQAQAASELTLIKPVDPFSSLSPDQKALLHHFINDASQITASHSGMQQDICRMIVPMALQTPSLLYATTALSAIHIQALQNQSESVKSAPDIARLMALSLEHFRKELQNPSSKDSEALVATARTLCLAEIHSGAINPNSWRAHIEGARALMKTLGTTGENSLRTESGFRRYLDRWYWSIVSLTALTGNGPPIGDTSDFAPSDLAGQRESPDYLDDYWGFTVDLAAVFRQIGAAAWRTHQAEKEFQSQGFVAGEIDGNAEDEAAALESSIRELMDRGATSLPSFYPGVAEGLSAESVQHLALCNEAFQHSALIQIHKRLRKTPTTSVLVQQSVHRILECTAQIGPSAGLSPWVMLTTPLFIAGCEARGEDRDTVRQLLASLHDTIRVPNVLQSLKFLEQYWANQLGEDEDWSHFLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPP4</accession>
    <name>A0A1Q5UPP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_14048</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPP4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPP4"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="19">
        <location>
            <begin position="311"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="226"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP14436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="571" mass="61962" checksum="2C61D8399AFE1779" modified="2017-04-12" version="1">MGKGTDKLYITHSEWASEDAFSASAGAGVARARQSGSHATFKRLPFNFCSLSLQPFSHPVCTHTGTIFDLTNILPWIKKHGTNPVDGSPLKSSDLIKLTIAKNEDGEYVDPVTYKVLTDNTHIVALRNTGNVFSWDTVERLNIKGKMWRDLVTDEEFTRKDIITLQDPQNIESRNLSSFNYLKEGETDIPGQTQPTGSVNANALGSSAKILKAKEAVAKARAERAQQAGSAASKAVSKTGAAGTGLSKSGTAQQGKPTPYNAARFTTGKAAASFTSTGLTPHTSAELAVLSEEEYMLKRGRVKAKGYARIDTTAGHLNVELYAEYAPKAVWNFIQLAKKGYYKDVTFHRNIKGFMIQGGDPTGTGRGGESIWGKYFADEFEGPLKHDGRGTLSMANKGKNTNSSQFFFAYRALPHLDRKHTVFGRLIDDPSPSSTTLNTLETHPVEANTNRPTPEVRIKDVTIFVDPFEDFLKQKRAEGAKDTGAADADGDEAVQCVDDDRVTWTGKRVRGAGTDSNAEGAGGVGKYLKAALADRGDEEDEIVEFVDDEPEPEPVRKKAKGTGGFGDFSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR35</accession>
    <name>A0A1Q5UR35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Myb-like DNA-binding protein myb-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR35"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902806">
        <property type="term" value="P:regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000037">
        <property type="term" value="P:regulation of stomatal complex patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000355">
        <property type="entry name" value="Transcription factor MYB124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="35961" checksum="0A61859B89471446" modified="2017-04-12" version="1">MAPSHRRGPWVPEEDQLLLQLVREQGPNNWVRISQHMHYRSPKQCRERFHQNLKPSLNREPISADEGLLIERMVNEMGKRWAEIARRLGNRSDNAVKNWWNGSMNRKRRGLSTPPASRTFNGRIEAPFARASIVSPTRPRFATRPWAESSPIDSSEVFSHSRRESTVSTTRQLSPIYTLPSINRPIETPLTSPAFSEATSIEPPSMVSDHNSVCSSSPRTLPSPQLLPMPVDLRAQYDVRRQSVVSVHVVDDSPPSYSTRSLESLSEVASKRRWMEHQPALASWHQPTDSFSKPWETRPVEPPRDTRMGVNNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNX6</accession>
    <name>A0A1Q5SNX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNX6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNX6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11459" checksum="2C8320E81E8AAC74" modified="2017-04-12" version="1">MSTVSKESVATVRIYGKTSEGIVEDFRSFYFDLALSSSEAVLKLVLDVITHDHILYGSDFPYASTDKSTGFKQILNNFPLDQELRDKIYFQNAHKLFAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPC0</accession>
    <name>A0A1Q5SPC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000767">
        <property type="protein sequence ID" value="OKO89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPC0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="61" mass="7042" checksum="D2B6657B902C2D88" modified="2017-04-12" version="1">MQNEVPLEQLHFSQYLLDQLCRRRVISRVYDSEALESCDPTWNQCDLCADRLASTLAILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWG6</accession>
    <name>A0A1Q5SWG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWG6"/>
    <dbReference type="OrthoDB" id="4917591at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="41597" checksum="B37CDBBF06AEE8FC" modified="2017-04-12" version="1">MPSLLGLPEEVLSQIAEQSLCLGAPDAPINSRRTFRIKERVFHEHAERAAPVIPLLLTCRRLNAIASSLLLSRAVFSVCDTRDLRHLVESMGGSTLSQVRNFSVMLYSDDDYEHDPRDDETAQEDIEEATELLEQLPSKLHRLCLQMPFHSYPPFSYNRGTDIRLRQAMDKFAGLEELRLDFFTHYVHIDMFTNMTANAYATFHEWVEPPAPKFPLLRRLHLEGCLTPLLGPKGLATALSESQLPCLEALIFEGILHDSDDEDSLVFEPEALTTMHPLHEFCWVPYDFDEGIRKTLGNPHSPPTRRHLDELKARHGATLRVLRIDFGERESCMGPWELDIDQGYLDEFKEAMPNLSEVSLEMGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZB3</accession>
    <name>A0A1Q5SZB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZB3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZB3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="39398" checksum="5F87278E6C51619D" modified="2017-04-12" version="1">MSGELIIKDQPVDGTDAFALPPAALSPAKGDSASRRSSRSDPTYVPASPTSPELAARGRSTQHARSGTATKRPLEDLDLPPPPTRTRKIIQMKPKSPATAKSPAKPKDSAKGAAQTAAEPANATASASKKKQPSATSAAGRKIARKTAHSLIERRRRSKMNEEFGTLKDMIPACRGQEMHKLAILQASIDYVNYLEKCIQDLKTNGSAHPTAAPPSPTSPEFIAETGTDTVMHQAPRRPPSSTYYSSASSVNSPEILPPNTHFYDASPSFSPRTRMPSVHTLPEAPSILPSPALGPTYASMDKLQDLQGIDHEASAALLMLTRDRRGTADSISEHFQGSTALSTSEDSRMSVDSQRRKGMSVRDLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZC4</accession>
    <name>A0A1Q5SZC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZC4"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="300" mass="34739" checksum="A9EDA2BDC1237653" modified="2017-04-12" version="1">MPFTKLVKNDAYFSRYQTKYRRRREGKTDYYARKRLITQAKNKYNAPKYRMVVRFTNRDIVTQIVYSEISGDKVFASAYAHELKRYGITQGLTNWSAAYATGLLLARRTLAKLGLADQFTGVEEATGEYTLTEAVETDDGERRPFKAFLDVGLVRTSTGNRVFAAMKGASDGGIFIPHSERRFPGYDIESEELDADTLRNYIFGGHVTEYMETLADEDEERYKSQFAKYIEEEIDAGDLEELYQEAHKAIREDPFKKDEDEGEKKTKEEWKAESKKYKVAKLTHAQRKERVQEKIRQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZE2</accession>
    <name>A0A1Q5SZE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PBSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZE2"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35425" checksum="8FB585E2D4AF5F8E" modified="2017-04-12" version="1">MTTTSAPPAAASAIPKASLPNEENPKDQDQNQKSPAKEVQISKPKYRLHAEDLRHPESASFSIYIPDVTATLDTALGHIVRYLYTSPEYGSTEELKSAPKLKRPHFVPSIPQTRSVTLFLRDFGGVAYTTGTELDDDHKEIHLSLPYITHCKNSAAKADPVHELAGVLTHELVHCYQHTSPPDSGKDGKDIPGPPGGLVEGIADFVRLKAGLSPPHWTRPTSSSQREKKWDAGYQHTAYFLAWIEDVWAGEGAVGMLNDRLLRVGYVGEEEDDEDCHEGGFWKSLFGAGVAELWDEYGQWLDDGEKKTKGNWEEEIINPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T099</accession>
    <name>A0A1Q5T099_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_11976</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T099"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T099"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO93697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="33747" checksum="3746C354AF269CAE" modified="2017-04-12" version="1">MSSQADKSFMGMPGFVVDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMLKQGRLDRKYNGIVDCFKRTSAQEGVVSLWRGNTANVIRYFPTQALNFAFRDTYKSMFAYKKERDGYAKWMMGNLASGGAAGATSLLFVYSLDYARTRLANDAKSAKGGGDRQFNGLVDVYRKTLASDGIAGLYRGFGPSVLGIVVYRGLYFGMYDSIKPVLLVGPLEGSFLASFLLGWTVTTAAGVASYPLDTVRRRMMMTSGEAVKYKSSMDAARQIVAQEGVKSLFKGAGANILRGVAGAGVLSIYDQVQLILFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1A1</accession>
    <name>A0A1Q5T1A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1A1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1A1"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF0">
        <property type="entry name" value="RE45833P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012027497" description="FUN14 domain-containing protein 1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18183" checksum="3A870042F999A747" modified="2017-04-12" version="1">MAFHLFSPPSTLLRLGLGLGIGLSAATLHPLSPFRAAPMRCEYSAPYSRTGGQASAETGWAVNPNDPSLQKQAKNAFLTPENMRQISLGSVLGLVAGVGLRAFSKVLVVVLGMGVVLVEWAASKGYNILPLNRLQKYVKNADLRRMVSENRPFKISFGAMMAMAAFAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2R8</accession>
    <name>A0A1Q5T2R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2R8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2R8"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012208733" description="Secreted glycosidase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="286"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="88381" checksum="29A26AE0F07BDCC8" modified="2017-04-12" version="1">MPALKTNIITLFTITLLLLLHFTTATKDDLHYVNPLIGSTAGGNVFAGASLPYGLAKPVADVDGQNTGGFSTDGSNVTGFSHMHDSGTGGNPSMGQFPLFPQYCPDNVVDNCKFGKSARATHYVNESVTARPGYFALELVNGIKAEMTAARRTAVYRFTFPETRADDGSVLDPLILIDLTDLWDSRQNASISVDPDTGRVMGNGTFLPSFGAGSYRAYFCADFAGAQVRDGGIWVNDRAGSEVKEVFITRGFNNFYLQAGGYVSFVRPGDGVVTVRVGVSYVSSEQACSNAEDEVSDPVKDFESLEEAAKIAWSEKLSPIKVISGGVSDGLLRSFWSGIYRTMLSPQDMTGENPLWKSDEPYFDSFYCLWDEFRAQLPLLTIIDPQTQSKMVRSLLDTFKHEGWLPDCRMSLCKGWTQGGSNADVVLTDAYVKNLTGIDWELAYKAMVNDAENEPLEWSYEGRGGLQSWKKLNYIPYLDFDYLGFGTNSRSISRTVEYAYNDYGLAVVGKGLGKKEYTKYLSRAGNWKNLFKADQKSFLENGTDTGFTGFFQPKYLNGTWGFQDPIACSALASWCSLTSNPSETFESSIWEYLFFVPHDMASLIKLLGGPDSFVKRLDYFHTSGLADISNEPVFLTVYDYHYAGRPALSTSRVHSYIPRTFNASNNGLPGNDDSGAMGSFLAWSMMGLFPNPGQNVYLITAPFFEAVEITHPETNHTATIRNVNFDPTYRSVYIQSATLDGKPYTKNWIGHEFFTRGMTLELMLGDRESDWGTREEDLPPSLSDALVQDEMQMQMLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Y3</accession>
    <name>A0A1Q5T2Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Y3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Y3"/>
    <dbReference type="OrthoDB" id="5402816at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012589">
        <property type="entry name" value="Pmp1/Pmp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08114">
        <property type="entry name" value="PMP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7471" checksum="1CCED9327169E4CD" modified="2017-04-12" version="1">MPAITVTNQPQGTDMTTITKRGNWASREPGVILVFAIVFLVGLGIVSLFVYRKWMARKAKKQSFQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T402</accession>
    <name>A0A1Q5T402_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T402"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7115" checksum="A08871D8C246E0C0" modified="2017-04-12" version="1">MIRKKTSRIGVSSLKEEYDVIKVVEDGETRVLPTTTTVVYDPALGRLFLGALSSPFTVICEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5L8</accession>
    <name>A0A1Q5T5L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5L8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5L8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="216" mass="23375" checksum="802B06796C6548FE" modified="2017-04-12" version="1">MASSNIGSIADTLAKGDVPVPWCKEFEKMINGKNFTTSNSEKLMEYKLSTLHKLNEFNDTSIPDDSTLALLKNRRMVVAKRMFGRLGKNASIEQAFFVTWGCNTFIGDDVYINRDVSIYDNSLVQIGDRVLIGPGVCICTGTHAIDAKSRQENEGTSFALPIIIESDCWIGARATILPGVRIGKGTTIAAGAIVTRDIESGCVAGGVPASVIRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Q3</accession>
    <name>A0A1Q5T5Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neutrophil cytosol factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Q3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Q3"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="63063" checksum="17FA3C44CDC1F45F" modified="2017-04-12" version="1">MSLKQEIETWVQALDAYDNQEFEEALRHFDQIADTSKILFNCGVIYATLGEHDKAVECYQRAVGLDRYLAIAYFQQGVSNFLLGDFEEALANFNDTLLYLRGNTSIDYEQLGLKFRLYSCEVLFNRGLCYVYLQQMVPGMQDLSYAAKEKVTSDHDVIDDAIRENADGYTVFSIPVGVLYRPNAAKVKNLKSKDYLGKARLVAASDRSQGADHQWRPMIIDKGALEDREGVSWAATNLVHKGISSRTRQQSEPPLNRNVFPPTPPPDDRSTSNGSVAGSSHHRSSSLRMGRPPRLDLERTGASLDRRAPGQESAPTAEKPRIGTTRTASEPRGPASRHQNMRGFGEPSRGAWSQGHRRNLSDTSSNPTPNPYFNFPEQPEYAHPDSHTYASPANLSSAGWGRGRHQPPAFIDEEDEYGSDACDGEPIKDGSFELLGTAPGGPGSSPAQSMQQRRTRSPARYSRRANSRRPEVRRFRTKVHAPDDIRYIMIGPTVEFAEFEGKIREKFGFQGGLKMRVQDDGDMITMVDQEDLDLLLASAREVARREGSEMGKMEVWVEERLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Z2</accession>
    <name>A0A1Q5T5Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_11168</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Z2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Z2"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="16">
        <location>
            <begin position="437"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="526"/>
            <end position="527"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="664"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO95656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="768" mass="85474" checksum="790134D9D2993669" modified="2017-04-12" version="1">MVQSAVLGFPRMGRVRDLKKATEAYWGGKSSRDDLLAEGKRLRAEHWGLIKKAGVDSIPSNDFAFYDQVLDHIQLFGVVPERYSKYKLHPLDEYFAMGRGLQKEGVDVPALEMVKWFDSNYHYVKPTLQDNQVFTLAAEPKPVVEFLEAKAQGVTTRPVILGPVSFLTLGKADRGQSVDPIDKLNDLLPLYVELLAKLKAAGAEDVQIDEPVLVYDLAPKSKAAFKPAYEVLGNLGDKAPRLTLTTYFGDIVHNIEVLSSLQNLHAIHVDLVRNPEQLDAVVAALGPKQTLSAGVVDGRNIWKTNFKTAIEKVEAAIQKLGKDRVVVATSSSLLHTPHTLESEKKLDPEIRDWFSFAVEKLTEVAVIAKAVTEGPASVSAELEANAKSMHSRATSARTNDPAVKARQAAVTAEMHNRKSPFATRIAEQTKTIKLPLFPTTTIGSFPQTQNIRVTRNKFTKGEITAEEYEKFIEQEIRDVVKLQEDLDLDVLVHGEPERNDMVQYFGERLNGYAFTTMAWVQSYGSRCVRPPIVVGDISRPAPMTVKESKFAVSITSKPMKGMLTGPITCLRWSFPRDDVHQSVQAQQLALALRDEVADLEAAGVAVIQVDEPALREGLPLRKGAERDAYVKWAVDAFKLSTAVARDETQIHSHFCYSEFQDFFHAIAALDTDVLSIENSKSDAKLLKVFVDEKFGAQIGPGVFDIHSPRVPTEQEMKDRIEEMLQFLSPEQLWINPDCGLKTRKEAEAYAQLKSMVAAAKFYRAKFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6K3</accession>
    <name>A0A1Q5T6K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional coactivator hfi1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10897</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6K3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6K3"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="422" mass="46752" checksum="370649013E765289" modified="2017-04-12" version="1">MQIDPAALSRNDSSNQAKSVANNPSTTVKSSRTLPSVPRLDLEQTYTELKAAIGDKWAEYKESTAFFLLGHYNQNEYASRVDHFLCADTKIEHLHNNFICAIIANLTRDLPDHGVATWVSANDKPSMVSKPISGDAAEQRLKTEVMQLPPRDRRRIKAIQERDPNDAVPNELEVYHQAKQIKLPSQVPASAGGLNKTNWELEIRKRYAQPLAGDTGEFPDAESIYARMVPMCYEESLPGGAALPCAEFMAIATETFVKDVLSSMFSRTRSNGPSGTINGMMMRKYRQQLEREELAYTRGEIVKDTATGLLPVEAKEAATRRSLGVRDLRLTLELGRGVLGHMPLLIDQVMGGYFEDELGTEKQDRLENGVIGAPETKVEANDDDEMDLDDDDDIALSDWEGGTALDREQLSGLLDDCLSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8A3</accession>
    <name>A0A1Q5T8A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II-associated protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8A3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8A3"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="53753" checksum="7EC3757AC52E6414" modified="2017-04-12" version="1">MSSKSREDKSSSGFHQEYIASLRYRNDLPPPHMPPKLLDIPHEGLTRFLTPGFASNLARREEPNIDVDAEGGMPIDLVGLPGLHLGDESAIMAPEHPQPMDPADLPLLMTLDQLRNPAPRNTNVSFLRRTQHISVDRTAGPGSAPTKGLNRAVKKGKISVEDPKHIKKFIQKGFDIAYPQSKHIGEDTESQVRGLPATKAETDAWARPVHPDNPKLKPVGFFPLMPDLSGFPDPGGFVQFKFDKAPVSAIAGKRDKRMDVALLHPSAPEERICQEHASKQALHKANPDLYPDPGPIPFDYDLHLPEEQDSVKKVYASMDLSNPDRDNEDLYTNEGPDGAKYHRFDRERTFATSAQTLNTDQKLKDIALTLHKPREGETKQQAAYYYPIISKVRLKPERARTIAQAGLAPTASQAPEEKIDQFHVTVRDPDEAEVYKRSLHRANIDPKFAQTLPPPPVEEDVLEEEEEEEEEAGDDTRMSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8F3</accession>
    <name>A0A1Q5T8F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8F3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8F3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="20127" checksum="2E536E5E9429F32A" modified="2017-04-12" version="1">MDDPWHLLEALGLIVIPRTGSVQTVRRFFEFGFDSAHHLTFTFIILLRCTIEASDATVTESCKTSLVQFWAKLQDAAENESWDLAVMCISRCGESMSKVMSYLNAQGNKQAASNDGVTQGAGSVSEGVDRQGASDSAISGLGELIPDALPFSNLDLLFENSADTFWSGLDFAPLYDEVDTGQVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8S4</accession>
    <name>A0A1Q5T8S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8S4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="704" mass="78913" checksum="82688894127B0786" modified="2017-04-12" version="1">MAPPAKRSKVGSACQRCRRQKLKCDIKRPCTLCVRAGVGCETADQWRVIQKPQKDQRRKTSSKHKRNSEDEQPENAGITKRPWSSSTMSLVEGAFSLHSSTPPETPSVNALPGGQGLHHSVSPRLGITRPADRRPGRPPTTNSWPQGPRPALAELVSLLPSQEVAALLVDTYFDRIHWFMLIFHQDDFRKTWQEMYDLPRQQLIESFPNQGFISTFLVVIAIALQYAGEHRQDLLKAHGISPMDLKERILSTTRAKILDIVSLGSLEAVQTCVLLGTYYLYHGKPELAWPVCGCGLRIAQALNLHRKLPQTAFITSEAYRKNETRKRCWWAIYEIETFCSMSYGYPHSIKDSDCDVEFLDPSAKSVTGQSPASADVMHDCTATLLSYKYLMSKLSVLINDILTDLYGLGSLKAETRQGGSTGSSSLQRLVRKVSALDARLQKWSAEIPAELRLDRADTTTYTSIDEMDQDIGASGPRFEAHIYQLQDLALKLAYENARILVHRPLLAYKSKFPAETETEELSSLVRDTVNLSLQSCRDAALSTSNIEKTPIFSLAADTYATAFIGMHTFTAGVMLCVLISMEPLALESHESKMGLRRLLRMQSLLKSRAHSSLNTQGLEILERLTKLVMEKELKEMLKSSEDEQRSVPQPGYSRDESNAQHLNESGQMLAMTERILDNEATFNYVEDPAMSQALFDFDQGVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8U3</accession>
    <name>A0A1Q5T8U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8U3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8U3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="492" mass="54147" checksum="C07BA3674D872856" modified="2017-04-12" version="1">MPSDHFPAPNGMLPYWRTEPHRLDNYRSTEALPKESDIIIVGAGYAGSSVAYHILDQIKPGSKPPSITILEARQACSGATARNGGHMKPDIYNFVATLEAEYGVEAAAEVAVFEARHVHAVKDFVDKERIDCDYTVTKAIDVQLCSGHFQKLKSGYERLVSNGFEPTKPARFVNAEDAESFSGVKGAVGCVTYDASSIWAYKFVLHLLEKVVSQGVNLQTHTPVSKITKSTNESASSSHWQVETPRGTITAQKVILATNAYTSALAPQYQNKIIPVRGTCCRIAVPPASTVPRLTCTYTLRWNGWDYDYLIPRADRSIVVGGARTAFIHDLNNWYNVSDDSRVLEGAVRYFDGYMQRTFVGWEDSNAYTDRVWTGSKCMMITPCICEHTFVFNRTGMVRLTWAVMGYSSDGLPHIGAVPGQQDEYILAGFTGHGMPQIFLAAEGIAKMVVGDVAFEETGLPRLFKTSQSRLDKQENKILSSAPEGGSSLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAV6</accession>
    <name>A0A1Q5TAV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Benzoate 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAV6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAV6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="36146" checksum="847A97E14863B6D5" modified="2017-04-12" version="1">MSVFVSFGERISPYAFLAVIFVLVEPVLFNTRDTRVHQRKKKYLSPAFSAKNLNDYEPHMSAQVTKLMTCITRHAQGNGEARIDFNEYCDYAFGKPFGFLDKEENHLNLITTIDARGEVLNAIGHLPGLLRPVMKYFYLDPFWPKGLQATSNLASIGKNAYYQRRDQQDSRKDLLSFLFNAKDPDTGSPLSETEIIAESISFIVGGSDTTSSTMTNVVDIVSRLPEIQKQLADELDKAFPGRMSAGWIAEFQPVNQLPVLNAVVRETMRLKPTSSTGLERVTPPGGKVIAGIFIPEGTLVSVPTLNIHHDETAFTVCEPGQSGSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBI4</accession>
    <name>A0A1Q5TBI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Archaemetzincin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="ARCHAEMETZINCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910:SF1">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="490" mass="54596" checksum="7A0A99E460904115" modified="2017-04-12" version="1">MGPPPRPKTSTQFRPFLSPTVGPTSTGQHITKWAAKIASSTHANMSSNSTPRCNHSSASVTCSQNAAKAGFKRPDTKQRLAATRSDKPSKIHDFKSIPADDPWTFPAPLLLPGDDLSEDPEYPPQSFQEWLDEEDRNPVSAKRKTVYVVTAPEIEDDVQFMRTWDNRLGDRHHVAQPSAEAILDYLQAFYHGLPVKSLPRLTPAFTAWDEEPKTKRKPRQPRQPKYIALKFGNECVRIRIRPSPDGIFGGQLNLDDLLDAAIAMLPKDAYALLLLVHQDLYEDEDDEFVCGRAYGASRVAVVSSARYNPALDEHQSVERLHAWPASHCENYIATCFTTSGPKVKRQKTSKPTKPIEIKDSSSISSSPLMAAMSIYRDLETTNRSPSALSTLWLGRMCRTAAHELGHCFGIDHCVYYACAMQGTASIREDARQPPFLCPVDLAKLTHATGATAAQRYKALLDFCDRPEYGECLFFAPFAEWIRGMLGTTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC59</accession>
    <name>A0A1Q5TC59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_9740</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC59"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="17">
        <location>
            <begin position="37"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="18">
        <location>
            <begin position="264"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="19">
        <location>
            <begin position="532"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKO97814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="858" mass="94600" checksum="0FD074A2642F016B" modified="2017-04-12" version="1">MATKRKASAMGAGAEDEPADPSDELAFYCLGGGNEVGRSCHIIQYKGKTVMLDAGMHPAKEGFSALPFFDEFDLSTVDILLISHFHVDHSSALPYVLSKTNFKGRVFMTHATKAIYKWLIQDNVRVSNTSSSSDQRTSLYTERDHLSTLPLIETIDFNTTHTINSIRITPFPAGHVLGAAMFLVSIAGLNILFTGDYSREEDRHLIPAEVPRGIKIDVLITESTFGISSNPPRLEREAALMKSVTGILNRGGRVLMPVFALGRAQELLLILEEYWERHPELQKVPIYYIGNMARRCMVVYQTYIGAMNDNIKRLFRQRMAEAEASGDKSVTAGPWDFRFVRSLRSLERFDDVGGCVMIASPGMLQTGTSRELLERWAPSDRNGVVMTGYSVEGTMAKQLLNEPESIPAIMSKVSAVQGRGRVPGGNDEDQKVMIPRRCTIDEISFAAHVDGVENRNFIEEVAAPVVILVHGEKHQMMRLKSKLLSLNAQKTIATKVFTPANCSELRIPFRKDKFAKVVGKLADMAPPSGQDDGQLMAGVLVQNGFDLSLMAPDDLREYAGLTTTTITCKQHLTLSSASMDLIRWALEGTFGAIEEVGSKMKELNGKAVASSSEQEAADEEILMEEKQTYLVMGCVTLHYHPRTREIELEWEGNMMNDGVADAVMAVLLTVESSPASVKQSAKNKHHHHHHHHDDEEDLPALQNPHAYVGPEDRLARLLMMLEAQFGSDIGPIERPRVPADLVNGTDGTTEDIKEERIADIESAELDRLHALGIPVPGLEIKVDKHVARVWLENLEVECANAVLRDRVRVVVERAVETVAGLWAPSSMPKEVVVSNGSAKAHMEIDAAAKKAAAIEAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC80</accession>
    <name>A0A1Q5TC80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phthalate dioxygenase reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_9758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC80"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054582">
        <property type="entry name" value="DmmA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22290">
        <property type="entry name" value="DmmA-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="10">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="244"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="9">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO97832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="551" mass="61458" checksum="24C530EBD5596B71" modified="2017-04-12" version="1">MNCIISELEEPWERDELVEVRTGKAKPVFGLPVQSAIFKSVRYGAVPVDALGCWGDEHVYEFHGGTDKALLQYCSRHYGVWSEELPDSAHLFRVGGFGENLVARRANERNTCIGDIIRIGPDVIAQVSLPRQPCYKLNHRFQEKNLSRFSQEKSRTGWYYRIIKGGSIQAGDELVRLERPNPDWTVARVQHYLYMEKDNFDMMKELAVLDALGSEIRNIFKNRLNKKFENQEQRLVGDSAMAVDMWSEYRLVKKAQETPTVTSFVFMAVQPKQSPEPVPPGTHVRLKLGGRLIRAYSVVHGNRKQLTLGVALDRESTRGGSLYLHENLQEGDIITISNFAATFPLAEKADRHILIAGGIGITGLLASARKLQAMNQDFHLHYVVRSLDELAFEPLIKPLGSNVSIHCKEEGTPFDVSNVLQKVDSNSHIYCCSGERLIKAVSDTAAELGLPKENIHFESFQANSTGDPFTAELVESKKKLEVAAQDSLLDTLRSAGFDIPSTCEAGNCGTCRVGVRSGRVEHRGTGLLENEKDTAMLSCVSRGIGRIQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC81</accession>
    <name>A0A1Q5TC81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC81"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053299">
        <property type="entry name" value="ASTRA_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44156">
        <property type="entry name" value="SUPERNUMERARY LIMBS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="344"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="457" mass="49657" checksum="2EAB77ABB9FB75AE" modified="2017-04-12" version="1">MDPYGKLPIVHGAAFDSLEDQHDDECLLGTITEILNDIREWAASPLGKCILWLKGMAGTGKSTISRTVARSLKDNNYLSASFFFKRGEGDRDSRLLASSSCDNTIRVWVSKTGILLQEFTSYSGQARPIAFSDDSQLLALGSRDNTVRLWSPVTGVLMQDLKGHSGRVTSVAFLPGGQLLVSASEDKTVRIWNPVTGTLDQPLEGHSGVVEQMWKLEGHLGWIEFIAFSPDGAHLVSVSGDGTVQLWNPATGARERRLLQALEAHSGSVVCVAFSPNGRLLASTSGDNVVWVWDLVQGDQRQLDSHSGSVSSLAFSPNSQRLVSGSGGGLLLWDLTKGHLQNTLRGHRGQVEAVAFSPNGRLLASASEDNIVRIWDSVKGIMQKRDTGHPNEVQYLAFSPGGRLLASASVDGTVGVWDPITGTLQRMYNVERFIIHIEFARKGLPIFTTSKTTCFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC82</accession>
    <name>A0A1Q5TC82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC82"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="193" mass="21792" checksum="1106B2C008BD4915" modified="2017-04-12" version="1">MKNRWDKDPKLYEAFGESDSSFGRLSYRAAKERKNVLQSLFSKKAAVQTHELIEAKNAVVKESLRMGGGATSPLLRVVPETGAIIDGVLIAPGVSPSPCLFREYTDTLTILQRQTVVGSSSHFVHRNGDIFHDPDEYIPERWMDGRGDELEQHLVAFGRGPRRCIGENFAWVILLTCIAHFYRKFNVELDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCH8</accession>
    <name>A0A1Q5TCH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_9859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCH8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO97933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="31194" checksum="C7D39514C8FACCDC" modified="2017-04-12" version="1">MADATTSSSQATPGDPNISWPIERLAHTTDSEWHPSFSNQRRGSNASSSSSSSSQPDLDRSNYPDGTKSLSGISLRAFLLGTTLGATSILTILLTTISPTPFWRVPFFVAALSLFHFLEYYVTARYNTRYASVGAFLLTSNGWAYNVAHGSAIVECIVAHFFWPEASRVGRLLSFTVPVFGTSVSLLLVVGFVLIIVGQIVRTMAMAQAASNFNHHVQSEHQEGHVLVKTGLYGYLRHPSYFGFFWWGLGTQLVLGNVVCFVGYTLVLWRFFSTRIKREFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCX7</accession>
    <name>A0A1Q5TCX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCX7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="885" mass="98522" checksum="36CB15801A81CB6C" modified="2017-04-12" version="1">MDVLGVSIGVVSLVSLFKTCLDLFETFENGRNLGTEYEILSTKVGIERVRLVLWGDAVGLTKLASDQQNTPNRQDGLDSRLVEPRMVRAVSDILSCMRRLFEDSGSLTRRYGLQATTTTEMIVTTNGENALSTTFHKTYARIQASASRIQRNSSLVTATRWAIKDKKRFERFVEDLRGFNDSLGLLFPELDANSRQVMADDIKESTDLNNLQIVEQAVSDLEGGESLAEAASIRITQLSQYSQSLSEGQTAQTDDSIVDIDVHRLTRQLGKLEASMSKRVELRGGLQFSLGGTVGGDCFAEYSFYGMDTEDFMVERHKEAQYVKRGVLAWSDLVQCHRLYEGKLPGTRSIDGYIADFNMWIQANNPTTERFWNTLGALPDVSFVKLVERARRAQLQGERFWSYDEPSTNSNLEELIGPAHMGSRMQDQVTELLSILNRRRDFPDVLDGASLATIALGTSDSLYSFLLLVILAHELRLRMHQLSDIAFGNISRRIVASMHASERWLDGVHLKIPDPKGKPNNVELHSLVHERQVEGLVRFAEMMAWPALGEMRIFAEEAYAGIRAGMNTSTYLWDWLYGLMLPGNAFIFAIMAALVAATPSLQHLAAAEYYNSGLVLKDRSYWRAKTVLGRVLGGMKGVRAANGWIGPCPAPVDVREEALKGGWWRVHARDVAFNRFMARDLSAYEGRFSRLHSSDEDSSTAEWIRGMGDRSEWAVPIGPSQSSDQVEFRALRFQKIGSVLHGSSSPVEDTLNPTGVDNDREPEQRAILDLLINGRLVSFTLYSSPVFITAPACIDGPHAVRQRDLPKMQHILRTSELPDHAHTDKRILIIDATGKGECELVARAWCSQNGQHAIIVRGQGTCFTCAVKAASQGGLVIGCVIWSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD88</accession>
    <name>A0A1Q5TD88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD88"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD88"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="168" mass="18848" checksum="9FDF97A997F19620" modified="2017-04-12" version="1">MFPFFQRSRGDPWQKVGFASTFPDLSLDKDCSKITPGCKAFHIPKADGSSSADGPEEANLESPGDMKDQVLVFQYKGKFHAVDHSCPHSSFPLSQASIFDIEDFGITLSAGLTCPKHEWSFDLFSGQGDRGNYKLKIWEVELREPSASSDNVSERDKEVWVRRKQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDN4</accession>
    <name>A0A1Q5TDN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDN4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28026" checksum="A77E1F8EE9F216D3" modified="2017-04-12" version="1">MPQSFLRNSFEQLTLHSGWIIHFLELIESKNFEVSDPTLGHCVAIVGTIYLQHSFVEDQNFSTKAQTGFDKCLRFLHRLGHRWPHVDQQARQLEQLRDSISSGGVITGTGATPNSRQKWSVNLQLLWKVLVYSHASKAPNPAGDIFGPELAKDSIAYSGISSTNDIAEPDFALIGSAGISGHKTVVPECVTYPPEQTEHSTQLQQELGQISPSVPIAHLAEDPSLNFVGEETLFLQMQDYGKAFEDWLSLNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDV1</accession>
    <name>A0A1Q5TDV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDV1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDV1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="154" mass="17252" checksum="14622B3ADA5943FB" modified="2017-04-12" version="1">MESELLVITISVIWMGVPFGIYGLGLLLYEHLVKYDRLRYGCCGLSVLYSCYSVQHPSAGPLFNYMTGFMAIYHPVRAIELLIVSNPLSMRRLRKVGSLYCWESFPPPNDIRRIFCIIDLLANPRAIGWSHGPTFGPNGGTTYFDAQCGPLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDV7</accession>
    <name>A0A1Q5TDV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDV7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="30108" checksum="8C33892DF4C8F3C5" modified="2017-04-12" version="1">MCSSPLIRKVIIIGAGGHLGPHLVSAFDTDPHFQVSILSRASSDCSRFPSHIPSYCVGENYDTSESELVELLRGQDAIISAIAAQAVQQQKTIINAALKAGVKYFVPSEFGHDTRNEQLAQLLPPFLVTQKRQIVEYLQSKEVEGLKWTAFVTGPFFEITTALAVKNALLEPIKATNTYLFIESFNVSQNGILSALGRLTGRWDESYQNAEEEKRRALEELSQGNFSGLPTLMRYVTCVEGCGGDYMNYEASANGLLSLPEERLESALQKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE62</accession>
    <name>A0A1Q5TE62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="143" mass="16571" checksum="07D8A9C771E3A8F8" modified="2017-04-12" version="1">MGALEVENTTRTIRSKSTLRHILCYGLSGLQNLIRTHPVTNLKSLFYNPSFVIHISELKNQEAIHTLNFLREHLHSADDLSVRWKWEPDSVAFWDNRVLVHRAVPGGYNVEEREGKRTAIYGEKPFYDPKGQSLSEWKETHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEJ0</accession>
    <name>A0A1Q5TEJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9074</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEJ0"/>
    <dbReference type="SMR" id="A0A1Q5TEJ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEJ0"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293407" description="Glucoamylase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="13">
        <location>
            <begin position="539"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="646" mass="68711" checksum="EA8A65E63196CD74" modified="2017-04-12" version="1">MAPRFWTALCALSLGHAAVAAPQLAARATGSLDTWLASETSVARTGILNNIGSSGAYAANVKAGIIVASPSTDSPDYYYTWTRDSALTMKVLIDQFKNGDTSLLTVIEEYISSQAYLQTVSNPSGSLSTGGLGEPKFNIDESAYTGSWGRPQRDGPALRATALIAFGQWLISNGYTTQATNIVWPIVRNDLSYIAQNWNSSGYDLWEEVSGESFFTTAVQHRALVEGSTFASQVGSSCSYCDSQAPQVLCFLQSFWTGSYTLANFGSSRTGKDANTLLGSIHTFDPQAGCDDSTFQPCSARALANHKVVTDSFRSVYTINSGIAEGKAVAVGRYPEDSYYNGNPWYLCTMAAAELLYDALYQWNRIGSLTITSVSLAFFQDMYSSAATGTYSSSSATYSTIVGAVKTYADGYMSIVEEYAMTNGSMNEQFSKSDGSPLSARDLTWSYAALISANNRRNSIVPAAWGETSASSVPATCSATSATGTYSTATSTSWPATLTSVSGATTTTTTTSTSQTITATGTTTTTSKSSTTTTTTSSCTTPTAVAVTFDLIAATYYGENIKIAGSISQLGSWDTSNAVALSAADYTSSNHLWFVDVSLPAGTVFEYKYIRIESEGTIEWESDPNRSYTVPAACATTAVTESDTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEN8</accession>
    <name>A0A1Q5TEN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEN8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEN8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="358" mass="38454" checksum="037C25F278F8277D" modified="2017-04-12" version="1">MDTQAQFHQSVPGNPDHRPVYADQGQYPVQNHQQPTWGSHAQMTQMLPGGPTANSTTEQYHNFPMDAQQPSQMSAYTTSIAYPGSQRSGLVQPVFSSSQPAWQLGGHHTKSSHPPQPSSDHYSLTNLSQPFYGSQPIPQTSGQHPGEPASRSSQPSIPYHTGSAHSGNQVEMHQPRGSLSAQSHGNSNQGNNIASHPLSRSQSHQSAGFQHDQQDGLGAGSHTQPSVHDYGPQLSNGQSSYQSTDMSRTQRGPGFNSMVFPTAPGAHGGPQHYQNPVVQAGVHHYLSQQPQNSTHSDVTNQHRANYHPHSSQSTVPQGQWTTSASASRIAASDPQFVSGPWASSTPPTSGPSQQLHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEQ1</accession>
    <name>A0A1Q5TEQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Acetolactate synthase</fullName>
            <ecNumber evidence="4 11">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_8970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 11"/>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEQ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEQ1"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="147"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="354"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO98719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="527" mass="57545" checksum="B1AD2DBD8F53D214" modified="2017-04-12" version="1">MAQGYSRVTGKPGVVLVTSGPGATNLITPMMDALADGTPMIVFCGQVKTGLIGLDAFQEADILSMSRPCTKWNISVRSPAELPKRINEAFEIATSGRPGPVLVELPQDVTAGKLQENLPLSPVLPRHLGTARTAINQVKKDELMRAINEVARLVNVARRPVLYVGQGILATPEGPRLLKEFAEKASIPVTTSLQGLGAFDEEDPKALHMLGLHGSGYANMAIQRADLIIALGSRFDDRVTGNIAKFAPEAKLAAEQGRGGIVHFDISPKNINKVVEATVPVVGDCAVNLRLLLPHIQSAQRPEWLSQIQEWKAKYPFQAYNRSGRNDQILPQRFIERLCQAVTPIKDRTIITTGVGQHQMWAAQHFRWRYPRTMVTSGGLGTMGYGLPAAIGAKVARPDALVIDIDGDASFNMTLNELQTASQFNIGVKVILLNNEEQGMVTHLQTVYYDNRFCHSHNQNPDFVEAARAMGVQAQACSEVTEVDEKLRWLLESNGPALLEVKVAQKALSLPMVRSGSALDDFQFYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TES1</accession>
    <name>A0A1Q5TES1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutaminase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8988</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TES1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TES1"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032515">
        <property type="entry name" value="DUF4964"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16334">
        <property type="entry name" value="DUF4964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012118060" description="Glutaminase A" evidence="1">
        <location>
            <begin position="24"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4964" evidence="2">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="331"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="73787" checksum="441731527AE62999" modified="2017-04-12" version="1">MLWFRDWKAIALVASCWTSTSDAITYSPLKPPSYPLAVRSPYLSAWIPGNEVASLSSNNAQFWAGNKLIWSVIARVDGVAYNLFGVAKPPSGTQSATVTEATYTSTHSTFTVTTGSREFILDFFSPVSPKNYLRQSLPFSYLTVTLAAGDSTSVQIYSDIDSSWTGQTSDSSWSYSTSGSTGVFQIESVGAATYSQNSDGQALWGSAVYATRPSNSSSLSTASGPSLSVRETFVNNGNLTGDHADWSSTGVVALAHDLGTTADESAVTFAIGHVREESINFLGAAQTGYYRATYADTVEAVVHFLDDYDGAKAESAQFDKLIQDTGTSSYGTNYSDILALSVRQVYGGIEVTIPNDSLDTSETRAFIKEISSDGNINTVDVIYATFPIFYVLSPEIIKLLIGPVFEYMGSSAYTKSYAVHEIGANYPNATGHPSDGEEMPIEESGNVIFLTYAYQAATGNTDLATTYSAQLKQYADYLYENGLYPASQLSLNDALGELENQTNLAVKAAVGLATYGALSGESNYTTAGKEFADKIWTDRLGTDADGTHFLIQYGTNPWFLVYNHYPDLLFSLNAFPNEAYNATAEFYPTVRSAAGVPLDGSIGWGQTNWQSFVAATVSGDTRDILISDLHTYISNGLNSAPFCDRYWVEDSGSYVAGQEYSFRARPTLGSHFALAALSGANIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF05</accession>
    <name>A0A1Q5TF05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF05"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7784" checksum="28B5061EFC55A1E4" modified="2017-04-12" version="1">MNQLVKALENVSFGAKKTQRMAWAIRDVLQALMERAHSAGTGLPWQRIAVAFTVHSSRPTFFDGEFSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFZ4</accession>
    <name>A0A1Q5TFZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFZ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFZ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="77596" checksum="4F30E562269FD857" modified="2017-04-12" version="1">MANRAAIAAIVFMYFVGIGWAIGWNSIQYLINAEIFPLHLRATGSSLLMCFHYTNRYGLSKLPHIAQRLRDRISQLQTGISTTSTDEDNSTADLLQEDVKQPDQFDERQALHRLAEAPPETTDPPILTAIEHLAWGRNSAGCFPHRRCACQYRRDNPEMLSMNSGSFQLHGSALESLIFVPISNDAQKLIKFHIGHLTWHHNCFHGETFLEQCDLFWSTGRCDNPLWIALYLSVLSCTVNSIQNSRKLKSLLDVDLDSMQTAQQLFSSMVQTLYHSHFLNNLSICSVQAIVISTEVAHNLGLSQLNATMFNAAVRIAECLGLHKIKDHPSTLTHTRDQWEERVEREVGRRVWCQMIIQDHFAIPFTDTYSISPLQYSTGRPLNADEQNLSELPTNIPTISTYVRVLVELAALMPDLVDGLGPMNKRKSRREQYEHILQVDQKMRAVVKGIPSFLLRPDKAKESKIPWLSIVRRSLAITAAEKIIMIHRPFLFRSFHDPNYGHSRRTCIAAAMTILREHETIAKEEDLSIWTHTAFAITAAVILCFEVNATVEDPSDGKIEMYREAVLSARERLALRNHDLLAQRGVALIDAILIAEEAHFGTKQRKRGGHIDFNRIFANYSTLSRVILNPDDEMAFGKFPGNSPDEFRSVDTNEMQFAWNQDEIDFDIWFNGIFTDLQPSPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGZ5</accession>
    <name>A0A1Q5TGZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGZ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="409" mass="46996" checksum="A2C3001E3A3614BB" modified="2017-04-12" version="1">MVHSLLNVTTSKKYVTYQMLENRQMLYEFLTQPQDFLKHIRRYSNALTTTMVFGWRTPTYEDEKMMQLFDGFSEFATINQTGAAALIDFFPFLRQLPDFLLPTQKKAKELHKHEKALYRGHWLKAKKQTQENTINPCFCAGMYEAQKRDGFSDDQAAYISGTLLEAGSDTTSSTLYAFMQAMLLFPEVQRKAQAEIDRVIGPNRLPIMEDLADLQYIRGCMKESLRWMPTTILGAVPHAVTQDDEYKGYFIPKGAGVMNNVWSIHMDPKRHPNPRVFNPERYEKDRQSLGDAAANPDPSKRDTFTFGAGRRICPGIHVAERSLFLGMSRVLWAFNIEPALDDQGKPIIPDPDRLTQGFVCMPEEFPARITPRSKERAEMVAREWKEAQAESLDPHTKQWIQSPVDRPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THE1</accession>
    <name>A0A1Q5THE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THE1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THE1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="654"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="909" mass="101037" checksum="B1611F58FFFF90D6" modified="2017-04-12" version="1">MAYQGSGAHSPKYESHQDAPAQYREDEDASHGLLSHQQGPFATPFDDPHSRGVSPVRPASGYSLTETYASDSAPGYHDPYATGSVYSGQSESPAAAFGVPGRVASPYARSETSSTEAWRQRQAPGGGNPGGGNLRRYATRKVKLVQGSVLSVDYPVPSAIQNAIQAKYRNDLEGGSEEFTHMRYTAATCDPNEFTLHNGYNLRPAMYNRHTELLIAITYYNEDKTLTSRTLHGVMQNIRDIVNLKKSEFWNKGGPAWQKIVVALVFDGIDPCDKDTLDVLATVGIYQDGVMKRDVDGKETVAHIFEYTTQLSVTPSQQLIRPTDDGPSTLPPVQMMFCLKQKNSKKINSHRWLFNAFGRILNPEICILLDAGTKPGPKSLLSLWEAFYNDKDLGGACGEIHAMLGKGWRNLVNPLVAAQNFEYKISNILDKPLESSFGYVSVLPGAFSAYRFRAIMGRPLEQYFHGDHTLSKQLGKKGIEGMNIFKKNMFLAEDRILCFELVAKAGSKWHLSYVKASKAETDVPEGAAEFISQRRRWLNGSFAAGIYSLMHFGRMYKSGHNIIRMFFLHIQMLYNIFNTILTWFSLASYWLTTTVIIDLVGTPSPSNGDKAFPFGKTATPIVNTIVKYVYLGFLLLQFILALGNRPKGSKFSYLASFVVFGIIQVYIVVDSLYLVIRAFTGGAPMDFVTNDGVGAFLKSFFSSSGAGIIIIALAATFGLYFVASFMYADPWHMFTSFPAYMVLQSSYINILNVYAFSNWHDVSWGTKGSDKADALPSAKTTKDEGTKDAVIEEIDKPQADIDSQFEATVKRALTPFVAPVEHDEKSLEDSYKSFRTRLVTFWIFSNAFLAVCITSEAVDKFGFTNTATTRTARFFQALLWSNAVMALFRFIGACWFLGRTGIKCCFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIA0</accession>
    <name>A0A1Q5TIA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIA0"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010191971" evidence="2">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="20698" checksum="2CC42ABA01D58417" modified="2017-04-12" version="1">MQYKALATLLFATAAVAVPASDATISSDDLLDNINLPIETETIPSGILSVIETAIPSTWAQALETDSAFQSSVLNDLLHSTYPAWYNSLPDSVKSWATAEGEAEVSALSSYFSIQPTVTPTSGSHAAGSSSHASSTPLSTGHNSTTASTPLTLTSTATHITSLSGSGSSTSSASHSGTSTSTAGAPAATGGLAIGLAGAAGVLGLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJF1</accession>
    <name>A0A1Q5TJF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0665 family protein C23C4.06c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJF1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJF1"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="38695" checksum="82DEC715ACFDF274" modified="2017-04-12" version="1">MVYYIRFLKTPRFQQQKKSVFISALICITTDLGDDFLAENVDLTASWIQHPSHKVRYQTAVQWQAGSRQLSILLGPFSPNDVAGQTAVLKIRLPDVEKDVLGEHSTPLVISGCSAPFGPGREPAEQLIRRDLNIGDNVRPLRIWEETGNSIARHIWDAALANIIFLEQVITGTGKSMPVLNQLLNSGKSNLQVVELGAGCGIVGIALATMLANCEVLLTDLPEVSDIVTRNINEASPKSSAAIKFQTLDWDDPTPNLTQGPIDLILVSDCTYNADSLPALVSVLDRLVRGSPGAMVLVALKRRHESEAVFFDLMRRAGFASLQTKVSLPAQWEQVDQIEMHCYQQESGVKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJF5</accession>
    <name>A0A1Q5TJF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJF5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44631" checksum="E71D4669C379D075" modified="2017-04-12" version="1">MIKRANMVLGPKPTKACDRDVFTSPTPLLLASVLYISALHHHQPELAAMESGYFAATCSAIAELVTPCLKRDETVESDSCTDGEPMDDSRSKEDKVFHNILGLIMASLSSEAYIDATGSWIAIAYRLWLDHCPSEMETSTPDWRGLFCGLQVIDIEHASMHMTHPLLPRQPPKSDIQRLETQHGNAFQGLADMMHYGLSHFVGKGLPTIWCSINADISGNIPAPQSSFSDHDSDVIRLWARKLDDWLVRYNGTSHLHLIQAHLQSLERSHQSAASIHTVLSQRLESSMQAMHTPPDTSSVLAFPGPMVDDSWTIFDQEIMSLANPPWLFQDPTPFPQTQKPSTQTVPDVQHGLPYDSGLLTHTAQQFSASNQWGNAEQLPGALPSTLNRIFGNENANHGNRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJT0</accession>
    <name>A0A1Q5TJT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJT0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="9414" checksum="8EB64CC440821D37" modified="2017-04-12" version="1">MPVGIKIMVLANVGSCNVPFRDAAEADLAFEACPLHLFSVCDAGSEQAETGLLLRVPPALRGMVFEGTRGRCLFAPQTSPGPNQGTLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJT8</accession>
    <name>A0A1Q5TJT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synembryn-like protein C3E7.04c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="32895" checksum="3144B97754CDAE1F" modified="2017-04-12" version="1">MDELALIDTLKLIFNVSKLYPDLAVTFSPSIPHILKIISRMEIPAKPLDGLISYLINSLSVLDLEGKKEKHFESNTLFPKFNQNCNVDKLINILDQAVSLYRPEELEEKAVPLLHSLIVVHEVAPEGPRKYMQWLLLPEDSDRSLPIGRSDTLASKLLQLSTTPYPNLKTGISELMFVLSGKDAENLTRRIGYGFAAGFLASRGMEIPQTASEAFATSDANGLDSGVNPITGQRWAAEPKDTGPPMTEEEKEREAERLFVLFERAKANGLITMENPVAQAVREGRFEELPDDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK62</accession>
    <name>A0A1Q5TK62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23076" checksum="80EED3950EE016FA" modified="2017-04-12" version="1">MALMKMIKAKGSFADLTLGTFLSEVITATIEIFGEIASVTSFGSDEPRFRAKWAAKLEGLLLLYVEPQYTGQKPNDDFLESDTEAITQACHMAALIFWLLFLDDHEYLAPFSMDVLQVLVDRLRFAVSCGSMDTWMRTAPEAHTLVCLLGTAASIKLDDRIWFSLRHGRAVSCIESRKASVLLHSWSIYDWANQRRKVKMMAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK65</accession>
    <name>A0A1Q5TK65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK65"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="127" mass="13684" checksum="5CC0EA5D29EA9F9E" modified="2017-04-12" version="1">MLSCFLIPHNSIHSLTVHLVIGLLPGKKGFEAVEIAVKTCSRYRLFGAKRSSRRPSRGQEVGDHNPPPPPAADPPVLLDPVPAGDPVPGGRPAAPVPAVATLREKEVEARERENRDAVNMDNEGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKH8</accession>
    <name>A0A1Q5TKH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_7664</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKH8"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="596"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP00733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="636" mass="70478" checksum="DEC360C53080E693" modified="2017-04-12" version="1">MASKGVVLPLLRREMRCSSSRLARATPALTVPICSPATSFATSRRQFARRSVPFLLPTQTRAFSQSVTRRSADEEGTFDPQSIERESDEVDVCIVGGGPAGLAAAIRLKQLANDAGNDEFRVILLEKAGELGAHIVSGNVLEPTAMNELFPDWLSEDNPSRFEGATPAKGDKMRYLTKNSSFPLPTPPQMHNHGNYIISLNELTKWLGERAEELGVEIYPGFAASEVVYNTDGSVKGVATNDLGIGRDGQPKDTFERGMEFHARVTLLGEGCHGSLTKQVIKKFDLRRDSQPQTYGLGIKEIWEIQPEKFKSGEITHSMGYPLPKDTYGGAWMYHFGDNMVSIGLVVGLDYPNPWLSPYGEFQKMKQHPMFREVLEGGKCISYGARALNEGGFQSIPKCAFPGGALIGDTAGFLNVPKIKGTHTAMKSGMLAAEATYSALQSENEGTVFLFDYEKALRTSSIWKELYEVRNIRPSFNSWLGFWGGLLYSGLEAMIFRGRVPWTLSHHGTDAAATKPASQYNKIEYPKPDGEITFDILTSVSRTGTNHEEDQPVHLQVKDWEAHKDLAWPVYKGVENRFCPAGVYEYVEDPSKQHGVRFQINAQNCIHCKTCDIKVPTQDINWQTPQGGEGPKYIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKM3</accession>
    <name>A0A1Q5TKM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Damage response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="43"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="155" mass="17335" checksum="1923E5BEDE46C65A" modified="2017-04-12" version="1">MSIASPINLILLSLFVVLVYWHFRPKQPVTLPRGPPPVVFRTYTPKTLLEFNGVDGRPVFLAVRGRVFDVSPGRNFYGPGGPYENFAGRDASRGLAHQSFDEEMLTKDLSGPLDDLKDLDADQLENLQSWEERFSEKYLVVGKLVAEGDPEAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL59</accession>
    <name>A0A1Q5TL59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_7537</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL59"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP00956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="57083" checksum="383877D1F2C67C90" modified="2017-04-12" version="1">MVLQDLGRRINSAVNDLTRSNSLDEKAFDDMLKEICAALLSADVNVRLVQTLRKSIKTSVNFSSLPAAVNKKRLIQKTVFDELVALVDPHAQPFRPKKGRPNVIMFVGLQGAGKTTTCTKLARHYQTRGFKTALVCADTFRAGAFDQLKQNATKAKIPYYGSLTQTDPAIVAAEGVAKFKKERFDIIIVDTSGRHRQEEELFTEMTQIQTAVTPDQTILVLDGTIGQAAESQSSAFKATADFGAIIITKTDGNAAGGGAISAVAATHTPIIFLGTGEHMMDLERFEPRAFVQKLLGMGDVASLVEHVQAITKDSSSAKETYKHIAEGIYTIRDFRENITSIMKMGPLSKLSGMIPGLSNLTQGLDDEDGSMKLRRMIYIFDSMTAAELDSDGKTFVDQPSRMVRIAHGSGTTVREVEDLLSQHRMMAGMAKRVGGQKKQMQRAQNMLKGGNNQQQLAAMQKRMAAMGGAGGMGGMPGMGDMAKMMQMMGGGQGGGGMPGLGGMDLQSMMSQMGGLMGGMGGMGGGGGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLD8</accession>
    <name>A0A1Q5TLD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLD8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013089808" evidence="6">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="439" mass="50257" checksum="1AA03628E9C77377" modified="2017-04-12" version="1">MAGLAVWLSLGVFLALYLLRQKPDARLKQIPIIRYSDFLPDLFNRLIFYPKAKSMIYWAYENFKNDPFRMLTGDGEIVVLPIKYVEELKHLPPSIISSLDAQFENALGEYTNIKVNSYLPSNTVRKRLTPSIDQWITIKAHEMFVSLISRATSRVLAHSLRRNEQWLDVASNYSVNVGITILLLRPFPNFLRPFIAPFLPSVRQMKKQLQFAKNLFIPMINERRAAEAANDPGYVKPDDFLQWMMDMAEDEQDLDAEALAHHNLILMSLAVVHTSSIALCQILYDLIARPEYIEPLREETVRTLSSGWNHATKASFDAQKRMDSFLRESQRWGPPGELSMHRIVKTPLTLSDGLHLPKGVHICFPSGPISKDPNFISNPAIFDGFRWCQDPADRDALRSSSTTSNGKTEKEKKEYQSVEHALWIWSSSLPGSVLRCEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMK4</accession>
    <name>A0A1Q5TMK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMK4"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="402"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="524" mass="59700" checksum="1F51E8C297939455" modified="2017-04-12" version="1">MPGDNSPSTAQGAKSKKNRKKNAKAKENAQQADPEQLETSENHDGTVQDEAEEDRSDPVETPDADIVKQETTEKTTPEQNVDNPNSDDAEPKDRFDALVRDRDSLRAEVTDMRKSLEEIQSKHRADMEALQQKLDDSESKKEQAETQFQKLMERVNAIKSQLGQRLKEDEEELAQARSQIEELEDENATLKSQLESKSTELAELSEESAQKTKEIDTLRDRTNLSQQNWIQEKEELIEQNAYLQSEFEQAKDAMHNWEVLAMEERSVRENLAEKTSDLEDQLANLRDAYERASGERDSQQSTVDGLQRALQEIQLARKQELRELIESSDTQLEDLRKSLREAQEQAKNADKNLLTAQEELERMRPFEKEVKEKNLLIGKLRHEAVTLNDHLTKALRFLKKGKPEDNVDRQIVTNHLLHFLALDRSDPKKFQILQLIAALLGWDDEQREQAGLARPGTSSFTGKLRVPGTPLRTPSTPNLAEFMDNGASSKETLAELWSNFLEQEAEAGDRNTMRRGSHPGPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TN79</accession>
    <name>A0A1Q5TN79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000635">
        <property type="protein sequence ID" value="OKP01691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TN79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13861" checksum="9E0E5D4573301325" modified="2017-04-12" version="1">MANRVTKNPPLRPGYYAVKLAKALEDEAKAENCSRYNDAARPLEQVKQGPFTTLSERVKRIEGGREWERKAARRLLKRELAAEIKILKSEIEDLKQVVISLQPLLSERSRGKRVAFQDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQQ8</accession>
    <name>A0A1Q5TQQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="13117" checksum="C31136E6D10A0AA5" modified="2017-04-12" version="1">MAAWGRIAAPERKLGQLPEREGPSSSSLLTSLNVQKIHYPGSTPIPSGKALFGTPVREIEYSRLGRPNTPPPPETVDTVRAGLSESWHPLYWDTAMTMTVLSHIPLRSAESLLSPLLMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRL1</accession>
    <name>A0A1Q5TRL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">54S ribosomal protein L20, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRL1"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="23543" checksum="1E174AD8D38CACC9" modified="2017-04-12" version="1">MATSIAASKRPFVTLPFLLPSWSDSLALGSRRYQSSYRRTKQRLRVKPDATFGSSYQGRDQIIYNPPSSAPSVYHTPSKFLPSNDARRSMRIEDSATGNVTDKVEELPNVYRSDPERKYHLTPADVEEIRKLRLSDPMTWSRHKLAKRFECSPLFIAMVCEASPEKKQIQRQVLEAVQSQWGPKRRMAREDRKLRREAWGRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRM9</accession>
    <name>A0A1Q5TRM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TRM9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="455"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="925"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1231"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="547"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1328"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1378"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1451"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1604"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1716"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1397"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1459"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1492"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1605"/>
            <end position="1642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP02875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1811" mass="204800" checksum="4EB6FAA54531F8BD" modified="2017-04-12" version="1">MADAQLAPSPLREADQSLENEKLKKPNPISVSNGTKLASPFPSPTATNRPASLRQPPPTGAAETEKASETKEPSKPSGATASKKENLRASSTQRGSPKDHPSPGTRLPNNDRPSSVNRHRHQPSIPGMSPSSRTPSVQFRDTDNEAPDGPASRGPSRPSSVYGEDGEQPRGRSFITRLKSLAASPPFASHSRSASGATIGDFRPVPADTVTPGSERGEFRFPEPLTEEGSDADADAEESGGEQQNERPKRKRILRRRRQTDEDLGNRTAPTTPKTTRRPSFHFSSSFAPFENYRINPFPRRASTTDFTPQPREGVSEDEGRAQLNRRKRSALTTRGFSYIGRQQQDGNQDEQQRPSQLRRLTGIGGPSENNESLAATWRRHRNERGTSASAQRWRQIKAGLKLIGQRRRPENAVDNKKSAELLAELSSAVPAALILASAFQRDEHGSKRIPILLEQLKVRVTDSRIDSHSGDRHLVFRIELEYGSGMTRMKWVIFRTLRDFANLHLKYKLHLGTQKYIQLRTSENSPSLPRFPRSAFPYMRGVRGLESEFEDEEEDGGYETGPEGMSGTERASKKKGKNPQYQRRPSQGIARRKSSITNQEGESAAAPSSTHEGAGGRRETYPERQRKKLELYLQKMIRFLIFRADSNRLCKFLELSALGVRLAAEGSYHGKEGFLIIQSSKGLDFRRALTPSLIKKRHWPKWFLVRHSYVVCVDSPEEMNIYDVFLIDSHFKMQTQKISLRNQKAKDLAKSAKDSARHPQHHTLRLENSERKLKLLARNERQLLQFEESIRFMAENTPWMQPNRFDSFAPVRQKCFAQWLVDGRDHMWVVSRAINQAKDVIYIHDWWLSPELYMRRPAAISQKWRLDRLLQKKAREGVKVFVIMYRNINSAIPIDSEYSKFSLLELHPNIFVQRSPNQFRQNTFFWAHHEKLCLIDHTLAFVGGIDLCFGRWDTPQHSLTDDKPTGFETADMPKDADHCQLWPGKDYSNPRIQDFYDLDKPYEEMYDRSVVPRMPWHDISMHVVGQPARDLTRHFVQRWNYILRQRKPTRPTPFLLPPPDFNPADLEALGLDGTCEVQILRSSSMWSTGTPDVTEHSIMNAYVKMIEESEHFVYIENQFFISTCEIDGRKIENLIGDALVERIVRAAKNEEAWRAVIVIPLIPGFQNTVDSEGGTSVRLIMQCQYRSICRGETSIFGRLRSLGIEPEDYIQFFSLRAWGKIGPQKQLVTEQLYIHAKCMVVDDRAAIIGSANINERSMLGSRDSEVAAIVRDTDMIPSTMAGKPFLVGRFPHTLRMRLMREHLGIDVDELLEHDFSTEEELRKIQVVEEGTQTTDGRERRESESSMIERQDEREMMERRHRVQDEFLSRSEHMHSFNHDVDWEQGKNPNLKSNRRLTSDPRVTDNPEHKKDVDGDGVDRLIDAEKAGLGVGRDSQMSPDGREALLSPIAAEGKGTVEQPKHVPERKPPRATSTRKDGKQSCSVENARDSETTTNSDTPSQGHTASGSSGRESAVGSGGLYVSKETQDNSTYGNPLIPDLKRIFVDKDCMKDPVNDNFYLDTWQALAEKNTKIYRSVFRCMPDSEVKNWKEYKEYATYGERFAEMQSQQGSKPAPSSNQKQNGPTSAGVSSTGLASSTSVASPRSEGFPSDLKAPQTIDEKAELAKPDANGAPQSDLAKQETLSSIDEKAALKTASDPHLLNTAQNNEDSIAVEDAEKPRAASAHVDYSEAVNLNATTSTSQSRRRRRRATTIGSKGGVHGMDEIMDKQRAEDLLNKVQGHLILWPYDWLEKEEQGGNWLYALDQISPLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUB9</accession>
    <name>A0A1Q5TUB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUB9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP03793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="37433" checksum="47BCA648571C3545" modified="2017-04-12" version="1">MKTPIFWAVLCGDREKVEALLSLGADINASDYYLETPLTVAALQGMLSMVDYLLDRGSIVSAEDIAGNTALFHVAGAGYEEVARLLLEKGANIHHKNALMETPLFWAARNGHATVTDLLLTRGTEADPRNMFLETPLLHAASEADAFNEEKYTPTVHLLVERGANVDPTYHDTDTIGVYDLLVEKMSGCAPNLKSADGETPLYRAAVLGFDDLVKLLCVHGANPNLANRFGRTPLMVAVVRGHWKCVMALLAVGTIDRDATDILGCSASSEAEGRGVPLVKGVLLGGYTNLEILEAANFQQIGFKPEQCNQERAYNPNPDDIPKISKEIWHVGDWRHVMFVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXR7</accession>
    <name>A0A1Q5TXR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-galactosidase</fullName>
            <ecNumber evidence="6">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_6728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXR7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="11">
        <location>
            <begin position="344"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP04983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="424" mass="47463" checksum="1CC36F9608A68E38" modified="2017-04-12" version="1">MSRALHGLYRNHLMRSKFVRQNRPVLLNSWEGLYFDINHSNLYEIAKESAALGVKLFVMDDGWFGKDYPRISDEAGLGDWVPNPHRLPHGLDSLVNDITALKGTNSANLWFGIWVEPEMVNPKSNLYCAHPDWVLSAGTYPRTELRNQLILNLGLPEVQDYIIACLSNILTSANISYVKWDHNRSMTEIQTPSAAHAYILGLYRVLDTITTRFPDVLFEGCAAGGGRFDPGILQFFPQIWTSDNTDAVDRISIQLGMSLAYPASSMGAHISAVPNHQNNRTTPLEFRAHVAMMGGSFGLELDPKKLLPEEKASLPGLIALAERISPVVVNGDMWRLSLPHESNWPAVQFISEDASQAVLFYFQLQQHVNEITPRVKLQGLASNRMYQIEGGGRYSGMVLMNHGLNYYFGSDYGSKVVILTKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0F2</accession>
    <name>A0A1Q5U0F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0F2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="123" mass="13539" checksum="41E8609214DE087C" modified="2017-04-12" version="1">MNDHNENCRVGPNSDACDKIHGDEDMPNFPHYEARARRSNNGPLPKAPLIRWEGPLVRARCILASSPTNCPVAALLRVYGDGFPSTFLLPAVPNRRGWYAPCPFRSCSAPLGAHYCTHGRIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1B2</accession>
    <name>A0A1Q5U1B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor SFP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1B2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1B2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000676">
        <property type="entry name" value="C2H2 transcription factor (Sfp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="455" mass="49005" checksum="D633527C5D6989E3" modified="2017-04-12" version="1">MTGTSPFTFQSPSFHSSSYLPKLEANFMRDFSCCGVTLPTLHDLLQHYEEAHATKSPNQGHRPSQGENRAAMAAAAIAQQQSQQHGNQGRGLQPDRTLDMQRKMGQPPSALQHVDLDTMDDMELDDPMGDADAATSQLFSPQLREGGQGGFGNSNQGSQLNLGMLPSHQGFNTPSQPGTPIGSARPLSLSNNPTVSSVNTPTLMANPLQNSQFRNTPDSSGPGTPAEIDESVVGGFGDLTMQQNMMGQNQVQYGRYPGNNDMVDLCIDEPAKRLFSPNGGMGTPNAHFKLSGAQYGPNSDIARRIREQQLLAGVPDTTSILPNEEPKPFRCPVIGCEKAYKNQNGLKYHKAHGHNNQQLHDNADGTFSIVNPETSTPYPGTLGMEKEKPYRCEVCGKRYKNLNGLKYHKSHSPPCNPDFQLAAGRNLNLGGGVMQGQNINVAGAGLPGIGEEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2X5</accession>
    <name>A0A1Q5U2X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000587">
        <property type="protein sequence ID" value="OKP06826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2X5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2X5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66299" checksum="BCE07C9CF378E3E5" modified="2017-04-12" version="1">MDAQDIEIDKPLTPHISEDEDGGCVSDSDIYSAEPQYLESTTLFKQPETKPVLGDGLILEVNRIFASLTKIEAKCIELVNKYIGSDPSNKQWQEMISLHRTLVYKHVDLYLASQHPSADNELKELPKSNDLPARLWFHGIHSLLELLRKQLPGSQEYMLAFFYLVYTMMTQLLERVEKYCEIWIECLGDLARYRMAIEESDKRVRDVWAGVSRHWYNVVADRSPEEGRIQHHLAVLARPGLLQQLFHHTKALVSVRPFAKSRESMIRLLSPYNAQDALDQDTIPAAFIATHAALLNETPSDQFITLANHFLSLLREELRSEGYDGQTGVYIMSCNFASLLQYGDPKAIMAIKFGKKEYVSVVAPCKISPNLRPTLDRKNRTKKDGEPTDLSVHLPPMMARGSALTFHTLSVLLDNHNPKTYAGAHISMSFVWSLAAHPATMQQVYKVIPWAKIVRFLNSLVGPETKFGKVEDRAFPLHDGVACQLPEDFIIRGQSWSQHYFPSNFFNDAPPEAERYVASLYQDYVMYPLGYQRGEYTHHGGRQSQIEDKGQHVLQESTKQDSGLEGKQQMWLTRPGMVSAKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4J9</accession>
    <name>A0A1Q5U4J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4J9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4J9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000786">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP07390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="560" mass="60462" checksum="48B07086BF046069" modified="2017-04-12" version="1">MASEDPFVNGLEKPDPASAMSNPGSIVARDQEDSDRKAEKFALGRRGQLVFFTLAVLTLMAALDGTSLSVALPPSNAKAVFQPSFASLSNIFGRRPMVLVAILFFCVGAIIAAVGNNFTYMLVGRTIQGIGGGGIIALSEIIVTDLIPLRYRGQYFGILSAMWSLGSVTGPILGGGFAENVTWRWIFYINFPFIGFGVVFVVLFLRLSILPSSLVEKLRRIDYVGTVLFVGSMSSFLIPLTWGGVSYPWDSWHTLVPLIIGAAGLFVFAFYEYRFAADPIIPPKVFRNRTATVSFIGSVLQGLILWCTLYYLPLYYEAVKEYSPIISGIALFPETFTVAPSGMAAGILITITGHYRWAIWLGWVVSTIGLGLMCIIKSSTSIPGWILLNVVPGIGLGLLFPSLGYAVQASATSENLAIAVAMFSFFRALGQAVGVAVGGVVFQNQMRNNLLKYPALAPMADSYSQDAAGLVQIIKGMADGVNKSDLKDAYTDSLRIVWAVCCAISGVALLLSLLTESYDIDQTLETNQGLRDPDENNEPTEKDLEASAGNAVQKTTPWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4V2</accession>
    <name>A0A1Q5U4V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4V2"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="111" mass="12524" checksum="2539E613CDFD380F" modified="2017-04-12" version="1">MSQELEVTLRIDYYCDCVTQGDFKAKLDTYGWKLRAFDVDSWSSLEWSSSDSGSFKNPHKVSPLSLENLSTPSPLTRYQSSSCYGAIQAIQAIEAIQNQHVDSPFLPRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U743</accession>
    <name>A0A1Q5U743_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U743"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U743"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP08299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="38048" checksum="B862194D7AA3287B" modified="2017-04-12" version="1">MAHSPLFEEYKANRTSHVLVTGSTGFIGAHVVDNLLARGFAVRGATRSAKKGEQMKAARPQYASKLDFVVVEDFTNVGVFDAAMEGIDAVIHVASPFFYDTTNNEQELILPAINGVKSILAASAKPGSQVRRIVLTSSFASVVDIDSNPSPDFTYTAAHWNPLTYETAIDPESSSVVAYRGSKKFAELAAWEFVKNEKPQFDLVALCPPMVFGPVVHPVPNIEQLNESNAVLWSVAAGVDPLPGVRVPAWIDARDLAEAHVQALLTPEAGGKRFIPASPEPFSYEYAADIMKETFDWANASVTSNYKAGEKPHAPYGVDGQTVARELGVKYHSFRDTVVDFTKQVKETLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U791</accession>
    <name>A0A1Q5U791_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U791"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U791"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="127" mass="13758" checksum="44F3F5707FE5F205" modified="2017-04-12" version="1">MNQVHLGYTSWNDPVTNTNVMPALNYVADPEGVQGIGVAVQGRRNTTSTYSISSDTSYVKVSQERGSVSSQGHGSNVRGFITVNWRSAKPGLSYTELTVRARDGSIAKLLLPVNKTVVPPGFTRFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA62</accession>
    <name>A0A1Q5UA62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000531">
        <property type="protein sequence ID" value="OKP09363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA62"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7185" checksum="97BA8A30E12D01DE" modified="2017-04-12" version="1" fragment="single">AENNRLEQALSHTRNELENSTFENSNLRNELLSSQVRIAKAIQVLEVTAGKTATESPEDLQMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAE8</accession>
    <name>A0A1Q5UAE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAE8"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="277"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="432" mass="48550" checksum="59C3CB5391585F25" modified="2017-04-12" version="1">MSLPARRLINQPWSRRPQLQLGLRGNHLRFPRRLHARAKEYLQAHDPDLTDSQRTVREAIVKICANYPDEYWLKQEEKKEFPIELHRKLADDGWLGICIPPEFGGSGLGISEAAIMMQTLSESGGGMTAASAVHMNIFGLEPVVKFGTEEQKRRWLEPLVRGRERACFGVTEPNTGLDTLKLQSTARRDGDHYILSGQKVWISTAQNAHKILILVRTTPLDQVSKPSQGLSLFYTDLDPSIVEITEIPKMGRAAVDTNSLFFDNWRVPATDMVGQENEGFKMILHGMNAERILIAAEALGLGYAAIRRAANYAGDRHVFGRAIGQNQAIQHPLADSWMKLEAARLMIYHAARLYDEGYSSGEYANTAKYLGAEAAFQACERAVMVHGGMGYAKEYHVERYLREVLIPRIAPVSREMICNYIAERVLGLPKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC79</accession>
    <name>A0A1Q5UC79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF187">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="154" mass="16882" checksum="DF964A625EBCFD57" modified="2017-04-12" version="1">MTVPQPSNGSTAKPTGIKVLIVGAELKSLGDIISFGPNAGRIYRRWSNGAIADRLKPLSINLENHGFKIHKWTGELVHTQRTPPADPEAPVFNGHRGELHTVVFNYAKDELGIPIHLGQRVSKYFEDENEAGIILDNGERVRPTLSCFGGSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC95</accession>
    <name>A0A1Q5UC95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC95"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="2">
        <location>
            <begin position="17"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6314" evidence="2">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="214" mass="23757" checksum="1D627491EFAEBCBA" modified="2017-04-12" version="1">MSPSRQLLPLLSSLGSSRWALTRTLRSDNPLDLNGELRGTATFTPIPNTADRDWVYSEEGEIPSSVSGGAAQVGLRWTKKYIWRDGDAGRISVWFVKIAPGPDEADYLFHNFDFADATIKPEVSSQGEEQGKETEEGKAELITPPTPPAITTTDAETTVLMARGNHLCINDMYRTAYAFRIQSETGEVLSWASRHVVRGPKKNQDIINRYERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCG2</accession>
    <name>A0A1Q5UCG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleus export protein brr6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCG2"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="240"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="470" mass="53400" checksum="C668F755FFACF60F" modified="2017-04-12" version="1">MMESRTESGGVIPMDYEWHGGSAGPVDFTSPFSQVRKQPQQDNKKRTHQIFDSPEKPAIPALRPPNSQSSFLFSPQRPQSQTHASVFGQPAFTTPRKLDVDFSSGAENLSSPEVADNEETPEQQSKGSRRNSLFNIYGRFAPSPGRGEIPRTNHYTNAVARRIHKRRRRDKALGRRVRVDDEYDDDESDRDRPSSSEGRPGRTGKQEKTPNVQNGGPGKMSFFKQLLTLLEEHPNVPAILSWWAQLVVNLSLFSLAVWMVFSFVSEIRNEFDAVASKEMDSILHNIAECMQRYEDNKCAAGNLVPGLVPICAADRKCMDTDPTHVRRAMLSARTMAQIIDSFIEPISWKAIIIFLATIGTVAWASNWSFRSFRNHRLNHGYPQHDYPPPPSYNPNMHGQPLHLQQNPAYGFYGQQDHPRASPTKNYAEREDAPLMLENTRSMDFVTERSREREGHLRTPSPSKRMHRQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCK2</accession>
    <name>A0A1Q5UCK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCK2"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF77">
        <property type="entry name" value="MEMBRANE STRESS RESPONSE PROTEIN (IST2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="174"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="674"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="740" mass="83865" checksum="7146F2102ED9AF59" modified="2017-04-12" version="1">MSWLAGHEKHGHDESDNLGVDWVLQYEFGDIEQAQAISEFRTLIHDLTEAGLRVQIRHGHGFALLVFIRVPRDHLGKMVHQSRIKDWLFGIIYTLPSGDENTIASAETPAEEIRSIYHAVTWRKELGGAGITPGFGKWKNITASFPLHDRDACSELLSKWNRKTNLTVEDLDTIRALFGEKVAFYFAFIHCYSLFLVAPAAMGIVGWWFLGPYSIIYGSALMIWCIVFVEFWKIRETDLSVRWNVKGVGQLKVNRSQYQWEKEVKDPISGQVTQTFPGWKQFLRQMLLLPFASVASVALGTLIVVTFASEVFISEVYNGPLKGYLEFVPTILFSLSLPAITSFLTGIATRLTDYENYRTQDLYDLAQTQKTFVMHFITSFLPTILTAYVYVPFGHAIVPHLDILRRVGINTASHKGFEVDTSRFQAEVIYLSMTAQVFSFAEEIVLPYVKHVLWQKWRNYRERKAGLTRQRSFSKATDLLLIDSPEESSFLRRVRGEADADEYKVEEDILEMCVQFGYLALFGVAWPLVPLGFLLNNWLEVRGDFFKLTLECQRPPPIRADSIGPCLLGLDFLSWMGTLSTAAIVHLYRGPMSSVRLSSLLLTVFIAEQVYLGIRFTASTALQKIFSDTLRREEASRYAVRKSFLEMNQSRHGGPDSPSRVRQRVRFHERVNVYSSDTASPDGSPSPTSEQPQDEVLRGSDREAGFWEARECDTADAGVKLIRALSGGKGVGEVKEVKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCS1</accession>
    <name>A0A1Q5UCS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000372">
        <property type="protein sequence ID" value="OKP10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCS1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="25166" checksum="8B9BEEC7F559B1ED" modified="2017-04-12" version="1">MLVVGGLYKDPSFCLEGGILQTFSLNDLEFQTTYSPELVEEYRVPNVVTRQIGGTTSVATTSSSSTTTPHSDAQEAHWIVPVTVGTVIPVAGITCTIILWVLLKRKHHLRPGQCRCSPGKRHWVHKFCPGTNQYLPGEIEGNPIEPEATRPVRTLSDMISELPAPCLPSRNSNDFSIAATPVQMYCDANLSYEAPGNDKLVELSSEAYDYPSDGAKAEDCDGKRSPLTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCZ7</accession>
    <name>A0A1Q5UCZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCZ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCZ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF6">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="452" mass="51788" checksum="88C0FC51D6C9118B" modified="2017-04-12" version="1">MDNGTASLASQSLSDAARALLDAAPRQWLPYTLGLLVGYPLLTTALRYQRVRSMYKKYPYATREDMAKMTDDHAYEIQKAVAQLEFPFMFIKALQFALFRTYGIPTISHLLTKTSQFSSPETSLKRYTDTSALVQEMVGNNPTSQRAFISFARTRFLHSGYRASGKILDDDMLYTLALFALQPINFINRFEWRQLSDLERCAIGTFWKSAGDALGITYEKLPSGSSGFKDGIQWLEEIEAWSEEYERKCMVPDKTNRETADQTTAILLYMLPKALHPVGLQFVSFMMDDRLRKAMLYVSTHFPVTRSSFGDEQLTSLLPSYDAPSSIAIVVFTSLLTIRKLFLRYLALPRPYFMRSISHTDKPDENDRFFLTQWEAAPYYVKPTFWNRWGPTALLTRVLGRPVPGDEGDKYYPHGYSIQDVGPKYFEGKGRKAIDEAMEEFKGYRTGKCPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD64</accession>
    <name>A0A1Q5UD64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen-like protein V6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000350">
        <property type="protein sequence ID" value="OKP10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD64"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF417">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="242" mass="25551" checksum="23AFA3178E8E1EDF" modified="2017-04-12" version="1">MTQVFDCMVIAAIPSALLSIFGVVLMAHPRLLQDDKATAIYFACTQLILSVVVLFIGGYVANSIRGYQTLFEEFDVRASHLPYYGMMYYGGIGEAVFGSLDVCRHYYRVDRVDRVGEDSEDGENGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDGEDSADTNPSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD92</accession>
    <name>A0A1Q5UD92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1066</name>
        <name evidence="1" type="ORF">PENSUB_12541</name>
        <name evidence="2" type="ORF">PENSUB_4113</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000734">
        <property type="protein sequence ID" value="OKO92962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000323">
        <property type="protein sequence ID" value="OKP10456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000152">
        <property type="protein sequence ID" value="OKP13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD92"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="274" mass="30324" checksum="BDBA937A8F630C7B" modified="2017-04-12" version="1">MEAVMTINQGQDRERLSLRTLSTSPTAATAQDISTTSGPGLSESLFASMLPSLLQPCHPQDQILASEPVFPFKNWSMEQIFQSDSEIFVQPSPRDLITDFPGMLDEGFTVPDQSPPQSDTRRSVASFTLEDTDYTLVQANVARLDPEGRLSNFQFPSKYAVVRFVKAFFSHMASNLPIVHGPTFEITAVPCLLLCWYLRAKKSCYPALERNPSVEALIEECAAELEGLQSITAGQEEVLPLAVTAELIQEDSVWQYGIICPKKLKKNATKTNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDS1</accession>
    <name>A0A1Q5UDS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDS1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="23170" checksum="CF95C120F767F3E6" modified="2017-04-12" version="1">MAGPVDHLREWECDHVLPGTLGCSASNSCQLCPTSPAPSVRMEQQPVFSVISQAYPNPNFYHLASEGGAMGVTTPWRPRIQGRDSNGAMLPNAPHQSIEIRPQEPHNPGYPTHSPSHEKRPPQANTEPGRPRQNPDPHGTATISILYYCRWEGCPYSGTFNRESSLIRHLRKMHITPGAHPCPMPGCTRIYNRADTLSQHLRGVHGMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE52</accession>
    <name>A0A1Q5UE52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4334 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE52"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.580">
        <property type="entry name" value="GXWXG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025568">
        <property type="entry name" value="DUF4334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14232">
        <property type="entry name" value="DUF4334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4334" evidence="2">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="19021" checksum="0DF6DFC0740B83F9" modified="2017-04-12" version="1">MALTTNPKILSPSHIDSVFCDLKPILPEKLIGEWDGFVLGTRHPFETELEKFNWFGHTFDSTKDVAPLFVFRNGRHVPYEDWGRASVSFLGGSIQENCMFEAWLMYSATQLHEIKYQGTVSAALIYDDHPVIVYYRAVRPDIVAGIMESKKFGRSGKFYFYLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEL3</accession>
    <name>A0A1Q5UEL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein transport protein sec73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UEL3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="415"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="711"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1410" mass="156172" checksum="A91A3028B2CAA060" modified="2017-04-12" version="1">MHWKGLRLVADGSSKRQSTIESQPQGRRSEHLPRPLAPINEPRYSESTPRFSDLADSEGIHADDGTVPRLRVPRERGPEAGVARADFAAGPSTGDTPSLRRNRFSFMRLRHASDPQLSKSYAKGEETPPVPSLPPPKIITTAPTSHELDQPVKQRHKLRLLPSSRKHSMEELSRNSGDYHRRLERKHQGSTDSHIADSGLSTFQTSTPEEPGRLSTTSIRSGGRDQAFNESQRSSVSVTDARFSESSRSDQSYGDQNFRTNSPRDVQGSANKRFRMPRLKRHRSPLFPLPPKLPPSTNKFPPVETPRSEGSDHDQISPLPSPSRSAVGLVGPNAPPLLRNNSTNSNRSIRSNPSHKGRGRSSTMGSLAENHVDDISPAPYLASSGRTSTSTSGRKSFGDIFSISQRLRQNSEPPNPRNGSPGIGGAATPIKADLPPIPDREEGETPAAYLTKLEENLPRGMVGGVLAQSDDEFYKVGLRKYMRSFSYFGDPIDMAIRKLLMEVELPKETQQIDRFLQAFADRYHECNPGIFASTDQAYFIAFSILILHTDVFNKNNKRKMQKPDYVKNCRGEGIAEDILECFYENISYTPFIHVEDANLRDRHLAKPRRALFKSTSSDHLQLMAREPVDPYTLILDNKLGTLKPSLKEVMDLDDTYDHVGTNGPPDIDDLHQAFTKSGILQIISARSRPDAFMQSSLDNPADSHPGLVDIKVAKVGLLWRKDPKKKRARSPWAEWGAILTFSQLYFFRNVTWVRTLMAQHDAYVKNGRKGTLVFRPPLAEFKPDGMMSTNDAVALLDNSYKKHKHAFSFVRHNALEEVFLATSEPEMNDWINKLNYAAAFRTTGVRTKGMITTNYEGQRYRKSQRMGSISSLGSHQSGDKEPESPSIDNDIVAEFVAARRRLMSQKIRDTNEKLFVTQRQLDDLLRNARHLQVLTPVTPRARENVIMAAARMAAKLKWIRQDIWRNKCYREVLLRDLGEAETATEERTGSVAGQTVSTQADTARVASVSGPSIASEPSVRGTPSIVHVVTNQDAPTESAVVPAEKPWIDTGLLSEPSTEDMRRPSIPTSTTSSDLGRVGRPLSIAIVSEGRSDSASHLEREASVLSRGSKFDGASLGSRASKITSPVSFDDSEERLLRETGLLDLGGSPPPRKPSSAVLEDETESKPDESSEVSQSDNRPSRVRRSLHRTLREPHHVHRHHSRHKKNRDSVSSLAGPEDDGSESSGLPRKTPSFTVHGKKASIVTFGSEWQNMPPEERLKLRKPTPHEEPRASDPVLVGSGESVTSDNMPADRRHSYMSVSTTTGLSLRSDDETIDFFKDAQETLPADSPKRPISQVLDHEPEQTSPPEPTEPEPENEPPSTSGTGSGSITYGSHLIAPGETTSPSSTSLSERIVDTPSSENLRQQAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEX2</accession>
    <name>A0A1Q5UEX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEX2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEX2"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="256"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="41363" checksum="B15E84376242067B" modified="2017-04-12" version="1">MLALHAQDASSGLKLKQLPVPSLGPEDVLIKVYSAGITPGVMKLLKMGQSAVPTTVGHEAAGVVEALGENIKDGLNVGDRVRLHPILSCGECHQCQLGFDSMCDEAAQMGFAKFGERTGLYAQYHDGALAEYVRVPRRFVDRLPDNVSFDIGAKLHDAATALRVLKLAEVTKPNSTIILTAPTGTMGTVTLKLVKFFPNIKKIILVGRSKERLESIQHLTEVETVVFPISAPSQDSKPSSGPPGESIPGPPQPSPIVRQLRELAPEGISAIIDYVPAGPTLSQILPALATRGTIVHMGGSPAPLQIPLVFIMSKAWRLVGNRAHTRDDAQEILDWLQSDQLVISDLITHRFPLKDAHRAIDAIETRDEHVWMSIIEVIPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFC8</accession>
    <name>A0A1Q5UFC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3203</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFC8"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="233"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="574" mass="65830" checksum="E4B7E17DAAAD6419" modified="2017-04-12" version="1">MESDNADWELEEGLPQFEEPFIQQYLKGRDALIAEEQKRRHDATYRKSLSPIAARACKIVSQIRAREQSEVWTTGLDPTIAHEADEILYPGVMFHHAKGRMEKTNLWKIVEKMPKGSLLHAHMDAMFDIDFLIDQAFSTPGIHILAPNPLVSSQDFEKGPVFFQFSTQSTAESEKKPSIWAEGYEASSLIPIKTAASSFPNGGEAGFREWLRSRCMLMPEHSYHHHHGVDAIWAIFTTTFPVINSILMYEPIFRACFRRMLGQLADDGIRYVEFRIAFVFAWRKEGKDQPEDSYDDWCRTVEEEVEQFKQTEQGKSFYEARIIWTTIRRFGNKEIVDTMKECIETKHAFPDLICGFDLVGQEDLGRPLKDLVPVLFWFRKRCAEEGVDIPFFFHAGECLGDGDETDHNLFDAILLGTRRIGHGFSLYKHPLLIDLVKEKKIMVECCPISNEILRLASSIKTHPLPALLSRGVAVSLCNDDPAILGHGKNGLTHDFWQVLQGLQNIDLAGLAMMVQNSIRWSCYEDQSSGEWKHDVEQGILGEGLKAARLREWHTEFEKFCEWVVLEFAEFDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFI7</accession>
    <name>A0A1Q5UFI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein SEC24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein transport protein sec24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PENSUB_3262</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFI7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFI7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="21">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="22">
        <location>
            <begin position="314"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="24">
        <location>
            <begin position="561"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="23">
        <location>
            <begin position="655"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="20">
        <location>
            <begin position="784"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OKP11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="919" mass="100542" checksum="751696E18ED32A7C" modified="2017-04-12" version="1">MAAPQGGYPPQEGYAQPGYVSPDPTQQQQSAVPPQGAPPTGAAAKKKRAYAGEAFEFGSGANAALGGQPTAGGAFGGYPQQPQAAGYQQPTYGADPAQMQPAATGYAAPVDNVTQMTQQFGGMGMSEPHHMPPAQPQPAAQPQRNVQLNQLYPTDLISQPFNVAELDYPPPPIILPPQTSVFESPTANCPPKYMRSTLNAVPTNNSLLKKSKLPFALVIQPYAALHDAEDPIPVIPDQVISRCRRCRSYINPFVTFLDHGHRWRCNMCNLTNDVPQAFDWDSTHQRPADRALRADLNHSMVEFVAPQEYMVRPPQPLVYLFLIDVSYASVTSGLLAVIARCIKESLDRIPNADRRTRLGFVAVDSSLHYFSIPRDGSPSSDPQMLVISDLDEPFLPIPGDLLVTLSECRENIETFLDKLQTMFQNTQNNSCAMGSALRAGYKLISPVGGKMTVLSASLPNIGHGALTMREDKKVLGTSKESALLQTANSFYKSFAVECSKAQVSVDMFLFSSQYQDVASLSCLPRYTGGQTYFYPGWNAARSEDAMKFAREFSEYLSSEIGLEAVLRVRATTGLRMSTFYGNFFNRSSDLCAFPAFPRDQAYVVEVAIDETVAKPVVCLQAAVLHTTCNGERRIRVITVALPTTTNLADVYASADQQAVATFFSHKAVERALSSGLEPAREALQTKIIELLTTYRKELAGGSVSGSGLQFPANLRGLPVLFLALIKNLGLRKSAQIPTDMRSAALCLLSTLPLPLLIQYIYPKMYSLHDMPDTAGVPDEQTGEITLPPTVNLSSGRIASYGLYLIDDGQTQFLWVGRDAVPQLIEDVFGVADRNQLRVGKTTLPEVDNEFNQRVRAVIEKSRDHHSKGVGSMIVPHLYVVREDGEPGLRLWAQTMLVEDRADQSVSLDQWMTTLREKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFR9</accession>
    <name>A0A1Q5UFR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFR9"/>
    <dbReference type="OrthoDB" id="4219928at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="557" mass="61809" checksum="423D514003425502" modified="2017-04-12" version="1">MAAFGLLPSPPISESRPASTGPEASYFECKSEEKFAEQENVESTEIISEVTNSTDHVDLPPDPTEETITEETSPYQAYRPSDWQVKSPEKRRTDVTNVHEAHSNLIRQCEETLAASPTAKKPDKEEPTPVKSPASLHSATASMPTTSPRPQRPRATTVSSEASWIPSNFSYCETWLQGVPLDPLDKDDNPKEFNRRKFQIIEQDPPMPKLDIIPGARTLDEPVRFAVASKPRLVDIARQSSPSMGPMGPPPPPPIVRQTVCVPMTPDQRQEEVSAFSPDTPLDTPMDMSDSGYGTRESGYSMDSYQDSKDDDTYSDPGSLTSDSFTSTVIGERPESTLGEREISPQPEIRSGSVSPNASPSPSSHSPGRTSHTSEEEKRDKQPSWDHQWTLDDHEWTLGELDHSVKDFPRHMLRLTSPVIVFLRKNDEKALLRPFRTIFPTVAENLLDCLCAALIARNYLLSLSKLQRRRPSLSSRNDVYAVDAVPAKAYSTLGIQLPTASPGRIKDRMLDSHTSELRLDVERIIDNLLFAICGRSDTTLKAAIEVLAQVLETNAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG15</accession>
    <name>A0A1Q5UG15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">EF hand domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG15"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG15"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="839"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="885"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="964"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="992"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1141" mass="128428" checksum="3C9893C3986C1FBF" modified="2017-04-12" version="1">MSEPGSGPVSLTRYRPFLYLFTGVAAAYAFLYIRNNIVSSEPSSQAPLQRRNAVRRHRRSDPEPFRLVDTPSYRAITHLELLERQNGVYGTFRIETEDGRRVESGLLPSLLATRDQLMEEVNVPEAHAERMREMMEDTFLESFLALDFPSVHTLPENSAERTYLTEQLERRGISRAGIERALTRFNADDNYGDELRRRRQNGERVTLSTSTFPDVAAPPPNPEGREPALVDDQSVFSWRDGNNDSSPSREGQNLLNLLYHIAEDQARRDGYIHRGVTCNSCGAMPIQGIRYRCANCIDYDLCETCEAMQVHIKTHLFYKVRIPAPFLGNPRQSQPVWYPGKPNLLARSLPRMLAKRLMRETGFENTELDALWDQFRCLASHEWADDPNKLGMAIDRKTFDRCFVPNTSIRPPPPSLIYDRMFAFYDTNADNLIGFEEFLKGLASLNNKSNDERLRRVFRGYDIDGDGYVERKDFLRVFRAYYTLSRELTRDMVAGLEDDFLEGCARDVVLGSQPISSAFPGSIPSGEVSRIGEGKRINPEGDMEIVDNGGILRQDGTDTGNRHAVIGDASVRGQFGRTRPLFPSTLRLPNTATEPQQPDPTQDDDDDDDDDDGEDASDSDGSSSSAASGNWPPREHIDAEVIIEALGTYVPPEEITDPVDRARIVTVAYNRMRDDDQRRIEETRRNGIDERWRRREFYTDEEDGATIPEGYQRDPTFDDDLSDEASMDEPSAVESHPPSPRSRSSSKVRFEDDIADDYDVRSNPSTSSRSIPVGERWGGFEIPEVERDVGKEILYQVTQQGFNELLDVLFKPKEDLMMEVYRTRADRKTWAREIEEFEVSQGRKTSPTAKDGVAFPKDEEHPQEMTDSRSLDDLLSRAGYAVHSPTLEPADAQPVLAPPLADGMSPDDDVTPTHLANPDDEDGLGQNQPFEETEDDDETASMTSSSDMGAHIRPSEYASFAESLDVESLDVEPESSFGEALGYDPTLPQFRPDSDSTRPRLSFRDEPMVMADDEDSASTPSDLPNRLRLEPNNTISLPAPSSPHSSSAEAEETAPKPPPSPMQPLPPPPQSTTPPHEAAVPRKPTPRTLARWVELNRVEREAKERGGRGAKLSFEEFSRRMAADKGRRLAFVASWIEMASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGV2</accession>
    <name>A0A1Q5UGV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGV2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGV2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="255" mass="27921" checksum="ECCC3DC59A26E4CC" modified="2017-04-12" version="1">MSFSGLPTEIYLIIGTFLGRRSAINSVCQANRRLDHILNQNLCRDDVRHGHHRALFYAAETGNMAGPVNADTRDSTGRSSLHFAAENGHDEAVNLLLATGYVDVNARDRWGRTPFELAARRSHEAVVKLLLDRGHVDIKKADLQGKAPVYWASFKGHATVVKMLLETGPVDFKKKTSGGRTPIIAAAAEGHTTILKMLLETGQLEPDAKDHKGLTPLLWATIQGHAAVVEVLVETCQVDVNGKVCRDRTPLYLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGW5</accession>
    <name>A0A1Q5UGW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9578" checksum="838BAE91093F67AA" modified="2017-04-12" version="1">MQAYPHPSEKDQSKALMEIYETVVPHYLSIWCCFVAYVVTISASSDEPISALTDIGTLDLDLNRRNMSAAFHRIYNAFYDTGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH67</accession>
    <name>A0A1Q5UH67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11831" checksum="DE6D6AE24244352E" modified="2017-04-12" version="1">MADASADWADRLASDQALSSDEEDFVSSQSTASADPETRDQKHLPSALRNLHLDTSQHSSQTSNQNLTRTSTPGASASNMGTSEMTPEKKKMELLDLPLDVLKDIVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHW6</accession>
    <name>A0A1Q5UHW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHW6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHW6"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012343795" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55392" checksum="2F68FC9B3FF72B5A" modified="2017-04-12" version="1">MKPGVLLSVILALAILSASPATASASTPSQEALSKPPRKTDPRKCDCFTVTGPDPGYFQHYKLWDFRSVPLAKQADVDFSEFEDDELDQLADGKNDYDEDDDDADDDDGDDGNEDDDGSDQDDNDQHDVLWFFETAFDKDWMSQRWQRPRTDEAPIPMVNSKHNVFFTRNRQVLHRFATYLVMRTTRRWNYTSTSEIETKVRSIFHCSLRVRLRVLPSNLYVSLPESVSRGNQSVAFNETASLKEAKPHPGACVGIFTYRAHNCESDIEILTKDPPYRVHYANQPDYDAVKDAMIPGASTVADLPVHWTTWSTHRLDWLSGISRWWVDNKPQDAKTYRVPDLPSRLVVNLWSDGGAWTGDMRYDESVLLAIDYIELAYNVSAGSSQHFEIPPSEQHGAHQNSTTNISIPDVDGLRDEFSEPGAEIIDGSMMKKCKKGRKGRKCRKNRKKKHSKHGKKPKHPPHRGSSSRCERACNIDDLRFANGGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI87</accession>
    <name>A0A1Q5UI87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Caffeine resistance protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI87"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF24">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35815" checksum="2D753FDA5238E293" modified="2017-04-12" version="1">MLNVFRLAHDILGPDGYHRCRMDPPRHYSARDTTILQKKAKRARMQMKKESLRSAESTVDVNASGRKGLHELFAITLTRPFRFLFSEPITTFSVIYNGFLYILVYLFNETIPLVFGAPKGHPFNVGQQGLAFLGMAICLIVAFCLYPLQERYYLRQVAENGGKGVPEARMWMARGGAMMIPVSLFWFGWTSYRSIHWIVPIIASSLFGAGIYIVILSILNYIVDSYPTYSASALAGVILVRNVVGAGFPLFATQMYENLDYEWASSLLGFISILLVPILFIFFYKGKAIRLRSPWAKEHFDQHEDSPQGSHKMGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIL7</accession>
    <name>A0A1Q5UIL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="553"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="640" mass="71798" checksum="D7AE7AF12CF3849B" modified="2017-04-12" version="1">MANPTSGYSLPRGSGIVTRRPLILQLINKTPAPQTNGDNKIETTDAESNVDEYGEFLHIPGQKFFDFNKIREEIVRETESKVGRNAGISPVPINLRIYSPNVLTLTLVDLPGLTKVPVGDQPKDIERQIRDMVLKYISKPNAIILAVTSANQDLANSDGLKMAREVDPEGQRTIGVLSKVDLMDEGTDVVDILAGRIIPLRLGYVPVVNRGQRDIENKRPIAYALENEKNFFENHKAYRNKASYCGTPYLARKLNLILMMHIKQTLPDIKARISSSLQKYTTELAQLGDSMLGNSANIILNIITEFSNEYRTVLEGNNQELSSIELSGGARISFVFHELYSNGVKAVDPFDQVKDIDIRTILYNSSGSSPALFVGTTAFELIVKQQIKRLEDPSNKCISLVYDELVRILGQLLNKQLFRRYPQLKEKFHAVAIAFFKKCMDPTSKLVKDLIAMEATYINTGHPDFLNGHRAMAIVNERAQAAKPTQVDPKTGKPLPARAQSPSLDTTGEAQNQSGFFGSFWASKNKKKMAAMEAPPPTLKASASLSERETSEVEVIKLLITSYFNIVKRTMIDMVPKAIMYTLVQFTKDEMQRELLENMYRNNELDDLLKESDYTIRRRKECQQMVESLGRASEIVSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJF2</accession>
    <name>A0A1Q5UJF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="366" mass="40700" checksum="4D114C43D4B34A2F" modified="2017-04-12" version="1">MAAGEQPGASDAHEVSTIKVTMKMRARTLILKNQQNDIIRESSSPEPVVRPSGRGLPRSPRLPRRWTWRFRMPSQHPMTLRSHTRGIAATAAARSVLAGVQPPSRRTKVQTPRGKFMKFYILHWLSVVRRKESPVIVVLPSPHPAPAKRTGTLHRHILILKEVADTETENEAGRVLGNPVTPVRPAGRARFLDLSETRKVEVFEDTESQDTLEALTPVLYSGSSENKENDRNNLNVLEPEEEPAPPSSDVDTPPRNNHLDWSVLEAGPRDVFGLPFNFPTPLPDTTITTVVAETADITNPPPRPNLQRTVWPGDDETGDERYETNSEIAVRELLETGYFDRVPNNAQQIPVRGGQAQAQTQAAPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL67</accession>
    <name>A0A1Q5UL67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose 5-phosphate isomerase GutQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="69"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="440" mass="46220" checksum="59865B0EC5A21699" modified="2017-04-12" version="1">MSPDATQRPLTPPDPLSPPPPTASKEETSPVLTALHVMSTERAALTHLEHLYQTDPRAQQDLARAVDLIAHTVREAGKLVVCGVGKSGKIGQKIEATMNSLGIYSAFLHPTEALHGDLGLVRPNDTMLLISFSGRSPELLCLLPYIPTTVPIIALSSHTEPDACPLLSLHGPLGMGVLLPAPIHEQEEASLGVSAPTSSTTVALCLGDALAIATARKLHTDPGRGPADVFRSYHPGGAIGAAAAAAGATPSTTPSSGVSTAAFDSPSSSISLPWEEFSNGSSIPPFNLQQPPEHRSITSDMIVPLDQIPTASASSAQTASDVRLLDILLTAIQHPNAKSWVFLSASELVPPRRIRSLLSRNTDVDLRVSDVVAQDSGQPLAVSRANWFLVAESTPLTELRRLVSTSRDGPDPISVIAVLKDITSPASCIGVMEAEDLWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULA1</accession>
    <name>A0A1Q5ULA1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000153">
        <property type="protein sequence ID" value="OKP13239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULA1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012163092" evidence="1">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="74" mass="8326" checksum="27E0FB2375C89993" modified="2017-04-12" version="1">MSQKMKFILSVLCIVVMLFTLRPMALGSVMKPLHCRTSGLYQRFSNLPFNTVLRSFSDCHGSELSGPSFGHFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULQ8</accession>
    <name>A0A1Q5ULQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="7620" checksum="3D4D70890175D5A6" modified="2017-04-12" version="1">MSCFSIGENIEGPVDIPGADCGDSASASSKNGFVERGRSGRELVEPAEGDKARLRKGLLEPKLAAVGDTWSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNC3</accession>
    <name>A0A1Q5UNC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNC3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNC3"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="111" mass="12457" checksum="1F5B98AC52EEE5D0" modified="2017-04-12" version="1">MSPTQYKLMFRVPPSHLEVCKQAVFNAGAGTYPGGMYAECCFEVLGMDQFRPTDKSTPFIGKPGQLERVAEYRVETLCVGEDVMRNSVKALRKAHPYEQIVIEVVQLVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNS1</accession>
    <name>A0A1Q5UNS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nitrogen regulatory protein areA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_225</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNS1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011420">
        <property type="entry name" value="AreA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07573">
        <property type="entry name" value="AreA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="686"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="473"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="595"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="739"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="764"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP14119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="893" mass="95163" checksum="9CA83DFCB20DC5A9" modified="2017-04-12" version="1">MEGMNHGGHGHGHGYGHGYGHGHGGARPSQPSALAFPGIDIDSHMISDDFTFNSAFSPANSTSNNANANPQTQDGMLSDAIFPEWKTGAPRGGDNPDELQKNDPLAAQIWKLYTRTKSQLPNQERMENLTWRMMAMSLKRKEQEKARISQSQKDITSPNSSGIAQLRLSDQTASNPPDNNNDMNMDATPDPMNIDDFIVPFDSPADYASHAAADRHFNATPTASIPIKARKDHPVNDSAAAASFPHPPSDQRKNSEFGYVTRRVRKTSVDERQFFAGLAVPTRKRPADSSPQVPPVSNTMLAQHSELSSTLPDYSLDHPPTAFAMPGNGTLGGRRPQHHHTSSIPFSLDTFGVGEDHGIHSAGPYQQHFTFSPSESPMTSGNPFSNLYAQTPLATSLNSTEFFSPPPSGYQSTVSTPQPIYEGEQSMFFNDVPSTESQAQRRIPTYLQQQRTSNLSASLQPRHMFNTTNGEFSAPTAVTGPPNTMHQSGFSVSPAQHVDPTQVLGSGEFSSTAPTNSMFTFGGDSDNEDDDGTPYERGGITMPNDFPSMDDNDMNGGLTWDSGFAGSVQSLPGFNGPHRKHVTIGSVDMMDGPADWQHAGSLGRGLGSAASVSDVRNREQDPRRQKIARTASTPNAPALLRQSMNGINSNPPTNHPSPNTPPESGLSSAVPSRPGSPGGSKNGDPNAGPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRSSANSLAVGTSRSSKKSSRKNSIQMPSSLVASRTPNGNSSESPPAMTGSSTMGKPGVIPIAAAPPKAGPSAGVASARAGVQVAPRRQRRLEKAPTGSDPDQEDSPRANTSAGRSKVVPLAPAMLPAAANPANHSIAGGQGASQEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP94</accession>
    <name>A0A1Q5UP94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_52</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP94"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="149"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="491" mass="53440" checksum="28CABA9A882FB6FA" modified="2017-04-12" version="1">MGSKTPENERRNGGSEPSSSTNANDTGGEPRGAHLSRDGDGTVGDDGDDDGDDDHEAGVTTVSLTGQPASETTSNKKNKKRKKSKKKSSSLQQSSPPRVPLTDLFPSGQYPVGEIQSYAPVENTARTTSEEIRYNGRTHLENDSFLNDYRKAAEIHRQVRRWTQETARPGKTLMEIADGIDDGVRALLDNDGLAPGAGLVSGMGFPTGLALNNCVAHYTPNPGQKDIILKSSDVMKVDFGVHINGWIVDSAFTMSFDPTYDSLLAAVKDSTNTGIKTAGIDVRISDVSAAIQEVMESYEVEINGKTYPVKPVRNLSGHNIKQYQIHGGKSIPFIKTRDQTKMEEGEIFACETFGSTGRGTTFDGPGVYGYGKDPFAPKKITSHLASARSLYQKINENFGTIVFCRRYLERLGVERYLAGMNNLVSQGVVEMYPPLMDIEGSYSAQFEHFPNSTITAVAPGPAAAAALPVECRPSRQRDRRCRVWCGSPWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPY4</accession>
    <name>A0A1Q5UPY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aorsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPY4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="4">
        <location>
            <begin position="57"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="399" mass="43604" checksum="CFE7F55DF5F4B31D" modified="2017-04-12" version="1">METGQWVCACEQLSAFRRQKRLLHKRDNILIHGASEQMHLPDSDAPGVLASLGCDKLITPDCIRAIYKIPLATKAHPKNSLGMFQEDNYFHAEDLDLFFENQTTNIPLGTRPLEAMIANTEGDGPSSKFGLESALDLQVVYPIVYPQTITIYQTNDHMDAQNSSQGFLDAFLNAIDGVSYVILNLLYRPNLMTMQSYCTDCALGQCGDGKRVNPNSPAEPENRVLCGLYKPANVISISYGGPEQNFPAPYQRRQCNEYVIPTRSYRLPIGLPVATFLMRIPNRYMKLGLQGVSVLLASGDHGVAGQDGCLGPREDIFSPTFPAKSVSTSYTMDLLGSDIRAFSCPYITAVGGTKVLPGHRPSAPETALYNSEGNNILSSGGGFSNVFQAPSYQQAAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ10</accession>
    <name>A0A1Q5UQ10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ10"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ10"/>
    <dbReference type="OrthoDB" id="4360359at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="42"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11483" checksum="111DDF2C1DF97C95" modified="2017-04-12" version="1">MVAVMEQLTDRPGWIVNIFDDQVVADWRKEVVATNSLISEMAWTWCVKELRDKALDFHEKQHIRVLYTGACVCKSDTADLRALSEAFQQSVPSVLEQQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQP0</accession>
    <name>A0A1Q5UQP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="51" mass="5559" checksum="DB584073353CBB8D" modified="2017-04-12" version="1">MLGLALIYTKKTVIINIIEDKNPLAVLGILKPIFDELKDVGLGMPATSYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URH8</accession>
    <name>A0A1Q5URH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URH8"/>
    <dbReference type="OrthoDB" id="544103at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377:SF0">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012660055" evidence="2">
        <location>
            <begin position="21"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="41403" checksum="053C4E0B9EC1EE90" modified="2017-04-12" version="1">MGSKLLFVAILQLQAIFASAMHRPAEWDRHDEIIMAWPSIENDAYAEKGGSRDLAAATRDISAIAEAVAEFEQVTLLVTPDRLDEAKKRFKHDPDDIFVQTVHDYPKLDLWMRDMAPTFVFDGCHLVGVDYNFNGWGNKYPVNASVSLASQICDNMNLTRISTWLVTEGGSLEDDGEGTLLITDSSIINENRNPGKSNQQIEAELQRTLGVAKIIWLPGIKDGDVTDGHVDGLARFIAPGKVVMSRPNTLDDSKFSKVFLDARAILQNATDAHGRRLEVVEMVEADLYSLGLDRRTLKDIESGEEDYPSLSYVNWLLVNGGVIFPQFGDKKADAAALELIRGLYKDRRVKTVRLDQLPFLGGGIHCSTQEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNW6</accession>
    <name>A0A1Q5SNW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNW6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNW6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24346" checksum="56CF97457D45FEE0" modified="2017-04-12" version="1">MENFEEVIRSPEFRFLIEPDRKKLTVHTGVVQNLSPPLAVLMNNGRMKESLSGTAAIEDIEEATFIAFREFGYHGRYKTLSRGDEGNSDDLSADGYAKSIETESIEARRWAQFKSIRFTEKAALPSSNPDFLTHAKVYVFGTRYLIDSLREKALKSLHRDLCEFQFGSQTVSRILDQLEYAFQNTGRQEPDRYYSLRMMVIECRMQGKVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQX8</accession>
    <name>A0A1Q5SQX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQX8"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="612" mass="68286" checksum="7B3A02A0EAF6EB41" modified="2017-04-12" version="1">MAGILDEFLGGLAVQIQNRDGAKLQDFLQIEPPLSDAYQRMIQELRERYPSGPSDSELLQRCEALVPRTKGGSSWTAFPAFMKLYFTFLRDVNTDNLLDTYNQLKGLLNQCVLALGDSQMGVIVLPTVLYLSKVLAKLAMGLDRRPELIAHILRMEGAMDNDESVEKVTLVEQSANVVREAFIKCLTDRTGTPGPQGKPEGKRVGIYLMANLCLKLLFQCGKLRNAEQMFASISAQSPPLAYFPASQRVTYLYYLGRYLFSNNLFYPALIALQAAYDQCHRQAISQRHLILAYLIPCNIIMGRFPSRKLLQRPEASGLTDKFEHLCRLIVRGDYIAFREYFSPSSPAAEWFSRKGILLTLRNRCEIMVWRSFCRKVFIYSGFHGDPQAQAQRGPPPYLYLEKLTIATRWLQSQHGQTQQLNGANHATPKFHFYGSQIIPESTDPDFGGLNGSETPTAQQLLEKYGDYLAPDGFFDGGGHWQDNMPGQLIDGNPGADYDAFELNPYAEATEDGPDADKQSLLMDEVESILASLLTQGLMRGYLTHRNPRFAIPGARQRGALPTGFPNIWETIFAREREDDSVPGWVRPPPPGALGAGGGRVVNLSGARPVGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV46</accession>
    <name>A0A1Q5SV46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SV46"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="256"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO91891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="54677" checksum="055822DF4B6FD874" modified="2017-04-12" version="1">MSYDDRVNARPSLNDESDVEEEALVNDYREQVNFEDGMSDLDRTTSLGGSQAQDLQAQLTAAATPLEYQATLETKFASYDNYCSLFHYILNSEGPVDLEVPSYYWAWDVIDEFIYQFESFCRYRNRVARSGSSEEEAQVLRENPNTWGCYSVLNVLYSLIQRSQINEQLAAIKRGEDPVAFAGEYGSRPLYKMLGYFSIIGLLRVHCLLGDFSLAIKTLDDIEMNKKAMFARVMAAHFTTYYYVGFSYMMMRRYADAIRMFSHILVYVSRTKNFQKGGNNYDAIAKKNDQMYALIAICVALHPTRLDDTIHSAVREKYGEQFHRMQQGGPEALPVFQELFRSACPKFISPTPPDFDNPAVNVDPVDHHTAIFMDEVKNTLFNPTIRSYLKLYTTMDLKKLAGFLEVEPEQLRSWLLVNKQRSRQIRWVEGGLLDGEAVISNDLDYALEDDLIHVSETKAGRRLVDWYLRNLARVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVK5</accession>
    <name>A0A1Q5SVK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVK5"/>
    <dbReference type="OrthoDB" id="4710131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013316263" evidence="1">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="237" mass="26136" checksum="BE874575976C2AD3" modified="2017-04-12" version="1">MRLQLLSFLGIAIFTSLVDATGCSKCLNQNEDKIRLGCFNKCKDAFNPSSTEYQVCRDQCTEFVFQDHCCTSSCSGNADVCLNDYFHRVGLTKRESSNEESFYRSQLDAIRENPDLLDKRALLAGDAPYHLVRSTEDLRSLNHPDFKETIVYDVSEAGSSGTLDRRVDHGKVCCLAAKSVLNVGALAVGPALQKDEWSEEEYAGLVLVGFGVAGAYTCNLVYNVQCVFFNARPAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW76</accession>
    <name>A0A1Q5SW76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="260"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO92271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="764" mass="85354" checksum="2228C07B8ACD09B0" modified="2017-04-12" version="1">MSLPPYSPQVGSQPPDLSTLTATPESGPSEYSVPPASESFSQNPHELYDSSIAPAGEMALEAFIPHRNVQSYSPLNGFPAFFEQVMLPGLDADDATHNTQQPRVFDFMQDTDFTFSDTDIFGTDFIPDLDKALDVPMAFSGFDDPQHPSLDDQESASRRAAAFGRSVWLWVPEKNQHAFSDDKRLPLRDSDSIPYTHQNRLDSIKIPGNLSYQARDDILKLVLRTGGSRLSVTTFPSADYLDTLIKVGIGKRTETDAWIHPYTFYDSVYQQLRPELLTALVAAGCVCCGMPSINKTGIILQEITRVGLAELVEDDNSVLRDLQYLQASMLWLDIGVFCGYTRKMQIAESYLQPLCTVSADLGLYMNHSSSPIYKAVRRGAAFDRSTYTVITPYTFGNDEDSLQRAWHAWVRQESLKRLVYHLFGHDVDVATAMNRPAIISYTELTLPFPSARELWLAPTAAAWRDIWTSKYRMTGCSELNLRDLLSDPSLLSQLPPDLDRAIARTTLLQGLSLQVWEFRQQMLLSQNSRSGPRATTRLWLQSRQEDLYTTLRAVQEDSPNAPPVTILLNDFVMMCLHIDIDAIQRFVGKMGELDARRAYPGLRDWSRTKEARSAVWHAGQVLRAARNVVAHEFRGFDSLAIYHATLVLWVYGLIQCGETKRLQVATPMSEADPTPPVLLDGPEDPVTKSFLGHGVGRPGLMMVQSRGGNEGDVKVFCELSKPRAVMAVARQVFEGNCPLPLPEDIPPPMIQNLCALIDDLGNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXM7</accession>
    <name>A0A1Q5SXM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR repeat-containing protein P27G11.02</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXM7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXM7"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="484" mass="53583" checksum="7E26F2205A14F58E" modified="2017-04-12" version="1">MFRAASRRASAQAQKLAQAQRQPWTRSIYSNNGRPALRPRCNNINSNLFTIPHTRHLTIGQKIRLKYREASKGVFRKNPVLLPLAIFSVIGGIAVFAYVSYVEVTRVQPQYHKFPQPVTDQLRTAVYYTEIDLNPPKALKAYKEALRIAAEMGMHPFSDEVLGIKLQVAMMLEKSGLVNPAVEVLERTKTEALKWIEEGRKAESAPGDAAKAAQVPVKTNTSSEIAQINADDLQDAEKKLKEMQEFEAKQRDRALKKVVGIEMKLAELYASEYIQDEKKAEDAQVAAVELCLKEMHRRQKLGLPVGGGAAGEGDSEAWLNITEIATALAELADTYTAKDRSELALPLYLRALEMIRVTEGDSPSCKQVVLLNSVASAMAGQAQVPAKPRPQEKQTASREQTIDAARQWAQKAIDVAARIQPPVRNEECDMTCVAATYNLGEIAELQNKPDVAQQRYAEAKSLAQGLGYEEGVSMADEALKRLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ14</accession>
    <name>A0A1Q5SZ14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="19051" checksum="5333466E7A89EB9C" modified="2017-04-12" version="1">MQDLLLDQSASASSIAGTTPFPLLSREGVRAYRRALFQQKVLDRCASSPFPGTLVLRDAAKESNFIKDFWTHPQTMSIVSEVMGVPLNVVMPTEIGHTNVQVEGATVSEMTRKLKVEPSVEKVELSAEERAYNPLKDASAIIPWQSVHSRHLANSISKIDVAKAMILILTYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ90</accession>
    <name>A0A1Q5SZ90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12279</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ90"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="543" mass="58985" checksum="82840A1919886CD4" modified="2017-04-12" version="1">MGSPTPSFTGAKPNVAQLETIQDLEVTVTERSQPFWKLILEHRRAFMYALFANSGALLFGYDVLMQGAITALPAFTMYYGSYFGEALILPAMWQGLWSAMNSLGIMIGASSNGFLQDKFGRRPMFFVGGVIAAIAETHLDMRKTGGALEFASPELGSLEARRGALLAAKIILGIGMGILMSTCQTYVSEISSPRLRTILLGIFPLFVIVGQIMSVSVIFGQVMNFTEMAIKIPFGSQWAFSGLAIITAFIVPESPSWLIHKNNLAAAENSLKRLHGSRSDVAGFIQDIQRTIEQERSTSIEFGTVQYSDCFKGSDLRRTRIVALINSLQQFMGVSLIANSTYFFIMAGMSSTKALAINQISLGLSILVTLLGWIVLAKVGRRTAIMSGFVAAAILFLTMGIAGCFHKTTIATNYIGVSLILTGFVGGLSVSTAYPIVAAEVPSVRLRAKTLGIGFFINAFVSWIFNFCVPYIYNVDEGNLGGKTGFVFCGTCIVGLVLSWFEIPETKDVTYVRLNYLFRIGAKTREFGKTNESGNNATAEPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0J6</accession>
    <name>A0A1Q5T0J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0J6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0J6"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="52844" checksum="3BF9BF94B1FF4C41" modified="2017-04-12" version="1">MGARSRSGCLSCRRRKKKCDETKPICAACLRNALSCVWPDTSPLGAAPEVVSTPQLQTQTFPARSVPASDAWALTIGAPRDLPTITIPASPSSFPLLGSAASGSETWRLLDHYLKDTANRLACLQDSENPFLHTILPVALGDELIMNSILALSGVHMMQRLPRLNLEMQSLTWSRYTRALQQLRLALSETIDGSNVDAAWRALLVVLIFYLLEATRGNDPKAMQRHLEGAHYLMAHVLRSGETPTQPSIVSFATELYVYNAALASFTTNSPPALITSPSMSLNSLGSADREIGVLCGCAYELFTFVPQVAALLRSFASCESSETTFKEDLMLEYYSIRAQIENWKPRSDQRELVLCAELYQQSLLLLLDYRFTDKPTDDIVDLAFWKLNSIISQLPPNSPIATTANWPLFAFGIHARKSHHREIIRSYLQSLVKFFGMGVMSTALRQLEELWISEPGHDVISKFFTNQNELLLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0U4</accession>
    <name>A0A1Q5T0U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LMBR1 domain-containing protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0U4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0U4"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="688" mass="76537" checksum="5709242561A96FA7" modified="2017-04-12" version="1">MFSVSVSPVSVGSNIFFAFALCSISALVLLLLRRFLTIRSTPAYLLVPIFLALALPASVVLLVPIDLASSARNGTGPKAIWLPDRMVLVCWRIAYWLIFMLTWAILPLLGEYVDSGYREPKARILYSLRCNARYQLIVLTCAVVGLIYISISIGFDPTSIKGTVMALAYVWGLVLAIYLMGHGLVSIPRNLFRNANVSGRLKRIQAHAPKVHDRLMDAVNELESLNSQVAQLQQRKTGTARDFQEWIEDLSETSGSGSGDVRVPILETPETSGSVPSVITERYLADLTRRLQRARHMKARFVDEWDRVVTLAADLQAIINSSASKKLEFGAGPRRSSCLPKVKFLNPYLRYQLYSNVIPGLRLVFGAIFAVASVCIVWSELIKSLAPQFSAITLTVIPNWKEEKPLGFGSQVIASLWLLYMCSAALVGVSDVKVWGNRALVRRNTYGESACWYASLVARLTVPIAYNFLTFLPKDFRRTTTFYEFLGRLINLTHLGKGFDYIFPIFILLPICATLFNLYGRVKNICGFGLAEDDDLNDVENNPAGYGMGGWREGRDLIERELNGFGSLAVSSRGGRSTWASDRSDDESVGSSRLRVATGEGSRSPRPTQRPVTAPTVVDGEEEEEENFFQSFAHRVRNTFETTNKPQWLQGEPFRLPRWMSGDNNTTEEGGVTRLFGGRAVPGRLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Q3</accession>
    <name>A0A1Q5T2Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho-GTPase-activating protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Q3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Q3"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000044">
        <property type="entry name" value="Rho-gtpase-activating protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000050">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000073">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="2"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="213"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="468"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO94482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="885" mass="98480" checksum="2766BBB396143FD7" modified="2017-04-12" version="1">MPGFSDSFWTPDYATGLGVLYGKLQQGVVENRQILTIASMRADAEEQYGLRMGDIAPSVDRMSAAGFGKDDGASVRKAYEGVRTEMIEASRNHQKIASNIRELVVAPFRRWSDQHDYRVQTSHDNLQARIKEHTKQVDLVKKLRSHYFNKCRVVEDLEEENKLAFQDPDNSPKIKPTPKIVLPTPEEEPEEDPYEIGDRIYPPEEIKRLLLHMLDNIRLGDAKVPIIGTYQNTSSGAEIVEYIQNNMGATNLTQAEAIGQDLVDNGFLRLIGNMGSTFANSSKMNYQWRPKVFQITGIPEKKKPLMRVTSVASSEDGNGGESPITSVQEMLAGWNPLNNPYPNETPSEKLRREAFEADEKYKAAVRRLDQIRCRLEEEVIENLRFMEQCELDRLKAIKAVVLDFSGAISNVIPNLQSTVDHMMLYQETIQPLGDLRYLLENYRTGGFIPRVQAYENYYGSVEEQNFGVDLEARARVDRKRVPILVTTILTYLDNAYPELEGDEARRGIWLHNPPLTQTHQLRNALNNSKVDYREVLPKFEIPIVASVLKLYLLELPDSLVSSQVYEIVKTIYSTTAHETTEEGRIKVLQSTLGQLRLVNIATLDAIMTHFTRLIDLTSAEEQYIATLAQALSPCVLRPRTENSLTMDERHSYRLIRDLFAHKDSIFGELKRQSSALGISTSSRPRAISTDESNRRAAMEARQRAIVNRSRATSPAPGARHRRDRSSGASAATRFPINVTSPQDRSRAAARASLDVPPKTESPTTTEDHPTVNTHVAETAINGTSTESPASAAPSVSSGTTSPPPPPETASEGSPTPTPTPAPTSSEFDKRSSVRSVGARYTRKPGLGSISSFPAGAGAPESDSKRSSLAESEPKGVTLEDKPMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Z6</accession>
    <name>A0A1Q5T2Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Z6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Z6"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="141"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO94594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="227" mass="24980" checksum="1154028D6D8918E2" modified="2017-04-12" version="1">MGFTDFVSDAGLTLANNYLATRSYIVGDAPSQADVVTFKAFSAGPDAAKFPHVARWYKHIASYESEFSTLPGDSSKAFTAYGPESTELPVNPKDKPEEDDEEDLFGSDSEEEDAAVVEERNRRLEEYKAKKAAKGPKPAAKSLVTLEVKPWDDETDLKQMEENVRAIEMDGLVWGASKLVAVGFGIKKLQINLVVEDEKVSTDALQAQIEEDEDHVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5S0</accession>
    <name>A0A1Q5T5S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxygen-dependent choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5S0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5S0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO95571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="608" mass="65484" checksum="B351DB5DA426F35C" modified="2017-04-12" version="1">MSASPSVPAEADYVIVGGGTAGLVLAARLSEDPKTSVVVLEAGKDMTQDPRVNIPALWTSLMGSEVDWQYQTSPQAALGDRCIKEPQGKLLGGSSGINGQAFIAPSKAGIDAWSKLGATSWTWEALQPFYKKSYTLQLPDETTQEHIGLSWLDKDNHGSSGPLKVSFPAVAQDPLSKAWVETFESTGYGLTSDPFSGDSTGGYSIMASVDAETKTRSYAALGYGLPAMQRPDVHIITEALVHKILFKPTSETDDVTATGVETMIQGELHQIIAKREVILSAGALNTPKLLELSGIGNASILRQFNIPVVVDNPNVGENLQDHLMTGISFEVVEGVHTGDPLLRQEPTALQAAMQLYTEHQTGPMASGGVQSGAYMPVRGFDGPQGSQDSMATYMDRFLAQPDNRQNAIREIFAQPKAPTCSNVMFLAQANLHESGKSFVGQDLLPGNFLSLGLIQSMPFSRGHVHISSADPSDKPAIDPRYLSHPLDLDLFSRNLLDLERLHMAEPLARFLKPNGRRNHPDAFLTDLDSAKRYIRDTATTTYHSCGTAAMLPTESGGVVDERLRVYGTTNLRVCDASIFPLIPAANIMSTVYAVAERAADLIKSEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5T6</accession>
    <name>A0A1Q5T5T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transport and Golgi organization protein 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5T6"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35694" checksum="89A29B60B5A23677" modified="2017-04-12" version="1">MCIALISTAHPEYSLIVIDNRDEFLRRPTSSPDWWPEPASHVLGSRDLARATHGTWMGVTKQGKLAVLTNYREDKCAQAVGVHSRGRIVNSWLTSPPSEGQTTHSFVQEMVASPEAKQVGGFSLVCGRVNEPLAIVSNRSSDMDQITWVATEKNQTRGLSNTSVDDRTWPKILDGEKFMKLAIEEHVQAQEDEETLLQRLLGVLSKDTLPRLPEGTSVETYIQHLRKSIFVPVIGAEDDVNQAAEDVAAARVEDEIKQPQVKGPLDQNYSSGPYGTQKQTIILARPDGRLRYFERTLYDNDAKAVPIGQGDRSFEFHVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T683</accession>
    <name>A0A1Q5T683_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T683"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF13">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="27987" checksum="A1E9AEFD92EFBC4D" modified="2017-04-12" version="1">MAYLSSTALPEPFVILTPRLVVIPTPIAVHITSYRALYAELHADAGFCRMGFGERFAVRNWNDDETRDMIETRDIQRSWEKRGLGDFAVGLRLQPKSGGSGADFQQDPFPSVSMLRADELKQFMGPDLTRLEEIQWVGYSGIRDATITSLPPREEGDAPYPDWLEMVEIRYGVSPAFWGKGIAQEASDAIMQWAIREKGVKRFIAETERDNQRSGRLLQKLGFVHSGTNYWKEPLELEWEMIAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6M8</accession>
    <name>A0A1Q5T6M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6M8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6M8"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="128" mass="14069" checksum="6BF4CC3FD78CEF7F" modified="2017-04-12" version="1">MDEAKIETKQSFDAKKHLCYEPPNKIYTMEIGLEGQGISPVAVTAPSHLFTEEAIKQMRAEIFSQPVLDNCLYMSEFVKSTVRGMGSARAHFTCGAWNSDEVLAKVSEVTGIELIPAMDNEIAAVNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8J4</accession>
    <name>A0A1Q5T8J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Beta-glucan synthesis-associated protein KRE6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10732</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8J4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8J4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="13">
        <location>
            <begin position="154"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO96557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="612" mass="68195" checksum="EE08C25A26B05F02" modified="2017-04-12" version="1">MPHIRLNSGRQDPFLETNEGYAPLTGRTLPRPLTPQGPEPHVPVGAQGMSPYGVSHAPESSEFLLPPKLRPTPRDDQGRSGSPDRWSARSAARSSVSSMSRDSRFHFNPFEDYSRAPSRTGSDEYDVNTQTVSEKFNIMPTDGLLLFPEDVEKDDYLHNPDPSDQDRECDVCNRRGVLNVGSLALLTVGILVLFIGYPVMDGDFLCLDVGERPLLSNIRRGLIDPDTPEEAMTKKNADGKEWKLVFSDEFNMPGRTFYDDDDPFFQAVDLWYGVTMDKEWYDPDAVITNEGVMEIRFDNFENHEVAYRSGMVQSWNKLCFKGGRLEASLSLPGDGHIQGFWPGFWAMGNLGRPGHAATTDGMWPYSYHDGCDAGITPNQSSPDGINFLPGMRLPGCACPGSDHPSPGRARSAPEIDVLEGSTAPLNGDGPYIGSASQSLQAAPFDIWYMPDYDYTAVYDPRITQINAYRGGVYQQAMSGLTNLNSRWYNGTEYQIFAFEYTPGAVGNVTWFIGADKTWTLDGRAIGPNGNIGQRMIPLEPMSLVMNLGMADNFAPQNKSIREYMPAYLRFDYIRIYQDPDDVSVTCDPPGFETTGYIDAHRKAYDNHNLTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V6</accession>
    <name>A0A1Q5T8V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qutE</name>
        <name evidence="7" type="ORF">PENSUB_10803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8V6"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="147" mass="15764" checksum="F5274EE7FF9A325C" modified="2017-04-12" version="1">MPGILLINGPNLNLLGTREPHLYGTTTLADVETNAKALATSKGIHLEAFQSNHEGAIIDRIHAARGNFDAVLINAGALTHTSVAIRDALIGASLPFIEIHITNVHTRENFRHVSYLSDKAVACIVGLGVYGYEAGIEYAARYMVKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9G8</accession>
    <name>A0A1Q5T9G8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9G8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9G8"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO96860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="566" mass="61618" checksum="C16A48681872C77A" modified="2017-04-12" version="1">MAGIFEAPRNADTLFLGGQKITGADVREQNVLATQAISNVIKSSFGPSGLDKMMVDDIGDVTVTNDGATILSLLDIEHPAGKILVDLAQQQDKEVGDGTTSVVLIASELLRRGNELMKNRIHPTTIINGYRLALREAVKYMNENVATKVDNLGKDSLINIAKTSMSSKIIGADPDFFANLCVDAMLQVKSTNQRGEVKYPVKAVNLLKAHGRSVTESVLVNGYALNCTVASQAMTTRVTDAKIACLDMNLQKERMKLGVQITVDDPDQLEKIRQREAGIVLERVEMILKSGANVILTTKGIDDMVLKAFVEKGAMAVRRCKKEDLRRIAKATGATLISTLSDLNGDEKFETSYLGHAEEVSQERISDDECILVKGTKVHTSASIILRGPNEYSLDEMERSVHDSLCAIKRTLESGSIVPGGGAVETALHIYLEEFAVTVGSREQLAIGEFAQSLLVIPKTLAVNAAKDSSELVAQLRVRHALSQRVQDGDANEEEKAIAKKKTYRNYGLDLTKGRVHDTLKAGVLEPSMSKIKQLKSAVEACISIMRIDTIIKLDPEQKQDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB00</accession>
    <name>A0A1Q5TB00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB00"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB00"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="135"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO97383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="61542" checksum="28E21C457B0AFE08" modified="2017-04-12" version="1">MRAAFSIPRGFIPTPRLPHCRPRILSSRSFVASRAIRANSTTSTNGNPQKDGSNASSWTASRTLLVSALAAGLGYGYASYGQESPRATKNPQYGSPKDFEKAIAELRAKLGEDTISTDDEDLLQHGYSEWSSLNADRLPVAIAYPTSTEEVAEIAKVCHKYRMPMIPYSGGSSLEANFSAPYGGMTIDFAFMNRILDIHQDDMDVVVQPSIQWMDLNEKIKHTGLFFPVDPGPSAMIGGMVGTNCSGTNAVRYGTMKDSVINLTVVLANGDIIKTRRRPRKTSAGYNLTGLFVGSEGTLGIVTEATLKLVPIPELTRVGVVAFPTVRDCASTAMQLIKKGIQVQCMEIMDEVQMDVINKAGGTGRTWSVSPTLFFKFSGTTAGVADSINLTRQLAKNNNAVEFTFAKDEKEAHDLWSARKQSLWSMMALRKEGSEVWSTDVAVPLSRLPDIIEISKKELDSLGLFASILGHIGDGNFHASIMYDRQDPEERVRVEKVVYDMVDRALEMEGSCTGEHGIGLGKKGSLKKELGPGTIDVMRSLKRSLDPHWLLNPGKIFDLQEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB17</accession>
    <name>A0A1Q5TB17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline/ethanolaminephosphotransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29636" checksum="C596055E34A16CED" modified="2017-04-12" version="1">MTFYVQTWDEFYTQVLTLGVISGPVEGVLTLCLVYAITAYQGGGSFWHQPMLETFGVAKPSFLSDRVYEMPFTQWYLVYGAFVLFFATGSSIWHVMQVRRERGLNPITPLYGLLPMVAIWTLVPAYLYLQPTILENYTIPFGLYVGLVNAYAVGRMIVGHLVQSGFPYHNILLYPLGLGVLDSAGAAVGLWANPVLGHGSNQIMFVFGCLGLAIGIYSSFVFDVITTICDHIDIWCLTIKHPYVEETERKDGAAIEAHVEGAAKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB20</accession>
    <name>A0A1Q5TB20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA adenine N(6)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71840" checksum="358071445F7D88E1" modified="2017-04-12" version="1">MSIPKKVLAQRWMPVDQYPLTKAINSHVLKKLKRRTVLQASIVSEKLCGVYEASLLTRACRAADVLQRVSPYLNKASPIDILDLWPNAGLLSSTIHNYLRPRRHLLVEPDLACYKPWLQRLVDSDPSYKLISEEIYTRRDWAEVFEAHLPEQVSSHQKQIAGQSLPRNDTLLILASPPVPAQKADHYTPQRWWSAMMESCMQQRGVHKYGSVRILASLPPGEVEGILPRTVAERRRPALLTETVASRAFEVAGCYEEEDSWVTIKPLEVTLKGRERVAERASVHQVVVPAGREAPPLKLAPVSLKHDRSEVPHSPRIFTGRHQTLLDDIEAGNQGDPKTPITKSPAKTARQKAQMALHKENAISHSRHELARLEIEVDQASQTLSRAAADPTKTTEELEQLDHHIGARKTALTDQLASLHHRLYKSWDRLVDDYRTMNASNNFDESVLLYDRRPSEPLLIDRFELFPREPRTIVYFEPDANPEFLNKLSHLSKEQRQHIEGLFEALSSVFGPRNHITVGELLKILFLERPSNDIIKAVPTLAPFAIKRLKPGHGAVPLADPTVDSNTVFQENLNYDVSDVRLRCIPSGVMWDILLEYQKHAPDITAIQFSRMIGGTLTSFRAGRNLMVVPKRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBM2</accession>
    <name>A0A1Q5TBM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBM2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBM2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="131"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="664" mass="73012" checksum="6EB917260F0E00A2" modified="2017-04-12" version="1">MVTTAGVPPSLLSSLPWACSTRRIAGTAVGAGVGASVLLSRRGALTTPVHSVQGLAHRPTARRLHTAVWPSYGITTPVPDRQLLGLAQSPFRFDTGYALCAKRPPRPFPPPFLSLPSSSFSDPLTTHSLSQDKRLSVRGELVRGLNNGDDAIIVAENFLGVDDGVGAWATKPHGHAALWSRLLLHFWALEIERRVSSNATTLDPIEYLQTAYEETIRATTTPTQWLGTTTSATALLHWTREHNGTQKPLLYVTNLGDCKILVIRPSEEKVLFRTTEQWHWFDCPMQLGTNSVDTPRKDAVLSKVALQENDIVLALSDGVMDNLWEHEVQTIVQDSLKKWDAGHVQAKDLAPSPELSDDRMVYVARELLNAALNIAQDPFAESPYMEKAVDEGIAIEGVLTKCSLAAITAAQPINPKTGKPFRPYHLPPPTVLPLRHCSHNPESEPIDEIDCLLSLLSPNAEVKKNKEHYILATADPAVKKSDNNNDNQQRKRKRDEEREEEQALRRARNLRVRARSIPGVPIIYVKRSVMVLEPMSTPSENVREGVERDKFRVGLPEPQPKAEDAAESAAKKKIPGLKKAKGPNPLSMKKPKKRTEESGASKAPKKSDATEGSKGNYTADQPDGEDAGAPKNKRRRRHHKSGPREENEDGAPSAEAGQAMEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCE5</accession>
    <name>A0A1Q5TCE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCE5"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="12186" checksum="D454E4ECEAA040FC" modified="2017-04-12" version="1">MAPDNTVNFSGNNNQGFQTRSQPGDNFKEANDKCLNDLRLTNPRDDKERIKNTKGGLLEGSYKWILGHPDFQRWRNDDKSRLLWVEGDPGKGKAMLLIGISPGRAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCY3</accession>
    <name>A0A1Q5TCY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrogen assimilation transcription factor nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCY3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="657" mass="74171" checksum="0A8FC8ABE22D23A9" modified="2017-04-12" version="1">MSKRSFDESRGNQPSEADHNGLLAIHELLSPDEQDHDPTPPAGQTKRPRNFIATVACETCRLKKTRCDESRPKCGLCKSIGLDCVYNERRSSKRDQSLTMIMSTLHRLETKLENIPSSILSDLQALEGQLRHTNGNSQEVHPSPARRDEGRHTSIMPSTATPGFTPAARDGDDFDWEQNQPAPDAPGRISISFSQHGVILWPGARNILPEQLLSAYELLGKNYVIELESTRPPLPMFTSPFPLHSGEHWLEVLPLAMIKGLADAFFAVFNPFTPIMDKTFFFSFTLGAAIESGFGYTMESCLVLNVLALGCLGVLAYQEGNYPLPGTQSHRFEPPEWMNVVYEEQAGLRFFNEARRRIGFLMCNNDIQSCQFFLLSSLYYSHIPRPMDAWAMIHRAATCCLSMLTNHDVNFDEWEGDMKSRVYWNCLMNETILVQELHLPPSGLTRLEEQVPIPKFIAFETTGYPSTRYPSSTVVDDSYFQYHFLAQVAHRIILTRIRHSLYFYSDSGTIPLPAINTELQHQLEQWRNNLPSAIQFTDAQLQPCYSTPAGDMSSVHMSPSSAASPNHVTPRPTDPNRPLSPAVAVTDAMLRGRYMIAKFHIGRPYLYKALRIPNLLTDDDLEQIKSGLQNAMDWPVTQGIFRKMKSCIPIKFAFCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD96</accession>
    <name>A0A1Q5TD96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoplasmic reticulum membrane protein 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD96"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112691" checksum="0507E9EAA1E4351F" modified="2017-04-12" version="1">MSPAAEITGATPGQEVKLNGHGNMENGDADALRKAHEDKQNGSGNLTPSETAASQNSAATHDQTTDAGEDNLNGDGLEEQITNRGHTNGQHLASHSQGLGIIVQLSPDDADKNGRAAVLEGSKVKAALAELAEDASRRPSDDKEKILKLSPDKIQELTSSPESIPYRTATPETNGGQRVVSDHFHSNGTLRPEIRESILQSLSETPPLEDSLKARNAKSSAMEEASLPASPALPRPSLNGSVRNRPYTSRTFSTPGLSRHSILPTNNERLAQTWASRSKQDRNAPDRDLKTHLAASPQIIETPIPSPLPVSIPIPPVSIPTYLQLELASGRPSPLYIHRPATNDFPYESSSAKIERLMNFLILPGALEQVLCFGSLACLDSWLYSFTILPLRFIKAVYILSESWAKNLNAEFWFIWKFVVNGVGRVWRRRNHDSERHESEPDVTPRLPNGSSTTQDATTSLDRDPRLREPEPSKRRHRASESRRHHRRKKSMPSALLPDDKADILTGLLMVATCWALMYFDASRMYHWIRGQAAIKLYVIYNVLEVLDRLLAAIGQDVLECLFSREALERRPDGRSKILRPFGLFLAALVYTVAHATSLFSQVMTLNVAVNSYSNALMTLLLSNQFVEIKSTVFRKFEKENLFQLTCADVVERFQLWLMLTIIASRNIVETGAFNFIGDLGLGSGFSSQASTSTNSTPLSTPPRSASSILPQSFTFFPSSILSSVSSVNSFLPTLGQVLGPFLVVLGSEMLVDWLKHAYINKFNNYRPALYGRYLDVLAKDYYTNAFGDQNLTRRLGLPVIPLSCLFIRVSVQTYQMFLASLLPQHPSSTALRSTSLSSIHNHYAPAPLPSTPPLTMSNVIPVSVAHVSAFFSALMDNAMPSPAQSVQIFTVILLLTAYIVLLILKLLLGMSLLAFARSRYKKMKGLESESRKASSSHPPTTENTVRKDEFNVEGSRRAGGWGMVEVGDEKRRWIYGDDPEGLRRVKEKEDKDKNKDKDLKIDHVQRYEMVAKKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE14</accession>
    <name>A0A1Q5TE14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Conidial yellow pigment biosynthesis polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TE14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000116">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF40">
        <property type="entry name" value="NORSOLORINIC ACID SYNTHASE STCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="369"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1281"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1648"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1757"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1281"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1440"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1613"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1839"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1613"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1638"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1846"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2148" mass="234102" checksum="7790F0DE0FA13506" modified="2017-04-12" version="1">MARVQQIILFGDQTDDFTSLRRLLSPNVEPLLNDFLNKAVRGVRTEISSLPLQVRQQYPHFASVASLLDWRDGQKKAHPSIDSALTCINQLAHFIQAQSSASTYTSPSDIIIGGLCLGSLSAAAVSSCQSISELPNVGAETIKIAFRTGLHVSRVGRAIDQSETESWSMVVATRSPDDISHRIDRFIEAQHLPSHTRPYISAYLSHAVTISGPPTSLFSLRQSAEFASLAPRSIPIFAPYHSSTLFNPADSASILGNLLADEKKTTSNIPFISSTSGRPFEGTDIRSRFEYALAQILLETLRWQSFVNGMIAALPDHEGPDAFKFHVQSFGSTAGPRLAEAIEAATSLTRYQPDPSSNLSLKPTDNIDSSKIAIIGYSGRYPHAECNEEFWDLLIKGLDVHEVVPASHWDARTHVAEPGKGKKNTSATPYGCWLQNPAAFDARFFNLSPREAPQVDPAQRIALMTAYEAMERAGLVPNTTPSTAKDRVGVWYGVTSNDWMETNTAQNIDTYFIPGGNRAFIPGRLNYCFKFTGPSYAVDTACSSSLAAIHLACNALWRGEVDTAIAGGTNILTNPDFTAGLDRGHFLSRTGNCKTFDDEADGYCRGEGVGTVILKRLDDALADRDPICGIILSAGTNHSADAESITRPHSGAQQHLIQSLLRTAGVSPYSVSYAEMHGTGTQAGDAGEMNSVLSTLAPSSVPYRTPDQPLYLGSAKANIGHGEAASGVSSLIKVLLMMEHNAIAPHCGIKTRINRKFPTDLGDRNVHIALTPTAWEKQQGEPRRVLVNNFSAAGGNTALLLEDAPSLPETTEAEDPRTHHLVAVSAKCASSLEANVKSLLGFIESAGEDISLPQLSYTTTARRMHHLHRVIVQGSSIPEIKSQLEAALSRGDGANRPIGIPKLVFAFTGQGSQFVGMSRKLYESMPSFRSNMQLLDRIAQSQGFDSFLPFIEDESESSLKRFSPMTAQLASVCLQIALARLWASFGIVPSAVVGHSLGEYAALNVAGVLSDADTVFLVGKRAQLLEEHCTLHTHSMLVARASVANVESTVASMQYEIACINAPEETVLAGPNDQIEALQQTLSQGGVRSKTIPVSYAYHSSQVQPILDDLVQAAQPIVFNKPAIPVLSPLLGDIVESEGIFGPEYLQRHCRETVNFHQAMQVARAAGVINDRTQFVEVGPHGVVSGLIKAASKTSQAHAVPTLQRGRDDWQSLGEAVSTLYRAGLDIAWNEYHRSFTAAQHVIRLPAYNWNLKDYWVQYVNDWSLRKGDPPLIQTARLEESTTIHRIVEETKDGIVVEADLCRKDLSPIVQGHNVDGIPLCTPSVYADIALSVGEYLRSRHQCHDVDTVVAITEMTIKKALIAKPSGTHLLRAATTVDWDAGSALCRFLSMDSKGQPTNEHAHCTILLSSPSRRAAAETERIKIQRRVREMREGIEPGKTQRFNRAMVYKMIRPLAEFHQDYRTIEEVIIDSTTLEAAARVCFSEVQAPGKFHTHPSYLDGLAQSSGFVMNCNDDADLDREVFVNHGWKSLQVYEPLRPDAHYSTFVQMVEGESRMYEGDMIVMDGDTVVATFQGVVSQGVPRHVLRYVLSMESGDPALVASAKKALVASAKQTPKTAAPAPKRVEQRATPAKPTAMPPVAAKSPSPASSSSLVASALQIISDESGVSLSELEDSCVFADMGLDSLLSLVITSRFREELPIDVPVEGFFITYPTVADLKTYLGQHQSEDTALTPTPVSEVPKPVEEFSLPIPQTKVASTSANWTTALSIISEESGISIDELTDDCVFSDMGIDSLLSLVIVSRFAEELEMDVPLESIFTDYPTIGEIKVLFLADQASSDDSSSADENNVTPASRAITPSSETSEYFPPGDDKEMKPAALPVPRTTSVLLQGSPSKTDKTLFLFPDGAGSATSYTGIPRVDSSVSVVGLNSPYHRQPHLFNCTVNDLIKSYIEEVRRRQPTGPYHFGGWSAGGILAYRATQMMIEDYQERVASLTLIDSPVPHGLDRLPQHFYDYCNKVHLFGASQGDKAPAQAPEWLVPHFNATIDTLHEYYASPLSLTDANKPRVSMIWACSSVMDNADIPRPPSCEEDTEGMKFLTEARTDFSDNGWARLFPGCEIRIERAHGANHFTMMRGDFAPKLASFIYQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE53</accession>
    <name>A0A1Q5TE53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE53"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13899" checksum="7337CDB1AB03CD4B" modified="2017-04-12" version="1">MSRLGCAWELWEGRGTEVQDRTQTDYRRIYLRLEKYTSKPFGLTVPMRPWMSIMNRRRIWNACVELLEYYSEGRTPGDNPRSRGLPAWMETWELNLPDKTSDVATFLGTFYRHRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEA7</accession>
    <name>A0A1Q5TEA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEA7"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000286">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF87">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012321370" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="334"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="45274" checksum="1F4721E070249B56" modified="2017-04-12" version="1">MEHKSQLSLLLHIVAILPFVQVVLGGTALGQTPQMGWNSWNAFKATVNYTVVQEVIDLFESLGLKKAGYNYVLLDDGWSSFNRTTDGYLQANATSFPQGIEALAKELHGQGLKLGLYGDSGHYTCAWRPGSWGYEERDAQTFASWGVDYLKYDNCGGFQSMTEAPQIRFGAMKNALALSGRDIFYSVCEWGYQFPWHWGGGIGHSYRMSGDITTSFTNETSCQCKTAYCLNTGYAGCSVLTIINKMKEISQYQTRGHWLDMDMLEIGNANFTLNQQQTHFAFWAALKSPLIIGADLSKLSNDSVAVLTNQAIIALNQDVLGEPVIYREEFSKEGLFQVWTGKVQGGFVILLLNEKSYPQTVSLVLSDLGLGSPKKVVELWSDEKLTNCTKFDGILESYQTLVFKVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFX7</accession>
    <name>A0A1Q5TFX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFX7"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012276406" description="Cyclin-D1-binding protein 1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="41908" checksum="02EAB6FDCB0EFCA9" modified="2017-04-12" version="1">MATQFPVVISTTLTLLEKFQATLASPTTATAQAPSKDANASAEADTTTNALPLLSNSAAVLKSQVTKLSLLAITAPFTHSAVSTVLRACNESVLPSLVTAALLVTPAGYTQAFHTEILLLVKTALVEFSTLVRDVKGIAETKDLAKRERDAKKEKEGEISKIEKDAVMVAVGRVWDACDAVTEVAGKGVVGFVMRRVEQWRDLVKDAVEELEDWDPEEDDEFFDELMGEEKGDDNDDDDEDEDEEEDTAALQENKKSTLRFIKPIAQVYPAILTNRLKNAGDKPLSSTAGIAKLESLMINLQSIPDQVDEAAGALYENNWSKAAEYLKKTQKNAAQAVNSVSSPWIVSEIAEGEQQPADKFATWSKMWLKVMDEVSKPIDAAVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFY8</accession>
    <name>A0A1Q5TFY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFY8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31180" checksum="1419B4FF5880AA7F" modified="2017-04-12" version="1">MQPLIKTKQSSHLMYTILAVGMLHLNRASPSKERSIAESYFWQHALQHYQKALSSKLSKDNVDAILSSCMLMSVMTVCPENFQPTDSWVLTNKPEAMNWLCLQSGLRCILTLASPYIPSSIWATAFAGIDKEGDEIFDSPQQGREGLDPDLADLCGIDDFTTENINIYYSPLRILTPLLTLERDASNSGHCTSFMGRLECDFVNLLRERDPPALIILAHWMGLMCCLSQWQPWIEGRIRGECTAICMFLEHSTDPRILRLLQFPAEACGYKLHTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG77</accession>
    <name>A0A1Q5TG77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein AFG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG77"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001493">
        <property type="entry name" value="Mitochondrial ATPase (Afg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="574" mass="63672" checksum="74BDCFB892C23488" modified="2017-04-12" version="1">MQMRRPPAKLCSDCVPCAVRRSYGARVAPMPRSITENSRGMRPMAYSTLTRLPNRTGLSSNVPTQQTAVPVNSVLLQKRGLATTAEGAASAPAAAEAFETKPSGAPQDGPMREYDVRVEEGRLRDDPYQRGIIQNLQDLFEALKHYNAPSVVHPSIESLDPQPKKSFFGSLFGSGTTKPATTTAPEGLPKGLYMYGDVGCGKTMLMDLFFDTLPPNIKTKTRIHFHNFMQDVHKRMHVVKMKFGNDFDALPLVAADIAETASVLCFDEFQCTDVADAMILRRLLQFLQSHGVVLVTTSNRHPDDLYKNGIQRESFIPCITLLKTALNVINLNSPTDYRKIPRPPAAVYHHPLGEDADQHARKWFDFLGDPINDPPHAATQVVWGRKIQVPQASGKAALFTFDQLIGTATGAADYLELVRHYDAFIVTNVPGMNLNQRDLARRFITFIDAVYESRAKLVLTTEVPLTNLFLSASDVRSSLQGKGEGEGDDHSDLSDAMRNLMDDLGMSVQALKNTSIFSGDEERFAFARALSRLSEMGSREWVERGLGVGKSVVEGQQEREAWLKTRSHWSEDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG96</accession>
    <name>A0A1Q5TG96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_8645</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG96"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="201"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO99258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="529" mass="58586" checksum="8741073E54F2E760" modified="2017-04-12" version="1">MTSVSRYMSYRGYQFPMLKYWSPSLGVTMLGVVGAILFLAMTLGPKPYYWPTDASYGSSPPIATRAGWMALALLPFVLGLSVKANMISVLTSIPHEKLQIFHHWTSYAMFLLALIHTFPFIIYHIDKGDMVKQWKTSLVYWTGIGAIIPQAYLTIMSLPFIRNRFYEFFKATHMIAAVVFIVFFFLHCDFRLSSWDYFIASGIIYFLCLSFSQVRTYLMHGIHTATLELLPSGLARVSVPTVIKWTPGQHVFVRFLTPDLHLLTAHPFTISSVYRDPDQAGKAPELAFYIKPRRGVTARLAALAAKQTGITKKILIEGPYGGVSTHHMSQFDTILVIAGGSGGGFSLAMVDEALRVSGLHTGEDESGQESRRRLQVVFSTRDTPMADWYIDEIESRLSQSTTLPGSDNGFETSVSVHITSKPDLTRSTSTLDSEKGTAGKLPPTDITTTGSFSLNIYRNARPDIPGLVARTVAMAHANPMPNGKKQRIGVLVCGPASMLHDTRNAAALAQKRTFGGEIEELYLHSESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGN1</accession>
    <name>A0A1Q5TGN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nephrocystin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000660">
        <property type="protein sequence ID" value="OKO99396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TGN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="365"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="575"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="699" mass="77661" checksum="1EC4E1562D9263AF" modified="2017-04-12" version="1">MNDEEVEQQARDVLKWLAIEGNSRWLIIFDNIDQYSPFSGPISDAYDIAEFFPGADHGSILITSRLQGLTELGKSFPIHTLDLKHAVQLLLQSSRLLLKNTAKELQSDPDTIALACRLDGLPLAIVIAGAFMRETGTSIPEYLEFYKASWTDLQLQSNPERQYQQGNMLQTWMISYREIQRRDANAAVLLLFLACFDNRDIWFELIRTSRYSSNLPNWLEKTTSSGIEFKIGVKALIGFSLLEAKEQEGGYAMHPVVQDWCIHLASTDKTVNPIQLNELAVVSVGYIVPSASTRNYSELQQRLLPHANYVRHKGCSDTNIAVSGAFHGLGDLYSNQGKLQEAEEMYQQALAGKEKALGSDHXSTLNTVNNLGSLYSDQGKLEEAEEMYQRALAGYEKVLGPDNSSTLDIVDNIGSLYSDQGKLKEAEEMYQRALVGKEKALGSDHTSTLNTVNNLGLLYSDQGKSKEAEELYQRALVGYEKALGPDHSSTLDIVNNIGNLYSGQGKLKEAAEMYRRALAGYEKAFGPDHASTLNTVNNLGSLYSGQGKLKKAEEMYQRALVGKEKALGPDHSSTLDTVNNLGNLYKYQGKLKEAEEMYQRALAGYKKALGPYHMFTLNTVNNLGLLYSDQGKLKEAEELYQRALVGYEKALGPDHTSTLNTVNNLGSLYSDQGKLKEAEEMYQRALAGYEKALGPHDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGX8</accession>
    <name>A0A1Q5TGX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutaryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="7">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="238"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO99496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="398" mass="43929" checksum="745FF4DEA24B0086" modified="2017-04-12" version="1">MSSSVSTVPFADPLWLNRYYSPYYNDSHRRLQKEVREYVDTYITPFCEEWEKQGFVPPEVQRRHAELGYTAVASFPLAADYLNGQRLPGDVNPQEWNGFHDLVVIDELARCGYLGIIWALGCGNSIGGPPVINFGNAEQKQRFLPDMLSGKVRFCLGVTEPDAGSDVAGITTTAERKGDVYIVNGAKKWITNGIFADYCTAAVRTGGEGTQGISALIIPMKAPGVTCKKIDNSGVHASDFNHERLWLACTSLRMARVCAEDSYKHAISRETFGKKLIENQVIRSKFSAMARSLDSTYAWMEQLVYISEEAKRNGTDAGMGGLFANLKVLAGQTLEKVNREAQQVMGGLGYSKNGRGARIEQISRDVRVMVVGGGSEEILSELAVNQETKVMKKLQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH46</accession>
    <name>A0A1Q5TH46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nonribosomal peptide synthetase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH46"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11551" checksum="481846D34F17865E" modified="2017-04-12" version="1">MPFHGWGYFTSRYNNPEGQEAFHSPATPEIVLNYSGLYQQLERKGALQQQTDELDGAISDIIKSARRFGLIEVSVGVRKGCVEFDISYNRHMERQEDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIJ2</accession>
    <name>A0A1Q5TIJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2,4-dichlorophenol 6-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIJ2"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="603" mass="67197" checksum="87DCD1921F76806F" modified="2017-04-12" version="1">MSPSLLYNDTFDEDVPILIIGGGPSGLLLAFMLEKFGIRSLIAERYATRLAAPKAHALSPRSLEMCRQFGLDVNEIRMTGTSRKDAYWVNFITSLAGESVGKLPYERMDAEVLNSTPTMIHNIPQPAFEEMIASRLSQSNLVEIRKNHTFISLEQFDGYVITTIKDRDSNETYRVRSKHVVACDGAKSAVRNFLGIESEGEDSYETMMTIHFNADLRPIVKEQVGMLHWAMDPLVSGFIIAYDLSGNQVLICNFDSKKYPVDSWNEEHCRKVVDAAIGAKTKYDVLSFRPWILSRKVAKSYRDGRVFLAGDAAHSFPPTGGLGLNSGLGDVHNLAYKLAAVHRGSATEALLDTYEAERRQVALVNSQQSVKNGKKIFRLLKTLGTTDPDVDIARQNLYQKIHDEKAIVNINKGIEDQREHFDNLGLHIGYVYGDNRIPENASVYEPVCVPGARLPHAWIKLSDPEKLQLPAIDSSYFGASPQKVAEMTYSTLDLCRFDSFTILVDESFFSEFKPAIQKALQQVADITASSLSLQVVVMGLDFVLQHGQEKWDDVVPVKQGKAVLVRPDQHILAVLDRKDSAAFIVEALKSHLAWSTSNRVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIK6</accession>
    <name>A0A1Q5TIK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIK6"/>
    <dbReference type="OrthoDB" id="4366014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8503" checksum="61F230D01222BEB9" modified="2017-04-12" version="1">MSSFTSSKSSSKTMSSDAASTHSTVSTATTLKGTDFPNKKKWFSLSSKSEPKHVNKSDAFYAKQAIHNEAVASYFSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJT2</accession>
    <name>A0A1Q5TJT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJT2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJT2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="248" mass="26996" checksum="C0C3AB2A2D37B281" modified="2017-04-12" version="1">MAKPTIVFAPGAWYPPTVFDGITKKLNEHGYNCHTIAFPSIQQATTVQDLRPDIAAVRAIVEPEVNAGREVIIVSHSWSGLPVASALDGLERSDLENAGKKGGVIKLVYLAAFIPQVGESLISAFGGTPPPWYVLDEQNGTVTASDPFALFFHDVPNGQEWAQTLRPHAWSTKNSPATSAAYMKIPSLYLLCVDDFAIPLAVQQLMVDRAQRKGASIETEKINAGHSPWLVRPDEVVAHIRKQAGEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKP3</accession>
    <name>A0A1Q5TKP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bypass of stop codon protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_7729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKP3"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="447" mass="48198" checksum="E0F635560E50C465" modified="2017-04-12" version="1">MAAVQIVPDSTLSVSPSDERHPTPIPEDQGSEDDTPPLHAVNVALRWNGSKTMIWRVLATFWCAFVMGSNDAAYGSIIPYLELSYHKNYTVISLVFLSPFLGYTVSAILSNLIHQRLGRRGVAFIGPACHLLAFAVISTNPPFPVLVIMYIFVGLGSGIQNAGWNVWISSLANSHEVLGCFHGFYGVGATVSPLVATTLITQVGWEWNTFYYLLTGAAALELINATAAFWTETGSKYQQDHPSAPGREGVNQTRLSLTYRVTWICAIFLFLYGGCEVAIGGWIVVFMTSVRHGSPFASGMAETGFWLGVTVGRFVLGFVSPRIGEKLSIIVYIVLAIALELIFWLVPDFIVSAVAVALVGFFLGTIFPGVVVVATRMLPKHLHVAAIGFAAAFSMGGGAVFPFMIGAIAQAKGVSVLQPILLAMLAVALMIWATLLRAPSQQSQHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL62</accession>
    <name>A0A1Q5TL62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body associated protein SnaD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL62"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL62"/>
    <dbReference type="OrthoDB" id="3911405at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="573"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="866" mass="97557" checksum="2996339556B5D8FD" modified="2017-04-12" version="1">MANTGYTSPFPTSHDTIGQSTLVTPLFMPSSPPQQPSSPATEAPQSPQSPRSPQSPRSPQSPPRPESPASEHFDPHHDDDDGDDEAHVSNEGSHHEDQLQDLSRPSTPGSPSSFDLDARLADYTLDFSAFPSSKFLDGKDGPPLPDPENEEDKLSDVGGPEDFTANMERYLMGEGMSSVRKSRVSERSELPGSASQYNSTRPQQPAVEEDVESGEISEFGPPVDMSTPSHLLHRTSALARDSTQLEDIEEDPNDELSAMASPSERKMSMNSDDEAENLEQRLQQRIAELEDEVQNRDEQLHKNRKRVLEAVSAVEQIRHLQAELQIKNEQLDEITARSGDEAKLREQIEALQRQNDQREKLLQQSTVSQPDLGAVEQQLRDMQKQLQSRDSQSSLDAERLETISHLRQQLHLTQEQLKKRDETLDETMTKLKEVTRAKEVQLHEKNTEIDRLKGEIDDHALENERLETELERVNRDYETLEDRLTALEIKSAPLEERNHSLEADLTRAQSQVEAQESALKAVAADLPIGSRSTYSEILDLIKDLGGEEPSPRPGSPPKEKSFEESDMQIGQEISRLQQELQEATAAQKAADAEAGRLREQLSETQNLIKTIEKENSRLTTRVEELTSDLNNTQHELTRTQEEHAECLETIARLEEEAIDEPPSPPPSPPQTRGADHVEVREAAKTAELEATHQAQIRSLQTVHSTAISTLRSSHAESMRKIRNSLTTAEQREAEIRTELTTIRASIATQESQLRKTFKSEIRRLEAVIAAKDETAAAVDERIALSVDRREREWERRVDLLLKERDRMAKALMMYWGEKELGKGPGPLAEGKERHRRDGDDADVKQGQAYKYKYAQKHRSRTGEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TNJ2</accession>
    <name>A0A1Q5TNJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000633">
        <property type="protein sequence ID" value="OKP01799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TNJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9695" checksum="379E818D9E52B062" modified="2017-04-12" version="1">MRGIMSFEVITTREAAPTPRNPARMRFSSQVAGQMTPKAFEVSKATCTPRNAAFELSALKLPWYAVVAVTRVSLVATDEACEFFKIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ05</accession>
    <name>A0A1Q5TQ05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ05"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP02315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="695" mass="76535" checksum="D5230C90F88640B5" modified="2017-04-12" version="1">MAKGQTGANPSEIEPTLPAMLSTPWTFLHPTDQLHAQIADSAKQILDPLAASVVDGQTLRRQINKKRKRVDAELDGVPPLQLKNLYVAGFTSNQIWEQATRILESAGREVERDITLLTRNDDNLSSADEDELDVSDPEGSASESDDGDSLSDDFSEKAILDDNDEELLEESQHSDEEVSESEDIMDDAMSVDDSEEKDPGTYVEDRFGLNDGFFSIDDFNKQTEHWERLDARGAGNDADDSDDDEIDWHANPMAGMGTISNPSDSRKTRGSDDKDGMDDDDSEEDGPTFGNADLNGDSDSDDDAFDGEDAGMGGIENANDIRYADFFAPPPRKASSKKARALPKTQPSAEVMEGDVERAMADVRRDLFDEESEGEAEVDEMHEAGDSNVPRSTHEKQRARIADEIRRLEAANVAKKEWMLTGEARAVERPVNSLIEEDLDFERVGKPVPVVTNETTEDIEELVKRRILAKEFDEVIRRRPGAADVESSRRGRFELADTKPQQSLAEMYEADHLKATDANYVDPKNQKLMREHAEVTDLWKEISSKLDLLCNLNYKPQTPQISINVVSDAPTIMMEDARPTAGSAVGGPSALAPQEIYAPGDDGRVAGEVVLKTGAVISKDEMSREEKARKRRQKKSQRKEDVSTKPSGKAAEKQQLVSDLKKGGVKVINKEGKVTDMSGSKVGATTKSSGDTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQJ8</accession>
    <name>A0A1Q5TQJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQJ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="11504" checksum="9B9DF3569FB5EDEB" modified="2017-04-12" version="1">MLEVGDLDRHVLECDSNFKAIGKRVTYWTVGPRIPYSLKIELQGGQSPREGPECLEGWMAWICHHFHDKNAHCEGVLVIVCDLGSAAQRPQINCAVSSLLAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUC3</accession>
    <name>A0A1Q5TUC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="9" type="ORF">PENSUB_6836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUC3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUC3"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP03827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="258" mass="28367" checksum="39428BDE3639148F" modified="2017-04-12" version="1">MAPITDDVVSGLKDTIGKLEARVIELEGRLTGSKPKSVTEQIRVILMGPPGAGKGTQAPNIKDKFCACHLATGDMLRSQVAKKTELGKEAKKIMDQGGLVSDEIMVNMIKSELDNNAECKNGFILDGFPRTVAQAERLDDMLSSRKLPLQHAIELQIDDALLVARITGRLVHPASGRSYHKIFNPPKKDMVDDVTGEPLIQRSDDNAETLSKRLVTYHAQTSPVCEYYKKTGIWRGIDASQEPGQVWKSLLGVFNKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U057</accession>
    <name>A0A1Q5U057_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U057"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U057"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12821" checksum="EF55394DC3628449" modified="2017-04-12" version="1">MPVPAIGTPVGLEIPVKDTKRGMENFVGAPEEYLLVFKVDGEMFPGGGVIKKVPEGELGVGGATKVFLYVDNIENAIEKIEANGGETTSEKEAEGDRAFYQYFQDTEGNTHAVYTYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U064</accession>
    <name>A0A1Q5U064_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U064"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U064"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012976717" evidence="4">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP05857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="304" mass="31237" checksum="122338D9075E62B1" modified="2017-04-12" version="1">MQFNTIAALLASLSVVGSVNAVNIISSNDDGWAEVNIRALFDTLTAGGHSVVVAAPAENQSGTGSSQKTPTTLTEACEFNSCPSGSPAVGYNASQPRLNYINSYPATSMKYGINSIGPRFFNGAPNLAVAGPNVGNNIGLAVLLSGTVGATTYAAYNAGIPAVAFSGATGSQTAWNASATYPDYSQIYADLALNLTDHLVTSGAPYLSNNIWLNVNFGAVSSECSKAEDFSFVLSRIHVAIPLITADDVTTCGSSRLPSEIAVSLKSGCYASVSVGVADTKGDANATMQEVVLKKLSTLLTCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0H9</accession>
    <name>A0A1Q5U0H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0H9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7379" checksum="611EC362FEBA0ABA" modified="2017-04-12" version="1">MQESVGSRADAGPIGAIGGYQVLVFTGGYWLSIPETPLLNMRASRRQQDSSQFRLYGMASQKLVCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1C8</accession>
    <name>A0A1Q5U1C8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1C8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1C8"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="118"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP06292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="68502" checksum="F55537C41B1041C8" modified="2017-04-12" version="1">MDSSNLAEHVLWPDFPIAESQPEHLNWDSLVDHGALQPDWWTCNGTDTSEIDNEVCSNANSISADELGRNFISQWSDSSVKNDHSIQSSVQSSLASSSREQLAKDLSKNPSSTERSTRAKSYPRLSLDAVKALRLWLHQHQNFPYPTPDERAQLEQQTGLNKIQVLNWFANARRRRRKRMEHDSTAGESLGAGTSLSPLERWKQSPPESEPAATSDIMRALENMHHYPDQGQAYYSDSGRLSVNSSGSSGSSFLFGAPSMSIFENSCSSGSDLAITPIHRQAQRPPTPNPSMGKRHQRRKNSRLAGQLEKPKIQGSRMFQCTFCCDSFRTKYEWTRHEKAIHISVDLWRCAPEGGIIEADGFNICVFCQAQNADGNHLETHNFLQCQDKPSTLREFSRKDHLRQHLRLMHNVQDHHFLDKWRVSLLNLHSRCGFCNSTFTTWDERADHLAEHFKTGADMSQWTGNWGFDPDIELQVRNAMPAWLLGQERTTVDPMKMSDATQPHDQLPSMHNFPKGVDLYMILRNGLVSYIQDQISTGLYPSDEMIQSTARLMMYGSDDPWNQTFAENSTWLAALKHDVHFGSSKTLPGLHTTSKESSIWPKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1M5</accession>
    <name>A0A1Q5U1M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1M5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1M5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF2">
        <property type="entry name" value="SODIUM-HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="57"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP06388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="464" mass="50281" checksum="76D8258EDB6D5943" modified="2017-04-12" version="1">MAGFLAYHEPGTEWISTKIIRAGIIGQIAVGIIYGKPLANILEYSWQQTFLAIGILAAATGVCFPIGLSYLLLYLGFGYVETFIIGAALSATSLGTTFSVISSAASAIDLSQTRVGSVLVSAAVIDDVVGLVLSSVIGDLRELSGPDAGHVNLGWIIGRPIVASAAMAILTPVFTKWIFAPIFRRWIEHKFAKFDHVSNILLMVLVLSAFISIAAYAGTSVLFGAFLAGTFLTYLPSKHPDGPFVVMSREEGERNADKSPKFIHTFELYLLDTQKYLMEPLFFASIGFAIPFVELWTGERIWRGIVFTLLMAFAKVRNPQPQYLSRHRIDSNISLQFVVGLWIPGWKFLGSSKGRSGAALDSPTIKNDETGYGPASLAGLLLGSAMVARGEIGLLIIEVGYNETSYVSQDGFITAVWAILLNTIIGPVIVGNLVKYRGKRIGEGEWGLQTQEQPLIPNPSRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1P5</accession>
    <name>A0A1Q5U1P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1P5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1P5"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP06354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="53033" checksum="72DB1A7823FA66C1" modified="2017-04-12" version="1">MAILTRFKSYIRGQETVPGEAKLLRKIDAFILSFCCLCYFANYLDRSNLNNAYVSGMKEELKFKGNQLNLINTVFTVGYIIGQVPSNLALTYLRPHIFFPAMMLIWGGLTMVTAAVHTPQSIMAIRFFLGLAESSTFVGTHYILGSWYTEKELGKRSGIFTASGLAGTMFGGFIQTGIQKSLNGAHGLAGWRWLFIIDGLITIPIAIYGFLLFPDTPTTTKAPYLTSEERAMAIARIPESGSVKVPLNLTFAKRIFTSWHWYGFVILWIIAGETESFSSNALLALYMKSSPTHHYTVSQLNDYPTGVPAVGIVSTLFWATLTDFMGGKRYLVGYFIAITGIVTSAMILTRFEDTAVVFGAYYWAGAVYACQATFFAWCNDAMRYQDDRFRSVVIASMNMGSNAVNAWWILLFYSANFAPRFTKGMWAMIGCSIALAIWTTGIILMTVREEKKREGQELRLGDADVKRIEETTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4E7</accession>
    <name>A0A1Q5U4E7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Copia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4E7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4E7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="9363" checksum="CD615522E14FC06E" modified="2017-04-12" version="1">MNQGTNATIICGDNQGAIALSSNPQFHSRTKHMEIQRKWQGEVQDNGTVKLKYIPTTEQIADGFTKPLARERFGWFRKGLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4L1</accession>
    <name>A0A1Q5U4L1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4L1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4L1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="135"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="558" mass="61107" checksum="42809428BD6BDA06" modified="2017-04-12" version="1">MGAGDTPEDVAISPMSLQQQPGEASFVNQSQDTLSLEDCSSLLWPDSEGLLQNILAIDPGIWNQPASLMPQTLSIPPTPLQVTSDGRGIAPSNRSSIAEDGERAIQSLSGLINETADALWQLAHTAVATSWHTMILQKRPYDSCNGVCLVQTMLLSQIYAALSKSRTLRTTSQVFHGLALFWASHCGMYEGLEQPPLPSPDAHPEVILQAWHRWIAQETRLRTLLGLYIVDGVVSQFSGNPTFARHMANPLTLPSDESIFNAATAEDWIQASLNCRLLPSNNSRFCDVFHTLFSKDNRTTMSMSPQSSVSLFQHKIVLEGIRSLVADATRTKPAPVGVPSKKDIGNAVLRLREQIMQNQHLSLPDQAVAMLQWHTICLDLVVSTARGTRRMCSLHGIPQRIFGGDSRDEQGIDPRRWAQSKNARIALLHASQLQELATHLPLGMAYDINVPGAVFAAATTYSAFALAGAGKVVLPSTIDWVAVVKAATMDEQVDNSGPHTIPNETLSFVNDGISARGPLRDLSYELTSIRSFFRSLSLQWSVAEEMEEVVGAWIERMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7B9</accession>
    <name>A0A1Q5U7B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 52A12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_5695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7B9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7B9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP08328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="514" mass="58546" checksum="B84FA77F7149E9F4" modified="2017-04-12" version="1">MLLSPAIALFAALYATFLVLRYLVQLHHHRKLSKQLHCQPPAAGNSGWLGIPGFLRLSKAVREKRWIDYMCDQFDIHGPTFTQRFLSRKLLTTIEPENVKAILATQFQDFCLGTRHEQFYPLLGDGIFTLDGAGWTHARGLLRPQFTRDQVADLSMLDDHITHLINLIPKDRTSFDIQRLFFLLTLDSATHFLFGESVGCMSPTTTGVLEKSAVRNAQGFADAFTTAQDYLAARSRAQGLYWVINPKEFREANRRVHEVVDHYVNVALEAKRNPEKKHGGDGRYIFLEALAAETDDPKMLRDNMLNILLAGRDTTASLLSSTFFYLARYPAVFKRLRKEIVDAFGDKNAGVEITQTKLKDIPYLRYVLNEVLRLQPPVPANFRVATKDTSLPVGGGPDRRSPVYVRKGTMVAYNVFAMHRRTDLWGKDARTFRPERWEENAKHGWEYLPFNGGPRICLGQQYALTEASYTVVRLMQHFDCLENADPDTRLEPIKNSNLTMMHDHGVPVKLYASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7X5</accession>
    <name>A0A1Q5U7X5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7X5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="169" mass="18611" checksum="3701F26506C609B3" modified="2017-04-12" version="1">MPQEMFGGIYISNDALLDLSPHQIFKPARALESMKFGQPLKRNTAQKSGRMLHETAIEEPASLEEHPQAGIGEIDQESAFNPPKGTPVSSIDHGTQPVLSTTSPHRGGDRGQDVKEGVTFDQRLRSQDAIINKDFDTSSPNRMTQGSPADTLGKLKFRPYPREVVKVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9Z3</accession>
    <name>A0A1Q5U9Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase cytochrome B subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_5377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome b560 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9Z3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9Z3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000008">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP09291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="163" mass="17523" checksum="8972073A8D612C14" modified="2017-04-12" version="1">MQSMMRASPAAVALGQTMQKRPVTSNAEDPAQILVKQRLNRPVSPHLTIYRPQIGWIGSSLHRISGVALSGSLYLWATAYLASPALGWHLESASMVAAMGALPLAAKVFLKATLALPFTYHSFNGLRHLMWDLGRGLSNNVIIKSGWTVVGLSVTSALALAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAR7</accession>
    <name>A0A1Q5UAR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000493">
        <property type="protein sequence ID" value="OKP09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAR7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="12852" checksum="C7EACFD0C1F5225D" modified="2017-04-12" version="1" fragment="single">APSPSASLTTEFEYILRHHSSLAASIVGLLDLYLCLWKCYVVDSALKIRLEEEQCHLQRSIEWLTAECDVLRQCCNDQALELFGRRQAVAALNDGIVEVLKASEKRAFSVIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAU4</accession>
    <name>A0A1Q5UAU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="4">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAU4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAU4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="46"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="216" mass="23159" checksum="D7F76B0AC7DE553C" modified="2017-04-12" version="1">MAAPRLFRPASRVLSSRLTSASLRPAFAQSALRARGYATEDGVKQVTVRDALNEALAEELEGNQKTFILGEEVAQYNGAYKVTRGLLDRFGPKRVIDTPITEAGFTGLAVGAALAGLHPICEFMTFNFAMQSIDQIINSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVSPWSSEDAKGLLKAAIRDPNPVVVLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB01</accession>
    <name>A0A1Q5UB01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="1">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="22511" checksum="BFBF511B731D1ECB" modified="2017-04-12" version="1">MSTRVQSSQDASSDAQNVSIKVKNRRKRYLDLHPEYFTADLELADPLLYDRLIRRFQTPQEREAQGRAKGFSGVLQTDLMRSEAKMEALAHPDPNAMLSYTRGPSGEILAEDRDDIPASKEEGEKAWQWEMGLRFMRGDDPDFDYTTVDENDEYDDWTEQQDKYFEEEEPEWVVGDARGEDAQAKLQGETGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB50</accession>
    <name>A0A1Q5UB50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB50"/>
    <dbReference type="OrthoDB" id="4369595at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12071" checksum="B729566EA606681E" modified="2017-04-12" version="1">MHSYKLPLTNSLESTMATQVHRHGIQAITEYEYKYTDDEYLYLALNPIEPLYSATPTPTNHASTGAPITNANWWVCCHCDSMNNPDLAPDRCSVCSHYKCAGCNTVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBZ6</accession>
    <name>A0A1Q5UBZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000412">
        <property type="protein sequence ID" value="OKP10002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBZ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="12943" checksum="FCF7AEE777F10228" modified="2017-04-12" version="1">MGSSRSHSLHHASGRDETTIDHNAAYERIVGRVRDDPLLTEMAPSEADYEKLASYMTSMSFLGFIPEHRERCKGEEFTRLYRIVSVAFAQARSKFVDYLLDDYSNGLQYADGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDD5</accession>
    <name>A0A1Q5UDD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein argonaute 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000319">
        <property type="protein sequence ID" value="OKP10472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDD5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="628"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="991" mass="108381" checksum="F9EB7B70E7CC5D1B" modified="2017-04-12" version="1">MSLNRGRGRDSEWQARDDRGAGRGRGRGESRGYFRGDSRGRGGFQGRGGDRGRGNFRGRDDPNDRGRGNLRGGYQGPRIYNDGQLIPTPDPNVKKVEDLTAKALLGRKKTADSVRSPDQPGYGTLGKSVMLYANYLSFISVGKPVFRYSVSIAKDKGRDVPAKKARQIVRLLIEEHFANNRDNIATELNLMKFIVRYKNENETDFVDDPTVLTVTVGATGTLNPADLLNYLTSSNLEGPLMQQEQTVTAMNMIIGHCPKTKKSVVSIDGNRNFSLDASMGEKATLGGGLEALRGLEARRGLEALRGFFVSVRAATARVLLNVQVKYLACYQEGPLPMVIGEYQRANSRSLYRLESFLRHMRVRTIHIARKTSNGRARPAPVKSITGLASPAEGRSGDNQTRVPRYGAGPFEVQFFMGSKGTQGAPAVSAAALTEGKAKRGKKAPKAGPVTPGQYISVGGYFKRDMLRFAVMGRTPALNAESIATKGVRMLGLGEPPSATLSAFGIRVETNLITVQGRILPPPKILYAKQKEVLTMSGSWNLKAVQLSRPGAMKTWTYLYVLVQGARPHWNNPVEMMESLRKFTSVLRSMGIDAAPPNEGQRIVLVGRNDTERTERSVRELHDRYRPSLILGVLYAKDTDLYNSMKQVCDVRCGARNVNFLTEKLQVAQDQYCANVGLKTNLKLGGGNQTLHKSELGLLANGKTMLVGLDVTHPSPGSARNAPSVAAIVASVNSALAQWPAEIRIQPSKQEMVADLDTLLQSRLKHWAQHNRNEHPDDIVVYRDGVSEGQYDLVIGEELPLLKRACETIYPASATSRGLPRIAIIVVGKCHNTRFYPTAEADADRSANPMPGTVVDRGISESRHWDFFLQAHSALQGTARPAHYVTVWDEIFSTGQPAATGALGAADVLQNLTHKMCYLFGRATKAVSVCPPANYADLVCTRARCYMSDLFDPIASATPEASVVGTKSGRCQVPNSHLAVVHPNVKDTMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDX7</accession>
    <name>A0A1Q5UDX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDX7"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="38702" checksum="C13FC5AFEDBF2229" modified="2017-04-12" version="1">MPQKLKVAVAQARTCPSLSATLSSLERVTRNAAAQGVSLLLFPEAYLGGYPRTCDFGTAVGARAPHGREQFLRYFQDAVDLGDTPTGAGDDWVERKLPVAKGSDRRGDGTREFLERVSRETGVFIATGVIEKAGGTLYCSALYVDPNSGVLGKRRKVMPTASERLIWGQGSPSSLKAVTTVLNGVKLTIAAAICWENFMPLLRQSLYSQNVNIYLAPTADSRDTWLPLMRTIGGEGRTFVLSANQCVRYRELPPWITDHAEKEGTALEGDQYISRGGSSIVGPLGEVLAGPIWETCVDDVLESSKSGEFSGEDGLLIQEIDVEDCERGKLDMDVAGSYSRSEFKLTVEGLDLNPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDY2</accession>
    <name>A0A1Q5UDY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDY2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDY2"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33033" checksum="281941BFD54A67D8" modified="2017-04-12" version="1">MLRSDFAKIDSSRTWREHMLEELETWRSQVERLSHRATRGYLSDRWVGMAYNYTIALLHQPTKENVCNGFGDRSIQASTQLALTFRAFQKDRQTAQLWPGLLSQFTVGVTILYCFWATPPGYRTPAYRAAEVSEALRACSTALAILSERWTQAEPLRDVFDILAKEIPTHENPDMSSSSKPITSDSVALIKSHMHVIQEISRNRVVLRMLQEIMTDDFPSSPQDYLQQTDSPRGNHLCSEHCAMFHGTTFFDSMMNLSSDSHNVTGGELNDTYAAFDDSIIFPALFGSAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE34</accession>
    <name>A0A1Q5UE34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE34"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="10882" checksum="3DD614C293D39A4C" modified="2017-04-12" version="1">MIGIQHPVQTHPRFFSCPFPLLNRYLAPLHCSRGPCTRVSWGLSYTYTQLYDEVRTETEDGAKVHTPPAPSGSLDATIYFCDGSPYEEGLQLGFNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEB9</accession>
    <name>A0A1Q5UEB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="9">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEB9"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005725">
        <property type="entry name" value="PRK07539.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="29071" checksum="15C4D6E5C3FCABEA" modified="2017-04-12" version="1">MASKLLPRVSRLLRPISTPQYRSFSAAPQRLSDSLMVHRNKPNNNPTLPFKFSEQNLKVVDEILKRYPPQYKKAAVMPLLDLGQRQHGFTSISVMNEVARMLEMPPMRVYEVATFYTMYNREPVGKYFVQICTTTPCQLGGCGSDAIVKAINEHLGITPGHTTEDGLFTYIEVECLGACVNAPMVQINDDYYEDLTPESIKTLLTALKESATTGAQAPTPGPLSGRSTCENSAGLTNLREVPEWSPEQLMRKDGALDGEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEH2</accession>
    <name>A0A1Q5UEH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="90" mass="9697" checksum="2B1050556D0DEFFA" modified="2017-04-12" version="1">MVTAYNREVQDKVTQINSVPSSLPSDVEADVCNSWATYSENQKHLRSVLIYKHALLGVAGLSDPVLQLVRADQSANDAGNFSGAAYLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF32</accession>
    <name>A0A1Q5UF32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000307">
        <property type="protein sequence ID" value="OKP11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF32"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="99" mass="11028" checksum="DC117C543A550061" modified="2017-04-12" version="1">MLEQDGMTEDRKRLTLAVLQGLAGRCRVVDSERSQSRKLRTGADEWAVHTSALWGTLATVVVLMSSIGLMGVKPCQAFPLSDVIRPAMKYRRDDCTLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG70</accession>
    <name>A0A1Q5UG70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_2939</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG70"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="19">
        <location>
            <begin position="232"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="18">
        <location>
            <begin position="691"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP11453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="924" mass="103478" checksum="7EF032582865B907" modified="2017-04-12" version="1">MGKLDNEGVPEAVPLTRQRSASAASNASSDSGLSVASAAFLDAYKHEFAAGEDGDGDGEGQRYRDLEDGKESGVDEPFLPSKKTKSSSGRRWCLFGVLVCVVMASGWIVAFVFFLVQGRSNAAAISSPSAVEVHEPDSATGGTSYGKPVTLEQVLTGYWSPQSHAIAWTAGSNGEDGLLIEQGEHGGGYLRIEDIRNRKAGGAKVSDAKVLMKESHFWVGTTFVMASKIWVSPNHEKVLVLSDYASNWRHSYYGNYWIFDVATQTAEALDPDNHTGRIQLAWWSPESDAVVFVWENNVYLRDLSSSKAIPVTTDGGKEVFNGVPDWVYEEEVLSGNGATWWSLDGKFLAMLRTNETDVPEYPVQYFLHRPSGTQPEAGLENYPEVRQIKYPKAGTPNPIVNLRFYDVEKHELFSIEMPEDFEDDDRIIIEVVWAPEQKVLIRETNRESDVVKIFLVDAKARTAKLVRSTDIAALDGGWVEPSQSTWIIPADPSSGRPEAGYIDTVIHEGYDHLAYFSPLDSSEPVMLTSGKWEVVQAPTSVDLKNNLVYFVATKEGPTQRHVYQVKLDGSDLRALTDTSKPGYYGVSFSDGAGYALLSYKGPAVPWQAVVSTQDSVMKKEIVIEENKQLAEKVEDFALPAEVYSTVTIDGYELQVVERRPPHFNPKKKYPVLFHLYGGPGSQTVDRKFLVDFQSYVASSLGYIVVTVDGRGTGFIGREARCIVRDNLGYYEARDQIETGKIWAQKPYVDESRLAIWGWSFGGFMTLKVLEQDAGETFQYGMAVAPVTDWRFYDSIYTERYMHRPQNNPEGYDNSTISDVAAMGENTRFLIMHGVADDNVHYQNTLTLLDKLNLQNIDNWDMVMYPDSDHSIFFHNAHRVVYERLSSWLINAFNGEWHRIAHPKPVESSWKRAKRFVTRRLSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGC6</accession>
    <name>A0A1Q5UGC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGC6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="8898" checksum="7A0F5439B5463572" modified="2017-04-12" version="1">MQASMHPLKEEFISTSTQQTYNIYTIGRHPARTSWQSAPQPTNNPSSSARTNPTNLQVGLATQVSAGQWGWHRQEGISED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGV0</accession>
    <name>A0A1Q5UGV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UGV0"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2670:FF:000004">
        <property type="entry name" value="Ubiquitin-protein ligase E3 component (UBR1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="8">
        <location>
            <begin position="84"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="472"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2152" mass="242150" checksum="9DA5914BF501DF26" modified="2017-04-12" version="1">MHMLAECERILGEGLLRLPSQHNYRYGPKAERDLLELLFRSLVGHNDELVAHLFPDGTPTGSWKLADAQGAREGAEYSEAARGKRCGHIFRAGEATYRCVTCAADDTCVLCSRCFDSSDHTGHQYQISLSSGNCGCCDCGDDEAWRLPLFCAIHTDSGNIKGKERAERELPPDLVATIRLTISRVLDYFCDVISCSPENLRLAKTMEGIKQDEEASRLRPGWYGEGDQEEEEPEFALMLWNDEKHTIRDVAHQVTRACRERDSFGVARAHETNDIGRSVIKYSKDLQRLLAVSKIIEEIKVTVSVRSARDTFREQMCGAIVEWLADIAGCSILDDNEIFRQIICEELLSPWRKGSGAYNADIGMKGIDDHQETENQLPGRTVLLTLPPHGQIVLATTDEDEDEEGDDGNEQDEDEDYVEAHDDADDEDDDMDMELARLQAEADGDDDEEMDMGNEEEIALAERILAGLASTQHMAPRPAPQPTEEQAAQEDETDVVASNEGESQPSASDSYVSIPKTPSGVIRPPPARTEGHWQVRPPIPAVGEKVAPYEDLWQRTRLDWLVLFDLRLWKKTRTDLRDLYISTVVNVPQFKRIMGLRLSALYTALAQLYLIADREPDHSIVNLSLQLLTTPSITEEIVLRGNFLTKVMAILYTFLTTRQVGEPQAVNPNATLAFDAGSVTNRRLYHFFLDLRYLLQSEYVQHRVRTEEQYLPQFLDLVKLSQGICPNVRAVGEHVEYETDAWISASILMREINRLCRQFCESFRNPEIDNGQNLLRAIKTTTMTAIMHSAGVERKRFDQAEIKEEVKFKTLPPFDFEMGSSGQVPCHRVVEFAVEKGSISFHHAIHYTLSWLIECGRGVSSEVMRGVLFEAAQNARVELHAAKVAGNKQIDDNLLTLSPEDLLLTMFDYPLRVCAWLAQMKAAMWVRNGLSLRHQASQYRGVSSRDFAYYRDIFLLQTAMVTCDPSRVLASIAHRFGMVDWMSRNYMPRNGFEDTQIVDVAEEFVHLLVILLTDRTSLTAIDDSSHLTKENISRDIAHVLCFKPLSFSDLSTRLSDKLLDSDMFQDVLEEVANFRPPEGLSDSGTFELKSEFFDLVDPYSAHYTKNQRDEAENIYKEWMAKKTGKKASDIVYEPKLRPISSGVFSDLPRFTGTMLFAQLVHQCLEYVVSFKECTSAIPPTRVETFLQVILHLVLAAVLEDNSEDGSMETEQSQSFNLHAMSKSREIKAGNLTIVGLLERISVTNEFSACGPKIRHILKRLWQKRPRTYTSATASLRFPFDRIETSSPAIDIDNEKELKKKQALERQARVMAQFQQQQQQFLNTQGDIDWGEEDFSDSEPEAPTAHEAKVWKYPSGTCIFCQDETSDSKLYGTFALIQDSTILRQTDIRDPDRIREALRTPTSLDRSADDIRPFGVSGENRTTIRRLDSSGGEVISEKVGLSKGFSPKSTLRGPVTTGCGHIMHYSCFDVYYTGTQRRHSQQIARHHPENITLKEFVCPLCKALGNAFLPITWKGKEESYPGALNTVLPFDEFMTTGLKSALNQSQNFPVLMIEKDKAYQQPYSDLFVDYLSKTLTPPLSSRVGQLMTSSLPSTGASHPLSSVPRLAMPGLFPTTAEDLPPTSPLQQVSTPSDSPMTELLQIYKRLKKTIKMNHISSIFNNSPDTMVSDELVHTDSLIRSFGFSISSVEIAQRGVESEPGSTLLDKIPPLTLTHLRILAETALTYAAVGCVHSSNSPKSRPTHEFQEMHRQKLCQLLVGHPCLSGTPLLNDVRNIEPLLAMDTFVFLAECSLSLLPVLRIDVRHLVQMCYVAEIVKVAVTFILWPLGLKEELAHQGDNDLAGSDVSADRHDVTKHFFDSIVAELKANSVGRAEGSSFPAESGYVKDGEESATPSVILALRRLVSSYALTFLRKAVILLHVQHGVDFPNTGFADLGASELDRLTKTLHLPTLDEIFMSVSPARKSNSPFDAVISGWIFHWNASRSGIRFEDHRLWPSLPHPAIFELVGLPKYFDSLIEEANRRRCPNSKKELSDPSICLFCGDIFCSQAVCCMHNKLGGCNQHLQKCGKNIGLFINIRKCTVLYLHNHNGSWHYAPYLDRHGEVDPGLRRNRQLILNQKRYDRLLRDVWLSHSIPATISRKLESEMNNGGWETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHC6</accession>
    <name>A0A1Q5UHC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000263">
        <property type="protein sequence ID" value="OKP11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHC6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="266" mass="30525" checksum="AA3667947135E8F8" modified="2017-04-12" version="1">MVRGTRGPMQWMLDLRSYGLKIHYNTSTPGYVTWMGQDELLYKDLYFTIGEFRGFIYGLVGETRRILRRYLLLATGSVKIPLACAPELLSLRHRNTDTAFRNVFIEDGIVALATKYYKGFYASNDAKIIYRFLPREVGELLVWYLWLHGTTINVSVYRNIAIGISRRFLRESSVFPQNQFDNSTGDTIADDIDDEASMDPDYFQGYIADLQAGYSSYVAGITYGREVTERAGTTAQRREFFRLSSTDWYRFLGFPDVESGLGRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHE8</accession>
    <name>A0A1Q5UHE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000269">
        <property type="protein sequence ID" value="OKP11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHE8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="7045" checksum="9CB555EFA2C1D6B9" modified="2017-04-12" version="1" fragment="single">PWVPKYHTVALGSDDIRKHAALLLAVDVEVEMGNVGDSVLIRHHPVKDSWLYLNAREVERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI47</accession>
    <name>A0A1Q5UI47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI47"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="632" mass="70845" checksum="7A44C9062A72EF72" modified="2017-04-12" version="1">MVGTQKMHTQGKTRSKTGCRTCRIRKVKCDEEKHPVEGQEPQCRRCTAARIKCEWKGGPIPRKTSSPASSSTLRINPEKPSPRDAGRSDKAGRKRLPPQQSVNSCQAPLLPLHRIGNGDRNQVLQAANSLTLSAFDRDCLSYLQNSTLVIVLGKHWPWSTISYAYHRIAVNEPMVMSMMLASTAREVHRSRLYDQEALSISSLNSGSGANNESCELDGRMHYGRALSSLRQALRSGVKSPQKIEAIFITLWLMIDYENRFGSGAAAINIHIRGIESLLHNHVVPFLRGRAQQHYEHSGPLQKSSPALTFHNGTSSVRPPADLISPATGEQAAEASSGPLISQPDSAEGLGCTSVPLFLLWTLYFFTPAALFFGPTTGRLDSDIFHFFLGNDTDETIPLTLAELYRISRQSPSRFWGETYPMSARLDDMENLPALTLYHRSHVMQFKITEQFKRGAPTETTVDEVSPYQKIINEINVIALEYDTVLTTVRSSQSCDIGEVRRVLETSHWAAITFYSTIVLFHLCFQDIINKHPGTQVHTKLIPLSSAVSLVLELSLKLHRSRPHLIVRITWPLFLAGIATSDRIYQDWVSIRLKELGRFGQNYTRIGRRFDEIIQGGHPYVSEKDFHFLANAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI54</accession>
    <name>A0A1Q5UI54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF4">
        <property type="entry name" value="PITSLRE SERINE_THREONINE-PROTEIN KINASE CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1559"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1676"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1853" mass="204505" checksum="AEA4D4113F67FAE4" modified="2017-04-12" version="1">MEVLAPVACHTCVDKIAEEIAYRPARWEHAVEKLIDDVWAVLVQGRTGFDTTCKDKRAEKLGLLCPALPWYIEPPPSYDDAVNDLPPEYPALPPLAERKTALSPAAPPTPATKSRSQSRSLFKDQSLDVYVDFESTVGVREHKKKKGGGAGAAKKPTAPPPPADTGGSSNDAPDDQASGDANSGGDAGGGDGGGDDSGNGGGGGGDGGGDDWNTWGTVASTKKKTKKQEEEEEEERKAAEASAAAKNTLSWADDAEDGGGDDWDGFTTAGKKKKGKDEAPPGAFQDISLDSGAPQLDLNFETGPKTGGTGFSFGGWGKDWSTGGAPAASKWGLGAIGESPPKEEPKDNNPWGAAKKKSTKTTAGGFDFGDLGSPPAEETKADDDWSTWGVATKDKKKKSLLNPEPAAEPDPEAQPEPAPAPVELEPLPELDLEPEPEVPGSILTEAWYIGLSKKEQRKAKKDWEKKVKDAEDELAKVRESNAAKQTAYDEAVKAREEAEAPPAPDPPAPKPEPEADNDWGWAVPSKKDKKKKKIDLLADPEPVPAPAPDPPPEDDWAGSWGTAGKKDKKSQKEPELVIEEPAPEPPKAKEPEETWGAWGVATKDKKKKKGKEPEPIPEPEPEPEPVPEPEPEPEPEPEPEPAPVHDDPLYDNWHNLSSKDRKKREKKLVQKGRLPIPGKDFELPSNKPAEPEPEPEPPAPEPEPEPEPEPEPIPEPEPEPEPPKPEDDAWGGVWGTTKDKKKKKKGIEEPPPPAPTPPAQGLTPEPEILDNADDIWADLGAKSKSTKKTKAIESIKEEKPAAKGFWASLTGGSAAKTKSTKEKSKSKEEPLAEEEDLLIDVGDDPPNEPEPQPEPEPEPEIVPEPVKEEPPPEKSSKKSTAKLSVAERIKALEQNKKEKLKEAKASSKSKTKEPEPEPEPQPEPEVEPIPEPEPEPEPQPEPEPEPAPVHDDPLYDGWHTLSSKDRKRREKKLIQKGLPIPGKDFELPSDKPPEPELEPQPEPEPEAGKHISRDSVPGSFPDEPEIEVPAEPEPEPEPIPEPAPVHDDPLYENWHDLSSKDRKKREKKLIQKGLPIPGKDFELPSEKPAEPQPAPKPEAEPVPEAEPEDAGAPPTPPPDVEELPKSSKKERPRVDRAASGTGWGFWGAAPPPKKSIKKESKESKEIKEVKETKAVEEAESPKKRDKESKSAEEVESPKKREKEERKESTRDRERERERDRDRSPVAAVRSKSTKSRPKESDAEVEKSSSDREKRREREREREREARSSKQQRATTLSNFVFGQPPPRSKSSRKPESSSKRPSSKPVSRRPSIDPEDEAAMPSPPPDETLEVTDKAAKLMGINASKSKRDRPRAERRKSTPRDPYAIDDDDMVLVDMEVADGQSPKEGSRGSKRKSKRESRTKPEEDDAVMVDADLARGGPDLLSGPDDMAFVDAPPRERRLKRPPPSTPKKQDTGGFMGIFGSLRKPARPEMPDRRKSRSYRDEEARHMTEPERDDRRVRRDRDRDDRRRRSVKPDTDVEGFTTDAAGAAAGGETEPEDAEARRAARRAKRTSRQAPSETREAEVREAEAREAEERRARRKEKIREREAREQRAREEEEQRREEERRVRRAAREERKAREEQAAREAAAAEEAKALERRERRRQREEEMAAKVKRRRSRADDPPVDGYGYAPDDQPDGRRGSRTTDDKARRRRSKAMPAAEQTRAPLMTGGLNHGNTGGPKKDKISTWVYSQAEEPPEPPPIMPTVIDMPPDAATAAENAHSLSSDEEARRAARRRARQRAKYGDMPDGEVVDDVRSRRRESRREGVKSSSGSGDYERERGMRSQHGSRHGGAPAPPSSGAKKSSWFKKLTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UID2</accession>
    <name>A0A1Q5UID2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UID2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72328" checksum="BAC4AEABF0033479" modified="2017-04-12" version="1">MRAKGYTIMEFAMYIALFFNQYVNPIVLENIHWRYYIFYCCFLAVEVVVIWYFYVETWYIPLEGITTLFYGDDFAAATNMEMEKACESGKGFKSAVHIEGRNRKKKCDECRTQCLNCAKLNLECVWQYEGIIRRQAEARSPSTSDSVRSSCSPAEIALDEKQHIQRHDSDHSLTQLSMVVSDNERPGALPFDVELSETDSGNLPQNWMLVPPTESLHGLSLQIDLPPSPANHKRSRPLFQFLISRFIPQLIRPTADGQMRDELNRRSLALAFEHPFCMHALLACCGAEIPSNDPEYHELARYHYTHAVTGLRKILDDGALKDQWVVTMLGIMMLCIYERTKQKPSPGVAIHIAGAAQLMRLHSQTNEDSVEYSGVGQVMYRLVHESFIFHVTTSLPFQGELRPDDHALSTTSAYQYEIESALSMAEEALSDHFHEDIFSQPTSPVLGFPPQLFRCIYTVYRLYQSSNFDQVSMQLCQRLENDLCRWDKRLEASSAELSSPDSSAQPSNEELNSTSTRPSTQALHESTLIGPKLYILGCRILLRRMKGLDLVSVEMGVEDLTHQGMSMIQRLQPKKDYYADYYCWPFLAIGMNLRSSTDREMLLAKALAFCKATNNPTMRRLIDMLPVYWQSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIE6</accession>
    <name>A0A1Q5UIE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metal tolerance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIE6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIE6"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="228"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="9">
        <location>
            <begin position="442"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="58185" checksum="1C44D0695F77B7A1" modified="2017-04-12" version="1">MSSQHFLPLSSPPESPRLLPRRPSLDPEREILSTRGQRILSLLPSRLSSSALQDLEQHASEPPTFLRRGSQLIGHSNARYEWQRYYRPPDSLKGLRKPIRQYYERNNELISQYLYIDRLLDSSLPHNLIEDYSDCHHHLDAHASNGHHPSTDADDTAKITAQANSRATRIKRTPHNLYHIPDEAAPLLSPTAEVEEEHCSHHNIPDPDSHQGVSPEAEERLVNIAIRINFVANVILLISKVAIMVLTSSMSVLAGLVDGVLDFLSTVIIWVTTSLIRRQDRRRFPISRRRLEPLSVLVFSVIMVTSFFQVGLSSINKLMGDDHTLVELSIPSIALMAGTVVIKLLCWIWCRLIPSPSVQVLAQDAMTDVVFNTFSIIFPLIGSFARLWYLDPLGGLLLSIYIMWNWGQTAGEYIRRLTGAAASATDHSILLYMTMRFSRVIQKIQDLKAYYAGDKLNVEVDLVVDERTSLRDSHDVGESLQYILESVPTVDRAFVHLDYDPWNLPSHMNQLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ43</accession>
    <name>A0A1Q5UJ43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ43"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ43"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="39935" checksum="DE15725A9E7D4F19" modified="2017-04-12" version="1">MTFPRLPCELLTLDVMDVSGEMQVGVAHGVNKVRLAPAAEGGRVIDVQALDLHSPADAAAHLAPDYCGECYGADAPPNAIKAGCCSTCDEVREAYANKQWAFGIGDNVEQCTREGYGEKLLAQRREGCRIEGVLRVNKVVGNFHIAPGRSYTTGNMHAHDMDNYFMRDAPSPEQHTMTHEIHELRFGPQLPAELADRWQWTDHHHTNPLDDTKQVTEEPAFNFMYFIKVVSTSYLPLGWDPTFSSAIHSAYDKAPLGAHGLAYGSQGSIEAHQYSVTSHKRPLVGGDDAAEGHKERMHASGGIPGVFFNYDISPMKVINRETRPKTFTGFLTGVCAIIGGTLTVAAALDRGLYEGGMRIKKLHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ53</accession>
    <name>A0A1Q5UJ53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate permease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ53"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ53"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="582"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="840" mass="91620" checksum="C7ABDBBC2DD02C6F" modified="2017-04-12" version="1">MAGGERATKLGHALAKGLGIKVAYRDPLGPATDPVTRGESTFSVGTVDTYSYTEPEPTSIEWIREITPTGQQVLNYLISLFPFLRWISRYNVQWLIGDLVAGITVGAVVVPQGMAYAKLADLPVQFGLYSSFMGVLIYWFFATSKDITIGPVAVMSTLTGTIVLDVADKLPHVPGHEVASCLAVILGGIVCLLGLLRLGFIVDFIPLPAISAFMTGSAINICAGQVTTLLGQTKTVNTRGPTYLTIINTLKALPSSTLGAAMGVTACAMLYMIRAGCTYAAKKQPHRAKTWFFISTLRTVFVILFYTMISAAVNIHRRDKPAFKLLGKVPRGFQNAAVPKMDTEVIKAFLNQLPAAVIVLLIEHIAISKSFGRVNNYTIDPSQEFVAIGVTNLLGPFLGAYPATGSFSRTAIKSKAGVRTPLAGVITAVVVLLAIYALPALFFYIPNASLAGVIIHAVGDLVTPPNTVYQFWRVAPLDVIIFFVGVFVTIFTSIENGIYCTICVSLAVLLFRMAKARGQFLGKVKVHSVVGDHLLDGDGKYGSFGASRAVSGDEDPTHRSIFLPVNHADGSNPDIEIEQPHPGIFIYRFSEGFNYPNANHYTDYLVQTIFKHTRRTNSNAYRNRGDRPWNDPGPRPGKKDADEDDQRPLLQAVILDFSSVNNVDVTSIQNLIDVRNQLDLYASPRSVQWHFAHINNRWTKRGLAAAGFGYPTPTSSEGFHRWKPIFSVAEIEGSSSAAAHAEMVNNKREHNLHHVKDVEAGLKDHSATTETETHGIETASEDSQPVHDDKLSRDLTSSHAYNQRRKVAIVQGMNRPFFHIDLTSALQSAVANSSNEIPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ65</accession>
    <name>A0A1Q5UJ65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GID complex catalytic subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_1890</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ65"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="14">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="15">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="360"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="46713" checksum="10E9379A2D0F8AD4" modified="2017-04-12" version="1">MDLVQKEHDRLLKKLRTSQGINNVQATIDMLQSARDTIAADPNQAAIALTRLQNPVKASFNAINDSLKETHGGLNKYTKSLDKLFKDRPLPSTEHDVLSEQEHLINRAIAMHLLREGQFSVAATFLSEIAEKKDLMHNPASPSSSASPESSSSLLNLDEVPSPEIRKEFASMYYILSQLKERKNLLPAIEWSRENREALEARGSNLEFELCRLQFVWLYHGESDMSGGNHVPGNWRAAMAYAKREFHTFLPRYIREVQQLMGAMAFCPNLHGSPYSAIFNNTSAWDDVAQFFTREFCSLLGLSADSPLYIAATAGAIALPTLLKLQTIMKAKRTEWTSENELPVEIPLPPSYLFHSIFVCPVSKEQATDENPPMMMPCGHVIAEESLKRLSKGSRFKCPYCPNESHMKDARKVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ81</accession>
    <name>A0A1Q5UJ81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_1896</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ81"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="400"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="836" mass="90228" checksum="E84499FFE0926991" modified="2017-04-12" version="1">MQLVPKELDKLTIAHLGFLAQRRLARGVRLNHAEAVALISSVLHELIRDGHYSVADLMSIGKTMLGRRHVLPSVVATLVELQVEGTFPSGTYLVTVHHPISSDEGDLERALYGSFLPVPSREAFPDPDPEDYVPEKMPGAVIPAKHARIVLNDGRKRIRLKVMSKGDRPIQVGSHYHFIETNPQLHFDRLQSYGYRLDIAAGTSIRFEPGDTKTVTLVEIAGNKVIRGGNWLANGPVDLSRADEILTKLQAAGFAHVPEPMADSALIAGFSMEREAYSRMFGPTTGDLVRLGLTNLWIQVEKDMTSYGDECAFGGGKTLREGMGQASGRSAAECVDTVITNALIIDYTGIYKADIGIKNGLIAGIGKAGNPDVMDGVHPDLVVGSSTDVIAGENKIITAGGFDTHIHLICPQQVDEALASGITTFLGGGTGPSTGSNATTCTPGPNHLKNMMQACDTLPINIGITGKGNDCGAISIEEQIKAGAAGLKLHEDWGSTPAAIDNCLALCDEYDVQCMIHTDTLNESGFVEQTIDAFKGRTIHTYHTEGAGGGHAPDIISVVEHPNVLPSSTNPTRPFTLNTLDEHLDMLMVCHHLSKNIPEDVAFAESRIRAETIAAEDVLHDIGAISMMSSDSQAMGRCGEVILRTWHTAHKNKAQRGKLEQDQGTDNDNFRVKRYISKYTINPALAQGMAHLIGSVEVGKVADLVVWKPSTFGTKPVQVLKSGMIVVAEMGDPNASIPTIEPMIVRPMFGARLPSLSIMFVSQASIDNGVVQSYGLRKRIEAVKGCRTVGKKDMKFNDAMPKMKVDPESYTVEADGMLCDAEPATELPLTQAYYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK62</accession>
    <name>A0A1Q5UK62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK62"/>
    <dbReference type="OrthoDB" id="5410926at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013157788" evidence="1">
        <location>
            <begin position="20"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="259" mass="26106" checksum="FF5B5E138562B879" modified="2017-04-12" version="1">MRASWWIGVWASFLPSVLSIETAPFSAPQTIESNKRAFEVLQVLRRADNNCPTGYNPCTSLGNSSACCRQGTTCSRDAANNIACCPTGASCTGSLTGASTATNTGTSFIFPQGATAATTTTTAASGGASITGSTISGAYPFINVPTTFANAATCSSYYSLCQSEYSQCTAQLMGRYGVTIGGAGGAGVTVEAVTATAQATSICSSLSQQACHGLQLNYCATAATGTANAASGNGALPVRTTSLHDLMLGLMVGIAGVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKR0</accession>
    <name>A0A1Q5UKR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKR0"/>
    <dbReference type="OrthoDB" id="4526473at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="219" mass="25198" checksum="41DAD6DCC2DD3EB8" modified="2017-04-12" version="1">MSTTNKPTPGESPRPQSKGTGSALMAGSLVKPPYNPYAWFEGDNLSPTQAALRMSNEHLERRLIKLQVNSARLQRELLLLQQHIKEFHHPLFETWEADILTRFIEVAHAYQARKLATGVSIGEDNVAERECISRGYVNAAKHVEEETVERLGLSEKYHQALLRYEEVAAYRSPNPFQTETPFARWLIEEKENRPEKYAFWSKLYPVCYGRSVERSASMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX9</accession>
    <name>A0A1Q5UKX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent protein deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKX9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="327" mass="35876" checksum="CC618016D53C3230" modified="2017-04-12" version="1">MASKAKKVIAAPSTDIQSFTEYLKGCRRILALLGAGISAASGLPTFRGAGGLWRQYDATSLATPEAFEDHPGLVWQFYSYRRHMALQAQPNKAHYALAELARRNKDFITLSQNVDGKFHCLSQRAQHPPEQLNLLHGSLYDIKCTSFYCNYTRQNDFTDPIVPALDIPKQSSSPSPSETDKTGEEASKSLHKALEETIKAKEVDISDASNPIPELSPADLPQCPECKGLLRPGVVWFGEPLPTDTIQNVDNWIESAPVDLILVIGTSSSVYPAALYVDVARNRGAKVVVVNMEKDMPNRGQGTCDWFFQGDASIIVPEILKSVIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL46</accession>
    <name>A0A1Q5UL46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Digeranylgeranylglyceryl phosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL46"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202789" description="Digeranylgeranylglyceryl phosphate synthase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="33549" checksum="9DF96181E1ABDCB6" modified="2017-04-12" version="1">MAPPKEASSALSLLLLIWHFTESNFPTFVLPNSAFGLLAALAAPLLTDCPERPSNWTFLYRALAVIVFNWANVFVFDLANQRLPESRLEDQLNKPWRPLPTGRISPETTRRWMLITIPIVLTVSAILGVATESAFIMILTWLYNDLRGGDEIIRDGIIACGYALYLTSSLRIASGLGYHISEHGYRWIAMMSGVILTTMQVQDLKDQAGDRTRGRKTLPLVLGDTVSRWIIACFTLFWSISCSYFWRMSLWGYALPMLTGIGVASHVVSGSHDTRAWRCWCAWQVVVYALPWLASMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL54</accession>
    <name>A0A1Q5UL54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snRNP-associated protein usp106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL54"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL54"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="281" mass="31233" checksum="DB69C932B5A8AE09" modified="2017-04-12" version="1">MAAEQRKLLEQLMGADQLIGTGAQGRNSQLSITDAKVCRSYLVGTCPHDLFTNTKQDLGPCPKVHSEGLKTEYDTASSADKAKWGFEFDYMRDMQKYIDDCDRRIDTAQRRLEKTPDEIRQTNDLLKQIADLNNTINTGLLEVSVLGETGSVATALTEMHKIRTAKHQKENAERDLKNLQDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFFGKMHMGYSDMRKGFKKLSAELKGRAPPVRHHEEEDPYAAGGRSGGRGPRYGGGGGGGGYRRRGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULM9</accession>
    <name>A0A1Q5ULM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinetochore protein mis13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULM9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULM9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="486" mass="53666" checksum="F2775DBF86BE0AE0" modified="2017-04-12" version="1">MITGYDEDADGFQFSLLPSKKPKPSVAVAPHLAHSDVENTTPKPSPRRGRPPKKRAEEHAVPAKGKTADLPTRRPTRGSTRAVDAEAESHAESAARSSRNQESHEEQPSERKKKRGRPAKAKTNESNGYHSPEQPPPGIKVALPTADTPVIQRNKEFRGAKSSKGGRRSSLQMRGRRASDLIDSGTSNALPHREVSAADFYKHIADEGLPEPRRMRQLLIWCATRALPDKPSGSHSEEISARLAARAIQEEILKEFSSNSDLSNWFSREDVNPPTVVVKKPNPRNVQNTDKIKELEEQIQKLQKERHALNALLKQPAIPRIDVESPKKSPKKSPRSKRQSEKPSINTSLLDPSQQAIYATLNPTSSSSTASQLHPQDAASSTQPPMPPSTVSARLSRITTALAPTLDTLAAGVHDIELYRSTADAVSSQILRICAQRLEERDARNTQQRLAIEGEDSEQRTPRVSRSRPREDLGLILGALSRVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM73</accession>
    <name>A0A1Q5UM73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extradiol ring-cleavage dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM73"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="7">
        <location>
            <begin position="99"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="369" mass="40832" checksum="BC675CDE2A615AA4" modified="2017-04-12" version="1">MSSEARQQNTPPKNHFAPLHTNNRRLFLLSVVTVFAAALVAIFWPDTVNLFAFRRFFGSSSRTAAATSSVAGSLSAPALASSSGIADQSEVKMKTPVYFLSHGGPNIMYNVDHPAYKKLNQIGREITTKVKPRAVVVFSAHWQGGRDTIYVNTAEETDLIYDFYGFPDHYYKEKYPNVGSKEVSHKVLDALKEAGIEAKGVKRGLDHGVWASFKCAFEPDSNPLNVPVVQVSLFDTEDPNQHYRLGQAVSRLREENILIIVSGMAVHNLRDLRFTFGNPRPMPYAVSFDEALKDAATTAPAEREKALTDLLKRPDARQAHPTFDHLLPIHVGAGAAQEDVGKRIWTLPEGSMSWAQFRFGELSNASTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMH4</accession>
    <name>A0A1Q5UMH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_887</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UMH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="104"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="929"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2120" mass="234952" checksum="45FA44E7024C536D" modified="2017-04-12" version="1">MDQAMLDNSDSHRRRQPLADASSRINYTKASNVETPRVRIENLDQLKTLDCTSVSASPTPQGNKENQRLSVATDFQSESARNSVVSAASILSNKGKRKTHVGPWQLGRTLGKGATGRVRLAKHALTGQTAAIKIVSKKSAAMVQSESIAAMDRTASTFTGSSNTRQMPCGIEREVVIMKLIEHPNVISLYDVWENRGELYLVLEYVEGGELFDYVSNHGPLPEEEAVRLFRQIIAGLGYCHRFNICHRDLKPENILLDGNHNVKLADFGMAALQPVGQWLNTSCGSPHYAAPEIIYGRKYRGDRADMWSCGIILFALLTGYLPFDGGDLAKTLRLVKKGEYMIPPELSDEAAHLIQWILQKRPEDRITMQQIWEHPLLTKYEKLHNAMADYYIGPPPPLSIKDCGEPVTSRQDVDFDILRNLQTLWHDVKPDALIDRLMSLEPTHERMFYNALAKFRDEQLENYQGQPLEYSASDYHHISRPGDRVRRGRSSSKRRSQVSLVRDLHRRMSSTKEPKSSASIESYDPYRSPKTRTSAKEAQYSQITIHKAPEIPECGEVSPVVKPPPSIVEEEEPEDNRDAGGSPFTVLQKRKHKPSSMRSFQSSKVHNSSSKYPGLSTRSTSYRRNVSFQHVRNRSQGSTKPKRRRTGTNQHSDLKRSPSAASLQMIADGLVVPEIPSSPPLPAQPTVVRPSGAKAKSLSRERKAYQSDIIWTEDARKVSNELSKICEEAFNGSSLTTMRVSSSATGYETPATPVSASSPKQRPTIPVIQPLATPKGAPTESGRSYSIQELTETRRKLVEHSKGGSDTIPAYLSGVIGHLDRLIEEDQSHDQSRRNMEESTSTLVDPFYGGTEDTSLPVINEEFASPIRAPSEYSPMPKLQKKRGPPAAKARANDAKQTIRMVPHSSLRSLEEVKPLMIRKKVQITDSDAVNSDSAEATRNFSQSSRQSRHPGGLDPIEEVPVSPKKTTDSKKWSWFKHRPQVSENPLSLPVKDFKPINPYNGTAIVNPPQDLSQPETVLPIKVPLEQKVPTRKSSMERFGGGFLKKLMPKKSNKSLSQPETGMFSCLPYRHIMLTSQEDLEKPKARNSAMLCNGLPDTESSFDSVSALNPPRNKRLSLANQNWFARVFQIKPASRVIALNTSKVKGRKELYKMLREWKEYGMENVYMDKTNSVVHGRVSEVNFLRLREVEFIAEFYTVLEHGRQANLSLVRFKQERGAASSFNKVVDTVHMMLQNRGLVVEDPVRAKKMARILDTVPSSPMRVGIELVSWLSLGVGALGAAQSNVPWPAIPKPQKATSTTTAVTVYPSSIKKGLSSEFANDSAENALVFQSVGEIYTLDYGSDVAGKPIFHVQVAEGNPQIEVKYTEAYPGLLKAEGDGPFAFANALAATFRVETFNITKTGDLSGYFIQGSQRWQSIKLISGKKLVIQRAGFVSSVDQSPLSSMPGYFASSNSTYTDIWALGPRTQQLVCYPPNSQTSTWEITSNGAYIRGQKPATTARVVNLSNYTLSFETMIDHGGTGWRVDTEIDAIQATGPIFVLTSEYPTGSFANIDKSLLPPNTLVLGRGWSLQNQTSLPGYVLDKFPLTFNVTEKTWHTIRTVSPGDDTYTVYLDDQRIAHFNISAYGIADPNPYIPGGVYKSFAFGPWQDQAAYVCNVNVTLSNGENVYSNPMTSPDVLTEYGVQTNAQYTCSDSGKRDRFSWLGDRLISARTVMVGSQQGEFVWGPAEEAFSRQVGSGQIPINTLFSPLDAEGALIRTTNVDPLIVDYDFDFMQVIYDYWTRSGNGTFLEKVWPRMVMATSYALSRSLDQKTQLYGAPYGSTGTRMSGEKGQALGPANTVSMIIGLERMSEMARFIGDDGAADFYQVQAQLSRTAIDTLLWNETAGYYAATLGGTGSDLMDIAQVLLAGIGSEQRQESFVEKLSALRVTAGYINGTRFLDTPGVVDPYYESFLLEGLASTKRTKLAQDLLDATWAPMVNRDRNYTGGYWEYISTDGTYPGLDLFTGMSHFWGSYPTVFLSEYALGVRPTKPGYNTFLFAPLPGFKTKWVHGRVPTPSGIIYAAWGYNKQGKIVMEITAPSGLRGTLVPPFTGSYSVGSQKGQLGNYTITGGATVLIVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNH9</accession>
    <name>A0A1Q5UNH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNH9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="482" mass="53846" checksum="759585181DDCBE9C" modified="2017-04-12" version="1">MAQSIGLQRQYLRGEPEDIEERKRVWWTIYTWDRFASITYGRPLGINDKDCNLQMPSDILENPRFIGSGSRQDGAICYSTYQRELNRLYLIASPALEAIFGSRTFRTSEQLAGDSYFALVKQATKKLQEWRHCLPTHLSLDLKKDFLPDNQASSRAYALQSLSLQLTYDNVLIVLHRPLLARQVNQLSTMNKRSPAGIAADSPTYPSVTSAHSAGQSGSYFDSVFSGTRVTSSELWMDAAVRTSKITELPVLVRLATESHLVAFLAINLFHAAIVLAVLALSEPLSDIAQEVKRTITRIFRVQDLIGKRSALSKQSTFVLKNVVALLLRRESEAMLAPVTGTSEAISHHTHGTGPDSFQISVEDALQLPVDATLESRHSLAMNEIFSDVNRLHRLNESLASVQSALGPGDDRFSGLPPGGDFPRSHESVQQNEHSNGMWRPSAQDWGVTGNVQNTGIDNLYHENMDGGLYWLWDMTWNEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNW6</accession>
    <name>A0A1Q5UNW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNW6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNW6"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="53625" checksum="3CE685BA34E52433" modified="2017-04-12" version="1">MSLASLPPELLQMVARAITDTRQGRSQPSQTLKTIYALSRTCRATYLHLCWNLYRYDADRGHSTALVWAAVTNNPQTVRLSLASGGNTRATNQHGQSSLWLAARRGHREIVEILLDHGADIEIRNPVGLTPLAIAAREGQCEVMKVLLDRGANHAAQARDHSTPLLWAIRNGAVDAVKMLIEHGAQFPEPKTTHRRRWALAAYRAGPDRWADIPEIETLMESSYDGNQNKLLSQKPLLNALRFQHLAMSTFFLDQCITPVSDLASFFGYSPADEPVHDKTRHGREQVDFTREKAREQWHYFGRPDDNPMWWAVQHGEEEIVEKLLRRGAGTNSLRHWSPSIGQEPRNLIALAIVRGYYGIAERLLDYGTDPSYQFHDGPLLRRVLEIGNERLVMKVLLSLKRHGAHNIANYGGYVAIAIGKKNAMLVKMLLEFGADPNSKVFYHRGTESGSRHKALLSLAIEIGNQDVVDTLLEYGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPH0</accession>
    <name>A0A1Q5UPH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_14154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPH0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="72"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="29657" checksum="3A6ADC045B024DAD" modified="2017-04-12" version="1">MAETKIVPLSAPRITPANSKQAEISYPRWFGGSASCMAVMVSHPFDLMTYGASRIALYEELKYSAKKSEKPVTTPMLTMMAAASGFVGALFGTPSDIANIRMQNDRSLPIQHRRNYKHVLDAWVQMKRHEGWRSFTQGLWPNCFRCGIMTASQLASYDTFKTLLRKWTSVSAESPVIHISASLLASLVATSISSPMDVIRTQLMSASKRVSVLRIVTDLTRSEGYRWVFRGWAPSFVRLGPQTIATLVALEQHKRIYRIFKCGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPK4</accession>
    <name>A0A1Q5UPK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor RLI1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-binding cassette sub-family E member RLI1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_14180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPK4"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="70"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="327"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="604" mass="67852" checksum="27EE020D11E5508B" modified="2017-04-12" version="1">MSDKLTRIAIVNSDKCKPKKCRQECKKSCPVVRTGKLCIEVTNESKIAFISESLCIGCGICPKKCPFGAINIINLPTNLESQVTHRYSANSFKLHRLPMPRPGQVLGLVGTNGIGKSTALKILSGKLKPNLGRYDNPPDWEEILKYFRGSELQNYFTKVLEDNLKAVVKPQYVDQIPRAVKGPVQGVKDIIKARVQLDNMKEIMDVLELNQVADRDIGHLSGGELQRFAIGLVCVQKADVYMFDEPSSYLDVKQRLAAARTIRGLLRPDDYVIVVEHDLSVLDYLSDFICVLYGRPAVYGVVTLPSSVREGINIFLDGHIPTENLRFREESLTFRLAEAGDDFIADKAHAYGYPAMEKTLGNFHLSIEAGQFTDSEIIVMMGENGTGKTTFCKMLAGAEKPDGNRSVPKMNISMKPQKITPKFQGTVRQLFFKRIKAAFLSPQFQTDVYKPLKLDDFIDQEVQNLSGGELQRVAIVLALGIPADIYLIDEPSAYLDSEQRIVAARVIKRFIMHTKKTAFIVEHDFIMATYLADRVIVFDGQPSVDAHANTPESLVTGCNKFLKNLDVTFRRDPNSYRPRINKYNSQMDQEQKLAGNFYFLEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPQ8</accession>
    <name>A0A1Q5UPQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Crossover junction endonuclease eme1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_14072</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPQ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000010">
        <property type="entry name" value="Crossover junction endonuclease eme1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="337"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="669" mass="73983" checksum="F44A13B812DB4E69" modified="2017-04-12" version="1">MREVIDLLSSDPPLPETSRLQHALAPARRAGVRLGANSRLISSDFVDVSTFTDDFQDKPAKKRRVSAEKRPPVRQSTVAQGSSRPGPSLFSFSDDDFSLPPSNPRAQKKYLGRDVDESDPIVFTSSAPEPSKKQHSTWSKPNHSQAEVITLDDDDDDLWKPMGNGSSSRGKQDEIQEFSDPFGCAEFEDSFGLSGPGVSASTSGFSSKTAALISALSTAPKGNGNRSNIKSGSCSQKSKGATMDATLIGDFSDEVDGPAPRQPAKKSGKLTTEEKEARAKARADAKAQRDLERQLERQIEKERKQKLKEEKAKEKQLASDIAEVNKLKVDKKDSTGEMILDISSSFEGSSVGNQAVEFMKRLKVEYHFFTGPVPNVVKWRRKMKARYNADAGHWEPAAFHILEEKHVLCLLPAQDFVDMVIDYPPGEEKESLDMHVLKIKSAYPSCKIIYLIEGLIPWMRNNNKSRNRAYVAEVRAQFEPEPPTSQASAAPRRGRKPKRKPETTPPVDDDTIEDALLALQVTHSCLIHHTAAPPESAEWIKNFTEHVSTTLYRQERMEAHDAAFCMESGQVKPGDDKLDTFVKMLQEVNRVTTSMAYGISSQYSCVTDLVRGMQMHGPTMLEDVKVGHNSEIALRYLGLLWEGSAFQSVTIFVGSLPVSGPGQLARSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQS4</accession>
    <name>A0A1Q5UQS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQS4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQS4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="194" mass="21537" checksum="39DDC6DD323D6F51" modified="2017-04-12" version="1">MSLKRKASFPGLPSSLAISTPSGWGMSDSSKDLPSRTRKRFRNGRPDDDVVYEKTLRWIFSAQQQQQQQPITPMDTADDAMMDADPSIPFPETVDPRQQTLLRFFQPRAEAMSPFRPSREALAARANETALDKEEIMRHQAFSQMNMAGSTSGSETTSPGFFQTETDVDMDMDGGESSDSSNPVAKWGFWNGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR37</accession>
    <name>A0A1Q5UR37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ABC1-like protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR37"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR37"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="391"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="746" mass="82093" checksum="AF611FFBE73DBA74" modified="2017-04-12" version="1">MSGRRVLDAIQFLNVSKSIALKHLAIRQHQLDVYTRTSSLTKGIKDQTEGLILTAQAAAALARRLNDEPSPPPPTSSAPSRSPTTLVAEPSADKPTSSQTTATATSPAPETARILQRQAEFQVPGSTAQSKGDEKPDNLNISPQQEVYYQPSQEAAPDFSALPRVKLPKAVGDTQVIGQDGLNADVFNSATAPERPNAPAEQQELSEEMMQSLFHSPRVSRMLSGKPAPAPAAQRQWPPADRDRFVQQELAEATPAPDADAKTAAKSEVKEIEKLVASVAEDVTSPAAEFVMGEKPAPYQMMESRVPSSRLGRLWQYGGLATSMAFGAVTETVRRATGSQDSGSIMFSAGNMERMVAKLSKMRGAALKLGQMLSIQDSNMLPPQIQLVLQRVQDRADYMPASQRDKVLADNLGPNWRDLFTSFDEVPMAAASIGQVHAAVLKSTGRPVAVKVQYPGVADSIDSDLNNLSILLTASRLLPRGLYLDKTIANARTELAWECDYLREAECGARFRKLLKDDPVFVVPEVMPEASGKQVLTMEMLEGVAVTKIQDFTQEQRDWIGTQIMRLCLREIVEFRYMQTDPNWTNFLYNARTNRLELLDFGASREYPEEFINKYVRTLVAASRNDRTACHDLSVQLGYLTGMESQAMADAHVSSIVTIAEPFMLSSPDVYDFRDQTITDRVRALIPLMIRERLAPPPEETYSLHRKLSGAFLLCARLGSRVPCKELFAEAVRKAEAKGLDLEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR70</accession>
    <name>A0A1Q5UR70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR70"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="435" mass="47234" checksum="F65F52EB945AAB95" modified="2017-04-12" version="1">MGEVFDVAVIGAGMAGIIAARDLSEKGYKVVLLEARGRLGGRTYMDHACGGILELGGGYVHWTQPHVWSELQRHGISLDPPMEEGKNYWLADGAVHTGSSDKFYATAMPLLERLFSDSRARFPMPFIPTAIDNTEIEKESIEDRINSLNISSYERDVLEGALSGVVHSYKDHGIAQLLHAVATYFGNFAAFFETAGTWSIQGGTKGLIHAIMAESTAKLLLSTPVTSITDEGSRVIVGTQDGQQIHARKTIVALPLNTIGDVQITPMLPVMARSMIAEMNPTMAGKLWIRVRGEIEPFSIYAPAGKYPLNAARTEKYFDGDTLVLCMCSDDASIRGQDRLGVQAALRKFIPNIEVVDIAYHSWVGDEYSKGGWMMNRPGFFTTGAVELRRPHGNIHFAGSDVSASEPGSIEGALSSGAQAARDVSIKLTKQKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URC1</accession>
    <name>A0A1Q5URC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URC1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000451">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000721">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="19"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="561" mass="61958" checksum="60B1470CF7FC3FFC" modified="2017-04-12" version="1">MTESFPAALAGPTSKERKYDRQLRLWAATGQQALEDSRVLLVNSDGPIGANSTGVSGVVGVEALKNLVLPGIGGFTIVDPATVTESDLGVNFFLEEESLGKSRAEETCRLLRELNPDVQGYSYSKHITELLNDPDFLPRHKLVIISGPTNRSSLGSLTQQAQRLGIPVLYVHSVGFYSTFSLQLDAEFPIVETHPDPETTQDLRLLNPWPELAAAAAGLEDLTAMDDHKHGHVPYILLLLHFLEQWKQAHEGNAPGSYKEKTEFREFVRSNTRTDNAEGGEENFDEAVAAVLKTISPFSLRSSTREIFEMEQCKQLTPQSVDFWVIASAISTFYTTHGVLPLPGSLPDMKAQSADYVALQNIYKSKARRDVEEVTATIRQLESQLGRSTPQILEREIEVFCKNAAHIKVVHGRAVPQISSDSDSMTLKAIRNQLNTPDSLISVFIATQVLDAVVDEIQSSGQQGIQLSIDDEGLWTSHTERILALLSRDQPVPLDEDVRESIDNAIQELRRAEGGELHNISSLTGGLVAQEALKVLTRQYVPLDNTCVFDGARSRSEMYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URC4</accession>
    <name>A0A1Q5URC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GPI-anchored CFEM domain protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_3417</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URC4"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012095418" evidence="17">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="97"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP15022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="19613" checksum="8B1FF27DA805C584" modified="2017-04-12" version="1">MKFSTTLIALVAAGLANAQLPDVPSCSLSCFVTALTTDGCSSLTDFACHCQKPQLVSTITPCVQKACAVSDQISVSNAVVAQCSSAGHPISVPPIETATSASSTSSSSSASATDSSSSSATATATGSGSSSASASSTATGGSGSSSSSAAGSTGAHGSTPAGTSTPLPSKTATGTAAGATTSPAFNAAANMKGNMAGVAAIAAAAAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URJ4</accession>
    <name>A0A1Q5URJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URJ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF27">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="1">
        <location>
            <begin position="145"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="72641" checksum="FAC67580C45C7766" modified="2017-04-12" version="1">MSTLILEYQLTGFSQYLPGSPGDANGQFYTGGEIQIEDDGKAYSGYGTYVGGWNNGAPFTVYFWGEFAENADNVRTFSGINTDPIPRYHNLANGGISEPIYGNDTRKAVSGPMNNRIGVLFSWKEGPASSITSRVGISSISTERARSYIEKEIPSWKLNDTVKDSVKEWNDDVFQKIQVPLDDSANMTHVRLLYSSLYFMHLMPSDRTGENPLWNSGEPFWDDFYTMWDIFRCTVSFYHIFQPEYYESMIRSLIDIWKHDGYMPDGRSGNWNGLVQGGSDADNVLADAYVKGLRGAINWTEGYLAMKKDAEVTPYNTFDPTDLTASTKEGRGALDDWKELGYVSEDHNTRCISRTVEYSLNDFAVSQVAAGEMPEDREKYLNRSAGWQKIWDSSVSSLNFTGFLAPKLSNGKFNSSGYDPLYCYDCEWSSYTYEGIPWEYSFVIPHDCETLIELMGGPETFESRLDLMFKPNMSVQNLGANGAGITTLINIGNEPDFATPYLYNYINKQAKSVERSRSLADQYFKDAAYGVPGNSDAGAMNSWLLWQMLGIYPIVTQPVYLISSPWFPDLNMTVSGNKTLRISATGLVNGYYVQSVKINGKKWTKNWFEHDDVMTNGGHIEFELGQDAKAWESGEVPPSPGHVQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNZ1</accession>
    <name>A0A1Q5SNZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNZ1"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="632" mass="71093" checksum="606195F0CD1094AE" modified="2017-04-12" version="1">MSGNSGNPPGNPGNPDSSRNLRNSGNYDYPPASVPRLPRVHDPRLSEQSFRERYPHTQDLIDTLNAQHTRLTSDTTSSPWLRLIENVGNGETTESLSELLRISEEHMNQSGGLLQENQRPTVPARPSTGDRLHYLRSLLYSGSNRSNADETTRALETLNREIEDHRLDQAARNSASESREEAVSFNILRPPQIDFAALRSSHRTLWDQVRAEFGINAQSPARSNPYQDPPRPTTSSRSLRRRSFRPDLRGASNLDETISIPPLMPQSASASSGRDGRGRLKRRKLDADDNREGFRGFNYGHSGQVVSGPLKMEIASCDGGTFDPDGDSSFPDNVLRNDQSVYCTKSDRCNIVLRHRDEAPFCLKKIVIKAPRTGFDSPIQEGMVFVSMTSDELLARTAQYQLQYPSHRRRRRNRRYGLQPSQEYLTAFRSPLQSLDRTPMGPSSHATSDNENADRNANDPQAEFRITTDYDEYPEENSFMQREDDDGPSVAELERIQEDEDICSESEDSISEDDDLDDSNMGNVHRRRIELQRLQSMQRRRPASLVNPIPPPSSAPAGSSGASSNVEVLKPHARFFIEREKSMVSIKFDPPPSGRFILIKLWSPRSDGNIDIQSIITHGYAGPRFFPSGGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP73</accession>
    <name>A0A1Q5SP73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SP73"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="27076" checksum="BB31EA1BDBFFAA79" modified="2017-04-12" version="1">MASNEPVPSPAQGVGPIGQPDGEKPTATVSKEVSYENVHVLAQTPQLIALLTMIRDKRTARADFIFYSNRIIRLLVEEGLNHLPVVEQSVTTPVGRAYLGVKFEGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETCMPKLFYEKLPADIADRWVLLLDPMFATGGSATLAVEVLKQKGVPEHRILFLNLIASPSGVAEFAERFPKLRVVTSFIDQGLDDKKYIIPGLGDFGDRYYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPV6</accession>
    <name>A0A1Q5SPV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TOXD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000764">
        <property type="protein sequence ID" value="OKO89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPV6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPV6"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF7">
        <property type="entry name" value="ZINC BINDING OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="38214" checksum="3FE4A307B06DE5FD" modified="2017-04-12" version="1">MKALISNRRIATRIFNHASGKSVGGQGGKVKDDVPIPTISPNEILVKVKAVALNPTDFKHLDVISPPHSIIGCDYAGVVQQVGSAVRFGWTPGDRVAGAVHGGLFPDKGAFAEYLKVDADLAWKVPDEISDTDATTYGVSAVTAMLTLNVRHGLPFVQGDQATPKDEVIFIYAGATSTGLFHIQIAKAAGYEVVATASPRSFDLVKAYGATAVFDYRSATVAADVVKEYPKISKAVDCFSEGKSTSVCAEVLKNTGGTVVTLLPNGKSSIPGVSYEMVMAYTVFGHPFQWLPPIGPKFEAKPADREALVRFYNVLPTITHILKPIPTVKEKDGFEGILDGLNKLRAGAVAGGKLVVDFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRD2</accession>
    <name>A0A1Q5SRD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRD2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11386" checksum="0F606F7E7551AE72" modified="2017-04-12" version="1">MSRSADFRMEALLKFIHIAAIQFEHFGLSQYSSPCEHDTCNRRMPPTAKPVQGYPDSLSGSALMLKLKYGSVNLYTFGMAGMLWSFLYHLSSFHDAMSTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRV1</accession>
    <name>A0A1Q5SRV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRV1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRV1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13667" checksum="CA6FCB78B88B935E" modified="2017-04-12" version="1">MAVTGYFLDKDWSYRELLLGFEPLHGTHSGTNLSAVLFQLLQKYNLTDRVLAITTDNASNNNTLFASVQETVQSLDLGDDAAIIRVPRIARVIQLSLKQLLGQMKANPKNDTAQMQWTESQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSC2</accession>
    <name>A0A1Q5SSC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSC2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="19908" checksum="7819218E911C9BD4" modified="2017-04-12" version="1">MGSIAEEKSKNAPLKDAENGIEGSNKDSKESPERPPSYNQPEVPIQLPQLDLKNGPVSETTQTVSPDQVVAHLKFIAVLADLRDFVSNNDGLFGLFDSQADKYPDSLDEARVRIREKRWAVYTARAADRYQKWWSACLPVSRSHVTMQDLTADNYEDVLRCETKVLWSVETMPPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWA0</accession>
    <name>A0A1Q5SWA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012999409" evidence="2">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="13424" checksum="BA7F0C982CDF273D" modified="2017-04-12" version="1">MTVHLVVVLFLRIRCYFVYHLIIRPLPRSCDIQPASRPAHECPNEEHPSPLDGRLNLPVRQIHEGIDTGKDIANQGLDIGVGMARLGAERDTGGDGAHDPEYRIDEAQSLWEVSHVLPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWA6</accession>
    <name>A0A1Q5SWA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Opsin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_12860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWA6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWA6"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO92298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="33190" checksum="2E8BFBE6A1D3F74B" modified="2017-04-12" version="1">MMVPNEFDFFPKATGTLPITTPTSVAPIPTVIPSVPIFQDLHDTGKRTLWVVTVLMGVSSLVFYALAARAPLSKRVFHTLTALTTTLSFITYLALSTGQGISYKSAHITHHHKHVPNTTDIYLRQVLWLRYINWALSTPLILTNFALVSGLPGGHLFAAIAANFVMLAAGVLGSFAGHTKVRWVWLVISCLAYLVLVHHGGFHAQRAAGNKDVRTKRFFAALSGLAFFAFALFPISLAAGSLALKISVDVETVLLAIQDIFTQGLLGYWLLVQHDSAQGITLYVDGFWSSGVGNEGAIRITEEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXD7</accession>
    <name>A0A1Q5SXD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXD7"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000020">
        <property type="entry name" value="OTU-like cysteine protease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="161"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="324" mass="36814" checksum="2D1E55689BE76E5C" modified="2017-04-12" version="1">MEELLATHRKEQKDLQGRITQKKKSATKKTRKGVNDDCERMQRELTERQRAEIAELNGDSTEPVEEALEDLNLEDGTPTEDKSDDDKTTSTTQAPEITSTEPSEEPTKRTKKPNRQKARLARRAAEQAAQSAAAAEEAANQTNYRGNEQEVMDAVFKKLNLREVEVTPDGHCLYSAIAKQLDDCGVGLRPDPSRIVLQPSTQTRIDTVASPQHDGYRAVRAVAADFIREHKEDFEAFMEEPVDVYTRKIKLTAEWGGQLELQAIARAYGVDINVVQKDGRLEKIECGDMDSFNEEEQRRRVVWLAYYRHTYGLGEHYNALFKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZE9</accession>
    <name>A0A1Q5SZE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine palmitoyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZE9"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000004">
        <property type="entry name" value="2-amino-3-ketobutyrate coenzyme A ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="249"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="675" mass="74215" checksum="F7A4FE3745D02CC3" modified="2017-04-12" version="1">MPRRFSNNPSNDTSTNSPSFSPSLGKGGIAIKAPSVKSNRLSQLFSSSPKNKESTLVTSLSTSGNNPNNAPPPISSASLSLPTISLSTATADNPAMDEMPTTLFQPPTPEEARRQAKAHAQFGVIGHPSHRYSSQHPGGDFPEPVMDEPPYYYLLTTYISYLILIAFGHVRDFFGKRFREENYRHLKPRNGYGALNSDFDNFYVRRLKLRINDCFERPVTGVPGRTITLIDRGTNDHNHHFHLTGTTTDTLNLSSYNYLGFAQSEGPCADIAEDTVRKYGIATPSTRAEAGTQDLHVEVEDLIARFVGKEASMVFSMGFGTNATVFPALVGKGDLLISDELNHASIRFGARLSGASIAMFKHNDMKDLELKLREAISQGQPRTHRPWKKILVVVEGLYSMEGSMCNLPGLVALKHRYKFNLFVDEAHSIGAIGPAGRGVCDYFGIDTAEVDVLMGTLTKSFGANGGYIAADKVMIDKLRATNSGIFYGESPAPAVLMQISSALRIINGELVPGQGEERLQRLAFNSRYLRLGLKRLGFIVYGHDDSPIIPVLLFNPAKMPAFSHEMLRRKISVVVVGYPATPLVSSRARFCVSAAHTKDDLDRVLTACDEIGNVLQLKFSTGIAGGALPPAEEMAPPPEMEKEWHRKRSANFTPPRWRLEDVIRRGVQDVKSPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZJ7</accession>
    <name>A0A1Q5SZJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin and WLM domain-containing metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZJ7"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="125"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="38817" checksum="21D9765037764E28" modified="2017-04-12" version="1">MDLTVHHHGTPHSVQLSDSATLQDLSAEIEIILNIPTENQKLLIAPKPGMQKAPFPPTQLSTILPLDSPKFKITLLGHPAKAIADLHEQSDSIRKRQEARASALAAARRANHKPSPSNRGGIHTLSASTTNYTFHRLLPLSYLPRPERSLEFLKRLRDDPGIRAAMTKHKFSVPLLTEMNPAEHTTSESRTLGLNRNKGEVIELRLRTDAYDGYRDYRTIRKTLCHELAHCVFGPHDRDFWDLTAQIEKEVERADWKMGGNRLTGQDFYDPGDWERVQSGEEVIDEQGWTGGEFVLGGLGVDEAGRSAGGNGSGAASAAATGSLSRREILARAAEERMRKESPKEKQDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T002</accession>
    <name>A0A1Q5T002_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T002"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="110" mass="12407" checksum="23A9383145AD57AF" modified="2017-04-12" version="1">MYPALLKHQIVKPSAFHITRIARASVSGKTQPSAKGSEEYDFESTMKSDLFQEQSPTMKSQTTPEQFSAADIERHKADIYESISPKKTSGFVKKQDSQNLPEQEPNLDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0X1</accession>
    <name>A0A1Q5T0X1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0X1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0X1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="97"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="419"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="533"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO93883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="652" mass="73712" checksum="2B489DAE71E17023" modified="2017-04-12" version="1">MDPAKPVELPERPKEAQPAAEPQGEPKQSKAAAKKEAKKAAKKAAQKENSSRPKENKPKPAKAPKEAAEARDPDAMFKVGFLHDVYNERPLSETIPKIRTRFPPEPNGFLHIGHSKAIAINFGFAKYHGGECILRFDDTNPEGEEERYYNAIRDIVNWLGFTPVRETCASDNFDKLYELAEDLIKRDGAYMCYCTKTEIKAGRGESESGQRGGERFACAHRNQDPEKSLAEFRAMRDGKYKAGDACLRMKQALLEDPRAQMWDLVAWRITESEEKAQHHRSGGTWKIYPTYDFAHCLCDSIEGITHSLCTTEFELSRVSYDWLNEKLDVYRPMQREYGRLNITGTVLSKRKIIKLVKEGHVRDWDDPRLYTLIALRRRGVPPGAILSFVNELGVTKAVTNVQMHRFDQSVRVFLETTVPRLMVVTEPLKVIIDDLPDDHEELVEVPFGKDASFGTHSVPFTKTVYIERSDFREVDSADYFRLAPGKTVGLLKVPYPITATSFEKDPATGTVTVVHAKYEKPAEGETAPRPKTFIHWVGESAKHNSPIRAEIRAFNSLFKSEDPSAHPDGFLADINPNSEEIYKHAMIETGFNEIRQTAPWPKAAGEADVESNLHCVRFQGMRIAYFAVDRESTADQVILNRIVTLKDTQGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T112</accession>
    <name>A0A1Q5T112_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T112"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T112"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="5960" checksum="AAC07550D5C7FBA8" modified="2017-04-12" version="1">MQPTQDSASDEANGKVIVLNNHEVEQFYGSSTTHAYRIKSELVGKCMEEIGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1C9</accession>
    <name>A0A1Q5T1C9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1C9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1C9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44279" checksum="30B3AC43AD6AD8AC" modified="2017-04-12" version="1">MSQAGVDPGSVPKYVGLPFSNEEMWRYHSARYYDQALGHLKIAVSSDSYSRTLLGKEEMLAAVAILCTFELMDAPGSAWKAHLSALPLFDDRAASVPVHSSIIIPQTAVKGISESPTRLDLKDMRLWQNAGLATDEKGELLPYSPSDVMETQNSSGIEEDMKSNELTWILGKIANHLTAGDALVPANNAMPRYQRPLIGLSQEHLLERWNMLMADLERWHASLPACFTATARTRRLGSAALGFELSFDTFEQIWFDLPLCAATMQSYHQAKILLLANEPQESTAIRSTVSARLRSYRHALREVLYHAREVCGISLANSTDSFRVNSVQALFVAGQVFQERNEQEAVLELLSGIERDIGWTTRYHVAKLKDEWVKGREGNHVDREEQSHDSNWFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4R7</accession>
    <name>A0A1Q5T4R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cocaine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4R7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4R7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="312"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="577" mass="64934" checksum="092D6520876F9412" modified="2017-04-12" version="1">MSLDFDPVETIFQSSKKPESAGTGYSGLDTSRVFLSEGHCRTPECRPLPVPLIWDRDVPLRMRDGVYIRVDIFRPQDSTAKLPALMAWSPYGKTGAGVAKSTLSGYEKWEAPDPVEWCARGYAVVNADARGVFDSEGHIRWLGIGEGQDGYDAIEEIAKLPWSNGRVALAGNSWLAMAQWFIAAENPPHLTCIAPLEGATDFYRETLCRGGVPFKPFWDMLRTCLVGRNLVEDPVAMIEKYPEWNAYWEDKRARLDKISIPAYILASYSTMIHTEGSFRGFEEISSKDKWLTIHATQEWFDLYSKERIEDLACFFDFYMKDCSNGWKNTPRVRASILPFNKDAMTNIPFSSWPPRETEYRKLYLQASNTLSEESTSSFSNKVSYPADLLGTQGGNESGELSFSYTFKTSKRLLGYSKAVLFLSADQADDMDVFVQLRKADIHGNLLEHLNIPLKDLKLSNINEVEQINPLKYLGPPGILRASHAQLDSTLSTEFHPVYTHRDPQKITPGQIVKLEISIWPTGISFEAGESLVLRIGGHAQVLAEFSALRGKWLSENKGTNFVHFGGEHLSYICIPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T607</accession>
    <name>A0A1Q5T607_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T607"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T607"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="150"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="578" mass="65129" checksum="2C2635A969AFDE6B" modified="2017-04-12" version="1">MAAAADVRDMLDLPAEGQPRPAKKAKVVEKRPEGITRELYALLGERAPPIAINENKYKGRPKFMNKLRVRKWCMTPFANNARSDGLVLNHWQREHESTRPPAPEPNQMELDETKEGGKDEAPKPKEQEYAFAKYNIKARVPRRYTDEEYNRHLKSDDWSREETDYLMNLATEYDLRWVIIADRYDYQRHLDSEPDANAIVPAKQYRTMEQMKSRYYYIAATMLAIEHPPSEMSEAEFALHEQMLKYDPDRERDRKELAALQLNRTADEVREEAMLLEELKRITSNEQNFITERRELYSRLEVPISVGNTAMYQSSQGLSQLLQTLLQADKSKKRRSILGPEGAIPSPVGQTPTQATALGRAETPGTTAATKDTKKGPAVPPTQPAVRTLTPAEEARYGVQHHERLQGGVQFRSDRAQKLTQAKSNVQTQKLASALAELEIPLRLFMPTERVCKNFEKLIQSVNLLLDARKVAEKVESEIRVLEAARAERERKNAPEGSNKDPEHPEVKTEADDGGNSMLGSTAADATESGVSAAGETGQAKGDEAVSTQTPVKEDGNHKRSASVLSSVSDKSSKRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T665</accession>
    <name>A0A1Q5T665_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_11238</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T665"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T665"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO95726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="372" mass="41691" checksum="7DF8C9A276A62CB2" modified="2017-04-12" version="1">MGNEESSMVDDSTRPSVLEGRNVEAVAKYIKERNVQRIVVMVGAGISTSAGIPDFRSPDTGLYANLAFLDLEEPEDVFDIGFFRQNPKPFYALAHELYPGRYRPTIAHSFIKLLYDKGLLLKHFTQNIDCLERQAGLPGDIIVEAHGSFATQRCIECKTPYPDEEMQKKVQHGEVPYCLVPQCNGLVKPDIVFFGESLPPSFFESRDLPEQADLCIVMGTSLSVQPFASLPVLCKRGTPRVLINMQQVGGLGSRPDDVLILGDIDAGVRKFAKAMGWEEELEALWEVTNPDPKAREAENAPVPSRDERLRQEVDRLTADVERTLNLTESYQQRVREKLGEPSESSFIKVDSQEQSREGGLDHVFPHLARESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V0</accession>
    <name>A0A1Q5T8V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinate repressor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8V0"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="459"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="582"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="5">
        <location>
            <begin position="721"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="761" mass="84061" checksum="934E075E5DF5AEA5" modified="2017-04-12" version="1">MSAIESSSGPLKFSSTPPPSAVEALGIRRQYNSDATILLVGFFGAGKKTLGIIASVALRRRFVDFDAVFNQEHNSSPQEFIARHGLARYRELELQISKDILTKHEKGCVIVGLGGTASPSQRALLTECAQRHPVIYVRRDENDLQQLSGTSSDKFSRIFDVVNAFFESCTNFDFFNNTQTESRGGPIPPAYLKLKETERVFVAFLHRIFGRDHRQVFSIDPFSKSHTYALQVPVTYLDRPEYDLESLESGADAITLLVRPNDINTSRSTERLARHIALLRKHSRVPIIVDLSAPHSTHSTFDYHKTLATILRLAPDALTCCLECDSGLVSKLNSSKGYTKIIGTVHEPSPIGSQHRALTPSTLTALGGALECDAIRVTGEAISPDQNYTCLSFVHDMEMTLKIPIIAYNMGPMGRASVCLSQTLSPVVPQSSKETGITVREAESALTACFLQSKKAFTIFGQSVKYSLSAAMHNTAYAACGLPHVYAILQSENLSDIHRLLEDKNHGGVTISLPYKTAILPFLDEVTSDAKDINAVNTVVLEHTQLPNGERVTVRRGYNTDYIGIRDCIHKHLSPANAVRDGTTALIIGAGGMAHAAIYACYELGVRRMCIYNRSVENAKKLADYYHQWAQSKGGVNLQLDVLCSPEDPWPSDCRLPTIVTSCIPPYELGSERPIELLLSEQWLASRTGGVYLEVGYGPSRTRLMEQFLPRASKGWVVVDGLMVLVEQGIAQYEIFTKRPAPVHVMRRAIKEQSIRHGFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAX7</accession>
    <name>A0A1Q5TAX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAX7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13108" checksum="30297EC6F477D8D6" modified="2017-04-12" version="1">MEVSDDEHLESENDSSQQGSSKSADSGDALHESSNNLEVQDLASKSNQTSETDITKICRVIEAISNQLRGVEVGMQALQNKQAKLETNMDQGLAAGQDAEMSDTSDASFKPDEEIEQSEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB38</accession>
    <name>A0A1Q5TB38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="894"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO97423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="925" mass="104965" checksum="59DE4FAB1CED6740" modified="2017-04-12" version="1">MAYNRVDPFGDEHRSPMDPHHVNSFNNRTPSPGRPLESYQLHDNPYGQQSHLPMPSSDRLAEQPTYSVENVHNSYGHHEAYEGRTGAQPYGYHQDYTVDPEAHHDAYYTQPYEPALTPHDDYDLGQYPEGGHTPFDDNAPMLQADNPFGPDPYDAQYQDEPRPTPSPAPIKRWKTVKEVQLFNGNLVLDCPIAPKLLSQVPHAEPPGRDEFTHMRYSAATCDPADFFEERFTLRQKLFAKPRHTELFIVVTMYNEDDFLFARTMSGVFKNIDHMCSRTSSKTWGKDAWKKIVVCVISDGRAKINPRTRAVLAGLGVYQDGIAKQQVNGKDVTAHIYEYTTQVGLEVKGTQVHLKPRSGPPVQMIFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLLDAGTKPGRDSIYLLWKAFDVEPMCGGACGEIKVMLSHGKKLLNPLVAGQNFEYKLSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGQGPLERYFLGEKMHGANAGIFTANMYLAEDRILCFEIVSKRKCRWLLQYVKSSTGETDVPDRMAEFILQRRRWLNGSFFAAVYAITHFYQIFRSDHSFLRKFMLMIEFIYQTIAMIFAWFGIGNFFLVFHILTSYLGSDELLGTAGKILGIVFEWLYLATLVTCFVLALGNRPGGSNKFYMTMVYFWIFIMLYLSFAAVFVTVKSIQTEVASNSFSVSELFTNKTFFSIIVSLGSTYVMWFVASFIFMDPWHMFTSFIQYILLTPTYINVLNIYAFCNTHDITWGTKGDDKAEKLPSATLKPGGKVDVNIPQDDGDLNAQYEAELAKFATKAPKEVSNISEEERQADYYKGFRSAVVLAWVFCNFALGAVVLSAAGLETFDNTSTTSSTNQDATQTERSLIYMEVVLWSVAGLSMFKFLGAMWFLVVRMVICLLWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB47</accession>
    <name>A0A1Q5TB47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB47"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="27571" checksum="768124A798E3A5AE" modified="2017-04-12" version="1">MAENNQDQTFVVITGDPQKGHGARLSQARSHLAKQYHGKKRSQNTNANTRQDNTRQAQQVIALRRALQAVPPGIRLLLEPPPTPPSVPGVKRMQRFYEDYQYPPAIVRPHMLIEQSVHSQQSNDDDPRIPVLDQARYLLNLSNSVSDIDPSLAQGVTHLKYLLHRTDMDVFWGPLPGAMIWCLVIGARLAQPGSARKWFMMQIQRTCCAMAVETCERVLRCLRTVLVGLDGAQISRPEVSLMSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB68</accession>
    <name>A0A1Q5TB68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="18244" checksum="781A0CC137AE23E7" modified="2017-04-12" version="1">MPQAARWAGTPSIKGRSESTRMALLTFSLVGLQFTWGTEMTYCTPYLLQLGLTKSKTSLVWIAGPLSGLIIQPLIGVIADRSRSKWGRRRPFMVFGSFVVAFCLIVLGWTAEIVAMFVKEPEKVGAAHYNSRRKIQACCRSLIVDTLPIPLQQAGSAWGTLAPIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBM1</accession>
    <name>A0A1Q5TBM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="2">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBM1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBM1"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000021">
        <property type="entry name" value="Acetyl-CoA carboxylase carboxyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF46">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="6">
        <location>
            <begin position="64"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="7">
        <location>
            <begin position="222"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="475" mass="52020" checksum="35713AF62B3864A3" modified="2017-04-12" version="1">MATESSYPTLSAKLDLRGEQFRANKESWIPVLEKFEDALKQVSAEGNDVSLRRHQTRGQLLLLKVNRMMEVAFENDLPLISLVQSAGVFLPQQFRVFHKGGQLFHDLAVRTQHGKPSCAIVFGSSTAGGAYHPALSDYTIFVENQAQAFLGGPPLVKMATGEVIGAEELGGAKVHAVTTGLADQIATDEFDAIRMAREWVASLQMRTPPRLDMIEPIVPRYPIEDLLSLVNPDIRKPFDMNEVLLRIVDDSRLSVFKPKYGPNIVTAWAHIMGFPVGIVANQISVINPNEAGKAAQFIRMCNQQNTPIIFLHNVTGFMVGAKAEHAGIIKAGAQLVSAVSCSTVPHISIILGASYGAGNYAMCGRSYKPRFLFTWPTGRCSVMGPDQLSGVMEQVQIASAKSKGQILSPEKLQKQVKGFRDRVERDAECYSTSSMLIDDGIIDPRDTRDVLGMCLETVTLQGVKGTETHNLLARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBS1</accession>
    <name>A0A1Q5TBS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Plasma membrane ATPase</fullName>
            <ecNumber evidence="11">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBS1"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000042">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="350"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="856"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="13">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO97678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="949" mass="102451" checksum="860DFEC09CA502AF" modified="2017-04-12" version="1">MTSKDVSKPSTIRLWDLSDARNLALGSHPPGPHSDQEDKDAPATAAIPDSPSRTTSSGDKLDQSASRETAEDIDLLIAELEEEDGNEPEPKVITISIAQDTGYHAGLLETDLNLGLNDADIIAARRKYGRNRLKQEHQNNLLKFLKLFVGPVQFVMEASALLAAGMRDWIDFGVICALLILNAVVGFTQEYHAGNIVDSLKQTLALKATVTRNGHVLEIEAEEVVPGDVIHLEDGTIIPADGVLVSEGAHLQVDQSSLTGESLAVDKHQDDICFTSSTVKRGTARMIATAIGDNTSVGRAAALVNLADSGTGHFTMVLNGISMILLGLVCLALFVVWVSSFYRSQPILDILQFTLAITVVGVPVGLPAVVTTTMAVGASYLAKRQAVVQKLSAIESLAGVEILCSDKTGTLTRNKLALGDPYTTPNVTKNDIMMTSCLAASHKKKGLDAIDRVFLKALKAYPEVKATIGSYEVIEFHPFDPVSKKVTAVVKSPQGERIICVKGAPLPVLRTVKEDHPIAEDVETAYLEKVTEFAGRGFRALGVARKIGDQPWQILGIVPCLDPPRHDTAKTIAEAQRLGLSIKMLTGDAVGIARETARQLGLGSNIYNAERLGVTGAGEMPGSEVNDFVEAADGFAEVFPEHKYSVVEILQKRGHLVAMTGDGVNDAASLKKADTGIAVEGASDAARSAADIVFMAPGLSAIIDAIKLSRQIFHRMYSYVIYRIALSLHLMIFFGLWICIKAEVMDIRHVVLLAIFADIATLAIAYDNAPFSISPVKWNQPKLWGIAIILGLILAAGSWVAFGTILLHGEAGGLVQNFGDRDGVLFVEVTLTQNWLILVTRHIDGPFWKNLPSLQLLAAVLAVDVTGTLMVIFGVFGHQPTSVVALIRVWVFSVGVIIILGIVYSFLQNSQAFDDLMHGRSPRARTRERSWEDFLLSLQRVSTQHEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCT5</accession>
    <name>A0A1Q5TCT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCT5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="13676" checksum="87E16CD428726662" modified="2017-04-12" version="1">MKYYYPVDSAFGLSFILFLDLRIFDRGDLADNDDCMNKLQGTYKLSSQTRFLRETARAKQAKYLPLTVSSTSALGVFKQQMPNFGGLRLLSNAETHCSFQGFIPKLWIQGPSHENQRPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDB8</accession>
    <name>A0A1Q5TDB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_9313</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TDB8"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="634"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="845"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="14">
        <location>
            <begin position="1246"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="144"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="290"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1146"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1333"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1163"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1412"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO98215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1474" mass="165029" checksum="9493D2CC6547312D" modified="2017-04-12" version="1">MTKNNLAVHLKWLLKQGPSLYPTLSADNPPIDPGSRVSQQPTSPSDETELLDQLLEDAEDVKDENMARLMLAPSSESKPRMLSRGDTRPPSSPTIKKPSSSRSVVQESFLEPPQSSLKSTRPKATPIRSNRKLATCPFDEIESIDLTGDPDRFLPTSSNLDLAGPRRLWAEDSTSRQTPVEKRGKKRKSDEYTSDLLSPSKHTNKFRSPLKSSGSSTSKDVIPEIPSRVSRGDRANGVKHGKLSSPVLPRSSRKREIAIADSDEEDPFGDSWFHDDDIIIDANTGLYPKLPAVSPSDDGNDVPEPIVGQQSQSVLSNRPLSPARKNKGSKEKPPKPQPPSSGPTVSVPSSQAKDENIFKFTALPSEVFEKAILRLQQTLQKNAEIVYEQAMAGRPAPELIAANKGLVSQIQAIESLQRQKHSHSDCLARKENLKRDVMRVISQGLDPTTLPELSQSRVVEAELEKVESKIRELIPRAKIFDFAAELGEDLQDAPAHISRTREQSERVTSREPPPVYQRPKQSVASPRKEIPFVSRNMASPTLDFDEFDWSDSDDEMLEVAGSFDNEPQVPVREPTQTRKVFAETSGNSSRMPPPKKSPGRSNFWSNHPWSQEVKTVLKERFHLRGFRPNQLEAIDETLAGKDTFVLMPTGGGKSLCYQLPSIVTGGRTHGVTIVVSPLLSLMEDQVDHLRKLNIKAFLMNGESDKTERSWILGQLSNGDAEGLELLYITPEMISKNQTLVRALENLHRRGKLARLVIDEAHCVSQWGHDFRPDYKELGEVRAKLPGVPVMALTATATENVKVDVIHNLKMTGCEVFLQSFNRPNLTYEVRPKGKNNEVLASIAETIKKSYKNQCGIVYCLSRKTCEKVAEDLRDTYRLRAAHYHAGMKSDDKTKVQKEWQAGKWHIIVATIAFGMGIDKPDVRFVMHHSIPKSLEGYYQETGRAGRDGKRSGCYLYYGYKDAATLKRMIDDGDGSYEQKVRQKHMLRNVVQFCENRSDCRRVQVLAYFNEYFRREDCGNSCDNCKSDLVFEVHDFSQHAAWIINIVRWFQNQTNEKGDKGEKVTVLYCVDILRGDLKRAKSPSHKTLPWYGKGSDLDRGEAERLFYRLLGEDALAEDNVINGKDFAVQYLKLGRRATEFETGQRQLNLQVRVSPNGKGKAATKPTQKSKSGTQSYPQSTMVSSPIQSAHDRRQARSQQRSKRVNDPSADDESDGFEPLRVAGRSRNENGHAVGPPITIDQKMERLDHLHRAVVEDFEVTAKRYLQEIVVEKGLRSQPFPDHILRDMAITFPKNISELSAIPGIDSDKVKRYGRQILRLVDNARRRYHELKDEAESNGIVPDPNHHNVINLSSSDEYSDDDLFVDQNTTLDLDYPMENPPDNITSRYFPPPPSPGFDPGDDFERGPAASSSKGGKRAYTKRPRRKNGGSTGGTWKGKGARSRAKSSGDRAPSRSSAAPRKNATKASKSTIGMMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDP0</accession>
    <name>A0A1Q5TDP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="204" mass="23067" checksum="58380A31F1B158EA" modified="2017-04-12" version="1">MIRLYDDTFKNSNPNCIVIWHSVCISMTADIDILSRAAGRDGAESMVEARKALAYWVQTASARRAYIQAAQTFRILSHRKPADGTAFQPVRTLSRLPWFLGYTFNDEKPFDLANTSMDWKVVGDEGFSTSESSIRDNTEGVESDAVRCIRFGGPIVIDRKIYDSGARHAQRIILEFASLLDEVGTHWMADYARLLYMTHDTMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEC5</accession>
    <name>A0A1Q5TEC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEC5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="5">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="99" mass="10845" checksum="5592A4BB111E4C24" modified="2017-04-12" version="1">MSAQRTNISNELIWQITRNQNAYLVRRNTGGGSQFSRDPLNLVNKHSLKYAGFANNKAVGVQATEDGSIAVTTKKPSNPQQPAQNQVTVTYGPKTATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEE6</accession>
    <name>A0A1Q5TEE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 11">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000671">
        <property type="protein sequence ID" value="OKO98587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TEE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF24">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="732"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1219"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1115"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1239"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1732" mass="194508" checksum="85434DA1D2A455DD" modified="2017-04-12" version="1" fragment="single">MSLQHDSSFAKSPAARVDYSNFIADPSTAAGGAVTQITDVPESYTLHAIDDKLTNANDFDTWLDDVTRILQQKNLHRLIDAQIERPPTTSPHAARWFRVSKDIQSWLYQSVSKEINRLMLSRRTPTQFADEYIGALKETLNKTGYHAAIKDCVAWWETRRSQFTSGIEFLTAFRDRYAKTAQKMVTPPFLIAGVLLHEIRGDIPTMIVARHTNNDRIYANPEDFKDVDLHKLFNELENELESAELHSITAASIDKASSNNPNPNASNSNAGNLGRFNNSEYWPLKNTPPRGKGANIGKWIEEWKNSEPQTTPNGCCTFCGRLHMVRVCAHISIEHRAPDWKPVKGIWVSYPWKHRDNMNGPKPDNWNLIYDNRIRKDGTSKPYPNMSAANTTPAAAVPPLPTPMAPKPSTTASTQPSTTLPQLPLISTTLPKPTDQNPSAAAIYEDDLYPQYLDTTGFASMTLEESYISTNDCLATTMIDDDDWFDDDQISQLEDYDFEQGRIPQTVMYTGGVDQNMPIPLSMATIARSRGEWIVDSGASRTICVDGDAIMHFEPYKDNAYRCQTSEGRTLVAKGKAIARINLVFPDRVVNLDVRCEYVPEGPFNLLSTTRTYYEHGMGWKDWKNTFVNPLDESIIMAYAYRKRGVPFLHTTSIRPSQSTEALVPSSVSYAYSLATITPELAHFRLGHVGQPTARINHHRIGDQVHGDESFDCEPCRRAKSRKIVSHTPQKRASKPWHFIHIDIQPCKPTGINGTNYMVVICDDATRMRWALPIKTRDASSQALIKWATIIFNVTGYWPIEVRIDGDLAFRAWIVWIEGKGTLISPSAPYTHEQNGVAEFTGHIIMQSARTLMISAPEAPAFLWPEAAIASTYILNRIRRPNQQESPIETWNRELNLRQSGPIDLGFLRVWYSKAYVHIPKERRVQGNKMAPRAWIGYLVGYEGENGHIYRIYDPSKKQVVSRRDVAFWEEPLPLRKIPKPIEPDEIAQEAPKLPTQMTIHGEKVIEPIPRTRTPPALAQVRSQEPPINPQRRRKQPRMQLTAPIAPSAPNRPNLTVSSSHEIAHTTPIAARISNPTIARSNTQTIASTTPVAPRIAPVVERQLPILPHLPNPPTSQHQPFQQNQNTTSISFQPHWPGIQRATIPSPRQIEPHTVRGLQPRTPMKRLFGDLQDPDTPLPTVEGPVENPPDEYLHEQHLQHHQHMPTPTATESIAETITSSNAEPLPESNRSTLERETSSVDPISTISTNANPPIAPNRRTRKSSSLEPTRRSQRAPQPRQLTPGMTTYPAKGAMVLREDDGSYYTGNIEDDDVIGPGLICTATERIRSGMVEIPHTHLQAMKTPYAEYWLQAEKVQLGKIAAANTMTLVPRPPKGTSILPGKWVYDLKQDSEGYILEFRARWVVCGNRQTPGVDFQPDERYAPVASDAAAKLFLSMAAISGYRVWQWDVVAAYLNAALDNRAIFMKQPTGHEYYSPDGTDFVCLLNQALYGLRQAGYLWHEVCTKDLDELGLEPLESEPCIYTNPDFSVYILIYVDDMLATGEEAEVAAIRQGLASKRKLKELPFSRFLGCDITREGSVILANQQAYLTHLIRDEGLQNTNPASIPMNPSWRTPIEKPDPADCVDKLKYAQKMGKVGWLSIKMRPDIASAVSKLQRRSGSPREADMLAYRDLLQYLAGTIDLGIPFGRDPTKGLEGYVDSSYGDAEDGKSTEAYIWFFAGAPISWSSNRQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEH6</accession>
    <name>A0A1Q5TEH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEH6"/>
    <dbReference type="OrthoDB" id="3921745at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="33738" checksum="7F0C37378B37A2B3" modified="2017-04-12" version="1">METRTETYTRHQLPSARQGRMKIDSLLNPSADGGPDEHSSTTGSPYSQHATMSSSSHNNGYAHSPGYPPSPNQYWYSSRYQGYHDTSPGAASTATTHTSSGSGSGSGSGSNSHHHHHHHQSQQHSSSNGQHHHHHMFLSYRPTNGSTRSSPDPYHPRERYDSVSSSSSNNGDRRRPPRPKYEEEEMYFIWYHRVDLCQEWKEVRESFNRQFPSRQRRGFQGIQCKFYRFIKEKKCPTLREQRRMRDGEFLREGASMGADSGAPRFGVREWANVWYPWMREGEEISPRQSRMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFJ8</accession>
    <name>A0A1Q5TFJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitosis protein dim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFJ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="199" mass="23141" checksum="ACC712B7905E8859" modified="2017-04-12" version="1">MGSIVLPHLRSAWHVDQAILSEEERLVVIRFGRDHDPDCIRQDEVLYKIAERVKNFAVIYLCDIDEVPDFNSMYELYDTMTIMFFYRNKHMMCDFGTGNNNKLNWVLEDKQELIDIIETIYKGAKKGRGLVVSPKGKISRLLQSRGWHALTSVQIIRRDTDTKCDLARPTDGDTDKAWWRPRLFMNITTIIAGKEVNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG44</accession>
    <name>A0A1Q5TG44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG44"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="272" mass="29611" checksum="FD6C2AE38A35CF48" modified="2017-04-12" version="1">MAATPARTSTLLSNIAAVTTRITTATAHSQFPTKPVRLVAVSKLKPASDVLALHKSPVTQYHFGENYLQELLEKSRLLPPTIKWHFIGGLQSNKCVTLARDVRGLWAVESVDTEKKATLLDKGRGERKPDAEELEAEAADSDTDSRLRIYVQVNTSGEENKAGIEPAAAPALARHIREKCPRLKLQGVMTIGAIARSRATTPENENEDFVCLRETRDRIISELGLAGADAELELSMGMSQDFEGAIALGSDQVRVGTTIFGDRPPKSEARVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG92</accession>
    <name>A0A1Q5TG92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG92"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="295" mass="32655" checksum="A2FA82B3B6BB70C4" modified="2017-04-12" version="1">MSSSQPPSSVDSTDTPYRYAAYAQRVRTILLSAHRYVAYTSDIGESFRPVAHPWLVRSAYGISWTYLVGDVGHEGYKAYLRNRRALAPPGDAHKDATSEQILVGMATGNISMPLSSEGRAKEKDSLTPWPTTEISLAEDYRMVMVKRAVFQSIASMGLPAFTIHSVVKYSGRAVKGVKSTLLRTWFPIGLGLSVVPFLPYIFDHPVEEAVDWAFGTALRLYGGEDAVRPLPNHAMLSKAAAEENGSVTTAAQLSWEEYKNEREKARELRLEQSGSKSLSSWFGGWTSESEKPKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THD4</accession>
    <name>A0A1Q5THD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THD4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="698" mass="80712" checksum="17D229C8714A2AA8" modified="2017-04-12" version="1">MNRITTIPVPATIQRTGSPIWRFFKEQESEIVNLAAQCQLKQQQREPLDVVLPDDEAECDSDDDDDLSTVFPAQLTTDGTKQIKTEFLDRLAEIQDHVHVVRELLANYYHARLQHHAEKLKKLVKHVDPHIKAVLLWCCGKFLSKTVSPLEFVEFMGSLSQHKEYAPQPNWVNDKLGPKQIQRINLEMAFICRPEIAANTFFAVARDVPSFQKIHIQLLIGYKPRKIPQKLTTTVKSSTTNKEKNLRAQPAEPRWVHAEIRMITYLLNRENNNQLFTYLGISKKMCFLCGHVVRKLGRPMDEAHYLVQACQSGDQLPAEENVLKAFGFFHFGSGRERFQLFQTYRKLILHGVTVEEIREAWQKNMLKEFIVSRCAQLPPSLLGSERVWVGHTEGFARDSEQGLGSIPKSMKMHLSAEDRRLAPSELEPEAKRSAFFFYVQILNQYMPGADEDNWVSLGFCTARNQDEIQWLSHLYALLIERCQFEEFWKAMDESTIVELFKKYKLDPGIANLHNFETLMRDIGKWRQSVWELKKFTQTTEVWPTRSVEVDYGFKNCQNARERLGLRHAYADYFARGEDEMNLHQACIDGWLAQFLTAKLGPLQIPDEVFANDYPGKRCSYNGMTVKSTIVCPESMYHIVLERQKAEGDRELIITVPDEEDEIIKEYIRTQAARTTGRMRVETQTTSHGVEIASMSVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI24</accession>
    <name>A0A1Q5TI24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI24"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI24"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27305" checksum="748F5DF5477802C0" modified="2017-04-12" version="1">MTGRQNEYFIPGDGISREVIQADICRYLGNDALEMIADLKADSARWEADVSRRADLGYPRGSYIQDVSPSHAPNTVSANYATSAIHEVRQQQGPSPTTYSAAPAQPYMDPYSQSPYSGSQTAPYPNPSYTSTHSPYGQGQAPYPPPQVTYSGAQQPVVTTADIHPSSYTYSATGPAYGGYEGAPRNAPRYPGPGYDADPDYSPVTSGIAYPASTSAADSRMSGSMEPRYTPEYERSRPQPTRERDPHRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIH6</accession>
    <name>A0A1Q5TIH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIH6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="10673" checksum="293AC22FDD72D856" modified="2017-04-12" version="1">MTTIHWPGGIPREIKPHPETDLSQDELEEEVKGWLLFVQENWVPRDRANISDDDKEYELRQRRALVQNWASESQDFRDVRPIHYLQAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJ20</accession>
    <name>A0A1Q5TJ20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000648">
        <property type="protein sequence ID" value="OKP00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJ20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJ20"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="470" mass="51868" checksum="8DFA222D748410DB" modified="2017-04-12" version="1">MPPPTLSSKLTSIQGIRLAGSASAWNIDIHYPADSPRGIIQSITPHEATTPGDDSVPTPLVLPALTHPHIHLDKAFVHSASQYAHLLPSTGTFQEALSFTTEAKQQFTVPDVLQRGEWLLAESVSAGVTAMRAFVEVDHTVKLVCLEAATKLQDQWKDACEIQIVCFAQDPIFSTQHGEENMELLEQALARYPQIDVIGTTPYVESTIEAAKRNIDWAVDRALELNKHLDFHLDYNLDSGKEALVWYVLQSLQHRGWTSSSTTKRVMLGHCTRHTLFTDEEWCRISHIIHENDLPVSFVGLPTSDLYMAASPDQKTSHDRPRGTLRVPEMIRKHDLDAVMGVNNVGNAFTPWGPPDPLFLACLGVGIYQAGTQDDARLLYECVSTRARAAIGLSSSRSSIGLKEGDSPDFLLFHRQDLTGCRVARPCGTVAEVVWDPPATVNRDVVVGGQLKRSGFPCSRGDLVYKFSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKM5</accession>
    <name>A0A1Q5TKM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotic sister chromatid recombination protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKM5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012208742" evidence="1">
        <location>
            <begin position="22"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="39997" checksum="51D317FC14202268" modified="2017-04-12" version="1">MKLNLATGLVCLLATTEAVAASSWWSKAVYNKWHETELERWLSDHDIPYPTPADRRDLENLVKSNWENRVQKPLGNAADRVTDEFHEAKEWVFDTWSDSQLKAFLDRHGIPAPQPRKHDLLLKTARENYESIAKKAGETAAYPGNWLYENWSESDLKDWLDERGWPAPQPTTRDKLVASVRRNSRLASLQAQSISASAAASAEAAQASLSEELFNAWSDSRLKEFLDEHNVKVPQGSRRNELIALARKHRAYLVAQASSASAAASEAFGAATTKAGNEYARATDDVKMKMEDQFDAAIKTWSDSRLKAFLDARGVPVPQYSKRDELVAKVRANAHRAAGGWNEYNFDTWDKEHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLC3</accession>
    <name>A0A1Q5TLC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_7605</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLC3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLC3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="310"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="526"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="759"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="762"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP01024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="793" mass="89676" checksum="26C582FC4BFBF4F4" modified="2017-04-12" version="1" fragment="single">FSGLRTFVTQMLKLADEDVVNKFSLESFSKRTQSQKTDPRFGYKDLSYLPLKRDHYNRPLWIEPVKGTITLESFSPLAPQAQDFLTTIAEPLSRPTHLHEYRLTGHSLYAAVSVGLKPQDIVEFLDRLSKTPLPESISQFIIEFTKSYGKIKMVLYHNRYYVETVEPEMLQMLLKDEVIGPQRISNEEGIIERAAPKMGALVIPGTKDAAGVRETAGQAKASGTSRTETQGERQDYGINDVGDEASEALTYSFEIPPTGVEIVKARCQAIGCPALEEYDFQGDTINPNLDMDLKPTARIRPYQEMSLSKMFGNGRAKSGIIVLPCGAGKTLVGITAAATIKKGTIVLCTSSMSVVQWRNEFLRWTTIDPGDIAIFTSDHKEKFKRSTGIIVSTYSMVSQTRARSYDAKKMMDWLQSREWGMMILDEVHVVPASMFRKVTSAIAAQTKLGLTATLLREDDKIKDLNFLIGPKLYEANWMELAAQGHIAKVQCAEVWCPMTTEFYSEYLRASSRKQALLYIMNPRKFQACQYLIDFHEKRGDKIIVFSDNVYALEKYARKLNKAFIYGGTGQNERLRILENFQHNEQVNTIFLSKIGDTSLDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTSEMTYSSKRQAFLVDQGYAFKVITHLQGIDEYDGLHYATPSERRELLTEVMLQNEASADVEQVTDDLFSMRSGGRNAAAKKAKAKRSAATLSGLAGGDDMAYIEYNKSRNKQLKDKAAQHPLFKKMERDRLRRKKERETAKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM49</accession>
    <name>A0A1Q5TM49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM49"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM49"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013157779" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="49566" checksum="881B2253475FA985" modified="2017-04-12" version="1">MRWSSLALALLAGVVTAADTTTSESSTTSKSDSSTSIDLSSASTVTNPSTVALPSGNYITYSTTITLDNGNSSVLVSTTAAPNATTTSGNQTMTTTSDSLTVLIGGGHTTTLGNGTMNATATASSTSTQTPVVNTRPCNNYAEFCARNYSNITMVAAHNSPFVRKGNAAANQELDVTAQLDDGIRMLQFQTHYQNGTMMLCHTSCDILNVGTLEAYLTTVAQWMRKNPYDVVTILIGNYDYVSPQNFTDPIKNSGLYDLAYTPPKIPMGLDDWPTLSEMILTGKRAVFFMDYQANQTAVPWLMDEFSQIWETPFSPTDASFPCTEQRPPNLSEKDAKSRMYMANHNLNLELNLGSFSMLIPNTATINQTNAVNGNGSLGWMANNCTRDWNRPPNFLLVDYYNYGNFNGSVFEVAAEMNNVTYNRTCCGQESAAVPGMSTASFSTMLAIAAGVQIFLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMK6</accession>
    <name>A0A1Q5TMK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein arginine N-methyltransferase SFM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMK6"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="23626" checksum="475592D7815FF2AF" modified="2017-04-12" version="1">MTDQKTQQPKAFVVEHLDPELGPWSALEYAAIARESHANGARFLLSSVPAELQMPAELAATKGLEVEQRGVEEIFADRKDKVCLLDPSAKTELSPEDGDVFEVFLFGGILGDDPPRDRTSELRKKGYNGRRLGPKQMTTDTAVRVTRMVVHERVPLEKISYVDYPEILINEHERTEMPFRYVVDAKGEPIMPDGMVDLIKNDADKGVGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TPP0</accession>
    <name>A0A1Q5TPP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000627">
        <property type="protein sequence ID" value="OKP02203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TPP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11560" checksum="5DF78B8BD3BA0E46" modified="2017-04-12" version="1">MADSYAEQEARISRALEDYTSGKNQNLSALTREYRVNYQRLRRRLIGLPSKIGNQNRLRLLTRAQEDAIIRIIDSLRRYNIKLNGKDIEDLANLLLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ81</accession>
    <name>A0A1Q5TQ81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ81"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF5">
        <property type="entry name" value="BYS1 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G04533)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180227" description="Bys1 family protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20383" checksum="C44C8AF82B50F325" modified="2017-04-12" version="1">MKLSSTIHLLCLTGFTLSQPTVLKKTDEIPYGSFPSPASSSVNLSPTATPTPSASLDARLGRAIIVNQCNLPVYIWSVGTVVRDPATLLPGNRYGETFRQDHKAGGIAIKISTEENGLYQSAPLTVFAYNINDQNVWYDLSDVFGDPFKGYPVVLSPAEPAIDWANGIPPSGSQVRVRDVSEDLVLTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQK9</accession>
    <name>A0A1Q5TQK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TQK9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000652">
        <property type="entry name" value="Related to VPS15-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="10">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1465"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="841"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="842"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="908"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1354"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP02501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1590" mass="176643" checksum="D633F0D3D28E790D" modified="2017-04-12" version="1">MGQGYSLTTLSAGSAGIDVPELSDLVYEKSMGGGRFMKSIRARQQNGLVFVKVIMKPYPTMQLGPYVKAIMKDIEKKWIAFQLLCALRDSHSLDVFHGDIKTENVLVTSWNWLYLSDYSSSFKPTFLPEDNPADFSFYFDISGRRTCYLAPERFLVAGEEPGNRHVNWAMDIFSAGCVIAELFLESPIFTLSQIYKYRKGEYSPEHSQLVKIEDLEIRELILHMIQLEPESRYSAEEYLNFWKNKAFPEYFYSFLHQYMSLMTDPSSGRTKVDAESNNRGETDDRIERVCLDFDKISYFLGVPPRASAGGPSATNPAPRLTGSTLPVKLDLPDGDGDGNQITASSPQLQSDEGVLIFLGLVASNLRTTSKASARIKACDVLLAFAEKLSDEAKLDRVLPYVMILLADRTDSVKVAAIRTLTQLLEMVHVVTPVNAYLFPEYIFPRLQPFIISSKHNPSPMVRAAYASCIASLAQSSLRFLDMIQALRSDTRLTSLIPVGFEPRWTEDATYHNLYDVARIDLLEYFEVHTKALLTDTDASVRRAFLGSVSSLCVFFGNLKANEVILSHLNTYLNDRDWILKCAFFEAVVGVAAYVGSTNLEQYILPLMIQSMTEPEEFVVEKVIRSLAAMADLGLFQRSTTWDLLHITIGFLVHPNIWIREAAVSLVVKSTKFLSVADIFSILTPLIRPYLKVKIVGFSEAELLDALKRPMSRNIYEIVFLWASKTDKGIFWKSASRDAFSLSEPGSHSSRVGRSVSPSMSSQSKNEEDEQWLSRLRNLGMTVEDEFKILALRDYICRVSLRQSRDVEAETTLPLGEIISLSQQGVTPQTVFFDKNLNEKSRNTSLERNTSRTRNPLDDPRPRTIADALLDASTTIERSPSAHRRHIRTRSQLHKEIEIPHPRSIAVESSSSSPAASSPAAAPGSRPMSPPGSDVERHTIHANRRLSSGQESSSTTPTNADTLSLRGLPVQRKSSAINLLNRNDTAKAYAETGTSAANVFGKVDAPVQRSGAPQPSALSHAYERKPTQAVVASRRYRANHSYTGDDPVVLRLLDNVFAENYPTDLFDLGPYVKELDSRQPIPKSNSQNVNKLWKPEGNLVATFGEHSGPVNRIAVPPDHSFFVTASDDSTVKIWDTIRLERNLTPRSRQTHRHSPGARVKALTFVENTYTFVSGATDGSIHAVRIDYQKVNEIARYGKLQLVREYQLPVAENGLQEYAVWMEHFRDEGQSTLLIATNTCRILALDMKTMLPVFTLENPVHHGTPTTFCCDRRHTWLLIGTTHGVLDLWDLRFRVRLKAWGLPGWGYIHRVQLHPIKSRGRWVCVSSSGIHGNEITVWDIEKFRCREVYQAAPLNSSETATPNGSAPTTHHRSSRGIATSRAHRLSARDFEAWPVDEDRPEGMLSRFATTSPAAAGLEAGPPVVGNNGSAAAPTNLAGDRMGTLAFIGGLNTPDDDKAASSNSKLGFIVSAGSDRRIRFWDLANPAGSMIVSGLDAVANGTAASKPQYETTQPGPHLSMVIEHMPRSSGDGAAAAVSKKGASPRPPRSTVISLQQQMLLKSHLDIIQDVAVLRQPYGMIVSVDRAGMVYVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TVT1</accession>
    <name>A0A1Q5TVT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_6766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the FACT complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000612">
        <property type="protein sequence ID" value="OKP04279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TVT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TVT1"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="14">
        <location>
            <begin position="7"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="15">
        <location>
            <begin position="542"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="16">
        <location>
            <begin position="815"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="936"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="938"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP04279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114890" checksum="9D5FCDC22BEC5124" modified="2017-04-12" version="1">MADKIAIDKNTFFNHLSNFYASWKADKRSGNTLFGGAGSIVILMGKTKSDESSFQKNNAMHFWLLGYEFPATLFVLTTEAIYVVTTAKKAELLEPLKGGKIPVELLVTTKDPESKTKAFEKCLEVIKGAGKKVGTLPKDTTTGPFADDWKRTFSEISKEVEEVDITPALSSAFAIKDPEELVSIRNASRACSGLMSEYFVDEMSQLLDEEKQITHKALAGKVDAKIDDSKFFNKLARLPSEFDAEQIDWAYGPVVQSGGAYDLKLTATSDGNNLKPGIILSSFGIRYKTYNSLIGRTYLVDPSKSQEANYAFLLNLHDAVMKEIRDGVVAKDLYNKALSLVRSKKPELENHLTKNIGAGIGIELRDANMILNAKNNRVLKNGMTLAITIGLTDVKDTDSKSKGNNVYSMVITDTVRVGESGPHIFTKDAGIDMDSVSFYFGDEEEPEKPIKEKKESKSSAVASRNVTRTKLRAERPTQINEGAEARRREHQKELAGKKTKEGLERFAGTTGDDNGVAQKKFKRFESYKRDNQLPPKVKDLTVYVDHKAATVIVPIMGRPVPFHINTIKNASKSDEGEYAYLRINFLSPGQGVGRKDDQPFEDPSAHFVRNLTLRSKNNDRMAQVAQDITELRKTALRREQEKKELEDVVEQDKLVEIRNRRPVKLPDVYLRPPLDGKRVPGEVEIHQNGLRYLSPFRSEHVDVLFSNVKHLFFQPCAHELIVLIHVHLKTPIMIGKRKTRDVQFYREATEMQFDETGNRRRKHRYGDEEEFEAEQEERRRRAALDREFKAFAEKIADAGKDEGVDVDIPFREIGFTGVPNRSNVLIQPTTDALVQLTEPPFMVITLNEIEIAHLERVQFGLKNFDLVFVFKDFHRAPVHVNTIPVEALEGVKDWLDSVDIAYTEGPLNLNWTTIMKTVVSDPYGFFADGGWSFLAAESDSEGSDEEEESAFELSDSELAADESSEEDSEYDEDASADGSEAEFSGDEESGEDWDELEKKAKRQDKETRMDDDDRGTKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXM5</accession>
    <name>A0A1Q5TXM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXM5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="133" mass="15441" checksum="C62B7361507CDF69" modified="2017-04-12" version="1">MPKFADFDEVRMAKAFAAPISQKKLNIAKIAHEFDVNCATFASRIKKAKSPVNPKESRKYSLRVYQERALIKWIEEMRGWNLPSAPAIIQSWANRAIARSAQPDRQISKMWAYRFIERLPDHRTLAPVKQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXQ2</accession>
    <name>A0A1Q5TXQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP05001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXQ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXQ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="11889" checksum="671713F1D6664BA5" modified="2017-04-12" version="1">MPLQEGLNGCNSLNETLWSSSSGFENIQNDLDYLVLQKKYASDQRYWIAPVHGTPSSVDSSGCVKKASANERLPVLCTQTAPYSTADEKNTNAIWQVTVNSNKQYLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U076</accession>
    <name>A0A1Q5U076_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U076"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U076"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="11145" checksum="9381E5577F02916F" modified="2017-04-12" version="1">MVERAYLRLDDLEAFNPAFPLLIIGCEARTDERRMRILEHIERATHTSSLRSLHGLPNILQQIWVQDDLAVDYELDYLNRLDAVITSYRIMPSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0P3</accession>
    <name>A0A1Q5U0P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0P3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0P3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF86">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G07000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="210" mass="23232" checksum="93DC58B324A8CE59" modified="2017-04-12" version="1">MLEFRYLVHFENDNGDQFFANGDSPDPVIGGQIAAYRSFDDLREGKGAVNTAIAKLKVPANPPVWTKPAAALASPNEEIVMNRFCASNLPDWELPEQSGGQFFYAKAFDKFAPLGPVLVHPSLWHEVKKIARLVTRINGKVKQNCHLDTDMICEPARVLSWMSQGTPAGVGAFQSPREFLKDNDVVEVEVTGLGTLRNVIRFGEGQDSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U175</accession>
    <name>A0A1Q5U175_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10016</name>
        <name evidence="3" type="ORF">PENSUB_10368</name>
        <name evidence="2" type="ORF">PENSUB_10391</name>
        <name evidence="17" type="ORF">PENSUB_2221</name>
        <name evidence="16" type="ORF">PENSUB_344</name>
        <name evidence="9" type="ORF">PENSUB_3598</name>
        <name evidence="8" type="ORF">PENSUB_5262</name>
        <name evidence="15" type="ORF">PENSUB_538</name>
        <name evidence="14" type="ORF">PENSUB_563</name>
        <name evidence="7" type="ORF">PENSUB_5752</name>
        <name evidence="13" type="ORF">PENSUB_582</name>
        <name evidence="12" type="ORF">PENSUB_604</name>
        <name evidence="6" type="ORF">PENSUB_6233</name>
        <name evidence="11" type="ORF">PENSUB_889</name>
        <name evidence="10" type="ORF">PENSUB_925</name>
        <name evidence="5" type="ORF">PENSUB_9668</name>
    </gene>
    <organism evidence="6 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000696">
        <property type="protein sequence ID" value="OKO96965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000571">
        <property type="protein sequence ID" value="OKP08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U175"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP14075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="76" mass="8690" checksum="5EE097309A2C03AB" modified="2017-04-12" version="1" fragment="single">MPKYSNFDEDRLQKACKAVLHQKKPNIAKTAREFSVSRTTLADRVKKARSPFSTTESRKNALTSHQEKALTAWIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1F9</accession>
    <name>A0A1Q5U1F9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1F9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1F9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="28804" checksum="3BC08D48B85C5CC9" modified="2017-04-12" version="1">MDRYPTASAMQANGPMGQYPVPQPMRAPAPARSLPDPGELAARIEEAKNSAKLLTQFVQTTPQAELEENDLIKEFIDRCRTSSRYLQGYIHSTNPAPDEETLLTLIETNDEISVALSHQQRAMLKARKARGSSTPTSNINSPASPASEVVASGGIGARPAAAAAVATSVSTEQTPGVEPTKRESRSPEEQSAPVVELPSTFTVNRSTALRSNPEEYDYKSSDFEVQNPFADENAASDSDAERHPPHATTTATSTDGRVRVQPSEQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1J2</accession>
    <name>A0A1Q5U1J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1J2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1J2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27145" checksum="82BF1A68E7A0B0B9" modified="2017-04-12" version="1">MARIFITGSSDGIGQAAAKLLTEQGHKVVLHARNAERAASTQEAVPKAEAVLVGDLRSISETKKLAQEANTLGNGTFDAIIHNAGIGYGSTSSREITADKISAVFAVNTLAPYILTCQMKKPTSRLLYMSSDSHYGGDESLRNVTQSHSYSDSKLHDVMLANAFARRWGDDIQVVSMHPGWVRTKMGGSMAPGGMDEPANALAEWAIGQGRLAGLPSGTFFTTRGAKSAHPGAGNVSKQEELLKICKEVSGVAVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1T5</accession>
    <name>A0A1Q5U1T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nephrocystin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1T5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1T5"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="836"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP06442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="927" mass="104339" checksum="B9149BA1207A3E6D" modified="2017-04-12" version="1">MAEALAIIGLASAIVQFIDFGTRVLRQLHRLNDEVSSGPQAYQDIRTRLPLMLDLVKKIRLQIEAGEVDKNSQAVMLPVLRSCIAQVQQLEEIFVKALPRMADSSWSRGKKAFLGVLKESEVEKIDLVLKTNFDLLVHSGMYHSMSRIENKDSTSLQQQMINVVISSPQGYAPQSYSSQQNYGTQSYAPESYAPPEQDYKLRSGSLSSQPPSYAPVFMVPFQRDPKFLERQSIMENIKSKFKTARRVALAGLGGVGKSQIAIEHCYRFREQHPNAHVFWIYAGSAVRFEQGYQEIARRLALPGWDNPKVDILELVHEWLSDERNGEWLMTVDNADDAAVFFGNKISSNSQDRKISKSLVRYLPQSSTGYIIFTTRDKRAGERLAGREKPIEILPMNAVDSLNLLRGRIPEDEWSDDEAMKLVEELAYLPLAITQAAAFISENCLTVSEYLELLATGEEDLKDLLSEDLEDLRRDLDTENSVIRTWKLSFDQISREKARAAQILSLMAVLDHHRAPRMLLRQEGETEVGFRTALGALQAFSLISAEKDKDAAVRMHRLVALSTKKWLELTGMLRHWQTEALRVLSVKFPGRDSYLYENWPVLEALTPHAQLVFSYTFSTAADLLECAKLLDFAALYDLTNGKYSEAYEKCLKSLDIRENLLPADHPLTLDSAQTLGETLLHLGELASARSMLQKAVTGREKSLGELHPDTLESVSDLTITLLELNELAAAEETALRALRGREQILGEDHPDTFVSLNILSMLRQCQGDLESAKETTEKVLEWRQSSLGPENPHTIMTLNNLAVLQYRRGEHELAKNTLMTVLAGEEKLLGADGYDIQVSLSNLALIYCDLGELDEAEAVYRRVLRVQEKLFGPKHPATLQTVKKLADVLVQKGELDETERMKQWDHGKERSQQGEGFGALTMAGLLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1T6</accession>
    <name>A0A1Q5U1T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1T6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="5637" checksum="381ECAECCC98366B" modified="2017-04-12" version="1">MLDLGLRTDEPESIVFDSVQNGESPITLPGRLAGHTTGTKACDISIKWGLAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2A1</accession>
    <name>A0A1Q5U2A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000595">
        <property type="protein sequence ID" value="OKP06605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2A1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2A1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="238" mass="26170" checksum="87B714576C406604" modified="2017-04-12" version="1">MKRTISEFTKVQRRAAILISGAFKSTSAAALNVELFITPIHLLMDQIIQETAIRIQTGAAWAQPDSLCCAPRSSQERKKGGWSPLEALRWKKDGILDPKGSVWESRKAFVLAPWEARILCIIEHDAEAARASHDKIEKESLQQAALDRTPTVLFFTDGSGYEGQVGASAVAPREGVFQRRYLGTSEESTVYVAELNGIEMAIANLSNRPEGRRPTKTVIFSDCQAAIQAVQNPKRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2M6</accession>
    <name>A0A1Q5U2M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2M6"/>
    <dbReference type="OrthoDB" id="4368291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="164" mass="18892" checksum="43BA33E40D26B5E9" modified="2017-04-12" version="1">MLPIPDNLAYPIEEKTWGKSVDTLDEKNQTEGILNGHITCVLRAWKMMGITDRALWNDFREEFDGWTLDTFKVARKTALKMIRIHLTTHGVWIKIAIGVSYAKGLYDCLQEDTQHEWTKEDIEAYLKEHPDNFNSRWNPARDQSPTIRPNASAARATLVNLPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3E0</accession>
    <name>A0A1Q5U3E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division control protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3E0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3E0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="641"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="821"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="542"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP06998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1129" mass="124952" checksum="AB32C82815DA0B62" modified="2017-04-12" version="1">MEQPEAPRAVFHNYLRAFYPFHPAGDVSPSTVTLPLDQGDIILVHSVHTNGWADGTLLDSGNRGWLPTNYCEAYDQLPMRPLLKALTDFWDIIRGGCGSSLKDFGNQDLMRGPIAGVRFLLEKSECLTRESPLVKNYDGLRRIRKALLSDLSSLVKVAKRFQDVANGAPTEDEVESILDEMLLKAFKIVTRGVRFLDVWNEEVGLTRTIAEMETSRNQYDMPLTPASATFSLADTAPISDTCTERNESRQMSHSRMDFSRASMRNEILDHQSRPMSVSTKRISVSHRVSYSGPSSAIRAQNLASERLGTSYDAFLGVLGSFIGLHMQSRSSTELVTTTQQAVQSCRALLTVVEAVCEHDAQRSVLLDEARESMCEKLAELVQAARDVFRPANAHDDDLVFMPDEGKRLVDAATDCVRAAGNCLAKARMVLEQIGDIELDPIEEQRSIDQDVPGIVTSQASPDVPADQEKPQELSLRLPPPPLTIPNSTYTPSTPGLTDSTTPSSFQSHLTSSSSPVHPSASSSLPNSAILPTLSEQASSFSSYDSGFRESHPKSDVSESFGRGVTSTGSTFTYHSHTRDSEMSGLSQTSTRATSPDIGGSIYGSFQVPSLKESISHSTLAEETETEAHLLEKTYAHELVYKDGSVMGGSLRALIEKLTAHQSTPDALFVSTFYLTFRLFATPLEFAEALAERFEYIGDTPHAAGPVRLRVYNVFKGWLESHWRHDRDNDALEFIITFAKTHLTADLPSAGKRLLDLADKVSAVHGPVVPRLVSSMGKTNTAIAQYVHPDTPLPPPILGKKETNLLKQWKNGEASISILDFDPLELARQLTIKESRIFCSILPEELLDTEWTRKSGSLAVNVRAMSTLSTDLAHLVADSILCLEEPKKRAATIKHWVKIANKCLELNNYDSLMAIICSLNSSMISRLRRTWDVVSQKTKATLEQLRTIVDVSRNYAVLRQRLQGHVPPCLPFVGTYLTDLTFVDHGNQSLRCLPTDDGEMAVINFDKHMKTARIISELQRFQIPYRLTEVPELQTWMQNELVRVRSNGEATLQTFYRRSLVLEPREASRSGVNLHAQAQAAQAQAQAQAQTQSQSESSPPNQSILENAKDKFDFLSWTNPSKPKSVATNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4R6</accession>
    <name>A0A1Q5U4R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4R6"/>
    <dbReference type="OrthoDB" id="4326491at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="347" mass="40080" checksum="D457A8025EBC7873" modified="2017-04-12" version="1">MRLRDMVWRTKNLRGVCGSWTRALHHLVFRGKETREGVVLRLRRLLLDKDMETFPMLRDCMVKFCHPHLLKDLYSLQQNIAESAISFEYVYAVVWRDDELMDVMRNKTSHLGYGPYSNEILDTFAEECWALGMKVGDSCARFPNGKVDPSQVTNEWVQAGLVSLENFYIKECLCLWYYNAHMFRQIVGAFPCLEVLEFPAFLHVPLLAKMKYFFPPCEDDSPFASISLSPPQMLQILGITYKEQGPSYSDIMASVKRVIIHTWHYNPILSLFNGGPYGVLSAELHIFLLLNHWMSDRNLEIRQNVIKRITQQAKAAVQDIPEKTKAKVSHFNTDVLMDVMDDTAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5A2</accession>
    <name>A0A1Q5U5A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5A2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="6707" checksum="9C40411FEBB877AD" modified="2017-04-12" version="1">MASTVSDENYNAGTGVLATAWALTAAAIVVLSLRVVAKFRISKFNVDDVVMILAFVRSTCSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9T6</accession>
    <name>A0A1Q5U9T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9T6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9T6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012254123" evidence="3">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="149" mass="16662" checksum="ECE736868FC2AAD5" modified="2017-04-12" version="1">MELSTLLIITALFIAFRIYQSRSAASTPIMSHGKVSNIDNTYASHHSLTSPYANSEVIFKALISSGPVLVDFYATWCGPCKAVAPKVGEFSEKYENVRFLQVDVDKMRGVAQQFEITAMPTFVMLKDGKEVHRVRGADLKSIDDWLQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAJ7</accession>
    <name>A0A1Q5UAJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000509">
        <property type="protein sequence ID" value="OKP09498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAJ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31871" checksum="CFC0CBB5552CC002" modified="2017-04-12" version="1">MVGEVLGRLWKPWLDNPPEFSGESIYIAVVGMTGAGKTTFINKSTNVKIYQVNLIDTPGFDDTKMEESHVLAIITDYLKSGVRLSGILYLHPLNRGRMGWAATRNLGMIQNLVGPENMKMVRLITTMWDRVSPKDGQDEVEELQEEFWSEILAAGAKTDRCIDATEDGKRIIRSILKSPPVRLKFQKEIENGVEPAATAAGKFVADKIVELLGERVKEIKVLQDQLAGLTCDRTKEAERERASQENLQKLNEAQESIKDLKEELRKLKESVADLENSKSGGCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBV8</accession>
    <name>A0A1Q5UBV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oxygen-dependent choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_4661</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBV8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBV8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP09949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="591" mass="64970" checksum="6A89693388FB2AC4" modified="2017-04-12" version="1">MASESDQTYDYIVCGWVGHVTAVQESQLTIDSGGTSGCVVAGRLAENSEIKVLLLEAGQHNKDLENVHMAGGWSNNFDAETDWNFVTPPMAGVDNRQVKLSRGRFLGGCSGCNGTLCIRGCKQDYDDWELEGWSGEEFFNYMKKAETFHSKPWFKADNESHGYSGPLHTEPHDLAPISNLLLDSFVSEGLPLNHDMFSTGDVPHGCGHAPRTVYSGVRTTGADFVTNKNSRGNITIQTDTTVDKVIFTQKGDQLRASGVAAKTSDGGSKIYHARKEIVISGGAYCSPAILLRSGIGPKEELAKHNIPCTVSAPGVGQNLMDHLIVFMFYETEKAGLTTDYHVYHDGNFNKTYAEWKEKKTGFLSTFPFGAFAFARLDDRLKDEPLWKNAPRQIGRDPMGLSPKQPNIEFFTAECYGGPKQYNQFPIDHKHAFSMIAELFAPKSRGSVTLKSANPMENPIVDCNYLADPLDVLVLSEACRFGNEIVMNGAGTKDIVKGSWPSNLSHHTYKTREEWIPYVKEHATTCYHAAGTCAMGKNDDPMAVLDEKLRVRGVVGLRVADCSVMPALHGGHTQMPAYGIGEKCADLIKETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCA6</accession>
    <name>A0A1Q5UCA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDP-alcohol phosphatidyltransferase class-I family protein C22A12.08c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCA6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCA6"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF51">
        <property type="entry name" value="HYPOTHETICAL HAD-SUPERFAMILY HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52058" checksum="2AD38DA3CABBCEAE" modified="2017-04-12" version="1">MSQAAAPNGADAAPHEVAPNEVPAELPIPGEPGLGHTIEIPATRSSISDVHMQRLSLSPSMKDRRGSRNSFGVSLPIPREPRKSSRLSVVGKPTSHVRTIIASELQDQEKEKVQKVKNMCFCFDIDGVLAHGNNAIPEAQAALKMLNGDNELGIQFPYILLTNGGGKTEEARCAQLSEVLGVPISTDQFIQSHTPMQALAEYYENVLVCGGEGFKVREVAESYGFKNVIHPKDILAWDPTISPCRKFTEEEQKLAKPRDFSKFKFDAIMCFAESHDQSTEFQIILDLLLSANGKLLTRAKDPAARDAVAGHIPIYFSQGDLLCPTEHKGPPRLHLGAFRVALEAQYKALTGRDLDRIVYGKPERATYIVADEIIKSWMEEIHGEKKLPENIYMIGDNPQSDIIGGNLYGWNTCLVRTGVFQGKGNDENNPANFGVFDQVYDAVKAAIRKELGDDFKFKWDPKKHSPHGSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD11</accession>
    <name>A0A1Q5UD11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterigmatocystin 8-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD11"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="221"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="441" mass="49591" checksum="8FACC8DD2005DFF2" modified="2017-04-12" version="1">MASTLVPEPGLILSQYQRRPSASHLLTMANQTATPSLLGLAQDILQQTEAITKYLQASNRVAPTFTLDSPDPPHQAPEYRRLHASLKDSLEDLLRLIDGPRKWLRAFCCTGYDLGALQIALDFDFFQLVPADGGIALDELAGLAGLDVDRTARVVRQLMTYRIFDEHQPRIISHSRTSLALRQDEQLRAVVHYSLDEMLKAAADCNVALKAHPYKAHQDLNPFVTRHGVGIFEFYQKNPAKARRFAKAMAGLRKMDGHLDDLLTESFDWSARQGTVVDCGGGNGHISRSLAQDSNVDMLAEGRESLPEALQDRVVYTHHSFFDPQPVRNAAVFLIRQCTHNWADQDVVRIFRAFVPALERSSEETPLLINDIIIPEPGVWPRHEERTVRQVDMVMLVNCGAKQRTRAEFAALLHEADARYEIRNVFDNGPLGLIEVYLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDE6</accession>
    <name>A0A1Q5UDE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000316">
        <property type="protein sequence ID" value="OKP10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDE6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="118" mass="13372" checksum="9B6EE00B3CE67A44" modified="2017-04-12" version="1">MSEAGCVGANPYISPILCRLQTQLMDGTFACSEQGQFTQLLIYLHRPIKIRRQGVNIVSPEGPDELEDAIFEHLIPYHCEGRDYPGYYWMYISLPAFGGYVLNTMGIPKHLLNMFRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDQ2</accession>
    <name>A0A1Q5UDQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier C12B10.09</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDQ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDQ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000123">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial S-adenosylmethionine transporter), member 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="100"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="227"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP10583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34515" checksum="0D75877DACD5C4C5" modified="2017-04-12" version="1">MTQQDDEQPLSGAVAGLTVDCSLYPLDTIKTRLQKARDPSAPKPPRLSLRQTIRGIYAGLPSVLFGSAPSAASFFIVYDGVKRSLLPPSSSPSEPPSRAHVFFTHSLASSLGEISACAVRVPTEVIKQRAQAGLFGGSSLLALKDILSLRHAVPESQTTTGGAPVKRGYGQVIRELYRGAGITIAREIPFTVLQFTMWESMKATYAQRYLRREEGTSIKESQIPASTSAMFGSVAGAIAAGLTTPLDVIKTRVMLARRGDGGVDAPVRVKEIVRGIAQEGLGAFWRGIGPRVAWIGIGGAVFLGSYQWAWNTLEGVKKEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDU1</accession>
    <name>A0A1Q5UDU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="12018" checksum="75F068B7DFEBEFA2" modified="2017-04-12" version="1">MLGWLGTTGRTPRRRQRRQLASRYQLDSAEASLPYICALHGTSASAQPQRDNLRWDQSRHNKIRTWVSDFRADLHATLGGEKMQEASSRVIIASIASITVLPHHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE44</accession>
    <name>A0A1Q5UE44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE44"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="673" mass="73994" checksum="91E3CD7DAF2F18F7" modified="2017-04-12" version="1">MEVPKARGAGRSGPRRRTGCLTCRARKVRCDETKPSCSNCDRLRLHCAYKPPIALGSPWSASSRLTHDQTTTAVAHAISQTGPAPALGPNTAAAVVAAASQRSPDINFFNTVLRSDEQHRGIAAPAAPVRGLPTDPVSFPPELGGSFDMLGFMGGITSELEQKHLDLTSGLAAFTTSQTPRSLAAGIAVATSEEGQLVGERRSPLSPDGSSSLVDGVSIGSASDAATTRGSWPDPGSTTYEEQLIQHFLAIDPPAAIFGPVMMEWKYVRPSILAHARDYGPLLNALYCYSDIHKAMIEGKQWRWAPTYYRVASSEIQACLQGEVTDATLVKVFATVFFLMLSEVFSSPELCAPGTSYLHSAYLLLQRFDDRTQAWTGLGHLLVSWVSLLDVKSLIAGRDGDPLTGLGHIAEHEQVGRIPEQPRGTASPEERKMEDSNEDPFRSPSYLVYEAIVGPAFRFFFKAQQIVRRIVCIDLHHRSRGTLSDEFEVLQIAHKVGADLETLWHRRPSVIDVYGNPDALTDTLCAPVAHEVCRTFRQYMATFLANFIYLHRVAFAIYPRTDRVNGAVKQIIHLATVESAGLESGHLPVSFLWPLFVAGLEGSPEQRQWIVQEMQRMVASPDSDPASSITCHPSAEKVIVLLEEMSRRQDVSRSWADSRCVRRELFTDFFFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE50</accession>
    <name>A0A1Q5UE50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-1,2-mannosyltransferase MNN21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_4052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE50"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="496" mass="55679" checksum="218D3444E79FDAC3" modified="2017-04-12" version="1">MGMFRPGRVRSLVLAFLATILVCIVYLYWTPTVASSTVSVVPSTAFEVPLVERQKDFWKAFQPILERHNPNCPSPEKNGDAGANHFDPVKDSPRPDLTVMSEADQKAMEDAHANFVEDIKKAGKDLKPVHTPGKRGLVSTAGATYLPVFVSTLRMLRRAGSTLPVEVYMKDTGEYEKHVCNDILPNLDARCLVLADVVGKNVIEHYQLKIFAVLFSSFEEIVWMDADCFPLGKPEELLDSEPFTSTGLVTWPDFWASSVSPLYYKISRQEAPPMSARQSSETGVFLVSKKTHLFPLLLAAYYNFYGPSHYFRLLTQGGPGEGDKETFFHAATALGAPFYTVSERVQAIGHQNGEKLSGSAMAQTDPREDHALTTQDKWRVKDPAVAPPPHIFFIHANYPKFNPGDNVFGMGWETTPTIKEDGSDTRAWTAPPDTLSRFGYDVEKAYWEEIKWVTCHLENVFKSWEHKAGLCVKVEDYWKNVFAEPHDDDPKFTPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFD7</accession>
    <name>A0A1Q5UFD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_3208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFD7"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="24716" checksum="2ADE74DCE4F9DE27" modified="2017-04-12" version="1">MPSTTEVAQQFDTIEDTIAAFKNGEFIIVLDSQDRENEGDLIIAAESITAAQMAFLVRYTSGLICAPIPPPLATRLALPQMVTENADPKGTAYTITIDASDESVTTGISAEDRALTCRTLASPSARIDSFRRPGHIIPLQARAGGVRERKGHTEAAVDFCRLAGKAPVGVIAELVEGGEVVEGVAEIRGNNGMMRRDGCLRFGKQWGIKVCTIEDLVEYLERTEGGKNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFR6</accession>
    <name>A0A1Q5UFR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFR6"/>
    <dbReference type="OrthoDB" id="4161095at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="201" mass="21912" checksum="89AEA7B57A722D75" modified="2017-04-12" version="1">MSDSYTSSSYYYSSTSKGDSGTSTTTGHRYTTTSLTEADGTTIVRTARQDLGQPLIIEEHRYDSTGQEQLALPGPSGSSAGGVRRITDLDEEGSSELSAFDAEASFSSGATPQFDGAAVPFGTRVVDVDTGAYDEHMHYFGDKSMRHHRELRDASGRKFTRDVDFDPSGRSGTAHERRRFENPETGTEVEKDDDVEVSEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFR7</accession>
    <name>A0A1Q5UFR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein sly1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFR7"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="703" mass="77062" checksum="ED96B19AF924279D" modified="2017-04-12" version="1">MAHPMSLRDRQVASIQKLLNLNHDPKPADDNAHESSTHGGLISQSTPILNEDGDPIWKVLVFDGMGRDVISSVLRVNDLRTWGVTIHLNIHSQRYPIPDVPVVYLVEPNEANIQAITRDLSQGLYSPAYVNFLSSVPRPLLEDFASQIAASGASEHIAQVFDQYLNFIVAEPDLFSLGLGNDAYYKINSGKTSDEDLDAIVDKVVSGLFSVSVTMGTIPIIRCPKGGAAELIATKLDRKLRDHILNSKDNLFSGGQRALPGVPSSRPVLIIMDRNVDLVPMLSHSWTYQSLVQDVLQMRLNRITLDADEQGSGKVTKKSYDLNSNDFFWQRNAGAPFPQVAEDIDAELTRYKEDANEITKKTGASSIEDLQNDTSASAQHLKAAITLLPELRERKAVLDMHMNIATALLKGIKDRQLDNFFELEENITKQSKSQLLELINDPAKGSNPLDKLRIFVIWFLSTETELNRAEMTQFEEALTKAGVEDVTPLSYVRQVREITRMTMMTTAAPEQQSSSDLFRGFSSLSNRLTDRITSGALGANFDSLISGVKNFLPANKDLTVTKITESIMDPSAASSSAIAKTENYLYFDPRSANARGAMPPASASRNTQMPGAMGASAPGINATFGQRRQAFNEAIVFTVGGGSMDEYGNLQDWVHRTSGQAGADGATSANRTTGRRRVVYGSTDLMNATEFLTDSLAPLGRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFS1</accession>
    <name>A0A1Q5UFS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine transporter thi9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFS1"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="555" mass="59680" checksum="F10D1934AE05D141" modified="2017-04-12" version="1">MVSADAMAVSDAAKTELDAQNTDHLLSVTEEDDRDLLKLGYRAVLARGWGTFDNFACSFSALYCIGGIRVLFYIALSNGGPAALWSSWISGSILSIITAACLAEACSAYPAAGSIYYWAFRSWGGGRLGRFVSYLIAAWTLVAWTAFLASDSFGVANYLVSEVVIFNPDTTFPYSTSDVKARAVAWALSLGFLALATALNFLPPRMYAWVFRTGFAVIVVDMLLNFIWLPIGVSKTYGFQSAEFVFTSVYNGEGTAPSLNWVLSWFLVSSCLVGEDASGHVAEETISAKKAAAKGVFWSTVASAVCGFPIIILFLFCMPSIETFYDTTAPQPFINMYALALGPHAHVVMTIISMIGAILNTSISLVAVSRLVFAVARDGVFPFSDVLSRVSKDKQPHNAVIFIASIAALLLCTQLPSQVAFASLVSTSAAGSIAAYGLVGIGRAFITRTSFRPGFWDMGWFGAVAAVVTFIWNTFAFAVLCAPQYSNAAIDEESGLFNYAIVIMGGVTIIALFEWWRKSKDDWFQHLKGSDSSSGTDTPVEQDATINASGKEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG20</accession>
    <name>A0A1Q5UG20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG20"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="186"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="408" mass="46255" checksum="BD65BD4C16A6C76E" modified="2017-04-12" version="1">MANQLHSAPPFRAEHMGSLLRPDNLLEVRAKIRDTGISEEAAGLHAVEKEAVKDVVQLQRDLGYKAVNSGEFNRTRFWGLMWDEFQGTIRLQDAEASMFRLYHPDVVSLIEKDRKVMPGDSVIAGSKLSWSAEQSVSNLHELKLVQASLPESEWGNIKLTMITPAWFHMRYKQGKAYTPEAYTNDEEYFADVAQVYQDELDALYKAGLRNVQFDDPGMAYFCSKSFRQGWEEDKDNIGSVDDLFDAYVKLYNDCLAKIPADMHTGIHLCRGNFIGGRHFAEGSYDIIAKKLFENLNVNTFYLEYDTERAGGFEPLKFLPRNKNVVVGVISTKLRDLEDKEAMKERIYKAAEYVASGSGESREEALKRICVSPQCGFSTHESGYPLSLDDEKKKLGLVRQIADEIWGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGQ0</accession>
    <name>A0A1Q5UGQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sphingosine N-acyltransferase lac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2732</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGQ0"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="164"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="418" mass="48100" checksum="1FF6D8434DA8C059" modified="2017-04-12" version="1">MAAPTHSQRPPVCGGSARRRKTEQATATVTITATATTPLEPASNGHVQHEAKTARPRKKPRSLLRRLKRRAIKHTWSIPLLLLVAFASLYTLDPTDTNIIHHFIFLSYRQDPAPGTPGPAQYGKGLWDIAFVSFYTIVLTFTREFIMQELLHPLARACGIKSRAKQLRFMEQMYTAIYFGISGPVGLYVMRRTPVWYFNTRGMYEMFPHRTHEAVFKFYYLFEAAYWAQQALVMVLGMEKPRKDYKELVAHHIVTLALIGLSYRFHFTYIGIAVYITHDISDFFLAVSKSFHYIDFPLVIPFYALNVGTWIYLRHYLNLRILWSLLTEFRTVGPYELNWETQQYKCWISNIITFALLAMLQSLNLFWLYCLLRSAWRFISTGEKKDDRSEDEEEGEGEGGLNGNAKVNGSGNGVAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGX1</accession>
    <name>A0A1Q5UGX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGX1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGX1"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="725" mass="78851" checksum="6EE6173BAF43AF72" modified="2017-04-12" version="1">MTDLEIPETGLSLRPGDQPGDAAAKPAQFMRLNLAQNTLDELISSLRSDDSTAKVRLGKHPTLHFGNKTQSFHAYPETHRSEIYHTSYDKQNLYFTGVMSHSLEVEKAREATAATDQALANLEESLNAFERGKASKSTHMIQTPEELKALRATNSMNAMHRTSKTKSVLEKDRLLRNANNRSLTSSPTLGAPRSPLPGMTPTSAPSTQAKDSARLQALKTPFIHLLAIRPVSAKFLARQTRSTIEDCTALVQKYGTENRIDREKYDLKDKFYKDLDVWKFPYPTQDDRQAAIDKAISAFDRMRLSRTDKLWQSLLPKEERGKGKCLSKLNLQSGLAGKKPATPRMTMDGADDRKDGDTTGNETDRPKGTPAAAPKKSSTPAAKARVEKEAAKRPAKNKNTNSTLTGRITKKTGGRPPAKAATETKYKSAEFVHDSDESDDELPDASPPPAPARAPSPAPAERPKPVKATAAKKTTQPPAKKTTQVLTKPRLKEDTPAAPTPKVLKAEAPTPKLEATKAAAKRPPSVRLSTSPQKPSPLSSPPASASDATGRSRSDSNNHSSSSSSSSPLISQLGRAKATGAVSSLLSSTRPANGASKGGPASVNPLKRKAEPERPAAATPLGARATPSNNEIKRRRAVSTSSGGSTGSASPPMSHKVAQRQLWDKSQRFKKAYAKYRSLHDDLAGQVNPRADMITKLEDWHQKLTQMKKEIWEDDRKLRRDGSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH09</accession>
    <name>A0A1Q5UH09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH09"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="87581" checksum="8A173F287EE2D7E8" modified="2017-04-12" version="1">MSNVDISSDGLIVDYDSRGYLPQSWPVAVDQNPSRPEDAHDLSPLQTSGHPLEQSVAQDPNLMVDWHYHHQLQQTPHHHPQLSYSPEDPSSAPQFTAASYGMAIQSSPVDLMSAGPQGQMSAGLLDSYHLPLSAPVDMVPFTYHDFQADLMTFNGLPDVSYAAPHPILESSSPTDTYLEVRSLSSSDNGWSTVDHRRSLDFGFPEQGIFVNPTQTLHDRSLSESSYSTSYNSFVDIANPISSPGSDGHMDFPYNNHSAALSLATSPTSTSMVHRVTEEQSSPVSGSGSGSGSGSGSGSRSPSAVSPSAMVRPIPVPIKKSTSPTRSSGSHSSASPPSRKPSRKSPIAAKTAETKIRKQSQTGKPETTEKRVGKRKGPLKPDQRKQASEIRKLRACLRCKFLKKTCDKGEPCAGCQPSHARLWQVPCTRIDIKEIGYFMKDWKADYERHISMGFSVGNIKGFSDQERTLYITHGYGQILPIAAREVFVRDEQCFTVDWVESIHREPTPYEVETAKLSAGMEGISHAMLSDYLDRHIDGNGTFEKFVDDYFEGTPFLTQMLKTAFRYYYRTKLPVIRKALKLIIAYNLTLHVTMVEGLGDEDGFLGRINEPSSKFSGKTMAPVMINFQIKCAMASMWRELQKDVLEELSALYSSVYSGDKLKNWPTIFVLASILLAVWEEMQFDCHYRTPDQAAVDKFCTDMETTPVGVIVGLFQAISQKLPPFTEWDSQKHHHLLYSNPDVCNTMTEVRQHVEQHESYLRGRTGTQFDRGDFDCLSNKFVSRLVIRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHB2</accession>
    <name>A0A1Q5UHB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-containing amine oxidasedehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHB2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHB2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61979" checksum="C1A03CBA5D0CA8D7" modified="2017-04-12" version="1">MSKISSNFKTPSIASEYKMPGDRNRKVAIIGAGAAGMSCAATLANHPDKFHVTMIDTDSHTGGQATSVSLDEEKHGASWLNDGVQGGSAIFRHTFRFFRRYGYEPQQVKLQVSFGKGRDNFWTNVFPSPLVDQHSREIKKLGRVLKCIKYLMPILGIMPVKVILRLFRFSDDFNNKMVLPLLALFLGTGNQTPNVSSVLLERLFDDPQMKLWEYDPDTLLPNLPEMYTFPNLGNFYRDWAKDLTAKGVDIRLNSSVAILKRGKEGVVLQIERHSGDGDQAESAYPPETFDELVLCCPADEAKKMLDRNATWREKYVLGGVRFFNDITITHSDSDYFQKIFEAQYDSALCALATTKERAEQLEFAGQQPRCEKDGWVGFRPMYFTHSFESDPDMIEMGFDCSNYQHQFRERLGAGSKPRPLNEHVFQTIFLNDQQKDMWTWNDIDPSKIIARKWWHQFGHRWQHYLRVVPGMMFINGKNKTHYAGSWTMVNMHEIACISGIAAAYQLGAEYDPFDDFAEDFFAKYLLVCHGTRYKRGKNKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHS4</accession>
    <name>A0A1Q5UHS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHS4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHS4"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="36"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="477" mass="50943" checksum="C6FFBDDA9A65D00E" modified="2017-04-12" version="1">MAGTPVYNASEPNGGDPLKVDVNAQFEGFEWDYTYIVFCGFIVWLIIPGIGLLYSGLARRKSALALLFQSLMIVAVTTFQWIFWGYSLAYSRDAGPFIGTLANFGLKNVMAAPSPGSAVLPEIVFCFYQLLFCACTVMIVVGGAFERGNMLPSLIFSFWWATVVYCPVACWTWNSNGWLYNLPSLDFAGGGPVHIASGWSALAYALVLGKRKHVDETSHGKPHNTTLVFLGTTLIWFGWFGFNGGSALNASVRAMLAAFNTNTAACTGVLGWVMVDSIKNRGKFSVVGACEGAIAGLVGITPAAGFVSVWLAACIGFLTSVVCALLQDINNWLHIDEGMDVFKLHGIGGMVGAFLTGIFASQSVAALDGATEATGGIDGNGMQVGKQLAEVCAISAYAFIVSCILLYILKWIPGMHLRVQEEAEMIGLDRAQFVDEQIGERVILDELFGSSSSTTPAHASVVNESVGISAASKDLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIA0</accession>
    <name>A0A1Q5UIA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIA0"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="36"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="61331" checksum="2BDACB7E19FEC97A" modified="2017-04-12" version="1">MTTPNPEEATQNVRRAEENVLGAFGAQEVLLELVPLYFQYVHNIAHTIFHEPSFLHRLHEGKASMTHVYAMCALAARYSENRVFNNIARCARGKIYATEAIRRCHQHMVARGLETVQGFLLIGFYFGGEGDIRGKHVYVGLARLHAELLSPADTATVVLREERRRTWLTIYIAVHWSASDMAVEPVSPFHDMAPLPEIDDADFQTLGPEQLVESRTSPSSRCDMWAQMGRTLNIYTRINVLLRRLSQNAISFEEFCKEAAVLEHGLDQWAKNLPPNLTYSYDNFMLMIDKKVGKTFLSMHIGYYHFRQMLLFPFLDTRLARWTTRDRAAKCKESATIVSDILQYSQTTPQCKMEYFIYGHIAVVSSSVHLDTLLCSDDQSDLSSARQRLVFNFQFLMGLKSYWSVVEHYVTHLRSFQNYCRDSMSDAFVLDNWMARFLTEHSSALSERRDNSAHPPAARVDEPSSYQSGLNDGVPSGSSSDSQMEIAGKSGVIGTKPTLDPAVEFNDLSQLLDGRGMSGEAIVNSALNWLLEDDLRLEQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIJ3</accession>
    <name>A0A1Q5UIJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIJ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIJ3"/>
    <dbReference type="OrthoDB" id="4368574at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="30"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="219" mass="24452" checksum="EA9B09B49CB3D36E" modified="2017-04-12" version="1">MTMSSTTRLSSISCTSGKPVLQVLVLQVPVLQVIDAATSFGATRFLRDMSARNAWDTLRACWIDIYQGPPDYVVHDAGKNFTSTEFKQLASSMSIKVREVPVEAHNSVGKVERYHGPLRRAYEILREELKDENIDREMILQMAVKAVNDSAGPDGIVPTLLVFGPYPRMTEIDPLSPLVVKRAEAIRAATKEVRPLHAERQVNDALAMRNGLLPEYVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIV9</accession>
    <name>A0A1Q5UIV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIV9"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013248284" description="ASST-domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71852" checksum="A249F3A34D9D2138" modified="2017-04-12" version="1">MTALRSPSITIYALLLLVLSISGTADQEPRFRSQKYAKGFDGPYPLQRYRSADVSGPILNYWRRSVACQDGLYTILAPRGDSVRQSGPMIVDDQGHLVWFKRYKSTYNANVYMYKGERYLTFWAGDDSVRGHGEGSYYMLNSHYEEVYNIHGANGMHGDLHEFQITRDNTALFAVYKSLPADLREIGGPKNGWIYDGLFQEVDIETNELLFQWRASEHFNLQESERDREESDGDTEDNPWDFFHINSIDKDWRGNYLVSSRYMSSLAYIDGRTGDVLWKLGGKQNSFLDMSDGVATNISWQHHARFQIKHDTNTTRRLSLFDNSSRGEGAPENTSRGLIVKINEETMTVTLVQEYWNQVPISSQSQGSMQILENGNVVLGYGYSAAWTEFTADGETLCEVHFGPQTQFHRGQVLSYRVFKQKWVGLPLTKPSVALSGSEAAVSWNGATEVVTWVLQGALPRGEESGDDSVNAVREFQNSEKIGLEFEFISAIPKSGFETIIPIPAGTVYAKLRIIALDKKGITLGVTEALDWEPEEMNNEVAVYSGEEKDDEEGGDTGEVWSASAIGIGLITVAILGFSVWLVCKIAYSRSLKNLFTREKDEHTWQRVSTGEELDELDGFSDVESRDHASDSLLKQPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIZ4</accession>
    <name>A0A1Q5UIZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000213">
        <property type="protein sequence ID" value="OKP12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIZ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="671"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="841" mass="95820" checksum="FF28502360018472" modified="2017-04-12" version="1">MLQSQQTEVGSSQLSLFDSEPDDLSFITPSNCPATPSTSWQVDSFSFVQPSVPSSVAPDSLERFQRVGPGRRGQFFLYSGMNHSDWVDWWLETDYGSNNKITWESQHGSASETWKQFEQVAHTGTGSPKVMCKRCDAILEHPYATKKDANGRVGRHGTTTITRHLRTLTCQKATGVRQQRGGLKGFLHSGHPADRPFSQEAWEDKLLQFITINRLPFNLVEHPTFRDLISHSQSAPTPSLPIIQSADTIRRRLSVRVKERQRDTLGLLPEHVKISVALDCWTSPFGQAFMAITGYFIDADWVYREVLLGFKPLHGTHSGANLSAVLMRTLTEHGIVDRVFGLTTDNASNNKTLVDTLQQSLSGDINVIRVPCLAHVIQLSLNQLLDRLKAVPLNDTTETTWTHRQVNLAKANAQSKEISHTLNKVRYLAIYIRGSPQRRELFTAVQPLGQGLMPIQDVRTRWNSTFLMLRRVKRLRFFIMKFCDQFNCEDLTLGDDQWRQIDYLLCLTKPFFDYTLALSKTRDVTSHLVFQIYNLLFEHLERSKIQLQRKRVVWKKQMLTSLEASHAKLSEYYEQTDHMRGHIYAVCTMLSPDSRFQFFLSDDWADAKKLRDQYRVAFQDALTPIQERLSSANAQGPQGSSSGSTPRSFLHNLVRSQKSHSKVTPGPAIDELTQYLDGNVTDSEPLSFWRENQSRFPAIATLARDVLAIPATGSGVERLFNTARDICHYRRGRLKSETIEELMLYLCTSRFELEMQEAKDLEEFFSSNEIQALREEKNEYPDNVDVEAEEISDTEEQGDEFGSSDLIDADDDGATITAAPSQVRTSGRKRKHVDDELYERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ04</accession>
    <name>A0A1Q5UJ04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ04"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8474" checksum="4A48972EDAC7E965" modified="2017-04-12" version="1">MADDYVTNDQDIPVQDDIQDVEDPIDEGMANSDQQLANDEKEAIDRSNIINERTRHAKPQTDNGYNEGPSEEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJN7</accession>
    <name>A0A1Q5UJN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067149" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="183" mass="19288" checksum="10DF487D3FBDD56B" modified="2017-04-12" version="1">MQITSIFVLSTTLLAAQVPAQFIRSMAPNLPTWSGQASHAVASSMATPSPSSSIVVASQPSHYMASHSFLPMVHRPMRPVARPSSSHSVVPAATPSASSTFNTQDQHQGLRQPSAQSPDQAYAVPDGGLAPIDPLQPGSDVAPVLIQKPTGIDEDQKFLLSSILHGDVFLDERTNNIGCGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKS1</accession>
    <name>A0A1Q5UKS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKS1"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="15"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="39223" checksum="6003B7BEE920E586" modified="2017-04-12" version="1">MSKAVYISTIDGKPGKPGQVYYPLTLRTLPQPSPQGRELLVRLTAASLNHRDLFLRQHLYPGVTFDVPLLADGVGIVVGAGPNVSNADKWQGKRVILNPGVGWKDCPDGPEEATGYRIMGGTKFYDKGTLQEYITIDESEVEEAPAHLSDAEAAALPLTGLTGWRALVSKAGERNSKDGAAILVTGIGGGVALMVLRFAVARGAHVFVTSSSQEKIQKAIELGAAGGVSYKEEGWDKKLLGMLPSGKKNFDAIIDGAGGDAIEKAARLLKAGGVLSVYGMTVSPKMPFTMQTVLKNIDVRGSTMGSRKEFKEMVDFVAANKIQPVVSRVLRTDIDDLSAIDGLFEDMKQGTQFGKLVVEFGKASGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL08</accession>
    <name>A0A1Q5UL08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL08"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL08"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="312" mass="34671" checksum="44849FF0058C874E" modified="2017-04-12" version="1">MFDLPDAKRVRRDQVQSPASSREHSPVDETDLQDAHARLGKLLDLDGLIGANTSAEEDKDATQPADGNNDEDEQEFEFRLFSAPTKPKDATPKEPGTKDGDRTATKGDKTEGKEIKVTTAGTQKLRIRLRSPSPSGDPSEGRFVKAFRGWQYYFSTPSLLGLDENEEVKETIAEQRRQFEDMAVTGEHITIWAKTQPWPGCDLPWRVIHLKRHQTKLPKDIPVYAVEGAPVSKSPLTRKKPGKKRRLQLRKKVAAAAAAKESEAEKRHRKNRERKLKRRQKAREQKAAAGGITGDGDVAMADGDGDSSGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL17</accession>
    <name>A0A1Q5UL17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Siderophore iron transporter mirB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="52768" checksum="934139B56753452C" modified="2017-04-12" version="1">MTIFTADTTALKNRAFWIAYAASPYLITPWIYGYAADQIVAPGGIGYRWSFGIFAIVMPIVSAPLWSLWYCIQEKAEKTDLTEKQSSGRNLLQSIIHYGIGFDVIGLLIIATGFSFFLLAFSLYSYQPGEWHSPLIICFVVIGFCLIVCFTLWDKYLAPVKFMPWELIQNRPVFFAFSMVVSLYFAWYICDNYFYSLLQVMFDQTVTHATYISNIYTIGSCFWCLVFGAVLRKHGRLKWWAICFGVPLTILGVVLMIKFRQPDSNIGYIVMCLIFVAFGGGTLVICEQMTVMAISAQRNIPAILAIEGVVASIGSALGSTDAVAMWTGVFPVKLKEFLPSSAQGELTAIYGSLSTQLSYAKGTATRDAIDHAYKETQNLMLITATCLYLITLASWLILEGSQREEDEAAGSWCSFLSEMCPHSAQFIASVMSVLYIALYRIYSPRSWKYTQCTVPEGEADGLICNFPSTIAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULC7</accession>
    <name>A0A1Q5ULC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULC7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULC7"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="56051" checksum="FE2F4B4AE5D2B426" modified="2017-04-12" version="1">MAAIKETVSNLINKIAGSAEEAPREPSTEEFQALQKKYTDAGQGQVFAFIDELQTADKSRLFHQLSTFDVTRINELADKALNPPKTDETPATLEPLPSSATASIIDSDPADLKAWYDAGLKQVAENNVAVVLMAGGQGTRLGSSAPKGCFDIGLLSEKSLFQLQAERIAKLQQLANKANGIDSATIPWYVMTSGPTRKPTEEFFAKNKYFGLKEENIFIFEQGVLPCISNDGKIIMESKSKVAVAPDGNGGIYQAIVTSGVREDMRKRGIKHIHAYCVDNCLVKVADPVFIGFSASKNVDIATKVVRKRDAAESVGLIVQKNGKPDVVEYSEIDQATAEALDPQDSKLLKFRAANIVNHYYSFNFFESIENWMHKLPHHVARKKIPFINTENGELVKPTSPNGVKLEQFVFDVFPMTPLDKFASIEVRREDEFSPLKNAAGTGQDDPDTSRADIMKQGQRWIEAAGGIVITEDDKFGVEVSPWISYGGENLEFLKGREIKAPALLEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMR4</accession>
    <name>A0A1Q5UMR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylosuccinate lyase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMR4"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01597">
        <property type="entry name" value="pCLME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF2">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="2">
        <location>
            <begin position="398"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="52576" checksum="B3A6DF5584A2E8C1" modified="2017-04-12" version="1">MSMFLRLARLPQATTGRPIVAIASTNGRRSIGSVSAIDSSIFRTLFGTEEIRKVFDDEAYIRRCIDAEAALARAQSMCGVIPKDIGPRITQKLEESNLDFERLRHETEIVGYPILPLVRQLSAICGDEAGKYVHWGATTQDIMDIASVLQMKQGLDIVERLLKDVIKTLRELSEKYKDTPMAGRTHLQHALPVTFGYKCAVWLSGFQRHAERLEQLRKRALLVQFGGAAGTLSSLGSGDDGVRVRKALAEELGLNDPSITWHVARDGIAEAVNLLALIGGTMGKVALDIMIMSSNELSEVAEPFVPHRGASSTMPQKRNPISSEVILAASKILRSNAGLVLDGMVADFERASGPWHLEWVAVPESFVIAVGALSQTQFALSGLSVHTKQMLENLHSTKGLIVGEAVMMGLAPHVGRQRAHDIVYEACRESIENDRTLLESLLEKDEVTSKMSQQRLAELCDPVNYLGSSARMIDDVLAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPE7</accession>
    <name>A0A1Q5UPE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent protein deacetylase hst4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_14131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPE7"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="566" mass="61820" checksum="6CA15FC18C1CE27C" modified="2017-04-12" version="1">MEPLDPNDLSDTSELTELSSAPPSLRSSPERYLTPSSQDSEDSTRQDCPPPAKKRRRNPLPKERTTQYLYLSKSSYEQPDQVKLLVDTLRHQKDIVAITGAGISTSAGIPDFRSTDGLFKSLQKKHNLRASGKLLFDAAVYQDDALTGPFHELVRSLSVEAAKCQPTKFHEMLASLGKENRLKRLYTQNIDGLETSMKPLETEIPLSVKGRWPVTIQLHGSITKMVCQKCRYLKNLDPEQFCEADPPDCDECADNDKARFVAGQRSHGVGRMRPRIVLYNEHNPDEEAITSVMNADIKSRPRVLVVAGTSLKIPGVRRLVKSLCTVIRSRKDGVTMFINNEPPAGKEFDNCFDLIVQGSTDEVADLVKLKSWQDPEPYAMPLPEPVFGIKPASDEELSASDSEQKVAVVITSTPKKRPRSDTGLMTPSSSHDEKPVVKKLTQRKIINPASSGKSINSLLKSSDSKPTAPAKGGRKPAAKPAVPRKRATKPKTAPAAMKPISSFATVSKANKVTVTVDKNSDPAKLTRSLPLGAARGNGSAKPGPLFPGLKAGVETHQFEEATTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPT5</accession>
    <name>A0A1Q5UPT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_14008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPT5"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="32263" checksum="DD5A823B3EF33DE0" modified="2017-04-12" version="1">MFSRTVRPAVRAGSAAVARTAPTNAANFATLREIEGRLKSIRNIEKITNTMKIVASTRLTRAQKAMDESRNYGQTSNTVFEQAETKPLEDKKTLYVVASSDKGLCGGIHSGLSKATRRLLAGNPEADIVILGEKAKAQLSRVAPEKILLSFANVCKDIPTFADAQAIADQISLLPTDYASIKIVYNKFINAQSYEATTIEAFSEEAITQSANISAYEIDDEALAGLREYALANNLFWAMAEGHACEISARRNAMENASKNAGEMINKFQILYNRQRQAAITGELVEIITGATASADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPW0</accession>
    <name>A0A1Q5UPW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000084">
        <property type="protein sequence ID" value="OKP14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPW0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPW0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="81"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="422" mass="49045" checksum="DCCCB47B6D3A7350" modified="2017-04-12" version="1">MVKYDVATRTAAIMMSVFGMEPRYISDWTGIPTETVKAIYNRAIERGFDPSKRPFTLIDAYVADATRTGRPRKQIPALETAVVAKVRRDRYGREKTCADIASELLDISATTVWRVLRNAGLKKTKPTRKPGLTDRMRTDRLNWCLEHQHWTLEDFKNVIWTDETSVILLHRRGSYRIWRTKDEAFLRSCIRERWKGSSEFMFWGSFSYDKKGPYHCWLPETAAERRNSEALINTWNADLEPKLRAEWELTSGVRRINLRGQTPGKKPIWRFTTKTGKLTRSKAKGGIDWYRYNTTILVPKLLPFAQACMVDRPDTLVQEDKAPAHAHQHQQVVFDMAGVSRLLWPGNSPDLNAIEPAWPWMKRYTTKKGAPKSRADAIKAWGEAWHTLPQERIQQWIERLPRHIEEIIRLEGGNEYKEGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ19</accession>
    <name>A0A1Q5UQ19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ19"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="57"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="511" mass="55249" checksum="97CFEB3EFD2DA584" modified="2017-04-12" version="1">MSSTKSPADEPTALGSTPADGDATPPDSSLDTAYKAKADRLNRAIQDIGMGRYQWQLFVVIGFGWASDNLWPIVTSLILPPVAYEFHASKPPFLTLAQNIGLLIGAVFWGFGCDVFGRKWAFNLTIGITAVFGLIAAGSPNFGAACAFAALWSVGVGGNLPVDSAIFLEFLPGSHQWLLTVLSVDWAFAQLLATLVAWPLLGNMTCGSEEGCTRSKNMGWRYFLIAMGGLAMIMFVVRFVFFTIFESPKYLMGKGRNAQAVDVVHEVARRNGKTSPLTQNDLDDFDEGESHGFTASNIVRQRLDKLRFQHIRALFDTPKRAYSTTLIILVWAFIGLGFPLYNAFLPYIQQSRGIEFGDGSTYITYRNSLIIAAMGIPGCLLGGFLVELPRFGRKGALSSSTALTGVFLLASTTANTSNALLGWNCAYNFMSSLMYAVLYAYTPEIFLTKDRGTGNALTASANRIFGIMAPIVAMYANLNSAAPVYVSGALFVAAGILVVLLPYESQGKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQF3</accession>
    <name>A0A1Q5UQF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000450">
        <property type="entry name" value="PAF acetylhydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012411798" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="395" mass="42614" checksum="DCF04CBDA67C4812" modified="2017-04-12" version="1">MFKPSEKRLLLAGLFTQLLPSIGAVSFPAGVGSFNTSIATTQLVDHNRLDPYAPTPQPRTLMISLFHPVPPATCCPSLTSYMDPISATFEDEEYAPVGIPAGAFGSLTLQTCKPCPASNPNRRVKESKYPLVLFSSGLGNSRLLYSAMAQQLSSTGYIVVTIDHTYDAGIVTFPDNSTILAANITTDTQIVDDLNIRVKDVSFVLDQLHRPSVISRLVPGRTCGMDTSKVGIYGHSLGGATAAEALLSDPRLMGGINLDGTFFGSVIDRGLNKPFMIMAHEGKNLTTDASWAALWPKLKEFRRGFMLSGSTHGTFTDLAEAANLIGLRERFPTEVAALLGSIEGERALQVIGAYTSRFFDFVLKGKKTSSIESGEFMMGPLISCSLNRRLFGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQI2</accession>
    <name>A0A1Q5UQI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQI2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="175" mass="19924" checksum="FCA0F4909D163DA1" modified="2017-04-12" version="1">MPALPSDEYDADPSTPESQRAEELQLGQLLRRQSPEDLSHYENALVEAKPEVGGILESIQVSDSAFPAKIDSKLYPPIFKNSTVSKSAVKEFRQMLARYNSRRRAYTALRPRVKKLQPTSRKFMVERLQPLHQEIETLYSMLIPLFGDNINEPKPQMKISAAAMRPLHLGFNQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQY6</accession>
    <name>A0A1Q5UQY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQY6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="10158" checksum="FC01168513F50EEE" modified="2017-04-12" version="1">MSDKPSSQEPAHQHEGFFERILHHHNQNEDAKYQKEPDQDKAHKDDHDHDHDAHKKKESELDKMKDYLHEDEELEQEGRTYGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR63</accession>
    <name>A0A1Q5UR63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Riboflavin transporter MCH5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000037">
        <property type="protein sequence ID" value="OKP14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR63"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="36900" checksum="01D68DDA29CD2B41" modified="2017-04-12" version="1">MLVIGVLCGRALDAGYFYVDITLGVLLEVFGTMMTSICKEYWQVILAQGLCVGIGAGMSFIPSVAIVGTYFSTRRSTALGLAATGSSVGGIIYPVVLRRLIVQIGLPWAIRVMAFIMFGTLLLISVAFMKPRLPPRKSGPLINIESLRDTVFVLWLFAVFFIFIGLYIPFFYVEQYGINLGISRDLSFYMLIIMNAGSIPGRVIPPIIADRIGNMSVMIPSVLLTGILMLAWISVESQSGLIAISVFVGLTSGSIQAVLPATVAFLCPDLSKLGTNIGMTLFAASLKLLISSPVASAILDHQRTSEGDISWGTFTFSALFILAGGVCLIIARVFKVVFALKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URI7</accession>
    <name>A0A1Q5URI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter G family member 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_3050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5URI7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1143"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1172"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1209"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1252"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1280"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1407"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="92"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="800"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="765"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP15069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1436" mass="160376" checksum="34B54933388F0D85" modified="2017-04-12" version="1">MEGPNQQPSSPRGSIYVKDETESAATVLGDETPQKSSPSHSQHNDWSLLSRVQEQHERDMASGFKRQELGVTWQNLSVDVISAEAAVNENVLSQFNIPQHIKESRNKAPLRTILNKSHGCVKPGEMLLVLGRPGSGCSTLLKMLSNRRGGFKSVEGDVRFGSLTSEEASNYRGQIVMNTEEELFFPTLTVGQTMDFATRLKVPFSLPNGVDSAEAYQTEAKKFLMEAMGISHTEDTKVGNEYVRGVSGGERKRVSIIECLATRGSVFCWDNSTRGLDASTALEWTKAIRAMTDTLGLSTIVTLYQAGNGIYELFDKVLVLDEGEQVYYGPRDQARPFMEEAGFVCREGSNVADFLTGVTVPTERRIRDGFENRFPRNKDALRREYEKSPIHTEMLSEYSYPDSDIARQRTQDFKDGVTFETSKHLPKDSALTVSFPEQVKACVTRQYQIIWGDKATFIIKQVATLMQALIAGSLFYSAPDNSGGLFVKSGALFFSLLYNSLLAMSEVTDSFEGRPVLVKHKSFAMFHPAAFCIAQITADIPVLLFQVSMFSLVVYFMVGLTTSAGAFFTYWILVFVTTMVSQVLCVCSRYPLTFLQCMTALFRAIGALFSTFDGASKVSGFLISALIMYTGYMIQKPQMHPWFSWIFWIDPLAYGFEALLSNEFHNKIIPCVGTNLIPQGPGYTDSAHQSCAGVGGAIQGNTYVTGDQYLSSLSYSHAHLWRNFGINLAWWVLFVVVTIIATSRWKAPGESGSCLVIPRERLEQHNQNAPVDEESQVREKSKKPSAGDARDESNIDNQLVRNTSVFTWKNLSYTVKTPTGDRLLLDNIYGWVKPGMLGALMGSSGAGKTTLLDVLAQRKTEGTIKGSIMVDGRPLPVSFQRSAGYCEQLDVLEPFATVRESLEFSALLRQARDVPREEKLKYVDTIIDLLELHDLADTLIGRIGAGLSVEQRKRVTIGVELVSKPSILIFLDEPTSGLDGQSAYNTVRFLRKLADVGQAVLVTIHQPSAQLFAEFDTLLLLAKGGKTVYFGDIGDNGNTVKNYFGRYGAPCPSNTNPAEHMIDVVSGHLSQGRDWNQVWLESPEHQKATKELDQIIDTAAASPPGTFDDGQEFATSIWEQTKLVTTRMSTALFRNTDYVNNKFALHVGSAIFNGFSFWMIGDSIGDLQMRLFTIFNFIFVAPGVINQLQPLFLERRAIYEQREKKSKMYSWWAFVTALVVSEIPYLCICGVLYFVCWYWTIGADPSSSKSGATFFMMLLYEFVYTGIGQFVAAYAPNATFAALVNPLIIGTLVSFCGVLVPYAQIQEFWRYWIYWLNPFNYLMGGLLVFNLWDTEINCKESEFAIFDPPNGTTCINYLQDYMETIGARMNLVNPDAIEGCRVCEYTHGSDYLYNLNLKEYYYGWRDIGIVAIFAISSYALVYLLMKLRTKASKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SND0</accession>
    <name>A0A1Q5SND0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SND0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SND0"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="64026" checksum="882E761BD369B5BB" modified="2017-04-12" version="1">MGSELGITADTKAAIDLSPVSIWWVVWGCAWTAAVAAGMAYLIINRDMPTLRIRGLALSLSSIVLLHLYWWVCQFGTMVGALLPGDAQYWIMGTYLPCGIALFHASNTRFLHVAKLQRKYAQHGYRLVDAVPDQRPKTGLINRFRRLDYTTKILITVGIGMFLQVFLTVFNYVISRKWHSSWGIPGTEVHGSEMAQKTAQGQGWEWWPGVFWQFLWSWVLAPIILWKSRNIHDTQGWRVQTIGCALGSLHATPMWLIALYVPGMAPVNKYFIPPQWICLSIWIIEIFTVFLPCWEVMRHQSLRQETLDSIARWEIKVKSSNSENKSLNSETTMVESMMSGWKSTNASIKTTGSRDSILTMSALEHVLERNPTPLQEFSALREFSGENIAFLTSLAQWKNSLPIVLKDPTAPRDGNSKDLLREHFNLALHIYADFISVRLAEFPVNISSNDLKKLEDIFERPARLLYGEEREADPVSPFDKFNFEPASPTVSESSEKGMTNCIRNRVHYWGDIPEQFDATVFQDAEASIKYLVLTNTWPKFIKDRRTSIDSFDTMRTKTEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNF1</accession>
    <name>A0A1Q5SNF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNF1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="135" mass="14938" checksum="266CE5442451E39F" modified="2017-04-12" version="1">MLSSKTAPEIIETTQSCSAIEEMMLCPPSVATDSQVGYFPNEGKVYKIPFYMPIAPNIPASAATDLGNIYHNKGNVLRTSQEISFIRQQLIPDCITDIQQIRNYPNAAVEAQINLTQQIDSMEDSEICLDAKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQZ9</accession>
    <name>A0A1Q5SQZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQZ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="76" mass="8186" checksum="D0F6408915F30CCC" modified="2017-04-12" version="1">MPHTAPIIPVNAGRFDKGTDLGMIISALKKMPAPPIPATTRPIMWSTELGLAPQMAEPISKIIMAATKVHLIDNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SR72</accession>
    <name>A0A1Q5SR72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall protein phiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SR72"/>
    <dbReference type="OrthoDB" id="4093325at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012569923" evidence="1">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="182" mass="19067" checksum="BDD9FABD015648E9" modified="2017-04-12" version="1">MQIKNAIFAACLAATTTALPATQSNTFNLIAIHSASGVQYATFNAAKSSIFAGLASQNASCARPEEQVATFYLNNGALYLYDQSATPQELYVDRSGMGQGKIGYTTGAQSAPRNAEREGWAVKDGHLQFAGSDLIACPNSIENSWSIWAAAGVSNPAGNSDCVGIAARVEETSNPNGCLYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRN5</accession>
    <name>A0A1Q5SRN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Maltose permease MAL61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRN5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="528" mass="57218" checksum="36A057C8C7F1DCD2" modified="2017-04-12" version="1">MDASEHSRTDQDRTPIPDISHVPDHTQSPTENAPLFQEIQRYPKIVAYSFGLALAFLLTGYDTVILGTITAVPYFKKEFGERYNGSYIIPSAWLSVWSAIAPIGSMAGAAAAGWMQDRIGRRWSLAWSCVICAVGIAIAFCSYLPTAMDSRRSAFLVGRLIQGWGVGGAMAGAQTYLSETVPTSLRGSAMALSPTFMLLGELIGATVIFACEKKTSMAAYLLPFGTQWIFTLLPFILAIVLPESPSYLIRKGEYDQAHTAMKSLHGSHVDVTPLLAQLRVSIAHEQQLSNELSYLDCFKGINLRRTAIVSFAFMVPSLFGVPLLASASYFMQVVGMSSSTSIIVLILGIVLGLLGNGVGVWLMSRFGRRRPMLITLAITTALWTSMGIAGCWAGITVVWYTAACMMAVVVVCGMGAWPASFAVAGEASNLRLRAKTQGVGVLCYMLSNVVFNLVLPYIYNPDAGDLKGKTGFVYGGLCLFAFVVTWLTVPEMKGRTALEIDTMFESNLPCRQFKNWSADIVDPKAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSA7</accession>
    <name>A0A1Q5SSA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 15">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_13144</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 15"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSA7"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.40:FF:000002">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO90843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="607" mass="65917" checksum="3D0AF75B224E4A45" modified="2017-04-12" version="1">MAGDEPLLAPRRPSSDRSSIRNAEEEDALLTGERTARQPSRGWGFWGQVGTFAWAIIATILVIVLAVVYQHETAQNRRAPSKDVWGPGGKPTGKRNLIFMVSDGMGPTSLSMTRSFRQLTEGLPIDDILVLDKHHIGQSRTRSSNSLVTDSAAGATAFSCAHKSYNGAISVLPDHSPCGTVLEAAKLAGYHTGLVVTTRITDATPACFASHANLRQYEDSIAEQEAGEHPLGRVVDLILGGGRCHFLPNSTEGSCRGDDRDIVEIASQNGFHYLQDRAAFDALNGGTEAKLPLMGLFAEKDIPFEIDRRSQNDVYPSLEEMARTALTTLSEATRDSEQGFFLMIEGSRIDHAGHGNDPAAQVHEVIAFDKAFAAVLEFLEKDETPGVLVSTSDHETGGLAAARQLHTSYPEYLWLPRVLANAEHSSEYVAAKLSSHLAEAGKHDDDSKNKAYIRKTLLEKDLGITDATDEEVNSLLHPEAGVSPQYFFADMISRRAQIGWSTHGHSAADVNIYASSSKDAWPLVGNNENTDVGAFLANYLDLDVDAVTKRLQSAAYWTVSGEESTTQAKYNWMGNPLGSTVRTEGLDTYHGDFKKRSLDDCGCGAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSH8</accession>
    <name>A0A1Q5SSH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSH8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase (KR)" evidence="3">
        <location>
            <begin position="118"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO90825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="170" mass="18328" checksum="955B28027D644CCD" modified="2017-04-12" version="1">MAVLVPAQIRRRIYARYPRGGSAGILGIEKINISELVPFHDDPSRLFYILKQVSTLQLDQSIRRPSLKQVWSAPRSIEAIQWAQKPAQHVNGIITFHSDDRVPVTPGLANPLALDGDATYLLAGGTGGRGANLARFLARKGAKNLAIISRSGSSTASAESVFQDLTAKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVS8</accession>
    <name>A0A1Q5SVS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVS8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVS8"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29145" checksum="CB595ECD7128EB5A" modified="2017-04-12" version="1">MGQKPSVPRPGTKFQVIGAGLPRTGTASFSSALEILCDGPVFHCGTQATLGPTAQIKQWMEILRRWLAGSESDREIMFNVLRSQLDGYAAVTDSPGAQFVPELIQLYPDAKVICTIRDPGSWETSMDQVRNATVPWYLSLVLLPLPGLMWFIPYLRLLAAQWERLYGEAIPTRHTYERHIAWLKEVVPEDRLVFFEVKDGWKPLCEALGKEIPKDRPFPHINDSDAIDEISKTHVRRGLARWGVILAVGAATVAWILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWG0</accession>
    <name>A0A1Q5SWG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWG0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="507" mass="57901" checksum="DEBF425B04ECC0A0" modified="2017-04-12" version="1">MVDPVSIVTLCELCLKHARGDIAKQILRVKNYWMRANLQLEIIKHIVHELRKDHRKIIYETINMLNNSLTAAEMNIESTMKKKECDGVEAQVSRFKYMLARQSIDKSVDELERWHHMFDPSWYLAISRATSGVESELFKWKVSEIEDCRVAISSAETLRSALRIASNAEGPRERVLLPEAFLEGLGAQDIPLSSAQLGTREDKGQMLILEKVEPLPGLNVTDLDKNCRDLARRLTKSNPLEFGLLSCKGYMKHRHQPSNRAEGDSFTLLFRVPSRFFQPRTLRSRLMKLKPTDSLTDRFNLANELARAVSCVHAFGFVHKNIRPETILLLTNAESCTESAFLIGFDSFRMASGKTLRKGEISWERCLYQHPNRIGNSASEDYIMQHDIYSLGVCLLEIGLWEPLVTYEDENMPLPRNGTSPPALRASFLEEGRDSYIFKDQLLSLARGELQRRMGTRYSEVVVTCLTCLDPENEDFGDEAEFQDEDGIEVGVRYIEKVTMRLNSVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SX76</accession>
    <name>A0A1Q5SX76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SX76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SX76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54503" checksum="C62CA6A6FFBC96B2" modified="2017-04-12" version="1">MNDDVLRAVRCDRRLHCSNCADAGAECRRLRLERPARSQKPTVIENSSPAHGAYKNEIDVQPKKRKLDHVVSAKETPKSPLSNCPVVTPDESTHHAEQARVIIQSELDGNERMNRERRVILKSALEFVNSMAQRTDSASDDSLALEGSHNDCPDIPESIEPSPELLYMLIRGTDSKIHSHTIIFTSGIVTNERAESTTSTEPSHNLHWPDHISNKALQKMASKFFTSNLTGQRFYQYCICIYMRAIFHTYHMPRLYNDSVMSEQFLKSKRLYAASALHALQNLNILNTPSLSLIQALISATFLMQYLGNMSQAWVLNSYAARLIAALNYHDVQSQNPFFVLFCNIIGEIDMDDYHLIQDITQSLSLFNASPYIAKLLKLLDTLQQLCEPLILTKQHLGPQAKVAPWYPATSDEQPATMAVSDASVALDASYMNSMAQTYPQSVQQDASGGVQPVADELMWHLFNSQPSLQWCESNVISLDPTVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXX9</accession>
    <name>A0A1Q5SXX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bactericidal permeability-increasing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXX9"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="595"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="95426" checksum="7E48276313CFB84E" modified="2017-04-12" version="1">MSSKAVNVPTDLKQKEKDINSKLQLFGIYHAFKNNKLPSNKQCDVALNSALSSKALSSPSNELSSEGKVLIQDLRNVIEQAKLLLLTKNEGELLQDFIWQAQQINTGDVQAPNVPISKETGQQDANKALEGLKTLGTLLITNGEFRKILSDAMVLIRDMAADASQKAANVVRPPEEHLSQIDEPAEENTWHEKPSVSKEDIKQRLKRKGDKDGVAAPSIPETEYTDEDGASVTPSEQSRRKKYGQQAKEYLSEKVPKERREQAIWRLKKMVIEIQGHADYQQAIETLLSMAEKYAGHTKSATTQSGGAVRDIRSTSRVHTVEHNLRTLIERFANNTSLSDFFESLNNIYRDADKDPELRGWFSNVDTYIRKCLREQGFIMQDESTRQWNELYDRGRYLLRERYRTHTDRIVDETKFLADQFDKDPRNKAFADSIQKLFLDLGRDAGGKVVFKKHLLKDIRDVILPGIIENVRYIPIPRIEVSDPTVDVVVENLTVESDNLMPNVVEFGSDNYFRWGRKKISNKRDNKIMIAASGIQADLRDVSYYIKKKQGFPSITDIGVMDIILGGEGFGFKIAASTANKEDKQHFVKLDKVSVNIKNMDIKLKKSKHKLLFATFKPLLFKVVRPALEKVIEAQIRQAFTDGDAYAHEIHKEALRAQEAAREDPENAPSILSRYADAMRARAQAKAKKAEAIVSRTKVQTVMTLHDSIFPDIKLPGGISSKATEYAELAAKGEKWESPIFSIGDASESKNIPSAGDVTRKPHTTATDRAGPAGAAGAAGAAAAGGIATTGVATTTGGATTLPGTNGATKVDGYPSRGFSDELDEAFVGDKTNALGAGVKPATNGTNGTTRNGTTHVTNGSAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ96</accession>
    <name>A0A1Q5SZ96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ96"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="57"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO93272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="23060" checksum="5F491DA13A5DD55D" modified="2017-04-12" version="1">MSDSGDVQAVQLPKEIAHLDNQPVLLFGKWSYEDVEIRDISLTDYIQIRQPVYTSHSAGRYAAKRFRKAQCPIIERLTNSIMMNGRNNGKKAMAVRIVAHAFEIINITTDSNPIQIAVDAIVNCGAREDSTRIGSAGTVRRQAVDVSPLRRVNTAIALITIGARESSFRSVKSISECLAEELVNAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T121</accession>
    <name>A0A1Q5T121_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Granaticin polyketide synthase putative ketoacyl reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T121"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T121"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="251" mass="26572" checksum="11686EFFDDD509F8" modified="2017-04-12" version="1">MPYSLKGRNVLITGGSRGLGAVIAQRFAAEGSNVAINYASSKETADKVASELAAQYNVKTITVQGDAGSQSDCTNVVKTTIEQLGGIDVVISNAGWTKMTKFSDLDAMDDADWDKCWSINVKSNFHLFKAALPTFNANPDGGVFILTSSTAGVTPSGSSIPYAVTKSASIHLMKCLAQSQGPKVRVNAVCPGLLLTEWGKRFSPEQIKGWEDRTALGHTPEVEDTADAYLSIARNSSMTGQAVQVGMSIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2L1</accession>
    <name>A0A1Q5T2L1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">PENSUB_11747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2L1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2L1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO94480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="60" mass="6424" checksum="C3700856265883FE" modified="2017-04-12" version="1">MKGDKEFSGTLLGFDDYVNMVLEDVTEFDYSGAQIKLPKLLLNGNNICMLIPGGEGPGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4N3</accession>
    <name>A0A1Q5T4N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4N3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4N3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF52">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="10779" checksum="DD1D5D589E549F8B" modified="2017-04-12" version="1">MVLDNKLELEHIHVDDVGGGDSPVIYTAAKELKVVRNTIMYLGALNTGYATSFFTPSILRDMGWTSLMAQVMSIPIYVVAAIMTLCTAILSQETKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5V0</accession>
    <name>A0A1Q5T5V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADP-dependent 3-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5V0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5V0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="32"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO95617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="32418" checksum="94E50457279821F8" modified="2017-04-12" version="1">MAAPFPSPTSTWHSTTYQSLSPTRPELSAKGKTVLITGGGTGIGAETAVYFAEAGASRIALLGRREKPLVDTKALLEQRYPNLEVYIAPTDVTNKKQVDAAFEDFIRNSKLHVLVSNAATIGPQDSVEDVESEAFIASIDQNLKGSLLIAQAFLRYASDDAVVIETNSSAAHLNFGPKFAAYSIAKFGVYRLWDAVAFTRPNLSIFHVQPGVVDTDMNKEAGGVAALGFEDHVSLPASFYVWLASPEARFLKGKFLWANWDVDELKAKAKEIESGSLLAIGLVGWPFRQDDWELSANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Q5</accession>
    <name>A0A1Q5T6Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U3 small nucleolar RNA-associated protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Q5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Q5"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO95903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68482" checksum="A1A625FB83489F53" modified="2017-04-12" version="1">MSSAGLKTETKRVSARSPFENTTPQTHSAVEDIDMDDETSSDEESIPEKGEDELKLERMLFGDDEGFMGALKAQQEREGGMQLTLHSDAESASADEEDDEEGDLNNMADADLFFLDSGDVQTTTDLIESPETPSDEEQEEESAPAIWHDSDDERIAVSLVSQSKLRKLRNTESEDIISGTEYIRRLRRQFQRMNPTPEWADPELASKRRKTDSDDSDVDRDEDMESDEDEQLAAQPLAKLLQNTTELTRIEDNTKSGSKRKLRQEVVDIQRLKDVGKTQPSSIDSLMFHPHYPLLLSSGPASTLFLHHISPSAPSPNPLLTSLHIKHTPLHTSAFAPPSGNRIFAAGRRRYFHIWDLDTGKVDKVNGSADRKEEQKSMERFKVSPCGRYVGLVGTSRKGGGMINVLDSGTAQWIAQVRVDGRGGVADFAWWSNGEGMTVASKNGEVSEWDGRQRRIIARWLDAGAVGNTVIALGGQSGRDQLGGDRWVAIGSTSGIVNIYDRREWAAAAAAGAKSNVPVQDDSTQAGVPRSPTPTRVFDQLTTPVSHLVFAPDGQMMVMASRWKRDALRLVHLPSCTVYRNWPTSNTPLGRISSVAISPNNEQLAVANEQGRIRLFEIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6S1</accession>
    <name>A0A1Q5T6S1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6S1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="33816" checksum="3BD1E74BF410949A" modified="2017-04-12" version="1">MNIPGSGGMFFHQVSAILELQKIFSVNEDTDLSASEYFVVCLYRVLLRDFNDIPDTGEAEWIRFGFCYCTTRSQRELLAHHYIQLASHASLNQIAEAWKSDELLELMATKDIDTSSLLSHGIYPRRPSPETIGIYRLMSEVTHILNGCAICPCNSFSCQFHSKEEPSLCLESEIDYGFHETNTWERWQLLNFYSSLFKNPKFHPRELQKARRDPDTKVFEAYIESLVPGFRRALINEHLTDAMFPKFARMEFKGEHPFCNCAIHSMVVSEGTNLGPIGYFRQMRDERNREQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6T6</accession>
    <name>A0A1Q5T6T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_10988</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6T6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6T6"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="783"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO95967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="858" mass="95842" checksum="24350CAD601771D8" modified="2017-04-12" version="1">MFVYKRDGRKERVQFDKITARVSRLCYGLDPDHVDAAAITQKVISGVYQGVNTIELDNLAAETAAYMTVTHPDYAILAARIAVSNLHKQTRKQFSMVIEDLYNYVNPKNNKPAPMISTEIYEIVQKHAEELNSAIVYDRDFNYNYFGFKTLERSYLLRINGSIAERPQHLLMRVAVGIHGNDIEKAIETYNLMSQKYFTHASPTLFNAATPQPQLASCFLVDMKEDSIEGIYDTLKTCAMISKTAGGIGLNVHRIRATNSYIAGTNGSSNGIVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFYALWTPDLFMKRVEANGDWTLFCPHEAPGLADVYGDEFDALYERYEKEGRGRKTIKAQKLWYAILEAQTETGNPFMLYKDACNKKSNQKNLGTIRSSNLCTEIVEYSAPDEVAVCNLASLALPTFVDAARGEYDFGKLHEVVQVLVRNLNKIIDINYYPVPEAKKSNFRHRPIALGVNGLADAFLALRLPFDSPEAKQLNIQIFETIYHGALTASAEIAAKLGPYETYPGSPVSQGILQYDMWDRTPTDLWDWASLKARIAEVGVRNSLLVAPMPTASTSQILGFNECFEPYTSNIYSRRVLAGEFQVVNPWLLKDLVDLGLWSDNMKNRIIADGGSVQNIPNIPADIKALYKTVWEISQRSILQMAADRGAFIDQSQSLNIHMKEPTMGKITSMHFAGWKMGLKTGMYYLRTMAASAPIQFTVDQEQLKVEDTNVARANAAYKKRAVGAAGSAYSAVPRSSSSEDAIPTPSAESPRTPAPTAPIVVPIVQSEESTEPETEGKSEEDIFSDKVLQCSIENKEACVMCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6V3</accession>
    <name>A0A1Q5T6V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10982</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6V3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6V3"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="197" mass="20919" checksum="789106C89FE48889" modified="2017-04-12" version="1">MFKRLVTVAPRVGVAAPRAFAPLAGLQSVQPTIQRQTPAPTQRRSYHEKVLDHYNNPRNVGSMKKGDQDVGTGLVGAPACGDVMKLQIRVNKESGRIDDVVFKTFGCGSAIASSSYLTELVRGMTLEEAGKVKNTDVAKELCLPPVKLHCSMLAEDAIKSAISDYYTKNPKARSTDLSGTGASMADIPTAGSPAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6V5</accession>
    <name>A0A1Q5T6V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6V5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16061" checksum="8B8C07C9E50F8417" modified="2017-04-12" version="1">MPKNAMYRMHTEPSSGLVVAGSKRGEPCTIQADHQARKTGMSYRQILCMVHGAWCMAHGAWQAGKREMRKRDIKEPRGGPNDPRVTDGEVKQTIRTTLDYCPGVVQVFWEKQAYLSHPAQTNGVVTTSTIDESEVDDGAREAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9F3</accession>
    <name>A0A1Q5T9F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9F3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9F3"/>
    <dbReference type="OrthoDB" id="4349001at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012163085" evidence="1">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="11137" checksum="19973F908B989311" modified="2017-04-12" version="1">MKPSTLFLAALAPAAVLADPLPRANVNLAHNADTLAQRSPFATIPEPHRYHTRSSADSEVQVVTLDKRVARHILQARSEGSLGQTPWIGMAIGLTCTALAAVMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9H6</accession>
    <name>A0A1Q5T9H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9H6"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="12135" checksum="2EC9C0813A7556F4" modified="2017-04-12" version="1">MSFLTSVRTGSRRVLPSSYTLPSISTFHTSTPRCGLKESDKNRDDLPSHYETQKDQQLKSQKTGTAKWNSDLASNSEADVKADRGEVDSSDKAFQELQQKTKQIPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAQ3</accession>
    <name>A0A1Q5TAQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAQ3"/>
    <dbReference type="OrthoDB" id="4450707at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="115" mass="13598" checksum="4508A2BBAEAB2655" modified="2017-04-12" version="1">MAGCTVKTFFKEAREFYQNAEADGGMALHLKMPSLLQERYMQESFEEEFDILCEEVMKLVLIDQKDRIVEVSLQRNIKIEEVEIEQVKMEEVKVEDVKVEEMKIEQVRIEEKGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAW5</accession>
    <name>A0A1Q5TAW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAW5"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000218">
        <property type="entry name" value="Dihydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="286" mass="31002" checksum="9546EA27A5E222BC" modified="2017-04-12" version="1">MAPNPSASARQPLKILMLHGYTQSGPLFHAKSRALVKHIQKAFPLHEVSAIYPTGPLRLKPSDIPGYEPSEGGEAEDDEIEAYGWFRRSNTANPPLYQGLEDGLAAVAKVLSEEGPFDGVIGFSQGAAMVGMVAGLLETGRKEAFAKFEKDESEGAAGIPYPSSFAADGFQHPPFKFAIAYSGFRSPGARYRGFYESPPVQTPVLHVLGSLDAVVEESRSRSLIDACAGEPEKDGLVVWHPGGHFLPSQRPYLDAAVRFIREQLEKSNGGKKADEEQDVNDMDVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBU7</accession>
    <name>A0A1Q5TBU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heavy metal tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBU7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="4">
        <location>
            <begin position="83"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO97650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="191" mass="21106" checksum="6E3AF610AC10CCD8" modified="2017-04-12" version="1">MQNRVAGNPAFGSHRASVILTPCSSDDDPGNAAAEAPGSGDLAGYPELPFLPRAWKYVMGYKVFFLYMWPSGSRYLQVMAVVCLCLTGCQRAVNALLPYQIAVVTETLSPSSSELPCFHILKFVIYKWLQGGNGFLGSLRSTLWNEVKESSSMKLSIAAFKHVHSLDLDFHLDKRNGEILSVLRNDNPTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBW3</accession>
    <name>A0A1Q5TBW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000687">
        <property type="protein sequence ID" value="OKO97719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBW3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="13446" checksum="A79B570EEF41C984" modified="2017-04-12" version="1">MSLTYTVDDFIFSWDDANDPLPCWQCLLEIAQPNIFLYQASFNICDVASGHPYPCSECVQYHLRCQTIPMVLRPEIWYLLYGNHAFSDQQIRERLSEILQPYRERHQQLGDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC19</accession>
    <name>A0A1Q5TC19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC19"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC19"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="17722" checksum="25B91EDDEEC0FA1B" modified="2017-04-12" version="1">MAHSGPLPVLVIVSQRSSLYAKTKTAPEEIVPLAMRLLKKRNMWKATDHSTPTKLLAVQKLRSRAFLVFDIANEAYDAKLGRLPKHNQLPVVLAHFSKKKAAYPANSWVSQQVNHDVAMLHNANGFGYVPPFKEDHTLGTPPAYHSPRDISMLRVTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC76</accession>
    <name>A0A1Q5TC76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sphingolipid C4-hydroxylase SUR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC76"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="204"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="421" mass="47423" checksum="EEC1D3C3C67ABA04" modified="2017-04-12" version="1">MAVNASVAFDLPPLPTYTLSVREPLLPPIPDNVLALILPIIAYWGMSMIYHFIDVNGYFEKYRLHTPAEVLKRNKVTRWEVVRDVILQQVIQTIAGYGMSYFDAVETVGREEYDVAVWATRLRLLQKAIPPTLALVGVDAVGLAKSVSQNGTMLAGALAGGSYPDVVQSLILDSGAEVVAPAFAGWELAVASFMYWYFVPALQFLLAISIVDTWQYFLHRAMHLNRWLYVTFHSRHHRLYVPYAFGALYNHPVEGFLLDTAGTGIGFLVSGMTNRQAMWFFTCSTIKTVDDHCGYAFPWDPLQHFTSNNAAYHDIHHQSWGIKTNFSQPFFIFWDRLLNTQWKGEVKLRYERARESAQKQVDMDAAQAKAAAPAVPIIEEREHERVVVSPEGPATRTRLRRKTVDSLKGPSHGVPGSVLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC78</accession>
    <name>A0A1Q5TC78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthetase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TC78"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="793"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1325" mass="146215" checksum="7CB9DE12D006D43C" modified="2017-04-12" version="1">MQASKTVILAERVSDCGRPKPLVESLSFLSTGSNKQISSAKNMNRLTVDAILEPSSQTVLLQLCWAAVLARYAETPDIQYAYVLEDSEEVRLFHSQISSGQDVYDALESAAYVTSPLGLIGDSLSQEAISSQTGNLAFGTILLVKGKNSPSRISLTKELFTGTALLLECAVAAQHVQVEWTCRKPLAPEYVYMIMTQFAHALRVSTKSRKENIRYRDLQEISPEGFSQIIEWNGGREYVTRETFAHHLFEKMVIKQPHAPAICAWDGDMTYGELDSYAEFVASQIMASCQIEHEGVLGLFFAKSKWTAVAMLGALKAGRGFIMFHTSQPPTRLRTICERLGVLAVLSLPGFKTALDELDVPKIILSTDKDEGFLPNTASQKPAPLPSESNSILYAGFTSGSTGEPKIFDVRHSAFCSGISAWGVAMNVNERSRVFQSASYNFTVSVIEQLAPLCLGGCVCVPSEEALQNDIPGAIRDLGANWAEFTPSLARLLDPSTLSGVKTLVLTGEALARADVEKWHCHLDLRVYYGQSEHSLGATVGNTADLVADHRNIGRTFSAREWIVDPEDHNRLAPLGAEGELLLEGPCVGVGYLNNPKETDAIFVRNPAWFLSQRLTPVTDGRFLKTGDLVCYDMHRGCLQYRGRRGTQVKIRGQRVDLGEVEYHAGKHLSSAQGKPVAEVICPKVYAQKSDPVMVVFLVTDTPVEMAVTSYEDFDSPIIFPPNDKLRAQAKAALARMKDVLPDYMMPSAVIPISHLPRTPSGKLFRRRLRDIGSQLALDEIVAYVNLRKPHQAPETANEEKLQQISASILGCSASQIGMNDTFLELGGDSLKVRHLVQAARTEGVTLSVGDIFKNLTLADLARIAQEGPMSVPAHEKQPEEPVVKSFLQSKPEFAIGSRIESVSRTHDIVKATGNENAVEYFLFSLYGPLDVERLDVACQALVACHAVLRSVFIPYEEEIMQVTFRSLKASFEVIEASPGVDPKVLTDRLCHEDKMQSPFGPTPVMAFTVVRSSPDNHILVLRLSEAQCDAHSLKRLISNLMLLYDETSIHVQLDYRDYLAICASQRTPEAFAYWRTLLKGATPLHLDSIRLNTQSSWMCHGQLTGKTYHHDSPPSLTFSRTIPPVTARRGITLATTIKAAWSYVLYKKLHCNDILFGQLGSCRTMNVPGIEDTIGPCTNVTPVRVKYVPQWDPSEILQTIQEQHAQSLPYQTIGWRDIVNHCTTWPDGASLQTVVLHQGEQEDTEIQTRGGLKCRALDWSASSILGRLYLMTESTSSGLNIELCVPRGAIDNSEAEGLFDLFCSAIGTFCSWKNRDSHATSRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCC5</accession>
    <name>A0A1Q5TCC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutathione transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="50486" checksum="AEE118AEE15BCCE9" modified="2017-04-12" version="1">MADAKEIDVHEKHASGSPTVGYCYNTWKISRYAFFTITCCISFCWYWFPDFIFPALSYFNFPCWINPTSSVVNPLFGMKSGMGLIPITFDCMHFINMGVYDNTRGIYKVSKIVNKASGYTLDLQKYLACSPVYMPITYALNMFGLSFATLSTLLVWVTLEHRQSMLDAARRVPQMLMESLPGRSKPQGYHETGAPDVPIWWYLVGCALALFMSIFAVEYWDAELRWYGVLLACAVALVSTLEIVSGSVFEGKVLANIWFFDIGYITTIKGLYFAHDMKLAYYCKIPQRKLFLVQCVGTLSSLGVLNWALNHISGVCTSAAVNGFRCPFSSTPFNTSLIWGAVGPRRYFSNHIGYHALLYFFIIGAILPYSCLLPESPRVHGWWSKYNFVLSSALDPSVGIAGVFIFLTIYFTGASERFSWWGTDVYQNTCDWKGCPYLSVPKGVKFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCC6</accession>
    <name>A0A1Q5TCC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCC6"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="113"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="29381" checksum="B31AEC36FE89DB67" modified="2017-04-12" version="1">MTDNNKGCKITLYWLEQSRSHRILWLLEELQLKYELKTFKRRADKLAPRELKDVHALGKSPVITIEAPGSEKPLVLAESGAIVEYLCDHFGSARPTLVPERYQAGREGQVGGEREEWMRYRYFMHYVEGSLMPFLVMTLVNDTIRNSPPFFVRPITSIVASQVESAFLTHNIEGNLSFLEQQLQTAPEGGPYLCGKELTAADILMSFPIIAASGRILKDQKQKDKYPLLAAYAQRLEGAEGYKKAVAKIEQIEGHFSASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TER1</accession>
    <name>A0A1Q5TER1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TER1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TER1"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="252" mass="27673" checksum="7BF82CC34479429E" modified="2017-04-12" version="1">MHIILTGATGLVGSAALVALRARPDISKISILSRRPVPMLEGNNDDRIQVILHDFKGYDNALKERLRDAQGVVWALGISQTAVSKEEYIHITKTMTLEAAKVFEQLKSDEPDNFRFVFVSGEGATPEPGRFTPIFGRVKGETEIALMEMEAKNPKFQAMIVRPAYVDPKDHQVIHPWIPQLSLARRWGDSVLGPLARGLWKGMHSPTGPLGEFLAGLPVGAFDGKLKGEGVEMHGSSVLVNNVGFRRIMGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEX0</accession>
    <name>A0A1Q5TEX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="51"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="334" mass="35589" checksum="12E0A4F826E04481" modified="2017-04-12" version="1">MYALEQERAHPVPPPPPPLSMDRISGPSAGYPTPGTGPLRSSDHLAPISTSHEGRIWSLQVVQQPIRARMCGFGDKVGGSSSQGEIDTSFYVLTVDLWNADGTNEVNLVKHSATSPSISTAMSSSYPPPPQSMSPTYPAYSQNAYGQPVGYPPMSNYYGQQQMYQNPYGQAVGYPPYGYPQGGQMPAAMSPAPPVSGGPGGMFTRNLIGSLSASAFRLTDPDNKIGVWFILQDLSVRTEGTFRLKMSFVNVGTQSTESSNGAPVINHGSAPVLASVFSEPFQVFSAKKFPGVIESTQLSKCFALQGIKIPIRKDGVKGPRGRGGDGDDDDGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEZ3</accession>
    <name>A0A1Q5TEZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEZ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEZ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="100"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="338" mass="36881" checksum="54DE3BD731B196BA" modified="2017-04-12" version="1">MSVPGVNQPPYPLHDSVKHLLDPEYVDFYNQHVINNQQVHLQPVAASRTSGVLIPGAGPMLEVGKTQDITVQRQATEGPSVPIRAFTPTGEVPAGGWPVMLYFHGGGWVLGNIDTENVVCSNLCVRGNCVVVTVDYRLAPENPFPAAVHDCWEALLWLVQQGPSALSINPSRIATGGSSAGGNLAAIMTHKALTLSPPVHFKAQLLSVPVTDNTALVSNNESYRQYEHTPALPALKMIWYRDHYLPNEVDRTNPEASPLFYTGDWAQLPPALVMVGELDVLRTEGEQYAEKLQKAGVEVDLQVMKGMPHPFLAMDGVLSEGKRCITLMCDALQKAFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFE5</accession>
    <name>A0A1Q5TFE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_8865</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFE5"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000025">
        <property type="entry name" value="Pyruvate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="212"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="411"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO98948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="569" mass="62899" checksum="240EA80C8801737D" modified="2017-04-12" version="1">MTSTDIATRELENPMDLTEYLFRRLHEVGIRAVHGVPGDYNLSALDYLPKCGLDWVGNCNELNAGYAADGYARVKGISALITTFGVGELSALNAIAGAYSEFVPIVHIVGQPTTRSQKDGMLLHHTLGNGDFNVFNKMSAAISCYVAHLNDPRDAATLVDSAIRECWIRSRPVYVTLPTDMIAAKVNGDRLNQPIDLSLPENDPEKEDYVVDVVLKYLHAAKNPVILVDACTIRHRALKEVQQLVEVSGLPTFVAPMGKGAVNESYKNFGGVYAGNGSNAGVREVVESSDLILSIGAIKSDFNTTGFTYRIGQLNTIDFHSNYVRVRYSEYPDVNMKGVLRKVVERMGKLNLSSIPQIHNKIPASEQNSNQTINHAWLWPTVGQWLREKDIVITETGTANFGIWETRFPAHVTAISQVLWGSIGYSMGACQGAALAAKEQQNRRTILFIGDGSTQLTVQEISTMLRNKLNPIIFVICNEGYTIERYIHGWEAGYNDIQPWDYANIPKVFGGAEGYKSYRIKTRDELKNLFADKDFSSPSNLQLVELYMPRDDAPAALKLTAEAAAARNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFU1</accession>
    <name>A0A1Q5TFU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein ypt2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_8468</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFU1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO99082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="205" mass="22690" checksum="463F9D7646900D51" modified="2017-04-12" version="1">MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFQNIRTWFSNVEQHASEGVHKILIGNKCDWEEKRAVSTEQGQQLADELGIPFLEVSAKNNINIEKAFYSLASDIKKGMDTSKTDNGSSPGLHVDQGSGQNASAGGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFV7</accession>
    <name>A0A1Q5TFV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_8505</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFV7"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO99119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="444" mass="47860" checksum="3D5253FA40CABD42" modified="2017-04-12" version="1">MFKLARGRPIAAALRAATESSVSSRLAQQQKRNLSIHEYLSARLLKQYGVGVPKGEVASTAEEAEKVAKSIGNDDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPAEAKIFAHEMIGHKLVTKQTGAAGRLCNSVYICERKFARREFYLAILMDRGTQSPVIVASSQGGMDIETVAKENPDAIITTPIDIHTGVTDEIARTIATDLGFSEQCIEEAKTTIQNLYKVFMDKDATQIEINPLSETSDHQVLAMDAKLGFDDNAEFRQKEVFSWRDVTQEDADEVKAAEFGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGSPANFLDVGGGATPAAIKSAFELITSDPKVSAIFVNIFGGIVRCDAIAQGLINVVQDMGLRTPIVARLQGTNMEQAHKLINESGLKIFSIEDLQNAAEKSVQFSKVVKMAREIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH49</accession>
    <name>A0A1Q5TH49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH49"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH49"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="135" mass="15262" checksum="52C874D660479D25" modified="2017-04-12" version="1">MDANLLRTPSAEHTTESDDQISTSSDSIQKMKRTRSIETWISDRFVWETLAISASVNLVVAILIILMRFESQPTWKYVSLNSLISWLSTFSKACLLFAVSETLGQLKWVRFASKSRPIQDLRTFDAASRGHYGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIH0</accession>
    <name>A0A1Q5TIH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIH0"/>
    <dbReference type="OrthoDB" id="4495044at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="499" mass="56569" checksum="6AC767A77E0C9D6C" modified="2017-04-12" version="1">MNLPTKDTPHLLISFLLTATISNIIKPSGRQTFIEDVKHNILSFSPFRSLRMVSSFVIYLLHLRLLNIAEIKTGLKLVSHVEFSSDSSDLRRGVWPRFARRVFLIGVTLSLYAILLASSSYQWLHVVMALFVAEPVLAELLWLYRDSSHDGFLVQRGWPRCTMLVSAADYRVHDHADNPAKENVTGQDKDNRDLAQPSLLKDNLCDRIQQLWSKNSDPDIHFVASSLNPELDSKLERILSLNIRPAKWTCGHWRCLVYIISRIALRIMSLAWYIEQALITRLLHTDIHPVMLQLSQKILKDNVLGGLLTYAYQISCVLTPIFSAHFFSRLLFILLYKQQRIRQASQDFARFAPITYKGMQVFGQLFMPNILGFVLARTISSQCILLTGEKLSYALEIPLIIIIYITGYRLLFSVPHTSTKREPCYDSISSLEPNSASKSETQGIANSAASVSPQTSFDDKMKAPPGGSEYPRVAASSCFQIFRLAISVPTVAFWIFNHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJK6</accession>
    <name>A0A1Q5TJK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJK6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="523" mass="58455" checksum="ED54F110CADA4511" modified="2017-04-12" version="1">MIEAHEEDLKTYIYRELEQGGKYDIADQSFMNRLVRELTKGAEGMFLLPVLRLRTILKEPTPGQMEDRLADLSHSLDDAFADTIARIQRLPESRSRLGLDALRWLTLTTEAMTESELSDALAIHEKQNAVNVKYRPTTKTILECCQGLATVDTEGRVRLAHYAIQEYLTEHSEDLFPRAEATIAVTCLRYFVFENFQDGPWTDRSEIKSKMEMYPFLAWAARHWGHFTQQTETDPEVWSALFTFFSSSVATAVTNQVRQYSLGLRRDYWIASECWSYTALHHASREGLDRAVNQLLDSGAFSVNELTEMGATPVLMAAADGHTLTTRSLLAHGANPRLRNWYGDALDCAIEADRVDTIRELVRWGMDPNGVADDGHTYLNSALDTDSAGAFATLVELGADIEAQSEKEHHVHIFLTAARWGCVKIVSLMLMRGWADIEMRSPSGLTALHYAAAAGETTTVKRLLDASADIKAMDKKGRTALEYAEARGNKTTARLLVDAGALPRGANRARNLVLRSDRPAATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJL6</accession>
    <name>A0A1Q5TJL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJL6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012095401" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="96" mass="10170" checksum="41DE8DA7CFDB5C3E" modified="2017-04-12" version="1">MQLSSLLIGTLFALGLHAAPVADDAGQSEVVDGKKLFERSGQLCRVLSEHVNCRSGPGTNYDIKVGLSSSWTRGYYFTCVKSGECVTLNGAVNCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJN9</accession>
    <name>A0A1Q5TJN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJN9"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067145" description="Fungal N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13869" checksum="6E0312D4425D4997" modified="2017-04-12" version="1">MDGLSAGASVIAVISLAAQLGAGAHTLIKFLNTVSDAPAEIQRLESLLDQIYAIATCVRNALEYQRKLHGEEHILADDVHISLLNCRKKVQGIEHILSIDSKKPRKVAQWSVGNGRRQVGFEGGCAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJU7</accession>
    <name>A0A1Q5TJU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJU7"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23210" checksum="9ED62ACB42CEE57F" modified="2017-04-12" version="1">MIGSIFFIFNRMVEITFLIPIIGIMAYFVNGYLKANMLTPPYILVLFIVSVIAVFWCIDTLIRFSATKRSSFFVSFLDMCFFGAFIAGVYQLRFIANADCSHWDGGSVWVSLGPFGEYGRQVNNPLAFQVNKTCAMLKTTFALGIMEVVFFIWTAFLALFIHSKNREVIVKETTVRRRSHSSRRGHSSSHRHRSSSRRPSYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKX2</accession>
    <name>A0A1Q5TKX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKX2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKX2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="90" mass="10453" checksum="3CFA4B67ADB970C2" modified="2017-04-12" version="1">MFAMRSAPSNTEIAQICLVYLLEPSLYRELSEEEDLTEHPFARFAAKHWFHHYSNSNEGKSEIEPLVLRLFKDNPYSFAAWIGIHGIDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKY7</accession>
    <name>A0A1Q5TKY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAC3 family protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SAC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKY7"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000008">
        <property type="entry name" value="Nuclear mRNA export protein SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="6">
        <location>
            <begin position="100"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133864" checksum="584B40330055BA56" modified="2017-04-12" version="1">MAPGAAMRGGAAARNNTFNPGAPQDISRQSPTVNGHSPSTKPTSADHTTMSGSYQDRYEQLKLDRAKQRQRAIRDGQMADPNQPTSLKKAIRPVGTCASMCPEFERVERIVQKMVDRSEKHLDPATNTLQNMEAKMLKRFRRSAAGYDEQLPSDIRTPKALLQSTNYLIRYVVGGNETLGIVHKFVWDRTRSIRNDFSVQQVTHEADVKVAVLCLERIARFHILSLHLLSSPANEEQFDRHQEREQLNNTMLSLMYYYDDNRGRVHFPNEEEFRAYYIIFSIHDQRPDLEARVQKWPAVLLNSPRVQVALELYAAACNTWEYQGTLDARRPNAIAQGFYTRFFHIIDSPSVSYLMACVAEIYFNHLRQTTIRAIWKAYCRAPVSQQHKNEEWTVEQLTKVLYLDDDEQTIKFCEDQDLQFAENANGDMYLNWGNRPVDSVGFSPSSEHAFSETYVESKRAGRNLVAVILGMSVREAAAMGMIDESEVPERMQESPMQASTPIENTLFVSDKENTTPAPTVEIVPTSLDSDVSLSASPTKNAFNPFQQQKPTPSPSPSPFAIPTQSPQPAAPELATQPPNPFSSMFSGTPSKPVESAPVNPFAPKPVSSPSPFAFPKPAEATQPAAVSTAPSIEFPKPAATEVAQEGTPPIPSPFSFPKPAETGVKAGTPPATSPFTFPKPTATTEKKTTPAASPNPFAASLSNFAPPKPFESAEEAAPSGIGKSPFPTPGANVTTSKAPEVSTTAPSLFKPAFPQPSTSTTPFPSTSSPFTFPSTTPPVSETPPTVTEASSIQETSTFFESAKPSPFSGFPQKSLFQPPEAPAAEEKKIEDAKETSVPVSQPSQLPTTAPSATPKLFGSTAGPSVFSTLQNQKPLFPAPSSLASQDAVAEPSPIQGKESVFAKPAKPRKDEAVLQKLPPIKVAAKSPEPVEPALTVSQLEQSRSSLSSTQSSVDSESLQWRAPQTEEEEAALFKRIMRRAEDKAQRKEDKLKRKRVREEQALEDSTREERLKVSKVSTPEESPPPAKKFSLADSSIKALPTLPCLEKAKALLEKKSATAADTETETRKKRQREIDEDEMLLNSARIVAEQLRTGPKLFDDVSPQTLAEHNAYHAYWEERGKRARSYSNSISPSITPYAQSASPPQFPRHSYEVAYAPDTPQGLGRTMSRTEYRIRMTGGHGLAYKPLDFSRSNSRGKDKLQDNEKDKGKSRFAMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLE9</accession>
    <name>A0A1Q5TLE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLE9"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP01061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="461" mass="52090" checksum="D90D6BFD8E401005" modified="2017-04-12" version="1">MADPTSPAPAGKNPPVYRINLSLPPSERYVELAKLYRDKMRALRGMFDELVHGISPKIPLKGVHWLARLSMRKLYTEEETDELRGISRVTDIDMYLLISLNTVLDLLMGCTSGGVRTKSASGTQMLHFRTLDWGMDPLRELIVQLEFVRDDNPDKVLATSITYVGYVGVLTGVRKDLSMSLNFRPVHDESRNLAFYTNHLLVLLGIRQSISSLMRECLFSFPDEPKPKKREESLSTLDKIVAHVPSMPTTAVYLIFSDGIKTVIMEKDHGTAVVRSSNSFIVTTNHDQEPGAASPKAIANEKRKNHIGLSLASSEAQVMVDLIEDSKERRDCIQARWDESVQKTIQAKKAAMKQVPEYIDNPDQPQGSRSSLRLRKKREAEAEEAERQRKSMQDSLDEEDVAVTAKEVMNWLTTHPVLNEETHYATILDPSKGKVTWVRQYDPSEWQEVNENANDSDVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM96</accession>
    <name>A0A1Q5TM96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM96"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39239" checksum="3569B7A65E8AFA95" modified="2017-04-12" version="1">MAFHRKLVATGAMGGLTDERRLSTELGASVLERFQVLNTNTACALLPSIPAAQRLITSLTVKGTGHFVSPYIQLFVPSTATRDKNNGREEDDADCRWATFYAMLYHSDLTHEAMSVWRETGDGITSRHAEFALEWFQFLESRCINDSFCARPDLIQDEALGKDLPSLPPAATTAKEVDAIKALLAKSAASDIPGQTPVFPRDVFLYPKGLCGIYAVARCLVPDGLAAESQVVIYGWPYAETVKCVERSGWGRVILYGKGTEADLDDLEKKLVAGERIQVLFCELPSNPQLTSPDLDRIRRLADNYGFVVACGETLGTFVNVDILLPCLPLTASLSVFSATASCSRAVRVSICGDFMNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ58</accession>
    <name>A0A1Q5TQ58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ58"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="18201" checksum="8AF2DE9CB2E8BFB4" modified="2017-04-12" version="1">MPPSCPHAVYTPEDCLAVTGSFYTAAHLGSSLRGLQLQEAYPEISNEDLEPEFYRLLSHTFTHYDHLYIRDTALPDRIYESTICYLEAEDLALATSLPTLHTHSKSESLRALKRVQRRRATIPDTILHARQELLNILQERVKWDLESTDEEDVDMEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ79</accession>
    <name>A0A1Q5TQ79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumitremorgin C synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP02347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="516" mass="58823" checksum="C06013E6374C80B5" modified="2017-04-12" version="1">MEQVEHDHGITTCPHSLGAGSDGNTHLLPATKPWIYFETLSKQYQSPIITFWTGRRPTLWICDAWTANELLDKRAAIYASRPRMVVFSELGAGQSNLVNMYYGDRWRLHRKLTHMGVGLQQVRNYRGFQNDESKVVAFDLLKEPKEYVSHFERYATSVVSIIGFGRRVAEYTDPIITEVIAVMQRAAELNVPGKSFPMLMESFPFLAKFPNWMAPWKKGLGKGQGRGRPFFYALAEEAAQNPDTDSCYAKKLFEEGPKHNLSRMEISSLSGNLFGAGSDTSSSTLVTFVLACCAFPDALPKAWEELDRVVGPHRSPTFEDEPDLPYVKAFVKEVLRWRSVAIIGGQPHAPIKDDYYKGWFIPQGTWVQGNVWAIHHHEREFPEPDRFNPDRYLKDSPDHRPFPGEKGYMTFGWGRRVCSGQGLAEQGTFITIARLLWGFRIEKALDRQGNEIPVDIFDFTNGLNMRPNPFDCRITPRSPEIRAAIGREGRQALQDLSRFDGETQYRMSTYYATEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ94</accession>
    <name>A0A1Q5TQ94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ94"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="90" mass="10223" checksum="F40F39BB64DE4F3F" modified="2017-04-12" version="1">MSSKNLEHFKGVTGIVQPAGVAVFANPYATSTKGNQQMVISGFLLKYYSGGSLQQVLKEDRVKKFRWERWAVQIGTALILFTMRRKLIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQM1</accession>
    <name>A0A1Q5TQM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein PAG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TQM1"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="319"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="934"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1417"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1715"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1933"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2358"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2443"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2389"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2490"/>
            <end position="2501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP02525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2536" mass="283783" checksum="D4C68E00C4956614" modified="2017-04-12" version="1">MHSREPSAVRGRPADPSTLAPTLQARRGHSGSKSPDVSAGHPAGYDVGLERRPSNSYGHHRQTSIVHGMQHSRNPSMAGSTASASPLSPELIASLGRGGFDEPGLPNKLDQLDSHHQSPGMAAGHGVPGTLSTIQDHDADDTINGSSASVVHKRMGSGGTIGGRNRSHSRSHSKHHSESKTVGEYALHHLFNSFVGKAESKINQAILKLGESDAPVEEVCGPGADPNFDQLISALGHIARQKPKPLIDTIMLWRKSKGDAAITARQMTNELPKPMVTENGVLMRRNTEPTQVPGDPASADRPQPPTPFLSRHDDVALVERRATVSVYLVCRVLIEIFNQSSLASITLDMADRLEDIVFGQIKTVDPDQISASPLRMANWRIYGQLLGIMSELNFTSVANRFLTELDKYQKDEVARGPSRDGDARAELLVLGMRNLRLPTSAEGWSKSCDFMRSVARLFVNAHGQKIKQAYCYVIEKLLLPVAANPIADLSLPRWKEFLDLVQPRLAQLLTKPRHWAAAFSLNVLLLCISNKETFASQWLSMISSLPARLKDRPTRAPALHAICRLVWTYFFRYSDSPTTTLRKVEEVAKIALPTGKRTYLSAEPAFVDPLIQLIRMIGFKHPDVCFRSIIFPLINSDLFLSGRELKIEQMEPEKMVIGIRSFLATMSDLETSDQLCPPFPTGSLPNPFMDSSTPAYFHRSQLLTEPKFGAAAQKPEPSSPCPVNISRLSDNVREYYLRFCEVLGKITILCDNTFGGQAVLDEKFGGTTPKTPITEAFGFGRRDDHLSTLDQKQGFYDLLHVAVQALPRCLSDHIPFNSLINLLCTGTAHVQSNIATSSADSLKAIARQSHAQHVTIGFARFIFNFDARYSTMSDEGMLGPGHIESTLRLYVELLRIWIGEIKQKTKEAASDQLEKSVSGSRALHLDLSSVLAHVEEIESHGLFFLCSQSRRVRAFAINVLRLITEFDSALGKENTRIIRILEADSQQILDLNDEQLTVAERSRIQKGKRRSASQNTLIELCSSEVSYDSTLWAKVFPNIIRVSFETCPFAVTLGREIVCARLVRMHKMITSLAERTRHPQYSPVDVYQNRPLGRSNMTAEILVEQWKLYLVMACTTVTSVGAQSQSQLANAQHARKASKGAQSSDKISSARSLFAFVIPLLSAERDSIRNAIVVALGAIHKNLYRTLLESLQYAVTTCNEEAKIRIGAHHRTPSSPQRNRNTDRLRTEVTHVYKLTSHFLREPEVYNDDWIVNNIITYAKDLRIFLSDAEVQNDWEFQRLRFHYCGLMEELFEGVNRTKDPSRWMPFESRKSAFSLMEDWCGYSPNQAQITEREEHMRKFAAAQPHEGGEMRNAAAAMEIEKKNLRAAALSAMASLCAGPISITTESGSVLQFDVGRMLSWIDIIFNTVSDKWHSIGRRALKNLIIHNKEHSYLMERSIEMCYVAERPKALESYFEVSTEVLIEHPDYPMQFWRILGAVLVTLGSQKREIRMKSAKLLRRLEERQQKSSRLQDFDISISDKTTAVYKLAQFETSKRLAILHSDLAFTLFSEFSLHFRNLRSDSQRNMVAAILPWVQAMELQVDPNGGPTASSYMLLANLFEITIRCSTTLPNQVQAMWQALATGPHGGNVQLVLDFIISLCLERKEQNFVEYAKQVVVFLAATPAGSKVIEFFLLLVIPKNMVQERKDLTPQPPDLKSLPYVADLATVLPVGNKQAGLSLGQVALIFLVDLMVAPVTLALEDVVKLLHVVLILWDHYTVTVQEQAREMLVHLIHELVAAKLADDAPAEHRQAVEDFVESIRQSDSAVVWEYEENQGKDEEADDRRVPTAMATVTREVVKFFSFEYEGVGDLWAKEALYWATSCPVRHLACRSFQVFRCISTSLDSRMLADMLARLSNTIADEEEDYQTFSMEILTTLKIIIGSLAPSDLLHYPQLFWTTCACLNTIHESEFIESLGMLEKILDRIDLSDPLAVTQLLEGQPPKWEGGFDGLQDLVFKGLKSSESFNRTLDVLHCLSGLPNNELIGDGTRQLFTILANLPFFLQSFDQGFTDQKPIMHASLLARVAENERCPRLAASLFGFANQQYKTEGVFLDHIITEIKSYYFPQLDFQCLIFLMGLLTNTTDWFRIKTMKILCVLIPEVDMRRNEVTCHGPDLISPLLRLLQTNLCPQALGVLDNIITVSGNPMERHHLRMSMASAVSSRAIRKEYERIQSLYGIPEETGWSVPMPATQSSMTRNNVHAVFYTCADADNMNVEDTMTPDVEFRADEFKDTFFPMRADTMKSIDTQTDGNMGDIVQKLDSLDDFFEETESSVQSFNPVAPPMLRGFTGSYIDTNAHLYDQQTAPILRKSLARTGSTSSFHNGLAESRPANFRFDGPGMHSPVNPPPHSSQTIRPASHTRSVTSPANNLYVHTQHPIPHSTPPVTLHESAFLSDDEIEDAYSDLDDRSHGKRGLHPPMPPMVRSATDGSHSLESMIRSGMRRLTGGAANNREKERSRDHLRAQHRAMVQTANSPRVPKVPEEYLAGPTSHPTSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TR76</accession>
    <name>A0A1Q5TR76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-strand DNA deaminase toxin A-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000623">
        <property type="protein sequence ID" value="OKP02722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TR76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TR76"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050657">
        <property type="entry name" value="Ankyrin_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057517">
        <property type="entry name" value="SsdA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147:SF53">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24120">
        <property type="entry name" value="SsdA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Single-strand DNA deaminase toxin A-like C-terminal" evidence="2">
        <location>
            <begin position="359"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP02722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="582" mass="66121" checksum="A6A49D60DF2E8126" modified="2017-04-12" version="1">MKTFPEADVIWWNASNYYVHCPFCDDVHRHGINWEAGKLRYSHCEMMESYSCCFPLNDQGEVAYEIDKKRGRYNNIFVSHESDREDDDDVDRLAIQLAQKATVAVHREETFASIHQNAKEIIITNPGHGIGPFKQKRISQPISDCALGDVKAVQNYLETSSEAHLFLEGRDSDGQTNLIKAAAQQSLPMVSLLIEHEAEVNAAANSGRTALMEAALFGWVENVKVLLENNADKSMRDSENRQAIDFAQDKHRNKREIYDRTGGNSMSSSNRRLGYIEDPFLRDIDRQEIVRLLGGENRKSKIVFGRPPTLIMSESYSFKHSPMQDSLVLYGPIEEYPISRRSQTVARLERGGKFPSVGAMSGWSHPSVQSLRVDGRQWTDDVFYISEVVGHLLPCHNYDQGRDGQCNACHAEKQLIAYFIDRHVFLPRDGQPDSELETEIELNDDKLEEFLSTTQTGRQVTSLRKRKKDLENELFDGDEKLVGKHDQIRALKLELKSVETTLNRLIATPQARPLLWLESQLEVLNHQKDRHEDLTRMANAPPPASLTEAVILISSPPCQDCIMFKDKVNSFFGLSLQLFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRP2</accession>
    <name>A0A1Q5TRP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRP2"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="339" mass="35820" checksum="A1EA412CB68253DB" modified="2017-04-12" version="1">MTFTNRAAWLQAEKANPLVVGAGPTPNPSEDEVVIKVSYAAVNPADWMSQDFALPPHIKYPTILGLDVAGTVAQLGSNVTRFKIGQRVLGHLDGLATARPSNNGFQLYSTTREIFVSAIPDSLPLENAAVLPVSISTAATALFVHLKLPLPSLNPTSTGQRVLIWGGSSSVGCSLIQLAIAAGLEVVTTASTANHDLMRSLGASHVFDYRDSDVSEKLFGVLRDGDLVVDAISTKETQTTCGEILGRLGGGTLPVMQPQAGTFPENVKVVFVICIDVGFTALDVGNAVWRKYIPEALAAGKFQAKPDAIVIEGGLEKVQEGIDILRKGVSAKKIVINLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXK9</accession>
    <name>A0A1Q5TXK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXK9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP04961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11068" checksum="4A3DA210CCA7BCCC" modified="2017-04-12" version="1">MAATRTAEPYLGYWIDFGLEFAHHREKAIKKVDVSLQALRVLAGSDWVSLLLSFAQNLLVNGNSQMLYAVSAWYQPMAISKLQAHTTSQPFVAIQKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXZ8</accession>
    <name>A0A1Q5TXZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000606">
        <property type="protein sequence ID" value="OKP05105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7350" checksum="3689A1082CD1CFE7" modified="2017-04-12" version="1" fragment="single">NWTRFKADVSLNTLSCIMSATLAGLFWADKAPVGREVLLQMSAIPPTLQMTTWGWHFGIGGWLAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U068</accession>
    <name>A0A1Q5U068_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Quinidine resistance protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U068"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U068"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP05851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="554" mass="59897" checksum="F0508D2BC4C48581" modified="2017-04-12" version="1">MDATKQAIQGVVEIHRSSPENHPACETVSNYEQAPYSLPIKPNENDPSEQKEGDVVGEAPYSVLPHSEKAFVIVVGSFAALISPLSSSVYLPALNSLARDMDVSVSLINLTITTYLIFQGLAPSFVGSLSDGHGRRPAYIAAFIVYLGANIGLALQNSYPALMALRCLQSAGSSGTIALGSAVVADLTTRAERGKYIGYASMGISLGPALGPIIGGLLDHFLGWRSIFWFLVILSGVCFIVILLVLPETCRAVVGNGSVIPPPGNRPLWVILAPKLRSRRDERSPDPTTIQKPKRRPNPISSLLILAQKEAGLILLYGGLLFSGYVAVLSTLSTQLSSRFGFNSIQIGLCYLPIGLGSISSRWTVGTLLDWNFRREAHLQGMAIHKNRQQDIENFNIERARLAIALPMIYVGSLSVLAYAWVMQYHTSLAGPIVMLYFMGLTTSGSFNTLNTLVVDVNHQSAATAVAASNLCRCFMGAGTTAFVGPLIDAIGIGWTGTIVAALWGLFSPMLWLIFLRGHSWRQEQAAREQQRENASEDPQARPDLEKGSREVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0R1</accession>
    <name>A0A1Q5U0R1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000600">
        <property type="protein sequence ID" value="OKP06067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0R1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="22144" checksum="8D72DF936AD8EDBA" modified="2017-04-12" version="1">MRPEARDTRHTIGLLCEQPHLDALAPCLNQLSATVVLGPPDMPWLRPAPRGNCSSMPTAPFTAITSTISTTTSPFSCLVFALLPSFGHIRTYAWHWVATVPSDRPAGVCDEQSMTRHGDAIPPGGSPRTAPSDAHTESAYSVFITSFATFPFQYTSILQLEGWVYRIAMTSTFRERARGPEEYRGGLDKLVGIWAACRISCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0T0</accession>
    <name>A0A1Q5U0T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0T0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0T0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="176"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="551" mass="61964" checksum="BB38D7640A757EFB" modified="2017-04-12" version="1">MDMSEVDSRSDSTVVQEQAAPTSSSANLRVCDKCISRYIEISGIAGLSGGAGKAASTSVPPGCLDVPAELLTSSRVEDFFNLIHHSIPLFRKDRFVEQYRNGTINPCVLVTVLVVTAKLLGPAEIAQAPDIESCLQVLLRDDPFEGVSQPNIILDAFRQSCLLAYYRFHQFHGEDAWDYVGQLARKALRLGLHQLDSFDGYNLFGDGGDDLAGVADLEEWRYVWWCIYCLDSYSNITAATPFVLEMDGIRTALVSTSLEDQGQDPAEPRVMDFLPTNTKDLWHMSAVMGIMRTPASYFNMHIVTTTILRQAATIRRLRRQNLCEILQERHRQFEDHLSAVLLSLPPAFLSETRNVLANEPSLSHHARLVCLLHLYSARLLNVITVHTLDDAAWASSWQRSLVYSEDIVAVVRHWDSRYCSTVDPAICLIVFSVLVLLYMHEIHEATAALFTLRHRLEAERNLLILFLQQFSQTWALPRLLRESFDNFTNMVKGPLTSHDIGLLFTQVPGPFQPWRGLFGLAPSPPDPLRIPHSPMIEIAGLRFSSDFFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1R4</accession>
    <name>A0A1Q5U1R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoskeletal protein syp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1R4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1R4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09264">
        <property type="entry name" value="AP_Syp1_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049609">
        <property type="entry name" value="Syp1-like_MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD" evidence="4">
        <location>
            <begin position="601"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="519"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="854"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP06428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="894" mass="96723" checksum="93171A72716D53F6" modified="2017-04-12" version="1">MELSRQEYPALLATLHPNQASTILNDRIRLINKINADIADFLQERRRVEEAYAQSLRKLASRPQLDNGAALGIFQIPWQRIINATEALAVSHETLATKIEEDVERPLREYSNKNRDMQSMPGIQSNLAGLAKNIDTAQKKVDKAKAKGAKGASNLSSAIASAEEMNQQWESRAPFVYEQLQAADEGRLNHLRDVLTQLETHEVDQVERCRQAAESCLNVLLNVETADEIKTFVAKMAGNRTPLSPVTSRRQNSQAETPPAVPAAATPPLAAAPLAPPPHIQDDAASQRSERSETPAPAAVQTPPAPEPVPRHTPLGGLRRLGTVMNRRKSVIGPTAGSFDRKAEKKHRSPFAPFKRSDSSREMQIPESPPSTADRPGTSFTEESSLRNPSVSQDHNVPDTIAPAPIDHQEPSIANGTSAEAQAGLVSNGTAQAHVDSDGFTERPSTVDEITRAQREAAGYVTNPDEAKASSNMKKHSLDDSGVNLTIRDQPIFEDESQAKKAMDDMANTLRMRAPQPGIRRNAGTIRGRRDVRNTVFVPNSSTDMTATSAASDLYGPSSPIRHAPSPSTATEDHAMSDTTSVRSGYTMHGAGASIHPELHEPGLNASIIETVSAWFSEGNVAKSSVVGELALAHNPTPGAPIENVRIHLDNFPVLEKVAANPHFVHEASKDGTDEKRGEYDIHLGSISRPIPTVAFKYQVHLDPTNPSAYCPVIFKPAWNLQENQASAIIFYSLNPSFTSATTGSITLKNVVLTVGLDIAAEDEITKEPRESVAQATSAVMYPNSGATFRRKTSTVVWKIPELEVKAPGSGGEDGKFLVRFATATPGPRKGNVEARFELRTTETGSRLGISRAPVHAGPKEIDPFADDGKPATPVPWEEVPTARKLVAGKYVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4R7</accession>
    <name>A0A1Q5U4R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4R7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4R7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="194"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP07465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="432" mass="47589" checksum="9ABE0EA0E74A5950" modified="2017-04-12" version="1">MASQKFAAALASIEALSHQPTKLEQYNNLLNDIVSRSSGDELAQDIVYYLDSILNEEISIASARPLLDSFIAALQKFDPEVKIKTGQHAVTLLQSRATSVEEQDSQIREILAEAYESQEEYSAAARALSGINIDSSQRLVSDAAKARLWIRIVRYYLEDDDTTNAEGFLNRIKNLPSKLEDHDSKLYFQLSQARILDARRRFLDAAQEYFNVSLAPGVDEGDRLAALSAAIRCAVLAPAGPQRSRSLSRLYKDDRASSVEEFSILEKMFLDRLLNADEVAAFSKKLAPHQLAVTADGTTVLDKAVIEHNLVAASKLYENINVDALGEILGLKSSSDFSAGEKAEAYAARMVEQGRLRGRIDQIDGIISFDSELAAGSGANGASLRQWDQGVQELAEDVERVATSIADQFPVSDNLLSVKHYFHADIYPGFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5X1</accession>
    <name>A0A1Q5U5X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5X1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF2">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="13648" checksum="800957B0B5387B60" modified="2017-04-12" version="1">MAAVTYANMRPGVLLHKLILLELILALAHGTFIFAPDPVYGWYLAASAIGLIISWSLHNVIAWMKNRPFMGRKISLLYVGTIILAQPYWATEIYANFAYFNNVNQTVYEKIRPWEALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5X6</accession>
    <name>A0A1Q5U5X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000576">
        <property type="protein sequence ID" value="OKP07882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5X6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5X6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="244" mass="27820" checksum="4F526F7B5AF5A9AB" modified="2017-04-12" version="1">MESPPRNTTQISDGVEPTAEAGLCVDEASEAKDTLHRVQFEFVSLIPDRVARSHAMKMYWRQKKGGRERQEKKWNENQRPILPLLVKKTSELQQRVPEELGLQEVTLGLAMHADEIHSHLKTDTISPFRDIWMPLDLSNPASFNGIMAHAAAHLSQIQYKEGNQDSLEFKTDAIESVNKWLSDPATALNDEVFAAVLRLFTFERHWGTSERSDLHKNGLRQMVEARGGYKTFETNWKLQLALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9T8</accession>
    <name>A0A1Q5U9T8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9T8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9T8"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="120"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="585" mass="64163" checksum="CBF3B6858D18B36B" modified="2017-04-12" version="1">MDYSAISNDPENHTGASPWGSPRADRTSFPTSGNGDIPSSPLPGQDHSSAAADRDDDAIAQAADLSAQLQSAQLGDPDYGEHPSPFAAHQSPAADQQQQQVPARHQTGMRQASRPPAPAYKIQAKITALERTGKKDPILRFDVHTNIPKFRTTQYRDVRRTHSEFVKLADHLISANPEALVPAVPPPVTPAGAGTDEDEIRVKASMQRWLNTVLSNEVLIQDDEVMLFVESDFGYSPVLRMKQPATGVRRKMLKQFAPPPDDTPELQAARPAVKMFYLGAMDTSHKVDRVVKSRRGVGLAESDFGVKLGQMAVQETHPGLGMAYRKLGKIIQTVGDYHAIQATAEATTLGEPLSYHSSDAFIVKETLTNRHILLRELIQAQQSARSKQAAAERLKVSSSVRPDKVDEAINSLEEAKNHEDYLTKRTQRVTTNLLQEKRKWFDRTTNDLLFSLREYTLRQIEAERRTLATLESVRPDIRSIDASGGLSRLGREAHPAVRRSNMASSQGPKGDAWSGIPRRSDNLGRSMSGSFTAPGLNEDEGEEDSQAESGQGRARATSQVGSIAEEDDDRLDARNAASRLAASTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA05</accession>
    <name>A0A1Q5UA05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing protein YAR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA05"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="24127" checksum="DAD5343E557B3C0D" modified="2017-04-12" version="1">MSASTPKPKPTVPVALSFEAIDDLIYDARAGDLEALNADIATLASQHNCPESYIVASAIDMEDESEGGTGSCVLHFPAANGNSEILNTLLQKLSTLDVAQRTAFVNHRNHSGNTPLHWAALNTHLECVKGLVEAGADVAIKNDAGHDAVFLAERAAWSAAAEEEGEIDENAEEPQEIEMTIGEEQGEGEGEKQADAGEMSAGRQVVEWLLSSEKAAGLESSATEGEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBM8</accession>
    <name>A0A1Q5UBM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000437">
        <property type="protein sequence ID" value="OKP09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="12198" checksum="82F0F4961F124E20" modified="2017-04-12" version="1">MATVSQRKLHVFRVTGLLRELPDEDLKTAVQEALNDNFTHDESKSSDTQRVALVQFGGGVPQFLHELRVNPLGDSQIEMGDEDINFDCHFFGFTQLYTTDDKEPVVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBX0</accession>
    <name>A0A1Q5UBX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA oxidative demethylase ALKBH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4662</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBX0"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CUE" evidence="6">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="267"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="8">
        <location>
            <begin position="416"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="488" mass="54554" checksum="184511DF82470F0D" modified="2017-04-12" version="1">MDDFVSRKRRRLSQSSVEASATPAKAPSTPNPDSSGEDSTDIKIAILLSLFPDLKQENLLDILVSCDGSVEAASSLLSTQVTSGSPYKKRATSASAVGAQTSLSSHVLTKAKDGSVTTLSDSLVRRKPLSTKKGQTLHLYSPEDIAAYTPCTIIHNFLPTEQANALLVELLDESKHFSQYEFQLFNRTVQSPHTTSLYVSTPEEYKQHTSEYKYGGTYRSNVRQATPGLRSVSRKVQLAVNEAVQARIREVYSDGKKLKYQSSKEWRPNAAFVNCYDGPAENVGYHSDDFTYLGPHPVIGSLSLGVEREFRVRRVLPRDEEDDTGQTGTEDKRGTPSKATNDRKSSTARADAQGQISIHLPHNSLLVMHAEMQEEWKHSIAPAQTISPHPISGNRRINVTYRWFRDTFHPRNTPRCLCGEHAVLRCAQRKQETRGRYMWMCYAGYVPGKESCSFFQWAEFDDDGDPVWTHEPREEKVAPALTNFSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCY5</accession>
    <name>A0A1Q5UCY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCY5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11240" checksum="C95AF9A0F6F96096" modified="2017-04-12" version="1">MGDCTNLLLYLLQSEPEIDSRDMWGRTPLSWAAEYGSLHAVKILLERGAYVNAMDYEGGTPLTWLIYAGNPNSKNLAATGAYLKERGAKEDTMRGITRAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDE9</accession>
    <name>A0A1Q5UDE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000316">
        <property type="protein sequence ID" value="OKP10481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDE9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="34838" checksum="7D5060B122246D08" modified="2017-04-12" version="1">MEDTAGLLTAELNDLFERIGLVLNKIETKLPPEECTKCVQGLPAPSLLVFSRLLLMMGKRLQNEPIHIPTDKSNAALNCHHESPAVVNNAREDLCPPGDRGEDPSPVNHNDTLSNEASHFDHGGTVDHRQSHRNSSNPDQRIDLYRPFSISTSLHNALIKHQGNPQSFFKSTHRIGVQVAGGLTGAFFRLHQKCDDIQDEKIRDIYLQMHLLYRRLEFRNLFLLAKELGYHTGDRWRRDACLQLAAQIKQKHPSLDADELLEEYVRLGRAYNKWAEELGGPGYLLILPLTVTEYQCVAFSSSQREIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDP3</accession>
    <name>A0A1Q5UDP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ceramide-binding protein SVF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ceramide-binding protein svf1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Survival factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_3883</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SVF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDP3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.370.10:FF:000001">
        <property type="entry name" value="Survival factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Svf1-like N-terminal" evidence="17">
        <location>
            <begin position="51"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Svf1-like C-terminal" evidence="18">
        <location>
            <begin position="212"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="41265" checksum="EA91EDB0041F4685" modified="2017-04-12" version="1">MEGSLSAAVGTQEPIYGPEAIQSVAQQASETPFTVLEKDQLRWKAYQYTNVETQTFYIMADDGHLFMVQVIYSNIAGIHTTAHFNTKIFNVKGDKPHVWHTDALSNCMFDEQMHSFGADNLTLTLNEEGDAYQIKSTVNADSIVDIKITRKAPGFVAGKNGTSYFGTDPKNPWGSMYHGFWPRCAVEGTLTTKEKTYDLTGRGVFIGALQGMKPHHAAARWNFINFQTPTFSAIMMEFTTPPSYGSTKVNVGGVLKDGEIVYAGATNTITHTASAQDPESDWPEPTSIKWEWAGKTADGQDFTAVVDGPLGKRQDRVDVMGEVPGFIKTIAGSVAGTRPYIFQFSPQEKLKIKVKVGDTETEEEGTMFSESTFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDZ5</accession>
    <name>A0A1Q5UDZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDZ5"/>
    <dbReference type="OrthoDB" id="10264507at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="16596" checksum="1F8A32F53F11A7EB" modified="2017-04-12" version="1">MSSIFCCSSPSPYRPAHLTHEAKFSPFIAWAKGTGSSPSAVSASFFQGPDKMPPYAIQFVRQINFGAIEAKKYFVPYSEAPGGRVDFVEVTEQDLIAWNFQKLNSYKNFKCTAHNKFFEINLYQKDPVNQHHWRLNIARPASEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEM8</accession>
    <name>A0A1Q5UEM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEM8"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="8">
        <location>
            <begin position="152"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58219" checksum="44BAF3E96DDB39C3" modified="2017-04-12" version="1">MHRRVGKPKSRKGCVTCKIRHVKCDEQKPECNQCTRSDRKCDGYSDSSQRQLQEQIKKDIPVQRWHINPDQSFVLVPGSREERQYVHVFCTQATHALSGFFPTEFWTRFLPQLSHRYPAIRHAVSAVGAVYGKQLLPANADSADVEQFTLLQYNKAIQSFLGQLNSPQTVGIDLVLVTCLLFVCLETLRSKNVRALDHIQSGVQILAARLKEKKVTVNNEFERELLHIFGRLNIQTGLFGRGILPLDIHPEKSTIAGSGEILAFDNISQARETLTNLQCRALVFIRSVGSKSGITYETVFEQQIKEQKSLEAEYHTWREAFDRLGKKSSKTTGISDPRAPLALLIEHQTSLVWLLNCISQEESHFDNFTSNFEEIVGLAESILELSPKTESQPVAEQFSLDPGVLAQIYWTANKCRDPLIRRRAIAALARCPARQGMWLRPLIVQVASKIVEMEEEAICSLPVKERRVAEKDRVYEALIYPEEDQRSPCPVGFLFKPNGVNGEFECRQVDVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEU1</accession>
    <name>A0A1Q5UEU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEU1"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="334" mass="35690" checksum="2A326696C1A3F38B" modified="2017-04-12" version="1">MSPRVLIFGGGSIGAVLAYLLSKSIAASDIVVVCRSNYDVVATHGFTINSTVFGMNENVKPIAVRSVTEAVQAYPDGFDYVCVATKAVVNGTISQPELIKPVVSAKTTIVLMQNGINIEEPYRALFPDTAIASVVIYMPCTQTAPGVVSHTVYAKFLLGTYPAKSTSEHKTSTARFVEFLKQGGASAVHEEDIQLARWTKLIVNGSQNPICALSRLRDVQFLGAAPGAASFTRNLMSEIASIARAEGYSEVDDSVVERQLELSTSRVPPGVEPSMMADALSGQRLEVESIVGNTLRIAQSHGVDVPRLETIYYLAKGLDMSFAIPEALLGGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFF0</accession>
    <name>A0A1Q5UFF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFF0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="728" mass="80584" checksum="937F973A32842432" modified="2017-04-12" version="1">MEKHEEVGYVERKASKAQRILGTDLPLPNPQTKWEKQKSRRQSLRTPDSSSAQQNQQNQHSGFAAFPSSRNSIAPPPNLRVRASSPLLGHNYQSQEAAPPMPKHSKKVHQSGSSSTLFSYFSSKESIRSSKSSPTTPKQQQSLQPHIRHELGLDPQVTYKQSRSATKEQEKEKDSKRKLRPPRIDLSILFPKPRNTAPPLLSPQRMTNSPSPVSTVVSDYPSNRMDRGGIPPSAKKFGEPLPQRTSVIPNEGPKKNGDRSDLLSIPESKDGEWYDHPLERTVGTSEIDLALDRYAGRRSLFSRSSVYTASREQLKPEPNRPAETGIAARRGQAPAGIQHKDSYLIPTTQPTEATRHRALTTESSNSRGGKSAVSKKSSKSTLRNKDLQNSSVLCLSSSEDEEEEETPTTQQGKANKDSRRSSVATYVEYEPEIYTARAAQAATAKKVHRAPSTSSRGSHPNTRSQSNRRHTSIASTGKSSTTTRRTANSKRSSHIPIIAEPDILNQFPQQPLHTPQELKEMNRRSRVIAVTRQEQDLLEAMRQRKGKITPSIFQYSNGTSETDRNSMASGPSRDSFCGSDTSFLRLSAAFPPFHARTDQGATHMDKDGSPSQSSGSDTEQKTGNPIASPQFSTGYTESLPSPATSAASPLTPTLPIHRFSPLPSPKPPPRGPPPAIPEDQKRHSRRRTDSSEAIMLNDNGEPQRKHDLPLWSFNFDWDHDRANVAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFJ0</accession>
    <name>A0A1Q5UFJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFJ0"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8638" checksum="904DE2EF3B9AA1DC" modified="2017-04-12" version="1">MGLIDKLQAKLELYRLEQRYARRKHRSTFSTGAQYVDGEYVFNTGTNSPTSTVSKHSTGSWRPSALRGSQESRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGA7</accession>
    <name>A0A1Q5UGA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGA7"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="11759" checksum="3E5ED25DB355A8FF" modified="2017-04-12" version="1">MSEINVAASLYPKPEKFDEVAALVAEVVKKVQENEPGTLIYYAIKVQDKNEIVIIERYKDQAAVKAHSKSAYFREFFTKLAPLMAKPAEIRAGAFLNGQRGVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGC8</accession>
    <name>A0A1Q5UGC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_3007</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="24383" checksum="B413F75CB8444459" modified="2017-04-12" version="1">MPLLDSHLEQIALSSRAISELPFPPPRIFTNALLGSHDITALIRDTEVHERALFQVDPSTKAQGAQRRATRRGTTFPAEPETESMASRIYSARNNRNQSAVARVLGSDMMDEIKRPVAGAQEKIASLRYRHEMIAESIAQLEDRVAASTAELEQMRRSYGDNEDDYAPAPVSQPNTPDVTDEDIERELAEIRELERRKRTLEARVTGMDRDLGRLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGD6</accession>
    <name>A0A1Q5UGD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Negative regulator of mitosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UGD6"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000217">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2098" mass="231063" checksum="132D915A1AC68732" modified="2017-04-12" version="1">MATTRSLGLHEPSAVSYLVTEGILPPDPSEDQYKWTTCVDENGSTGPVDDELVWTKHCVVWSRAGVVKRIFRLDPEKEDIRHALFTQFAAGYVKRSVHESATTTASNRYRTTGTTTTARAGGQNKRNGGKSTLASSGSTLDLHGDARVAVVAPQQPNEKLSRALVVVLKSQAHIFFLAGNSHTIPLPFEVESVFATPRGLLFQRKIPDEPPRPLNLTAPPNSFMTGASLFDPGASQSSGVPRPLPSKGKRQSLKLPSLQSSTWGPNPSATSDLPRVFSLIDPHSEMGLVVTSAASRGFQSSISSATRRRPSGLDVLDPADEIVYISPKDELSSQGQQETTGPLILVLTMNTNTGLYTVWTARYREDEIDGSAQDKARRHTEGTRSKRRSSHFGMTTGATTPAARPPAGRESFGPWTENWASSQQPENKNDAEDDLVSRVAQDFGDVGVPLKTSRRVSSLLARTDLATSQDRITFSDLATGSQSNAAPHHGGLRQSIGAASARGSFGFNPRASLPPAAGSIYSTAGSFVDAPVDRLLEELNSGGLSEGFENIALRESASGLPEELLLSKVESFSAMFSGSFRGSIQHVSSRHLRVCTLSSSDYTSTQNGNVRSVAICIVDQDSQNMSIVNLRAERVATSKSRKMAKKTRTEKRRPLLVHATGIQHIPNVWDACSVTDGETSRILTLTVLENGQRELSLQTLWGSPTKIDIPCPLQLFEPHGVSASKLVNRSRESGVNRVMADPDLVFNAFDHSCSRGKVDLIDTEKQRHRLQIRMEPRNELVKKILNVCKFVLRDTEKAGDGMLVAWWEVIKWLQGREEVENDLEWTAMVIVLFSLAVPFIKQSQPQTPARRTRRKKGLLRSSSGSYIDLESWEAMLDLESGSSGVVAPWMNSSAWGWIVEQDAIADMAAREATRTPKNEQPNASRSTYRHNSYLLRCMSLSREFLQSPLGARATGRDGYLPISGAFAENTRCTALGTILVGLHLLREEQKLSTSDTEESQQPLGLLAPILAQLGGWLGWQSWNWSEDSYYGTEMASMERWQFEDTRITQLNFPAEPFPPPSIFSFLIEATRQGPSPFLTLLDVVNASDRTPRKGRLWKECFNVTPRSLALTGFLSDVHRVSTPLEKIQLLHRWGLTKSIIDTFPEGVSAPLYEAVMHCQNEASTSWNATLLELIDREDLYMSMNPVQAKSFAVPQQPVVSHDALRDFHNISSSSLEIDANHAFEASAEADRFSVTRLVFREDRRYVEAGRLLNQSRAPVADCVPEPEWTDSELLEAQKEIVQLVSFRTLSTPAGRGMLYFSGRLPLLTEKLPIPSFSLQCVMKPSNVTVSAERSAFTEEKVCWAFFHNGVSTGLAISKASKGIDTSWILFNKPGELTNRHAGFLLALGLNGHLKNLAKWVAFKYLTPKHTMTSIGLLLGLSASYLGTMDTLITRLLSVHVSRMLPMGAAELNLSSLTQTAGIMGIGLLYCGSQHRRMSEVMLSEIENTEQDEQSGSQEDLRDEGYRLAAGFALGIINLAKGKDLRGMRDMHIVERLLSIAVGTKHVDLAHVLDRATAGATIALAIIFMKTNDQVLAQKIDIPDTTVRFDYVRPDLFLLRTLARHLIMWDSIKPDSKWINASLPKVYQRRARLGGVSQLRSEDMPFFNIIAGLCFALGLRYAGSGNHQARDLLLFYLDQFIRISRLPVLNYDARLARNSVRNCQDIVSLSAAAVMAGTGDLALFRRLRALHGRVDPDTPYGSHMAAHMAIGMLFLGGGSYTLGTSDLGVAALLCAFYPIFPTSVLDNKCHLQAFRHLWVLAAEPRCLVPRDLDTRRPISIPITITSDGGATRTLTAPCLLPDPSEITRIEVRGPDHWPLVLDFSQDDALRDKFRQGDPSVYLRRKATYSPSSTSTSIFASTLTGLSEAQDILPASSAAAAANPAKGLPPSTYPNHTTLLSGSLATAATPSQSPWDWIFALPSLQGLDIRERSLVLPSSFPTPSTRINKQLITAPPWLRTSAVDTRLALTQTVRNIVQAARGRGADPDEVRDRVWQLRLLFDWLDRVQAGDEREISAGEEQVQAQNQTSGLWLRRDFIEEARWQIWGVQSEDHGDGVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHD1</accession>
    <name>A0A1Q5UHD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHD1"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="31632" checksum="B3BA7B948F27F666" modified="2017-04-12" version="1">MSGVTEKARIASFGGKLLKLGHSATTTRCEMSFNLYLPPGAVDSSATGKVPVLIYLSGLTCTAENCSEKGFFQHGASKKGIAVLYPDTSPRGLNIEGENDAYDFGSGAGFYVDATKAPYNEGYNMYSYVTEELPEVVFKAFPQLDASRVSITGHSMGGHGALSLFLRNPGKYKSVSAFAPITNPINCPWGQKAFKGYFGEDQQEKWKEHDSTELLKKWNGPELDILIDVGTGDNFYKQGQLLPENFQAAADAAGHKGVNIRYQPDYDHSYYTMATFADDHIEHAAKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHD2</accession>
    <name>A0A1Q5UHD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000271">
        <property type="protein sequence ID" value="OKP11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHD2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="220" mass="24985" checksum="2BAD57E19BCE1D21" modified="2017-04-12" version="1">MGQYWLVVCPSKREYTTQPFGGKLSELLFSSWANILCELIEDEWAGTPLICIGDYLRPDDLPATIQQDNLHLIYSEGDTISKPLRYDIVEEKFKLCFYEEEEEGAATISAVEASVNPKNRILRNLTAKQYVWEDKLPSGITIGDIVVMRICWSSESSTGIEGGKYLAKGDWAGHEFDIVDADMLENTNGEWEDVPGDTRDEVQDLWSSHFGENWETEWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJT1</accession>
    <name>A0A1Q5UJT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Granaticin polyketide synthase putative ketoacyl reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="20365" checksum="C63E0053E6FCD0AF" modified="2017-04-12" version="1">MPYNLRGRNILIVGGARGLGAVVAEKFAAEGCDLAINYLFSQEQADNLATDLAKKHGINAVTIQADAGVKEDCIRLVQATIEKLKGLDIIISNAGWTKFTSFGDLDALTDEEWDKGITAGGSSMAYSVTKSAGLHLLQCLKASQGPKVRINAVLPGLLLTEWGVRYSPEQIEAWKNKSALKHEVSPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKI0</accession>
    <name>A0A1Q5UKI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000165">
        <property type="protein sequence ID" value="OKP12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="8057" checksum="62999DA8EBF7931E" modified="2017-04-12" version="1">MHVVKEESEKDSSLEDTMYPLELHLVRGILCYPIPNSLEDEWSPRDTGAAAVVQYCDVLGVGPLRGLVQVEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKI4</accession>
    <name>A0A1Q5UKI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000162">
        <property type="protein sequence ID" value="OKP12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="22614" checksum="308B9BADA6EF223C" modified="2017-04-12" version="1" fragment="single">PSSFINRRPKLRTRFSRRYDYQRALNEDPKSIRQWFATVQSVIDENGIQPEDIYNFDETGFAMGLISSQKVVTRAEYYGRRSLLQPGNREWVTTIEVICADGYSLPPCIVFKGKVAIAGWFNENLPKDWRIEVSKNGWTTDEIGLRWLEKHFIPHTNSRVRATLRPNSTESVPKTILYHFVYLRIHRIYYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKR5</accession>
    <name>A0A1Q5UKR5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKR5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKR5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="442" mass="48033" checksum="9360C1E490E7D899" modified="2017-04-12" version="1">MADQGDRVFCHACGGVWLLDTGEDGHDNSQTCPHCESDFTEIIEIPPDSPQPEPAAEPHLPSVNPWADHNPWAQQESTRPQTSGWMESGSPGYSHRSYRSPDGRFTFSSTTIGGGYSSRQDAQPNPMLPFMVQSLDTLFQGLAGTHDGHQTQRGPGMNVHPYPHAAGMREPDVMHDPFQAEDEHARRHEGLYPHDTNGPQDMTAPLQTLADLLEAFQGISGAQRGTARNPAENPFAMLSALMRNNDAVYSQEELDRVISQLIDHTQQGTAPPPASDTAIQSLPKKKMTPQMMGSDGKAECSICMDPVELDTEVTVLPCTHWFHFDCIKAWLSQHNTCPHCRRSIDLPGVTSTNTGAGTSENPVVIPDSPPASPQRQRRRSSPFTSRSIRSARSSISRSSHNSTSPEMGGESGTRRGSRSESSRGGITGWVWSRFGGGGGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKW2</accession>
    <name>A0A1Q5UKW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKW2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="207" mass="23286" checksum="B35B820FEF2E055F" modified="2017-04-12" version="1">MLDRLLPNLLSVGLQLRAAFLLRRFHRRANSQIDQWSTVDKSAFATLTIGGHDLGFSDIVWHCVITPNTARWGSTNRANCEDAESKARGLLQGELRGRLTETYLRILKKATKEGFKLYVAGYPQFFNDQTSDCDMSSFHYWWGGYNATTDWPSYRTVFLTTDLGAELNALVTGLNDVIQAAIGDANQQYESHAVYYANVDTGFTGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL68</accession>
    <name>A0A1Q5UL68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_1312</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL68"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17946">
        <property type="entry name" value="DEADc_DDX24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="211"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="470"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="754" mass="82865" checksum="5FDC552ACBA47DDB" modified="2017-04-12" version="1">MGQKRGRDPKAQAPESKKRKKAAKSGPVADDDSWDGVVGIDDLNWTEVALPDRLEDATGFLGLEEIDGVDIIRSSGGGEVQFKAKEGKPRKSILKKPSAENNGEEWDGFSDGESNEKPTAVPAAETQPAKDEKKTKNKKEKKVKEVKPKEAQPKRDPNLKVGLSFAALEEAGEDDGADVSAWDKLGLSPEILTSLSKLNFSTPTTVQKSCIPAILDGHDVVGKASTGSGKTLAFGIPILEHYLEKRGKKEDEGKKPKSDPMTLILSPTRELAHQLAKHIGDFITNAPDADARIALLTGGLSIQKQQRQLANADIVIGTPGRVWEILSTGSGLIRKMQGIKFLVVDEADRLLSEGHFKEVEEILGALDRKEQGDFPDMDEQEEVAEEEPSVRQTLVFSATFHRDLQQKLAGKSRWTGGDLMDKKESMEYLLKKLNFREEKPKFIDVNPVQQMAEGLKEGIVECPAMEKDLYLYSLLLYYPKHRTLVFTNSISAVRRLTQLLQNLQLPALALHSSMAQKARLRSVERFSSPTSNPSSILVATDVAARGLDIKGIDCVIHYHAPRTADTYVHRSGRTARAGAVGKSVIICAPEEVVSVARLAAKVHTQSGKKGPIKKLPLESLDIDRRVVSRVRSRIELARKITDSTIAKEKISAEDNWLRSAAEDLGVEYDSDEFDESQGKGRGRGGGRHQKEKQASSITKSELAGLRAELKHQLSQRVNIGVSERYLTAGRIDIEALLRGEGNNSFLGHLDPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULL1</accession>
    <name>A0A1Q5ULL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULL1"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="143"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="529"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="820" mass="90302" checksum="B22E12CA1DF45A79" modified="2017-04-12" version="1">MSAEPDHTHEKKRVNLQDASGAEKKEELDTSTAILKKKKKPNSLIVTDSVNDDNSVIALSNNTMETLQLFRGDTVLVKGKKRKDTVLIVLADDDLDDGSARINRVVRHNLRVKHGDIITVHPCPDIKYAKRIAVLPIADTIEGLTGSLFDVYLAPYFREAYRPLRIGDTFTVRGGMRQVEFKVVEVDPPEYGIVAQDTVIHCEGEPIQREDEEGNLNEVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKRDKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEIMQIHTKNMKLGEDVDLETIAAETHGYVGSDLASLCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRYALGVSNPSALREVAVVEVPNVRWDDIGGLEEVKRELIESVQYPVDHPEKFQKFGLSPSRGVLFYGPPGTGKTLLAKAVANECAANFISIKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKSRGGSQGDAGGASDRVVNQLLTEMDGMTSKKNVFVIGATNRPEQLDAALVRPGRLDTLVYVPLPDQESRESILKAQLRKTPVASDVDMAFIASKTHGFSGADLGFVTQRAVKLAIKEAISLDIERTRAREAAGEDVTMGEGDVEEEDLVPELTRAHFEEAMKTARRSVSDVEIRRYEAFAQSLKNSGGSSFFRFPSAGEIQNNDTFGDAGNDDSLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULU5</accession>
    <name>A0A1Q5ULU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_659</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULU5"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1055"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1184"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="179"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1025"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="318"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="701"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="780"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="809"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="890"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="891"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="972"/>
        </location>
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            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="978"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="998"/>
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            <name>Mg(2+)</name>
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        </ligand>
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        <location>
            <position position="1001"/>
        </location>
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            <name>ATP</name>
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        </ligand>
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            <name>ATP</name>
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            <position position="1002"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKP13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139581" checksum="3AE96910FE755A80" modified="2017-04-12" version="1">MSSSHDYLHPLQRPDDLGDYSGSDDDDLDLEELDPDAAPPQAPRASREYASRSRTYGPGIALRNLRVGVGSRWKRSASGDHGEVDGDTDALLEDRGDDGLRTSHGSSRNMAEDDAPLLDRRNSTRLSRENEPSKKGGRLRLPSLRGPGFLQKATNRLRGNLEDQENKPPREILVGQYQTIKYPANVVSNAKYTPWSFLPRTLYNEFSFFFNIYFLLVALSQVIPILRIGYMSSYIAPLAFVVSISLGKEALDDIGRRRRDAEANAEEFTVVSLERSNAMEMTKKSRDLKVGDVLKVRKNQRLPADVVILKSVSNDSNLERERRASVEEPVPGPSTDLLNSPGPGSGPAEETSTTNTADASSGSDTFIRTDQLDGETDWKLRLPSVLSQALPLEDLTRLKITASSPDKRVNEFVGTIELGPPTGFYDAHIDKSTAPTNNIGAEDSETNSASLTIDNTAWANTVLASNTVTYAAIIYTGSQTRAALSTSASRSKVGLLEYEINNLTKILCALTLALSFVLVALEGFEPTNDKKWYVAIMIYLILFSTIIPMSLRVNLDMAKSVYGRFIQRDKDIPDTLVRTSTIPEDLGRIEYLLSDKTGTLTQNEMELKKIHVGTVSYANEAMDEVTSFIRQAFAGNALTTPSTVFGTQAGQAAAPRTRREIGSRVRDLVLALALCHNVTPTGEEEEDGRKVTNYQASSPDEIAIVRYTEDVGLKVAYRDRQTIVLESTESKQVVVRVKILDIFPFTSDSKRMGIIVQFEQSENILETGASAEPEIWFYQKGADTVMTSIVAANDWLDEETANMAREGLRTLVVGRKHLSLQQYQEFAGKFKQASLSLQSRDVGMAKVVSEYLERDLELLGVTGVEDRLQRDVKSSLELMRNAGIKIWMLTGDKVETARCVAISAKLVSRGQYIHTVSKVTDKSTAQEALDFLRNKTDCCLLIDGESLNLMLGEFRSAFIAVAVLLPAVIACRCSPTQKAEVANLIRQHTKKRVCCIGDGGNDVSMIQAADVGIGIVGKEGRQASLAADFSITQFHHLTKLLVWHGRNSYKRSAKLAQFIMHRGLIIAVCQTMYSIAGHFDPKGLFIDWLMIGYATVYTNAPVFSLVFDKDVDERLANLYPELYKELKTGKSLSYRSFFTWVMISVYQGAVIQGLSQILLHTITGPRLISVSFTALVLNELGMVAIAITTWHPVMIVCLLGTLLLYAGSIPFLGDYFNLRFVVTVDWLWRVFAVLAVSLIPVWAGKLIKQSWSPPSYRKVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM85</accession>
    <name>A0A1Q5UM85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM85"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="312" mass="36236" checksum="542895AF633B608B" modified="2017-04-12" version="1">MSLQSLPEEILLRILSYLPFHADAAALSSQCHRWHQLCDMSNRRKYRRVKLRETLDLAVALRMLRSILKTPQYGEYVRYIELNRSPSLDYSFYVRSYEIKPPQRSLRPKDRDRLTQAIKGAGFDSPEGQEKVLNVLLQSPATMEEYLLNESEDRSSRSHPAYQQEWADELQELPPEQSSRSLPGSLLGLPNVKNLSLGIHLLYYLSRGIGADQVDDASFAIVDHLPPKLEALCIYGYKKGMKPQVDSLPHDVFDRQIEKLLAEKDRKLPRLSYIEGIDEFIENATTIEQPETNDEDLWERETDDEWTDYEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMX7</accession>
    <name>A0A1Q5UMX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMX7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMX7"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="433" mass="49024" checksum="DCD925E59A6A9424" modified="2017-04-12" version="1">MADEPGQPPALTTLSLADKAPAAKAVGQVITPFDVSGGVDETGKLLPVDYDKLVREFGATPLTPDLLERFEKVTGHRPHRFMRRGVVFSHRELGKILDRHEKGQPFYLYTGRGPSSDSMHVGHTVPFEFTKWLQDVFDVPLVIMMTDDEKYMHSQKIEIEDAKRFTKANAKDIIAVGFDMKKTFIFSDFDFVGGAFYENICRMAKRITINQVRGTFGFNDSNNIGEFHFCATQSATAFATSFPQIFGTDRKKVSSIPCLIPCAIDQDPYFRQCREHAEKMKYKKPSLIHAIFLPALQGPGSKMSASVETSAIFMNDTPNKIKNKINKYAFSGGQETQELHRELGGNTKVDVPFQYLTFFLEDDDELERIRTAYEKGEMLTGELKQLCIAELQTYVKAFQERRALVTDEIVAEYMRPRPLEWKGNPNPVVAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNF7</accession>
    <name>A0A1Q5UNF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent urate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNF7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="32915" checksum="980D6DA30D93974E" modified="2017-04-12" version="1">MGSYSSPGWRELDVAVVGGGIGGMSAATALRRAGHKVSIYERTDSLDQAGASISCAANGTRWLHEWGVDVAKGDGVILQKLISRDWTTGKILTEYALDDYEERWGYLYYMFQRQCMHTMLKDSALGEGEGVPAKLLMNHKCKKIDINTGLIEFENGKMASHDLIIGADGIGSAVRTILDIRPEKRPAESSCLHANVLTEDAIAAGFTDFSKDNALQFWGGHGEVWDKIVLSPCRGGKLLSYYCFFPREKGDFQNHYWGEPDRSVEELLAPYPQLNAQVRGHLALGKDIQPWRLWMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNZ4</accession>
    <name>A0A1Q5UNZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000107">
        <property type="protein sequence ID" value="OKP14190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNZ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013135469" evidence="1">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="113" mass="11939" checksum="02B2905E5280ADA1" modified="2017-04-12" version="1">MHTLKYVLLAISGASLVFASAPPTLTKRASWVAAFYKLLQIRLPGKVVGSGERACSPVDGADCLNGSPDFRSGYMVCAYHGANCDGWRTGLGDSGLSGHAVIYENGYVQSIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP26</accession>
    <name>A0A1Q5UP26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_89</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP26"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP26"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF2">
        <property type="entry name" value="HYPOTHETICAL POLYSACCHARIDE DEACETYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="321"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="595" mass="65456" checksum="BCFB9E27332B9BC1" modified="2017-04-12" version="1">MSFLGIEGYHVFITGAAGGIGQEAVKEFLGQGCKVTGHDLRHVPTPASANNSNFYSVTGDISCEESVASCIKSAVDHFGPINILIANAGITDESSEYNIWEIPLDIWEKTYNTNIRGTFLTIKHFLQSAKEAQTAAGNTELENLAIVVTGSETGKFGQAGHTEYASGKAGLQYGLVRGVKNEIVKINSKARINAVAPGWVDTPLIAGRLDDPKEMWNEAQATVPLKKIAQPEDVARTMAFLASHRAAGHITGQCLSVDGGMEGRVIWRADEVLGKENTVVQAKSVNVNVPQPIVTKKRRIQILLSVDFDAVSGFLGTGASETNSLSDYSSGYFAAQVGVPRLLRLFKKHGISSSVTWFVPGHSMESFPNETKAIVESGAEVGCHGYAHEGAAQMTEEQEREVIIKCVQLATELTGQKPRGWRAPLYLLREHTVKVLEEFGFLYDTSLTHHDSALYFLPELPPIKPIDFSPSQSATTWMKPLAQPGPRTDKTLVEIPCNWYMEDMTPMQFIPAANNSHGFVSPTAIEENWKSRFEFLYNETEDFVFPLVLHPDTSGMAHVIGMIDRMITWLKQKGDEVEFVTFENCAKEWKAKQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPD6</accession>
    <name>A0A1Q5UPD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPD6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13031" checksum="52E0475986465D14" modified="2017-04-12" version="1">MPFAKGTNASSTPPRRMMFLKEHPDSGQRVMPSKPKRFTGDPCWQTLSYGVLLVPETHAYLKNFDTVVRTPSVPALALKNRPKASPYSIDTGYPHRHEQANQKNTSGPPEETLALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPS1</accession>
    <name>A0A1Q5UPS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calpain-like protease palB/RIM13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_14003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPS1"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="6">
        <location>
            <begin position="115"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="845" mass="93468" checksum="4F5839CE9C46DB8D" modified="2017-04-12" version="1">MSRPHGATLNSHVSQALQAEGAIASATSQKAALEAAINAAEYYMKALRIAPSDDKVQLDAKCKELITRAERIKAAADWQSAARQKPVSKLQPPTSKRKLTTREEIIVLEGAKLNGFIFPPWERAPTPVEFEQPFTDSPDLQISGCQTKIFAGWKRPFELLHAKNVATQTQDVEKPVMSVKGTSDLVQDVLTDCSVVASLCATTSRSERGLGEHASPAMYPRERGSDEPALSPSGKYIFCFYFNGAFRKVVIDDRLPSSNTQRSLHVIDRNHSNFLWPALVEKAYLKVRGGYDFPGSNSGTDLWVLTGWIPEQVFLHNEDATSEEIWGRLYQAFSYGDVVLTIGTGKLTEREQQGLGLVSEHDYAILNMKENNGRRQFLLKNPWAGAEPSIIQNGRLDPIHSENQPSPLSPGTFWMDCEQVFQNFENLYLNWNPGLFKYREDIHFTWDLTQGRALSGCFVRNPQFSVYSEGGGTVWLLLGKHFKTDDHNYLKHKGGALGFISIYIFQAGGKRVSLNDGALHRGPYVDSPNTLMRLEMPPRTTYTVVISEQSLPSSSQNFTLSAFSTSPVLLAPSRDKHMCLKKASGSWTILTAGGNAESARYSSNPQFSLEVSEKTDVSILLETEAELATHVKLFWSNGQRIARVRSRDIIADSGDYRRGCALAETKSLDKGLYTIVCSTFAPDQLGRFELWISSSIPCVVRPLASESAGRRRTVSSIGILTPGQDRMLAPLRVSRMTRIKLIAKSKSSTIESRSVAPSPVLMTVELGQGPYKKTLAVSEDGSHCDAPSGVRVDDFDLSPSPDSRGKIWIVIERIGGPGGQVEDHFEVEALAEERVEIGEWIVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQI4</accession>
    <name>A0A1Q5UQI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169:SF1">
        <property type="entry name" value="ACETATE KINASE EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="ETHANOLAMINE UTILIZATION PROTEIN EUTQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13056" checksum="0AEEA2CB1065D112" modified="2017-04-12" version="1">MVFQIKTKAEIFKIPNFGGIPNIYFADYLGTQQDTPSPITGSWFRIEKGPPSTPPKYDYDEVGVVIEGKITFKDATEQTAIVKAEDTFFFPRGSTITFSTDSYGVAWKCGARLQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQK8</accession>
    <name>A0A1Q5UQK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000070">
        <property type="protein sequence ID" value="OKP14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQK8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13439" checksum="0A344D03F63400C3" modified="2017-04-12" version="1">MESLLTGSGDSYRYGFSAVDPPLQTGSPSGRSSTDLLHDWPRGSRYVSSTDFEPHGLGVCMDKHYRIGGHCGRCVPLHHAMNTIGQWYQFFASPFASEYLSVWYSAESKEKELTSVNLGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQT6</accession>
    <name>A0A1Q5UQT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQT6"/>
    <dbReference type="OrthoDB" id="4227165at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="33748" checksum="6373951ADAE52073" modified="2017-04-12" version="1">MPDEPRRIIIEKSSTVRRRYQRSNKRFKFTASQLRRIEREEELERRAKAIKEKGEKRRANKKRKAEKEAKDREERKRLGLPDPNAPKIPASQPLLSAFLGVKPKQPVEEQPVTANADSTTTENEDGGDTEVDSAGGDTEAESDIFDDLDEDIIEQGFACLQDAGIPKEAGIPKVSDVLENRNPIIGNNVSAESLCSLKDDHCDDDEFSDCSVFDDADIIREADAIAASRPSQPPHTTIPLPTMSLAPPVSTMGQPRSSQHPKSLTPSIPSLGDSFRDDTADYLEDVFSRGCGDSFGELVQLGSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR49</accession>
    <name>A0A1Q5UR49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thiol oxidase</fullName>
            <ecNumber evidence="2">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000037">
        <property type="protein sequence ID" value="OKP14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR49"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="424"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="554" mass="61383" checksum="F47F2A18AF21CBE2" modified="2017-04-12" version="1">MSANTVASILLPRTRATRHNKNVILALISSTFCSNVYANPQHYRTSWPAAVQDRWAMLRDERVSQGHPLITTMADGNGGVQCGTPDEGQPMWFTQGGCSLASQDLTYVDMSGNTTVIRTAAKGDLIKLTCDDVYCPIPARLDCYEQPGICSSDEWCMIDIHERWGPWAMDRDGSTPQWEYCYGAADFVANSTDEALIASYNADCVASTVGDYGIKLGPKTEAWKPIRGRCVAFRKAEESCIGNPLEFGPFEDEFGLNYAREQNGWPFPRPLVCGPGLTCTGADFEVRPSTCVIQRPPNTCFDGPWWDSTECPRTESDAPKGGLTMNQVVEALRRVILLYPGEIASPGECAYWNRTSNVGVSVLATQHRIYNIAAALWPTQIFDEIPSFDEVMRLIPDPNLFGSPSDCVAQADSPGSDINKALASAATLSSQPNQVWSLVHFLMHNQVAPMSPKRVAASRSLAAHLSESFWCDDCRGFFSVGVIEVYGLPPLSTNPEDHAHWWWYGHNVASEHVASTRGGHPWIHELGERDVTSFQNPFFMTWKDAVDMWTYNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URZ8</accession>
    <name>A0A1Q5URZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000016">
        <property type="protein sequence ID" value="OKP15229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013338906" description="Hydrophobin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9578" checksum="01F3EF3BB5969B78" modified="2017-04-12" version="1">MKASIISVISFAIAVAALPPMEHSDKPGKHSIIKSREQCDGGKVSCCSPMKEDNENILLSLLDGLNVLGVKDSYCSPISVIGPLNLAILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMM1</accession>
    <name>A0A1Q5SMM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMM1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="6959" checksum="752CA3EBDC0E2786" modified="2017-04-12" version="1">MVPTTPLPRLYEVRVDHDDAIRPEEIADAMNKLLDHTKITSLHEDECISACEDAVNNNDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMN6</accession>
    <name>A0A1Q5SMN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="128" mass="14278" checksum="52A65E378D5FDBA5" modified="2017-04-12" version="1">MEIGQQDHAKVGGETADTDTSLTMDLCHAELARPPFVEIFERRSHQLTGNLIDPRPLPPWRTNAFAEIKLERDRETAREMAESTREISDVVVCSDAFVREGYLGAAIVTLNNDKAVIESRQVRVGPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMQ6</accession>
    <name>A0A1Q5SMQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMQ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMQ6"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="206"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="404" mass="42408" checksum="6F6A4B324B8B7984" modified="2017-04-12" version="1">MATTSQAPLRFTSHHNLVYRLVLSTLTGRTVHISQIRASSPTNPGLAPHEISFLRLLEAVTNGSQMEISYTGTILVYKPGLVTGSASGVGASGGVIRHELPSNCSRGLSYFLIPLCLLAPFSKAPLKVLFSGPGVITSSTPTGDMSVDSVRTAILPLYNQFGMFNNVELRILKRSNPGPNGRGGGGEVQFTFGHQIRLPKTLHLMNPGRIKRVRGVAYSIGVSGSNNARMIESARGILNPLSPDTYIFSDVSSAPLISVPDRNNANAKKKIGLGFGLSLVAESSTGCLFSADVASPPSGGEAPEDIGKKCAFQLLETISKGGCVPPAAATTMLTLMTMGSEDVGRLQVGREVIADPNMIQLARDLAKFGAPGWGIRDAAGENEDGDVIISVVGRGIGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMX0</accession>
    <name>A0A1Q5SMX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tip elongation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMX0"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="667" mass="73116" checksum="DA4F836CD9FF4CD9" modified="2017-04-12" version="1">MAAFDDIKVGDIVNVPGGMYGTVKYLGTVAGKPGRFAGIELGPEHSQRGKNSGDVEGRKYFATTVPGSGIFVPMNNSKYVTRRSASSSANTFTVPTTPGRPPPNFSKSMGPSPSMARPRIRRPSLPRPESPRTSVSPPKLSLGGLRTPSAASRTSGINGYPRSPVKAPSRLSDRPPSRISLDDDNASSYGRPSDFARPSSAETQELKDQIKSLEKQLLDRDKQLDEQSKTLSEFQKTMEELEGADAINIRTQLRERNERIAQLTAEFDGHRADFRSTLDTLEIAASETERVYEQRLDELMQQNNELQNRGEDVEIVAQQLKQLEELVSELEEGLEDARRGEAEARAEVEFLRGEVERTKLELKKERDQSATALKHAHAAADGPRGSYELEQKDDEIRGLKAIIHSLSRGNPGAAGLGENGSVDAHKEQSEQISQLEQRLQEFEGTTQSKDTRIEELERELQELRLGSGGRNRSSTVTLSPKQQHKPSSSSGNITVNHNINHAHRLSDRTVVPNDWHDMPTNDQRQHHRGFSNSSQPRLEPMPESERSSDDDALWCEICETGGHDILNCTSMFGSGNTGVNKPKSPAAPVEKPTEAPEDNAYANSHTDSAPSQKTGRDVVLEGLKGIGGLGSSMAPIAGKSSGVIDESKWCALCERDGHESIDCPFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNV9</accession>
    <name>A0A1Q5SNV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucan synthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNV9"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="157"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="529" mass="58572" checksum="164EE1F377AD5B65" modified="2017-04-12" version="1">MANAFGSAWRSFWHTMTSYDRHASHDSPYRTGRHVPLSQSRHEPLTSIATSAIESRPDLSSPYDDEPTKGLASAQATEWNGSPTEVGSPNRPYSPGMRSLASQKRGSNEQADGPPEIQMQSFHDGAPPPPPVAHSWRKIERWLEHNYEELLDNLGEGCTQNDINELEHELDCTLPLELRESLMIHDGQERPGLPTGVLFSCMLLDCEEIVQERRNWKTVNDEFLSHNAPLPAPVSSSAASSSSAAAQQQSNPGAWRNDLLDRQDSQPPGAVQKAYAHPAWIPVARDWGGNHIAIDLAPGPAGKWGQVIIFGRDYDCKYVIARSWAAFLAIFAEDLCSGKTYVEEETNEMKLREFKSQNVEPPYLEILRWRTDQKYGRRAPRRRAPNGLGVNGNGKSSSRDSPYGSPTRAEERGRSPHRFSKGPTQSPKTPFGVSSPLARVTEETSSPITTAGPTISEDPREHDKEAEQTEDLMEVATPQISNKENEGFPEKPTETKVPENEKSEKSDGTAEPSSVMDSEVLGEMKNVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQ04</accession>
    <name>A0A1Q5SQ04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000763">
        <property type="protein sequence ID" value="OKO90003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQ04"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="24780" checksum="77340E11A3DA39C0" modified="2017-04-12" version="1">MSGPDISHHIAGLIEVVEGIAEAYDPIKDLRGLPEAFQEVNKVLPLMEQTLRDAKSPAKKLKFSKEAKALETVLYSCDEKADKLLEIFKKIAKNSKDQYDSSVYRALVIKQGKRRVETLMDGILENLEALVSHHMFPTEIQMQVKLLADAREQLAKATPSLAESDLAEHPNSANQYGDNNRQYNLFSDGTQKIADGHYFEAQGNQNFSMMPSKESVERQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUG2</accession>
    <name>A0A1Q5SUG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUG2"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO91639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="358" mass="38259" checksum="A122618D60892A4A" modified="2017-04-12" version="1">MAPTSFPERLLKQWFPHTTTPFIANAPMLGFTDCRLAGAVTRAGGLGFIGGGFEFGPESTQLKNLDTRLTQARAELGTIASTRTLPLGIGFITFTPTGFEENAVAILEKHRVAAVWLSFPKSDADHQPLIEAIRKVQSKGHWDVKIFVQVGTVQAAKEALEQGVDVLVVQGVDAGGHQWAQGASLMSLLPEVRDLVANSARANEVAIMAAGGIVDGRGCVAALGLGADGIVMGTRFIATSECPAPLSMKESIIAATDGGVATVKTTRHDIFQSTDVFPRQYDGRAIIGISYNESQSGASDEDIIQRYNEAKEKGDDQRRTVWAGTGVGIIDKIVSVEELIKSIQQEANLAVARVMERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVA8</accession>
    <name>A0A1Q5SVA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dimethylglycine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVA8"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF193">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="429" mass="46160" checksum="97DB522F8DA0634F" modified="2017-04-12" version="1">MQSTLSIQDLNTNPSSKRIFIVGGGIVGAALAFYLSKADSDRHIILLDRSLKKSLGSTSHAPGFVGQLNESAVLTRLARDTVAEYLSVPGGFNTVGGLELASTEAGVQTLQSRCEKARAAGLSAEMISAEDAAALAPDFIDRETVRMGLYFPSDGTANAQLITSYYTQEARAKGVDFLEVDVVGFARKNGVIEAIRTADGDINLTGSTVILATGIWTSSLTGDKEVSITKFPVPIIPVAHPYTFTPPRPVRLGKPYPFVRWPEHHVYARDHGDHDGLGSYDHAPLELKPDQSAIGTWPSSFDKVLSEASSHLKNGGDFLVQGRQDDSDRFEEKKPFNGIFSVTPDNLPLAGRVSDVGNLWLCAAIWVTTAAGTAKLIAREVLRGSQEGISDSNVGVVKALDPARFQGVEGEVLTAQALERYNNIYNKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXD6</accession>
    <name>A0A1Q5SXD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12628</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXD6"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO92643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="729" mass="82050" checksum="FFB0A0DA13A61CF9" modified="2017-04-12" version="1">MIGDLENPASAPEHQVGLRRRQRRVQVARACDACRLRRTKCDNGVPCSKCIARGNHCSNSGALKASTLTEASEEIACLKRKVQELETELKRQASDHHNLPSPIGSSPSLHSDRLSTRADPGPGLKRYRDGIQFRPTRSSNETWFGPSSLYSFIQRLGEFLNLKLQKEHSVHRLHPVSASDHKLLDVPEAGLVGTQDRPLSRPTEDVFSAGIYLSLIQEEYFINLYWQTYHTSLFPIVDETQFKNHYQSLLVNGGQNRKPSALVDIIIAMCMQYATSTMPAETQGMLAEGKDALVAGRWHYWRGQKLLQYELDSPSLSTLQCHLLCAVYTCGGSFHNLMISTVGLAVSTAYMLGLHLDPPPTMPEKDREMRRRLWWAVYLMDSKSGMKLGRPFMLSSSYFMPSLPSDTLEAAASSGSMFTPIGQNATWLSYNLHTVQLYMKVRTAYTAFYDHESHLQERQALWPNHQAQNSGAEVLNAYAQSIHQWVDGIPESLKLKRQNNGQSSSTDFSSIVLEPFTPPWLQRQRLLLEHTYHHLCVNLYRPFISFTLKPLSDSISEELAMRCASHAIMLTMITHQALTESTLFDGWHEAFFCQWNAVMTLVGFVMLFPSSTLSYQAKHAIELAILVFDNFGAKFSVAANAAKIVRDLSVKIEVLTRSSDLEFNTATISQDFEVGSLSSVSVDQALPSQDLFDAPDFNLFDMAVDIDFWNSADTLWPDLENLSQFQAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXI3</accession>
    <name>A0A1Q5SXI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13285" checksum="C57225061E950016" modified="2017-04-12" version="1">MSTAIEKGDPIMPAISPSNSSHDHSLEMDDAKSRSHASSIAAADEEKSIPDMPIPLARQSTELGPAVKVPRSKRRGLFGQMTLVAEVEDPKTYPRRMKWFITFIVAVAGATAPMGSSIFFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYK4</accession>
    <name>A0A1Q5SYK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000728">
        <property type="protein sequence ID" value="OKO93074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="77" mass="9127" checksum="85A9837347475704" modified="2017-04-12" version="1">MLELRAIKICGIVGNPNAGMSTLARAYGTVQHQHHQHHQHHQHHQHHQHHQHHQHHQHHQHHQHHQHFNAISTSINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYR6</accession>
    <name>A0A1Q5SYR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000732">
        <property type="protein sequence ID" value="OKO93026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYR6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="10026" checksum="174C5BDBA40F7574" modified="2017-04-12" version="1">MDWRSFVGHFRGPRKAIGAKVAQPHAMGIDNNGDAFLITNEIQIPLKVADGMGIDAQRQDAVSDIADKSKWLISGSPCKGSYGQEICFTNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZA3</accession>
    <name>A0A1Q5SZA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_12424</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZA3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZA3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO93361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="152" mass="16861" checksum="1409E22C6AB87610" modified="2017-04-12" version="1">MVKLTEVEDEHFTDKPIPSKGDALLVSDDEEDYTDTESEISNEEEEDLELEEESLYERISALKDIIPPGARRTVSNSVSTITSLTKSSLSFSGKALWIISTSAFLIGVPWALAYAEEEQYIQMEREQGMIKGANEMLTPGAEPEKQGVQATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZQ5</accession>
    <name>A0A1Q5SZQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZQ5"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10817" checksum="2F85A23B7D0404B4" modified="2017-04-12" version="1">MVHKVLFWSGFGIAIRLWQLGIEMRPILAKESLWVYPLFAGVGGSFGYWMQGVENRQLKMLAQRREAILEKRRRRDEREGISKVEEGAVLAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0D8</accession>
    <name>A0A1Q5T0D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0D8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0D8"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="122"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="724" mass="79680" checksum="C884626B7DEF54C3" modified="2017-04-12" version="1">MDALHDALQCLLPTSWDEVPQSPDALREYVRDIFKSSRLVAESLPDPPPYDITEYKELESQAPNSKSRTRIVPSPARVGETDSGITSIQKQWGKPIKMGGPKDNPLGIHVWKLSSNDGKGSWFGRRSIHDGLPFSRWRKKLSSEYEETLKVNQRKIEKGQTPDNCIRGIGAEQKIESIEVKDEDGSVLGQVTVYHVSAQFPKPTAPRDFVAMIITSDVGLQVGGTKQPGRSWMMISKPCDHPDVPRRNGFTRGEYESVELIREIPRSSSNGASNEQAVEKSKEAEPNATSSSRANNHSNDALIKDGHDAADGDDEEINPVEWIMVTRSDPGGSIPRWMVDKGTPKSVGVDAAKFVNWAVEDDKPRKREKPSETAPIGTSRSPEIQPRDSTDNLNSDEDSLSDSDTDSVETDTQSHHGLIASVTGLLSSGLERFAPQAFFDYVPHQRTASGHLVDDTSVPEDELDKNSAPQPQSTVSSETKPRDPHLDQISLSSAHSGLGTPALDDLPQNNLPPAELMQIAKAGKLTSHEKDLAKLALRKREIDAKLETIRSELDKLHIPAQSNPSTPSRGVLNDIDSDTSGIQKRTPENSTSSPAASSQKTNGNNDSSSGDTPSSGRTQKAELPAHVHKAATELLHEESKLLKQLRKVEASQLKAASKIEARQRKEVERSEKSKSKSENETLRQEVKDLKKEISQLRSERQKWVDLVSSLQAENKRLAGKDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0V8</accession>
    <name>A0A1Q5T0V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Importin subunit beta-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_12085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0V8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0V8"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000201">
        <property type="entry name" value="Importin beta-3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO93806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121547" checksum="30E22DEC3EF07CA0" modified="2017-04-12" version="1">MSLLPQEVHTALSQLLRALSTPDNAVRSQAEEQLNNDWVQSKPDILLMGLAEQIAGAEDTLTRAFSAVLFRRISTKTRKDPISGDVKEVFLSLPNEQRVAIREKLVTSLTTEAVTDVRKKIGDAVAEVARQYTDNGDQWPELLGVLFQASQSGDSGLRETAFRIFTTTPGIIEKQHEEAVLAVFTKGFEDDNISVRIAAMEAFASMFRSINKKSQTKFFSLMPALLNILPPLKESSESEELSSAFLALIELAEISPRMFKGSFSDLVKFSISVIADKELSDQVRQNALELMATFADYAPNMCKKEANFAQEMVTQCLSLMTDVGVDDDDAEEWNASEDLEPEESDLNHIAGEQCMDRLANKLGGQAILQPAFSWIPRMMSSTAWRDRHAALMAISAISEGCRDLMTNELDQVLALVVPALRDSHPRVRYAGCNALGQMSTDFAGIMQEKYHGIVLNNIIPVLSSTEPRVQSHAAAALVNFCEEAERSILEPYLGDLLSRLLELLRSPKRYLQEQALSTIATIADSAETAFGQYYDTLMPLLLNVLKEEQGKEYRLLRAKAMECATLIALAVGKEKMGQDALNLVQILGHIQQNIVDADDPQSQYLLHCWGRMCRVLGRDFVPYLPGVMPPLLTVAAAKADIQLLDDEDQIEQVEQDEGWELVPLKGKVIGIKTSALEDKNTAIELITIYAQILEEAFEPYVLQTMETIAVPGLAFFFHDPVRVSAAKLVPQLLNSYKKAHGGNSPGFAEMWNKVAEKIIEVLSAEPTVDTLAEMYQCFYESVEVVGPNSLTPQHMQAFIDSAKSTLEDYQMRVKQRLEEQAELEEGDEENLDYEYAVEDDQNLLSDMNKAFHTIFKNQGTTFLPAWQQLMQFYDNFITSPDPTQRQWALCIMDDVLEFCSAESWTFKDHIMQPLASGLQDENAANRQAAAYGVGVAAQKGGAAWADFVAASIPSLFQVTQHPQNRTEEHVFATENASASIAKILHFNASKVQNPQEIVNNWIETLPITYDEEAAPYAYSFIVQLVDQQNPAVIAKADRVFGFIVQALDAGTLQGQTAARVAQAAKQLVAATNLNGESILAGVSPESQERVRKFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T206</accession>
    <name>A0A1Q5T206_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing factor cwf10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T206"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T206"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="153"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112622" checksum="549A880C1ACF8D2B" modified="2017-04-12" version="1">MDDLYDEFGNYIGEAESDEEQQEQVPQAFKFDEAFEDEEEEEEVNDQQLMEVDGTFCAPQNTQSKLDRMLIRASHTEGPSNAVILHEDKQYYPSAQQVYGADVETMVQEEDAQPLSEPIIAPVQQKKFAIAETELPPVYFSREFMSDLLNFPEQIRNVAVVGHLHHGKTAFMDMLVRQTHDLSARLEKRQGKRKEEQLRYTDVHFLERQRGVSIKSAPMSLVLQGTKGKSHLVNIIDTPGHVNFVDEVAASVRLADGVVLVVDVVEGVQANTEQIVKHAVLEDIPLTLVVNKMDRLILELKLPPNDAYFKLKHVIEEVNTLIENIVPGQGERRRLSPEKGNVAFASSSMNWCFTLESFARMYADTYPKLDSTEFAARLWGDIFFNPKSRKFTRKGVEENSKRAFVKFILEPIYKLYSHTLSESPEDLKQTLASVGVTLKPSQLKTDAAELLNLVCEQFFGAPTGFVDMIVQHVPSPVCGAERMLERYYTGPLDTKVATSMSTCDQDGPLVVHVTKLFSTVDASGFHSFGRILSGTARPGQQVRVLGEGYTPEDEEDMVIATISDTWIAETCYNISTDGVPAGNWVLLGGVDNSIVKTATLVPLKLEDDEEPYIFRPIRHMTESVFKVAVEPVNPSELPKMLDGLRKVNKSYPLISTKVEESGEHIVLGTGELYMDCVLHDLRRLYSEMEIKVSDPVTRFCETVVETSAIMCYSITPNKKNKITMIAEPLDEGIAEDIESGKVNIKDPIRKVARYFEDNYDWDKLAARSIWAFGPEEMGPNILQDDTLPSQVDKKLLGTVRDSITQGFSWGTREGPLCEEPIRNTKFRLTDVSLADQAIYRGGGQIIPTARRAVYSSFLMASPRLMEPIYSCTMTGPADAVASVYTVLSRRRGHVLSDGPIAGTPLYSVKGLIPVIDSFGFETDLRIHTQGQAMVSLVFDKWSVVPGDPLDREVKLKPLEVANAMSTARDFVLKTRRRKGLAEDVTVSKFLEPELWKGLQESGVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2M7</accession>
    <name>A0A1Q5T2M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_11662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2M7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2M7"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="726"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="458"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO94395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="775" mass="88252" checksum="42426F8D9CBCC99A" modified="2017-04-12" version="1">MSSPSSSLRKRGGKKETYTAVPSDDASLLPAVAAARKQSEWDYWLAMIVLTVLAFATRFYRIDYPNEVVFDEVHFGKFASYYLQRTYFFDVHPPFGKLLFAFMGWLIGYDGHFLFENIGDSYIDNNVPYLALRAMPATLGALTIPVVFLTMWESGYSLPACVLAAGLMVFDNAHIGEDRLILLDSTLVLSMALSVLCYVRFYKLRHQPFGRKWWKWLLLTGFCMSCVISTKYVGFFTFVTVGAAVLIDLWNLLDINRRQGALDMYTWVKHFAARLVALIIIPFFFYLFWFQVHFAVLTRSGPGDEFMSPEFQETLSDNAMTAQSVGVQYYDSITFRHKDTKTLLHSHWEKYPLRYDDGRISSQGQQVTGYPHNDTNNLWQIIPTKPLGEDAQSKSVRNGDVIQLLHVGTNSYLLTHDVASPYYPTNQEFTTVTPDLAEGERHNDTLFELKIENGKPAQEFRTFASLIKLVHVPTRVAMWTHTTPLPEWGFKQAEINGNKNILQSSNLWFAETIDGLAPDSPRLVREEREPKSLSFLRKYFELQGAMFHHNNALTSSHPYATEPFQWPFLLRGVSFWTKNETRGQIYFLGNPIGWWIASSLLAVFAGIVGADQLSLRRGVDALEEIWGPGARSRLYNSTGFLFLCWAAHYFPFWLMGRQRFLHHYLPSHLASTMVTGALIEFIFNLQPLDPATAAPPEDDPSGKAKANRSLGRFVTAKERMGRRSVIAGWIATLVILAFTIYGFVFFAPLTYGLPGLDVDGVNARKWLNYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4P6</accession>
    <name>A0A1Q5T4P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Brefeldin A resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4P6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4P6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="771" mass="86434" checksum="81235B33BBCF5A3B" modified="2017-04-12" version="1">MDVSMEKRVKDKIEEAHEQDEIERLVGDFVASQTGSSERLGDIVFRDLSVIGAGVGHELVNNVPEALNRLLKLVNPAAWWSRRPAPSRVLLRKMTGTVREGEMLMVVGRPGSGCTTALKAIANMREEYLAMEGNVWYGSFDAMTAKNTRPDQVAFVGEDDIHFPSLSVNTTLRFALNARHSTADPDRASHLEQDLKTVLQLMGLEQAAVVRIGNDHIRGISGGQRRRVSLAEAFCTRASLYCFDNPTRGLDSSTAIRFLNVLRKYTTRSRCATVMSLYQASDVAVSLFDKILVLNEGHIAYYGPASSAKGYFESLGFYCSPRISISDFLASMSGTPDGRTPQDALQRPVPLRPADFEVRFWESSFYQQAVDAAIAPQSTAVLPKPSGYALPFYRQIYECTVRHYQIFLTDRGTWIAEATGTIVQALLLGTLFRDQQDVTQGLYTRCSALFFCVLIMGLQASAEFGNTFVQRPILLKQKALRFYRPGAYALGQILADIPWKFIFILYSLPIYWMINFQRTAGHFFTWLVCLYLGLMALSVMFRAIAVFTNSPTRAVLPVGLLLNVFIMYTGFYIPPPGMKVWLSWIRYLDPMYYIFESIALNEIGDGNYQCSSDHIVPRGATYNDTTFQTCAVSGSVPGNLNLSGNLYILAEYGFKYIHKWRNVGINAAFFVFFAILVTIGMERFRNATERMSTIYYQKLPWTKTSTSDLADVEKLPVTTDLGGFDATSNDESSVSRLEAVQHVFAWQELSLELGDGKRLLHEVSGKNIREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q0</accession>
    <name>A0A1Q5T4Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="12930" checksum="3C5054F0CF663E32" modified="2017-04-12" version="1">MRAAFVAPSGVEACKRRGARIRNASETPISIGAQSVPKPARAELNFDPVRVRDDTLVPINAVRPKSGPCTPGKDSGFLSLVVLSRGPRKNASISYVLPDTVQSTLFARQSAEKRCIQELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q8</accession>
    <name>A0A1Q5T4Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4Q8"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13567" checksum="7E7402FBDECB2DCD" modified="2017-04-12" version="1">MDREGVGRYECAVWLEHISKQVDVSPSISRTENQDPEPWKVNFRGNATSYSIHLISELEVLRTAYQRFLPALGGPIALLPLPNNHATLVWSTTPENAAHLKFLPTPAFLAMVNAAFHMRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T647</accession>
    <name>A0A1Q5T647_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Nucleoporin NDC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_11212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T647"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T647"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO95700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="742" mass="82443" checksum="950778D138B854AD" modified="2017-04-12" version="1">MNSACIRTHRFGAHSCIRLCPSAHTVAGSAAAFYSPHSSYEAHPDDALSLVHCPPPPRVHPTQASTMAAATQPRPYRRILTSALHRRFVHASALSLLVCYVVSIAIGDKSSFFWTWFPIGPCGLRAVMIFLSVLLVFVLRVSQMHLGSRTTPSSLSTFKYLFPLQIAHTFCCYLFSAWWFTELYLWSSSKEAQLDIVKRGRYVNAYGIFPIGRLLITGSRSHERPLLNERPIYIHTYHLLLACAQATAHLYYDYDQISVPVTLRATKSTDQRTHQVLTPSKYIKSALPQRIKCGLMMSVIIAGATPFLYLLFLRQSAWSLSLYFAKLFWSFSRSAAQPDTFFPPSFGPLIIRSLISGSLLVLCWQSANLFFSIFLGKEPLKRGQPLTADAKEPNTSLLSGLKAKKHIVKAFALWELGLISQRQPDRRKAIFNEIDGDNGSTWSQILSCAKEEIQGITKRIEASKAPKPGAKPAGQPSGSKPELHTLPRLTDAPKDQNIFTTATKATSRHEKFGEAFGSTAKSYGQSPDWTPTARARAREVFDRASTAMLSPERKQKLLASTQELKRLTGGPSTTYKPEDVHPIIVQVLQWCPPLRQTYSQRASSIVFGTPDSSLGSIVDAVDSLTRMLIASLDEDQYGKVQTDVPSVVNLFTQTIMSLDAFVHQGGLDAHWTDVYFPPSSQPQAQAEARKVPEVELVLDTLQSGLCDLLEAFKPYLRDIGVTGKDLRLAREAAGIEEDEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T746</accession>
    <name>A0A1Q5T746_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T746"/>
    <dbReference type="OrthoDB" id="10643606at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="508" mass="56279" checksum="2D2609F1703A21E1" modified="2017-04-12" version="1">MPPAKDRPVGLLLDISRDDNDIHADLKLLQDKCDAFRTARDEPVVTAQIDAANCVKSAPEEIMSLPITTKAVDDMTAYALLTSRARTNCKVSATDFESNGMLRGKRPPRGKGVAIEAFGIRWIPEMCGRTLLTGTNLAKFPYLTRTERPKGSPPVISIGKVTIPQGWVEGTDYHVVAKPNIVNELPCPPAINDHKRGLYLKAMQASKIIIHMDLDLDHKVIVPSLTGEHAIMKFQDVPGFRKHCANPATGGPNMEIEDESLRPENALLHPWRPHDPMAPRVAKEKPKTKEKPKDAQPNTPLTPQEQRTDKTTREHKRQRLDTDSKESIYDVVAEKMGTKRALPCAVWSPDPMMAALFRELTSSTTGTLAGKLDKVSQCAGEINAYCKARNLTQEEAFGLCTTDKDFNKLALNFVNASNDCQAAIDQRARKNWRGAALANYVLANLQYSTIALRTEIRSPAIADIEAFLTRSDRNFAIPLKKDKAASKDGENDDIDDAKEDSPEPPEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8K1</accession>
    <name>A0A1Q5T8K1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T8K1"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="12"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="345"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1296" mass="140992" checksum="F7286CF51F1D9768" modified="2017-04-12" version="1">MATLAEKLEKIKSPKLQNQHHTAVVLSAVEDTLRDQKADFSATAYFAALLALLSQSLSAEQGIVNKDLATSVVYLLDITTTYVPAPILRSKFSQILTSLAPALSLPEVEAPLLRPSIGCLESLLIAQDAAAWNLPHTQIGPRRATAGLLSLSVDHRPKVRKRAQEALIKVLKTPPPSPSLDHPAADMCAESAMKTLGDSIQAASKQKKARHDANRDSHEPLIIHSLQLVKTIATASGGWPSKKIEALCELLMNASRSTNEYITMGAFEVFEVIFEGMADEFSSSKLPRLLDAISELKPAQNDSQLLPPWIAVLSRGYDVSAQINPEDTFTKLPELFQLISGFLASPSHNIRVSASECLISFLHNCLPDSVIVDASVYDEKTLEKLARSAADLLSVKYQAAWQEVFNVCSAMFDCFKWRSSPFLVDIVTTIGELRSNEAFHGKKEADSVLGSAIEAMGPEAVLELLPLNIMQQKNGQPGRVWMLPILRDHVTNTNLAHFRSEMVPLSEALYQKMMDYKSSEKPVETKIFETLVQQTWGVLPGYCELPLDLTEAFDQTFAELLSNVLYKQTELRVEICRALQNLVESNQAILTVEKDEDDLILQRRITKVAATKNIAHLAGFASNLLAVLFNVYSQTLPHHRGYILQCINAYLSITPETELNETFTRVTTMLESSLVEEQNPAAKQASSDKMPPTSHTLIDLVIAMSIYLPRSSFSGLFGMAAAVLNGSSPNPDQQLIKKAYKLIPRLASTETGRAALEERSGELQALMLATSDKTPASGRRDRMLAIDELVTNLPTSDLHFIPSILSEVVLGCKESNEKARTAAFDLLIHLARRTIDSERNPPGTVIRNSLVPHMPDDSPDAPATIEEFFTMVSAGLAGSSPHMVAASVTALSRLFFEFYKDLRSEILSDLVQTVELFLTSNNREIVRSVLGFVKVAVVILPDDALRPRLSALVPNLMAWNKEHKGRLRSKVKGIIDRLVRRFGAPLMENLVGEEDRKLVVNIRKQRERNKRKKKEGAADDDEEEEEDKAQGQQQSSNAFDKAVYGSDFSDSDDDDDDDASVIDVDTEGQARIKGKKKSAQGNQYIREMSPEDNPLDLLAPDALANISTTKPSLRFLNTGPGSKKKHAAKFDADGRLLLGDDQAADAEMSGTAQGGSGINAYLAAVSGPDAVRRGQKGKVKMGQAKKRGGDDMDIDDEEDVAAIGQDLRSKAQAQGRRGLGAPKTPGASGAGRIDKRNTRGGKTGRGGPRPGRGGGPGRGGFSSRGGAPRGPGRGPSRGFGRGRGGGGGVRGGGGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8P5</accession>
    <name>A0A1Q5T8P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8P5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8P5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="58392" checksum="F6FEAAAAA0771A1B" modified="2017-04-12" version="1">MPFYGRPSKNCQSCRERRIKCDRLDPVCSQCKRAGKPCGGYRDVPSLLFRDENDKTARRSAAAKAKSEARRKLLDSSDSSDESSENPTNKLGLSRWDYVAQPESPRMVMVPTMPAVVPSTLEEQGLRFFFNRFVSAVSGMAGDLPSEMETSPFLKAILVPSPLRDATISVGLAAMSNVSQDRALSLAAREKYVAAINVVRKAVQNPDQANANQTFHIIVMLSMYEMVCCSPNEIDSWTVHLDGLAALVKQAGFSDALRNTHPRPHLQYYLISIIRYFLVQGVIPSELHDWSPEQIPGPQPDQIPTVRLVDILIRFMKLDSSLRGHPDPDPRIAASSALLCDAELEAWEGQLPQKWKFSLKKSNDFQRTFNGTYMIYNDVWASRDLNHYFWARLMVNEMIVRHIIRLETPTLDDICQRQKALDTTSLMATYICAGAASQMGAFGCGLPSAGLTQLPPLNGVFMLMFPLAVAGRAAGAGDDVHEWVLETLRKIGRTMGIRRALEMIPTLKEIRERKMRELGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9E2</accession>
    <name>A0A1Q5T9E2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9E2"/>
    <dbReference type="OrthoDB" id="4361520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="91" mass="11007" checksum="09FC38848355329B" modified="2017-04-12" version="1">MPTGEERRQAVDRVLAENPYEDNPQLWIFMIWVCMIFRRNGRPDFLLVEELTGYPAEFLRDGFRRLSTHCDAILALTRWVLENEENWYEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9K6</accession>
    <name>A0A1Q5T9K6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional regulator of adherence 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9K6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9K6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="780" mass="87035" checksum="0A5DB63ADC5CCEB5" modified="2017-04-12" version="1">MAPSAPGTASNSPAKKTSAPEKKYKCQFCNRAFSRSEHRSRHERSHTKERPFKCLKCRSTFVRRDLLLRHDRTVHAKDGGIPLVAEGRRRGGNGGVQKPSSSSGPSKPSITIDPATLEQIEASSDGMVDLETAAMLMTDFQHKAAAAVNGQVSERSESLSPGRGSFDPYLSGNATLPQMPWDTLISPAETGSMSTLIDRHGPVGDVLMSHSLPMSGNSTPNALSPYPSMTGPVSPVNYRRSPGPSQALTLPKAPQIADEMERSLMVERVQSADTLGALPENFQIPATAALNRYLSTYFNLYHPHLPFLHQQSFKPTSAPTPLLLAVLSIGALYTFERDHAFMLHVGSKVLVNQFLQHKENFDSRKCPLWLMQSSLLNMVFESWSGDPKGLEWTCSIKSLLANMVAGNRYQLKLRTDARQTSQPSREEWIEDESCRRTYFAVYIFFGMLTLTFNHTPAMSFDEFDNLELPSSESLWNLDAADDETWRRSIAAASSMTVREAHDFLFQGEQTRYSAFATRVLINALFLQVWNHKRSFEALQDVVTEYKLRLALETWESSLDVCEPETIVVPLSTPQKGHPLIFNSMAVYRNTRARLEVDLKSIQEAMRYHSSYEVAAAMTVAREKVKRSQEMNKVVQQCFECIEIAAIQGINWVAKTSATNWSVEHPLCGLDLMVILSLWLYRLEHDDEPATEAELAIYNKVRNLFDDDAIDAFGKLSSTVARVWGNILDGVVVWGITKLMGESFKLHSQALVGYEDSLRVAKDQPIHAVPTKSLASVGTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBW8</accession>
    <name>A0A1Q5TBW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000687">
        <property type="protein sequence ID" value="OKO97714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBW8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="103" mass="11709" checksum="0CD6157989613B34" modified="2017-04-12" version="1">MLVLALPTALLSAFGLILAAYLRLVRERNGFRYSFVYIQFVRSLAILFLMGYIASNIYALRILFARLDDIPSGFVYYSMIYFGGLGLVIYGSMAVIYYAAQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCB5</accession>
    <name>A0A1Q5TCB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_9766</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCB5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="257"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="636"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="564"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO97840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="825" mass="89361" checksum="A9B16A9F1F430AE7" modified="2017-04-12" version="1">MESTPKSAKSHKRKRDVETSNATTPTPTKKHKKRESLPSAASPANNGSATKRRRLKDALQGSDTEKETRKASATSQEKRKKDRVGESGKKSKDGKGKSSGKDSQEDSEPAPVSSESGDENEAEESSEDEGKRRKSSNDKHAGILSKFERTKTAASAKAKKAKKETKEAVTPAEMNVEPVIAKGLEPLPQPENPPEVIEAPTYSSLPPWLANPLRTSANERAKFSDLGIKPDLLRILEQNNYKEAFAVQSTVIPLLLDGENNHPGDLCISAATGSGKTLSYVLPLVTSLTARPASRLRGLIVVPTRELVKQAREACELCASGSRLHIGSAVGNVAIKDEQKLLMRVDQVYNPATVAQRQKSGLRGNDWMDFSLEDCVSEAMDSNGFLPGYIQRAEPNVDILICTPGRLVDHIRYTKGFTLKHLEWLVIDEADRLLNESFQEWVDVVNGSLNSRQAPETFGPGGQLLSDLGLSIDIHAPRKVILSATMTRDITKLNSLRLDNPKMVIIGAESTTDAEDLSVPHPDAHFTLPPTLQEHIIAVDDASQKPLYLLRLLLSHIKIGGEENAAKKQVTASTESDADSTSSDDTSSDESSDESSDDETSSSGSDSDSDSDSSSGSDSDSSSDSSSDSSSEESSDSEDEVINIAPQAKSPRTTVLIFTKSSEAASRLSRLISLLHPPLANRVGTIIKSNKSSASRKTLAAYRRGRISVIVATDRASRGLDLQSLTHVINYDIPPSVTTYVHRVGRTARAGREGSAWSLIAHREGRWFANEIAASVEGHITRTASIDRVRVKLDTLKSLQSKYAAALDELEKEVKAGRARPAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCE8</accession>
    <name>A0A1Q5TCE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCE8"/>
    <dbReference type="OrthoDB" id="4369580at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012660046" evidence="1">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="344" mass="37253" checksum="9F0900962005EF49" modified="2017-04-12" version="1">MILSASVILLVGLTVELAAAAPPISQEDCDKLCQDKLNNLHAVGQLYDIHNGMGSCDDCIICIGEGGKYTDPNTGRRRCCDTKNQVFMNGPAGSKLGKCCDASQAYLVDTRAQKGDCCPATNHVYLWDAKSQSGSCCPSGTAYFDGHKCQPEIEPEPKPHTISCSPHGVCASSSKTTGLKQGHCYQLMDTKGRTLSLHRGGTDYILQNEYDDLYHFKVCASTTDCSPSDKEMTVNDKFFLQDEFGTWNVNGAGWIDNRCSDHLYFTQDAKSAGAFQAAPWCVDGKCGICLKSAVDACRGLEIVCPATNPGIGRYVNSNYCLPMFVKEVPCMSEVFGGEGFKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCQ7</accession>
    <name>A0A1Q5TCQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">L-arabinitol 4-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCQ7"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="207"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="389" mass="41501" checksum="8FE6A4C0990FBEFD" modified="2017-04-12" version="1">MAPSVLADQHEHAPVAVAAKSLDRKVITASHANPSLQVTADHKLKSVEAPIYAPGQGEVLVHIKATGICGSDIHFWKTGRIGSLVFEGDCIIGHEASGIVLQCGEGVSHLKPGDRVAVEPGVPCEHCFLCDDGRYNLCEDVKFAGVYPYHGTIQRYKVHPAKWLHKLPDNVTFAEGALLEPLSVVMHGIKTAGLSLGRGVVVCGAGPIGLIALAAARASGAHPIVITDLEPSRLAFAKDFVPSCITYQVDRTKDAEGNAQAIRALFGETEYVAPETVLECTGVESSVCTAAYAARRGGTVMVIGVGKAIMNNLPFMHISLAEIDLRFINRYRDTWPPAIQCLSGGILDLKKLVSHVFPLEKAEDALHLCADPQNGSIKVLVVDEEEASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD20</accession>
    <name>A0A1Q5TD20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000679">
        <property type="protein sequence ID" value="OKO98111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="13034" checksum="38289DE8242E1222" modified="2017-04-12" version="1" fragment="single">APATSASLTTEFEYILRHHSSLAAPIVGLLDLYLCLWKYYVVDSALKIRLKEEQRLLQRSIKWLTTECDVLRQCCNDQALELFGRRQAVAALNDXIXEVLKASEKRAFSVIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD63</accession>
    <name>A0A1Q5TD63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="115" mass="13182" checksum="5C6A61ECF8A0E83F" modified="2017-04-12" version="1">MAEYRGFHDPLETLSGTWAKQSVERSDIQNLLSANADPDMEAHMTDLQISLVKAELEMFQISLFGGELQMFDSTNFWEVIAREFSFQGRLRRNTSRGPLQLTGYIYHALIDSEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDD7</accession>
    <name>A0A1Q5TDD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein LSM12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDD7"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="2">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="248" mass="25995" checksum="C996FAA3F3F325B9" modified="2017-04-12" version="1">MAENKRQSSGAKGSQTSAGASTAGGMAANMVPLEAALSGAIGARVRITTAAPSASTFEGTLFTACPFTNLVAINTSPSAPTADAKQAQSGDYHVIPVSRIQAFQLLALPSSNSSDAPSFTDAQPSIQALDTRALKAREAKALGEAMDREARRGKGVTREAQDLFDAFSRTMPAHWNGPHIVVADAVSISPPYRVDDCRPLVAGNEAALARVRKVLEMERKKIELRNASATIGSTSTFTRHASDQRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDG4</accession>
    <name>A0A1Q5TDG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9358</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDG4"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="500" mass="55134" checksum="EE6FF23AA54DDFE4" modified="2017-04-12" version="1">MSADPQSEKIVEEKGPAPVNEDALDLPALDELPKGRWERAWPTIACGAGLFSDGYLNGVIGQVNTILGVLYPDTYSNSPASQNVSAIAFAGTVVGMLIFGYTSDHWSRKWSLMISTIILFVFAALCAGSYGLNGSQYGLFAALTAYRFFIGVGIGGEYPAGSVAAAENTGELKAGHRNRWFIMFTNFQIDFGFVVSALVPTILLLICTENHLRLVWRLSLGLGIIPPLSLLYLRLKLNEPEEFNRERMRKFPVWLIIKFYWFRLAVVSLIWFIYDFSSYSFGLYSSKWIGIITGDDAPLWKNFGWTTLTYMFYLPGSGLGAWVSDWIGPRHTLAIGVLLQGIVGFIMSGCYKWLATPENVGGFVVVYGIFLALGEFGPGNNLGLCAAKSSATAIRGQYYSYAAAIGKIGAFVGTYVLPIVQKNAPNEIRKGQDPFFVSSALCIFSAFLAFFLLPQINQDTITNEDARFREYLTQNGYDTSTMGNRDQITTRDAIAQDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFB9</accession>
    <name>A0A1Q5TFB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-40S ribosomal protein S27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFB9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="154" mass="17624" checksum="CB058061C085A2B2" modified="2017-04-12" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHKKTKLAILKYYKVDGDGKIERLRRECPAPECGAGVFMAAMHNRQYCGKCHLTYVFDESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFG8</accession>
    <name>A0A1Q5TFG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFG8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFG8"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="713" mass="79703" checksum="6223A0250CB06BCF" modified="2017-04-12" version="1">MPREKQKRGRRAEQKAQKEESKHQDDDALEAPSAKRMKPSNDTDETAEPSFAEGADYISLDVGEDQQVVEETGDVVNGDTPFYGLLDTDEQEYFSRASEMLEANQFHDAEERNLFVESVYQEANGKELKIACSQGCSRLMEKLISMSDVKQIRRIFGKFIGHFLHLVQHRFASHCCETLFIHAAPAVMQKTAKAPVKKSEDGEEESELSLADMFMSVIEELKENWGYLLTERFASHTIRVLLLVLAGEPVDVTSKDSVVASRKKERLGLPAAGAQEESGPTQKRSVPESFEPALKKIMGDMVSGLDDTYLRALATQPIGNPVLQVMLFLELSHFGKSSAKDPKSILRRLVPDESFEEGTDSATFIRGLLYDPVGSRLVETMVRYMPGKVFKNLYKNNIRDRIGSLARNSTAGYVVLRTLERLGKDDLQSAMDLIIPEVPGLIERSRLVVPKVLIERCVIRNVDTKPFAKALEEAYDADPTVRLRQMLRLDESTDQASPESEDEEMEDADGDDYKRRKQKAPAGGSSTSAAEKLHGSLLAQVMLTVPGPMSELVYSSLLAQSSETIVQLSKEATSSRVLQQALTLPTSTQQFRRQFIPRFQGHLVELAQDNSGSHVVDALWPASKDVFFVKERMAQELAQSEMILRDSFLGRAVWRNWSMDLYKRRRGEWTARAKGIEREATATEGSGERPKSKLELARERFAAKEAAAAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIU1</accession>
    <name>A0A1Q5TIU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000650">
        <property type="protein sequence ID" value="OKP00129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="476" mass="53936" checksum="BC1E0D599CFEFFF6" modified="2017-04-12" version="1">MVHSSSRYYYDTLELDTVRDNERHNECSQLEWPLTSDDQIWARRPIVIASYNVLVLATLNIIAIVGILIYLLVNSNTSTDSEFALYKNTRFKDCAAVVPDASNCSAILTTWMKESGSGHGAYYANLGRFYILGTQVTTENKVSYDWCQTVSCFNDYKVIPSSANDSAMGITALHGWWFVILSAWTTIWSLRKTSPWFHKKTRTKSCRGWRELGIIDWLAIVYHLCGPLVVWWVSFADSIISPVPWPTLSLISWLTTWGYSSLLQYHPYSCIFARVPRIARALPWIFGLLAILQCAATFYLAVTDESMTGGTKNIYDSYTCLAAQITTAPGTSTCSAEQICSKEWLFSAPYFNLPGDMGKGLPFGLCVTGLVIAIVAPAVIIMAKISINSEISFKRYYRKWSPLLCLSFLAIATILLIGLWYPIELGRSWNRRKADALVAYDVECNVVHVALSPWRFYLDVNRYARWLRVVRLWFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJG0</accession>
    <name>A0A1Q5TJG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_7818</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJG0"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.20:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP00361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="51764" checksum="73123F57A44D0FF4" modified="2017-04-12" version="1">MEDFSLQPSDLDRLNLIHVAGTKGKGSTSAFISSILSQYTQSEPGQSSPRLHKVGLFTSPHLRFARERIVIDNAPLSEEQFARYFFEVWDRLETAAKAAGEDPVSLSTKPQYFRYLTLMAFHTYMSEGVDAAIIECGIGGEYDCTNVIEQPKATAITSLGIDHTAMLGTTIEKIAWHKAGIIKSGARAFTAPQPPSAEQVLAERAAAKGTQLDVVSEHPELRPGTSHVKLGLAGDFQYTNASVAVAAAAEFLRKTGVANISENVMSEPLPAKFKTGLEETRLGGRCETRFEKNVAWYIDGGHTLESIRLAGQWFASRIHSDSSSELAAMKPRILIFNQQTRDSTALARALHETLAAALGSGTPFTHALFCTNITYKQAGFRPDLVSMNTNADDLELLRVQKSLATAWNEIDPKAETHVFGTIEEAVNFARDVAAQERKVVQKDEAPVMTFVTGSIHLVGGFLDVIETKPYEETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJW4</accession>
    <name>A0A1Q5TJW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ester hydrolase C11orf54-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_7958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJW4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="19"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP00501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="324" mass="35639" checksum="E7DE38A6B41918B3" modified="2017-04-12" version="1">MTVTTHPRDPPPLGELAAIIQRSLQANFASASVSVVECPDLRQPPFHLASSGLSGNPCIADVGGQPNLFPRPNFDAKFNLRSLAKDMQMTEGEGGFLIGAGAAPFHETGYNAELAVNLYTPPGPHAGNDDPDIDQVRNGSRIIQVNQDGSSCCEVIKSLDCGLMVNLFGSSGDTGPVLKITARTRTGEQNFTNCIRLGLADHYGDSRPISLGGVFILKAGKAKFHIMPDFPKEENLPFRDREQLEKEWLTYHDFEAPVICLTVMHSSDPERLGLRMEHTHCFEVERNRKGGHYHYDLQDGGEEVEYEAYLNVASTVYRIDRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK51</accession>
    <name>A0A1Q5TK51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK51"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="200" mass="22266" checksum="BC4373C1A0A03F13" modified="2017-04-12" version="1">MDNIHVYVRLRPQAAIALTFPPSQKVSRSTNICFSSFSYAVKSYQKIERAIESVSLGDNEKVGDYEGVKASTGTNKIASLVATINTVINKNIQLNKRVTSIEVKAQATSLSPGRGAAPYDVKASENRSTEFHQLVNIDNNPHRKRPSLPETKENPKKRRKDGSRGFQAGQRWARGEWSVRETDRAYVRVREGGCVSKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL29</accession>
    <name>A0A1Q5TL29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VMS1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_7490</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL29"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="230"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP00909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="646" mass="71534" checksum="A49999F63D1FC791" modified="2017-04-12" version="1">MGDSNRLEELLKRPLYVYDLPPELLATLSAKTASQPFAEQTQQAPEPSSKDLETAAQESAIATSTLCSLCKVTYLNVQEQRSHVRSDHHRFNIKAQLRGDAPLDEIQFAKAVGELDESISGSESSETEEEEAEGNGDTTLTALLKKQAKLSGANEKDTTTATGGSPKNPLFWFSSSGLPSNKSLGIYRAMFSDVEQDAPAHLVESLRKKQLAPVKARTNNAQGQKDLSASGPHIFMCMIGGGHFAAMVVSLAPEIHRKQGGVEDRQARVIAHKTFHRYTTRRKQGGSQSASDATRGAAHSAGSSLRRYNEVALEKDIRELLADWRQMIDSAELLFVRATGKTNRRILFEKYEGNVLKQHDPRLRGFPFNTRRATQGELMRSFKELTRVKVSEIDEAALAAAAEAAKQKEVAKPSTPRPQPQKPKLSKEEEAALLHTSQTQALIRRSKVPALMSYLSNNSIPSSFTFQPADSPQNFRCPTPLHLAANNNAPAVVNALLTRANSDPTVTNGEGRTPFELCGDRPTRDAFRIARHELGESKWDWTAAKVPAAISKTDADSRAERERKEAAEEETIRRKASLERLKKEDAKRVAEQISKSGGRTLGAVEKTAAEKRDEETRGMTAEMRMRLERERRARAAEERFRRMQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL49</accession>
    <name>A0A1Q5TL49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL49"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL49"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293406" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="140"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="808"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="956"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="915"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="956"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1136" mass="122901" checksum="1846DB79AC564AE3" modified="2017-04-12" version="1">MRWSLFSTLILVLLFGVALSAPAVDFAERNVDAFTTVEKRVEQDATPTATATDNTPSSTSTASTTGTQGAATTATATATTTTITGTAVSNTSHSTFVATTVPSIDGSTGSGSDSQDGTKQKYTGGLPLQPEITPAWGVGGIILLLLGAALAFIGIRKQWVHIFLSTAFLAALGVTVLIVYVLNPPVSNAIQGGYLVAAFFTGAVFGGLALVFREITEGLGCLLGGFCTGMWLLTVKSGGLLTDNGAKAGFIIAFTVGFWCLSFSHYTRSYGLILCTSISGATALALGIDCYSRAGLKEFWLYIWGLNTGMFPLGTNTYPVTRNIRVELAITVIVTVFGVIAQMRLWKVIKERRAKEETTRKEAEKRDEEAEAEVGRQLEEKNLRERTEWENMYGNGAGKAASMTETAVAEDSRRGSDGFESTTHENEKGESVEMKDMSAPENSAGSSDSGKNLETVEEVEGEALEEHQDGHPNQPEDQQAQNETENDGPTAARPVTMWPEPIPREDNSSEHGAVVGSEAGSPRSKRFSGRSLMNRLSWRSANGVNGPLSPKLNGKSESEEALVVQDDATSSVVGVVDDIASICSSVVSDGQAAEDEKATEETVTNNLASKNVLAEVTEAELNSQALRAAPTENDGQLASSLARHDKNGQGPTQRGNEFQIHQDDDTEEQVSTVETNNQDDSQPKKTENLVLQVQPKPQQAPPNQENVLENPSEEEHHEQTDQENHVPNFDQAEDEAEIDNPQPDAEHVERELDSVSQTKPLRKSRSARLDASTVKEIPEQTSMVINSFRTNEWAKHLANAELPELEPIQLDYETESSAETEEAAAPVNVDGLLQTPLTGLPPPIINNPEQIPTSPEQNGRRSQGSVAPPAVPKSKTQNNIYTMSGAISPPPMARNMSSASLLPQERDRKPGPIRSVSTPFLTITTPNQEPESSDSPKWSGPPPLLAVRENMVRNRMSSTSLRYDPYTSRNQSRLSLADPTVIASPPLSIPEEMDEQFGTDTVEDADDVPLSKRRAMLQRQSMQSPSTSSIQSIEPPRSPPQSPPDSGRSAAVMAAWRQSVRQDLSQRRDPLSHPPSPGLPTNSERPRALRASTQQTRESSAAQVENTIAERMQRGGMTDLHRQAMRRMQASANRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM87</accession>
    <name>A0A1Q5TM87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM87"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP01336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="477" mass="53463" checksum="C1F226ABF0F0364E" modified="2017-04-12" version="1">MAIDNSSVAAEADAPEKTIKPAEEFIGDADDFTMEAASDLSSDDSDEEDTTSDEEIFHPHRMTLSTFRRLLSCYPTTVEQVHRRKAMLKLQPKPEKGSKRKPEKKAGSASANLRGAMLLTKTEFNASEQKYIKEETEKFLNLDKWRYEDMPKTMGERRVKEEGKGEVLTKDDLITVMDWKTKHGIPRPTLMGMVKSNQDKNVIKCSSTAMAALSTKDPMLAPNEAFPKPSIDAFGPLRGVGVATASLILSIATATGDPKQQVPFYSDDVYLWLCLKDFPEPEYEEYEEEHTAEQEEQPDADADADADAETKDKKKTPRPPKFKLKRKISKFKCPNGELNVRYNIAEYRKLWDACWELRERLNRAVDLAYSSSSPSTSPSSSARISHNDIEKAAYVLRNIAVSGYLEGQDPEDILRTAAPQKTRVDAAMKAQKARADASGETAAGEKKLAAKKQTKKEKEEKRKIANGGRNVKRRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ34</accession>
    <name>A0A1Q5TQ34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ34"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF93">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP02343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="49384" checksum="28257BC394B91AB2" modified="2017-04-12" version="1">MLAGKGVRAVAVMWVMTFMSLILVPLRLYTRVYIVKALGLDDHVFNLAWVFLLLYTIFMTISGIYGFGQPITSLEMDLAVKAVYFEMVGQTFAVLGMAIAKLSLGIFLLRIVVKQWHRISIWISMVSLAVVSVLTAILFWIQKLPSESIYDPRVQGRLVVTVTPFSILLGSWCAAVDFYFALLPWIFIWKLNMKFKEKMSIAISLSLGFIACACGIIRTIDLGGLSSSNYTEDTVDLIIWSAVELAVTLICVGIPTVRPLYRVIVHGSNLEDSEGGYIKHNNSDQTSHIQMQNMAKNNTAFRAKEEGTTELYISRNNHSDEEILVGQHGKNGRGIPIRKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKDNSKEDWKEYYNFISKEKRLNYIPLDCLWSVDPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ35</accession>
    <name>A0A1Q5TQ35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ35"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="466" mass="50915" checksum="062604B0754A8A14" modified="2017-04-12" version="1">MAPLGQTIAVIDKSGKVVSTSKQLFGVFNQAKAAYKERKAHFNSERNAKIAEQQALQALATYKIDDSPSIASRRSHRSRSRHHSSRSQHGQSRSHYEQDLHSATGRPESHYRPSERLPRRHTHHELTVRDAARPMTARSKSDAHIDMDLAYGEAHPAALSRYSPPEPNVDDQKQLDGLVSRAQWLLEEAHCVQHSATATISHLQKNPDAMAAVALTLAEISNLASKMAPAALSAFKAAAPTVFALLSSPQFLIAAGLGLGVTVVMFGGYKIIKKIQSGNANAEKGEEEEESIRMEEMMELNMESESRVEMWRRGVADVEAESVGTSVDGEFITPRAAAMSGIDVTTARAQRDPRFKFDDDGSVASSRRSRRSRTSRAHTTAESRSGRPRRETEPVPASKAPSGFFVRSKAPSKVASKAPSNAPSRAPSKAPSKAPSKAGSQVSEKEKRPKEKKKKGPSRLRLMFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ50</accession>
    <name>A0A1Q5TQ50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_7113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ50"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP02349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="416" mass="46339" checksum="9C42E5713B41167B" modified="2017-04-12" version="1">MSKGKVCLAYSGGLDTSCILKYLIEDGYEVVCFMADVGQEEDFEAAREKALKIGALKCEIVDIRREFIEELCFPAIACNAVYENVYLLGTSLARPVIARAQIAVAQREGCFAVSHGCTGKGNDQVRFELAFYALQPNIKVIAPWRDPVFYERFVGRNDLLAYAAEKGIPVTSTKSKPWSMDENLAHCSYEAGILEDPNITPPADMWKLTQDPLTAPDQPEDFTLTFEKGVPVKLEYTEKGQQKTVTDSVDLFLTANAIARRNGVGRIDIVENRFIGIKSRGCYETPGLTCLRAAHIDLEGLVMDREVRALRDSFVTFNYSKLLYNGMYFSPEREFLEASITASQKSVNGVVRCRAYKGNMSVLGRYSETEKLYDMTESSMDEIGDFSPAETTGFINVSAIRLKKYGQMKAAAGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ54</accession>
    <name>A0A1Q5TQ54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General amino acid permease AGP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ54"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ54"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="76"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="329"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="523" mass="57590" checksum="CAEF4E4AF875F3DE" modified="2017-04-12" version="1">MSQNNEHVSHSAVTAAIQRAESPCDFPDPEGKLVKTFDKSVGIAEKDASGNRDTSIDGGFMKPTYDHTRRKLKPRHLQLIGIGGTIGTALYVQIGNNLRTSGPGSLAEMVTYLPISSPFIRFAGRYVDEALGVAAGYNFFIFEAALVPFEIVAISLIINYWTSVIPVAAMNVIVLILYTVLNVFAVKWYGEAEFWLSLGKVLLSIGLIFYTFIVMLGGNPLGDRFGFRYWNEPGAFNEYYKTGDTGRFLGFLSALIAASFTIAGPDYVSMAAGETINPRVVLPKAYNGVFYRLTAFFVLGVLCVGILVPYNDETMADAFDNDKPGAAASPAGNSYVYCASRSLYGLALEGKAPLFLTKCTKKGVPVYCVVVVLLIALLSFLQVSNGASVVLNWFVNLVTASQLINFSVVTFTYIRFKKALDAQGISRSTLPYRSWFQPYIAYIACTATTIMAFVGGYTVFLPGKWSIPTFLFSYTMIGLFPVLYFGWKIFHRTKFLKPEEVDLVSGLAEIEEYTRDFVQVPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TSJ6</accession>
    <name>A0A1Q5TSJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000619">
        <property type="protein sequence ID" value="OKP03203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TSJ6"/>
    <dbReference type="OrthoDB" id="4367412at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="115" mass="12551" checksum="7B22BAB657843ACB" modified="2017-04-12" version="1">MPWNTVLSELSQAVRNNVDKITKILPDNLTTRSNAVKTVDLSIDVHQDSKDPNKAVAKVQANAQAKDNAVKDYIKSGNKGGGHKGTHKNITRPRHDPRVTLTTRTATRTTEVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU87</accession>
    <name>A0A1Q5TU87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU87"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="172" mass="19602" checksum="7B8215BBF1FD5246" modified="2017-04-12" version="1">MRQEGTGLWLLNLPEFQHWLSAPKQVLICPGIPGAGKTVMSSIVIHFLNTTFRKDADVKVAFLFCSYQSQHVQKSDDLLSNLLRQLAYRNSGKLCSHVEDPYKERLAADWTALDHEKMTSALSHTARSYKKIFIVVDGLDEHLPSNPEERRQLLSELFKLQNDLPVSFALCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU99</accession>
    <name>A0A1Q5TU99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU99"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="280" mass="31414" checksum="E76324A5EFE48968" modified="2017-04-12" version="1">MIEVSLKLRQQYPQMAFSSCTRLSDVYIKDVEYSASIQTGELYEKAVGEQGFEQKLRALHGGLYPPSDIVIADDPFAEIAARTWIDEYAKLDRSQLLTMSYEGWLGQDPEVKDAVDNLNKKFLPNNISEPTQGAGTNEEQEQETDQILRSSDGGTDGDNNECDNGDDNNDNNSNGGDDDLSQDDENEDKRDEVSKGEDGGGSEHEEGGHEDSDHEDSKHNEIENEEIEHRGSEDEESEDEESEDEESEDEESEDEESEDEENTHHNRPRHSTRGTSSLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1P1</accession>
    <name>A0A1Q5U1P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1P1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68339" checksum="8F34718F8DB31DD7" modified="2017-04-12" version="1">MSCPPQLSRSEVSDSSDYGSDFTPDEEQLLNDLVTKAAAEHAPVQRDATPVSTPTPNQNLEDAITAPVAAKLADLDSLQPASLAEIVADIEDAVTNSPGVRLPKVLGREKPGSPWRLEHPGSSEGRERERERSAARELEWTRETQLAPTLDTRTPVERFRRPPNKAFSVTDLVSPAWCELQYWYTLTKHGRKRRTPAMKKGSVVHKTLEDEIYTTVPVEIKTKEDAWALRIWNVIQGLRMLREYGITRELEIWGVVDGELVNGVIDQLSYECPDSVLEATAAGFYEDAEKSRAALPEYQMSLSDFLLSSSQGGKRISDLADLEAPGEVPPVEENPAVYGLPRIYMTDVKTKASGSVPTVKSTSFRPTLLQLQLYYHMLNRLITSDDVTMDVLAARYNLDPEKPFTDAFISEVGGLHDEFFDAVSSPPFDVDDVPTPEGAVQATHGFGPASSPPYASQDSTGILLTHGTLHRLWSYMKEQLRHTFIPSFSPHEETVAPSIPSLTQPAMLEEYPTLLSPVLTARFLSSAPTTDLHPRLLGSRSFLFDPATMSSYLTDQMEWWRGQRNPQGVGIVEAWKCRICDFRDECSWRQERELDYATRNRRRRTSSLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Y5</accession>
    <name>A0A1Q5U1Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Y5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1Y5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF52">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32674" checksum="028E06A4B5687CBC" modified="2017-04-12" version="1">MKTIQELLAEKPNDSDPQPVQYVGTVEAYDKWAEVYDTDGNFLQRLDTIEMRLLLPIFLDRVYTRFQAQSGQLTLLDLGCGTGRNTIQLLEALAQYRRQNEKDITSPTKVDVVGLDASPGMLDVARSAIQTSTQREDLKSSPEVTLDTIDLRHPATVRAQLPASLQSSGAAGVISTLVLEHIPAKAFFEAASATMAPGGYLLVTNMHADMGMRSQAGFTDPQTGVKIRPTSYCHSVSEVLAAAEEAGFQVEDIVGQEGQGQDGVLERDVDEQLAEKLGVRAKKWVGIRVWFGVCFSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3T5</accession>
    <name>A0A1Q5U3T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3T5"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7565" checksum="4C5C2A704F9B2373" modified="2017-04-12" version="1">MIEPKSNGSDTEAQSRRLPSKAKVCENPTKDETRHALERAIRYLEHQPNGVAADEYRIVEGIMKGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3V1</accession>
    <name>A0A1Q5U3V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3V1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3V1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="6">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP07144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="157" mass="18027" checksum="32B5F4AC3AEC9660" modified="2017-04-12" version="1">MEPRSDFYTGPLVVLDFQSFYPSVMSFYPSVMIAYNYCYTTFLARAVRWRGRDKMGFLDYQQPPRLLELLKDSVNIAPNGMISSPKAVDTEKSQVDAALLKLLVRLMISAVSCDNLWVMDPMPQGLYERHFQEGLSVIDISSEEYQPHYDPPLAPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4X5</accession>
    <name>A0A1Q5U4X5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">28 kDa ribonucleoprotein, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4X5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4X5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF4">
        <property type="entry name" value="SC35-LIKE SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="32036" checksum="EC02E0AA19AF9F2A" modified="2017-04-12" version="1">MTDQKEHKNEDVEAATQPKPVSSNLGAQQQPHKKAAQAPRVKIPPNETVYIGNLFYDITAEDLRKHMEKYGTVLNTMITHDNRGLSKGFGYVQFNTIEEATAAVEGMHSTILEGRHVVVHYARTHFNYKRASYPPTETLFIGSLPLEMTDRDLQDLFHDVKNLIDVRIPVDRRSGMPRGFAHAEFLNTEAAMQAMEILAMKRPYGRKLGVSFAERKRVGMMKPRPEPVDQEQAKAEAEARRRDRARREAEEAEEAERALEEEIASEKEAKLEDVTPVEGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5V9</accession>
    <name>A0A1Q5U5V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5V9"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28464" checksum="1FB57080CA68DEE4" modified="2017-04-12" version="1">MYLRAVHAESSTKALFEFITANPLGIITTAIPSTTHHFLQSSHVPWVLDVYTDDPEAPVQGRLRGHMARQNPQSIAMMEACTNSGTTELQQDVMILFTSAHHHYVTPKFYTETKPDTGKVVPTWNYAAAQVYGKATIYFDSSVAETSEYLSQQIHDLSRMCETSVMGYTGKDGKPGPWSVSDAPERYIEIMKKNTIGIEVAIESIGGKFKMSQDKGQGDREGVIQGFSNLGSDVGTHIAELVKERGEMKEAEKNKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U801</accession>
    <name>A0A1Q5U801_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U801"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U801"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="46818" checksum="3D66434DF00B7812" modified="2017-04-12" version="1">MITANNEEHTRMRRLLTHAFSNKALKEQDQILHVYADMLIDKLAGIVRGSQHPVVDMTRWYNFTTFNLIGDLPFGEPFGCLSDNKYHCPKTSAQEAQGKFTSCIIKHGNGGRGLSLPEIDVNAGVFVLAGSETTAALLTGCTYYLLRHPEKYVRLVSEIRGAFAQISEIKLSALVELPYLNAVLTKILRIYSPIPFMLPRLVPQGGAVIDGQYVPDTIHLNSATERYPVTSYIPLPTSPSSIPKIQHDFPPESRPERKARVKKQKAIKEAFMHSWNGYKDHAWMRDEVSPQTGGYQDSFSGWGATLVDSLDALIIMGLDDELELALEALDRIDFTTTRSAEVNVFEIIIRYMGGFLAAHDLSHGKHPILLKKAEELGEMIFNAFDTHNRMPQMRWNWSKYFFPTRISRVVANYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U804</accession>
    <name>A0A1Q5U804_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U804"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U804"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="434"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="520" mass="60959" checksum="7E997ACDCFA845A5" modified="2017-04-12" version="1">MAIKTKSGLETGRLAWLGVQQHKVQKGQAYHPRYLHAVNPHSSTIVSLWGNKGKLTVQELLEKNLLRWVTSSKQPFTVLESPGFQQIFKDIPGATLPFTSRHTLRQRLLEDFDLQRTTLKEELEATCQTIALSLDVWTSKNHIPILGIVGHWLTEDFVYREKVLEFTELHEEAAAICDNLDNGEHHSFPAIEPLAKLRILALWIHRSPQRRQAWRNNCKRMNLSDKFIEYDVDTRWNSTFRMLEDALKSRQQLEKFIHYETDFPPFSTKDWTRLSQLYNVLSKFNEFTLFVSEKRPQISLAVPVYYELHDLLHDVAERKEDFADLDEDIASAVRESIKKYMKYYTFMDVSDIYYTALVLDPRVKGDLLLYELDTEDTGRNILQALRDDLHCKYPGTTEPLDMAEPLEPSYKKQKVGSRMLRRLQPQDRPRFSDIDRYFDSPRIDASDMEDQNWLCDWWRAHRKEYPRMAAAARDYLAIPASEVSVERLFNAGRDVLGVRRFSMKGETMRSLMLLDDAYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9Z7</accession>
    <name>A0A1Q5U9Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9Z7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9Z7"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="332" mass="35904" checksum="022D0D30CF37457A" modified="2017-04-12" version="1">MPFNTALTRKLGIRVPVVQGGMQWVGYAELASAVSNAGGLGLLTALTQPTPEDLRKEIRRCREMTKYPFGVNLTLLPAMVPPDYGAYAQVIIDEGIKIVETAGNNPGPVIKQLKKAGITILHKCTTIRHAKSAVKLGVDFLSIDGFECAGHVGEHDITNFILLSRARQDLGVPFIASGGFADGHGLAAALALGAEGINMGTRFMSTVEAPIHQNIKETIVKAQETDTALVLRRWKNTSRLFANKVTQDALKIEKESTTGDFAEIGPYVSGKRGRQVFLNGDPDYGVWTAGQVIGLIHDIPTCEVLLRRIEKEALESMTRARSLYSDAPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAS5</accession>
    <name>A0A1Q5UAS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional activator hacA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAS5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAS5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14710">
        <property type="entry name" value="bZIP_HAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000101">
        <property type="entry name" value="BZIP transcription factor HacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044280">
        <property type="entry name" value="Hac1/HY5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46714:SF6">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="80"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="52054" checksum="7A345B476598DAC9" modified="2017-04-12" version="1">MAETTSLRDLESLSASPEPEMPLTISPSDTSLDSPEPVDDDMKEDEKKPTKKRKSWGQELPVPKTNLPPRKRAKTEDEKEQRRIERVLRNRAAAQTSRERKRLEMEKLETEKIRMEQQNQFLLQRLQQMEAENTRLSQQVAQLSAEVRGSRSSTPVKAGSPVPNSSATTTSPTLTPTLFKQEGEELQMERIPFPTPSTITLDYSPTLKPSTLAEATTDVTQHPAAMLCSPDLQCPSAASKEQALSLSSTSNFQFTLATTLQLLFLTMTSVASSTVTFPLLRILHSLKTGSPLALSTAEIYQHFPLIHWLISTPSLSPSTVTGPSFRMRLLTRLLACSPALARPLRDATGRALQLAVREQIFSPQGTVSATSEGRSTWMSLLTMAWAIDSITSQSRRRGRAMGVASSSSLSMSTVKGAGIGKIQSRVSSSGRRRSYGKMGPSHQHQHQRSTRSSWSSSSTGTGETMSSVLLGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAV7</accession>
    <name>A0A1Q5UAV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAV7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7134" checksum="2096CB5B4E695810" modified="2017-04-12" version="1">MLDLSNRMVELNNRLLTVNGGLLELGKENFDENATVKVVTLVTLIYLPASLVSVSIGSSSALKLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB74</accession>
    <name>A0A1Q5UB74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Isovaleryl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_4988</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB74"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000021">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase IvdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000003">
        <property type="entry name" value="isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000004">
        <property type="entry name" value="Isovaleryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF18">
        <property type="entry name" value="ISOVALERYL-COENZYME A DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="15">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="13">
        <location>
            <begin position="271"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="412"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="431" mass="46677" checksum="A7052A61C7F8F9E1" modified="2017-04-12" version="1">MASITLPSLLRTSARSLRRSANLPAFAPAFARNLSTKHPAGFEPPTEEDLLELRERVQEFTRREISAEVAARTDELNEFPADMWKKLGDAGFLGITANEEYGGLGMGYQAHCVVMEEISRASGSIGLSYAAHSQLCVNQLSLNGSAEQKERFLPGLLSGDKIGALAMSEHSAGSDVVSMKTTAKEVDGGWVLNGTKMWITNGPDADFIVVYAKTEPEKGSKGISAFVVEKTFKGFSCARKLDKLGMRGSNTGELVFEDVFVPRENLLGELNKGVKVLMEGLDLERLVLSAGPLGIMQACLDLVLPYSHIRKQFGTPIAHNQLIQGKLADMYTKLAASRAYTYATAREVDNGAASPNPLVIRTQDCAGAILYAAERATECSLDAIQLMGGNGYINEIPAGRLLRDAKLYEIGAGTSEIRRMVIGRAFNKEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB78</accession>
    <name>A0A1Q5UB78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000469">
        <property type="protein sequence ID" value="OKP09735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB78"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB78"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="304" mass="34616" checksum="2540FE27B77909C0" modified="2017-04-12" version="1">MAACVSMSSGCQLKGDVLGSSEDSLSPHRQERHSEFAVLSALKDMPRARCRRKGRRQRHINSRAARALTQTRTPPPPSLQEPAMPTALRELYMLSGMPEGFVPYQAQHFILQTMQRCLEQNAFQFAQKWLVSESQALGWTCPEALELHIFFRVLAKQQRKVRSDTFQEICRTVKDWQDSISNIRHAAVHRLAQDRSLLIEMSHAAVGFSRDLGASSSAAKFHRLSSFLKKVLPKSEPRGFQPTHDVVSQASSQKARLVHLIDRLRLLPRPIKKVLLLVEEEFTLGVQHFLQDEFPMRLNAKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBT1</accession>
    <name>A0A1Q5UBT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol 2-dehydrogenase (NADP(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="26850" checksum="FCB8C10C9450BEC2" modified="2017-04-12" version="1">MAEIIQTKDFFLNTGAKIPAIGFGTWKAGPGEAAAAVQAAFEAGYRHFVRRAARKGAFTYGKEDRTVHDPDWDFIDTWREMEKLLATGKVKDIGVANFSTVNMSKLLGSCKVIPAVNQTEIQPLLPQKKLNALCQQHGIHQTAFGPLGGSGSTLHEDPIVNTIAKKRGCSSGNVLLSWGVRKGWSVIPKSTNPTRIASNLQKCFHMDDDETAQIDNLVTTLGGKRFNRPNWGTTVFHDDQEANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC31</accession>
    <name>A0A1Q5UC31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC31"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC31"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="254" mass="26535" checksum="442F912568ABDB2A" modified="2017-04-12" version="1">MASFSGKTALIVGGSHGIGFSTAQLLIKHGTKVLITGRSTAPIKAAHENLGDKAKVVPCDIRSIAAISDLVQTAKSYFGAGKSIDLLFINAGYAALEAFTQVSEESYRRHFDTNVFGTFFVAQKLAPMVKNGGSIVFTTSVSNQVGFPGMAIYSATKAAVQSFVQTIAAELASQQIRVNAVAPGFVKTPTMGVADSSPAELKEFEGKGAQTTPLGRIGEPEEIAKAVVFLAFEASFMTGSQLVLDGGLGSLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCM9</accession>
    <name>A0A1Q5UCM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000375">
        <property type="protein sequence ID" value="OKP10248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCM9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="20094" checksum="710C12D4E233D819" modified="2017-04-12" version="1">MLQSATSLDELLERARVHGVNLSDYPTGLFLTKSVLKRTHPEQWELREMGILSSSSGQTPSPGSWEYFEHLGQFSHSVQWHRYLTGNGMMCCYWLPWITKTHNGALCIVVFGGSGAFAEFSDQVKGASVISKVKKPGWRDVPPMEATHVLFVGPVFRVKSSIILQNHSAGAIRADYRLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDH1</accession>
    <name>A0A1Q5UDH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDH1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDH1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="212" mass="24301" checksum="61E9F3DC57942ED8" modified="2017-04-12" version="1">MPTVISESLVKKTAEPSVSSVLHETDSSDTDGPPLGKPQNERRFWFQRTREYDPDEIATLPSVFDDPETAKQYQPRADWENLHRFDPSARWTWGEEYSLIRKIDLRIMVFACVMFMALELDRSNLQQALTDNFLKDLHMNTNGNSTSTIGWYLHDSADFLARLQPWKYRLQACIPLCRAALSTGQQVGWPRPLDPHPDGSLVYSGHGSVWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDJ7</accession>
    <name>A0A1Q5UDJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 2A phosphatase-associated protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDJ7"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="354" mass="40340" checksum="88E0304036DA1457" modified="2017-04-12" version="1">MEESQSLRSLFTSAKDAKTALESRGDTNTESYRDAVNATIAKFHECQRQIGILSLFSSNESLDDMSTGDIQYMTLEYHLAELSQRGPSADREATLRRALEQYERFITRLDEYELLSAGDKKFFEQYMANPSTFTLAPLNDAAARRDIKVRRFREEKELKEKLEYLARNEARLQSDDDDTRRLYLAELQLYIHQSFQAMDLLVQELSMLSAMRNAPAPTQPTADDSRQRSNLGGANYSDRLDPSLSQLLGRGRNGPLLNSKGKPMQPFTLLDRRTQLQQGVFRSGHNLPTMTIEEYLDEEHRRGNVLQGGEQSGIKPEVDEDDFDKADEETMKARAWDEYVEANPKGSGNTLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDR5</accession>
    <name>A0A1Q5UDR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDR5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDR5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="75"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="22609" checksum="6CD72C3A7A6C5046" modified="2017-04-12" version="1">MPHWREEYLAALAVRDQREKANVALYDAYSDASPAAGRRSSVAPNESQRSGSPASGTVRKRQPSSEPGPSLTDLLKTTRADLSEAQRSRTDLQDQLNRLNIEAEKLRKKSNRDGRRLDTLESEKAILGKRLKDRDEELREKTKLLEDFQAELASLNLEFNMAEKKSKELQRENKELVDRWMARMGKEADAMNDAFKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE01</accession>
    <name>A0A1Q5UE01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="12652" checksum="4287ADBB498F1CBC" modified="2017-04-12" version="1">MPSQGAEEADRDRPHTPPSAPRPHAIWPELLEGVPLKSLGGDPILIHRDHAGALADRDSLRTGFDLAGSRNFGHRTSRIDILDKVSGGVIDTEDQNEWPSGTWLAAWDKVDKVGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE69</accession>
    <name>A0A1Q5UE69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter C11D3.06</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE69"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE69"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="54866" checksum="78344A8B2C94941F" modified="2017-04-12" version="1">MPHASEGSHGPALDEESNESIGTPPNEYTSLLPKPIDEEDANQVDHVWRRGNCKVTRTKLLLIEFWKLTTSSVPVILAYTLQMSLQTATVVIIGHSSPMNLAVSAFSMMFALVTGWMIALGGTTALDTLASSTFTGSGNKHDLGILLQRAFLVLGLLYIPVCILWAFSNAFFQALGQDPELSYQTSRFLTALIPGGLGYIYFETMKKFLQAQGIMRAGTYVLMITSPLNAGLCYYLCYTLDFGLLAGPIATGISYWMSFLLLVLYARFVAGSECWGGWSWAALENLGTFTRLAILGFFHVGTEWWAFEIVALVAGRLGTIPLATQSVIMTADGILNTIPFGLGVATSSRLGNRLGARNAKGASVTAHSSAALSVIYGALVLTVLMGTRDHFAKIFNSDPRVVELTAEIMPFVALFQIADGLNGSCGGSLRGMGRQHLGAAVNIVSYYCFALPLGIYLAFHGWGLKGLWIGQCVALYCAGTLEWILVALTNWETQVHRAFKRMDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEJ9</accession>
    <name>A0A1Q5UEJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEJ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEJ9"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="381"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="528" mass="58122" checksum="A15A75B80B7E7EBE" modified="2017-04-12" version="1">MTKTMSAMELRRYWINGDEIALIDVREEGPYAEAHPLFALSVPVSEIEKKLPPLVPRLSAPIVVYDNGEGYIDRAATRILALGYRDVAMLEGGLSSYSLVGEVYRDVNVPSKAFGELVESINHTPSLSAREVKNILESDIDVAILDARCFEEYNTMSIPQGRSCPGGELLYRVLEAVPSPETTIVVNCAGRTRSIVGTQSLINSRIPNKVVALRNGTIGWTLEGLELDTKKTERAPQPSLGASQKAREYAASWAEYVGVPMIEIDQLGQFIEESKDRALYLLDVRDPEEYALDHPVGFTNAPGGQLVQATDEWVGVRGARIVLYDTDGVRARMTASWLVQLGWEVYVLRELSVVPESLPVPKSLSWHYPKTGAIAIDKLRTLTGATIVDLARSPSYRKGHIPGACFASGPELARDLRTVSGDGPIVLTSPDGEIAAMNLEYVQGSVSRQILYLVGGTAAWVAAGEPLETEPRWLSQPIDVYKRPYEGTSNARKDMQGYLDWEYGLVAQLANDGVSRFHVVRDRRGEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEP2</accession>
    <name>A0A1Q5UEP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEP2"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="131" mass="14125" checksum="5DFE7C706C244F7B" modified="2017-04-12" version="1">MIQLKTLLTCIDNSGASVVECVNVLKKKRPATIGDRIVVVVQKQRAATSEGTSGTALANKVRRGDIRHAVVVRVKKELQRDDGTVVRFGDNACVLVNKAGDPIGTRMNGVVGQELRGKQWSKILSLAPVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEW7</accession>
    <name>A0A1Q5UEW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000006">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="237"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="377" mass="40787" checksum="A914E909D4F56FAC" modified="2017-04-12" version="1">MEGNMLLGGNADNGALQALAAVGQCRLMSLWDNLFSHLRVPVAQILLTRNDIADRTQYINAQNTFEQLFEMGVVPIVNENDTLAVSEIKFGDNDTLSAIAAATVKADYLFLMTDVDCLYTANPRTNPDAEPIEVVSDISLLEADVSSAGSALGTGGMSTKIVAAKLGTSAGVTTIITKSSKPGNVHDIVKYLQRLQENPDEQASDIPPPPLHTRFLPSDTPIQSVTFWLLHGLTPHGTLYIDQGAYDAILNHKASLLPAGVVGVEGHFAQQEAVRLVVAEKPSPDALDGDFIHHAQEPREVGRALVNYGSMEIALIKGHRSTHIESLLGWSESEYVALRENISFHPQESRSVTPCLTPALEEWKSPRSPRSPPNGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF81</accession>
    <name>A0A1Q5UF81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_3356</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MNBE01000298">
        <property type="protein sequence ID" value="OKP11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF81"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKP11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="374" mass="42836" checksum="3FF2ADEA45F3A739" modified="2017-04-12" version="1">MPGRVLPTFTPAEVESHNSAKSCFIAIGRNVYDVTEFVEDHPGGGDLILDHAGKDVAEIMKDEISHEHSEAAYEILMDYHVGFISSDASGKVKASGVDNEETDSQLVYEGTGMSREEDLSIDTDYSQDYKTHKFLDLNKPLFAQLWYSNFSKEFYLEQIHRPRHYKGGASAPLFGNFLEPLSKTAWYVVPLIWLPPVFYGTMVGAQGLGDPTVAAAYWIGGVCLWTLIEYLMHRFLFHVDNWLPDNRVGLTLHFLLHGIHHYLPMDRYRLVMPPTLFVILAAPFWKLAHAVFFYNWFAAVQVFCGGVFGYICYDLTHYFLHHRNLPLYYKELKKYHLQHHYADFENGFGVTSRFWDRVFGTELETPAPKGAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG74</accession>
    <name>A0A1Q5UG74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG74"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="380" mass="42773" checksum="35738F2DEDE5BCEE" modified="2017-04-12" version="1">MAPSLTETVALRAPTFSVPFKTDAGHNKENLIGYKYEKEAELKGTDKLPPASFPNYLPVWDNETERYPPLEQFEHYDHGKDADATFPDLLPKGQAEVDDITPFIGSEIHGVQLSKLSKAGKDQLALYVAQRRVVAFRDQDFASLPIQDAVEYAGYFGRHHIHQTSGAPKGFPEIHLVFRGADDRTGAKFLEQRTNTITWHSDVTFEKQPPGTTFLYVLDGPSTGGDTLFADMVQAYKRLSPEFQKRLHGLKAVHSGVEQVNASLNGGGIARRDPITSEHPIVRTHPVTGEKALYVNPQFTRYIVGYKKEESDYLLKFLYDHIALSQDLQARIRWKAGTVVVWDNRVACHSAVFDWEDGQRRHIARLTPQAEPPFETPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGA0</accession>
    <name>A0A1Q5UGA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Histone-lysine N-methyltransferase ash1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000037">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="396"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="453"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="585"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="833" mass="91666" checksum="4843A901A2DC5812" modified="2017-04-12" version="1">MARRNSKVSASATPAIADLPTNDQPDDTMSLDVPEQLLTPENSRSETSSNNENALVEEKSAPRRRSTRVARASLQATETLEATAVENEDAAASTSQAYVDSIAQAKRTRSSLRHSIAVMESSLQNGTLPEDDTIMTDSHPMAPDTPVSKSSQEPQIEDTATSLQQRNLRKRVEKALAEDTATPKAKEIPKSDSRSSVRRSTRLSIVDKASDLLDRANSVLGKRSRDLNEKGKEVGRRASLRLRTVAPVKEDAPAPALEPAAKKRRVSESDLFKLREKEAKTPSEEPAAPAPPPRYKPKRWLSHGLYTGQEPSDSPPKQRRSKNSAKTTTGPSQRRLLPMPMFTGSRMVSNGRDYVLPFDIFSPLPPGQPKPDEWRKTNKNVFVGDAASEWKANKKLELSTCMCEEDTGCDENCQNRYMFYECDSGNCRLGPECGNRNFNELKHRTKAGGKYNIGVEVIKTADRGYGVRSNRTFEPNQIIVEYTGEIITQFECERRMRSVYKNNECYYLMYFDQNMIIDATRGSIARFVNHSCEPNCRMEKWTVAGKPRMALFAGDRGIMTGEELSYDYNFEVVTHRLISPYSNKNVQQCRCGSDNCRGILGPRPKDKDQRAKLEEKTQAAEKGSKKVIGKKRKLAAAESTISQKGKKRKLLNPKSIKAGVKKVVAKATARGKAAAKKTTKASATSSRGKAAKDVKLPKVKAASRIKAAVRNGPRAKAKAAKTAKATAASSVKGTPPLKRPSPETKKKILARAKGTGRPSPKKSPAKAKKTEVQSPRKPAGRKAPTKSPVKARMPVSKARKSTTTSGPKVKRTFGGSVKKVAKSVVRTVRGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGF8</accession>
    <name>A0A1Q5UGF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGF8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGF8"/>
    <dbReference type="OrthoDB" id="5402929at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="216" mass="23512" checksum="50C710DBE85179A2" modified="2017-04-12" version="1">MSGHNLHNALLRPPIIQILRAQGFHSTRPSVLESLSELTGRYLMILASATAAHAANAHPEDPSPVLEDVYQALQDAGALRPQLREWEEEWAGEEDLRGLESLLGWITGPVHREIRRIAGFVPSEGDMVDSDAIEKEDFLTALKKKHSKTGEESRYAGTVLGKSADEHPVILEGGAPSIREWGTQIRSRAPVSPGASDTSGVSSAPSHLSEEDRMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHE1</accession>
    <name>A0A1Q5UHE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHE1"/>
    <dbReference type="OrthoDB" id="5350472at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="11899" checksum="7ABF3504D86D686C" modified="2017-04-12" version="1">MSPKDAQFTVPPGWTSNPSSPYYQEEWIGANSEGQLIARAYGLQPGQPVMEDNNGWHTIFLSSNKFYLWGRMNDEVEEFVSQDIREIASLISHSGLKKLARKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHK7</accession>
    <name>A0A1Q5UHK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHK7"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="340" mass="38439" checksum="214E36787EE8D067" modified="2017-04-12" version="1">MSTGSNGARRMVSLMRPSKLDSSVCRSCQESLGRRNYASAAAATSETTSTSSPIPSTSSATNPVYTINAGVVLSRPPQITRDLEPFEKAYHFYQKRLNERLALPFTKYFYFKRGTPADVDWKNKIKERRTPARDIGKYNAYDSDAWNDELLLGSKEAEPEYQVEALVQDAESTANATSQDTSKKEEIPRPFSRVTEADKKGDHKSLNRLLSRTLYLLVQSKEGYWKFPSLPIEGDETLREAAERTLSQTAGVNMNTWMVGFHPAGHHVYNNRKPHVDQATGATIHGEKTFFMKTRIMAGQADLSASKEQLKDFKWLSKDELPQYVLPQYYSNIKNMLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHW4</accession>
    <name>A0A1Q5UHW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHW4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010382228" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7137" checksum="87EE22C40D266EC4" modified="2017-04-12" version="1">MAILMHLALAGLPLPLQYTQAKDIQEALSDDIAGDATQESLLVENSQGFGTTLHVNHISPLKTPGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHZ5</accession>
    <name>A0A1Q5UHZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHZ5"/>
    <dbReference type="OrthoDB" id="4340327at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="22919" checksum="794A66F5BFCEA584" modified="2017-04-12" version="1">MASTGGRRQERLRFLAQEYLAAHPGPDELAPNVSLHNSLRRFLKGATYSKEILDDLIENTVYRLASMHEADYLREQLGLDCPSIFDTNALEIIHNKSSHSQLFSRTWTLLVNREIITKPFRISRFYSKPLRYLTLVLVTFARSWDMIEEWVDVMAAKKKGWYRFIYKVWLGNRVGSDEAIGVMDHAYAAVEAIKKIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI26</accession>
    <name>A0A1Q5UI26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein ZIC 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI26"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI26"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="55855" checksum="8E7C7F62B0E8C318" modified="2017-04-12" version="1">MTSQPQVGDFCLECRWEDLHIDTKAPEDSSVPPCEPQWDCTDVEHHTSLARCEVDETCCDEDACADDCHIDCGSICDGFVDCDASTVCSVANCDEDHCESTDPVCFEDHCCDSTADQDCTFESIFGLTTPLSLDTSSILPSAAMGHHPVGELGKPAEYTLPNMIDPCYQYDFLSSYQAHATHCDENVPNHLGCQDFRKDWEGMLTHQHQPIPQPADVNPADVFHMLGMCSDFAVCHDQNLPTHHHHHPHQQPDLNTIEQPKEDPLNCFHTGHHHVHSEFKNPNDLDIHVHGPHRNHHRCRAHHHHTHPYSPYSRHSRSSVSSHFMSSPRETPPPLERDISSVLTTPEFSAEDNELHVCKWVTSIHGIQAPCGATFADSGALQDHLVSAHMNTVDGAKGNGYYCCWQGCHRPDEPFSQKSKLQGHFLTHSNCEIPTGYSRIRITLINDELDKNFKCSVCGKTFARQATLDRHERSHRGDKPYKCKDCGKTFTDSSELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIR4</accession>
    <name>A0A1Q5UIR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIR4"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="191"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="466" mass="53460" checksum="B81905932DC944E1" modified="2017-04-12" version="1">MNPNYPWMRPRRRGLSFLCVIAIVSCLAILAIWYGMNSDRDYIHPILTQLLPAGHCACQTSTTFQCSTCVSCSESSTLQLSASPSWKFQYPRDARNEALDQTQCQAAFQGLFEDIARGERYWRGHDGGLVTEDLDDITIEPGMVRAFISQGHLHVVTARAKGEDHRRKILGVLSSIHRALAADRDRVSRRDIEFVFSVEDKVEDVTNPHHPVWVFARTPTEEGVWLMPDFSFWAWDNPQNYIGPFDQVVDRIKRVDLPWDEKRPQLVWRGKPSFAPKLRRALIEAARDKPWGDVKQVDWDTGSNILRMEDHCQYMFIAHVEGRSYSASLKYRQACKSVIVAHKLQYIQHHHYLLVASGPNQNYVEVDRDFSDLAKKIEPLVIDTDAAHRIATNSVKTFRERYLTAAAEACYWRALFDGYGSVWNSTVNPWSDRTGKERGLRYESFILLESPKMFEFTADAAMSGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ71</accession>
    <name>A0A1Q5UJ71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ71"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ71"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018839">
        <property type="entry name" value="Tscrpt-silencing_Clr2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10383">
        <property type="entry name" value="Clr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic loci regulator 2 C-terminal" evidence="2">
        <location>
            <begin position="387"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="79138" checksum="C7BAFF1C8F48EA1F" modified="2017-04-12" version="1">MSSDGDLSDDPNMVVIPVEDEKSDGQKSLWPVNSADSRFTYRIRDDESWRIGLAEMWVEKQMGAREEGITYILQKLPEGYALMDRPRGTDHKTRDSFLFGHPSGRYFQSRVTFFVHFYWLMTDRAQPCDCKLCAKVQTSSKPLGEFKPRKRRTKAEMEADRAKLEGNDKAIVKFSHRKLPGDEEGPDYWKIHIMDLKEKGTLDEEINHPLNLDWVLTHDALKDYFVRLPLQPAFVPRRGETVLWTSSLEGRLQYNPETQTVEMRAEDGKWLGMPDWRAGVVTQVSEEESSYLDIVQETKKKQPISYSGFRVETLPDPLADDKSYSLHYKYVPLKCIKPFGAFERFLWPTPREKLHPSIENAMTTMASYSLLHKVRFRGTWPSARIDCKGIFVGPELLAISDTVRLKPFGMKAEDTEDHQGEVKADLGPTVTDVMVIEQIWLQMDNCNADPDDTQLARKMVPYIAGKVYTRDPNRLNRVMPFDADPLEKLTPKEVEDSFSQGGMRVYGKWYRVAAGKICVVSPGMILGRCYEPEATHLHYGTFDLDYDLHGILSGRRYSVQVDARIPPGLDFFWGDSRVETLGLATMNGVEVGPAAEQRDDPVRWQAILRILQGSTSDIDVRLADLGISKGPGRPKKTFSEVRKMSKLVSTGLGAVTENEDSGEGPADAADSPSDMEISDTKLAAPIPFREPSEGAEYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ73</accession>
    <name>A0A1Q5UJ73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="148" mass="16656" checksum="53E47695CE2500DA" modified="2017-04-12" version="1">MSDYGGDNDAEENYDFEPQEEVFDENEPEDFIDHEGLEGDDGVEGESYEPAVNGENVVVSGDPNAGYSGKVMEQSREKKVPNDKRTTTPYLTKYERARVLGTRALQISMNAPVLVDLEGETDPLQIAMKELNQKKIPLIVRRYLPDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKC4</accession>
    <name>A0A1Q5UKC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKC4"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="450" mass="49501" checksum="8C9E3CB1B5E1FD44" modified="2017-04-12" version="1">MADLDKVCMGRSDPALAKALVEDSNSTIKWLASHGIRFHLSFNRQAYEVDGRLKFWGGLCLKTEDGGKSLIADYRAATERCKIDVSWSTTLVGIQQDPHSESYLVSVKIGEKDYVIQATAVILAAGGFEANARMRSQFLGPGWDLAKVRGTPYNTGDGLEVAMHQLGAQPVGNWSGCHSVAWDANADADTGDRIASNEYTKSGYPLGLMLNIDGRRFVDEGIDLRNYTYAKFGRAILQQPEHLAFQVWDSQMKPWLRSEEYREERVEHITAETLEELAEKCGHRGLRDKEAFVRTIKEYNQAVYAHRRENLSAKWDPTIKDGLSTQSSQKELAIAKSNWALPLDQAPYLAVKVTCGITFTFGGLKVDPQTAQLIDASTGRPIPGIFCVGEMLGGLFYSNYPGGSGLTSGAVFGRRAGKAASAHAVRARTGRSQQSESEEVFRITSSTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULF6</accession>
    <name>A0A1Q5ULF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000135">
        <property type="protein sequence ID" value="OKP13318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="32760" checksum="19B3EE936B0D81A7" modified="2017-04-12" version="1">MGGDITKFKDMLSSYKSTISIALAYANLRTTKTTRAVLEEYKNLIENTRCDLENHLQDIQEKLQIACAQGPVIAGLDTVELQLMEDEKSSTQKSLEICEQFLSLVDQSRPTLVGEVANSSGLFDKASSYRKHHYSWLINAEGLNSTSKEITSWKLRLLQHLYGVDRIVQGQQRYLPYLNNEREYEEQSFREELSGTERLLNLCKRIEEEEANRLRTHYFEDVTTGDNSRQAIVTTLDDLISAKRIKSGDNSLQALGNMADASIQSLFNSAVPDAGSKNQVKGKKKDVDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM01</accession>
    <name>A0A1Q5UM01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_664</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UM01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="641"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="886"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1314"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1322"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1344"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1368" mass="150006" checksum="8C48B77E1A156344" modified="2017-04-12" version="1">MATSRTSPLRPSIRLSPVHSRENSRSASPERNPASLYQKIDPLLSNLSPESTLHALTSTDAVPSNDNFSHNVLSQSISQVSPAERALGIRAAIAAQNLDIWYKEVQSWIWPKHREAKLGKGFLPPAETPSQANSVISSSLLLPTASGSCASADVEYYGSLPAAVVEEYEKRIDEIRDGMENLDVDELKEHVLNAHIPSRSRPSSSTSTVSVPPPLSYVQLSDFTAVVTATILRALPLLSRLNSLLTTWDVRLLVLRQVPGLLRELKATRASLDSSFHSLRISNPNENTDSRLSDSHLRTEHVDLESTVVAVGRRMDRALDALEGRQDSLPESWIDDLESIESDFAAWVVEAERYRLRTNWLRMKVQPKEPEPLASPEVLHEVLHEASSQPQIESLPEQATTAIEPEAPSGLESPRKTIEAHGENDPTPSPIGNQHPEEETETSITSSIEKDQALQASSDTIESSLDPCSETADTVLANAPKDQSPVRGNLIVTEDLQSPTRPAFSRNDAVDNSKQPSPSRVPLPVTPHSEDKENIPPPDYIQERPVSSSGSKPAALSEHNITDDDDPFVQKPVPSGETETIKTPSLFTAEVVPEPEVIKTPPSTRPMADSVCSIRDDAHEESPVIEHQSEPPREIVKQITTASNPSDTIWVTPRNPKPETHQIAPEEAELPKIDVFPAKAPNYTQDPCDPFQEFIRETTQKSEPVRPATSESRPTTAVALSREEKPPQEPVSTRKPLQSPIKLSKPRPGKLNLGEHAQRPRRHQRRSSTGSVGSLLSDNSSLISSPDAPEPQTGSSHDGPLITPSRQEFPQSDSIRSHGDHLLRADRLLQLENEKSPPAAFPQNRAVSLPLERFINDEFDLDIREQPELGATEFASSFKGHEVAKPPHAIVGHKTPAPRVPPRGSSQRPRLIRGKSASDLKESENFKKNVEHNRKAFGMNTAHRALLHQEQPKSVRLRQRLTAHPSLESLGVRRQELPYVEEDESELVDEGSRPSSPHRRRPRDHIDEKINSILSTLPGRIHLVDPNNEGDTSSSSSSMDRKMRDRGQSESPQVPSRSITPAPSLMLMPAARRRLSHAHKAEDSYVKLYHLHHGGQTAPTKLFVRTVGEDGQRVMVRVGGGWADLGEYLREYVIHHGRRKVSETPRVEVQGLGTRTSPGYPSPAAMLTSAAASPYITSGRATPSRPPSVMSARPQSSLTVRKRRGSNVSDALGPRSVTTGTLSSYISPPPVTLPGGRRLSMSSSYSFGGAHSPANIALASLTHDSQSTPLGLAGPKPRSRQISMSPEGEAWVEDVLQQTRRSSSVNPPSFALNVAPGTESVIDPHEADDHDLNRSHGRRSLPKVSSISDIRSVGSSKRVSLRGLGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM43</accession>
    <name>A0A1Q5UM43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM43"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM43"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="271" mass="28832" checksum="19B83CAD7015E060" modified="2017-04-12" version="1">MRSIVVTGGASGIGLGITRHFITQPDTHITILDVNATSGSQVLQQLQTEFPSGSVSFEQCDVSSWDSQATAFEKIYAEKGRIDIVFANAGISKEGNLLPAKGEAGPVKPNLTTMNVNLVGVIYTVNLATYYMYKNATSDPSASNGLIVCTASNAGLYPFPVAPLYGSTKSGVIGLVRSLARRLEQDKIRINALAPAVIETNIAPSADLFKPMIITPMSTATKAVAQFVADESLTGKIAEVHGEHVTFAEPPAYVDEDTGKNIETFWNLGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMN6</accession>
    <name>A0A1Q5UMN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar segregation protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="922" mass="99629" checksum="9EBFD81B66670F10" modified="2017-04-12" version="1">MAAESERPPYLNGASGSKGAKESEAASETGHRLARGSNDMIEVPRPTIQTQGQAMSQVPKLLPNLPTYSAPTSTGNSAVSSRESSPVRISSRTANSPSTSRVSSQTRKGTPDRVSPTRASSNGQSSTRTLQSSSGQRASPGPPTNPPPTLSPPPAPEAPANVPSPEKHNMPSWAGNRRTDQESTPSNTSLKRTSPSPSEEHGKTDRSTPRAATRVIVGQGPSLETVQEMASNPSTPSSDNALQPTTPDDVRLHTIDEDPTPRASRQNTESDNDSGGNPSSKEENRAHTTGTVKMPGTIMPQRSSTSLSAGARAKPTDGSVRNMIVETETVSSIPQVSLGVATGERGSSSRAEQGTLRMKPSTETIRPRKEKKKSRRANHLTTGPGTSKADIFEAKVASAVDEADVSDSDETFVYESNPPDPYPPRQSRYHSRTPSATSMASQVDQLAGRARGAMRDGSHSVTGKRSMKFTNNTYNSSMDGDAQEADGSRNAGRVEGSGTITPRHHHVGRHGRNGAYPSLFDNDGPFPQPQNQLKSPRHFIGSGYRHSRNSNTRSSPNYKTIANKKAGDVYDFDAEGADDERTPLVGTTRATRSRHGRRPNSASLRQMEYMAERQRDCFSRYGSCAIILFLLLIVAGGAASFIAAATKTLLDVQVVAIQNVLASEQEIMLDLQVEAVNPNIFPVTIDDTDVNIFAKSRYVGTESSWQENSSDAELYRTPRVEQSRRRWYLSQLVRCLGDTECVEEAMKGHSKGHSDGGIDKGTDPISDPEGDPQTMLLGRVFRFDSPLSFEASPWGHLVSTSKGQIRLARPGNKTESGGTERWERVLQHPFDLIVRGVVKYQLPLSSRFHSASISSTVRVIPDDDDDAHKPDSPDSTPPSNETVPHLSLVRRTTTPSSSIRLIADPDAQPEHQPGVSQRQFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN12</accession>
    <name>A0A1Q5UN12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN12"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9676" checksum="53ED21AE76AF965F" modified="2017-04-12" version="1">MPAEIQATSGGTEQAGRQLSGLWHRDIVAQHREDDRHGHICFCRRCGSVIYREAKVDEFRGLVFVPVGSLDDIDSVSELKDEEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNQ1</accession>
    <name>A0A1Q5UNQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal peptide peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNQ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNQ1"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="71677" checksum="8E801C2D43FE9279" modified="2017-04-12" version="1">MSEEISPLAELLGLAVYHFERLKPLLPTYGHLLIAALFPIWIGAHASLSRPSSAAKAPKKDDEKDGNYTDDDGSDDESGSVQKMEGLEPSDALMFPLTAGLTLGGLYLVIKWLEDPAILNKILSYYFSWMGVFFAIAFLRDTFSIVRSFVFPRRYHSGGKIWHAKQSERIFVAQSVNRSEVTTHIRHSPLPGIFGAIPVPKPVLALLWASRHVFYQRLRLRAHIRGLFDVKTFVGLLDLLSGLFALAAVGYFAFVTKPWWLTNFLGFSFSYGALQFMSPSTFWTGSLILGSLFFYDIYFVFFTPLMVTVATKLDVPIKLLFPRPPSPGQESDVQSLAMLGLGDIVIPGMMIGLALRFDLFLYYRQKGIQQAQLQGLSDKTTKPQYQRATGAWGERFWAPAVRPQVPEFKPPYSDARSFSKVYFKASVFGYVVGMITTLLAMQYSNHAQPALLYLVPGVLISLWGTAFFRGETSIMWDFSDAEEEDEEGEGEDKKEGSDKEKSDDTAPQEQKNFFARLMSGDLKLFTPGPKDAASKESQKENGKDLDDKNGNREGDAETDKSKEADSKKQREKDLKGQGGLDLISFSISFPEKTQKKASPDSAERSATEKDSMVTIPDIGDWNDDEPPLKKRRGTPRKAAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP37</accession>
    <name>A0A1Q5UP37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xyloglucan-specific endo-beta-1,4-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Xyloglucanase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Xyloglucanendohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>xyloglucan + H2O = xyloglucan oligosaccharides.</text>
            <dbReference type="EC" id="3.2.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.151" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP37"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP37"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033946">
        <property type="term" value="F:xyloglucan-specific endo-beta-1,4-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013225426" description="xyloglucan-specific endo-beta-1,4-glucanase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="26255" checksum="EA9F36D1AE3F6688" modified="2017-04-12" version="1">MKSFAPLSLVSLALAGLSNAATIPTKSLTRRADFCDQWGSTTTGSYIVYNDLWGQSYDTSGTQCTGVDSLSGTTIAWHTSYSWSGASNQVKSFANVALQFTAKTLSSISSIKSSWKWSYSTTSIVADVAYDMFLSSSASGSNEYEIMVWLAALGGAGPISSTGSAIATTTINGVTWKLYKGPNGSMTVYSFVAESTVTSFSGDMLAFFTYLIKNQGLSSSLYLVDVQAGTEPFTGTAKLTTSSYSAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPE2</accession>
    <name>A0A1Q5UPE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPE2"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="31762" checksum="AD4E615726D269BB" modified="2017-04-12" version="1">MQPFISVDGVVNFRDIGGYVCRNPAGLSSLPSNVDETPEKQWCIRPGFVFRAAQPSQITPAGIEILKKTLAIQAIFDFRSESEIQLVSKRYPDSLLDIPGTTRHAVPVFQEGDYSPISLAKRYGVTADESTNDQSFRPGFVKAYEAIARNAAQAGSFRAIIQHILQDSAGPVLFHCTVGKDRTGVFSALILKLCGVADEDIVADYALTTQGLGVWREHLIQRLLQRGEATTKEQAEAIISSDPRDMKAFLSNVVEGEFGGARNYFVNLCGLPEGEVDRVITKLVVPKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ24</accession>
    <name>A0A1Q5UQ24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ24"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ24"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="15914" checksum="990AA213666057F4" modified="2017-04-12" version="1">MKDFDGWTPLAWAAFMGHEAVIKLLLEARVDVHSVDSEGSTPLSWAVSEGNEAAMKLLQEAEQVSGQRQEYGGLLGGLGDTLGKTVGGVTNTLGDTVGGLGNTVGGVTSGLGDTVSGATEGLGNTTKGVGQGVGQGISSGSKSIGGQKQTAENPLGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQD7</accession>
    <name>A0A1Q5UQD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQD7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="29061" checksum="4B962C8D877E39F1" modified="2017-04-12" version="1">MDIDNVCLNNIHASILVGNLCGAEGESVSEGLFFDASEDAITQEIKDDHHRLPILGTLFWSLKPGQAIGQDDQPTLGLWGYMVILARIFGKIQDLHQKLSNGVLDEHHAELITQDLAQELETFEQGLPPDLHFTVHNLKKHARVGLGQVFVALHLGHHHYATLLYFPFFDIQLSQTRSRALFVSRCKHHATMSSDLLRTSHETPDCEAVYLIVAHMTMDSQLRLQHVLPIDGEPDIPATSDLAERGKVASDALSILRRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQV3</accession>
    <name>A0A1Q5UQV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000057">
        <property type="protein sequence ID" value="OKP14853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQV3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="172" mass="19359" checksum="00384D222DB43129" modified="2017-04-12" version="1">MDTSNTNPVEEHPEIQPGSGHSPIGEAIPHITEHPQIEADPPSGPAIPGNPERPSLGDQPFAPAMEALARLEHEDPKLAFQAARIVGLYRRLWESCIAKHMEGNKLAKANDALKETHRKLLDEKNRMQSCHDDQIARLRFFDQALESSRLRLTDILKEWNRYSDGLESKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR76</accession>
    <name>A0A1Q5UR76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000037">
        <property type="protein sequence ID" value="OKP14959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="3">
        <location>
            <begin position="241"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="36113" checksum="819D3508E0F0187B" modified="2017-04-12" version="1">MSLENPLTILYKEVDGSKITTDLYLPSNTSASPQKYPVVINIHGGAFMLGHSRMVSLPQVNDCLERGWIVLVPNHRLCPGVNMLEGPMQDIRDLLTWVYHGHLDAVLKEQGAYRADLENVAAFGTSSGGHLALGLGFDVPKPAKAILSLYGTVHFTDPLWTKPLPHVAAKLPPNLSEAFLNKVYDQKPVPTDSSVSLEGQTESGVSKGPDFSKPRDAFAFTQIASGTVLSAIYPESQSSDPEFKKVDPVQNVSSSFPPTYIVHGQADTMVPIELSRELLKRLQGAGVKCGMTEVPNEEHTFAAMMKVGSETWWLQRQGFDFLEGIIGKGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPR2</accession>
    <name>A0A1Q5SPR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000765">
        <property type="protein sequence ID" value="OKO89962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="109" mass="12235" checksum="58F4AA073919FCA0" modified="2017-04-12" version="1">MAQYDRKAAEHRCRKLFRDYKKWYDSLKGENSSSDSAGSPDSAGSSKPAGSSRTKLGSTPTEHDRASSPAAKPESRRNRRVRFEPIERSRSPEPTQFSRNDQTQSVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQY0</accession>
    <name>A0A1Q5SQY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQY0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14290" checksum="F22F9F1551D4E95D" modified="2017-04-12" version="1">MSEEDWDSVLRNTQFLNGHRMVFTTYANGTKGFKRIDKAPYTGHFFSTNIQLGGKLYASEQFTSSESASAEEKSNAMKASAQASFSYGTFQASASVSYEENGKSSGSNQTSKMSNSLTWEAQGGDTILCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRG9</accession>
    <name>A0A1Q5SRG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRG9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRG9"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="138"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="427" mass="47133" checksum="134725AD791AE4DB" modified="2017-04-12" version="1">MGSASSNKNFTVTIVGGGIGGLTLAVGLLRRNLSVRIFEAASAFTEIGLGLSIGPAAHRAMPLIDPQIREIYDSLVTTHADSPGYESYAQTWFEVVWASGVHEGDLLMNLKALPSGQTTLRRANFLEALVNLIPPDIVQFDKRLEKLEETADGVNLYFDDGTMAIADVVVGCDGIKSKVKEFMLPEESKTKQPQYSGMYGYRAVFDMDEMVQAVGDQRARVSTMYIGDGAYGISYPIMRAQKVNVGLYILNDTWDCDTWVRPAKKEDMLLDASKMGRYWKSLVEHMPDPSQWAVFEHPALSTYSRSRVAILGDAAHASTPHQGAGAGQAIEDALVLAELFGDSTVRSVSDVKAAFKAYDDVRRPRSQRVATSSKEGAYLLCLCLDGVGDNVEKLKEAFQERLRWLWDLDVQAHIDEAKHKMAEHMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK2</accession>
    <name>A0A1Q5SRK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="136" mass="14886" checksum="D5EB02FADC1059B2" modified="2017-04-12" version="1">MDPRLTHVFTLRAHVAQDSVQLGSNPTGSQKNITALEGGIFHGVPNTRGEGVDATLVPGGSDWVLFDPATNVVQIDVRTQGKLSDGSGLSLQYTGYMMVDEQAKRFMAPQFKWTESTVFVGRGRCCFEDGQQMVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK7</accession>
    <name>A0A1Q5SRK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nineteen complex-related protein 2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK7"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="321"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO90628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44722" checksum="4B1542D1C88C93ED" modified="2017-04-12" version="1">MSSKFANRRKPRKVGGDDSEEEDSGIAPEPIVKRPVKSKAKPKSKLNLSFGAEETSMTDDGDRESEVVLPKRHGLGRKAMERSAFQRNLTPSGGLDTLSARVGHDRDRPSYSREYLKELQNSTPSTPKASTDDEKDRSIDVAAKFGEVMVVSGSSAIPSEAEIREKKARRARLALEHGSGKEDDFISLEDNIGSDDDWDAIARGEKLPEKEVDTRLVRDDEDFAEGFDEYVEDGKISLGRKAEREQQRKQRDAMRELIEDAETLSDDEDSDIEEKAAYEAAQTKAAIGSGRAGGIDRPRTPPKMTSLPKLASSLERLRTTLATMETSKTQMISRMEDLRKEKEEIAMREVEIQALIKEAGDNYERLKKEAGIDPAADASEGAMVKRGLESIGAPMAVSDSSSEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRQ5</accession>
    <name>A0A1Q5SRQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRQ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="54792" checksum="5062030B087370EE" modified="2017-04-12" version="1">MDTHDVSDVPEYLEYLRGHKQNLKNAQAVKGCPARSKKSRDEILMQFMVRQMMNKEPPAHPNYIRSSFLPPAYTPCVTPFSKLEKVMMKSLFLETHHRGRYLLLRTVTPIDISTAVMAIVEDEDGSVLMIQLYNQEQELLGAQSLREGTVLAVKEPYVKVMADGDYGIRVDHLSDVRFIPEFDDLVPLSWRKRITQADESAPFWKEKGNENFTRGDYKSAVQWYSKSLETHSSPELLVTVQLNRALAFLKSHCFDAALRDVEDVLKVSELSEKALFRKGQALYQLGRFRESCETFAILTEKYPKNATAAHENVHENVHENAHEYAHEYARASARLVEQESGKYDFRKMIKEAKKRQPPRLNRGTYIGPVTVKQTQYHGRGLFTTQAVKAGDLLFCEKAFAHAFHDENASKGLRLLLNVDMNKATIGTQGELIQLIVQKLYKNPSLLPDFVKHHHGTYKSVDCLEVDSEPVVDRYVSVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRR1</accession>
    <name>A0A1Q5SRR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_13333</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRR1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000345">
        <property type="entry name" value="Mechanosensitive ion channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="834"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="904"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO90616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="940" mass="106105" checksum="250CE00158B8FD7E" modified="2017-04-12" version="1">MSSPSDERKTFHLQEKRDGKRSDSDEVTPTSDDGTFVHDSNAEDRRDRLKVDTTYNEDHPPLMSTPSARREQSTRLEDDLMLLQAERVASRSTQGEHAEGDRNSMSRSRSRRSEAVDEFDEATNPLHEKAAVYKPPESPNTKLSAFVKKVHQSSFIIRYLTYILPVVLLLLIPLLVGALKFTETSVGGVELMWFSIWLEIVWLTLWAGRIVGKCIPPVVSVLASIFTNNAKKWRDMAYQLEIHAALFFWWLGVEISFLPTMKNHHVDGDKGTRSWENTVNKIIIVVFVWTILNLIEKIIIQLIAISFHLRTYADRIEINKFQIGSLVKLYAWSRDRIEESDEAFEEKQNDETPTGVKTPLKYAGIAHRAAKGVLNKAGNKVSDMAGVVAADFTGRKVHASSDPYQVIRTLLRTTSGCQVLARRLYRTFVRDGFDTVFSGDLKEAFDNSEEAEAAFSMFDRDMNGDISMEELESVCVDIGRERKSITASLKDLDSVVSKLDDIFMFFVLVIVIIVFLSLISTSAAGVLTSAGSSILALSWLFSATAQEFLQSVIFVFVKHPFDVGDRVTIYGNAGDAGLGDDYFVKEITLLYTEFKKMQGHVVQAPNSYLNGLFILNQRRSGALAEAIPIIIKYGTTIDQIDGLRQRLLEFVRSEKRDFQSNILTELRAVTENFSLTLNVVFFYKSNWQNEGLRLQRRNKFICMLMIALQEIGIEGPRMNLQGANIDIPFHVNYAQPMMAPTPKKDDDVQEIEEVPIGRGSGSMAENTGTSSAVRQHSILRKGMNTAAARARGQSTSRKHVDFSLGMSNMSSNDIMGDVFEDRSVRVDDIVRTSNREAQERRIQEAVEEEQEERRSHASSRMSSRHRRPSNLSAPSQARPSTDAPSFTSGTSSTRNRFFRHRSSMSRDRDDLMEQGRVDSPPPAAVVQATQEQQQQHDHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS58</accession>
    <name>A0A1Q5SS58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS58"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS58"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="575" mass="64736" checksum="A30889B836B3B9FE" modified="2017-04-12" version="1">MPGRSSALNDTTIGLLRSKSGCKTCKIRRVKCGEEKPHCVRCTSTGRKCEYDGRKPSRFSIVSTQPVLANSLSLSPNTMWRERRAFAYYFQNAASAVGGGLDVDFWRTIVPQVCRSEPAVWDAIISVSALFESPEPISDPDLTQNHRDALGWYSRSVSAVRQQIERGSVDTFVGLISCVLFICIEALQGGVDEAIQLYCQGVHLIMALRTQIASGLVTAAKAALLEDTIVPIFIRLGLIGFTFSRPQIGLLLRGVKRKPRQIFSFVSLRSAREDITRLGTEIQFFQHSCGEYLLNPDDSRIPQDLLDLQADLSVQLRDWHSAFMNLVDSLSLHGTVAMTSEDTGTIALFSAIYESLFIMLEVSASSSEVITDAFLPNFQRIVEQSRIALDASMRSDGTQPPFTFDINPGVALWFTCLRCRDPTIRRESLALMLRSPRVQGFYSCMSAVYFGERIMLLEEMNGEVMRANPETEHFSTTESLIGYQYSPSPSPSLSPRSADYVDTPSTYSIPEEARIGHFDVFQPKRGLPPDITEEVMTKWNLRRDRTFLGFWRNERDEGSDTWRMVREYIPMDMKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS74</accession>
    <name>A0A1Q5SS74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS74"/>
    <dbReference type="OrthoDB" id="4508307at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="99" mass="11789" checksum="8BD61DC260CE46DB" modified="2017-04-12" version="1">MCFFVGYFYDECRHVRFALHLFCDALFAQLQRINDAEQRELFWLPFDPDLPDCEPYCLFNEDGFPFSSDEPGTGNALWWVFNLSEACPECERIREMWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSC9</accession>
    <name>A0A1Q5SSC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_13199</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSC9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSC9"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="135"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="198"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKO90898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="549" mass="58277" checksum="09B5EDBD7C2C019D" modified="2017-04-12" version="1">MPITNKEATPGAAMKAEIEDYTTALEVVKTYSTQDGLDVDTLLDSDKHGALTYNDFLLLPGYIGFPASDVSLDTPVTKRITLKAPLLSSPMDTVTEHNMAIHMALLGGLGVIHHNCAPEDQAEMVRKVKRYENGFILDPVVLSPKATVGEAKDLKAKWGFGGFPVTEDGTLRSKLVGMVTSRDIQFHKDLSEPVTAIMATDLVTAPAGTTLAEANEVLRQSKKGKLPIVDTSGNLVSLLSRSDLMKNLHYPLASKLPDSKQLICAAAIGTREEDKYRLRLLVEAGLDIVILDSSNGSSMYQIDMLKYIKKEFPQIDVIAGNVVTKEQAAMLIAAGADGLRIGMGAGSACITQEVMAVGRPQAAAVRSVSAFAARFGVPCIADGGVQNIGHIVKGLALGASTVMMGGLLAGTTESPGEYFVSNEGQLVKSYRGMGSIAAMEDKKAGGNSKDSKASKASNAGTARYFSENSRVLVAQGVAGSVLDRGSVTKFVPYLVAGVQHSLQDMGVKSLDDLHDGVNKGLVRFEMRSASAQVEGNVHGLHSYDKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSY5</accession>
    <name>A0A1Q5SSY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSY5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="140" mass="16088" checksum="14EE84FE176AE68B" modified="2017-04-12" version="1">MVQWGVTTFCYDDWTNPTFASLIAVLSRLIARKQKVAEEMVKIEKAFHTHAERNKVAQESILGTQRVENELSGRLKMLQALEELGNVDGETYRGFISEQKEVFKMALRQVKATRLRTEELVFQSAHGMSMLEKARNNLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV32</accession>
    <name>A0A1Q5SV32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV32"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SV32"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="139"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO91859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="35518" checksum="CC155ACAF5D65D7C" modified="2017-04-12" version="1">MESVHHVSTSSKILFGKVRRMVPPMLEKFHKGCDMVVKSYSPNLMVHPILPSTDSVKDPKSINAPELAGPIISMLSRLHSLVIGPGLGRDRVTLKVVAEVIKEARSRSIPFVLDADGLLIVTEDPDLVKGYKECILTPNVVEFGRLAKALGIEVKSQADIAKGGGDGDQTSKESDACEQLSRALGGVTILQKGPHDVISNGVTSIISDIKGGLKRSGGQGDTLTGSLGTMLAWRAAYHDKLWDSGEKDNEKEAQSKEDVQAELEIEGRRMSPTTTLLLAAWAGSCITRECSRRAFEAKGRSMQASDLTDEVHPSFLRLIGEPEGSKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW68</accession>
    <name>A0A1Q5SW68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW68"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="206" mass="23530" checksum="D503FA1832822DE3" modified="2017-04-12" version="1">MEKPEAVNFEAVCEEGATLHKIGSDDMWTQTALTAVARDYDQKEKTMLVMQAIRYYKKAIFWSLIISMCVIMEGFDTNLLGNFYPYLHTSSSKSAWIQEAAYSLSVGANDLALFACFASWFLLMPFLWGGCPLVVFGWAYFRLPETKGRTFDELDTLFAKRVPARKVDSTDVDAFNEEENGKLATQYARKRSLESLSEESKWSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXJ3</accession>
    <name>A0A1Q5SXJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase 21.3 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXJ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXJ3"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO92626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="197" mass="21422" checksum="54DD333D1EEEE37B" modified="2017-04-12" version="1">MANHEEDHHYHPQDAVSAAIKTTMMTGGIGLFASAVQNTLVRQNVGPLGIFMRSGSTITILAAMGGTYEFAKTASANLREKKDPWNTAIGGFFSGSILGLRARSLPAVLGYGIALSTGMFAFDYTGGTLFGYSKDKNEDEFDRRTKLRKAFQTPAEQTFAELGEGRGIYGPNYEERRAERIKEAYGIEVPRSPVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SY87</accession>
    <name>A0A1Q5SY87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000736">
        <property type="protein sequence ID" value="OKO92954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SY87"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="12028" checksum="6145C80C39C241F1" modified="2017-04-12" version="1">MDVDISKYAWVAVKDNGQRSFHHPKSSKRSTLMEMRLFEAEENSRLQTNPKEANGIEVEDSEAVALDARPSSIKGEDSIPLEERDANFGEVDDMKFTEEDLDINKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZB4</accession>
    <name>A0A1Q5SZB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1593-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZB4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZB4"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="2">
        <location>
            <begin position="371"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="56185" checksum="78E0ED973EF3BCC0" modified="2017-04-12" version="1">MANRSSLRHCTSKPRVFIVSDISNEPDDAESLVRFLLYGNEFDIQGLVACTSCWMKTNVHPEDMHKIIDAYAEVVGNLNNHVHPENQFPTASYLHSIVKPGPAVYGKQALQPNFHLSEGSQLLVDRVDASDDALWVLCWGGTNVLAQALQYVQKGRSKDEATKFCSKLRIYAISDQDDTSHWIRITFPNIFYICSLHAWKEYPMAAWTGISGDLLAPLDDGAPDKTKITKEWLKKHIQIGPYGSVYPDYSFIMEGDTPTFLYLIQNGLGSPEHPHWGSWGGRYGLVDLGGSSKHYADVKDEVVGVNGMKAFSSQATVWRWRDAYQDDFAARMQWTLSADRLKANHAPVIIVNDSTAGPEHLYIEIEAGSHITLDARESYDPDGDELSFQWFQYKEPTRTQSDVHWHFVPDVEVELADGIEPSGAMVRVQIPPAELCAVNILTGEPLEKGQIFHLILEVKDSGIPSMRTYKRIVMQITNIKGLGALGKAYETVTEAIENKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0G2</accession>
    <name>A0A1Q5T0G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0G2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0G2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="57159" checksum="29EFB4509E36DE94" modified="2017-04-12" version="1">MQAESSPPEHTSVQLDMQLIRGHETELSTGLTESVSPDVRFSLPQSHHLQASTDTPALPMTSDSPRATTSSRNSPEPDETDLEGHYVGASSGVSFLLRVQKRLHENFRISATETIFNFGDAPLPTCDPHFLVLPPIREAKVLVDRYFDFSFPTHRFLHQRTVEAWLQDFYSGVNETSNFVDRAVKAVILMVLAQGKQYLAENDGLVGESVKSGILRELYGIQRKPLDVQVEIARKYGADLIQWRRDIGAFIDTPNIELLQVTYQRQYTVLNFAFAHAQILLYRPFVLRNLASVGKGTVQDSSHLRTLSEENIKKCLQAATRILEIFQILCRTRRMYKSFFFTHYYVFSAIVVLYVSVIQNWMNLDFEPIHNLRIGEEAQRELAKCGTQASFPQRYVVVLEELRQEAKRIMNQTRGRQDPSIVTLKVHEQLSEPSFTPSSEPFNQVGATFTAPLYHSSTGGWANEAVEDTTPDSHFADVTGWGDFDSLVLTGLGELGHFFSDNHLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0K0</accession>
    <name>A0A1Q5T0K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-interacting GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0K0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0K0"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO93720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="367" mass="40277" checksum="0AD7E83E3F03BF58" modified="2017-04-12" version="1">MSTTIDKIKEIETEMARTQKNKNTSFHLGQLKAKLAKLKRELLTPSGGGGGGGAGFDVARTGVASVGFIGFPSVGKSTLMSKLTGQHSEAAAYEFTTLTTVPGQVMYNGAKIQILDLPGIIQGAKDGKGRGRQVIAVAKTCHLIFIVLDVNKPLVDKRVIENELEGFGIRINKSPPNIVFRKKDKGGIAITSTVPLTNISQEEIKAVMNEYKISSADISIRCDATIDDLIDVLEAKSRAYIPVVYALNKIDAISIEELDLLYRIPNAVPISSEHGWNIDELLEMMWEKLNLRRVYTKPKGRAPDYTAPVVLRATGCTVEDFCNAIHRTIKDQFKHAIVYGRSVKHQPQRVGLAHELADEDIVSIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1S2</accession>
    <name>A0A1Q5T1S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000720">
        <property type="protein sequence ID" value="OKO94132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1S2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="123" mass="14452" checksum="13F5DC06159E8CFE" modified="2017-04-12" version="1">MALETTHSRLRRWKNGPPQTLSQLKDEKLRQHNQQERENDFYRKSFQIFHQLADTVMDTIQTLALEYHFNPAAVPAKDPRLIRAVILLQIALDKSHTDESEAIKQWKEQCGIQTNNDSPTEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2H2</accession>
    <name>A0A1Q5T2H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome oxidase c assembly-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2H2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2H2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29199" checksum="3323C3379196B111" modified="2017-04-12" version="1">MSRSAADATRFTATGPYASSKPNGAPYELPSFMQSKDNAKQAKPTAPQTGPDGQPETPKQKVERLRAQARAARMAQQSSGVDRWIESGRRFANRAHKGMVYSLIVASGVCGVLTVYSMVSLTLYNRRQRTLWIEKEMENLKQARLAKASGAATTEQLELIEKEDIAEIVKRKRAEEKAQRPWAKAKRFLFDKMNAEDAGASAAAASTAAVATETAQPSVVEAVQAQQAFDAAKAKTGAPVPGQLDVLAENAEQAAKKTTRSWTSWLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2N1</accession>
    <name>A0A1Q5T2N1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11768</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2N1"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="591" mass="64173" checksum="75AD28907CF18BA3" modified="2017-04-12" version="1">MHVENGPETSDDLALARLGKKQVLKRRFNFMAIVGFAMAELITWETVLTLFSQSFDNGGPAGAFYGYIIACLSTLSTYTVIAELASMAPIAGGQYYWVYMLAPMRWKKVCSYLIGWLTSLAWIATIATETIFLGTMIEGLITLNNPDFAQQRWQNTLLAWASVAGTFFINVVVPHILPRFEIFMLVLHLAGFIAITAVLLAMSPKKSADFVFHTTLNEGNWPTQGISYCVGFIGNIATFVGADASVHMAEEVANAAVVIPQAIIAGMSINSALGFSMMLTVLFCLGDVESVLNTATGFPFIQIFYDVTHSYAGASVMTALIMVLTMACSTGITATASRMTWSFARDQGLPFSHYLKKVNHRTKVPIVSVTVVCGLACALTLIYIGSTTAFNDVISLTVTGFYGTYFLPSAFLLYHRIKGNVLPHGTMMDGLSDSAVAATSATANSAEKPATPVRPKSLIDKETPTSGPSQSPERNIPEKKGIQPTEYAIAQAPLIWGPWKVPGILGTINNAYACVYMLFVIFWSVWPPETPVDYTTMNYSIVVTGGVLILSGIWYFVRARKEYSGPLIDEEVAEIMHLAPAAIAATVPKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2P7</accession>
    <name>A0A1Q5T2P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 14">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_11780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2P7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2P7"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001909">
        <property type="entry name" value="DNA mismatch repair protein msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="17">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO94513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124608" checksum="D5DF34A1AA5C1C48" modified="2017-04-12" version="1">MAPHSSQSSAPSPSLKRKQATISSFFTQKPSSTPKPASSSAETVPEKTSKKRAASPIEPSPERKRAVSIHEQDEDQDDIVVPPSKRARTNGSIAGESKPAPPPAELPLNPASQLSSSSSQRTDIFKFQSSPAIAPPSKEAEDPEETQRRKEKEKQHQKFVRKLGGPDCLIGIGRAAAGDQSGAAAEAEEEEEEDEPAPPPPTKGKGAKKGGSKLTPMEKQVIEIKRKHMDTVLVIEVGYKFRFFGEDARIAAKELGIVCIPGKFRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVTAGHKVGVVRQIETAALKAAGDNRNAPFVRKLTNLYTKGTYIDDVEGLEGPAAAAGGASPATGYMLCITETNAKGWGNDERVHVGIVAVQPATGDVIYDDFEDGFMRSEIETRLLHIAPCEILIVGEMSKASEKLVQHLSGSKMNVFGDAVRLERSPKKKTAAAEAHSHVSGFYAGKMKATGTEDDVQAAKLLQNVLELPEQVTVCLSAMIEHMTEYGLEHVFDLTKYFQPFSARSHMLLNGNTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRRWVGRPLLDKVRLEERTNAIEELTNPVRTVIVERVRRLLGKIKSDLEKSLIRIYYGKCTRPELLTVLQTMQTIAMEFADVKSPADTGFESTLISEAIASLPTILKDITRFLDKINLHAARNDDKYSFFREEEETEEIGEEKLGIGSIEHELQEHLSVASERLQRKGVKYVTVSGIEYLIEIENNSLAIKKVPASWIKVSGTKKVSRFHTPEVIQLIRQRDQHKEALAAACDKAFAALLGDIATQYQSFRDCVQSLATLDCLLSLAVIAQQPGYVKPEFTERPCLHVEQGRHPMVERILTDTYVPNDTNLDPDGTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPAASAKLGLLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRNIRSLTLFITHYQHLSRMVRSFPNRELRNVHMRFTESGEKDGDEEITFLYEVAEGVAHRSYGLNVARLAHLPASVLELAKTKSAELEELIKRKRLAALVGAVGRVVEVRDGGGAVSAEDELVERLLASADQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Q5</accession>
    <name>A0A1Q5T2Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein LUTEIN DEFICIENT 5, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Q5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Q5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="554" mass="62129" checksum="F326326C663CEFDF" modified="2017-04-12" version="1">MSTARERLVLLIPPTVVGTGLIIYSRMTSERPATIFLYTLAINFVLMAIWNIFIWPFFVNPLRHLPTVHGPLIGAKVFLRQPRGSIIVDWLRTIPNEGLIHFREALNYSFVVATNHRALMDVLHTNSYDFVKPPGGREFLARGLGYGLILSEGDAHRAARKAVTPAFNIKNIRAMYPLMWMKTQHLLRQLQKEIDLHPVPGRKEGQSAGVVEIQGWANRLTLDIIGPAAIGRDFQSLENENDPVSQNFNAILKPSLDLLMLFAVSIILPQWFVKRIPCNANSVLPEKVEYLRKLFADILHEKRAQIAQEKTQQEAAEGDILGTMMRGGEFSDSELVDQMLTFLAAGHETTAGALTWCCYHLCIEPDIQEKLRSEIYATIPSPSASLSWQDLEGMPYLNGVCQEVLRLYPTVPMTGREAIRETTIAGKKIPKGTTIALCPQAINRNPEFWGETADQFLPERWIDTDEKTGKQTPNKHGGASTNFAQITFLHGPRACIGKDFAKAEFRCAVAGLFGMFRFQLKEPGQKITFGGTLTTQPIEGMHLKLTKLEGWNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2X8</accession>
    <name>A0A1Q5T2X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2X8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2X8"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF20">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="31"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO94589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="412" mass="45583" checksum="10631A93D29D8762" modified="2017-04-12" version="1">MAFTNLGDLPVLPQPESFALTAAYNEDTFPNKVNLGQGVYRDNNCQPWVLPSIREAEQTLHNQQVNHEYLPIAGHAQFLTKARDLLFSPAIASQDNITSIQAVAGTGANHLAAIFCARNLRPKNVFISDPTWDNHHLIWEIAAPNVTRKLYPYYDPCTRGLNFDGMLSELEKSAEENDVVILHACAHNPTGIDPTQDQWKKIADAVRRKKLIVIFDCAYQGFASGAADADAWAIRYFYTTLFTESSSSTGPAGMFVCQSLSKNFGLYGERIGALHLITPPLLPTQGAKAHLVRLVRAEISCPSLFGARLVHTVLDDTELVSKWHEDVKTMAHRIKGVRALLKSELETLGAQGDWGHIEQQIGMFSFTGLSSAQVQQLREKHHIYMLSNGRMSLSGLDEGNVAYVAQAIKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4M9</accession>
    <name>A0A1Q5T4M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4M9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="30930" checksum="E09557CA6CE3D14D" modified="2017-04-12" version="1">MHSAPSSTFWVPEGTEITTEAKPNQQLPTRTWIITKKLKELSFFMTQQDINDGHKPGFAAAKFLCHPKDDPNKLAFMRIYRQIPISGFESAPSSIRASQAVPQKPNRELAAFKELKHLACPVVPQLLGYQEGTQGDNEIVPGGYEISIVWEKVPGEPLSQDYFWSLNEQQRDSIREEFRRVYRQVLRSGFKPCMATTSKLIYDESTGKMHICGFRMAAPCDTNQQIRKADYVMYGLAKRSDRTDWYNDASGWKCCYRGPPVFLEAADASGGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q6</accession>
    <name>A0A1Q5T4Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18255" checksum="95BDCAFA390600AA" modified="2017-04-12" version="1">MGHIFEAQSIDLRFADFKCLGSPYTGVPDVILKNSNNELKVIGELKVPWIEQHKLADVDDEDELRQLLAQPINYMQSLNCMYGFLSTYDETIFLRQELINGVWEVSYSPVIQGSTRYVPSKPTNVVSSPVVSVKQCFLYVAGLAVHQGPVANITPKSEWFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N7</accession>
    <name>A0A1Q5T5N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012637726" description="Autophagy-related protein 27" evidence="3">
        <location>
            <begin position="31"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="40037" checksum="D77017609479ECC4" modified="2017-04-12" version="1">MSAPRPLSRVPSQMALLFLAGTLLPMGSTAGRTSATGGEGYRLGEEIPITDDLGKLQWIPFVTCNETSRPLSLHYGTSETITCTIPSLSDSLYHLLEFYVHSDAPMTCRVPTAPLTSSNTAPKDRTDPDPASGEVDSLAVLSENGPPFTPITIALQGTLQLSHLHIWTDMNMLMHNIASDAAAQPAKARKHGQSGQPGYAVAGTAYSTPEFEAAAKKVSLDEDEEAVTVAQAAREPWTAGHGTKVVRGEPLTFSFHVAWIEGGAGIGWPERPASESFLEMSGARAAQGSGAGSFFSRLFLFFLAASVGALVALYWERNGRGRSGWRGDGILGAPPAKGKGPGVTFGNGGRINGYGGYSAATTNGVGTGGGGGTGYGGFTTGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5W1</accession>
    <name>A0A1Q5T5W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5W1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5W1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="9310" checksum="31183A7126338ACC" modified="2017-04-12" version="1">MGSEASFHEFPAHIHDLVTSLLSESHVVYTRIYPRYKSHGELQTAVTQFSAWYVLALSKETLERYALTTPFAGYRLMKPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T817</accession>
    <name>A0A1Q5T817_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">PENSUB_10547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T817"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T817"/>
    <dbReference type="OrthoDB" id="5418434at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22890">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO96372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="19049" checksum="7788EE2B4A0FADC2" modified="2017-04-12" version="1">MSEEVPPAQTFTAADRIRQLNEIDHDVAKLLQSAGLAIQALTNTKPDSDTPFDGSLESHKALFKEATAKYFSLLSSIDVRLRRQVYALEEASLTTPDMATKGDTTGAGAGAVGAAGAGAGATNPLDISWLNSRKDTVGKDKEAELWAAARGFVEQLDKAPDGLNGSIKQEAGESEKMQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T879</accession>
    <name>A0A1Q5T879_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_10573</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T879"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T879"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="16">
        <location>
            <begin position="331"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO96398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="534" mass="58507" checksum="88F2024A3BF509CA" modified="2017-04-12" version="1">MAPHASSDVANGTVNGSARQEASPLFTVQSPNVVYTDNEIKSQYAYQTTEITRTADNKLVATPKATNYHFKVERKVGKVGMMLVGWGGNNGSTVTAGIIANRRGLSWETREGQQQSNYYGSIVMSSTVKLGTDAKTGEEINIPFRDLLPMVHPNDLVIGGWDISSLDLAASMDRAQVLEPSLKAMVRKEMAEMKPLPSIYYPDFIAANQEDRADNVLEGTKASWAHVEQIQKDIRDFKAQNGLDKVIVMWTANTERYADILPGVNDTADNLINSIKNGHEEVAPSTVFAIASILENAPFINGSPQNTFVPGALQFAEQRGAFIGGDDFKSGQTKMKSALVDFLINAGIKLTSIASYNHLGNNDGKNLSSQKQFRSKEISKSNVVDDMVAANHILYEKDEHPDHTVVIKYMPAVGDNKRALDEYYAEIFMGGHQTISLFNICEDSLLASPLIIDLVVLAEMMTRVSWKADSEGAEYKGFHSVLSVLSYMLKAPLTPPGTPVVNALGKQRSALINIFRACVGLQPESEMTLEHKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8F2</accession>
    <name>A0A1Q5T8F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8F2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8F2"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180244" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="19179" checksum="EBFCA2E7FFD4322D" modified="2017-04-12" version="1">MKFLSAAALLLASPLVAAASFPALFDPSQAPIRAEDERKNPVDGENPLEFCEPPSSHLLTIDSVDLSPNPPQAGETLTITASGTFHETITKGAIVNVEVKWGVITLVKQTMDLCDQIENVDLKCPLEKGSMVLTKQVDLPKQIPPGRYSVLADVYTKDEKKVTCLKADNIEFKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8L0</accession>
    <name>A0A1Q5T8L0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lysophospholipase</fullName>
            <ecNumber evidence="3 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_10744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8L0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8L0"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000024">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="140"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="637"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO96569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="797" mass="88962" checksum="99B7940D26DCA859" modified="2017-04-12" version="1">MGASRIGRLRWTVPPAALAAYTAGEWNRRLPQSSYFTTTSSWYETKAESRNDASHKKGSSEHHDPDSVWFKVAQKLDNVKHTVGAGAWGDLGGNITEYIMPDWARLLPATAQKLQRELSMAPGSLADEIWKESHDPDINPEILRDAEVRVSGELCNEELAFREKRRHHARKALASYLDIPEEEIHPDDVPVIAMCGSGGGLRALVAGTGSYLAAQEAGLWDCITYTAGVSGSCWLQTLYHSSLADGNFNRLVDHLKNRLGVHIAFPPAALNLLTTAPTNKFLLSGLVEKLKADPSADFGLVDIYGMLLAARLLVPRGELGVNDRDLKISNQQVNLLNGEHPMPIYTAVRHEIPVLAEEARDDEHQTPEDLMKKAKQESWFQWFEFTPYEFFCEELNAGIPTWALGRHFHEGRNETPSHTYPIPELRVPGLMGIWGSAFCATLSHYYKEVRPLVKGLAGFGGIDSLIRGKNEDLIRVHPIDPAAIPNYVMGMKDQLPASCPESIFQDKHLRLMDAGMSNNLPIYPLIRPGRDVDVIVAFDASADIQQENWLSVVDGYARQRGIKGWPVGAGWPRATETLAETEKALREPENITDEQANQKIAESQNHQENASNNKKNNSTSTADTDLGYCNVWVGTQEERISKDEPPPSKRLFHPDNNEDHSESDFHLMRPEAGIAVVYFPLIPNPSAPKLPPTQKTRPLAAVQSLQQSQNQVKDPADPVAPQPNSIDPDVDDFLSTWNFIYTPEQIDSVVGLARANFSQGKDQVRRVVRAVYERKKSDRLRREEVEARKRMEGFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9N3</accession>
    <name>A0A1Q5T9N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gephyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9N3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9N3"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="319"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="601" mass="62825" checksum="32347572DC941A69" modified="2017-04-12" version="1">MARPVAGVRDKTLIITLPGSPKGAMENLDAVVKLLPHACLQSAGGSSRTMHAGGLKKLEAEAGVSSPSEQRQPQQQQHSHDHHHHHHHGHGHGHGHVGPKAHTSPADRPQSNDPSAGPNQRYRSSPYPMLSVEEALRQISEHTPEPIVIEAPVNPSVVGSVIAEDVFATEAVPAYKASIVDGYAVIASDSPTGPSTKGVFPVASVTHANVGGGLQPLQPGTIARITTGAPLPPNANAVVMVEDTVLASSTPDGTEEATVEILTGDIRPGENVREPGSDVSLGSKILARGDVISPVGGEIGLLAATGNRTVKVFKKPRVGVLSTGDELVEHDDPRTLTGGQIRDSNRPSLLSCLQSWGFPTVDLGIARDTPAGEIEHALRDSLRGVGRASSSVDVIVTTGGVSMGELDLLKPTIERSLGGTIHFGRVSMKPGKPTTFATIPFKEAATSATEGTQQERQSKLIFSLPGNPASALVTLNLFVLPSLHKLSGLGKSSQALASKPWMAPQLGLPRVAVVLTHHFPLDPKRTEYHRAIVTASRSDGRLYATSTGLGGTGQRSSRVGSLASANALVVLRPGRGVGIKGEIMEALMMGPVHACDTRLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAU7</accession>
    <name>A0A1Q5TAU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAU7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAU7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="43543" checksum="EADBE36BFD57DA89" modified="2017-04-12" version="1">MATEDDNFDIDIYGDGGGFSANDQGDAKQEGDDLDLDIPEPEGQATTNDTNDTSTLEPSSTSKAQTEPLHSSNSTHHSLPSQASHIPHSTNGDHTMSQEQLSTQDAMSAPHGIKRKDYEDRPTDPDATTALVISDLYWWTTDDDIRGWVNSAHAEDELKEVTFNEHKVNGKSKGQAFVEFTTTQAATATKHYLETASGLKHTAQYASAQMNPFKTHPKDALMRKDGSRGNASFNSGGNQNMNFGGGGNMNMGGYRGRGGYNNNRGPGNMGGFNNRNNFNNMGGFQGGNAPAAGGMMGGFQAGPMGMQNFGFNNRGGMMNNMRGGPGGMRGGRGGNMAGAGMMMPGMNPMGGMGMNPMAGGGMNPMMGNMGGNMGMQGFQGPNPAFNQNFFGGANQGGDGTWNPHGAKRSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCK2</accession>
    <name>A0A1Q5TCK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCK2"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56050" checksum="862D6297731C17B8" modified="2017-04-12" version="1">MPAGVQSDEYELSSESLLGWRKNDLPGYEWRHHTSTLRWMGRKLSALSTAVILLLVHTLSVLFGLGVRRRAIFLIRLTLGGLLVLICLTGLFWPSYTHLPPHYKTLRNQVHSSGSPGRGNIENQKVYIAAVLYDPEGTIANGRWGDAILQLIELLGEQNVFLSIYENNSAQEGENALQALADRVTCNKSIVSEPGLSLGKIPRVAIPGGNMRIRRIDYLAEVRNRALKPLQSAGMTYDKIIYLNDVIFDPVEALQLLFCTNADSDGVAQYRAACAVDFSNAFKFYDTYATRDLEGYGIGLPFYPWFTTAGKAQSRQDVLEGRDAVRVRSCWGGMVAFDAKFFQDPDPVRFRADSEIFWDASECCIIHADLRDAIPTLEGSHSSGSYMNPFVRVAYDARSHSWLWTTRRFEKLYPFIHNILSHLVGFPRYNPRRTELSGQKIMDTIWVPGDGKGKEGKVRTTEREAGNDGFCGRRGLEVLVEKRMSGQDGFEPIKVPAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD33</accession>
    <name>A0A1Q5TD33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000674">
        <property type="protein sequence ID" value="OKO98127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD33"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="205" mass="21766" checksum="E7F72EB27AF306DE" modified="2017-04-12" version="1">MARRDNQPVGPLQATLQEITTAATARALEGQKIFSPIATFLDNHRRQNTGLTPGQLEALAALSNDLANVAQQHFNAYISGVPLTNSPTTPAPALAPAPLPPSPPPSRPPSGLAQSTYASVTQSPPAKNAAARQTNGTTKTDKLAAKLPSPDNRLFVRLPENHLAKSMDAFAIYTSLRSHLDTNGKLLKGVQSIKTGFALLPRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDF0</accession>
    <name>A0A1Q5TDF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDF0"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="41250" checksum="E2E909DACA99B059" modified="2017-04-12" version="1">MSTSSTSAAQTGHPELVYRSLPILASYLVLAGSLALNASRTIFIRYQARLKKNDWENPQRRVQFLLFAILAALSLGATWYYMFAFFAHSYRNWEASQSLVDLADPEITTLFKLELWLQKAKLFREAWETVIETPARFWWSGQIFLWTTGWSVFLGIMARRYRIPHVWAYMLLGQIVAISLAQNLFFATILVSRQPHPTEGTKKNKSNAQDSISAWSPPLYSEVLPVAISLISTVLVPTVAHTKHFMLMLLVPHLLLFVPAILRPGQSSRAKNSSEERTVRKYITFFQWYTMACVAIQAHSTFLVLQDMGLDISIESLRVLATNLPSVIYEHPAVSSVSWDVIYCTVTAGAWIAVNGGSPKRMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDF4</accession>
    <name>A0A1Q5TDF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="257" mass="28655" checksum="108274BC22E5A942" modified="2017-04-12" version="1">MFVVLSAPADGDPHPRTSPITVRRVHWEVLAGPGHWILNGPHVDDIPDGPEENSGSSESNILPENYFGAKSLKKVLDTHTPKDISDAKQECTRVWANPHGRDVLKYYFNNCCPFCHSEGCVCAGCGGMSQKYPDIYGSCGTDQACPMCHGLDHAIRDKAFLEPLDEAKMELWAHNDAKSRIMESSEANATQDGPLYDYKNEYFLTQWWTTCNGRNLSLRKTSLVQQREKKRNGPQGTGSRPGYPRVKGVLPNYGSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDR1</accession>
    <name>A0A1Q5TDR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosome biogenesis protein enp2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDR1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDR1"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="413"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="547"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="718" mass="80896" checksum="3B32343D223A0AAF" modified="2017-04-12" version="1">MKLSNQSEVPVYTISGSNTARPLPEWLARRRKRSLKDDPEYANRIELLQDFEFEEASQCVKVSEDGEWVMSTGTYKPQIHVHQLSQLSLSWARHTVALNTKFLLLSSDYSKSLHLQGDRSLEFHTPQGCHYTTRLPRYGRDLVYDRQSTEALIPSVGVNENGLGEVFRLNMELGRYMRSFEIEVGGDDFTSAGGGALQGGINTGSVNTGAIAEESHNLLAFGTSIGTVELWDPRAKGRAGILLPPAQSVGDVTRSEITALEFHRNGLTLGTGSSNGLIHLYDLRSPVPLLKKDQGYGFPIHTLKFLQASTETREATMDPKIMSADKRIIKIWDPRDGTPWTSVEPAVDINDVAWCKDSGMLLTANEGRQQHSFFIPQLGPAPKWCSFLDNLVEEMAEDPNDPNAFTSAQAGSIYDNYKFLTVPQLRTLNLEHLIGRTNLLRPYMHGYFVAQRLYEEARLITNPYIWEEERAKRVKEKIDKERESRIRGKKKAAVKVNKKLAERLLNAEEKQERRRAKQVLERGGDADMVDAPAVEIEKTEKKGVLGDNRFNKLFEDEDFAVDENSFEFKLINPSTIPDAPPKKERGLTAVEQEAIDDVPGSSDDDSASDSEAEKPVREKASTKISSADYKRTKRPPPRMQISSSTRTNSTRDRSFGSRAQNMKTKQRPTRTNGVVGEREVSFMPASKSRKQKPEVQYDKTEFRAKERRSASGNTFRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE26</accession>
    <name>A0A1Q5TE26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE26"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29738" checksum="23CFC18EDA7EDAE4" modified="2017-04-12" version="1">MAHSEKVSQIPRGRGGALHGDRSDKGSSPLGTAIFAVLRILDPVLQYGILSPGPTSLAAPILGLFGGTPLPLESAPMALGLSPWRLTLLGMSLLGSLKGIFYLFYVSETKMPVKTALLVGIFKAFSTTVNSLMFCAAATSATSSYKPDAVTGWHPILSIACAVFTVGITVETVSELQRRSFKKDPSGRGVGKVYTGGLFRVARHINYGGYTIWKAAAGLAASGWGWGGLTLLWLLAEFRRRGIPALDAYCEKRYGEEWDQFKRRTRWKMIPFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TES5</accession>
    <name>A0A1Q5TES5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TES5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="10936" checksum="AF8506B512DCFEC7" modified="2017-04-12" version="1">MVDAPGQTSEMSAGVATREPRTALSGGRRGRGVEGEERGSFGRLIQEGLNNGDSNSVASIVRVGMGEPRDGSCQGAGDWLGIHGSQVRSLRSTPRVIQVDRLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFG4</accession>
    <name>A0A1Q5TFG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="68" mass="8041" checksum="8BA6C44EFE104512" modified="2017-04-12" version="1">MEVAKHQRLEPDLMPRPNTRSFQDFKPKEIKDSGLFLVAAIERAGAELKWWEEELERLRRTKAAYNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THD1</accession>
    <name>A0A1Q5THD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8289</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THD1"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="47"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="372" mass="40742" checksum="333A1959C1C6F3EA" modified="2017-04-12" version="1">MSMASPTPLPSGVSPPLTTDNEDNHGALIVIMTSFTLVLVLSSLAARIYSAAQRHIFQRDDLLFGILVIVAFVQIAVVLSQVHQGWGVRTDFLTVTDEPMLKTAYAAEILSVLVLGFSKITSSLFYETLFSQMNLRLIRSILGVMIIWTILSVILLAVRCSDKPWYDISAAQCSTLFPRWIAITVFDIVTEILLFLYAGLAIHKIQISLQKKLMVGVTLESRVLLIPLAAIRLYYVNKQIISDDPILLGAYSTITTEIYIAICVVCLISAFLKSFIAVFEDKNGLSYTDGTSGSRPKSKQFASGNTASASNKMGPHSSASADRLKGWEREEDPILDQADGRGLHILKTVHLDVTDESIELAEQGNARTSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI47</accession>
    <name>A0A1Q5TI47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase ksp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8112</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI47"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO99895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="651" mass="73180" checksum="200D443325453191" modified="2017-04-12" version="1">MSTSASMECLKDNFVKGRLLDGRFRTVAPLNHGSFGMVFLATDTTTGNDVAIKCLTKSASTDSSPDDRFEELECHQRFGFHSNLVNLVHNFETEHHTYLVLEYCANGDLYEAIRLNRGPLETEHVRDFMLQLISAVEFMHANGIYHRDIKPENIFLTHDGDMKLGDFGLATREPWCHEACVGSDRYMAPEQYDPGATGYSPAQADIWSVGVCLLNILFARNPFVTPTESDVLFADYVRDRQSLFDIFPNMSQDTFEILTHCMSIDPTKRSLAEVRQCILRAISFTTDDESLDEFCTEDRDVVTATVNREPLRTPSIQSPQVNQGDSFPWAKALQSSPPQAIRQLSAIPDNESYTEDLFPPSEVAGTSWFSVHADSSSLASVLDSAMGESFRSLHLGRKYQTPQLPRSDPVPITGSLPSHTSKLLPSLSMVFGKHANDQISKSWSDLWEEEESENEESALQMRREQNSRSWSQESQNTRLPDPLAGLREPDSASPTEQIDISDISPAAPRAIRAKSLDVASDAGTSSSTPRPFPQPSSTPKKVSPNVDKWAELGDKRRNFKTRELFGPQRVANNWRRDWGLGSSGFDHGSRTKRESPQSERRRRLFLEKDWRRETGDAHKHSLHHSPLKFAAYDGSIDEDLDLVGGWHDLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI57</accession>
    <name>A0A1Q5TI57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI57"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI57"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="16157" checksum="419919E7A49CC0CD" modified="2017-04-12" version="1">MSTVLRTLRNLRRIGLKDFGHQMQNIGDTKAGTLIGVDRFGNKYYENMEEELPLRTRWVDYKVNWPEFQPDQIEPGWHAWISYMVDTPPTVDKLLQPGQRTWEIPEHRPNPTFSRAAFKTYSTTRPKLSAWTPVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI73</accession>
    <name>A0A1Q5TI73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="417" mass="46598" checksum="0B6403AB0325B6B9" modified="2017-04-12" version="1">MTGSIYKSLERPLYLPRSESLIAAVTIGRGSLPSVSFYPIDPSSPDPQCFPGLPHDTYIGGPSSSAASVVDSKKLRKSYQVDSISINAGVCLFSLPMLGPISLHHRTAQNTPLIVPYLPINEGPTLYELEGVSRLAFAIADMVCLIWDRPNPTDVEIEIDVPDFQYYWSIYDFYRSGLIDTSLVCEWMELVDERHNQMGAIMIAAIKSLLRSQFLSLDIEKLRINITSGAETASSLIKKCLTYGIFPSVQGIISSLHSCPMYGVLWQDFFTNLDPDEPMATVTDICRLTYVFKAVRPALRRRRFDKTHMILQVDDIGEHRIFDRAEAILKAYNGDGSLSLVEKRSVMIGLFPLHRISMAHLAHGKALYVHAPLDRLFFDRATGESITIMKMISLTYGVRIAKTVQKAFSQNCLHPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIS6</accession>
    <name>A0A1Q5TIS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000650">
        <property type="protein sequence ID" value="OKP00134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIS6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="652" mass="74605" checksum="48370DFD74A23488" modified="2017-04-12" version="1">MSTASSQSRGVNRRINSLQNDGRHSRNSSLSRRRPLTPAIASSHALRVAYLTYLLHPRTRRIQTAPAAPARPKRSSTSIHDLMSDFSLVRDSKSTRIPHGFVSELEKRLTGVLMGREKKKEYQDHLVVRTFAVFLNVLKEDSFRKRMEKDRRAEDLLLIFYSNAVKELSKGKEQEDDSWKLMVDRHVALFVRLLALILKSNDWAKDRPELANRLTVLENKLLLQDQDLMDSNGPTSTTEVLAPLSYDVKDMPLVQHVAKIFGMTTLQAQSEIDKHKSVWTEKAALRDLKTYQTQLSLHTRKTLCREDFETDEAFESWKKSEGPDLSQMMLAIVQSNPELAKSTPGALPQFNASVSDDLSSPRDRTSYAIDQSVDFSSLSLGGADGDSEESDTYTFIPSDPRGVYRFILNQTLTHDLRDREIEASQATSDTPSMKLLSKQSTEMLNEICLRWRIPNFSRIVLFLDVIQSKYVDSEIDLNTLDSAFTFVKESPSSEPRAKRSSYVASSVFDRRKWSVHDLQTMQQLLSKIHEALLRELYDVMMDCFEAKPRPIGPVMYILEHHIQMDPNYTEDPADIDRFSSYVQDGLAQKATEKYQSLIGQLIPVDQESWRFDNVIQLGDAISKLAQKIQKRYRNNPEIMGYVIRILLLEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJI3</accession>
    <name>A0A1Q5TJI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="36517" checksum="3F7997AF168AE351" modified="2017-04-12" version="1">MPAIVGKEFGPIGFGLMGLTWRATPPSQEQAFEAMRAAVENGCTCWNGGEFYGPPDYNTLVLLEQYLEKYPEDADKIFLNIKGGVNPQTHQTDASPENTRRSIDDCIAQLKGRKKIDIFEFGRRDPAVPLDMTFGLIEKEYIQTGKIGGIALSEVRAETIHEAVKHTAVVAVEAELSLFSTDILENGVAAACAQYGIPIIAYSPIGRGMLTGQFKKWDDLPQDSLLLSFNFPRFQKENFDKNVQLVEKVEQMANTKGCTPAQLAINWTRALSRRPGMPTIVPIPGATTAGRVEENSKLIEISDEEMAEIDDILAQFPPAGGRYPEIFQTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKK8</accession>
    <name>A0A1Q5TKK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Seipin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKK8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKK8"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="358" mass="40499" checksum="07C26A9BAB89B76C" modified="2017-04-12" version="1">MAESEYSDDETEYGSPSHSQAVIMDALLTPFRALVSKTALRIYLNIILFSGATLLLLGISGIAYAIFYFRFIPTVGVGREIHLQFGDLNPWGIATFDSEFVSSQPYDVAVALDLPRTPTNLDVGNFMIDLTLYSPETASVLPTTANSQNKISHSRRPAILTYTSPLVDFARKLVRLPLYVVGWRREAETLEVSMMEKVEFARGSRNRPQSLRLEIQSEKKMQVYSARVEFRARFTGLRWFMYRWKLTFFMVFSSLFWTVSMASASLTWFILTWIMQAEKPEAAIKEEEDIPEAIKEEPEDSSSSSDSVKIKKEEPETKSSFLQSYPAEGDYPGLGSGRESAEARGVQKRKSHTTEGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUE9</accession>
    <name>A0A1Q5TUE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUE9"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP03820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68572" checksum="99A096749335D912" modified="2017-04-12" version="1">MTGLVSDEVAEDYKSSLEDLTGNDRFQISNLTVIAKENTEHAMAISRVLENHIRSTPPQQKLPALYVVDSIVKNVGTPYTLFLGRNMYQTFMNAYTLVDAQTRRKLDEMLKTWKEPVPGSLDTRPVFPPEITRSIESALIKARTAALQQEQARGSRDILNRGRNTGTPPGMSRQVNNHHGTNGQGYGTPTPPQGHRPTSELDALNRDLEACILSARNDFAAAPFDPTSQQRLKALLDLQTIMRNQQLTPDQLRLVRDQLSVFRPQAPALQNPSPSAPPPAAAPVPPPAPVPTPPSQPPSQSLQNLLNSRTLAELIKNTAIRQQPTPPPAIPNAMPQMPQMPQMPQMPAASNTPQPENPLIAALRSRGILPPASAPPVMGSTGQPPTGDPLPFLVPGGMRSTPPAPTPPVSMPVSSTVPMTTASMKIPRVALVVSLYEAKSNRCGTCGRRFPNTQEGKEKKARHLDWHFKTNQRMSEAAKRAQTRSWYVDERDWIKSREVDDDQPIADTDSTTEGGPGAEGNASKQGPPKAWIRAPNDATLRNTPCPICQEKFESTWSEDVQDWIWEDAIKVGSRVYHASCYAEVTKDGPAPRSSTPQARTGTPDSVLGKRKAEGTDSPGGKTRIKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U096</accession>
    <name>A0A1Q5U096_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exo-beta-D-glucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U096"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U096"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012231460" evidence="6">
        <location>
            <begin position="20"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="10">
        <location>
            <begin position="63"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="7">
        <location>
            <begin position="224"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="8">
        <location>
            <begin position="684"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="9">
        <location>
            <begin position="778"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP05895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="895" mass="100358" checksum="846B64FF08D79B54" modified="2017-04-12" version="1">MNLSQALSALFVGLAGVHAASNNPPPLVSSPGDITVIPGWSLQSSIHAPNDMPRLSQPGVDVSTWHRVGPRGTVMAGLLQAGVFDDTELFYSDNLNQLASETIFRSPWLYREEFTLNPSDNQYFTLHTHGITSKAEIYVNGERIATSDEQQGSYGGHKYNLTDHVHDGTNCLLIRAYPTNYLRDFALGFVDWNPYPSDNGTGVWRNVEISQTGPASMSPFRVITDFTKPGQNQKVNVTLKTDLVNHSQNTVQVSVNGTIIPPTGSKAGPILRSVELKPGESRTVSVEVSVENASIWWPARWGAQPLYTVQANLLLHNKTMTISDKTQAQQFGIRQVSSYVNQHNDTAFVVNGQQFQVMGAGYGPDMFMRFDEGRVEKIFQYMLDMGLNTVRLEGKQEHPELYELADRMGMMVLAGWECCDKWEGWEYNNDAQGVKWGKSDYPIAQAAMLHEAEMMQAHPSMLGFLVGSDYWPNDRATEVYLDAMKAMDWKNPIIASASKRGYPKALGPSGMKMDGPYDWVPPNYWYGDQEGAAFGFGSELGAGVGTPEMGSLKKFMSDSDLDTMWKKPNSSLFHMSRYDSQFFDRSIYNEALFGRYGKATDLEDYVLKCQMADYEATRAQYEAYSAKQNASRPATGSIYWMLNSAWPNLHWQLFDYYLSPIGAYFGTKVGNRLEHVAYDYESENVWLINHSLDLQGDREVSIDLIDANGKTISGTKVKTTTVPNSSKELQKVTGIDKIQDIAFLRLVLRDTKAKRDISRNVYWLSPKNDVLNWDESTWYTTPVTDYADYKKLESLPSATVKATVQTVNAQTKDGWTYADVQLENKSKVPAVFLRLNAINSSNSAEVTPVFWSDNYVTLWPNEKLRLSVGFEGDIKQTVIEVSGRNVKKQSLKSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1M7</accession>
    <name>A0A1Q5U1M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U4/U6.U5 small nuclear ribonucleoprotein component snu23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1M7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1M7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="214" mass="24508" checksum="AFA2D6812DD93A06" modified="2017-04-12" version="1">MSKTNATGPPSSDTAFRKTWDREEYTKKAADEEAKRKAEGKARYEAKLLGKKYHAPVDYGSLSATTARQERLKVDSMVGKTTIVPAGSALGKRGRGAGFYCDDCDLTFKDNIQLVEHFNSKQHLIATGQSGEVARASVEDVRMRLRMLAHRKRVREEEERRAWQLDLGERLREREEIEAKEREERRRKRNEKRRKGGDGVKQEDSWEGRLGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1M8</accession>
    <name>A0A1Q5U1M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1M8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1M8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180240" description="Beta-lactamase-related domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20863" checksum="A4A11624E22ABC7B" modified="2017-04-12" version="1">MASLLARSVSFFLLFSSALSTGFTPCPLLGPGFPPFALDTNDTIVGKALEILTANFDQLVQTGTGPNGDISPNTTFSIALFSANKGTAEDKPFFWEYHHTSPAFKKANHLSQNVTKDSIYRIGGLTEVFTLWSLLLAEGDQIFNDPVVNYLPELASALQGHQDPINLVRWSDVTVGQLASHMSGIARDCKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2N2</accession>
    <name>A0A1Q5U2N2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2N2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2N2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64085" checksum="A76CF2237DE3E008" modified="2017-04-12" version="1" fragment="single">MSIKVKEVPVEAHNSVGKVERYHAPLRRAYEILREELKNENIDREMILQMAVKAVNDSAGPDGIVPTLLVFGAYPRMTEMDPPSPSVVKRAEAIRAATKEVRRLHAERQVNDALAMRNGPNITTTLDLPLQSDVRVWREKGGWKGPYKLLAMDGEICTVDMPYGPTKFRSTVVKPYHREELPEGEGEQRRIRAEDDQVDRTVDSEPVNEPDKPVEIQRRGRGRPPGSKNKPKPQTTVRRSTRGNPTHHQDLEDQFINTIWEGQDVAMALMTNKERADMELSIKLRNDGVITTPGLPFDQSRNEEIEGLIARGVFDFVRYDPVKHAGIRIFNSRLVNEIKGKATGTPFEKSRLVIQAYNDEGKGMILTQSPTIQRASQRVIVALAPSLSEKNISLSIRDITQAYVQSTTSLNRLILAHLPKEIKSKFSAGTIMVVRKPLYGIPEAGTHWWATYHKHHREKLEMVTSPYDPCLLISTAKEAFGVVGMQTDDTLILGSDEFAKLEAKELAEAKFSAKPKDTLSPENPLIFNGCVLTQKEGDVAVELRQKEQGKKLKLIDHKSKDLKQAYMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4F7</accession>
    <name>A0A1Q5U4F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4F7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009593">
        <property type="entry name" value="DUF1203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06718">
        <property type="entry name" value="DUF1203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="11551" checksum="51E614255448EA0B" modified="2017-04-12" version="1">MLLLQYNPFPSPQSPYTVPGPIYVHADLQDCIPFQCDGRVPEQQRRRLLAVRAFDEKNMMVGFAVVEGEELGKKAGEMLGEDGVGFLLVYYAGPGCFAVRVDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U724</accession>
    <name>A0A1Q5U724_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U724"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="96" mass="10708" checksum="1343BDAB07EF1794" modified="2017-04-12" version="1">MEKTCLFLGKVHLHPPRSASSGLYLQSGSGVDLSSLGACQQKSLQDKMERTRLDLGKSPPPSTPVCLQRPCVWNRDPASRPKVYQWCQQIVKQTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U756</accession>
    <name>A0A1Q5U756_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U756"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U756"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="167" mass="19593" checksum="29326F26074CF5BA" modified="2017-04-12" version="1">MTTYKPFSSTELLSAIHIDSEGNLFHLEDQVTEQGLLTLCKNFLTIHTQSNVWRFPHLSVIEYLEAKEGWSRSKAHYQVARTCLSYLITTYDRDFPELPLQTFDLDTDTAVRDEDIVDADKEIEPTELEESDHCFGKYHPFHIYVSNVGCTIPAKLRIQRRRHWRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Y2</accession>
    <name>A0A1Q5U7Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho-type GTPase-activating protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U7Y2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="742"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1316"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP08590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="145161" checksum="396242B3DDC4ACCC" modified="2017-04-12" version="1">MSQRRGSEEGSPGPSRNQPPPGAYPPLNTGLIPRDYLARSDMATRPHISPSPLQTNSLPQSYRRDDSPISQSPLSPRSTANSSPSQNRSPISRIANAPFPAPPSNSGHPMSQSPDMVGADQLDMPVRHGDGDIAKPPGASEPDRSAPSPVSSVLSAPGDRPTPRVMPRTSSIDSAISSLSSASQRSTFDAKSLSPADISNLITAAGSAEAVILHLLKEKHQAASQNSQLWKLVDKQRTLILGLNKDLDRAFKEKEKYKKKLKDLQDSAPPVPAVDTSIPRTILADTDPRASQTTIVPSSENKGGERGIEQSTAVPPIATSGLPRGGTEASPRSAGSLSSPIGPDGQKLPHPIRKPPPAPLNLRQGGHPREEIVDADSDSDYGDGRDAEERSSSDRGRRKTREEDDRDRETGLQKDMGAQGSVGAAKFEVPYGSQDRGGNPMVSRELVTRSPPNVGATGSLGSVLNSRPTPSASNGRTMVSMVSMASMPKSPGLPMSPRPEDRPIGSPLPRMPRDFAAQAGYNLGGIPISPRASNYPTSFADAQSMNGRPGGPIPSIDPTVKIDSPRSARFPNTSIYQGLVSDEYPGLLLPPNALPLIQVRVSSSRLRPSRNSYMVSKPLDEEPVFTLSVISRSEMAELWRVEKVIASLPQLDHQIRQLASFAGKLPDRTIFSGHSPAKVDARRAALNTYFDSLLDTPMDERAALVICQFLTNDAIEPRDDETSLVKGSGQAKQDMPRGPDGKPRKEGYLTKRGKNFGGWKARYFVLHGPELKYYEAPGGPHMGTIKLLHAQIGKQSQNSTSQSNSPPGTEEDTDNQYRHAFLILEPKKKDSSALVRHVLCGESDEERDQWVDALMEYVEAPSSDNESRGNASSKQTQSKSSSAGSKNKGSKDGNKRPGRGVDSPDQEGGGAVQGFSFDDTVAAEPPIIGSSLEQAPRSPHIPGLSTDFRDLNQSAADPTMQSPKIISGPTNATVIQDVGAWGNKPTATTTSVKEKKRSIWGFRTRSSFDLAAQASETAAPVERRENVKPVFGIPLAEAVQDCGPIGVEADLPAVVYRCIEYLHSKDAALEEGIFRLSGSNVVIKALKERFNNEGDVDFLTGDQYYDVHAVASLFKQYLRELPTTVLTRELHLDFLRVLELDDKQKKVLAFNALVHRLPKPNLSLLRALSLFLIEIVNNSDVNKMTVRNVGIVFAPTLNIPAPVFSMFLTDFDSIFGDAGSNSPAPAVELTVEHSLSPDDVRSPRHQMFSDIPTPSYNQTSFRGPGDGSGGHVDNSRAPHETGFIPMQPSYEQPGYRNDAYNQHPGAPSQYHSLNGMLNPNSDDTRSAKAKRRESSMLFMESSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U817</accession>
    <name>A0A1Q5U817_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC multidrug transporter MDR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_5599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U817"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U817"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000095">
        <property type="entry name" value="ABC multidrug transporter Mdr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="186"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="507"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="749"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="793" mass="85372" checksum="06893CBEF87B00A3" modified="2017-04-12" version="1">MRGLRLPAWASGVSPRPALRSQSAVLRDSLPLASRSFSQIGESNGANRLYTTASGTLRDRVGSSVRPAEVPLLLRQHNSQYTSSTSQIVSQIRSLSSSPHLYQAKPPSPSSPPSNSSQANTHPVPEKDGEDAEDKGFELSERAAQAAQVNLRAKLAKDGTSGKKSGFAEIWRLFKIARPEAKALGFAFFFLLVSSSITMSIPFSIGRIMDGATKSEEEGGGKLFGLSIPMFYTALGGILLVGAAANYGRIIILRIVGERIVARLRSKLFRQTFVQDAEFFDANRVGDLISRLSSDTIIVGKSITQNLSDGLRAGVSGVAGFTLMAYTSLKLSSILALLLPPIGLGALFYGRSIRNLSRKIQKNLGTLTKIAEERLGNVKTSQSFAGEILEVNRYNTQVRKIFDLGKKESLISATFFSSTGLMGNMTILSLLYVGGGMVQSGAISIGELTSFLMYTAYAGSSMFGLSSFYSELMKGVGAASRLFELQDRQPTIHPTKGIKVESARGPIRFENVSFSYPTRPAVKIFKDLNFEIPQGTNVAIVGPSGGGKSTIGSILLRFYSPTGGRVLINGNDIKDMNAKSLRRKIGVVAQEPVLFSGTIAENISYGRPHATRSEIVAAARKANCQFISDFPDGLDTHVGARGAQLSGGQKQRIAIARALIKEPDILILDEATSALDAESETLVNSALAALLRGNNTTISIAHRLSTIKRSDTIIVLGPDGTVAEQGSYEELSSRPGGAFTKLMEWQMSGGDQVPAPATRAVPPEELYKLEPEVEEQELEEEEEVEESKSQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAD1</accession>
    <name>A0A1Q5UAD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAD1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="220"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="537" mass="58532" checksum="BFE51B87990E07CC" modified="2017-04-12" version="1">MTKVEEQEQRLGLMAQAERIAGEFSLSAEHVRRVTRHLVCQMKDGLANERPWQLPAYLQSVPTGTEKGQFLAVDLGGSNCRICMAELHGDSTFTVLQSKHKVPPSVMVNESYLPLFDFIAGNIAEFLNAHLDPKSPSPYKLGFTFSFTCEQESLKGGRLIHWDKGWDIPEAVGRDPCVMLQEAIDRIGLPVLVTVLANDSVGTLLTRSYSSGQRVSTLGAVIFGTGTNAAYVEKLSNVRRLKNINDDTEGIMVINSEWGSLDDEMKVLPRTSLDDELDAASVDPGYGMLEKRVSGLYLGELLRLAILQLLRGGAFRMTVAEESCLFRRDGIDSSLLSNLARTDANDVEGAVALLQDTLSAKTVSKVDAKAIKLISEAIARRAARLAGASLAAVIIKSGRLERHPNRTTPRIPSLKTSILSTSFKSFYNYAPLLFRHLLDFVRLICKRPSWMLPKHTTGAETSSLCEEIIDIGADGSLIESYPTFEADMRGAMRDVSEIGVKGEKRIRISLTKDGSGVGAALMAHAASLAEVGGSVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAM8</accession>
    <name>A0A1Q5UAM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000506">
        <property type="protein sequence ID" value="OKP09526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044411" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14676" checksum="0FE2245CF7A75E46" modified="2017-04-12" version="1">MALLARLFMASFLLFDGPHVSVAGEVVTVTSTSIATAFSDCTCALTVSDHLTEYKVSTTSVNVAPPFTTEPTRSAFPATSVSYPNWSTTSEPTRTSIIAPVCRPIDFGSSYSRIFSFDLPDSHQKPDIYRSIPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAS9</accession>
    <name>A0A1Q5UAS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAS9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAS9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="226" mass="25917" checksum="387F1D4AAD5F2E94" modified="2017-04-12" version="1">MRQSLTTIVSSPDEPYFWTIRNMWTVNTHVLTATIWLLFELIFSKDQGPLFDSREIKNLALKSARFLQINQSRSRIAKRGQSLINTLLETYDHIENGHRAHFDLKNIMSRVERDEDCLDGDSNDLHFNYQANDGSGSVVDWLSRDSATFGYESQEPREERKVLACSYHSGQAQAELDRPAGLPDWVMHDTLSHSEAPADLSGEEERATNTYIRRIAQGQQHYQGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBA2</accession>
    <name>A0A1Q5UBA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000462">
        <property type="protein sequence ID" value="OKP09754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBA2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBA2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="47912" checksum="D9021295FCF6A68B" modified="2017-04-12" version="1">MSYPVDVHFVDGIPDLVAYYLRLLSDITPSLLSLLYLLCTGSVFFDVVHHMLHRCNKSSHPLFRRLARVHHYHHLYFTRHMNFDERYLQQNRFQALPLELALQIVGSTLGYLFANYMTPNGLVWCTRNHLLSIIGFETLRSTFVILTCGRDSNHLIYKTAPKDTNWILVGPEFHALHHVYPDRYMSSFIKVFDRIWGTAYSFRRKRFTITEGSGAFTQGIIKDLEREEGVACIRKLTIGTDWDHHDFGKVIPTLSNTDVLILAHAYDGEDALGSNCDSATRFIKLFKQCRATRPACQTLPEVWYIGREIDFHPFWRNARPQRDSQSKRRTFLPHARSCFDDPDIIYRHIVLPSFLSSVGNAVFSADWAARCAMWWIRRGARYIPVTYTGIAWLDYFKFMYRIPYATDADQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBJ3</accession>
    <name>A0A1Q5UBJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBJ3"/>
    <dbReference type="OrthoDB" id="4355661at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="779" mass="87335" checksum="102A852384F77FEF" modified="2017-04-12" version="1">MASSQRPGGSKPSSGQGKARTRRSKRTAALLKQQKDEVLRRIPQLELHQAYSDERAEHDATKAIASRLRLQHNDLVKRLDESETAVAMAETRAYENEKELIKLQESLSKFRMGAQNNEIWIEVMADENQRLEEANARMVARTAVREGEMSQEIELMEKRARQLEQSLSLAYKDVGEYGVLFQKNTEDWAELGRFLDDHMSEDNERIQELQRSVMEYSNSMDHFHDEINRLFQAAEVRIARNRLRRDRTGRRDGLLGGQRDGQISRPGSGMSENLHHSLMLLGSPDSESNPGNSTYTGLSSEESIESWPLMPPRQIGNFGTVSFEPMKSSDAELEFANDEPESLDSLAPLADDIQNGFAVFNATGKRRSSGSTRGDDLNSYLDFKHDHDKISMYEHFVQDWKENSFISQGLHGLPYGNEGRGRSLEQMLADGISSPEETDSESSLVESWSIPSSTDPSSLSGSRLSNLSFESWNHVREQQSPLQMVHERRGSNKARLESSPVHDEYFANGFIPPLNTSRKRIRLAPPPPDSNTGDADEANDPSTDSFDVDVQANIEATDCEVPQGASETRTLSDDRTQSSFTVDQRQGNSVVGQSQPKGIQTVNDPLLARLDNLAASSLQELVLAPKGRLSLRGKLRSLSVGDLPRIVAADGATLFERMPGSWPREAISHADVKPIVASEIADAMLQMFRASVENAILVGINLLHLLNPAHPKCIVYPGLMVLWLWQAYEEHMEWKRWEGANERYFVQQLRNRYASHAGCVDSMGFGLSQWLAFDRSSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBT7</accession>
    <name>A0A1Q5UBT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBT7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11709" checksum="355CE51B40016977" modified="2017-04-12" version="1">MTKGRSGRSAKNVCNLLNHIPKVMRCPMFHEVLALGESVQNRSNNIKGMEAQWQQDFKPVLRRSVDACQCNPVMIVNKIRCQYSGPQINLRQQVDRGLRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC01</accession>
    <name>A0A1Q5UC01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar calcium ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000412">
        <property type="protein sequence ID" value="OKP10004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC01"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="194"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="269" mass="29125" checksum="7B5861FF3F7565C8" modified="2017-04-12" version="1" fragment="single">MHRYLRQAHKLAWYDQDGTRSTYNPFKRYVRGPIISVELGEQFPRSRSMGDLRLPDEPTQQAGLDGDFPRPAHAYTFPAEGTGSLKAGRTSLKTSINCETDVSIAQAEGEITQDAEITQDAEIQRRRHGDFDGILGSAGEVVQSSGVGDGKDLDGPKFSFGSQIRATLFNSWINVLLVAAPVGIALHATKANPIVIFVTNFIAIIPLAAMLSYATEEIAMRYGELIGGLLNASFGNAVELIVAILALVKHKVVIVQTSLIGSMLSNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDK3</accession>
    <name>A0A1Q5UDK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDK3"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="55158" checksum="ED0A7826015AC7B3" modified="2017-04-12" version="1">MPPFLPPEILGMILSFIFDIESLLALRLVNKVWRDAVDYSVRKPLYVDLLNKNLVRFYDATKLEENFRNQVRTLIWNLPDRPIWNCFSISDPLSQDLEGLSGSNRLQLLMTMVVNMRIFEGRDFFFPNLTHLAIHFRPPPIFDTTCLCSPAMKGYHLKDVFSKLIMGLDGFHGLSELSLLNIPIEFSLPFWISPANVDQWLPVGRIMREFGLKSLRMSYLAPKIWPYRNDDRARAPSARANHLLICTVKDTLRHLSLSNWGFYMKNSPGYLADELHLPHLQSLELRSCGFTSSQTLEWILSHSDTLRSLKFDDCAIIYSMELAPGSRADYLLDDINLGVEGGRVYQLYKLLWAAWFQRLARGLPHLQQFDFGSSRVRAPGERGPKFKSETLVGPRFGHTTDFLFGLFPDRYLEMKDGANEYPWVLRLISKLRKFEDRPVADEADISALRQLLAVTGQVVQENDTSNHAAKVVDLMGVIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFI4</accession>
    <name>A0A1Q5UFI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075018">
        <property type="term" value="P:positive regulation of appressorium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="53"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="44501" checksum="3D09D68B95E4CA95" modified="2017-04-12" version="1">MECFPFSRALCWAFGPINRADHEPQSHRTGTMVQQNLAQGGSRKISFNVSDQYEIQDVIGEGAYGVVCSAIHKPSGQKVAIKKITPFDHSMFCLRTLREMKLLRYFNHENIISILDIQRPRNYEGFNEVYLIQELMETDMHRVIRTQDLSDDHCQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNANCDLKVCDFGLARSAASTDDNSGFMTEYVATRWYRAPEIMLTFKEYTKAIDVWSVGCILAEMLSGKPLFPGKDYHHQLTLILDVLGTPTMEDYYGIKSRRAREYIRSLPFKKKIPFRALFPKSNDQALDLLEKLLAFNPAKRISVEDALRHPYLEPYHDPEDEPTAPPIPEGFFDFDKNKDSLSKEQLKLLIYEEIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG80</accession>
    <name>A0A1Q5UG80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG80"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF104">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="93"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="553" mass="63248" checksum="199A1B9DBFB7347D" modified="2017-04-12" version="1">MTIEETKNVGPGPNDYDVKAVPQVTATSDSESSSSLGGRRGQIKPVDCAFDTTEDPRYYKPIPEYEGAHRWDPDFEWTEDEEKAVVKKIDWRICTFACVTFFALQLDRGNVVQATSDNMLGDLGMNTNDYNTGQTIFLLCFLFAELPSQLISKWLGPDRWIPVQMVSWSLVAACQAFVKNRSTYFVTRALLGLLEGGFIPDTILFLSFWYKSKELPIRLSYFWVAYQGTTIVSAFLAFGFLHIRQADGTGGWRYLFAFEGLITGIIGIIAAFWMPPSPTQTAGRFRGKEGWFNEREEKIMVNRILRDDPSKGGMHNRQAVTPRMLWHALKDYDMWVIYILGLTWMIANTPSASYISLQLKSLGFSTFHTNLLTIPAAVIFICNLLLWTWLSERFNQRLLLGVGSEIWAIVLLIALEVLPAHVSPWTRWTLLTLLLGMPYVHAILVAITSRNAGTVRTRTVATALYNMMVQVSNIIGNNIYREHDKPYYRTGNKVLIALASWSLVMFIIAKFYYVWRNKKNAAIWDNMTSEERERYVVENKDLGNKRVDFRFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGB5</accession>
    <name>A0A1Q5UGB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RHO GTPase-activating protein RGD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGB5"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000041">
        <property type="entry name" value="Rho GTPase activator (Rgd1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="40"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="471"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="664" mass="72099" checksum="E5EC8B2E0E47E0B3" modified="2017-04-12" version="1">MSDTALPEPTALPALSDAPPSSAGRSSGTAAVDLSHPPQAAISDELKARLDKVIYSEIGITTLLARLKQSVASARDFSSFLKKRGSLEEEHAQGLRKLSRAVNDAAQRTENRQGTYSSSYKDIHHLQERMADHGLQFSVSLQQMADDLHELSTNIERGRKQWKQTGLAAEKKVIDAEAQAEKAKAKYESLAEQYDRVRTGDKTGGKFGLKGHKSAAQHEEDLLRKVQNADSDYAAKVTAAQAARQELVSTHRPQAVHNLQQLIAECDSGLTLQQQKFATFSEKLLLGQGLCVSPMKTENGAIVPKSLAEVVRQVDNQKDFHDFILSHEGSPGAISGPEVKYERHPTLGAGAAAVPAAATPSQSSTQAKRQSTLPQTFSQHNVASPSPQPAPSSTDRFQPLPYPTQGEPISALPSQPPYPVSGPPAHEPALAPVHPPAPMKGGSAPLMAGPPPMDRATLQASLPPLKPVFGVSLNDLYTRDGTAVPFIVYQCFQAVELFGLETEGIYRLSGSANHINHMKAVFDNDASKVDFTSPEDFYHDVNSVAGLVKQFFRDLPEPLFTSQFYNQFIDAARIEDDTQRRDSCHALINSLPDAHYATLRAVILHLNKVQEHYTSNRMNAGNLAICFGPTLMGANSGGNIADAGWQVRVIETILNNTFQIFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGL7</accession>
    <name>A0A1Q5UGL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGL7"/>
    <dbReference type="OrthoDB" id="10503450at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="9633" checksum="ACE9D7960C58EDA3" modified="2017-04-12" version="1">MPTSKESDVQSGVHPVLFSGVHPSNHMEYTPNLAQENFFLSNTASTPSFLHAEQISPNSATLSGTDAAVLTANLETALPGLRPLNLLASAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGV5</accession>
    <name>A0A1Q5UGV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-tRNA hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGV5"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010173908" description="Peptidyl-tRNA hydrolase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28368" checksum="CAAC99E258F2C78B" modified="2017-04-12" version="1">MRFTSLITLLPALALAQEQVPLADRVQGWFNKAKNLVPTAVPADPIQKMAEKVSEKRVTDVTMRNWQSLLAPAEDAQDWYIYITGGNKTCFGRCDIADKAFKESVLLFSADPTAPNLGQVNCEEERVLCATWSAGAPSVFYFQVPQAQPEGQPRLPTPLHVVYMNTTTVTPQELYQVHSKKNFEKVPAYEGAFHPTDGLLAQYQLNVAFGYAIWAIGAIPSWTMMIAISFFSRTVMGRRMNNVGQPRRPAPAGSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH01</accession>
    <name>A0A1Q5UH01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH01"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="301" mass="33366" checksum="41C59745C400F780" modified="2017-04-12" version="1">MHEESGVRHAVNSFYRNLDLQRSRCSIVPNQPAAWHLKHTSINLSAFAATVLVKSGKISPDMLVLHRPIEYDTFMDPANPLTAGALVLFGVLTKFVTSFVDAPREIVSDLASAVRATRHPHEHFDRREACRAAISSLDQASPEYSIESEESPIENETWQLRIENNEQGAGEPREDESTQEDTGEEENRDHVNEMARVRSIERKRSLQLDKAKTMSSSIPPSKPSRFIVLHEAALHGSKMSKKLMKVIIWLPADFSLGMARGFHNAPKLYHDLTVVDTPQVVGLQSGLSAAGKVSTSIPAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH28</accession>
    <name>A0A1Q5UH28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Checkpoint serine/threonine-protein kinase bub1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH28"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH28"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="820"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1215" mass="135274" checksum="825FEF3FFB9E658B" modified="2017-04-12" version="1">MAASDDLIDFDIIEAQKENVQSLPGGRSARELARIFSGGSTSDKFAAPSPNDTRTINGAIRQEYENELGSIGESDDPLDVYDRYVKWTLNAYPSAQATAESGLLPLLERATKSFLSSSHYRNDPRYLRLWMHYIRLFSDAPRETFAFLARHNIGEGLALFYEEFAAWLEGAGRWTQADEVYRLGMDREARPVERLARKYSEFQQRYELQSQDAGPGPSSPALPAVRPALAAKMDPFASTETAANPQASRSAAPPPGPAKTKSGKMKMAIFSDAEAAQSSQPATSGQTKGWDSIGSMRERRKENEVEAKPWVGETLKAGKKPAPTQKMAIFRDESNSNPPSEQPSALNHIPEHHVREAVNPRTGRRERVFVDLEAVYPDHKNPAHEISFEELRAMRRGWMDKDWRRQKEPLQQISGNAPGEAPPAKLKIFKDEPLSERPRQMLATDEQPSQSQHQDGQYEGKAGKARKFKVQGETQTIKMKFDSPTSSKARRKSTREPTMTMHTRAATDEIYGIFNQPLKAEMDDAADSLYGSEYEDEDCASTVDSTGTGHISAASSDFGDDETHTFHKSYDDTEYGDGNTTRADSVAGGDWTDFSVSKDVPGAESAEVTSHSVISQGDVESQHSTPEKERFIPRMPDDYNPPYGTYRDPAIMAQNRLPFMTPIVERTESSISMTAARSLHNAKTPCKPRSPSGVPQMGDLLSSPFGTTTPYHGDHTVGSAVDVPFSPTAFKALAPKSRRREAIIKDLQCNPTDKGIRNTILNSLEPPLASYPGYHGHVQDSNYASMIQKFVKAHSRKSKSADDERSETPILEFPGAERSYIIRRELGAGAYAPVYLAESVDVDSQQSYSSDTDEENIKSNPYDSARYSFEAVKVENGPSSAWEFYMIRTAHERLRHARKYSRAVDSIVRAHELHVHQRESFLVEDYRGQGTLLDLVNILRNDSISSTHPSDGGLDESLAMFFSIELFRTIEALHATGILHGDIKADNCLVRLDDSDPPTKALSLLDLGDTSTFTDPRDTPAYAPSGAFNWRSKGLALIDFGRAIDMNAFPSNVQFLADWETGTHECNEIREARPWTHQIDLYGIAGVIHVLLFGKYIESAPVRTSDASASAAARTYRIRESLKRYWDRQIWSDVFDLLLNPGGERWVCMEMEDAVESVPGVGAEGPVLPVLKSMAFVRGRMEEWLVGNAEKKGLALQLRRIEAVLAERKKKLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI42</accession>
    <name>A0A1Q5UI42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI42"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010334054" evidence="2">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="73" mass="7991" checksum="4D5D22F34E6ED0D3" modified="2017-04-12" version="1">MRYTLINGLLLLAISPFTSLALPVDPNNQGGQWDPSGQYRKGHYDSNGHFIPEEGSNQVGGNENGQNYQNGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI76</accession>
    <name>A0A1Q5UI76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pre-mRNA-processing ATP-dependent RNA helicase PRP5</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pre-mRNA-processing ATP-dependent RNA helicase prp5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_2299</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="614"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="819"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="360"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="983"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="73"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134593" checksum="FBA3A6949AAF8FAC" modified="2017-04-12" version="1">MARHGDPRSPSPVGSTYSSSRRNRREDDRFDRNRRDEGRGYRRSRSPEVGNTRTYKLSSSASSLTHFSTMQRRYRDRDHGRDRDGYRRRDRSIDRREEDSYRPNRRDRSRERRRSRDRDDDRDHRRRSRDRDYRPRKDDSRDRDRRRTDDSADLKHKARRGDSRDRGAIGRSRSRTQEVRSHDHPFTSGTHDAYYVRQPSKPTTPAPAPAAQTDEQKKAERLAKLELWKAKQAAEREKKQQEQAAAGGGRGILDEIDRRSGLSPAVGSPQAPVTPTDTASPAPYAGKFDPKAIAKSAASNGTAVTPAVLGIDVAVPQTTKAPVRPLAAPSAPASAPLKAKGNVSGFGLGSKLAFETDKPSATRTLGFGEEESTRKKLERLPTPPLDDGKDTIVGADDAGDDDDVDMQDGDNEEEAAAAARAAAERREERLQIQQSEMNADIHMEDASNQQAESTEMEVDEDVDPLDAFMSELADTAPPKKKIGATYAKKKATQPQAMFSDDDDVDLTAVGGEDADDVLAMASKKKKKEIPTVDHAKVEYEPFRKDFYNEPSHLADMTEEEVANLRHELDGIKVRGQDIPKPVQKWAQCGLGVQTLDVVERLGYEGLTSVQAQAIPCIMSGRDVIGVAKTGSGKTMAFLVPMFRHIKDQRPLGNMEGPISLIMTPTRELATQIHKDCKPFLKALGLRAVCAYGGAPIKDQIAELKRGAEVVVCTPGRMIDLLAANGGRVTNLHRVTYVVLDEADRMFDMGFEPQVMKILANVRPDRQTVLFSATFPRNMEALARKSLKKPIEIVVGGRSVVAPEITQVVEVRNEDQKFVRLLELLGNLYSDDANEDARALIFVDRQESADNLLKELMRKGYPCMSIHGGKDQIDRDSTIEDFKAGIFPVLVATSVAARGLDVKQLKLVVNYDAPNHLEDYVHRAGRTGRAGNTGTAVTFLTDTQERYSVDIAKALKQSGQEIPEPVQKMVDNFLEKVKAGKEKASASGFGGKGLERLDQERETARMRERRTYKTGEEGEEDEEKDEKEKKADDERFNKALSAVQSAAAPAPALLVGVPKGIDLDGKITVHKTEKDPNAASKNPLDKVGSAVADIHARLSRAGVMRSGVPIDNRGPDAGAFHATLEINDFPQKARWAVTNRTNVAKILEATATSITTKGSFYAAGKEPGPNENPKLYILVEGDTEISVTNAMRELMRLLKEGTVAAADSDARAPASGRYSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIH8</accession>
    <name>A0A1Q5UIH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">RNA-binding post-transcriptional regulator cip2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_1999</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIH8"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02639">
        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034069">
        <property type="entry name" value="R3H_Cip2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="157"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="323"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="244"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="556"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="626" mass="68242" checksum="BC88C70D7707BF49" modified="2017-04-12" version="1">MSYQQSDMYHDPSARSPGSQRHQQPLHRQPSRQFDAYGPMPINPYEDQMARYESARLERLNPSLQQNNNSYAYDLSGSQTWNPNGFANAQSLGGIRSASASLKPNARGRTGLPTTWLDQQPGMPNAFANLGPGPIQSSAMRPEASASSEGDDELIPTAIVIKNIPFAVKKEQLVQLMTELNLPLPYAFNYHFDNGVFRGLAFANFTSAEETATVIEVLNHFELQGRKLRVEYKKMLPLQERERIEREKRERRGQLEEQHRPMASSQLQTQSSMSSLTSHIPATSPSPVSQRGQKLGKSIRHFPTSDSDLIAHQHEQVEVDLNDSQTLSYYSQLLLFKEDTARDSVIFPPNLTPSQRRTVHTLAHNMGLGHASRGNGDQRQVQVFKVAAGTNVSPPMSAIPPAGQPGDGGRRGLNRAATIDFSEARNEGGPGAFNTLRGQNSSFLGVMDSPGNFANTQNLRAAKSFADLRSYTPSPVPSSASFPAALQSNGTRLQYEGAQTGTSNTPTLTSAPSGSSLGMQRDDNLLVNSLGGLSLGTGIGGPNSSPRRLRGMFSWEQDSQSSAAGTIGSNRGMGMGFDNTQQERIPIRQPRGPTPEKGTGFRRQNGHQARGSDELRATSGVEIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIL3</accession>
    <name>A0A1Q5UIL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIL3"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="266" mass="29177" checksum="1D6F1AC972A9216F" modified="2017-04-12" version="1">MSGYDRALSVFSPDGHVFQVEYAMEAVKRGTCAVGVKGKDIVVLGCEKRSALKLQDTRITPSKIANVDEHVCLAFAGLNADARILIDKARLEAQSHRLTVEDPVTIEYITKYVAGVQQRYTQSGGVRPFGISTLVVGFDKNDSTPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNHQDDMDREQTIQLTIKSLLEVVQTGAKNIEVAIMAPGKRVEMLPDDQIESYVKSIETEKQEEAAKKKTSRGGAATAAILTRPGGETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIN1</accession>
    <name>A0A1Q5UIN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UIN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000030">
        <property type="entry name" value="Histone acetylase complex subunit Paf400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2642"/>
            <end position="3197"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3512"/>
            <end position="3854"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3851"/>
            <end position="3883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2006"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2292"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3202"/>
            <end position="3338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2299"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3202"/>
            <end position="3213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3221"/>
            <end position="3314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="3883" mass="441562" checksum="FC70E71A6D6CE670" modified="2017-04-12" version="1">MDRNIDIYASKLGDEKLDIKVRANVATELRDSIEPLCQGASYPVFLAKLWPVFKTILKGDPVFFSMSYEQKLRNCILETLHRLPTASPDVEPYAADMVDVLMDLARIENEENAVLCMKTIMDMERNQAKATAARVQPFLELIQEMFQTMDQVVRDTFDTPNQATPSGMPSTPNTSAQNFQSPRPSSPATSVSDLGPDQQASNVILKGMQSFKVLAECPIIVVSIFQTHRASVAQNVKLFVPLIKSILLLQAKPQEKAHADAASQGTIFTGVCKEIKNRAAFGEFITAQVKTMSFLAYLLRLYAHQLQDFLPTLPSVVVRLLQDCPREKSGARKELLVAIRHIINFNYRKIFLEKIDELLDERTLIGDGLTVYETMRPLAYSMLADLIHHVREYLSRDQIRRTVEVYTKNLHDDFPGTSFQTMSAKLLLNMAEKISRLEDKREARYFLIMILDAIGDKFASMNHQFNNAVKVSKAYKDSRKDTEPPVENYLAEKDQPPDWDEIDIFSASPIKTTSPRDRGGDPVSDNIFLFRNLINGLKNIFHQLKNCNPDDVQIDSNSVPINWSEVSYGYNAEEVRVIKKLFHEGARVFRYYGVDQSPPEMNYSSPFDFLASQYTAPMTREEKELLESFGTVFHCIDTATFHEVFHSEIPYLHELMFEHGALLHLPQFFLASEATSPAFSGMVLQYLMERIHEVGTSDMTKAKILLRMFKLSFMAVTLFSVQNEQVLHPHVTKIVTKCIELSVTAEEPMNYFLLLRSLFRSIGGGRFELLYKEILPLLEMLLETFNNLLLAARKPQVRDLYVELTLTVPARLSHLLPHLSYLMRPIVVALRADSDLVGQGLRTLELCVDNLTADYLDPIMSPIMDELMTALWDHLRPHPYNHFHAHTTMRILGKLGGRNRKFLNHPPELSFQQYSDDNPSFDIRLIGPSEKRPFPVDIGIDLAIGKLMEVPKSPATKTSDIYYKQQAYRMLSSHLKLHIGFENLPDDLASLIRLHANDLFEGKAGAMVDILEKSERSASIPKKVVQEATVKKLLKACIFATTVPELEPAASAFVADVSKHFAIVEVGRALAQARHNRKPFDVANGEGPVYLDSRVLAEAIVECLSSDSAHVREAAEQAMLVVKEAAGVMFGAPEKGSKLPFFQHLGRVFCHSCHSEEWFTKAGGSFGIKLLATKMDLGDSWLYERHVEFSRALLYVIKDTPADLPASTRVQSQETMTLILQRCGKLIPKDDLKNEKSRLFSLCGLFVYELGHMNKHVRETSKLCFSTLKEELGCEVHELIHPVRDRLLQSIFNKPLRALPFATQIGFIDAITYCLSLQNEIVSFNEPLNRLMLESLALADADDDSLASKPNEFKNADMIVNLRVACLRLLSMAMNFPDFANTPQNTSRARIISVFFKSLYSRAPEVIEAANAGLKDVLTQTNKLPKDLLQNGLRPILMNLQDPKRLSVAGLDGLARLLTLLTNYFKVEIGARLLDHMKVIADDMTLQKVSFSLVEQNPSMKIVAAIFNIFHLLPPAATSFMENLIDKVLDLEKKLRRTSHSPFRKPLVKYLNRYPKESLAFFLARFKEESYGRFFGQILADPESDALRNAVVADTENFTSTAFGLDATDEKRNTAAINGIYIAHSICSYSSTKRWLVSHADLRSKLLSSGRELERKLRSDSLPPDERLRVEQAEDQLMDIFTVYLTEASHDLDFLFEVIDGLSADEFKRTLALPKFIYSHIIVNESIDYRRSVIMRCLDLYGQRACSQKTKTYAFRHLVNPIFAMDVQTTWNSPANTPKLMDKSMTESIQSRLWKPQLADLSEESSQAGVDHSRMELLQLSALLIKYHHQTVQDSRKDIIKFAWNYIRLEDIINKYGAYVLISYFIAHYETPFKIVIQVYVALLRAHQNEGRALVTQALDVLAPVLPTRTAGNQGPEARYPLWAKWPRRILAEETANLQQVMSIFQFLVRKPDLFYESREHFVPLIVPSLIKIAGPPNTSNDSKKLALNLIGLIWHWEEKRVQAITTSPTVPNGALESPNAKKRKLEETHETASASPSLGPPPSRERSEYTVPPELRAALIKYLITFITTIPERFVVPAARIRHVPTNKQPPPQPVPIGEMVNKAVSLLRNLLSKEYWGDLDIDLYQKVTEPILAGEKADKPDEKQITPMVNTLQVLRVLIASKPDEWITARLATIQKLLEKPLKSDNPEIQDCLHGLEDDLDVSPKLPPPVRRVLEAIPDDQPDDEDAMDTESTPSEFATYLSAIATETLSASNYTAALNTLWTLSKLKPAEIDTHIPAVMKAFSQKLAKEHVAASTPQNGQQPQQGQKPAEGVPDMQEIELGVDLIFKTIELISVRMSHLGDQRRPFLSVLASIVERSQNNKLCSKVLGMAEEWIFHSTESWPTLKEKTAVLHKMLLFESRPDQVMLKKFLDLVIRIYEDSKITRTELTVRLEHAFLIGTRAQDVEMRNRFMSIFDKSLTRLASSRLSYVLTCQNWDTLADSFWLAQASHLILGCVDMNTTARLHQDDFTVYPLSFLFAGGETDARKADIMVESQLENFVADRRRFMSDIGDVRVRDLIEPLSQLQHTDSQVAYKLWTTLFPIYLSTLTKEDRIDLEKGMVTLLTREYHQRQLDKRPNVVQALLEGVVRASPRFKVPPHVMKYLSRTYDAWYTAATYLEESAIKPIIDTPTVRESNLDALVEVYAGLQEDDFFYGTWRRRCKFVETNAALSYEQQGMWDKSQQLYENAQIKARSGAMPFSQGEYFVWEDHWLICAQKLQQWEILSDFAKHENLNDLLLEAAWRNIENWQSEGTREQLESLIKSVSDAPTPRRTFFQAFMALLQYHMKKENMQDFNSVCDESIQLSIRKWLQLPKRITNAHIPILQHFQLLVELHDASHICGSLAQTNERNLDTKSAELKLLLGTWRDRLPNLWDDINAWQDLVTWRQHIFQLINQTYLSLLPPQTNNVASNSYAYRGYHETAWIINRFAHVARKHQMPEVCINQLSRIYTLPNIEIQEAFLKLREQAKCHYQNPKELNSGLDVINNTNLNYFGPQQKAEFYTLKGMFLAKLDHVNDANEAFGVALYYDLRLAKAWSEWGQYSDQRFKSDPSDYELASNAVSCYLEAAGLYKSAKSRKLLSRILWLLSLDNDEGQIAGAFENFKGDTPVWYWITFIPQLLTSLSHREARLCKAVLVKIAKLYPQALFFLLRTNREDMLSIKKQHDQKQEKLNKVRQAQQGGSSPSTKPPTSGDTSSPAQKAPASAPAPSASPAGQAANLPTAQSPAQAAQGQSPAQPPNAQVQASPRQGQGQSPIPGQPQAQGQQAQGHLQVPGQTGPLPPNQGAASGESTEKEPLRKPWEYSDEIMSGLKTAFPLLALSMETMVDQIHKNFKCPPDEDAYRLIVALLNDGLAYVGRMPGSYAQDFKLPPATEANITRFAETILPAHIRKSFEADFVVKKPTMHEYIQKLRRWRDKFEEKLDRRPQSGFLESYSPHLSEFRFLKFDEVEVPGQYLLHKDKNQDFVRIDRFLPDVDLVRGIGVCHRRLKIRGHDGSIQAFAVQHPAARHCRREERILQLFRIFNGLLAKRKESRRRNLYFHLPLMVPLAPHIRLVRDDSSYISMQGIYEDYCRRVGMNKDEPVLFTMDRMRSLAETKQNVSSTVYSYSTVVANTPKRTADQQQVLRTEILTAIQDKWVPSTVVLEYFQNTYPNFADFWLFRRQFAYQYAAVAFMTYVMHIGNRYPNKILVSRSTGDIWGAELIPTINPAKAIFYNPEQVPFRFTPNIQTLLGPIATEGLFACAMMAIARCLTEPRHELEQQLSVFVRDEMMFWATAQHRGNLAVPQLRELVYNNSEIIVNRAVSLASPPEGNLPANQTTIDLVSRAVNPQHLASCDALWMPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ00</accession>
    <name>A0A1Q5UJ00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000209">
        <property type="protein sequence ID" value="OKP12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ00"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ00"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="39093" checksum="B538B9B0E9A56D3D" modified="2017-04-12" version="1">MTFIDPPEEELQLTSEEDPRKWPTWKRIWISVGPLLGVFSLTSGNSIYVAAVPLVNAEFQVGSTLGMLPITLYTLGLALGPIISSSTSEVYGRRPVYVLSLLGAMAFNAVGGSASNFRTLAVARLLAGITGGPMIPVVAGTLNDLWDTPSEQIGTRLMGLFACSIAWGSEIGPVMGQPIIEVSGNWRWTFWLSIILLGVSCVVWLNPETFGPELLRQKCRRLGKPPPPRGSLKDNLKIALGRPLHMMIVEPVIVPTSFISAISLSIVFFFYVAYPFIFESIYSFTPHQVALSFLSLLIGSALGLVIMIFINKRLHKKAEMLARTRRLTMKPEEHLYHTMLGGILLPLSLFWFVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKG0</accession>
    <name>A0A1Q5UKG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKG0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="12928" checksum="D2268F57DB731BD6" modified="2017-04-12" version="1">MNLQSGLYAEKKGSMEDLTEGKFSYPVIHSVHAAPGNTELVDILKQRSEDDAVKLRAVQYMESTGSFQYCRETLAQLTKQARSHVKELEMSLGPNKEIHGILDLLHVPTSNEKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKJ6</accession>
    <name>A0A1Q5UKJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKJ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="150"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="365"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="57682" checksum="223F261356B761BA" modified="2017-04-12" version="1">MADGYARLTGKPQAVIVHVDVGTQGLGAAVHNASCGRAPVLIFAGLSPYTIEGETRGSRTEYIHWIQDVPDQKQIVSQYCRYTGEIKSGKNVKQIVNRALQFATSDPQGPVYLMGAREVMEEDIEPYQLNQSNWGPVAPAALPPSGIELITSELAAAKNPLMIVGYTGRNARSVTELVTLANHFKGIRVLDTGGSDMCFPADHPGWLGLRYPGHDLVETADFILVIDCDVPWVPTQCKPSASAKIIHIDVDPLKQQMPVFYIPSMATFRADSATALRQLNQHIISNNSLQQFTGSSENNAMGQQREADYAKRRKEIADLAVVPAGGDSAPLNISYMMAQVRKGVPFDTIWAIESVTLTHQVSDQVGATLPNSWINCGGGGLGWSGGGALGIKLASDVQHGGPGKGKFVVQVVGDGTFLFSVPGSVYWIARRYGIPVLTIVLNNKGWNAPRRSMLLVHPNGDGSRATNEDLNISFAPTPDYSGIAKAAAGGELWAGRASTVAELAQKLPEAIQSVLNGKGAVLEAQLDGTAGKYVERSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKN2</accession>
    <name>A0A1Q5UKN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKN2"/>
    <dbReference type="OrthoDB" id="4240961at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="493" mass="55424" checksum="657E2EF04ED604BE" modified="2017-04-12" version="1">MISIIPETKPNIMIIGTGPHAQKTYVPHLQLLEARYGPMIQVLVDIEEKRDSVTEWAAKKCPGVHLHFVPMFTDLMPSRARAELDEIAVRFHINGIIIATEPLSHQVYALWGLDHGFHIMMDKPITTRVHAGTSVSEAKGIADDYQEILAAYQKLQKHKTTGFVVSSHRRFNPLIIRAHQYIREIVERTGCPVTSVSASYCDGTFRLPIEVIQQDYHTYKQGYGKVSHSGYHIIDMLCEFAKAGLVQSKRPDEVEVISSFILPRGFFKMMTQSDYQKIFGAEEYSKTCNFDEQGLLQRVVGYGELDATAQLTFRKEGDPVILAQISMSSNGYGLRSSLIPSKDQYKGSGRVKHESYEIKCGPFQSIYIESRSVKDSDEPCLPGDFQIGANNHFEMKVFRNFELTGHSGALEVLHLADLAETEGYDHTKLYTEQAKGKMILEFVQSIKGELLPSELTSNIDDHRLPVEIMSAMYLSHINHQASNGSPIVKVQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX6</accession>
    <name>A0A1Q5UKX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKX6"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="29225" checksum="B5FD98EEC80CC924" modified="2017-04-12" version="1">MAHSHSHSHDGGIGHSHDDPFNGHGHSHEILDGPGSYANREMPLIEGRDWKDRAFTVGIGGPVGSGKTALLLALCHALRDEYNIAAVTNDIFTREDAEFLTRHKALAPSRIRAIETGGCPHAAVREDISANLLALQTLQRQFKTDLLLIESGGDNLAANYSRELADFIIYVIDVAGGDKVPRKGGPGITGSDLLVVNKIDLAEAVGADLKVMERDAAKMREGGPTVFAVVKHGKGMDHIVNLVISAWKGSGAYEESLKRWKEGAPKGSGSVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULA0</accession>
    <name>A0A1Q5ULA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000149">
        <property type="protein sequence ID" value="OKP13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="613"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="105203" checksum="DB8AC67452423D5E" modified="2017-04-12" version="1">MQQKRRAWTRTIEKVKATHWKQFLDKAGEGKLWKAATYMKPRETWGCVPALHIDANEITQNEDKAQALLDAFFPEMNEPHEDPLSHLPLELPWQPITELEIQRSLKTAKGSTAPGEDGLPTLVWKHLWKSLKEIITGIFTASINLGYHPKRWRSAKIVVLRKPGKSDYSIPGAYRPISLLNTLGKLLEAVMARRLSYFAEKNGLLPDTQFGGRPGRTTEQALLVLASAIDRAWLKYKVVTLIAFDLKGAFNGVNKVSLDARLRAKGIPAIARRWIASFMSDRHASIGFDDFRTEVNPLANAGLAQGSPLSPILFAFFNSDLVDQPVTFRGGASAFIADYFRWRVGRSAEENVAKIQSEDIPRIEAWARRTGSCFAAEKTELIHLTRKRGEQHQGQVVMGGMIIEASPKAKLLGVTFDQELRWKEHVQQAIKRATKVTIALSGLRHLRPEQMRQIYQACVTPVVDYASTVWHNPLRDKTHLRHLNTVQRTALIRILSAFRTVATTTLEVEAYVLPTHLRLRQRAQNTIARLHTLPRSHPIWSALSRAQKRRNNVPSYARFPLAEALKTMDLERLDELETIDPRPLPPWRAESFTEIEVEPDRETARERAEAVRATSDLVIYSDASGRDGHLGAAVVALNDNLEVIESQQVQVGPMDRWSVHVAELIGIFQAISMVFKIAHDRPRPSGGTTTATILCDSKSALQATRNPGTKSGQRIIHAILQAATEVQAEGIALRLQWLPGHCENAGNDAADRLAKDAAHPGKAHPFRPLLTRKKALIQSRISAQWAHEWKSTPKGSHLRKIDNALPAIYTRKLYGSLPRNRAYLLTQLRTGHNWLSTYAKAHKFRDDDHWVCGAQETVTHVLVDCPILRELRRELRKEVGDAFSCISNLLGGSAEGRKGKPDTVSRSRTVNAVLDFAEASQRFRSRAPRGQPNNGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULI4</accession>
    <name>A0A1Q5ULI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-binding alcohol dehydrogenase domain-containing protein cipB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULI4"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="41016" checksum="27F8DCAC237C6131" modified="2017-04-12" version="1">MTTHLAAISLAKGEPFKLQPRPTPKPGPGELLIEVKSVALNPADCHMRDQGLFIPSYPTIIGFDFSGLVLDVGENVPVDEGMGPIFQPGITRVAAYSASVWKSCDPDYGVFQERCLVPWQQAMPLSNEGISWNQAATLPVAIQVPLSAWDMMGISRIGEATASSSCAFVTDTNGETQDHQSQKREALLIWGASSSVGTMGVQTARLLCDDPNSSFAAVYATAGAANQKYVATLGADCVFDYKDPSVVDSIVSAARKDGLVIRYCFLAMGQLALCQAVLKAFLGDGQGVEERNAKIGSAPIIPPDVEDVDGVETIFVMPSWEEGERLAQFQYWLGTWGRENLTNGTIRPSPEPRVVGKGLGAINGGLDVLFQGVSCAKLVVEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULU3</accession>
    <name>A0A1Q5ULU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_633</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULU3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULU3"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000014">
        <property type="entry name" value="Transport protein sec22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP13442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="215" mass="24990" checksum="6E008253BBB27E34" modified="2017-04-12" version="1">MVKSTQIARLDGLMLAASVDDEQAESELAEIKGQAKMIFRRLNRNSAPQASIESGQYNLHYTIQDDVCFLCICDRSYPRKLAFTYLADLASEFTTTYSQSQYLSPTLRPYAFVEFDTFIQRTRKLYQDSRASQNLDKLNDELRDVTKVMTKNIEDLLYRGDSLERMGELSGRLREDSKKYRKAAVRINWELLVKQYGPFAGVGFVVLILLWWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM07</accession>
    <name>A0A1Q5UM07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM07"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="22840" checksum="1A3C9AE8E8B76432" modified="2017-04-12" version="1">MTALVIQPVTINDVPALSELWYTAFSIPVNLRMFPDTPGVRAWWDEANRRDLLYNPLRKLFKIVDPTTPDFVVAYAKWDLDPSESGERFPPWHEESDHETCERLFTGLSEERKKLLGDRKHYYLDMLVTHPDYRRQGAASILIQWGCDLADQNGVAAYLDAHEDAAPLYRKFGFKDRDDLGVTSDGAIPMIREPQKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMM5</accession>
    <name>A0A1Q5UMM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMM5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="51280" checksum="36E6936322D2CF76" modified="2017-04-12" version="1">MYPGQLPGLKREESVRLHVNERRLPTPVNHLNTLRPQPPGPPSARALPFTMYRSEVSSGRLSLSATHGYLDYIQSPVSEPSTSWALPTGVQRLLGSTGSMSMSVSVSAPHHSLNSSQPFVSGSSALWATVVPFTHGSAAPVPQPTQGNHSHSAQPLGWGVSASRASDVSHSQGSSVPIPQRVFDYYHHTFPQRSLMSQARRAVKRKAQKLSSPANISHFQNTFRSSSIASGYASSLHDGGSDEHSSSLVGRTTSDTATFTTGSPSPEGELKIIMEDPQNGHLHREKRIRTQEELDDQKEGMRVLKDNGGACQACYKSKKRCGPGDPCPPCAARNRECIRSDRNDGETVSAGGQPTSASAPAQPLSTSSQFVSTSSQSSSSHTEPVSAPTPPPSPHIGFENLTSVQSSLIDRPSRPEDIPTEMTSNEDPPALGCDLLEDYLDPFLIDPWQDGMNCIDSAYDNVSYHWVGTGANGHLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMP9</accession>
    <name>A0A1Q5UMP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactose regulatory protein LAC9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMP9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="649" mass="73376" checksum="450B13334F04F41F" modified="2017-04-12" version="1">MFNTFVGIDHNDATRNPSGRRRAIVAKACVECRRRKTKCIGTQPCTGCLACNVECVFPEYRRRGRKSQKALSNAPNNGYESIVNLLFPHTPVHSLKGLSRSDLLDRAKILNIEDDHSPLTSNQSSSIASPDILKPVKARAVPDVEANDRLYKLQYRDSRPFEWDETSPGYHPSVEDDVNSLSLSTDRRSSFVGISSVAAAIRALTSILPTQFLDERSTVPSSLPGYTENPPPIISSTTSYRVISHRDEQRLIDAYFATIHIFVPIIHEPSFRTKYLTSSGSQDRSWLALLNMVLALGSVATSPGDSDEDFEYYHVAQQYLSLESFGNGRLETLQALVLMGGQYLHSRNRPNIASAIIGACYRIASGLGLHLRLPEGTEGKRGELSPNEPTIHAPLIHNIQLCRIINRIQDRLLINSLLDDSEIQFYDDMLLSWFETLPPFLRLPDPNVPDFQDARVVLKWRYQNIRFLLHRPLVLDTVIRKTPLHCLSTNEQAIVSRCRNIAAESILSIQEEWRPNKICCWNAMWFMFQACLVTLMALAIEPTDHPEYPNWCNQVQIGIVTCEEMSKFSPVGQKTKVCLEQMFMAAIKGSPPTFRYEHISTQPPLDTIMGIFANDWDHLNGDAIFSQFTTPASSYIDDQILHMQYQPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMY7</accession>
    <name>A0A1Q5UMY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acriflavine sensitivity control protein acr-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_431</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMY7"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="646" mass="71378" checksum="352F75092A7C054F" modified="2017-04-12" version="1">MTKGCYTCRRRRIICDNGLPTCRKCRDAGKECLGYQKPLVWVKGGVASRGKMMGRSFDDVKKPDGDTKAQSSTQSQVSAVANTAGFGFFSITESSSPTSSPSSGAHTSPESDTYVHETVETVTSGHADGHISLGLNATEEADSRMVHVPRGASMDFISAPWGLVDPLFKDMSQISRFYLFHYNQHMANDFVVYSQSKNPWRDIISLVGDSPLLAHGLCAMGALHYSLMSESDSTQMPWSSNSLLTSSSPLSPEDIETIVSPAGNRRPSSRAFQHFLEFKQRTLHQLSKDLSNPVMQKDDRTLAAIVVLALVDIFESGSGAWSYHIEGAKKLLRDRPENNLGRGILDGLETFAIDGCLIMEIMGSTLARPGALSKPFYSAAMGPAMLKRLEETSWVGCPAYLLEVIFFIHTLWYPDSEITTATPQPSALPASMQQGQPLSLESYLALLQGIRDFDPVAWAHHMQASHFLSDLSTRIALARSYQTAVYLYTSRVLSRTREGYTPPWADVGLPADHSAVASDLLNQICSVPYSDPHFKCLIWPTFIAGAECRRTSQRPLVLEKLGALYQAVTSVNVQNAAWVLRLMWQKHDQKRRENCVSTLSGLTLENVDGVGGAGNVDINDDDDEDYDNTFDWVDELDESRLDWLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNL0</accession>
    <name>A0A1Q5UNL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNL0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19428" checksum="30F4DC1ADB895188" modified="2017-04-12" version="1">MPKHSNFDEDRLQEACKANIAKIAREFGVSRTTLADRVKKAQSPFSITESRKNALTLYQEKALIAWIVKMCDWNLPPTAKLIEAWANQALARANAERQQVGKNSACYFILRLPKHLSLAPVKQNLKESKRIQAEDTGALSFWYDQLATLLKDVPARLVYNFDEYSFQPGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP79</accession>
    <name>A0A1Q5UP79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_45</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="334"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="648"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="615"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="723"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="753" mass="81740" checksum="9C1EEA14E8E6457A" modified="2017-04-12" version="1">MSAEAATNPPAAEAPVNGTPEATGAQEVAAAPETTAEAAAAAANNQPHSASLYVGELDPSVTEAMLYELFSSIGQVASIRVCRDAVTRRSLGYAYVNYNNTADGERALEDLNYTLIKGKPCRIMWSQRDPALRKTGQGNVFIKNLDNAIDNKALHDTFAAFGNILSCKVAQDEFGNSKGYGFVHYETAEAANNAIKHVNGMLLNDKKVFVGHHISKKDRQSKFEEMKANFTNIYVKNLDQEISDDEFRVMFEKFGEITSATLSHDQDGKSRGFGFVNYTTHESAQAAVDEMNEKDIKSQKLYVGRAQKKHEREEELRKQYEAARLEKASKYQGVNLYVKNLTDDVDDEKLRDLFAAYGTITSAKVMRDSLSDRTPSPDSEKEGETKEEGEKTEEKEDEKKEESEEQKDTEEDKEGEQEQETEKGEKKLLGKSKGFGFVCFSSPDEASKAVTEMNQRMVNGKPLYVALAQRKDVRRSQLEASIQARNTIRQQQAAAAAGMPQPYMQPAVFYPPGQQGFIPAAQRGGMPFPPQPGMVMAGIPGGRPGQYPGPFPGQQGGRGMGPNQQIPGNFQGMPMGMQVPGGMPNGMGYPMQGQFGRGAGGRGQVPGMPMGQGMRGGFRGPPGQMGRGQGRGQPAPAGQPGRDEAAPATGLSSQALTSAPPAQQKQMLGEALYPKIQAQQPELAGKITGMLLEMDNTELLGLLDDEEALRAKVDEALNVYDEYMKNKGPDGEPAGEAKPQEAAKEASSEETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPG4</accession>
    <name>A0A1Q5UPG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="243" mass="26493" checksum="2D08EA3C70740836" modified="2017-04-12" version="1">MRSIRLPFSNYDHDFDEYILTNSPGERWPRNSRAADSGLVNMLLMQPALMEAIDQKLDNESGPFYGFEFLQTWQDRYTDQAMVLVELNHSSSEASSTTSGGSFNGSHARSSTSGSSRSSDSGSSWDSGRVVPGGDRVQQALPLAVGVPEATRDRARARIPIPCRAAALPNLQRRMKRAMVEESGSAGALGMNRRRMGAITATRVRDFVIVATVITAHEQLAIRGGVGDLRTGALPMLSLFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ29</accession>
    <name>A0A1Q5UQ29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ29"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="61" mass="6974" checksum="C60F23B726616CF8" modified="2017-04-12" version="1">MHILPKYLEYYTSAQISNELGLTASLQSAQQPDDPFSTFSTLLDDLRGLKALDKNERYPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQA3</accession>
    <name>A0A1Q5UQA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQA3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="110" mass="12421" checksum="7D231EB4836B4E09" modified="2017-04-12" version="1">MRLFLDRVANKKSGSQLIESPTKPLFQLHPGPGSVHLGKVVDSYEGMPQNEPCSWCYVNLHRMKQSSPYSIFQSTLESPYLKARLEYIYSTSGVETGPTDVQDPQYVPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR48</accession>
    <name>A0A1Q5UR48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_4691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR48"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR48"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="65" mass="7490" checksum="94C3F583BF40BDD7" modified="2017-04-12" version="1">MAKSKNASQHHRSQKAHRNGIKKPKTNRYPSLNGVDPKFRRNHRHALHGTAKALKERKEGKREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URK3</accession>
    <name>A0A1Q5URK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URK3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URK3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP15111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="720" mass="81492" checksum="C3D919452578F52C" modified="2017-04-12" version="1">MAQFRDDSADTSRTPLDLPSGSLKPYSCVVCHRRKVKCDRKETCSNCAKANVECIYRPPPPPRRRKRERDGSRGASQEREKSVRRNSREASLGGNTWQHPSPARNLSNGAELNQSGSGRMIMREGNSVYLDKLVTLWPTHWKHLTNTDMHSTLWTSVSHELPDAAEVLGDAADDNSDNASQDEEDVSSMLLSHGTRESLAELHPDPLHIFKLWQTFLERVSPLTKIVHAPTVQQQILEAMSDLKQISKEFETLMFSIYCIALTSLQAGDVEKAFGESKKKLLSRCRRGAQQAFRNAAFLRTSNTVVLQAFILYLLSMRAFSDPHTIWSLSGIALRMAQRIGIHRDGSGYGLSIFETEMRRRIWFQLMILDATSAQACGVAAGSFVDTADTKPPMNANDSDLDPRMTEPACEKEGPSEMIFCLARSEFGKWLRRWNADTSGSGSPWAFLSSSKMSLSEKDKAIDELEDIMEQKFLRYCDQSIPLHFATTMMVRSASHYTRLMAHHPRQYHGSGTRIPQSEKDVIFGHCLKMAEYADYAQTNPDVQRFSWHMVNHMPWDAIIFMLSEMRNRTDPQEKDKVWEIIGSIYGRHIRQMGKRTQMPLHKALENLFVKAWRAYVDECNQHGRTPRPCPTVVSSLLSASNGSTETKIAEENVRMDANSTPIPEEQPGQDASNVPFATENESMDFLLGDSPMDWSEWDHLLNQFQESLVDDMTLMPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URL2</accession>
    <name>A0A1Q5URL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URL2"/>
    <dbReference type="OrthoDB" id="2096480at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="3"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP15110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="526" mass="59236" checksum="B7B0243B05F67FFF" modified="2017-04-12" version="1">MPETEVLIAGAGPSGLVLALWLHVQGVKIRIIDQAEGPAPNSRALAVHARILELYRQLDLADELIECGYQLPATNVWVNGSHRAHINLRQFGTELTPYPYLLTFPQDEHEHVLEKRLNSFGIFVERKKKLQKFVDNGSSITATLESANGDESTCEAAYIVGCDGAHSVVRHGIEAKYEGDTYVPLFYIADIVAEKYSSPLFNGEAHLTFVDETFNLILPYVEERHVRLIGTTIPKTAGNQQTDTSEPHHEVTFEDVLPEIKKTTKIEIQKVNWFSTYRSHHRVAEKFRSNRAFLVGDAAHIHSPVGGQGMNTGIMDAINLAWKLATAIKQPSMTEEAKNALLDTYEPERRSFALDVVGATDHGFTILTSPGFFPHILRAWVIPYLIPIVTRFQAVRSQIFRRGSQLVCSYRGNNMLNQTTQGSETVQPGDRLPWVTTEQSDNFSTLHDICWQIHVYGDSRTELEEWCKTKHIQLNIFEWNDKHGNNGFKKGAAYLLRPDQYIAGIFEGNDLGSQLDEYFSTRGLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URU6</accession>
    <name>A0A1Q5URU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000018">
        <property type="protein sequence ID" value="OKP15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URU6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="6905" checksum="295C4A602AAA6597" modified="2017-04-12" version="1">MCMSRQGVSKNVIMSTGLYNKVIQAALQNEVNVDQADFLDVFLRAVVDVTTGTALAEETGDKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNR3</accession>
    <name>A0A1Q5SNR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein YTP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNR3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886115" evidence="3">
        <location>
            <begin position="24"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="155"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO89649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="460" mass="50680" checksum="4BA5F335E62D818F" modified="2017-04-12" version="1">MTLLRQGSLWGLVLLAGLALAHGGHEAVPEGEAITLEPIDSTLWTHMILMGTAFGIIFPLGMVLGIVRSRWHVPVQIVGTIIAVLAYFLGHAHKGRQFGKNAHASFANWLMLLLVVQIVLGFYLKLHLEKGGQGRIRWIFVLAHGIVGKIIPVLSWTQMLFGGIAALGFCQGDHMGQCLAHFIMGSAFIGYGIVLTILLLVGQYWLRRTGRSQEFFDSLIIAAWGCVNTFTEHRWGGPWVHNDLQHTTMGIVWWCAGLLGMWLSRSRNGRPKRNLIPAIVIGLTGYAMSAHTQTLMISTMVHSIFGYTLMAAGLTRIIEISFVLRDKPNVSMSGANPNSFQYLTPFLLYASGFLFMGATEEQMQLLSQAVVNILLHIYAVHAWPEGAPEEEEESHKYANANGNGYMNGRTRSTADAQRISDAEAFELEGLMSDDEDEAGSSMRPKKTVDEEMGAKEAGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQV2</accession>
    <name>A0A1Q5SQV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQV2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQV2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14251" checksum="5890DD25D4A97DCF" modified="2017-04-12" version="1">MDPKMSDNSSNPTVQFIELIYGTPKDFATGFKISLQKILTDEEDLVAAVYHARWELNHSTNGIMHVPGAEGSGLLKKNVKKHIYADAVSPGFVIPGHADFIPKTAAVVHTRSLAFLQMHLGEIFDLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRI8</accession>
    <name>A0A1Q5SRI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA cross-link repair protein pso2/snm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13289</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRI8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRI8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="691"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="849" mass="93476" checksum="7A5B531FC93ABC2F" modified="2017-04-12" version="1">MAGSFAKKASTPSKGPASATKSSSAKGNRSILNFFQKTDAPAGATSRQPRITQFVGSSRSPITGRSTPKLQHGNSLKSDTSEGLFLEDKKGLAKVERERTAVTIDLTERARSRTPEDIWGESEDFLDPEGSRYSENGQSVKRRKVESPDASNDDEEANDPPMPVKPAPAKKSNSGPFIDESDSEDDMEAYREQEETSHTIDTTNTDQRPSLDDESSTKPLAAQRPLAPLVRDATNDANDDELANFDDIEDGDELVGEEFRDGPWDDQEDEEGQNTDFGMMPNGLNDSTYFDAEPEGVSTCPICQRALAGFSETELSVHVNDCLDGKSSDSPATSTIDSVPIVPASDTKKEETSGKGLTRFERAAIARPPQGDPYSKNTPGTRSAFSKMMAGNAEDTAWAAAAANEVSSRGKQAYQRTCPFYKIMPGFSICVDAFRYGAVEGCNAYFLSHFHSDHYIGLTKSWCHGPIYCSRPTGNLVRQQLRVDPKWIVDIDFETTTEVPDTGGVQVTMLHANHCPGSSLFLFEKSFGSGPKARRQRILHCGDFRASPTHVQHPLLRPDPINPVTGQPRQQRIDTCYLDTTYLNPKYAFPSQEDVITACSELCVRLNEESGVGSELGKTNGGSLMNKFFSSITKSDSASEQSSSNGGRLLVVIGTYSIGKERICMGIARALGSKIFANPQKQRICACLEDPELSALLTTDPWEAQVHMQTLFEIRADTLADYLDTLKPHFSRVVGFRPTGWSYRPPAGRMLDNPPVPTVLRGEHWRTPFTAQHLIPQRGSTRESACFGVPYSEHSSFRELTMFCCALRIGRVIPTVNVGSQKSRDQMKAWIERWEGEKKRNGLFPAAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK4</accession>
    <name>A0A1Q5SRK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="53376" checksum="4D08C67A14C0E986" modified="2017-04-12" version="1">MVGFASAGSRFSTTVREENAWAFQSLTLILAGSRALLAIQYTVNVFFLRSSMKHAARGVAYTALVFWVTTVFYIVMYLAFSGSYGFRARIWTVWFVLFGVEMWTVTGLSLMYPDLGFKDTHLNTRMGLLTLIIIGEGVIAITRIVNKTVRPGGWTKWSFVHILGVTTNVVYFDVSPRGQLRKFKQQLWAQLHFPFHVVLILLLEGSQILALTLDVTLKLKYLGETLLFVCEPPRPSTDRAVALIRSTIDDMEIPFSKGASQEWASISSLLESLALQPLCPNRETLDYEYTADLFNDLTGNVTAALFSSMDILPGKKADINLLTNQQLLEMYMKLLAFVYIYFFVVASISMGLLAAFQVLCRRHEIHFHRNISTTVRIVLATSLASLVSFASHFPLAYSFMTSPIILYAFTLTLLCGQFHSPCLLFDMKSDWLKCSWLTDFWTISHPGEMQRADGTGEAAPNLSVVHLHRGWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ22</accession>
    <name>A0A1Q5SZ22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ22"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="160" mass="18323" checksum="42116DF981EC4373" modified="2017-04-12" version="1">MELVQEIIKGTNCPFLPFRVTDMIGIAPKNQHPELVAEKPIHLSNPLDNDSGRHKNERSMIWYQLLFILLALHIAQDHSPGRKVLLDEVLPNTAFQQALPLLGIYWLWGLNNIGIDASSTYILGEHSDGFFSREGALRILQREYDQVPLVLRWCSRRALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZA2</accession>
    <name>A0A1Q5SZA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZA2"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22587" checksum="BFB86D25FF07F209" modified="2017-04-12" version="1">MPPIRTRDGEKKPSESRAEPAFKKRKGFSVGPANLPDGTYRRKTQKIKSDLIQKAKVKKAYAKIKAQELATNTSKPIFTTAEEENTEDKPEPASLELHPDRIAMMNEPEPAPEPAPRPERRPRDRRERRPKPSAFSKEIEVAEKRKQAAEARQRAIEAKQKDREAMTRAKRPDQFGKRRLGRESNVLLSRVQRMVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZE7</accession>
    <name>A0A1Q5SZE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZE7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012931296" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="7788" checksum="7FDA663C117CC37F" modified="2017-04-12" version="1">MKWSHLTIIGLVAIGNTQPLTNPYSKWSQAASIQGLVVDLGYGRFGGKQDSSLNAWLGYCGIYSSRLVSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZL2</accession>
    <name>A0A1Q5SZL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZL2"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="650" mass="72619" checksum="A3DCA58CFAEDE67E" modified="2017-04-12" version="1">MDSPTRPILSPTKILLPVSPERMNQQTIPASPSLPTDLLSLHYKNTKGVSEVQAKVAFLNSLSRGGSPVTHTQSAAHNAALQRAILGREEAESALATVQEELSEAQSRERRISERLESLLEELHAAKERQAHERSIFEKEIRKARKEAFRAGSTLVKLQEELKHSKSESKALKDEVAAERESKDKARQEAFERAYALAGLTEELEMLKGKLRSMEAANKTKKEMQRENFGRVSLVEGDLAFLATPRRPKRAAVGSVKSPVSEIEADEVVEATPPKRQRLSECTTTADTEETASDISPSDANLEVLEEMRDELEQERRRRTEAEDMVHFLNIECQFQRCSCRIAESQGRRYIYDTEYYETFQKPQIEAKAEAEAEAARHAHSRQSQMQQNQLEQMAPHPQSSHTPSVEPPTHVHHQPAPQSEPVSGPEPVVKPEPVDLPEKMQMPEEPLVTFSPETGTFRTFPSPLRDNVLPRRTDSFPIPDMPSLKPSVKSWRDSAASSNYAPDTFSPSEEPRTSRASAENILSEGANARLSVESRPSRRTERDPYKPTVSTTKRVPLREKAGTRTSGSSGLVPDTPINREDALAQIAARRDRARSKQRSVSANEATGCSGSTATGRGPRRMPNLRADGKPENDLAERRDLSAPVRMYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZT5</accession>
    <name>A0A1Q5SZT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor iws1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZT5"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="427" mass="48428" checksum="C6A7842BD883E67A" modified="2017-04-12" version="1">MSASPEHQAGSAAASPEPEKVATPIAADDDEAEQPADPIAEAGDNDDDDNEGGISDDESILSEVDEAQFEDFNPENVDVEDRPQLAIDEENLKLIGRHKRKRADDGEGRSRRKEGRREKKSRRAQDEDEGEDGSRRKERKKKEASPDTDEETLDPETRRRRALDRAMDEAIRKPGKRRSRKQDGIDLEAMADAEIEDMRKRMTHAAQMDAISRQEGKPAMHKLKLLPEVIMLLNRNQYINSLVDPEINLLEAVRFFLEPLDDGSMPAYNIQRDLLTALAKLPIQKDALIASGIGKVVVFYTKSKRTERRIKDMAEKLLAEWTRPILQRSDDYSKRVFQQADFDPTKIIKRTQTPAEIVAAEARAREKLPPRLANRARVDRTNVTYTIVPRQTAVQESKFARPLGSSGEDRFRKMQARNNAAQKGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0W7</accession>
    <name>A0A1Q5T0W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transcriptional regulator CRZ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0W7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0W7"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="696"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO93921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="761" mass="81762" checksum="E4DE6F5CEB90FF11" modified="2017-04-12" version="1">MASHDHTQGTGSVSADIKHRSVSPSPHAQQQYHDPTVGLALDPSMSAAYGTNPQFDTSNADPSISGTESYGYPANYHFSGAAQAQGLVPPSTQPFPPMLNTTNIGMSQSFNPNMANQLDPGVSSLQTGQLTENFSNLLNSNTGDLDFSAYQSHSPNSASASEYDSSLLLDPQMHQRQQAMHQAVNPADLVSPISNPSASSHHSSQDPQQSSPGPMSPPGGTPGAFYTPRHSRHTSLDPAAAAYLSAQVNPDWQSMMNNNSAFQTHRRAPSEVSEVSSANHSPYLSQHEYEGIENNASPSLVPQNDPALYENALGIEQFTLSDQHQQGFSPAHSPYISPRLMPQQTNDMVPSIQYTSTSNQFPPAPTEMYGMPGDDMMGSIPAGDIGQASQMAPPSINVEFAPPSRSPSFGPPKPVANFDSLSPPAMRSRVRSKSDPYAHPASRQRSPATSTTSLEAIAATSPRSLSPHSRSNPGSRDASPSRSNRRLSTSSIESRNYILDLADPGRPGAAPGDSKRVQKHPATFQCNLCPKRFTRAYNLRSHLRTHTDERPFVCTVCGKAFARQHDRKRHEGLHSGEKKFVCRGDLSRGSHWGCGRRFARADALGRHFRSEAGRVCIKPLLDEESQERDRVLAEQQQHQQQPAGHLQPVPQPLVMPGVPGMDGQSSGNFVLPAALLAQYPALQTLQWDQLAAAGDDPSDIGGRSSFDASSGGEFGFDDDESGISSVSGISGGYGNNQGTMYGGQMLGMNPGDPGYVDQKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Z1</accession>
    <name>A0A1Q5T0Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Z1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0Z1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13366" checksum="FC38EA904674AC65" modified="2017-04-12" version="1">MSENKTVLICQPFDFIHGRELEGAIRNHDTLFQQAFQYLNPNGWFEMSTIEVNTYSDDDTHLKATNMLESVTQLHAGSKMFGKEMASVFTWKEKMEKAGFINVREEIFKVTVPDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1G1</accession>
    <name>A0A1Q5T1G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1G1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1G1"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01443">
        <property type="entry name" value="Cdc25_Acr2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF50">
        <property type="entry name" value="REDUCTASE (ARC2), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="153" mass="16959" checksum="EFDE87A1B2D25CC0" modified="2017-04-12" version="1">MAENTPKEVPWHAAYPNPKSVVASLPRHELLEWFRDGKKAGKDFVLVDVRRTDFEGGTIRGSINLPAHSLYPTLPAVYALLSSSGVKHVIWYCGSCNGRGPRTASWFADYLAQEQDTTMQSLILEGGIKGWAAAGPEYTELMDVYDASVWTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T282</accession>
    <name>A0A1Q5T282_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T282"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T282"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="9861" checksum="B53206D2C96E2A10" modified="2017-04-12" version="1">MTHPIHLAVFKNAARPAHWAIFVPTDKDGKVGNLIHVTGNPATGFFLDLSASTTSARPPASTTSSPSPKSMSVSLLPKPRMYHRDATLSPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2B9</accession>
    <name>A0A1Q5T2B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA cleavage and polyadenylation specificity factor complex subunit pta1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2B9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2B9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO94380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="766" mass="84781" checksum="139A14851400D294" modified="2017-04-12" version="1">MAQSTDHVVDQVAQLNAARSLVLGDAALYPQIVNGILPIVGANARLELRRWGADFLAETFASPMLATVQKQELAPTVLQSIQETLALPETDTAVLSSLVQTSASLYPLIFRHIVNHPEDSKTWETMNAVKQEILRKMDSFPCPAKICSVKFLQRVVQVQTPGLIADPRRPDQNETSLAVVPRNHALLAIPLLEAEASGLLDRLLGVFQEETSDPLVVNATLNCLAPLIRTRQSIANKIIQTILDFFPAKHVRPPFTPTVRVGVKSMERTARALLFNVMKKYNKSPATIRGLDQRLTNPFRNPSNPLMGKMQAYIERLMQSRLEVTEDASRKRGLPVEPTDGLDNAKRARLDAMTPPLLKIPPLPPGPTSYDQLFTLTQDIGLSSFDVKQLPPDLVVKIAVPLLAQVNPSMLTQAVDAIRNRYETITKEQNLKRQQLYQAATAAAADEDDDYEPDYEPLDVGADASEEAIALAAEDAELEPDLVSLGPFVLPQPPPLTEEEAGDVGRSAVSRVFGMIDAVETTPSPAQSKTQQQLSFARLAGSTFDRDAWVILLTRLATRAPAGLEGGDKSKGELATGKRQPTISDSIRETLYRYILEDFRARLKIGITWLNEEWYNDRVRMKAANSDRGDEDEEPTVALFYDTWVLRLLDGFLPYLDSRDIKVLVRFLSEIPEVTIAITQRVASLAKDPERVNLTVQALMYLIMFRPPAREMCLNTLEDVYQTYEESRPAAGKVLARWRPQALPAPTETAPAAPQAEVQAPPTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2C9</accession>
    <name>A0A1Q5T2C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Minor extracellular protease vpr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_11671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2C9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2C9"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012231447" evidence="11">
        <location>
            <begin position="21"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="157"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="13">
        <location>
            <begin position="607"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO94404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="877" mass="92646" checksum="438AC6EC8C7BA148" modified="2017-04-12" version="1">MAPVWPWLGALLAALPVALAGHGDPIAQKYIVEFVDSTTSSASFLSTLKDHGIPANLNHDLSFALFHGGSFTLLDDNQNEAAVVKQISSWPIVKKVSPVRELEQPRREVSSVAHGAPLRRSVHSHSIRRRDTAGHEGNDYPHIMAGVDKLRQEGYLGTGIRVAVVDSGIDYKHPALGGCFGKGCLVEFGFNFLTNTSDPWEGHEGHGTHVSGLIAAQPNPYNFTGVAPNVTLGHYKVIGKQVVKTGTDIVSAAFKMAYEDKADIISASFGTYKGWSDEPWGQLIQKLAEAGIPSFVATGNDGSFGLFLASNGIDNSAGIGIGSVNNVYSPLLLTGASYSTRNTTKQFGWQIAGTSDFKNGTYALYPSSLNSSVVGDSCQPWTGNHPNLTDKIVLIRYGGCRGSMQQTNAVNAGAKNILFYLNEPGTYELPVSNPALTGLGMVSAQTGEKFVKLAASGANVTLHMISKAYAKTIFINETNPQSGGQISEFTQWGPSNELLPVTAASGVGGFMLSTWPVAEGAYAIDSGTSMATPFVAGCIALLMEARGKNKVTPAEIKSLLSTTSNPNVFHDGVTASPFLGSVAQQGGGLIDAYKLVHTTTKFNVSTISFNDTEHIAPAYIQINNTGSSPRVYTVGHVSAATVYTLPDNSSIPQRNKLGNFVDRTTVGASLKFSSSSVLVAAGGSAVLKVTATLPKGLVSRRIPVYSGYITLNGTSSDDSFSVPYLGVATAMRNVTILDTTAGSNILVDSETNERVQANQQFVLPKQDGTLSQVKTSYPIFQTKLSMGTDLLLVGVKAANSSAILPLADPQTALPRTVEGATGPTATSFTGLLANGSYVPAGNYSIVVRALKIFGNRSNPRDYDTVKTVNFGITYASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2T0</accession>
    <name>A0A1Q5T2T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 2U1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2T0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2T0"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="445" mass="50080" checksum="F190057D56E1BE73" modified="2017-04-12" version="1">MGELYWDNAGILVQPYGKEWQIRRRMLHQALNPSALKLYKPVQEAEAARLCRALLDQPKSYEGLIDRFTASVVFSIAYGHRIDSMSSEVIRQRLEFMQYSASLNVPGRYLAESIPWLKYVPDFLAPWKAEIQRKGREEAATNVALLRRVQDELHNAKRPSDVPDSLSKLLLEAREADPATFGVLSERDFSFVPASLFGAGSDTTASTLCSAILMLVTNPQVQAGAHAELDHIVGMTRLPTFDDEDNLLYLKALCNEILRIRPVAVLGGTPHANSVADTYKGYYIPQGTTILSNSWAINLNPTYYPNPHHFNPLRFLGIRPESLSYLSKSSPEDLAEMSPPRPHPAKEGHSSFGWGRRICPGAGLAHNSLFISLARLLWAFEFRPAREANGAERRYDTFAYTQGFNIRPQPFECEISVRSETHRQVLMAEGISAEKVMNRFPPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2U3</accession>
    <name>A0A1Q5T2U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2U3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8631" checksum="1468744EE94854CD" modified="2017-04-12" version="1">MYFDAAYGKEYHDSLGDIWGPFLVERLGICRARQEYIRASDLKAWSFWSDLYGVIKSKTTSADDLVSTRHLASHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Z8</accession>
    <name>A0A1Q5T2Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Z8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Z8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="27500" checksum="67649ABC6CE02CC5" modified="2017-04-12" version="1">MRSSQRKYRSPAVSRHPPITPGASGSKTRNAAREPSRSSAAPRSSFPRPSSSSSRQMRTTYQTTDTPNEAEQYDCDEDDLGHVIAAIDMKDYGTVGCAYYSAEDEKLYLLGDSRSGGMEAIDAYTLSYLPYQVDVRPTQEFSFSNAQNSLVALDMSSSHEERIRFFVPSTGIDGPEEISAEDMGFSLSEGRLLHISSSVDMENPVSIGCAGAVLTHLQRRRATETSIGPMDDCPFKVRYLEMFSLRDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T407</accession>
    <name>A0A1Q5T407_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T407"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T407"/>
    <dbReference type="OrthoDB" id="427213at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000036">
        <property type="entry name" value="Putative sulfate transporter YPR003C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="630"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="768" mass="84200" checksum="076367F7DC7BC857" modified="2017-04-12" version="1">MSESSPLLREDSEGHRSLQSRIVNIFRTPGNRTASPGPNSSDDGRGTPGLGITTTSEPDARTRLLESYHQADPICGERRCSHGTFSPRPEDAERHGYSVPSSVHFGYNGDEETGATPSHSHGGEDHPGSRPDSEYTSQMKSSLSALSMNEDKKLYISYYIPFFNWISQYRWSFLRGDLVAALTISSIYIPMALSLASNLAHAPPVNGLYSFVIHPFVYAILGSCPLLVVGPEAAGSLLTGAIVKSSMPSGSSKDDDLMESAIIIGISTAMAGTMILVAGITRLGFLDNVLSRPFLRGFITAIGFVIFVDQLIPELGLAGLAKDAGASHGTTVEKLTFIIRNAGSSHGLTAIVSLVSFSIIMFFRTLKKWMMPHFPQVIYFPDRFIIVVLSAVLAYTLNWEDKGLELLGNTEITSSQLFAFNWPFRFSHMKHIRTAMSKAFIITLLGFFESSVAAKGLGDSKPDGIQGMHMSANREMVALGVANLLGGCFMSLPAFGGYGRSKVNAQTGARTPMSSIFLSLITLVAILVLLPYLSYLPKAVLSSMISVVAYTLVEECPHDVIFFLRLRGWTELVLMLLIFTTTIFYSLELGMAMGIGLSVIILIRHATQPRIQILGKVPGTNTRFENAELQRENVELIEGALIVKIPEPLTFANTGDLKNRLRRLELYGSSRTHPSRPRMRPAEYNKNIIFDVHGVTSIDGSGTQVLYEIVQAYVETGVRVFFCRVPNANVFRMFERSGIVEQCGGLTHFVPHVDEALRLAETEEQSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T609</accession>
    <name>A0A1Q5T609_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sterol 3-beta-glucosyltransferase UGT80B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T609"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T609"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="5">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="6">
        <location>
            <begin position="393"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="808" mass="87895" checksum="AA12190EFA57880D" modified="2017-04-12" version="1">MGKSPCPEREPGAPQTPPPYAPYLDPQLTAESGDAHTDGRIDVRLDSKLAKSLAQIANQQQEDLHHAPPRAQPEEPIGCDVKLNIIIQIVGSRGDVQPFIALGNALQSHGHRVRIATHNVFENFVKESYLEFFPIGGDPAQLMAYMVKNPGLIPQIKTLRDGEIKKKQVMVAEMLTGCWRSCIEDDPVTQEPFVADAIIANPPSFAHIHCAQALGIPVHLMFTMPWSSTKAFPHPLANLQNGSMETPGTANWVSYGVVEWLTWQGLGDVINRFRSSIDLAPVPRTEGPCLAEALEIPMTYCWSPALVPKPRDWPDHIDVCGFFFSDPPDYTPPPDLAEFLQSGPPPVYIGFGSIVVEDPQKLIDTVLAAVSRAGVRAIVSKGWSELAGPADYNVYYIGDCPHGWLFQHVSAVVHHGGAGTTACGLLNGRPTTIVPFFGDQPFWGDMVAKAGAGPEPIPHAMLDPQNLAEAIQFCLTPEAEAAAQEIALKMKTESGVVTAVNSFHRNLPLKRMRCSVIPGQPAAWAYTRKKQSLTLSKAAMNVLIEYKRIDTNQVKCYAINPIIIENRRWDPLTGVLSAATSTGTNMLQSTGEMFYNPYKEFKKSRTGNLSETDSSGSTPSVNRSNSDPFQTAANMAGATLQGFGKFSATYFRGMIVDIPHAAAEGFRRAPQLYGEKPKEYGNVHDWKSGAIVGGKNFVGGMTTGITGMIKHPIKGFIEEGREGAMKGLARGALGMATNMPSAGIGLMAYPFHGISKSIEAAFRTKTPKEIVSARLREGFALTERIQLSKEEKEEVVQVFDVLLSSLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T701</accession>
    <name>A0A1Q5T701_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T701"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="101"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="256" mass="29263" checksum="BC006046F68B6915" modified="2017-04-12" version="1">MSPAKPLRLGLVKEGMQLKIPAPKKDAYYFVSYSSHKTLLGLAVTTLAGAFANDPVNSWFRPLTSTAEKNGPAVRRFYSRYIQWHKVSGVVLESQPPYKKSHILGETEGDDFPAAVIFLTPPKSKQRWTIVGLWRTLKLYIDELWHPMDLQLPESVGIHRLLKENPEAWHLEMVAVHPSLQGKGIGKLAMKAVFDYVDQAPILIECSSEKNLPFYRSLNFTTLEEVEMVDAPQFDGDTGRVKQWLMIREFKCYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8L3</accession>
    <name>A0A1Q5T8L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8L3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8L3"/>
    <dbReference type="OrthoDB" id="3490397at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012999411" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="14661" checksum="3C7B3CD1F4B7BEE1" modified="2017-04-12" version="1">MQLTSFLPVILSTLSLTSALPNGQASTWTATNFQLQCSPGGCAYRFNITAPASENAPGFSTYCEGLTPNATACANNTITAAVSPLTNPTWNVKVQHEWHVIEEDYNSEATYWQAGSANVTETTTGFSIKPDVFYGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8N8</accession>
    <name>A0A1Q5T8N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10761</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8N8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8N8"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF13">
        <property type="entry name" value="PHOSPHATE TRANSPORTER PIC2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="214"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO96586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="307" mass="33943" checksum="1DD1056BF8D04423" modified="2017-04-12" version="1">MAMQERKLPFGKIEPNSGKYFVSCALGGIIACGPTHTAVTPLDLVKCRRQVDPKIYTSNISAWRSIFAKEGLRGVFFGWSPTFLGYSFQGAGKYGLYEYFKHLYGDNLFPQSNRTLVFLGASASAEFFADMALCPLEAIKVRMQTTLPPYANNLREGFSRVVAKEGIAGLYRGLYPLWARQIPYTMTKFATFEETVNQIYRYLGKPKESYGQLTQTGVSFLGGYIAGIFCAVVSHPADVMVSKLNADRKPGEGAMKAVSRIYGNIGFSGLWNGLPVRIVMLGTLTGFQWLIYDSFKVFLGLPTTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V8</accession>
    <name>A0A1Q5T8V8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V8"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="27"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="457" mass="49589" checksum="ED11C69AEF417A14" modified="2017-04-12" version="1">MEDRSFEPMLVAGNCQVNLWERLQPFLVLASSTALVFTGCGINFTFGVYQELYDSMSRIPNTPFTGASPAQIDLIGTLSIALMTIGAPFTTAWTKQYSPRAVIWSGGIIYAAALVLASFSQALWQFILTQGLLLGIGTCMAYMPSVTVAPTWFSRHRGLAMGVILSGTGIGGVVWPLAFRSLIERVGFRNTLRITAGISFVLIMTAGFFMKWPASQLSRIQTENTANSRRLNFLRIPLIDWRVVRTRKFAAHALGAALQSAAYYTPVFFFASFARTLGYSQATSANFIAISNAANALGKIVIGYAADRMGRLNTLFLSTLVSAIAVLALWLPSALSTTAASGSMLFIVFTIFYGIFASAYVSLFPTSLVELFGIQNFVSVNGALYMVRGLATLLGTPVAGLLIRSNQQQKASPRSYENTSIMVGVLLAAATFAVLWVRIEATVTLEGGQGHRRKWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9Q6</accession>
    <name>A0A1Q5T9Q6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9Q6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="5695" checksum="D257A2CE10169DE0" modified="2017-04-12" version="1">MLFLLESELAHVSGKYVKAKPFGNEVIVSRSAGSSTLITTGQNRASVTGVAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB11</accession>
    <name>A0A1Q5TB11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10182</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB11"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB11"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="131" mass="14155" checksum="CF794D659A7E90BC" modified="2017-04-12" version="1">MSTSNIETSLRAIIGNTESASGPSTSRSLPAPTAATLLLRPASVRIFPFPSDDNRGCGGMQNISVKDTTLISRSSAYTEFSYTTVNWSEKAKRRKTTGSGRLRSLRDVHRRFTNGFQTGTPKGARGPQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB52</accession>
    <name>A0A1Q5TB52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB52"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB52"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="165"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="32603" checksum="8F64A6DAF30F7C4E" modified="2017-04-12" version="1">MADAEVEQKQRKSVAFSEGDVIMDTNGQVTDAPAAEKPADNEVDEMTDMFKGLSKKKKTKKSSKETGDAEEPTADGEFDVSALKKKKKKVKKDAGDFEAKLAEAGIDEEGGDKEQAEESLPEGDAEAGTGIWAHDATQVIPYPLLVSRFFTLVQSHHPDLLSSGTKAYKIPPPQCLREGNRRTVFANIAEICARMKRSDEHVTQFLFAELGTSGSVDGSKRLVIKGRFQGKQLESVLRKYIVEYVTCKTCRSPNTELNKGENRLYFITCNSCGSRRSVAAIKTGFRSQVGRRKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCF9</accession>
    <name>A0A1Q5TCF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacterial alpha-L-rhamnosidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCF9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="61" mass="6529" checksum="7BB0B95AD24B4633" modified="2017-04-12" version="1">MPKSMTLDVTGHLHEGSNVLAAEIGEGWYAGRFGLFGGRRNIYGTLGLICELVITYASGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD06</accession>
    <name>A0A1Q5TD06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2-heptyl-3-hydroxy-4(1H)-quinolone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9533</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000680">
        <property type="protein sequence ID" value="OKO98097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD06"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="440" mass="49428" checksum="2F3C6619E45FE722" modified="2017-04-12" version="1">MRPCKVVISGGGVTGLTLALMLEKVGVDYILLEAQADILCSDAGTGICMLPNGLRILDQLGCYESLLDQAGDAIDSVTVKGPDGEVLRHTTGWQQFALERYGYKAFWCDRSTLLQAIYNQIRDKSKLRIRKSVESIEHLESEVKVKTSDGEVYHGDVVVGADGIHSRVRQEMARHAREIGAGEQFSEEKDVPSTYCCLFGISSTVKGISQGALDYVLNHGFSYIVGSGPKDRTYWALMKKLRRTCHGTEIPHFLPEDSDTILQEHQNDPVGPGVFVSDLREKLLRPTVLKPMREFTYQKWFLQRMLIIGDAAHQMTIIIAQGGNQAIESAAALTNCLVSALSGKQQAGPLSCHEIETLFENVQHTRFARVKGMIERSHQRQLMDSLETQKWKDYMLHEFPSSLPRAMKERWDETFAPAISLDDLEVPVRQKTFRWLDEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDD8</accession>
    <name>A0A1Q5TDD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDD8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="16743" checksum="331F6C406ED4B724" modified="2017-04-12" version="1">MDETLREYCIGKIAHVCECLVAWKGDSIAGVDGNQLLEPYLIKPSNSDSNDDKRAFADVLSPKQLLKNCTEMSMDVSTFVFYHCDLGPTNILVDVSTGSLGIIDWEIAGYVPVEWVRTKFRLSSGMYFWACTLGMRILGGIGGVQFRHILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE21</accession>
    <name>A0A1Q5TE21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspergillopepsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE21"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE21"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012615005" evidence="2">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="276" mass="28851" checksum="75DA8899C01105BD" modified="2017-04-12" version="1">MKFSSAILSTTLLATAAFAAPLTAKRQARYEARRLARAESGVTERHGNPAFKPDTQDLLHLNGTTHEDYSSNWAGAVLIGSGYTAVTGQFTVPTPKVPSGSSSSGTYSASAWVGIDGDTWGDAILQTGVDFTITNGKVSYDAWYEWYPDYAYDFTGIAISAGDVIKVTVTAASKSSGTAVIENVTTGKSVSHTFSSSSTQGSLGEVNAEWIVEDFESGGSLVNFANFGTVTFTGAQATDNGSKVGPSGATLIDIKQNNQVLTSSSVTSNSVKVSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEA5</accession>
    <name>A0A1Q5TEA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEA5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEA5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012321368" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="12850" checksum="1087531028F35AD0" modified="2017-04-12" version="1">MRLSAFPLAGLLFLGSLATATTDPLNYRNIPGYVASNTSTATAALGLIKSRPELSILAEKIAQLGGFTQAFDTNPNWKFTFFAPNNDAFESYTGAYFDTFETAPYVGREPAESEVALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG23</accession>
    <name>A0A1Q5TG23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="9329" checksum="D344F5B7956C985C" modified="2017-04-12" version="1">MTSPRNSLFTELQRRQVSRVTTMAASTSRPLEYLESLPGMTFNKLYQQPSTALAIFRRMLPDLDPLPTQDLELWVKAESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG66</accession>
    <name>A0A1Q5TG66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Branched-chain-amino-acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG66"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37390" checksum="580963937342E06B" modified="2017-04-12" version="1">MTSMGKVFTGYATRTALLKRSSNPFSKGIAWVEGQLIPLSQARIPLIDQGFLHSDLTYDVPAIWDGRFFRLDDHLSRLEASCHKLRMRLPLPKDQINRILDEMAAKSGIKDGFVSLIVTRGLTGVRGATPEQLLKNNLYMFIQPYIWVMQPDVQRTGGSAIVARTVRRTPVGSMDPTVKNLQWGDLTRGLLEASDRGAMYPFLTDGDGNLTEGSGFNIVLVKDGVLFTPQRGVLEGVTRKSVLEIARANGIDARVEFVPVEMVYHCDEILMCTTAGGIMPVTSLDGKPVKDGRIGPITKRIWDEYWAMHYDSRYSYALNYGDSEEQSSGTPRAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG81</accession>
    <name>A0A1Q5TG81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG81"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="576" mass="62532" checksum="E826E34718D40574" modified="2017-04-12" version="1">MRLDAAVDDLERWWSGTQVDSQGKYKIPDYQNGHAYLTSHRVCYVAAEEPRKFSVGIDLKEIDRAEYQKGKNDKSRSATASPAVSQQTSLLSVHPSSPRPQSVGPQQSSSPKPVNATWICPICSFSNPVPSNFDPATATAATHLPPCLACGIKPPFTTVLKAAISAATSRDPPLPNTATLPTENDNTHKNGSLSGPSGLAGSVSCPRCTFVNHPSLMECEICGAPLKVGGPSIQGDDTSRVDSPAPFFAQSRITNSEVTDSIKLSFREGGEKTFHERLKGALIQRKWLLQNAPPVPPPSQAGALPSGPAIAEPQPATPRATAVGIAGLEQRGLETRMNNQLVIGNAFEDLEALMASAKQIVALAETLARESGMTTNGGASAETNAVLSESAAALGMVTTKDMLSSGSENLYLSELSRDLAEYLTDDRKGVLQREGGIMSLIDLWAVFNRSRNGVELISPSDFQRAAELWEKLKLPVRLRRFKSGLLVVQRYDWSDEKTVRQLQEWMEELRCVPPDEAVPWDWTAFGRAVTAQEAAQRFKWSVGVAAEELEMAEDRGILCREEGIEGLRFWSNYLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG89</accession>
    <name>A0A1Q5TG89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG89"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="917" mass="105810" checksum="6155053ACD7A7377" modified="2017-04-12" version="1">MPFTAKERQKVEKLRRRYRIDFLGEVPRHEWPESHRSTFNAVEELGRKQFDTYAVDLTTVETAPWSADVKKQAEDLTERAKRCVRRNESTWRFACEPYALARLTSEVVWIEAVGLNRIFSHREDEPVHHESSIEKELPRATKPDAIYGLRQTRNIENLLNDKACPGTPEDEQDKLVHEILGESPLSEEGDPILFPFLVLEAKSGKAAESDWISIQLQSAFPVRTLLCTQTRLKEIAESFLNQNYQKPSPLVWLVMNRGEDWRVCAACIKHDAGRKSGTVGSAEYQIFDLWGGSITSKNGALQLLLIVDYVFEWARDIYREDILSELRSIASGQNDSASMVHPDTDIFSTLTSMHLSVPHEDDRLIQDSYDQGMNAFKAMDSQHGVVRHATFIESHYRCFFVTRDNVATMLQSTDQPATQTLARQIITQLHEIPLLISWACLNMMEEQWTGRTRMPRFYHLDETKFYASVTYSSFLMPDWVQVRELVVIAVAQDAFECLATAAKYSRISASMPPPVEQGCDMEVVKDLVTKLRAGNARHTLLAAIKRKCLRFAGEGSSVYLVPSNGVSRDIVHYLYNYFKKGRMPPQEPFMNISTSSDQTNLATSSKEPFDFGGLNVSEDGCVLVYATGHNHDPGRRKMSSICIFFTDGPPDLPTTERLGTVIKHTYENYDVYHTSRIHRAPNYRELGKKKKEEGNRWNIRNSYGVFSEGFHFLHWLAVLECPLPVRQGSPRDGVLWAPVFSRHHFPWREPGYIYMDLAERVFVIYKTVIQEVHYWRSVARERRARGIECCEICAFEETMAEGKGICRECEFELCEIRGEDWFRRALLGDRPIDYRPIDTEIEGEGYKRLRIPDDEMRDLNAKFERTLSFYEDLDEEFEDLGQLEAQTARFVAIHRELERYFPRKRKRSPTIVPSETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI45</accession>
    <name>A0A1Q5TI45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI45"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI45"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="446"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="725" mass="79706" checksum="A05930FF74D3DE71" modified="2017-04-12" version="1">MSQLMEDGIGYSGKSPTSPGDWRKDSYFNHPSSGGSGSGRNPSTPSDGGRGSSHPRNPSIDGLTMGPLPPNSPVIRVIYTGGQTKVLDIRHCKTPDEVILCVLKKLQLPEHQYRNYCFYVLDGLDPDLSNCRRLTETELMEICDGHNKSERGRLILRKIHAGEPDVDELRRASQLAFDESQVTHQNALNKSNPRQKHKIQQLTGESWNVINTKQPLSPVGPRHRPSASNDHDQPSPDADRNHVATKLRSFFGQRPPSEMIIHELQSFFPSHDREDIAKTMRRSQRLSRAASRLSVVSNYSVASSLKDAPPLPPLPPIPPMPNIADTWFQPQGGAQAARASRPLSISKFNLPQASYRDSIASSSLQPLQEESPTEPNRKSYVSFDSGSDEPNLSRQSMIDESASVIATDGGSSNDRLSVLVADDGEEDDANLMSDFLAGNNFAPKNWMKGSLIGEGSFGSVFLALHAITGELMAVKQVEIPSATKGTEFDQRKNNMVTALKHEIELLQGMHHPNIVQYLGTSTDDQYLNIFLEYVPGGSIATMLKQYNTFQEPLVKNFVRQILAGLSYLHSQGIIHRDIKGANILVDNKGGVKISDFGISKRVEASTVLGSRASGGGGHLHRPSMQGSVYWMAPEVVRQTAHTKKADIWSLGCLVVEMFIGAHPFPDCSQLQAIFAIGSNQARPPAPEHVSPEAVEFLDMTFQLDYEKRPTADELLKCKFLAAPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI72</accession>
    <name>A0A1Q5TI72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI72"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI72"/>
    <dbReference type="OrthoDB" id="4525788at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="46457" checksum="B1D28584E1CFC99E" modified="2017-04-12" version="1">MQLPPLAVMATWPTPNYVDPPTRGHGVLIVNVVCISLAFLVVMLRLYTRLRITCSAGVDDVLIVIGLAFAIAMVAVTSLASENWGWNRHIWDVPETWLSTVQKLNIVFQIMFSWSSSITKISLLWFCRRLLGAGKGNFKWFNWAFIGSMIFVGLSCLMFTFISIFQCSPIKAYWDVSPEYPYKCLDGGSIVFSASVINIFTDFLVTALPMPLIWSLKLPARQRLAVISIFGLGIIVNVAGSVRTVYVWKSMVTGYDTTWLGWPVLIAAAVEINLGLICSSAPALRPLIATFLPRLLNSTRNINYSYNQRSRSQKLFSSTGRSRHSHMPATQNSRKGDYESDRFEIMRTVEMETWTESRLAHHDSIGHTYDIGTQNRAHSPESIEMKHGPVVFSSAASEKSSSSLTRDEAFYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI96</accession>
    <name>A0A1Q5TI96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI96"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38623" checksum="DC33FB44E6A26C81" modified="2017-04-12" version="1">MDAFVALLLAQVPNLRYLSLGPDVARPDRLIGMVLRSAICEPMNYKLPSFEHLQDVSFLLNLGQNYVREKQSKDIAALSLFYLPNIRHMSASIENLTTFSWPKAHLPTPSQLTSLDLTKIREIYLGELLSVTPNLKSLHWKWQYDHGLDDDLNLPILDLDRIAAAISHVRGTLTELTITGCCEIKGDDQWIPSIEIKGSLNAMVNWAMLKKLQIPWAFLMGFERDKSKRLQHVMPKNIEFLSITDDLKLQDNDSTQPEWPLWIWNEYKILKKLRLWLEDRSTCTPHLRRITLTLRTEWIFAEFDEWSPDIRQAYRDLGARTGVELEIIELDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJE9</accession>
    <name>A0A1Q5TJE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_7809</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJE9"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="17">
        <location>
            <begin position="70"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="76"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP00352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="49579" checksum="464A590F688BC54B" modified="2017-04-12" version="1">MAPTACVSPTDVCTIKNDLNSRDLLGQFSKHGDELLQSGLTAKGLVLDVLKKRAAEVDTDRCEPGEEDAFYVADMGEVYRQHMRWKMNLGRVKPFYAVKCNPDPEVLRLMAQLGNGFDCASKSEIDLALQTGIDPSRIIYAQPCKTKSYLRYASQVGVKQMTFDNADELYKIKAHFPDAELYLRILTDDSTSLCRLSMKFGASLDVAQQLLELAHQLELKVVGVSFHVGSGAEDPRAFLKAVQDARLVFDQAAEIGHELHTLDVGGGFCQDTFEKFSSILSDALETYFPPHIRIIAEPGRYYVASAFTLAANVIARRDVPDPLDPSRDAYMLYLNDGVYGNFSNIIFDHQHPIAKVLLSAADDSQPGTPNSAVMENNSYSIWGPTCDGIDVITQRIDLPGLLNTGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSETGASALLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJQ7</accession>
    <name>A0A1Q5TJQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein C17D11.08</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJQ7"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="361"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="404"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="66232" checksum="996ECD1C36EE1D13" modified="2017-04-12" version="1">MSNPVQSFDSHRRSAVFGRQPEELHIPSTGLINPNLASRQPASHDYPTTPDAGASTQVPAINVHSSAAAMQYATSGSAGGHTGATLPGSLTPGGQHRPPAVSVNTAPSAIPTLPQSTPQQASHRTSMINSHGHSRSSPAGFDQSPMYKQHGASEASKYPASPGAGFPPHTPQGSKYSPLGLADIRPPGDHLLGESLLSPGSLPYNGDTQIPTNSNYVAPWPIYAVDWCKWPISGSSSSFGGKLALGSYLEDNHNYIQIIDTHWTQPDPDTPDAAAGEIKLDYVKTAEATHSYPVTRILWEPPSSQKQSTDLLATSGDHLRLWSLPNTQTLQSSNSITRPSNPRDAPPAKLSPLALLSNSKSPEHTAPITSLDWNTISPSLIITSSIDTTCTIWDIPTLTAKTQLIAHDKEVYDVRFCANSVDVFVSCGADGSVRMFDLRSLEHSTIIYEPSEKTEKPVMSPGNSSPSGPSQSGLWPPPLLRIAASPHDAHLLATFSQDSNVVRVLDVRQPGQALLELKGHSASLNCVEWSPNRRGVLASGGDDSLVLIWDLINQHNAAPLSTPQAPGAPAQATTSERGPAAAWQCDYEVSNISWSPQGGPNHSGQPREWLGVCGGRGIWGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKH2</accession>
    <name>A0A1Q5TKH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKH2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045178">
        <property type="entry name" value="Fhl1/FHA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21712:SF29">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN FHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="738"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="738"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="816"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="898"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="958"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1009"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1106"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1237" mass="133231" checksum="6B53D0F5C8E6014C" modified="2017-04-12" version="1">MTAPAVGHRPPDPGPDTPMYDYGGSPNNPSPPTDSRSDSAIRDMQHNSAPTSKGLSATPIGIKMEPVEPQDLAGSETQKNINTQSAAGALLAQLLGNQSAPTNSVPTNGSPTTETGTGIATGSGHQEELKMGDEDDQMDQKMDLNNDFSFELNLPQDGQQTSASAGMQSMSNGGKSTDDIFAQLDATPQDGTHTEHRGSVAMDLSDPLNHAKTDLDQQPSLLPAFDFAVTPKNALEALQQNEILTAAYLSQSADLSALGYQDGSTSVAGSEPRIQAFAKLEFDDGHFYCNTYSFILGRDVRAARAAHQREYQYRQAVRSSRAKSSSGGNTSHTPNRMKREESAAMMGSVVSDRGGIMGFDPDVPPNLSGNNMPGKLDMNRRSSKSSFDGSVVPLHANPAQLQASTDYNALAMQSLQEGNGDPKPVDTLALLPSPDSCPTIPIHPPSTIDGTAAGHRGISRRHVRIAYNFDRNLFEMEVMGRNGAFIGADWLSPGQVRPLHSGDYIQIGGVRIRFLLPDVPIGETGADRMEEQLAEEEEGDQGSVDAEHEIDDTDKPLSDSESREPSSKVTKIILKTRDSDSSKALASIEAGGDGQPARRRGPGRPPKDGIMSKRERAELAREQKMAAKREANGGVTPPPPALPPKPPTSKAGKTVKESVVAESPPSSAKPAEKRKYTKRKKGDGMDFPLPSTEGGQFTTEQRPEEYVKPPPVKKRKPSRSPSPNYPPESAYTPEDLAKPPYNYAVLIFDALTEAGNPMTLKQIYRALKLKYPYFRFKCETEGWTSSVRHNLNGNSHLFMHAERDGKGWSWQLRPGASVEKEKKRRPSPPPPQPPVSVPPPQHYMPPMPHSYAPPTGAPAPMQNQHQHQHQHFQFPSIPSANSFSAASAPPQQQHTSPYAPPPVSTVPPPPAAPAPTAAPPVSAPAPAVPQVSAPAPAPVPAPAPAPAPVSVPAPSSVPTPVQSTAPAAVHVPAPAPAPASFPIPSALRGNLPAAFARTTPGTYTSPYASNPPPQAPQQQQPPPQNSQPQPPPISGPPQQHQQQQQQQHHSPYPPPQKAPSTPQPHINTQSQAYPPPAVPQYQTQHQHSIQQPVQLQHQQHQQNSHQPPPPHQHVPPPHHQSHQPHPPPPGPQTHHHQPPPQHQPQHQPQHHSMQSGPPPVAPESPSFTERANKAIDDFENVLMEDYEDKNYIREVLRSARARVLGNATESSFPGGEPKDEAVIMDVLRNLVGSLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL10</accession>
    <name>A0A1Q5TL10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Negative regulator of sexual conjugation and meiosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL10"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL10"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF75">
        <property type="entry name" value="AURORA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="573"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="873"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="912" mass="102371" checksum="FC7CAF81518189FE" modified="2017-04-12" version="1">MAEPSTIFEAATACRLLLRTATTTPRLMQEEWAENRLADFNLWAMGAGATSTMRASLDHRLRANPEAHTILLNLLLMLKILIQKCIDGAREIEDPTANLSSGQLARMKNVEDSLNQLTRLTIAIRKAGTRSRLQKADSSFDPDSPHIRSLRRHLEVLLLVRPDEHGNSDYSEQQLDPIRLSPIQFRLIEANLKRRNRFLYAQRHAQKLEGNLGHTKNTPRGKEASGKQSQRSAVNPLSQGGVALVRDDARAQSTTSATHVDDAIEIPPEQIPRSATTVVSVTSFRITYPKPPRFHDRQMLFTCPCCCQSLSVAIGRGNRWKKHLMGDILPYTCIVEECSRTDTFHMNKEAWLIHMNEEHGGTMQWVCHACSQKNIYATFGKSDDFTAHLEQQHGKGIKPGQIPMLLSSWRRKVPFKISACPLCSLQSDDQTALLDHTAEHIHSFSLRSLPWAPRERLEEDNDDQHNDDDDKEEKDGKYFKDHAYFDINSCWSEPSASSPRGSQLATDLESIAGSDSTASFHSVHEQRQQLTEGLLNQMPQELLGQVGTTDWLDSLAIDSDPEDRLGLILGNQFRLTSILGVGAYIVVYHALDMDTHSVSYAIKALSKIGKDARQLKFLQEEVRLNHEVNSHPNIVSLLRIVDAVDCLYLVFEYFPEGDLFANITEKGRFVGNDVLVKHAFLQILDAVQHCHSLGIYHRDLKPENILLADEGMTIKLGEFSLATRETSTSDFGCGSLFYMSPECQNPDPPPGSTYLSGPNDVWSLGVILVNLTCGRNPWKRACSEDATFRAYSKDPFFLRTILPFTFEMVVILSRIFVLDPSKRITIPELRSLIVDCTGFTEVPMPPQYKASRQPQTLAQNLEEPLQTLSLSPEDSVLEMPPDNPNHMLATSPLPSTAEDEDNTSIFQDGWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLH7</accession>
    <name>A0A1Q5TLH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TLH7"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="724"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="915"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1154"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1234"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1318"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1335"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1379"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP01049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1408" mass="158529" checksum="19ABAA8FB0E7A382" modified="2017-04-12" version="1">MGVPKFFRWLSERYPAISMLIAESRIPEFDSLYLDMNGIIHNCTHKDSDSPTFRMTEEQMFIAIFNYIEHLFGKIKPKNLFFMAVDGVAPRAKMNQQRARRFRTALDAEVAKDKAVQQGLEMPKEDAFDSNCITPGTEFMAKLTQQLKYFINKKISEDSDWQGVEIVLSGHEVPGEGEHKIMEYIRRAKAQPDYHPNVRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRQVSKKPKELEHQNFYLLHLSMVREYLELEFQELEQEGALNFPFDMERVIDDFILMAFFVGNDFLPNLPNLHINEGALALMFKIYKDVLRKMGGYINEQGVINVDRLGILVEALSQVEHRFFQAENSDAQWIKSKQLGLDGSLDLKPKPKELTITSAQKDILKKVKKYVLNRPGKASEPKPLDFPSTLPARDRAFLEKLADELRVQWSTLENENGDRFMRVQLPQSQGDDESDDDDEEDEEASMAVQRIIRKYERAKVQDMTAEEAQQAAEEKYDAKFQEWKDNYYRSKFGWGLDNEEEMKQLTENYVQGLQWVLFYYYRGIASWPWFFKYHYAPMISDVKKGLGADMNFRLGQPFRPYEQLMGVLPDRSKKIVPTAYWDLMTSPDSPIIDFYPRDFDLDMNGKKMEWEAVVKIPFIDETRLLNALKTKEQFLSPDEKARNSFGASLKFTYSPDVNFVYPSSMPGVFPDLPNCHCIENLFDLPTMDGLEPYNGLMEGVHLGEAALAGFPSVKTLPHVGQLGFHGVMVFQQESRNESQVITLLDPGSRSGIELAKQKLGKRVHVGYPYLQEALVVRVSDELFDYILPPGAQHVVSIPHTPQQIEQFKKKADRIESHYSKRLGMIIGSVESLVHIQPLKGMIKTDDGAVIKDFADIPGQETDYALQVVVDDVVNPDDRFIEKEALPIEEEFPQNSRAFFLGDFNYGRPVHITGHTDGKVNGLLAAVKDREPEFGKKHVMESEKKFPYMPSYSIARSLNLNPLVLAKITSSFTVDIDGTRVNLGLNLKFEARKQKVLGYSRRGQSGWEFSQKAVDLLHQYMINFPEFIAGIQRNPQKDRYAPTDFYPEDTAISKMKEIRDWLKSMESKNFERVPLDAEQLDSDIVMLIEQEADKIGLPQMQPKKVNGVPRGALLRPADVEHRLGNQTFKLGDRVVYCQDSGKVPIATRGTVVGLTRTSRALLLDVLFDASFMSGTDLGGRCSPFRGQTVLASSVLNLSYRQLITSSRAATSQQTTQKPTPLTVGGYGAPLGPNGQGQLKNAPAPPPLKGSFKGAVSGQAHPGGHVAMNNGQPMVLPHRPHPHNGPPRGPRGNGNRGTRGPRGGYASVDNSDPSEGIIQNNPNFHPRNMSQVPPPQGMDRGHGRNRGRGNGKRGQGGRGSRGGQGSQGGQGGAGGAPPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ74</accession>
    <name>A0A1Q5TQ74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein MAM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="56"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="322"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="672"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="747" mass="81002" checksum="DDD52782BD4CC13A" modified="2017-04-12" version="1">MAPHATHLLAARPIVLSLAKVIFFAFSHLPLAAAAPMLSPYLISSHHDIEPPNEADDPSLWLYLGISAALVLSGGAFAGLTIALMGQDEVYLQVIQTSGEASEKKNAASVLNLLKRGKHWVLVTLLLSNVITNETLPIVLDRTLGGGWPAVLGSTALIVIFGEIVPQSICVRYGLPIGAWMAPCVLVLMYVMSPVAWPVAKLLDKLLGEDHGTIYKKAGLKTLVTLHKTLGEAGEQLNSDEVTIISAVLDLKEKSVGTIMTPMEDVFTMSADTVLDERTMDLILSQGYSRIPIHAPDNPMNFVGMLLVKMLITYDPEDCKRVREFALATLPETRPETSCLDIVNFFQEGKSHMVLVSEYPSEDRGALGVVTLEDVIEELIGEEIIDESDVFIDVHKAIRRMAPAPKSRVPKGKIVEEPPMATSLTDGEFDGTAKSSPAPTQMSSELLRRRSSVEAPPPRFQLRRQNVDQPSDSHDNWFTQRGATDEIREHLKHLGPSNLASRPRQTRYTSVKIKRSGNSPSRSAQTDFESGHSTSDSQRFMTSTGLQGGIGAGLVSSGADAKDGAHALKLGYGTIAAHDHVTKGTNAQQYKDLPNVSIPEAVREEREDLNRSASTRKSKSHSSSGTGSIRSTDSKSVEFIYHHRGPTRSGSITEQIVDVNGIRKVVLHANCSSSSEGETGENGASARLTGISSPVTKDSATNTTNTTDLQTSAHEPQTKKRRRKKKHGKHHNPPGGDGAREDQPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ98</accession>
    <name>A0A1Q5TQ98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="32935" checksum="8A00E2A75186C96B" modified="2017-04-12" version="1">MLGNFIPTGYSMESLPPELISQVLDFIIPATGSRRWPEIKLAGYATLSRRWQAFIEPCTFSDISINDPKRLEEFQQIISISHRRSYVKKIYLRVKLESYDEEARARFETDEEHQRNNKIFNSTISALFRILADWPKEAGIELGISAWCPSDYCDRQRRLAAAMWRGNDLLGWRYEKSYLEFSRTTTDSECPPVHAVTYLSVEGLRDERPIEPASSVLIALKLPQLNRVHLMMKDEWRRDKQTRQRLRNGSSQVLVEPVVVIILAYSKSSYMSYPTFSKMKDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQD0</accession>
    <name>A0A1Q5TQD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQD0"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP02397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="479" mass="51865" checksum="52CA043068B9F93A" modified="2017-04-12" version="1">MNPDGRAIRVLAVLDPSEPHTFVEPAKKIHESQDVSAFLTSKAYSGIMTFILQLNRAMFPAKLPDGTIQTWPLGSDAVQFSAPIRQLQRLLSKLEDIVQEVPPDTGPRRFGNISFRRWHEVLASRASDLLRECLPAELLDRRSPTGQGVTAEAELKAYFLGSWGSGQRLDYGTGHELSFLAFLGAIWKLNGFPQSEFGVEERALVLGVIEPYLELVRLIIKTYTLEPAGSHGVWGLDDHSFIPYVFGSAQLSPAIDATNLTPEEGSLPDAPDPSGIMKPVIVERERRLNLYFSAIGFIYDVKRGPFWEHSPMLYDISGIRAGWGKINKGMVKMYNAEVLSKFPVVQHFPFGSLFSFDRDPNAVMPPTTVHTTSGPQGRPVVPDAGPPSTSTARPSADAGTKAPWATGGSSTRAPPPMGATAAPWATGRSSEPTDAPPALPDTSRLPPGPMAPTRAPWASAQPPPPPPGGEGPTKAPWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRM1</accession>
    <name>A0A1Q5TRM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein cps3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRM1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRM1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP02869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="542" mass="57851" checksum="B4DA08F091E910C3" modified="2017-04-12" version="1">MLSASRPPSSRPNRPEMRGRAPLPVPSGLQQNGHSRNPSSLDMARSPPNPSNKNTKHVPCKFFRQGACQAGPACPFLHSTDAAIDYAPCKYFTKGNCKFGAKCALAHILPDGRRVNRAGGGGGGAGGMGMGGGSHLNLGGRVNPQAYVNQDSALTNSVLSQQRLNGHEPRYNQQLAPQDESGFVQGQQQGPYDAIPTIDTGLASDAGSKYGSPVDDVRFPMSPSARHLTALDAPLPASFDSQGISHAARYGPVAASVPSKFGLGELSSPPAQRMGPSDPFRNIRDVGYDMRKPSSNIGSSPPAPEDSTGHRFLHSSRPVKTRMLSASVPRPALLDDWDENFPMEEDYLPMNLHDDVLTPQEKLRRMSRTDNDLSSSHRDVSGFGMTSASFSKNGSPLASSPSRFGALFAKQRQKKEEDSIGSSFPHIGSPLRESSLNPIGSPSLGPIGSRTSIDGSPFVSSPGRQSSMSMISEQLSGLSLHPGSARYTSAGPGRLDRTISSTTSKIEEEEQSDLVFSMEEEEGNKRNSSSWNSESKESSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT22</accession>
    <name>A0A1Q5TT22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT22"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT22"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="16909" checksum="C43735EA434AA2DB" modified="2017-04-12" version="1">MPAILAATFLESTTYVREGSQPKELFRRVGSRDSALPELWSEQHECLHDDIGQLLEIELSRWPWGYTIYRSVYTPESDIHWEAAVDAIRANIFASLDDELQHFKSKNEKAHRILCDGYRSLVFQDKSQLDGATIDQVAKKLQRFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXN4</accession>
    <name>A0A1Q5TXN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXN4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP04994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18800" checksum="EB4FE5C3C2F133A5" modified="2017-04-12" version="1">MPEGFEQLGMRWKLNRALYGLPARYYLIDRAPVYTTLPVEEIKPFDGTATPAKIKVYQGKVGSVQYPTTITRPDAAKAAAKLSQFLRNPGPQHQRAVDRVICYLYITRYLALQWWMRFLERIAFKPSHTITLRCDNQQTVTLLTFEHAKIDTKLRHVDKMGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U037</accession>
    <name>A0A1Q5U037_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lovastatin diketide synthase LovF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U037"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="10"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="935"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2481"/>
            <end position="2562"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="935"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="967"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP05835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2572" mass="278129" checksum="B047650B3D7CE6F0" modified="2017-04-12" version="1">MGSAGPAWASEPIAIIGIGCKFAGEASNPSGLWDLLAEGKSAWSEISASRFNPKGAYHPNNEKLSTTLDPQFRLQLESVYEALENAGLPLAQVAGTNTSVFAGTFVHDYRDSLIRDEDNLPRYLLTGSGTAMASNRISHFFDFRGASMTIDTGCSTALVALHQAVQSLRSKESDMSVVGGTNILINPDNFKAMGSLGFLSPDGRCFAFDSRANGYGRGEGVATIVIKRLRDAIANGDPIRSVIRETLLNQDGKTETITSPSKDAQQSLMRDCYARACIDPLGTQYFEAHGTGTPTGDPIEVGSIASVFQGKKRSAIEPLRIGSVKTNIGHTEATSGLASVIKVTLAMEHGMIPPSINFKNPNPKLSLEEWGIKVARELEDWPALPGTVRRASVNNFGYGGSNSHVIMEDGEYWLQSLGTGAFSKSNGAQNGIDSLPSPSYETNLFILSGKDELTTKAIVSNLKKFLDEQEKKGLSESDAKALLQQLSYTLGQRRTVFPWIATYPLSITQGIAAAATALESRNFRASKVASLQPRIGMVFTGQGAQWYAMGRELITAYPVFGASIKEADAILKDLGADWSLMEELHRDAESTRVNGTGFSIPICVAVQISLVRLMDTWGIKPTAVTSHSSGEIAAAYAVGAITLRRAMGIAYFRSKLAADLSQRSTAKGGMIAVGLGHREAERYLKNLTSDTKAVVACINSPSSTTVAGDLPAVLELEEVLQKDGVFGRRLRVETAYHSHHMAPIAEDYRKALRNMQDGGAKMGNRTDSIVYASPVTGYRVTNATTVADADHWVASLLKPVLFVDAFTEMVLGDFDPESDASPSSIDLVVEVGPHTALGGPIQEVLGLPDFEGIKLPYYGCLVRHTNAMDSLQALAANLIREGYPVDMEAINFPHGKGSEIRVLTNLPPYPWNHSVRHWIEPRVNKALRERSQAPHHLLGQLVPGTNLNVPSWRHILRPTESLWVRDHMIQSNILYPGCGFISLAIEAVRQQIDLIAEEQGESSPREIAGYQIRDVDVLQALVIPDTTDGLEIQTVLRPADEKAIGVRGWKQFEIYSVTADNEWTQHAHGLILVEFGDPQQATGLGLEKNKKRLDPTAGYAKRIEPDDMWNVLTALGLQYGPTFRNIKSIIQSGKEMRSISEIVVPDTSVAKELPYNHVVHPALLDAAAQATFTALPGAESRQDSPRVFQSIERIWISSKISSQIGHAFQADTFLHRADAQGIEADITMVDKDAGDGTKPVLEIKNLIFSSLGRSASTGDDKPWEKQLCTTVHWAPDASLGIQTASLRHELDQDEIRSITDLRRVCLYFIQEALATISADEVRQVGPELEKFYTWMQDQETKAKEGKLGPGSATWLLDTKAEREIRTDLVAKASVKGSIVCRLGQNLHAILRGEKAMELILDDGLLEQYKQQDHPRTLSQAAALLRQIVHRNPRASILEIEALSSDSTLGMLQALGTTESGGPLAASYHIAKKSWDEESQTAALGEFAAWSDILALETLDIKKDPSTQALELQAYDLVIADRSLSSNNSITDCLGHVHSLIKPGGKLLLVETTQDDLDRQFVFGLLSEWWQDNDELAGEHCPSLSLQSWEHSLKASGFSGVDVHIPDCEAIEMYTTSAMLATVPFATPTQPPPSQDIVLITSNKAEPALDSTWLASLQHEISEAGSGAGSRPNIFAIESLPLASLAGKICVFVAEIEKSLLRDLDTETMEGIRTMVMNSKGLLWVTRGAAVDCQDPELALAQGFLRALRNEYPTRLFATLDLDPVTPIWSVDSVPAILQVLQASFGSTASEKSYTVDPQPGDFEYAVRDGVILIPRILKNQVRSKAVSPDDVADQGPSTLVSQPLYQLDRPLSMHVGMPGLMDTIAFDDDPAMAAINDKSALPSNLIEVEPRAYGVNFRDVMVAMGQLHERVMGLECSGIIKRVGAEAAIHGYAVGDKVFCLLRGPFGSRVRVEWTNVAHMPEGLSFEDAASLPVIFCTAYICLIDMARLRRGQTVLIHAAAGGVGQAAIMIAKHLGLEIYATVGSAEKRDLVKTKYGIPDDHIFSSRDASFAAGVLAATHGRGVDAVVNSLAGPLLQESFNVLAPFGHFLEIGKRDLEINSHLEMRPFTRQVSFSAFYLLASMQHSPLEVHRVLNAITQLLESQAIAPVHPVTAFPMGDFAKAFRLLQTGKHMGKVVLSTGPQEMVPVRPRTPTAKFSPEVSYLIVGGLGGIGRSIAHWMVARGAKNLIFMSRSAGRGGHNRVFLNDLRATGALVGAVSCNVSDKDDLIRALRRCEEIGLPPVRGVIQAAMVLQDTVFEQMSLANWQAAVQPKVHGTWNLHQAFDTPGSLDFFVILSSVVGVTGNASQANYAAAGSYQDALARWRVARGLPAVAIDLGAVKGIGVAQETAGVLSRLQRIGHIPINEEQVLAVLDSAILSPYEPQVVIGLHTGPGSHWKIDGDSPLGRDARFVALQPAEGGQKNAGAADGSGSLGSRLAAASSSVEAVDLVGVAIAEKLSDIFMLPASDIDLANKPAHFGIDSLVSVELRNMLLQHAGAEVSIFGIMQSPSLAALAADVAAKSTHVQWDRFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U083</accession>
    <name>A0A1Q5U083_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U083"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U083"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="13202" checksum="D52AE6C58D7DDF31" modified="2017-04-12" version="1">MSGRYAQQLHMQGIVNPLALQGGPQQQQQWSNNLGFNPFDVMDLMNLADYANLSFDDSQMASLMFNSQMPMNYMPSGFFVDPKNDCEDFNQFLNRIRRRSPPSDFLLPFYRCMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0Q9</accession>
    <name>A0A1Q5U0Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000600">
        <property type="protein sequence ID" value="OKP06059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0Q9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="41632" checksum="86FE15315231578A" modified="2017-04-12" version="1">MDIRGLTYPSGLIPTPHGDLILDPQLRGQLYHNGITLTNSTVGGAFLFAYNFAYSSTCRDRRRLASWRDAARQVRQIWEEALREKEDTVLPLLTTNTIRDSLGKRPARLPDTLWQMLRAHCPIRTVEEEQQKQFKEAKPCIVPDTTFARAVDRALRACFALLKFTDHIQVVYIRGLTGKVDIYFDKGQGTLKIHCRWLDFACMHHWSLCRPWSPTNLADTNAPFFCCHVVEELLIGRRLRYLPHSIKLKPYPGGILVSWEDNETESFRTLGSSGPDYHVVLHGGDCANAEMALLHDKTALPNELVPCGCRYQFARQTHRMCLFTGLSHTSTYYAMSALNEDRAFYGVPSDRVSPGLYEKVETHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1J8</accession>
    <name>A0A1Q5U1J8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1J8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1J8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13030" checksum="06DE51B294DF1E98" modified="2017-04-12" version="1">MSYNKPTSPPPSYPAPVHDGAGYHPGSPPPQGGGAASDYYGGQQQGGQGYYPQQQGYGPPQQQGGYYQQQPQGQMYYPPQQGYPPQQQQGYYAGDRGHGGGSGAGGICAGIMAAMACCCCLDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1W3</accession>
    <name>A0A1Q5U1W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6455</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1W3"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="540" mass="59367" checksum="7022EBB0F9F3BB0D" modified="2017-04-12" version="1">MAFTHDEKSPEAGSEHVEEPVDVFHAVRGTAALEVCTRLEPVQKLSKRMIQLYAICSLAFLGSTMGGYDGSLMGNLIVMQPFQDQFGAKILGVQTGIIMSMYSIGSVCGLPFIGPLTDTWGRRVGIAIGCVFIIMGTIIEGVSHHLPQFLAGRFFLGFGGIICNVACPSYVVEFAHPAYRGVITGSYNCCYYLGAILAAAVLRGCVHYTTNAAWLIPTWLQMLFPCILLLGCICFPESPRWLYVHGQVDKCRETLIKYHGNDNPESLYVRLEMHEFAEELELDGADKRWWDYRSLFNSRAALYRAILCAVAVSAFSQLTGQSGVSYFLPAMLNTSGISNTATILDINLGITLASSAAACFGASQMDRFGRRKMLISCCVALTLLWGGMVGGTGGYAIYKSHPAADASITFIFLIGIVFSAAYTPLQALYPVEVLAFDQRAKGMALQNFAGNAAGLVNQFALPISLDVIGWKTYFIYMGVCFCQAIYYYIFMVETKGHTLEELNEIFQSRNPRRAASLQKHEVDEEVDKVQRLKQMAAHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3A6</accession>
    <name>A0A1Q5U3A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3A6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3A6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="179" mass="20137" checksum="56AC898D45A6BD44" modified="2017-04-12" version="1">MIEESTISETLHSIPGEPILHMNFTELLKNTTYFMHAQKVKEVRAQPYQVEWATVSSAIKRWQGVEIVDLSSICTPNPSKVAIILEELGIPFHREEVPLTEVEKPVYEGICPNGRLPAIKDPNSGITVWETGAIIEYLILEYDPGHKLNLPGRTPEAYAAGFSYRSDSFIEVDNLIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3U6</accession>
    <name>A0A1Q5U3U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADIPOR-like receptor SPBC12C2.09c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3U6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3U6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP07152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="245" mass="28373" checksum="8B454F088DD5418B" modified="2017-04-12" version="1">MAMASVPRRRASSPEPSIASQEFGNHSLGPQFLRNLFQAGKVRKTLLSFGELEKWRQDNEYILDGYRPASGSALDSFRSWLYIHNESVNIYSHLIPAVAFLLGEWYIPGYLTTRYHNITGNDSFIFTFFFLSAVICLGLSTTYHTMMNHSYKVEQFCLRLDLVGIVVLMLGDFVSGIYMVFWCEPLQRNIYWSMNKFPERWYPGKFNIYGSSHQLFHILVVFAVVAQLTGILWAFDYNYTNRTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5W7</accession>
    <name>A0A1Q5U5W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5W7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="258" mass="28877" checksum="BBAC0C785AF29EFB" modified="2017-04-12" version="1">MSGRSLSATGSDSYWANEPIAINNWVPGVNFVEKCRKRATTTDGLGILIPGPALKGGLLSMLQHEPYWAEASRKEIVHSNGRLMERGSYCSFSIGHVLSKVAFEAKKFHESRVLNHHARNGRELKFVCSSTLLSVPAGNLCSGGRLVYQTASARLDGGKQIFDNIQSIPEHAQLYFNSEASTFRRAQVPHLGRDLSHFVRRTRQKLHALKLRCRRFVLTILDAVVWYQVPSGVSIVAEDTEIPQESYEGEALRRKDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U719</accession>
    <name>A0A1Q5U719_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U719"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U719"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="183" mass="19579" checksum="10F5A2D98A6AFA2C" modified="2017-04-12" version="1">MANRVSIGQGTKSVKPSPVILGQPLKDDLGGIGLWSTPNDFIKLLTALLRGGQPLLTKASVDILCRPQLSDASRAAMPKPLGGQMRRVLGIKSVDDIDQADHCLAGTITLKDIPGRRPSGTVNWSGLPNLHWWIDQQTGITAALFTQLMPPGDAAVTGLLIELETVLYKALRKRENAGVSGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7A5</accession>
    <name>A0A1Q5U7A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7A5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7A5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="550" mass="64214" checksum="1D453500D4C01CB7" modified="2017-04-12" version="1">MANIGAKYLWIAFNKQADWGFKQARINTLRQEYEKELENYRGRISGKVLTHRLDAKSAEGAFNVLEDMFVTMRDPRDYSRRLPPSGPSKKDLALQRLVEREIAQDDMDPRVFWEYLQNDNLTGTRTMVLFWILQTHYAIQDYRKQKGMRDFPGLRGFYGVLRHSPILMDSELWKEYYWSSQFWSSYATKNWLPPTLKPLSWVSFMPDRSTDLAAVQEDPDRLLRYAFGILQYVYKRDLHRIGVTARALLALERSTMRLRKSYPFISSYSETQAYFWLQVVQIALRSLYMIYPQSEKEVIGCISPVSRLPFSGFKELVEIDSESWNRCYSRKVWDSMEARSQYISPDIRPLNSLIKKSWISNDNPIFVQRMKALLTEMNPPEPSVEELSFRATFVLDCSQELNARNPVIENHKHLLLFLYTNLVSDIESQNSEKAPSLRAQRAKELFSGVSGPLVHALTHKNFWFQQFLTALDFAESRKSETDASSDFSTFAGFIMNSLELVNEDLPIQFYNPKIWHSEKARQTIIAPDKREMTNILELVATSEMSDWVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA72</accession>
    <name>A0A1Q5UA72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000527">
        <property type="protein sequence ID" value="OKP09369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UA72"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14850" checksum="13818D6F54D6C6EC" modified="2017-04-12" version="1" fragment="single">LIASNLSKYAMKSFSLVSRKCRAVSEPXMFRTIEITYSEFDFTVLEELSRSPLAAYVKILHYDASELFDPGETLSIEVQLSDVRLKSEEDTPYRWQIDDPALEPLFQKHLSKHSVGTYMLLHKMVGQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAC5</accession>
    <name>A0A1Q5UAC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAC5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270865" evidence="1">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="520" mass="57853" checksum="CE1EBFCE33E93D63" modified="2017-04-12" version="1">MRVHLHWSRVASLGLLGASLVQSAELSKQSKQLFDQSMTLLDDIYDSDASYLNYFYFPLAAGAHETRSTVWYSVGLLQRNQGTDRDEAVKILKNVIGGQEKNESVLWFGDYTVYPEQPTVGSPAYDPVIYNSWDPNWRGFIGTALILIYEEFGNLLPADVKDLVIESLYNNTVGDSYRVGGVDNDNLYPAYSNAWLMRTVVTSWTGHHLKNANMTSAGDTDAQKFLDLFDRNHTLSEFNGPTYAGVSLYALTIAAKYLSHSTSVIGQHAERVIQDIWGYESQLWNPNMRNFAGPWDRSYGYDMNKYVAIMSIWIWSLIGKEHVWQTKAPIWSMTHADDFEISPIIAVLSNFHKKLVPDAALKRLTSFSGEHTYHGHTYAPPADYEPRNITTWLSSNLTIGTDSFNQSNVGGYSKDSSSFSPSVVQWIRPGGSVGYFNLYPTQTALQAEVSPYALNLTYPLGNSSSTFTFVLASNPLGSKRDISGFEDVDGLKIEVVGGTVNPVPEISFCGLVGGTCDIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAF8</accession>
    <name>A0A1Q5UAF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAF8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036141">
        <property type="entry name" value="MukF_M_sp"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140570">
        <property type="entry name" value="MukF C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="152" mass="17723" checksum="E47DA60FE0FF35AD" modified="2017-04-12" version="1">MPDLCQPQITTFLESWRKLRAAVIEMGPYAKMISQVEDVLEEDTEIKTKLKWSEEKIKSLNHVIDEMIMKFEQRHLALQEKHDSSLHKMNILVQDTKKQLGICCGELEKSAQNYRALEDELRAQNDSLSAITEKYQELWRALGFIEVDSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAH5</accession>
    <name>A0A1Q5UAH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAH5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60737" checksum="25DF76681C9D2CE8" modified="2017-04-12" version="1">MEGWATSASARSESTQGMSDKTGAKCMRCQRSGRECVPAPGKSEELSFRHGQNPSLRGKGPPRYGESDLTFPNDQVWVESSSEYSFKDETDQTAAEYHVVPVTGHLASRSPSEARSTPSSIMDPSLPGPSNSAPFYIADSRGGSRSTSAHSPRSSSTPVSSTPRLANVNEAYLLRHFQRHLAPWLDAGDPERHFCADVAGRANESPLLLYACLAVSACHLSRTANTISPDVADSYHERCISIMLPVLDKPEFQIGIDILLSSTVILRFFEQISSHTPSNDPQRHLLAGSVYISSHVDCAISGGLASASFWVFVIQDIQFALTYQKCLRLTFAPFDDRLRRWWVAKLVLSDGDWVNRAIWLLAETIDFCYNVSGRNYGGHLGIAGENALKQRIRDWEVGRADTFTPLHVSPPDHRAGKPFPVVWYTTLWHFVLPATAVQHVCLAKALMLIREYEVYDYTIEQRAKVKEQISENLNYLFGIAFSADDEPSLRIMACHALCACSAWIDDPLAQNLLFDLLRRTERDNGWPWAYVEQRILHAWQGNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAR3</accession>
    <name>A0A1Q5UAR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000490">
        <property type="protein sequence ID" value="OKP09565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAR3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="202" mass="22064" checksum="D1E6BFF977BC5589" modified="2017-04-12" version="1">MDKYLDFWNLMAYDYSGSWDTTAGHDASIYASTSNPSSTPFNTDQAVKYYISQGVAASKIVIGMPLYGRSFLNTNGPGTSYTGVGSGSWEKGVWDYKALPQPGAEVSYLEQPIASYSYDSSQRTMISYDDPQVARKKAEYIMSKGLGGGMWWESSGDKKGSDSLIKTVVNKFGGVCALEQVQNELNYPSSSYDNLKAGFPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAZ5</accession>
    <name>A0A1Q5UAZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ-loop repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_4917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAZ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6310" checksum="301E09D589A83ECE" modified="2017-04-12" version="1">MSDGNVTVASNVLGTIGTVLWCIQLIPQIWYNYRRKKTDGFPAAMMLLWASCMVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB41</accession>
    <name>A0A1Q5UB41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PENSUB_4966</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB41"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OKP09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="638" mass="67245" checksum="6CC8455124025802" modified="2017-04-12" version="1">MNHDDNDIPAPPPHRYTPSLRNNSSVTPGVDNLGPSSVGGGISGIALGVANSHDRLSGVDAVRGMDHHDGFSGPAERGYHTTGSDNPYIPYTPDLGSSDSLRPEQSYGSNMALGATGYPPGVQTPGQSSIQLSDGGSSNRRSMMDQYSGSSYNGGIVSDGPYQRQSQYSTGHVPADINPDEIADDGDDEFIPRSRNAAAGAAGGAAAGGVLGGMFNRGGTANPQYGPVPGGGLEAGSRSAAAQEKAAMGGGMSSRKKRGLIAGLVLGLIVLGAIVGGAVGGTLGTKHSSGSSSSSSAANANSATSDTAENGDLNKNSAEIKALLNNDNLHKVFPGMDYTPWGVQYPLCLKYPPSQNNVTRDLAVLSQLTNTVRLYGTDCNQTEMTLHAISQLGLTDMKVWLGVWIDTNETTTTRQLDQLYKILDDTKDPSIFKGVIVGNEALYRAGSDLQSAETNLISYIKGVASELKKRNLNDMEVATSDLGDNWNADLVSAVDVVMSNVHPFFAGVDVDVAAAWTWDFWQSHDVVLTKGTTKKQVISEVGWPSGGGKDCGSSPTCDSDTPGSVASVDNMNKFMSDWVCQALENGTDYFWFEAFDEPWKIQYNTPGKEWEDKWGLMDSARKIKSGLKIPDCGGKTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB79</accession>
    <name>A0A1Q5UB79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein yop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="15956" checksum="DA98CC5EE171D65E" modified="2017-04-12" version="1">MASFQDRAQHAVAQLDKELSKYPVLNNFERQTNVPKVYVILGLVGVYFFLVFFNIAGEFLVNFAGFLLPGYYSLQALFTSVAYSFYYIFKFVLILWMALPQTSGAQVVFHSFLQPLVGRFFSQSGTSANLRAQAEAAKAHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB91</accession>
    <name>A0A1Q5UB91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PR domain zinc finger protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000462">
        <property type="protein sequence ID" value="OKP09748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP09748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="23182" checksum="405B9D1A2D9666A8" modified="2017-04-12" version="1">MYRCETCTASFAYEDEWENHMVNHHHWLECETCTRIFRTRVSCNQHMNDTHHWAPRFECETCNKSFRSANAAAQHMADVGHWQPKTCCETCTKKFHNQKAVNQHMDALGHWAPKIACDVCNQKFYTPAAANKHMKDKNHYRNYCRDCDRRFENENNLKMASLFLSTLLEGPCVLTMENSPTASSLKDSPRLQRPMSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBQ1</accession>
    <name>A0A1Q5UBQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000437">
        <property type="protein sequence ID" value="OKP09889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBQ1"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="39"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="541" mass="61727" checksum="16692DD2AF40CD41" modified="2017-04-12" version="1">MSPTHQHQRRTSYATRSRSTGIPASTLWRRANNKPSIVDKAANQQYLTPQEEQALVEYVLRLANNGYPLPVKFLRSLALVIARQRSSTFQIIDPSLEIRPPGKNWPQGFYLRHPQLKARRLRAIDWKRDDRQIEEKVQHWFAVIGCELADPAILRENVYNMDETGVLLSVLNSLKVLVGKDDLRKHRGTTVKRTLVTAVECISADGRSLHPLIIWPASTHRGSWTTHATPGWHFACSKTGYTNTEISLYWIEHVFNPQTRERAGDRPRLLICDGFGTHESLEVMKFCFANRIILCRLPSHTSHKLQPCDVGVFGPLKTAYRAQVEQACRAGVGTIGKPHFTYLYDRARKEALTPRNIRSAWSKSGLFPFDPSRVLREFEATQPEKQIVVPVDPATVSSNLCCTPNTSDYFALLRREVEQDTQNLDSVCKHRLQTLSRAAEKVFAERALLLEENRILFEQNNEKSCRQSTGQTVVGHAKVMSYEDIVEAQKKRDMTVAKKGPTRKKRSKAGDKLLTKMEEKRKAEQEIQAWNISDYCSVLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC82</accession>
    <name>A0A1Q5UC82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC82"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF24">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="55239" checksum="3E9791E1C40E9003" modified="2017-04-12" version="1">MEKRRTSRACDACKRRKVRCNGQSSCQQCTHVGLRCTYSSTLSSQTRKKNLARGSVIAECRTLSTQPSQRSQIEGTLASRVLPLSIPASIVSHPNPSFFHEFLHEYERYVYPMSPVIPAIEVQEMIANMDDDRDAASFVYIFAAVTLNLTRGEPVQEAPATRERIATLLTRSLEHRRPLGFDSQPTVLSVICSLFTEMCSVGLRRLDMGFLYLREAISLLYMLHAHSDEALAEIEMPERARLQRVYWECFIHERFTALTYNRPPCLSPLRGLPDHDPSLPEDVEAGFNHIINNFCLVDREFLEYWLCERTGVSSEWIENKQRQLEDNCWHREVSQLPGMLQADLIITRHWLRTLTWQIALSNTLLSSSPDSCLLLSLSFPLRLSNQLRQFLVTIPHDMVGIHGSGILEKLYEIANVITDVVLQLPHASGDDTIQRIHDIIFLKNFVYSFAGFQTLRPVVLTQKFEMIREKYPEIREIELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCJ1</accession>
    <name>A0A1Q5UCJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCJ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7696" checksum="1E168E502C9B96F7" modified="2017-04-12" version="1">MARRFLRGQNMAFGLSVFLFTFMFLPTFLILLAVVVFFVLAYPRLRKSYASDGDREVKPHQIGEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD51</accession>
    <name>A0A1Q5UD51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein TOXD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000350">
        <property type="protein sequence ID" value="OKP10390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD51"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="37564" checksum="DFEFAC3627AFEEED" modified="2017-04-12" version="1">MKEVINLAGPTVKIVESPIPEPNDDQVLIKVVVSGSNPKDWKVPELAASGNNSLDILVEAKKGVNQGDDIAGVVEKRGDRVAAFHEMCTPGGSYAEYALAWSHTTFHLPKHTSFEEAATIPLAALTAAVSLYAHLRFPPPWTPAAKPTPFIVYGASTAVGSYAIKLACNSNIHPIIAIAGKGSRYVRGLLDQSKGDAVIDYREGVAATTKAIRDSLEKAGHSSVRHALDAVIITQSAEVLKQSVTAGGQVDFVLPNDLDISPAIKSITSVGSVHKQPGFGDYEELGFIFSRYFTRALQNGRFSGHPFEIRPRGLDGVEEALKDLKAGKASATKYIFRISDTQGLFSAGSAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDW9</accession>
    <name>A0A1Q5UDW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDW9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF11">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="28465" checksum="78AB9D31399D82B4" modified="2017-04-12" version="1">MDHARGKVAYAINESMPEPIPSAEYYFTYAFTEPERKALPVYYHLVQSIGCYEMGQKQACIEHLQGVSVHLKSVFQIYYEYIVESKDPRHVFTAYIQGFHGWAAGELINDEYVEYDGSSGAHLVLFNALDYFLGLEPFFHEQDFIKYFSYSQRRFMASIKAHAFRPAAEQADNTGLVQQFEKIAKQLRTFRSAHRKRTSQYLSVECPERLVMTAESSTMDPEAHGLTVQDIVKHVDDGLREKMVCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEU6</accession>
    <name>A0A1Q5UEU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEU6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEU6"/>
    <dbReference type="OrthoDB" id="4890185at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15220" checksum="9F44068A7ADE15CE" modified="2017-04-12" version="1">MPSTPTHKHLSRDERLKILTLRETGQTYDRIAIKMGCTSHQVHYVCKLNQATPRKGRGRRSKLSEDRIDGVIEWMHASSDNRSKSAHQIVTDLELPVCAETLRKTLKARGISTYGDARTQSRDFKFGGRLLTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEV9</accession>
    <name>A0A1Q5UEV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEV9"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF1">
        <property type="entry name" value="YALI0F01606P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="389"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="596" mass="63540" checksum="EC832C44372EB676" modified="2017-04-12" version="1">MSDKHYFPSTSANSLVPRALRALVSANDHLTLDFAERVVANAFHDDSKVSIISGGGSGHEPAWSGYVGDGLLSAVACGDIFASPSAKQILAAIRMAPSKKGIILLITNYTGDRLHFGLAAERAKAEGLVENIAILHATDDVSIGRSKNSHMGRRGLPGHVFTMKIIGAAAAEGYSFEQCLALGQAVNAHTVTIASALDHCHVPGRAQQSSVSDDVVVIGAGIHNEPGQLHISPAPPVEELIERCLKLLCDESDAERAFVKFEGDDEIGLLVNNYGGLSVLELHALADEIQIQLGSRWNIKPRRTLFGAFETSLNAPGFSISLCNLTAAARQSKEPVATLIRQFDSTTTAVSWPNTIRPSPTQQRITLDHLDAQANGHTADSPSIKFDSKLLESAIRTSCERAIAAEPRLTQWDMVMGDGDCGEAVLGLAESILQRVDKGCTESGDVLEVIHSILQDVDDMGGTLGAIFGVLLSAFSTSLRKNASESKISPSSAEFYATALESAVTSLKSHTGARIGDRTVMDVLLPFEEEFSRTNDLPSAVKVAAKRAEETRYLKAKFGRATYVGEASTQELPDPGAWAFYEIVAGLAHGLGFVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFF7</accession>
    <name>A0A1Q5UFF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AP-3 complex subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFF7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="6">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="99" mass="10567" checksum="847FF51D7F6A5A39" modified="2017-04-12" version="1">MISTSTESPLALIDLIQVFVEALDRMFENVCELDLIFGYETMHAVLSEMIVGGVVVETNIEKIVAGVRSQEGTMGKKKAVQAASASLGRGALPGLGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFH8</accession>
    <name>A0A1Q5UFH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFH8"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="88"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="51362" checksum="834387BA737F2830" modified="2017-04-12" version="1">MGANHEHATPSIDSATTNIAPSDNSTPAMSDHVNDDLEKGTRTADPIESEGRDVNGEPLSEKSEAVTPALAGPPSPGPPPDGGAEAWMSVLGAFCGLFVSFGWINCIGVFQTYYETHQLSDMSTSTVTWITSLETFVMFFAGPIFGTLFDNYGPRWILLGGTFFHVFGLMMASLSTEYYQFILAQGICSPLGASAIFNASVNSVSTWFAKRRAFALGVTASGSSLGGVIFPIMVSNLIPKVGFAWAMRICAFLILFMLGISNITLKSRLKHTKKPFDIMNFVRPLKDVKFVVTVAACFCFFWGMFLPFTFVITQAQRYGMSEHLSQYLIPILNAASVFGRTVPGYMADRVGRYNVMIFFSYLSAILVLALWLPSRSNAPAIVFSAMYGFGSGAFVSLAPALIAQISDLREVGVRNGTCFSIISFAALTGTPIGGALVPDVLTGSYTRLQVFSGVVMLAGASLFVVARIVVGGVKMGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFS0</accession>
    <name>A0A1Q5UFS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_3324</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFS0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFS0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="13">
        <location>
            <begin position="514"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="659" mass="73240" checksum="9C7386069DAE4C3F" modified="2017-04-12" version="1" fragment="single">MGAKQKGGGSKPKNQADEVEETLQAVVLADTFETRFEPFTRDKPRCLLPLANTPLIEYTLEFLANAGVEEVFLYAGAHSDQLEKYINTSKWRAPSSPFKQLTFLKSTSTSVGDVMRDLDGKHLITGDFIVVSGDVISNLPIEGALTKHRKRRETDKNAIMTMVLREAGRNHRAKSSSISPVFVIDPTKDRCLHYEEIDHHSDEHPARLNIDSDIILSTPELDIRQDLIDCSIDICTPDVLSLWSDSFDYQSPRKHYLYGVLKDYELNGKTIHTYIIKEDYAARVRNLKAYDAVSKDIVSRWAYPLCPDTNLLPGHTYSLRKGNLYQEQGVTLARSCVLGRRTVIGRGTSIGDRTTVHSTILGRNCKIGKNVQLDGAYLWDNVVIGDGSDVRGAIIADGVVVGKNCSIAQGALLSYGVKIADGVKIESGKRITRSRPDGSVGTSDPEVVGEGGEGYEFIHGEDEEEEDDISVASSGLVYRMPGLSLSNASISTLSSEVSEGSWPRSGRSSFSDGEEQDNFHHDASVSVFDSLREGTSADVVQLELVSLRMTTNASDVQVRRAVVSSFMKYIQQLMEGGKGAGEAVKEVFTKYREVVDRTLFDRKKEVKKDQVDFLLQLQQDLVHRNKGASILLFTAKELYDLELVDEEAYEQWWDDERSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFU3</accession>
    <name>A0A1Q5UFU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFU3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFU3"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="35221" checksum="4CED28D8AEA39AA1" modified="2017-04-12" version="1">MPGKDYPSDLENGIDSRDAMTESGYVSGGGSSDDYVPEIVFTKPHLQFLNRQLQFLEPQDILRWCITSLPHLFQTTAFGLTGLVTLDMLSKLEVPRPQMVDLIFLDTLHHFPETLALVDKVRRRYPLNNVHVYKPLGADTAAEFESKYGSRLWEMDDQLYDWVAKVEPAQRAYREMNVHAVLTGRRRSQGGKRGDLDVIEVDEAGLIKINPMANWSFDQVKAYVKEHNVPYNELLDRGYKSVGDWHSTQPVADNEDERSGRWKGQQKTECGIHNPRSKYAQYLMEMERKRQEEALTQALQSSLASAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGG2</accession>
    <name>A0A1Q5UGG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGG2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="17765" checksum="ACBBA710CBFAD59D" modified="2017-04-12" version="1">MAEANDLSAIQEAKSLFHLSGFQKNQLRDAYIWIALRQHEDGSFVMSKSARDRLVPDWRELLDSKHNAPPPTTLDLRQSGTAMASSHDLPMNLNEIFDRLDNQDAIIKSLSRQVESKYTAIGQLTQCIHAQVASNQHVVAGLRQAERAMEGPLGGCRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHE6</accession>
    <name>A0A1Q5UHE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2561</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UHE6"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1896"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1324"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1459"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1329"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1473"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2083" mass="228223" checksum="A04A63CABA06BA81" modified="2017-04-12" version="1">MAVTVLPPSTMSESIKQAVRSTSTCSDATVLSLQTLLRGSSKVPEKPVRRNTKSSKEVPTTTIRAKTSRTTIKTRTTTETTLHIVEQDGPALSAQEKLVLATEVFNVTLKTLTDASKLSAPKRQPTNLDNVSIKSGRTNGTAVVDKGVYAAAECARLALATLRALKNDQQSPNEIPNMQLEQGACVLAGKFISLGLNEMACKELRSLKRRIQQHLDAKQAGRKVASNKDGGADEDTGKERMSDLLTFSNVANGESLYGLLVSYHANAMRLLVAEKKPSTTERLVPFLQISDQSSPAFIISAAMESGNLTNDKAALQLQLLSNTVLSLCANKSSPTDEPTSKDTLKPITNLSLQLLSLEIRCLGWKTSGHACDENKEMIDPLLRYLGGFSHRSKSIEKAEFVSIYKTITRIQSSMAEIKKQHQDAKDMNSTAKIMTILGQLAVDAGCLDESLKLFSKAIAPLFNSQSLPLATVRCKIASVYFQGLKGSKRFLDGALAAITDASGALGLQLRGSVNDLDELVVESAKLKKLALSWFGETITKPADSDSEKNQIASQIREYLQAFLRLLRRYVGRAPAEDSDEKEIEMFKARIAMSKSIILSGVDSAVAIGRLSIMSQRPPWEDILPILTDCHRLLTSIEATGGDGSDSSLAESIGAALVKLSNLFWSRYIKEKEAGQGYRELLPLLKQSTQVLSTCSPAHRTTAFAALKFERTAHLYLDGKKFDDSEQAFRCSLSEYVSAGTLEDIAKGNAGASPSMLNHDPQSPGFMLSRVLSAFLKTKLRKKAKSVSVYDDEELEPRRRGMLLEWQMGLLCDLHGYCASEDAFQSILSPVVTSTLNIYSADHHPIRHGRVILSALRFLLEHPNAMNADLTARLMEEGMEALKCDKGVGQDTDLAPFATHITNSLRVIIGFHQGKMDAGELDDTLSSWTSMVRQCPDSKSLLLCVTDTEYWVLQLKALVDYTEIHGLWKAQLSALELILRAAELLQSGDLSDGIVILARLVLQHCRLGHCQKAGDLLARGEKYLAQHEVSLLATISYKLARVEYLLETGEIEKAAATLSAARILYQKGQSSDELRNLTVLSKISWERLVADAAFVQSRLSTAQGSMTNALYFAKLSVRLNCRIWAKVEKLAQRKQDRSLPSNGGSDVEAVAEGVAKLDLSQNGLSPDTSVSYVQGAPFWPHLGSHHTCLLNLATLSAHHGLFQDAIYYGEQALKIDRSLDANVRLVAAQTQLGCYWILGGHLSEGQDLLAAASDSSKQLQTSVETVSLHMALASLYRVQGQHEKALRLLQEAEKAIASVTSSDAVSTSEGPNVAVLEEKMAKLQVRSSRRTASTTTAAAASPVRRTRATSSAAASRTTKKTSTSKTPMPEVQSNSLLRLKGDVLRQQADCLRALRDFDRSAQTLTEARQCAIARESKVSIEIGESEHLLADAIRHFASHAVYCVLPESTISLPSLKFPVKGGEEPTPQPAKPTASKRTRAPPKTTRAKAQKASEDFSIMLSKASECLTSVFTDATVLGSTLESHAASRLMSRISMLSHATTPGGPATWAQSPANMNEIGRVGAFARERLAIDFDRQLADFADPLLWPTTSPTTIEMNEDICTNFTENYVDILPQNWNVLSLSLSADQTEFVVSRLQKNRSPFLLRLPLRRGTSDDDEEEQFTFEDGKAEMQELIKLANQSAHAAKAQTNKQMKKDWWKNREALDSRMESLLQNIENVWFGGFRGIFSPLARDGDAFARFATSFQGILDKHLPSRQKGGKASSPRLTLHQNVVELFIGLRDLEAQEEPEDILMDLLYFVVDILQFQGERNAYDEIDFDMMVVDTLDALRGYHEAAREEIATHSPSHTVLVLDKALHLFPWESLPCLQGFPVCRVPSLECLRDRVLKFGTSHSGALIKRTSGSYLLNPTGDLRTTQATFEGDLSKLDSWTGMTNREPSEDEFRAYLETKDLFLYFGHGSGAQYIRGRTVKRLTKCAVAFLMGCSSGTLTEAGEYEPYGTPMNYLQAGSPALVATLWDVTDKDIDRFATSTFDTWGLVEKKGKTSSARSGDDVAGLDTAVAGARASCVLKYLNGAAPVVYGVPVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHU2</accession>
    <name>A0A1Q5UHU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Iron transport multicopper oxidase FET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2413</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass type I membrane protein</topology>
            <orientation evidence="7">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHU2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHU2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012004812" evidence="9">
        <location>
            <begin position="25"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="158"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="367"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP12055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="614" mass="68480" checksum="1AD2B7EEFFAE4AF7" modified="2017-04-12" version="1">MVTSVGGLLVRLVAALCLFQYVQAKTVTYDFNVTWVTANPDGLYDRKVVGINGQWPLPVIEVDKGDQLVVNMYNGLGTHSTSIHFHGMFQNGTNDMDGPSMVTQCPVVPGSSITYNFTVNQNGTYWYHCHTDYCYPDGYRQALIVHDNSSYFNDMYDEEYTITMSDWYHEMVEDITFIDKTNPTGAEPIPNAFLFNDTQNSSLAVEPGKTYLLRLANVGAFVAQYFYIEDHTFKIVEIDGVYTDPTEASILYIAVAQRYAILVTAKNSTEKNYPIVTVVDSELLDNIPSNLQLNHTNWLEYNKDADHPQATITVDTASDLDPFDDMALVPYDRMELLPEADVVLDLTVSMQNLDDGAGYAFLNDISYTRPKVPTLYTVLSSGNLSTNAEVYGDFTHSIVLEHNQVVEIILNNGDGGSHPFHFHGHNFQLVDRAPSYGRHFYDYADGDPLTYDPNNHTAFPRYPARRDTLVLPPQGYFVVRFVADNPGVWLFHCHIDWHLQQGLAMTFIEAPRQLQESLTIPKNHYDVCDAAGVKYVGNAAGNTQDYLDLSGQNKQIGWLPAGFTTKGIVAMVFSCVSAFLGMAFISVYGASGIKTAKKQETEQTEGDATASTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIZ7</accession>
    <name>A0A1Q5UIZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11532</name>
        <name evidence="8" type="ORF">PENSUB_1909</name>
        <name evidence="7" type="ORF">PENSUB_3121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000716">
        <property type="protein sequence ID" value="OKO94694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000282">
        <property type="protein sequence ID" value="OKP11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000208">
        <property type="protein sequence ID" value="OKP12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UIZ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="5">
        <location>
            <begin position="242"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="4">
        <location>
            <begin position="546"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="1433"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO94694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1915" mass="213797" checksum="5D07612669DE6A61" modified="2017-04-12" version="1">MLSSTTQGPFCTGCARPWLSTQFVTCDGCRRKAARWKVKARQRAAAAVEESRLSTMPPSRPLLRRLAPVLQAPLTSRESSDISNAVLQPAPRRLDPSTERSLVSQPPQAAGVKRCIPASLRATIKKQRTLDPRTFQDTLNQALGFLRDEVDARSAASNAFPPEVSSSHVRTSIARYEEEISAAANRDVCCSCGKLVPKSNIYNVHDMDPLLLPLRGALDTCGRHDNTWDLCSSCHASLNRNIIPKFSARNMVNVTMCQNYPPALKDLTLSEEYLIAKCHPLGVVLKLRPGGRSSPVNYHALRGHFIVIPQDPGPLLDILPGPDLTLHSLIKVFWLGARPPVDSDLSPFLAVRKAKVLAALQYLVQHNHLYHNITVNYRMIDDWSDDFIPPELRDNIICLDELDHHEREGYTVSLRQGNYENDLQAAQDSALDSNGGGPHITGSIFTDINGERQDPNVCALDALVSVVTNRPPPSREVMSARESERNTQLLDHRKIPVVSYTIRGEATLMDHWTDPHYFTAAFPTLFPAGIGGHLDERTIPVSLAAFADWALRHHSRRFARHKTFMYLLYDVIQLRKSSMGNGFLVKRQNWQSTMNDIASLTVNQLQDAAKTAAAGQKIEDLIIRRLLRNIETIGMQVPGSFAQKLRMRSEIRGLIARYGMPAFWITINPSDLRNPLVLILAGVEYSGVNLATANAAIREAAATSNPVAVAEFFNHVCKAILDGLFATNTGQTGILGDLSNHFAVVETNGRGMLHLHGLAWARGNLAFTTLRDRLLQDSDFAARMIRYLESIITQGVDESILHDPEVNLPSISPSATDNESDNDFHLRLSIDSNCVARKMQVHSKNHLATCFKYRKTASGKNACRFGMPRDLVPTSYIDKFGLIHLARNHAWINPWNPAIASCVRSNQDISWIPTVSKSLSLIYYITNYATKDDVSPWQIVAKAALLRHSIEKARKADPPTATDLRLREKGMGNFALRCFNTLSHDREISGVQVASVLLQLPTYYTVNYSFTRINLWWLRRYVRAIIRSDNLDRSRSSDSIAEEPCAYETGDTAPVSIFDNYKWRGPHLASLALFEYCMLVKTKNIRDAIADDADFDPSHPRYTTHVQRLARSPSQVATVTFSGQLTEFQAAEDAVLGGHPKTTAIINDMSEILLGLFVPWTHLVNLFRRYATQRDTCIQVWTAVEPTLPFHIRAFARNIELLRKSKEDCQADAKLWKSANGAADSFHHDVDELEPATFGSDSDDAEGSFRLQDETFNAETLIAAYHSITKAWHRESLVAGRRIPPLLRATTPTRNLDLQNLQPLDIPRTLAYETSGLQFVPPSTLQEWESRLKGFANLDREDTTEREVATSSLTLDDFDVQVEDNIFQPALTSFDMFPDIDDHQSRVGENPTGASLTSLVIEVIPLNQKQHLIVESVLSEALTWADHPYDSSQRKQTLLYVGGEGGTGKSQIVKAIEAGMSLVGRKHEVILMAPTGAAADNIGGNTYHTSLGISIDRSRATAMSSRVRRLWSRKTIMFVDEVSMMDLTMIGVIDNHCKIAKSLDRSSTDLFGGLPVVIFIGDFFQFPPVRGPALWKEPRTGAGAEENGRLLWHHFKQVIILDEQMRQSEDAPFRDLLSRARAGTLTEADRAVLNSKTITSLASPQLQDATTIVKLNSLRHQVNRVRIEQFARARCQNVYIFPALHSRTRSTGPINLRLRADDLLQQPDQGTKVPFPGLFLYTPNMPAVILTNICTLLGLVNGAAGTAVGIVVDQTAEFFQIDDLYIMCTKPPACILFKPDRPKPTAFQDLEPSILPVFPLERSITLKGYSVRRKQVPMCPAYCLTDYKVQGSTLVAAILDLKDDPTIRGQDRHRKYCSTYVQLSRLRSSKGLHLLQEVDMEDLRFGPDPRLLTEMQRLQALEKTTIAAWQEALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJW2</accession>
    <name>A0A1Q5UJW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJW2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJW2"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000008">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="5">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="4">
        <location>
            <begin position="109"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="431" mass="46787" checksum="F2F1D5E16EA028E4" modified="2017-04-12" version="1">MSSPKYEKPEVVSISPLLQRLAYPATADIRVSAEDIASAFALIFEDRLSDIQTAALLTLLHSTGKDRQADVIAKCSHRMREAACQIKKTELKKIVKARGRREGNYHGGLCDIVGTGGDSHSTFNVSTTSSIIASPLLMSAKHGNRAQTSFSGSADVLNAIQPIPPKISAVNATNVAKVYERTNYAFLFAPNFHPGMMYANPVRRGLGLRTIFNLMGPLANPIDWAIEARVVGVAYQSLGPVFVDALRQAGAKKALVVCGEEDMDEISCAGPTNCWRLSEYPNPAYKPSEGDDEDSSDGEEENPKTLVKVDTFQLHPSDFGLPVHPLTEVYGRKMPKDNAAKLMSILRNELPRDDPILEFVLMNVAGLLVTSGICEADTSNMGAGDDGKVITERGPGGGRWKEGLRRARWAIESGEALKSLEQFIAVTNELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK78</accession>
    <name>A0A1Q5UK78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0664 stress-induced protein C29B12.11c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK78"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK78"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="231" mass="24943" checksum="51C597E769BEA634" modified="2017-04-12" version="1">MSINWVMLDDQEGFVRLPNERLIYSSPPRTSLVLTPPSGYKGQETLSVQSSAGCIHLTNQRVVYLPAQKSDTFQSFSSPLLNVRDSHVSAPFFGPNVWTALIQPVAGGGISSSLPAVQIKVTFKEGGAFDFHTNFERIRERLEQAVENVSDGARGVRGVDLSAVHLEELPAYDGPGNTGPPPVASGAPVAPQHARQVSEGGPEPAEPPPCYEEVQSQSVAQELEERLRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULM8</accession>
    <name>A0A1Q5ULM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULM8"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="690" mass="77311" checksum="237F9BA47BCBBDDA" modified="2017-04-12" version="1">MSRALLRGAACQSCRHEILRSFLAVSGVPIPRFAPAVRPSFNSRAFSAVHSLRSDRPPISNPPDINYSPVEETKLEENNGEEKPTAHPTSRVPWYLQEEGQTTEERPIPGDHIPELPENSPEMLPILLEYTYKDLGLDQLKLFDLRGLEVPAALGANVIMIVGTARSVKHLNVSADRLCRWLRSKYKLSPYADGLLGRNELKIKLRRKAKRARAASHAGTTIDEKDDGITTGWICVNAGVVDKGAPKTDLKDAGFEGFGQLELGTNVVVQIFTEEKRADLDLDGLWQKTLERAERNRLREVPELESGVEHSTTSHSSFRGIGNSNGQRRSMHTVRRTTDSERSGLFAALAGKSTTSEPPGLGMSTDSLLRMLLSLPHENARAELGSGPDDYNSTVFLQLLYASLTDDMSARDIAVLRMKLYSIAVSRQHPAYSKDALFKAFTDLLRDGYELEDDLAFDTVAALLAPRSVRDHNNESVDYLPQEDIELALEVLNRLSLRGVPILNFKVFNMLYRVVDTPMKPPNESSLGYLPDSEQPILATSGKEWTKSQRLMLNRLSKLVSAAEVAFDEEEARQLMVTQFRCEDYDGFWRIWRQIPLKGTGRTQDDYRNLFQLHADLGEEGRARDCLSMWVPMMERESPAIELKGPIVTSVMHCLLVADPNIQNRVEDGSPSFFLGLWRRCQEALARPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM54</accession>
    <name>A0A1Q5UM54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM54"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="11802" checksum="B86EEE6F893C656A" modified="2017-04-12" version="1">MPWLRVADKSEERPKSMTRSLRSRRPAKVACKESSQSLLKRGQHVADERTSTPHGTVPRAKEGKNQVRGKECETHHDQPSFPRQNKRIQTFNSAIAGRAGKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMJ2</accession>
    <name>A0A1Q5UMJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="24176" checksum="194E5E483A9B3E34" modified="2017-04-12" version="1">MTTLVHYRILKNLDERNSQATVEQNKAYGFRSFASAKFLCCDPQRRSAQALMRVYIQIPHRTTEMDDKDTRGQQATAWTPQELAALLDLTEKRSNITPKLLGHKTGTQDPSGLVPGGFIIWLVWEIVPGLRLGDRDGAGPFWGLESNEREQIRISFLKALDYFIGHFSKTMKGKPIRSAEPAELIATFELALPDTPVRWKDWDKDTSRWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN15</accession>
    <name>A0A1Q5UN15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN15"/>
    <dbReference type="OrthoDB" id="4362149at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="264" mass="29201" checksum="41EE066992BF7630" modified="2017-04-12" version="1">MLFSQAVLYTVGIMASGVTGYKLDFYDFDGPPGSGCESDQLVWQDTWSSDTSSQCTPFKLSDKVKYIRIIKTDEIDNEQQVLFSSSDNCDPANAVRVQEGCFDISEAFPDAKSYQIVSRNIVKHPEKTVDSWWTPKGDAWSPIYIWTATVAGVTAVNAIRSSHGEHIAATVGRPLWAFVSSRFISSILIAQVFATGAVYLKQNWLSGNKDHRPCENAESTVNRLAKIIKKIAPVDEIEAIRATITLKGGRTMTISHQAVEEKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN59</accession>
    <name>A0A1Q5UN59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PARP-type zinc finger-containing protein C13F5.07c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN59"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="364" mass="39827" checksum="B1B8C820009C7853" modified="2017-04-12" version="1">MPTYRIEVAPSNRAGCKNKECQDQKIKITKGEIRFGTWVETEQFQSWNWRHWGCTTPLVLSHLVKAVFEKDNLTGDENFDKVDGYEELPEVYQETVRAALIQGHVDDDAWKGDPECNRPGMRGFRVAKKKAAAKKAATDDEAEETKPEATKEANDEPKKDGATKDEGAKPAKEVKKASRAKNKAADEKATKKAGDKVDVKADENGTQEEQKPAKAKRASRANKAATDVAAEKKTAEPATKAKRTSPRGKAATKQAADKEATDAETQPAKRRGRPAKSAAAAETSTKPAANGTKRKGSDDNEQDETAQKPKRTRKNAPAAEKKTEEAAPEKPKRGRKTAAVAEETEAQEAAPEKPKRGRKKATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNF9</accession>
    <name>A0A1Q5UNF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNF9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="274" mass="31302" checksum="E4858E82184F2E13" modified="2017-04-12" version="1">MNPIMNPLMNPYMNPYSIPYSNPYMNPYMDPISMGPIKGVPCEVCDRMFVTQAHADEHMVAVNHYRNRCDLCQQRCPSMMALLNHAMTHFHCTYNIYCPFCGSHFDKASALMGHLEEGKCDCAPGLEHHSIVWLVRNCDPAGAIVNTPFRWLLDKWIPTPPLGIVEPHMCFTCHLIFDTKEALEVHLKCPTHDPGSHRPRFYRCPNRTGGCHKKKFVSLTALFKHMESGACCTTNFHAVQRMQIQLMQAFWGWGMGAPMFRDAAGMPIPYTLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNW5</accession>
    <name>A0A1Q5UNW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SIT4-associating protein SAP190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000116">
        <property type="protein sequence ID" value="OKP14165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNW5"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1110" mass="121147" checksum="3AF4FC54E530B2BC" modified="2017-04-12" version="1">MFWRFGGYASISTIDTLLDKPDVTLEDLLDEPEIIQELKQHNTKLIEYLREDHVLKRLMDYVTAPSLVNDDDENDDDDSHEKHASPTHGESDAPTDQTDAEDKEEKAGKESDALKDVLDPEDLEKVEKARLKHAYVACEILSSETWSILESMMTNPAYLRDFWGFLRRPAPLDSLQASYFTKVNETLLDKKTEEMLEFLKSLDGIVAALLQHVDNPMVMDLLLKIISLEKAEGGQGTVDWLQSQDLIPNLLSFLAPEHPGSVQTSAGDFLKAIITISANATPNDQSCIGPNSLTRQLVSPERVQQLINAMLKGGNPLTVGVGIVIEVIRKNNSDYDPEQMGGPESMPTPYDPIYLGHLLRLFAQHIPDFMTLIQSSKHAVHDGTSLKSVDRGRLNSAWGASIEPLGFDRFKACELMAELLHCSNMGLLNEPGSEDYVRHRNEERDRLIREGVFNPHRDEQSGMDYNDTTADFTNGSVMDTGSPEALKARVVEDEGFEDVGASGVLVGKKGEEKESNLQSESQQPSESTSESAVETPKTDADANVPSSPKTPTTGLTDQVGEMEIGNESPQEQQASTETHKEDVSVTPQPEDVPPPLFAAKEPGSDSTAQAEGATEPTQESQPANDGGAEDLAEQYIQYDTDGRPVVGDFLKIMFVENKVVPTILGFFFRFPWNNFLHNVVYDVVQQVFNGPMERGYNRALAINVFEIGQITNAIVEGQKRSDEVQRTKQIRLGYMGHLTLVAEEVVKFSERHPPELLSRAVMESVLNPDWIDYVEQTLSETRERDNAILGGVRPDMAVGPRQTAMNTSTSNHGFNNNSSALADAGLNGGIGGSTFQGFEINQGSVSGGAFGGTSLLSGFASSSDDEDEEMEDQEDRDAGGADHGESENVSENSTSQPIPILPPPPAPLSMGPSRARRQLAARLAAQKQQASENAGVGEDGNAEGEGREWSSNPFIIAGIDDDAEGGNSAFPNTDFASNADQTFSSAFPESGFSPPDSLSTNSSDEEGDRAEGVRRRIRVPLEVEEDEDDEMGEMVGPSGSGMVVSDDEDEAIINESLGYSNLPGQTRYSGFRRPRAVSSHFDDDQDDSSDGEDDGLVEILVPGRKSSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP38</accession>
    <name>A0A1Q5UP38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_76</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP38"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="47114" checksum="8BB92E3172863326" modified="2017-04-12" version="1">MGSLGNNGVLPREGLPYFTPANNGGASTSPTSPETPTLFRPLQIRQLTLKNRIMVAPMCMYSCESDPSSPSVGALTDYHIAHLGHLALKGVGLVIIEATSVQANGRISPHDSGLWQQGTESEQFKGLKRVVDFVHSQGAKIAIQLAHAGRKASTMPPWVAAEAGKRSLRAEEAAGGWPHDVVGPSGGEEQIWAPGDAFWAPRELSTAEVEDVVKAFAQSAELAVKAGIDTIEIHGAHGYLLSQFLSPVTNKRTDKYGGSFENRTRLLREVAAAIRAIIPADMPLFLRISATEWLDGKFEGFWDMEESIKLAKILPDLGIDFLDVSSGGNHKNQTIEPHTNYQIDLAGRIRKEIRQAGQKTLVGAVGLITEAKAASQLVQGSDLDVEAHTAESMVAGSNAQADAVLLARQFLRQADWVYHAARTLGVKITVPKQLGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPL8</accession>
    <name>A0A1Q5UPL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_14185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPL8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38475" checksum="F9E4CFE3ACB4A196" modified="2017-04-12" version="1">MVAIIADQLAVYDGPLNSENAALLRPSDPSLPLEELRKRYDEDGYLFLKHVLPREDVLSARESYFSSLEPTGVLKPGTKPVEGVFDPAKSHEDYPSIGAGHIGGNGRPGGDRAAAFVDLALDAHYQDWYAEKFCNHPALYDFVAKFTDWGKNTLNLRRTLLRNNIPGSKPIGVHYDQIFLRYGDPTSVTAWVPMGDIKLNGGGLIYLEDGDRIGVEMEEAFFAKAKESGLTDEEARSAFNSNMMATGLLSEFPDGFAREHDRRWLVSAYEAGDVVLHKPHMIHASTINHDPDNVIRLATDLRFCDSSKPFDEVQSSRLCLLHYSVTDRTPPQRWMNHYSFNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPU5</accession>
    <name>A0A1Q5UPU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPU5"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012727943" description="PLC-like phosphodiesterase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="33551" checksum="51690887667FD998" modified="2017-04-12" version="1">MSSITKMTRALLSIMMLLQPVLGVPAAEMLPGADAATCNGRSEYCSRSYSNITFVASHDSAFVGELPQQNQNIDITAQLNMGIRYLQAQTHHSLLDKNVLELCHTSCLLEDAGTLESYLGTVKKFLDANTNEVVTILLTNGDSVDITEFGKTFASSGIDSYAFVPSSNPLPIGKWPTMSELISSEKRLVVFLDYGADTSKVNYILDEFAYYFETPYDVTDSSFSSCSIDRPSGASASGRMYIVNHFLDVDILGVKIPDRGAAGTTNAATGKGSIGAQAAVCEGLYSRAPNAVLLDFVDKGNAIQAQNQLNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ08</accession>
    <name>A0A1Q5UQ08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ08"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ08"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9418" checksum="964B369D0184E8BA" modified="2017-04-12" version="1">MSFINDAITHPVPILSSIEPHKLLSKEPLATAGSDDEKVAQRPLENGIRDGDPDVVLVDFEENDPKNPLHWSPMQKWMIVFVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQR4</accession>
    <name>A0A1Q5UQR4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">chanoclavine-I aldehyde reductase</fullName>
            <ecNumber evidence="5">1.3.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>dihydrochanoclavine-I aldehyde + NADP(+) = chanoclavine-I aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35947"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65032"/>
            <dbReference type="ChEBI" id="CHEBI:71487"/>
            <dbReference type="EC" id="1.3.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.100" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQR4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQR4"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="40622" checksum="F989E7EF833223D2" modified="2017-04-12" version="1">MTKLLTPLRVGRMELSNRIAMAPMTRFRVSDDHVPLPLVKEHYAQRASTPGTLLITEATIIAPQAGMYPNIPGIWNDAQIAAWKEVTDAVHAKGSYIYMQLWALGRVASADLLKASGFDLVSASDVPASSEAPVPRPLTEEEIQAYIQDYAQAARNAVAAGFDGVEIHGANGYLIDQFIQDVSNKRTDRWGGSVENRARFAIEVTRAVVDAIGADRTAIRFSPFSSFQGMRMQEPQPQFAYLARELAPLKLAYTHLVEGRVDGNADVESTDDLQFFLDAYKGAGPLVIAGGYQPESAKEAVDHKYKDHDVVIGFGRPFTSNPDLPFRIKENVPLVPHKRDVLYVPKDPKGYNDWEFSVEYKKAVEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQT8</accession>
    <name>A0A1Q5UQT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-alpha-acetyltransferase 38, NatC auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQT8"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="103" mass="11515" checksum="AD62D5A48A4EE6E7" modified="2017-04-12" version="1">MESEKAVEYLNGLIGRTLRIHATDGRMFVGLFKCTDAERNIILANSFEYRLPTTSAIHEAAAKETESWDKTEPKAATVKVNMSSRLIGLIVIPGRHITKIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR82</accession>
    <name>A0A1Q5UR82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR82"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="225" mass="24948" checksum="AFCF0FBEF16D1768" modified="2017-04-12" version="1">MTRIRQKTAQHLKESQNKAAFLTTFNEVDMSKIIKFRKKNKDRILEKHGVKLGFMGAMAKASVLALKEIPAVNASVENSDTIVYRDYVDLSVAASIPEGLVTPVLRNIESMSIVEIEKGISELVAKARDGKLTMEDLMGGSFTISNSGIWGSLFGTSIINMPQTAVLGTYGILDRPAAVNGRAEIRPMMYIALTYEHRILDGREAVRFLNTVNNNLERPESMLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMF9</accession>
    <name>A0A1Q5SMF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_13826</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMF9"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="16">
        <location>
            <begin position="219"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="844"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="956"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="969" mass="104377" checksum="084602E90CD8C846" modified="2017-04-12" version="1">MASMSTLPTPSRPSTNPPTGSLPPLPTPKPARKSTPAPDGTRSASPYQLSKLRTPSSPRPPSLARSPLSNSNSTSNLSAVRSVSSGRTPSSPDKTLRRTISIASFPQPPKAASRPSTAASSVSGIQGLTSSGSVKQQRSSRLSTGTTSSYRSSKTPSLLNGSADGKSVLAEARDPEASPSHSRSSSANGSCSTSATTFEDTEDAAGTGKGGKPKESKGNVIVSVRVRPDTSMGGETPRNHGEWGLDGRRSLISHRGKDGGDYYYDNVFTPQENNAKVYDAAAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTATSPGVIPLAITDIFSFIRETPHREFLLRVSYLEIYNEKIHDLLSTSVTNGVPAPQQEEIKLREDSKRGVYATPLKEEIVQSPTQLLRVIARGDHARRTSSTQFNARSSRSHAVVQIVVESRERVPAGDSQDKRSGIAPGGVRVSTLSLIDLAGSERAADDKERRTEGAHINKSLLTLGNIISKLSENKDKQGNPIDRDGRHLPYRDSKLTRLLQPALSGNSLVSILCTVQLVAGINAHSGETLNTLKFAARAKNSIVSHAKKAEEAYGSGGGDAGSRVLLERYRMEIQALRGQLDTQAKAQAEKELKWDEQQFEKEAQARHEEQVLEMQLARTALKERIEHLNRLILSSKSTGVNNHGSLSSAFGRLSRMSSTDAGTRSLRSSASQSTLGAAHSIRPISFMSVNSNDPSGMSFANGSFSNEDDEDMGEFGDGKASLQRQVTALQADLSDKNRYISTLERRLLQARRSSHSRMSVGVKSNAPSTTTISEHPDMMTLLREKDMEINELRIQLDDKDRMLAALRSAARHRDLAAVTGDSQSPELKVKVDSSASGPSSPRLPPPGDVSDKNTSPSRHAVPGKSGEREEDRRKNMDEVSRMLDEMIQGRVESGHLDRNSLGHFKRVSGDSRRGSSSAEVPGLTPTPSLPVEPIPGSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMT8</accession>
    <name>A0A1Q5SMT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000774">
        <property type="protein sequence ID" value="OKO89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="224"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="610" mass="70161" checksum="B7CBB954BA0B26FA" modified="2017-04-12" version="1">MANSYSEEEDRIISALEAYRSGKNRNLSALAREYGVPYQRLRRRSLGTPSKIGNQNRPRLLTKAQEGAILSTIDSLSRFNIKLNGKDIEDLANLLLWRQYERDHPDATAPKTSAILPRLAKAQNIPSELKLVNHQWAYSFIKRIDPSLLPIADEQIESERAKVSAAMMQHWFDGLEPVIKQIKHCNIYNFDETGFILGQQPSRTRSIGRRRARAEVDERESLTSIECISASGFALPPFFIFRGSVLLERWFDESLDPDWVVSVAKTGYVNSDLAFEWLQHFDKHTINRAEKNEPRLLLFDGHTTHLTAEFLEYCGQAKILPFCFISHATHLVQPLDGDTFLTYKTKFRSWNRMVSQWGGDPTDKSVFLRGIREIRDETFTPHIIRGSFRKRGIYPFNPDLVVKPLTEREEREFVPLTGFDGILSDNARGIQPQPPQGDRVTSPALSSSSIEQPETPRSVKKCWQKLRKAIDSPLDRPGRVEKVERRWTRLETKTVTKYEEVIIQHNLLAKATKVRSSYTTTNRTKRQITKVKVLTTKDANARIAMRTEKENQQWVQRVRRENAKKLAEEEAAAVKLAELRRKALAGSDIDRLFEPFDIFEDREGDSSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNH6</accession>
    <name>A0A1Q5SNH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNH6"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF8">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34775" checksum="097E97A6D05EE081" modified="2017-04-12" version="1">MATSPQPEMTKAIPAPDTDARAPAGDDWAGLTDPAERRRRQNRINQRAHRMRQRQRMRNNKDIHPKSVVASTSSSSSSSSSSSSSSSSPSSSTAIVRKQSSSSPSDQSPRESGCLTSKATRILLSQFAESAYQSYTQGSPTSEHLLMLTQVNVFRAFGHIVQVLGWNFDEMDDDAISPFAIPSAAQASTPPDYSDMPLSLRPTRVQRTTPHHPWLDFFPLPKMRDNMIQAGNEWDDEALCRDIMGFWEPSSTAAPGLLVWGEPWDPRNWELTETFLKKWQWIVRGCPEIMESTNSWRAKRGEKLIFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPP4</accession>
    <name>A0A1Q5SPP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000763">
        <property type="protein sequence ID" value="OKO89997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPP4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPP4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="109" mass="12766" checksum="954473741673CC3D" modified="2017-04-12" version="1">MAGRTATRTPEPPDRDEHEESPPRLSRPRRTTRPPSNYARDQEIDNNQRTTRSQLRKKTQDRPVTEDNAVTSDDSATESEDLNTATLVKELIKLRREIRRRDELQKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SR42</accession>
    <name>A0A1Q5SR42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SR42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SR42"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="379" mass="41558" checksum="E06B6FC30502E574" modified="2017-04-12" version="1">MDQTTHWVHTWAAMPMRSEPDKLPPKEFTRDTIIFHNTTIRQTVKITLGTEKLFRLRLSNAFGTDDLTVNQITVALAKNNLSGTTKIEAHTLQNVTFDGGLVTTTIVGGAQAVSDPIDFGFPLSPNTVLSISLFLENGQYSKTGITSHPGSRTTSFCSLGNYVSEPELTDPSVQEVEHCWPDLLFTRLQSNPATASISILNQAAGGNRILADGIGPNVLSRLDRDVLSQSGVKYVLIFEGVNDIGTAEANEESQAMIGDRIIAGYRQVATRVHAHGISIFAATITPFGLRKEEHVVDAEAEGITGYANPIREPTRQRVNEWIRSSGVFDAVIDFDQVLKDEEESGVLRREFDSGDRLHPNTLAFKALADFFPLEVFDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRA7</accession>
    <name>A0A1Q5SRA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRA7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="15930" checksum="344762D7B0DE924D" modified="2017-04-12" version="1">MGYDVADYRSIHAPYGTVEDVQELIDELHSHDMRILMDLVVNHTSDQHVWFKESRSSKSNLKRAWYIWRDPKYDAQGNRKEPNNWKSIFGGSAWAFNEPTGQYYLDLFLPSQPISTGRMQRCVKLLTMKCVSGSIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRK0</accession>
    <name>A0A1Q5SRK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRK0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRK0"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="71"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="431" mass="46802" checksum="B82EC2C7A385A728" modified="2017-04-12" version="1">MDLSRIIKPWKLQPPKTLVFVNATIIDPVEGQLIHNATVRTSGGKIVQIDTTGSETAKEGSEDIIDLSGKYLCPGLIDSHVHIAVCPGEADLRAYKDMTERISLLRQPHVLKTMLERGFTSIRDCGGASLAMKEAIEEGVVPGPRLFMAGFALSQTGGHGDMRSSHEDQLCCGGSISGISRIVDGPAECYKFARDELRKGADFIKIMGGGGVASPTDRIDHVQFSDEEIKAIVTVAQNAGTYVTSHSYTPQAIQQAIKLGVRGIEHGNLIDLETAQLMAEKKAFLTPTLIAHVMSKQMNFLPQDGAAKNDEVLEKGLRAMKMAVDAGVTVCFGTDLLGPMHFAQSKEFSVRSKVLTPIQILQSATINAARLLMQEDRLGQIREGFAADLLILNANPLEDITILDRNEQSILGVVKDGRVMTSRWEKLKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRT1</accession>
    <name>A0A1Q5SRT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Beta-hexosaminidase</fullName>
            <ecNumber evidence="3 9">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13353</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3 9"/>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRT1"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384532" description="Beta-hexosaminidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="12">
        <location>
            <begin position="182"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="601" mass="66769" checksum="941F37107DDDBC17" modified="2017-04-12" version="1">MKCATILGALAFLASAASAVKVNPLPAPRNITWGSSGPIPIKRISLRASDSHGHNHAVVDDAWDRTWSAITDLQWVPAATEAPIPTFEPFPTHSAKKKRGTTATEIRSVQLSVVDGDADLQHGVDESYTLEVTATGGTVKITSQTVWGAVHAFTTLQQLIISDGRGGLIIEQPVKIQDAPLYPHRGVMVDTGRNFISVSKILEQIDGMALSKLNVLHWHLDDTQSWPMQIRSYPQMTKDAYSSREIYSEADMRRVIAYARARGVRVIPEVDMPGHSSSGWKQVDPKVVTCTNSWWSNDDWSKHTAVEPNPGQLDIIYNKTYEVVGNVYKDLSAIFTDNWFHVGGDELQSQCFNFSSYINEWFAEDPSRTYNDLSQYWLDHAMPIFRGTGGPKRRLMMWEDIFINTDAAHTVPRDIVLQSWNNGLTNIKNLTASGFDVVVSSSDFLYLDCGFAGFVTNDPRYDVMTNPGGDVTFNFGGGGGSWCAPYKSWQRIYDYDFTANLTASEAKHVLGAEAPLWSEQVDDVTISSKMWPRAAALGELTWSGNRDAAGNKRTTQLTQRLLNFREYLVANGVMAANLVPKYCLQHPHACDLYYNQTAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SU85</accession>
    <name>A0A1Q5SU85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">PENSUB_12984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SU85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SU85"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="312"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO91577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="569" mass="62309" checksum="7C93CC0F1C03ECAC" modified="2017-04-12" version="1">MAFNFNWSPLMADAGFYTRAQDLLTAALNKSPKPPIIVDDIIVTELNLGSMPPNLEILEIGDLAEDRFRGIFKMSYSGDAFLTLKTRVQANPLNTYLLTRPSFASPKPLAAATPLTIPLQITLSDFKLSGFVILVFSKQKGITVVFRNDPLESLKVSSTFDSIPFVRDFLQKEIEAQLRILFMDELPAIIHRLSLRLWVPEYRAGEDIKTQNDNTESTAEGPGQDPLASPPQDPVDAMGNALNESQIASLSLDSSVETHSLFSQKNLLRLAALTDSQRTLSLFTPSIQEVVYRAWTSPVDPSEAAASIASPLSPTLSRTHSQIGSMASSIHETASVTSSHSRPSLSSAHSFSSYGLNLGTGRHSKAHSRRRKKRVVDLRRPKTTDDAMSVSDDSAMTESSSPPSIYSAPLPVVNEQSDDPVTPPLSPETDSHLPIIPERYRTSVSRPTLRRSTLTRDNEDPSYSVETIRPSKVEDVEATPRATVRGGYQNEKAEAGPSSATARPPLPATILPFTKEDNPTGDSVDSLLVERLAGEIARRMREEKLMANNACSNFWSRAQDDAPPPAYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXM1</accession>
    <name>A0A1Q5SXM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXM1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="68" mass="7683" checksum="6908751636F53995" modified="2017-04-12" version="1">MAPVSLLIASLNFTQAEILKAGLIQFAVDRSPILSLSEFFTKVLPEFFTKVLHEWLAKVLEWLTHPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYC0</accession>
    <name>A0A1Q5SYC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000738">
        <property type="protein sequence ID" value="OKO92886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYC0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8641" checksum="40C88D551810B5C9" modified="2017-04-12" version="1">MPPGRDSVPLELLERTVRYVTVSMLRTDSVLWCISSAESATLSGLNIGAGMQYLELHSLTRSDEVSLIHCPFCLGDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T043</accession>
    <name>A0A1Q5T043_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T043"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="31027" checksum="FCEA2857BD056B70" modified="2017-04-12" version="1">MKGQQYRLQYIPQEGFLRYSGAYWMSHVKRSHNLGGEWIRKVVTLCEAGSESAYWISYHEGYSFWELCRNHNTARQQSLFWVAHWALTEAVIFLVDDAGAEVSARPYQYQITQPIVETVPWNEKNGKALTRVLLDQRGVEIEITEEVVWNATLNEESGEEILNLLLDRRGAELKITQKVLRGTMTNLRDGSRLMRLLLNRGVEIKITDKVYEHAASYWHDKDEMMQLLRNRRAADLNEADVKEADVKQADLRAAEPRKGWLSYFFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0E0</accession>
    <name>A0A1Q5T0E0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0E0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0E0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="829" mass="92318" checksum="6706BA78263D0F34" modified="2017-04-12" version="1">MSFHSASPEGGLNSPSASENSPNSARSGVLATAPRPVSDIASARSCVTCRRRKVRCNKRSPCSNCVKAGVDCIFPPPGRAPRKSKRPPDAELLSRLRRLEGVIEHLSGQNAENPASAASASSISPTQPSATFPPLPPAPPSTVTAPSTASSSAAPPPAQDSGCPFENDDPKKLAPKKFENEFGRLVIDEGRSRYVSNRLWASLGDEIEELQDILDHSSSDEEDVPSPESSHSGSHDGFLFGFYSLSHSLREFHPNLPKVSMFWEAYRENVAPLITIVHKGTARTLLVEAAQNPDSLDKNNEALVFAIYLSAIVSLGPEQCMARFGEERSTLVKRYRFAVEQALSRAGLLNTQSLVLIQAAVLFLICVRREDDSKFVWSMTSVILRLAQGLGLHRDGTNFALKPYETEMRRRLWWHICLMDVRASEDHGTDPQINESMYDTRLPLNINDDDITPEMTEAPIEREGVTDVTFCLIRCEITSALRRANYSCPGTRFRLGETVPGIERCERMIQIISNRVEERYIKHCDMNIPMHWATATVGRLILAKLWLVVHHPMTRKDRVLNVSQATRESLFLTAIEVLEFGRLLETDPKTAKWGWLFRTNMQWHGVAFVLSEVCVRPICPVTDRAWNAVQGLYSDWERQATHKKGMLWRPLAALMKRAASTRAKQQEELLTNFGPNPAAAGYKPDPTDFALTHHHTLPQIHMPNNSPLPSSIPPSQTQQLQEKPDLNIDLNQGPWETLQSIFPNTNFLAPVTLDNPPMQEPVSAVNVPTGLSSFTSPVNNNGFTSQVNIPETATLNWDEWDQVMRDFQMDVENDGSDLGKGTHVTEWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T119</accession>
    <name>A0A1Q5T119_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T119"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T119"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="241"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO93890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="462" mass="51677" checksum="57DE028718E08BA2" modified="2017-04-12" version="1">MSTLEDLDDLERETRDKKQDQGDEDGKKPSGDGDAEMQDAEKKEDEEELLDEEILHSSTADIVKRRRMLENEMRIMKSEFQRLTHEQSTMREKVKDNQEKIENNRQLPYLVGNVVELLDLDVEAEAAEEGANIDLDATRVGKSAVIKTSTRQTIFLPLIGLVDHEKLKPADLIGVNKDSYLILDTLPAEYDNRVKAMEVDEKPTEKYTDIGGLDKQIEEIVEAIVWPMKEAERFKKIGIKAPKGALMYGPPGTGKTLLARACAAETNATFLKLAGPQLVQMFIGDGAKLVRDCFALAKEKAPSIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFASDDRIKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARANILQIHSRKMSVEDSVNWAELARSTDEFGGAQLKAVCVEAGMIALRKGMSKVGHENYVDAISEVQAKKRDTNMGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1B0</accession>
    <name>A0A1Q5T1B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000721">
        <property type="protein sequence ID" value="OKO94068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1B0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11258" checksum="22F382E928EBEAAB" modified="2017-04-12" version="1">MVEELLVRSLASMFKAHPTSRTAEVRFMRQIRRRLRYLPHSIQLKPYPGSILVSWEDNKTESVRKLGPGGPDYHIVLHEDNYANSGTALLHDEAGKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1C0</accession>
    <name>A0A1Q5T1C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heavy metal tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000721">
        <property type="protein sequence ID" value="OKO94071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1C0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1C0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="103"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="422"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="617" mass="69631" checksum="0A3F5B35A0FA538F" modified="2017-04-12" version="1" fragment="single">VRIVTLVSQVLIYTSKSGLLASKSESLHDQFNEATETTRLLDSSGGNHMNSQIPEPVHDGSQDPSIHRTTFPFGNKWKYLMGYSIFLPYMWPSKSHGLKLVRLACLFLLVVQRINNVMTPILVGVIITALANQQEAHAFYVVWPQITLYVFSRWLQTGLSSLRSALWIPVSQYSRMELSTAAFEHVHNLGLDFHRNKKTGEVLSALNKGKSVTGLLEQVVFEFIPTLLDLFIAIGYFLIAFDAYYALVVGISSFGYIYVTIRMGLWRAQTRREMVNASRYEDAVKNESVVAYETVKLFNAEQHEFHRYRTAVRDYQKTEYYSSLRGTVLNTVQNTVLMTGLLCTCFIAAYQVSTVQQPVGLFVTLLMYMAQPQGPLGYLGSFYASIQSSLINAERILELFREQSTVVDSKLATPLVACKGEIRFQNVQFFYDDRKVLFNGLTFTCKPGTTTALVGESGVGKSTIFQILYRFYNPADGSVHVDGYDVRDLTGDSIRKHVSIVPQHLALFNESLMYNLNGGEKQRVAIARTILKNTRIILLDEATSALDAGSETFIQRSLKAFSYDRTILVIAHRLSTITAADCILVLHEGRVVERGTHAELLELNGRYAEMWRNHTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1E3</accession>
    <name>A0A1Q5T1E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1E3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1E3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="225" mass="23939" checksum="76CB08F7A4C788F9" modified="2017-04-12" version="1">MQGGPKSCRSVGAETRRQLEELNVEWLQIAQASTNTRAAMQEISFHLALAAATNCAWWWDTTGYFPGEPGKPGPSSAEDDFPISLWVDLGSTTSPSKADFAKLFSADEEGFDSSTTTTTTHTTTASAPTATADDTCKESYKFFWDHFEIHGKNFDPSKFGKDGSGLKKQIGGCGALSGWHFETDTSGGWQWHAKGNLPIGSKDCVGRAVVSAGGEGPDGCKGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T262</accession>
    <name>A0A1Q5T262_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl reductase LovC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T262"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T262"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="11"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO94314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="38101" checksum="BACCE9D32E4AEEDA" modified="2017-04-12" version="1">MASAVMKALVGDESSGYRLADDFEIPVPGPGMMLCRVHAVALSPYDAKIVDYSNTPGAVGGCDFSGIVVRVGEGVTRFKEGHRVLAVTFGLNAADKTAGAFAEYALATEDLSCHVPDNLTFEQACSMGLGIATAGLALFQAPGLHLQMPRPKPTSDDENMPSFVLVSGGATGTGTMATQLLKIAGYTPIVTCSPANNALCESYGAAACFDYRSSTCGADIREYTANNLASVFDCVTDAPTMRMCYEAIGSSGGTYVALEAPTQVVKYTRRDVRADWLMTPTITGTPVVIPGTYGRPSTPEHRIFGAELFLLAEKLLQEGGIKNHPLDIREGGLERIPTYVNDLRVGNVRGKRMIVPLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T281</accession>
    <name>A0A1Q5T281_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T281"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11422" checksum="9001167FED86C9B8" modified="2017-04-12" version="1">MDEIRLCQDLVDELELEYVNEDRATIISTTPEKIFQNTTIALWARTYLGTKEINLGLPSLKTWLENLALCGPGRSGMYEGVTYKFVKREFLHLFYEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Q4</accession>
    <name>A0A1Q5T2Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Q4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Q4"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="353" mass="37901" checksum="CBBAE1C5A2FBC5A6" modified="2017-04-12" version="1">MSTYKQIIYTTTPDPAINPSLTNGTFSIKTVPKPTNVPADQLLVRTHYLSLDPAMRQWLTAKRSYIAPVELGAVMRGQGIAQIITVGADLTSKFTPGDWVVAYSGWQEYAVLGAKEVEKVVLPPGGRPTDAMSVLGMTGLTAYFGMTEVGFPKAGETVVVSGAAGATGMVAGQIAKIKGAKRVVGLAGSKDKCEFLVKELGFDVAINYKDADWKKQLKEATPEYIDVFFDNTGGEILDACLARAARDSRFVICGAISQYNSAKPQGPTSFMTVISQRVTMKGFIVFDYAKKYGTALQELASWLSQGKLKRKEHIVPGGIEGAPQALVDLYKGVNTGKMMVEVAPVSEAIKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4S2</accession>
    <name>A0A1Q5T4S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000705">
        <property type="protein sequence ID" value="OKO95227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4S2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4S2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="156" mass="17353" checksum="B3C4D5E25F26DBC0" modified="2017-04-12" version="1">MSSPKRPLSSPTSQSKRQRVDANADADMHEQPSKRAPGKSTSGPTASASLSTEFEYILKHHISLAAPTVSLLDWYLCLWNCYIVDSALKIRLEEEQGQLQRSIAWLTAECDILLQCCNDQALELSGRRKAVAALNDGIFEALKASEKRAYRMVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6C6</accession>
    <name>A0A1Q5T6C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6C6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6C6"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="53"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="297" mass="33232" checksum="DBB9F10D12A33188" modified="2017-04-12" version="1">MASRLSWQSLRARPALFSTIAVAGIGAYYGTRSFLLPTGHAESPESPKVFGGFGFTTLRLQDVKVVNHNTKRLVFDFPDEHATSGLTLTSALLTYSWPKGQWFPVLRPYTPISDLNQTGSVELMVKHYPNGKASTHLHSLEPGDMLTFAATLKGFPWTPNKYSQVYLIAGGAGITPIYQLIQGILNNPNDQTKINLVFGVNTEQDLLLHDELEQYKKRFPSRFNYIYTVSHPKEEGSSWRKGYVTEELLRDVMRGRDKDTHVFLCGPPGMEDALVGSRKSPGVLGRLGFSKDQIYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6W8</accession>
    <name>A0A1Q5T6W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxynicotinate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6W8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6W8"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="46"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="52020" checksum="3F6F0F56E6AEC4E8" modified="2017-04-12" version="1">MGSTSQSEEGLSGCSLKTPSYPSNCLAFLNSPPTVQPSQTAHVRLNIIIVGAGLGGLATAIALASTGHTVTIYEQAAELGEVGAGIQIPSNSTRLLSRLGLDPYLEKYVTEPETISFRRWESGDIIGLTKLIPNFRETFGAPYYVIHRANFHSALHERALDLGVSVRLAARVVKYDSQGGSITLADGTSASADLIVAADGVKSIARREVDGSDRPPFERTGFAAYRATVDVHKMKADPEISWLLDRPSLNIWIGNQRHVMTYTIGAGKSFNMVLSHPDNTDPSTWDQSTALSDMKREFQGWDPRLEKIITMIETTIKWPLVSGTPLPRWTTGRLVILGDAAHAMLPYMSQGAAMAVEDGLALSRTLSKLTHLSNLPHALQIFEKVRIPRATKMQEASLLNGKLWHFPDGPLQQARDKAMRPETVGETFAHSPNQWSDPATQMWAYGYDAEGEVERVWKEETQEGKERGSVRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9X0</accession>
    <name>A0A1Q5T9X0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000696">
        <property type="protein sequence ID" value="OKO96981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9X0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9X0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="127"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="681" mass="76058" checksum="84FA2C874E8FC321" modified="2017-04-12" version="1">MREFRAYVPEERVAKSDFQELIGRSRYMERILKRTIEGIRLDTKSLAKLADALDVDGDSAGVVGSDAQEVEGLVMDDEACTMDPANEPKMGWDFPRAHQLRPGRDHLAAAISCCPPRPIAEFLARNFFKYAETHYFFIGRSWFFERMNLLYGDPSTFAKKGGEVIISILLTVFAIGSQYAHLESSTQNSTGTSSQNFSEEDIGATFYQQAIRLLPEIIELSSLESVQACLLFGYYALPVDTSGLGYIYINLAIRLGMQNGMHRKCKNDAFSATMVEARNRVWWTAYLLERTDVDAALPIYRSDLALDDTRTSVARAEASIQLIHFLEDIFRDVSNLRTCHKQQISKIISHLLTSKAALKEWWSSLPQEIVSSSLQPIAQLRSVMHLQLEYCLVRMFIGRPFLLKKNISESLNNSPADSEPSVADRNATSDSTSFKYSLSRKDLIDDCIEAATEALGILQELRDSGSGLARASYIEYSSCRASLLVLIAYSIQNFSEQFRNLLYKGLDMIREMSAAGESAQSEVSLIETLERALARLHAGVQQSQQGSMTLSERPISDYETFKHWGARLRKGDMLEAANFAADSSPAQPDDVGPLTGQSSGFYSHSYGRIMDMDCSQASLSMSDRDMGMLGALDPIIEIPLFGAENTSPSAAWPTWTETQVLEQFLMNPEYGAAQSMDMNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB66</accession>
    <name>A0A1Q5TB66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB66"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="31724" checksum="48346F4885CC351E" modified="2017-04-12" version="1">MSTLSSPRPSIASSRAHSPTPASSRPSLDALNTNLPGGLSASSTPSTARAISPNPRRNRSALRDYYNLKPPGADSGSPGGSFRSRSVPRNTDAGDISNPSTLASGTELDNADFDPQRYVDHLLSTSSLSTILKAENTLVGDIRTLDGERKALVYDNYSKLIRAVETIGKMRKSMDERGAPLTMTKTLGPAIAFVAETAGGLIKEGEEQRRRIKEEREAEPPQPKKAEKETVRWVLAAPERLEKLLVEEKQTEAEKDWEEVQRLLDAWGEVKGVAEVRAACEKVMEKPSNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBT7</accession>
    <name>A0A1Q5TBT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RuvB-like helicase</fullName>
            <ecNumber evidence="18">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_9978</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="18"/>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBT7"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 18 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="12 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 18" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="68"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKO97687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="469" mass="51311" checksum="3486A75B3024B733" modified="2017-04-12" version="1">MAAPISTVAESKELRGLNLIAAHSHIRGLGVDMDSLQPRGTSQGLVGQEKARKAAAVILQMVKDGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGSDVPFTMLASSEIFSMEMSKTEALTQAFRKSIGVRIKEESEIIEGEVVEIQIDRSVTGGNKQGKLTIKTTDMETIYDMGTKMIDSMTKERVMAGDVISIDKSSGKITKLGRSYARSRDYDAMGADTKFVQCPEGELQVRKEIVHTVSLHEIDVINSRSQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIIPGVLFIDEVHMLDIECFSYINRALEAELAPIVIMASNRGQAKIRGTTYTSPHGLPLDFLDRVVIVSTQPYSAEEIRQILAIRAQEEEIDVSPDALALLTKIGQESNLRYASNIITTSHLLSQKRKAKEVSIDDVQRSFRLFYDPGRSVKFVSQYEQRFIGDQGAVNFTAAANGDAMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC66</accession>
    <name>A0A1Q5TC66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC66"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF4">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="374"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="511"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="74447" checksum="30DD4686FD243128" modified="2017-04-12" version="1">MGVLCQYNEKEGLSPLSTQTELVGNDGRPAQIPASPSTTTRYPVPAKAHFSTLMSHRKSTVVNLAYLYPKTMAYRLQTSWLDTAIVDPCLFHAVFFGTSSYIDITQGAPASSITLYHKTQVIRQVQRAITECNDKDIPTSAVAATLYLFYHTKLNGELTEARAHERGMDAILRHYQYEKPDPNTFFGYLLIASNQETQGDVLRLKNAVTSSDEEFWFMQGPEVFRWILLIGAAAASSSSLRAWFIVRSFNFCAVVEPQEVDAFVAATDHLVSLFNHSPFEVENVYIQDISHQFGKNSSKNENTLFISDFLSFAIMANSHLPNCHPDITPDWQDLGYPRTSFEQAIALEPVQEEQGCYAGFAPKDWCTPHGRDLFLHGGYIAGLLIRASRSYFHDSHGKLNQPDPIHMNLHFLQLIPPGAFHIQLQAIKLGRRHSTIQAKIVSPDTRNPVLYSLAVLTMGNLKIKSGVNLNLPPIPIPDRERECARWTNAALYKFHPCTSSIRYYNPKGGESLLWSPKRGRNWRDQWGKLDSGENFRLEHLGVMADLVRGRYTAPCTFKTLYLHGQIPPIHMNYLKNELAAVLDYEYRTMSMDFDFRADPAAKMEWILNRATTYKLEGGRFDMHIQMVDENGNLVATVHQSNLIFENGRRKAPKSKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCF0</accession>
    <name>A0A1Q5TCF0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCF0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="10155" checksum="5CBF179BD1BE4884" modified="2017-04-12" version="1">MLRASKGVGPAPGASGGPLKNLLSNRERVLNVNHGAHDLLKELGRSQNAKPAPKVVNFLRQVEELTKDLLSTPLTDWQHELEALRKDLKQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCU1</accession>
    <name>A0A1Q5TCU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mesaconyl-C(4)-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCU1"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="39321" checksum="40887935303992FB" modified="2017-04-12" version="1">MRPQFLSRTRQFNAPRTFTTSARFFSAEPPAASSIASSFLSRFQTPGPQTRTQTLDANQLQLLTLTLNRPSLYPGSPSLSNNAPPLDTPVPPGYHLVYFTPAFLEGELGADGTDTSYNPESPFTRRMWAGGEVLWPRGGDGKPNFLRVGQEVRETTRVLSAESKVVKKTGEDMIVVGVEKQFFNEHGVAIIDRRNWVFRKALPTPSLLTPLNTATPSTSHLTEASASIISTEGNTHSKTFVQSPVTLFRFSALTFNPHKIHYSLPWARDVEGHRDIVVHGPLNLISILDLWRDIKGEGKESGLEAMELVPRSISYRATSPLYAGDEYNIVLEEDGNLAKVNILGPGGNVSMKAEIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCW8</accession>
    <name>A0A1Q5TCW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCW8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="43310" checksum="27138CC819BB7772" modified="2017-04-12" version="1">MEQQSGRAQATLLFAAILRDIFNHPDWSQLHNFFSKRYPAGQDSEDVNMRTLNPPKELSTWKKPTVVDFMTDPSSVGLPKDLATLLATAGRTSRARLMGPDPQPCAIGPAISVACGAGAYMDLTYAGQPPGKYEKMTYAYGELYGWKKDKFEVIAGAIPTTKKGGRDRYWAEWAILWSVISEWAYEHDSTALQLGHLSTHSFKYRLSPEEDRSFDHFGKIPRKYLKTDAIAAADAIHDVFKQLAQEPRLFQGVEWDFLDIGVPVEVREAFHARFGEKGPDHNENRARLLQSVPGPGRDSLAYGDSLLYEEVSPMALRRCPDSFFGASWESWLLSIEGGDVVVVETLFQVSLSQDPWRMFGLSHLALGTLGSDVVVTASLEHQNHRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDK7</accession>
    <name>A0A1Q5TDK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_9403</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDK7"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="288"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO98305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="449" mass="50047" checksum="31950EC3770C8F24" modified="2017-04-12" version="1">MPVTNFSHPDPYTYQTGFDSYHESEAIEGALPVGHNSPQKAPYGLYAEKLSGTAFTAPRHENKQTWVYRILPAAAHANFVAEDADSYHTRMTTETHKLHHIPNQLRWNPFDLDEKVDWVHGLHLVAGSGDPTLKQGLGILLYAAGKDMGKEAFYSADGDFLIVPQHGVLDIQTELGRIILRPNEIAVIPRGVRYRVTLPAGPVRGYICELYQGHYQLPELGPIGSNGLANARDFQAPVAAFEDEEEPAEYRLYSKFNNTLFSARQNHTPFDVVAWHGNYYPYKYDLGRFNTIGSVSFDHPDPSIYTVLTGPSDHVGTAIADFVIFPPRWLVAENTFRPPWYHRNTMSEFMGLICGGYDAKTGGGFQPAGASLHNVMSAHGPDSDAFEGASNAELKPNKVGDGSMAFMFESSLMVGVSEWGLKTCEKVQEEYNQHSWEPLKRHFKNPNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDL1</accession>
    <name>A0A1Q5TDL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDL1"/>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="61799" checksum="D78A9765BA6D0FAB" modified="2017-04-12" version="1">MTESVPRDTPEQSQADDQHDQESASKSAINPALKDRRCQYCGQAFTSSSLGRHLDQFLFKKKPDGIHDVEEIRRIRSGITRRQARTSSGKRDGSPDQAERKGPPGTNAAGSSASKSRDAPVRMMFNTPTWHATGVINDIPNPSRTADGPRIAPAQSRAGSLQLPDFASRGATANNPDTMKALELALREVLDNIKAATSRVRPRLSPFDFEIQAQTFPSLCLQLLPPPPSLFASHPFSSPTSFPLQPPGREHLDVVRQALRSKVAQWRSDQLLSKDSAVRPGNVGATLDNSMIYRTAHQHEEMSIRHLELAFNHWNTLPHETRREAWQLEITRAFARELEKRKSVDEQLARVQQEANQLRAQVERLGSCQWPREFALFPPDTLPISRDVARELDEKGSQISPESSRWDFDSVVSKWKRVVMHDKSMGRSGVGHSSTAHPLDSDNPHHDVRPPRPGEDTSTHPNRLRPLQNTAAMSPDPANASTPASSTNYASPYSHADPRSPPSASAPGPQAKRPRLMNGSEGLSTAEPATTRPPGPGSWPSSTPLLSNLAAPSGQTPPSASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDN0</accession>
    <name>A0A1Q5TDN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrogen assimilation transcription factor nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDN0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="480"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="955" mass="106457" checksum="23EE45CBF3F6F87E" modified="2017-04-12" version="1">MSPEPERPKKAPRKHVTTACVPCRESKIRVCPLPHTTPCEDRRYEYNSNRLPSTSSATAQHPIAKIASGKAKTASINMETINATTELFSARIDQLVQFIQDQGLEPPSMNADDEAGMSRVLDTLQIPRGVARTKISPGNDRKTRTDVNRSVRSDQSPAQSSPSTTPNGQSQHQSQPQSQPLSEIPATTASPSQGNMPSRQLSSVEPWSPVAMVRGAPENQNFVHWGFTLPTAESLDTIYANINGVQGLPVNTGLSRDSFQLGMDMAQQPGVLLSQVPQDRDRDHESDSDEENEAENDVIEQLSHRIGTLKIAGDGHLRFYGATSNLNLVDVSATQQRQRPDARTVRHDGQDILNHLRVGQPVDQALEDHLVELYFTWQNPSIYVVDKEMYMTARLKWRNEFDDTPFYSEVLTNAMCAIGSAFEARYHPTFITFPKSLAEFFADRAKALLEIELDSPCVATVQALVLMSCHEGASNRDARGWVYSGMSMRLAFDLGLHLDMTSYVNQGDMSAHEADVRRAAFWGSYIADHFWGFYLGRPFRMNAGDVTVPKPASTLGAEKEGIWHPYGLQAISKILEDGLQNPTELISRQFVVLWEMVSPVGHILYGCSDISRHDLQRLTFQVTEDLFAWKANLPSTLQIDLDDDATPKLPHLLVLHMQYHQIIIFFHRPWVSKSYIQPRAPRQGPGYLHARRMCVESATAVARLLHIYEKHYTFRRMNNQVVAIIFSAALMLLFVTVSSSPLMPSKPGESSTAHPRNAEMVAYLNLCFRALDELGQSFENAKRTRDYLVALQRRWQAHMRRTGPASKRQNSSANLAAMSGQVPSTQVSHKEHATDSSRKKSRLGDPGAHTRTQDDLMATVHQPYPSSHQYSSHHQPSFQHHPFSAQAAQVSELDWIRNTDLSLLSDGHVNGSSNAMGTISQSQFPDDPGMLPDLGDIEGWWSPPHGTSGMGGTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE94</accession>
    <name>A0A1Q5TE94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase gsk3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE94"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="45183" checksum="4B0E7CADEE3A1F73" modified="2017-04-12" version="1">MSQSRPGLFPSLRMGEVIREKVQDGLTGEHKEISYTQCKIVGNGSFGVVFQTKMAPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGDRKDEVYLNLVLEYVPETVYRASRYFNKLKTTMPMLEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPNTGILKLCDFGSAKILIENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFNKVFRKAPPEAIDLISALLEYTPTQRLSAIEAMCHPFFDELRDPATRFPDSRHHNNPPKDLPALFNFTRHELSIAPELNAQIVPPHARADLEAQGLDINNFKPLSKEEMMAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEH2</accession>
    <name>A0A1Q5TEH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_9057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEH2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="11">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO98617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="450" mass="47703" checksum="04F123AA7BA78C48" modified="2017-04-12" version="1">MRRVVVTGLGAVTPLGVGVRQTWKRLLDGHCGIVNVVDRDERFRDIPSQIAAVVPRGKKEDGAWTASEWLSRGDERVMAKFAQYAMAAAEEALGDAGWKPTSFEHKEATGVCLGSGIGNFEEMYDTVVAYEQGGYKKVNPLFVPKLLINLGAGHISMRYGFMVCIDQPKRHPTPPRKSTLTSAQQGPNHAATTACTTGAHSIGDASRFIACGDADVMVAGGGESCIHPLAIGGFARARSLATDFNDNPEKASRPFDADRKGFVVGEGAAMLVLEELNHARARGAHIYAELKGYGCSADSHHMTAPKENGEGAFMAMKKALKQAQLTPGEIDYVNAHATSTIIGDAAENAAIKTLLLGPEGKQKPADINVSSTKGAVGHLLGGAGAVEAVFSVMAIQDNVMPPTINLDRLADGFDCNYAPNESQARKIDVALTNSFGFGGTNSSLCFARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG29</accession>
    <name>A0A1Q5TG29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG29"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="301" mass="34467" checksum="9549FA7B0E7E911B" modified="2017-04-12" version="1">MDLQSLPTELLEAILTQVDIQTLLLAQRVCRQWANCIQKSAKIQQALFFQPAPKSTPRQPNTLLASKFPYWFPADDHKSCAIAFGAGDMQDFLESSDTYRRSEASWRRMLIQQPPIMALGWVERSIAPSDMVTMHCWEIPLQAFDGLRMNMLYDLIVHKAEVAPEYFYFRVLWSQHETFANELVSLMCNPDPAMLGGQIAGTLRNAMHSADVVLDMWHTIKLPFHMVHQWSEDTWTWELVKGLAAPMGDLEVGLVHDIRELKEANEWSLSNDYPDALHRYMIEANVCGGGMPLPDEDDWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGG5</accession>
    <name>A0A1Q5TGG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGG5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="324"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="573" mass="65867" checksum="B6681FED21676ADC" modified="2017-04-12" version="1">MVSRSKRLQMMFAGDEELLHLDTRLTLQDGPTHDPWNESPSQPVQETPETTVPATVPSTMPPVVPAIEPQPVTQTKPNSSPRMNTKIPEWELRNAFCPARALPKFPFKYVLPKGGALSKQIAREYFDGGAIWNRLWEVYYLPIPWSITEQPLLLISALQVKDFFDKINYELNCDISLKRNQEGLVVFFDANDGTPQPVFHGRIENRGGLDIAEKSIPEPESGDENWTKKCEPAAVRAFAKKVHEAILAYKKKKIKPKSRVPNPLKDELEWRMIQQPPGRGLYHLMSFLGLRPPLYDDNWLNGGEVYDPVNLLEPVRWEPQDSPIFYSVDVEWNERNFTQLTEIGISMLDTLDIRGIPPGVNGENWVKHIKSAHLRTAEYKNFRNSQFVMGYPDMFLFGKSEIVPNEQMGRRTDLFFATPYDGTEDKNRPDLPEHRLVTRNIVLVGHNPDADIKMLAERCTIFNSMDLRPQKLIRSLLDTQELFQRLRTQKNPSKLETILIQLGLEPEFLHNAGNDARYTLEALIRMAMELAAKKMEPKQVSDEEEDPEWKIVEEEKTEQQVVVQEAEVSSSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGH0</accession>
    <name>A0A1Q5TGH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGH0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="3">
        <location>
            <begin position="402"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="64765" checksum="E0E47E0991F8F30C" modified="2017-04-12" version="1">MLWNRLGHPLPSFARRGLTRPLRYNGIVLQATGQRFNSSNPQNTGQYTPDPTDQNESEEGQGKGRKNDSDPNLKSTILKMLETAATTAASIAILGAAGYSYHQYYKYLILDKMDNAFKPGDPALEIAGVVSGKHHYRDEEHWVVRDEQPRIDDIVAGRRGGHYYLIIGEKGTGKTSMLLEAMRKIDGNSCAMFEAHADLEIFRIRLGKALDYEFHEEYSISPVLFIKSYIGSLFSIRGPRDTTPLLDIERAFNKLEKVALKRRQGGSPPLVLIVNSTHLVRDDHDGQDLLEMIQQRAEQWAASGLVTTILNSDDYWVYERLKRYATRMEVIAVSDLPKDKAMTALWKYRKQFCHEDLPGSVLEHVYDKVGGRLSFLNRVAKSQDVLKTCNEICQAEKTWFLNKCWILGMEMDDDVMDEQKYSSAAMVLAKALVDLEKDMEKSYDPHKGHILPEIPLHKAREIMTRADFVQSYDHENIFTIDSRAMVRADSVPMQQAFREICAMEGFDKHLEDTLERIGDIESLGRTRELTIKDLWDNGKYRIVVRDTKGRESGTVEFAVAEREGEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH22</accession>
    <name>A0A1Q5TH22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Laccase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH22"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH22"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012637727" evidence="3">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="69"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="16282" checksum="3BFB24140156038D" modified="2017-04-12" version="1">MKILYIIFFVFALWTAAFTIPGLETRKSKQCTGNAAHTRKKWCDYNINTDYTNVVPNTGATREYWFSIDEVTVAPDGVSRPAMAVNGTIPGPTLYANWGDEVVVHVTNHLFESENGTSIHWHEIRQNYTNSNDGVVSITQCPTAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH51</accession>
    <name>A0A1Q5TH51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH51"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="123" mass="13737" checksum="5B7033123A58F35F" modified="2017-04-12" version="1">MQPAPRSDSIGANRKQRRAAIATWLNAAETHDRYLRDLQKQAYNWQRATGVKRPREDCFRFDDDLDVGHIVNDFGATAELLGSGPGGSPTSPAPDLSCTIWASPFTLPTTVIKDTHQEQRNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH90</accession>
    <name>A0A1Q5TH90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH90"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH90"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="189"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="783" mass="90118" checksum="32D35CC19BCE76AC" modified="2017-04-12" version="1">MSVATMLQPASRISRASSSSSSSFQPVARQNTMSSHDTRSIRQSKRMSVTALYLSMSAKDRDLEISDDLARAQKYLRELKSKISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHLDDTADPQEGFFPNDERTQKYGNLLFLLQSEPRHIAHLCRLVSMAEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLTYQFDNTPEYSSLLRQNTPVSRMMTTYTRRGPGQSYLKQVLADRINSLIELCDVDLEINPLKVYESMVKQIEEETGSLPDYLARSVTAEDAAENKQVQAIIAPRLKMLTDIANGFLATIIESVDEAPYGIRWICKQIRSLSRRKYPDAQDQTICTLIGGFFFLRFINPAIVTPRSYMLIDATPTDKPRRTLTLIAKMLQNLANKPSYAKEPYMASLQPFIEENKERVNKFLLDLCEVQDFYESLEMDNYVALSKRDLELQITLNEMYATHALLEKHSLALTQDHNSHLSLLLNELGAAPPQVPRKENRTITVPLFSRWETALDDLTAALDITQEEVFFMEAKSTFVQILRSLPQNSSVARRPLRLDRIAEAAATLKNDAVMVRKGIRTMELLSQLQDMGVIDRSDEFSLLRDEVEQELVHLGSLKHHVLEETRKLEEVFATIRDHNAYLVGQLETYKSYLHNVRSQSEGKSRKQQKHQELGPYKFTHQQLEKEGVIRRSNVPENRRANIYFMFKSPLPGTFVISLHYKGRARGLLELDLKLDDLLEMQKDNLEDLDLEYVQFNVTKVLTLLNKRFARKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THG7</accession>
    <name>A0A1Q5THG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">30 kDa heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THG7"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="170" mass="19121" checksum="04C62D63A20D62F4" modified="2017-04-12" version="1">MSLFRTSFPSGGDFAPLFRLLDDYDLHRSSRQTTSNRAFHPRFDVRESEDSYHLDGELPGIAQKDISIEFTDPNTLVVKGRTEREYHTTDSNEPAGDDDSTVAETGDQAQTTKPSHRYWASERSVGEFQRTFTFPGRVDQDNVKANLKNGILSVVIPKSPVPTAKKITIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THW9</accession>
    <name>A0A1Q5THW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar amino acid transporter 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THW9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THW9"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="35"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="54156" checksum="5F2243D0B294E879" modified="2017-04-12" version="1">MEEEAAVGVGPAGLPQSGSRWRAARGKRAAGSAGEASWASSVINLVNTIIGAGVLAMPLAISHMGIVLGVLVILWSGVTAGFGLYLQSRCAQYLDRGSASFFALSQLTYPNAAVVFDAAIAIKCFGVGVSYLIIIGDLMPGVVQGFVGGEPVYDFLVDRHFWVTAFMLIVIPLSYLRRLDSLKYTSIAALVSMAYLVVLVVYHFVKGDTTADRGPVRVIHWAGAVPTLSSLPVIVFAFTCHQNMFSILNEIKNNSHFRTTAVVLASTGSAAATYILVAITGYLSFGNKVGGNIVGMYPPGVAATIGRAAIVMLVVFSYPLQCHPCRASVDAVLKWRPMSQPTGTEASPHRHPLLGPRGNRIPEPMSDLRFSVITTTILILSYIVAMTVSSLEAVLAYVGSTGSTSISFILPGLFYYKISSPDSPTHRGLLKEDDEAVDDLSDDDDDTDADGEGSLARSLTESGLLLRNTRHWRKALLRRLSLGLAMYGVLVMVVCLITNTFFIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TID2</accession>
    <name>A0A1Q5TID2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TID2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TID2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="25254" checksum="7F9E9513A31AA281" modified="2017-04-12" version="1">MGLHLSQLCRKPCGEDREVKKTASNPKHTQEKVFAVLNDYLGPESPLPLDLAVESLLKLLPTDAPDSEEICRFGEDCFEIAEMASYKTHLYEHRIFPTDPTYALWAMRAAFEDERSHEAKEVRSSWILGAAQWILWNGQSIFNLVLEPALYDVTYETWPDRGAWDAGSLYNGAPGLSLERWQFWKRQFGEVSQGCDVTDECKMVSARAMAMMDLFEKSMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TID4</accession>
    <name>A0A1Q5TID4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TID4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TID4"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9272" checksum="DCEAB039A23011F5" modified="2017-04-12" version="1">MKPVVSALNAWSCVVISIFAIVILSVLGSLYGSNNHSFTGSEGDPEDGPAVAASIYVAVIVYAGFFVFCGFQAYLHLRDSRGGAISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIE0</accession>
    <name>A0A1Q5TIE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIE0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="17093" checksum="7971A323CFCC0712" modified="2017-04-12" version="1">MSSKFPTNKKLENPGHVFSAVAHRGYRYCIQYGPDLICRRDVFVKLICIEHSLRATVQRVDMVKNKVKALEKAASIENNNTQLNDWKVELEQLQRECWKQDLKLYEHEKLIPEWPLKQNYDLLRENGAWYMIKELIKDSGSNSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJW7</accession>
    <name>A0A1Q5TJW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="10015" checksum="A7F5123B4AD5B41A" modified="2017-04-12" version="1">MTDADLVCDLKPIESQIGQWSQEQDEPQISSAISSMMDTLLEVLRRLEAEGACVCTHQSQQASGPQEEASFGGLSAMSVTEIPGMWNPSSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL19</accession>
    <name>A0A1Q5TL19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Meiosis-specific serine/threonine-protein kinase mek1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_7491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL19"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL19"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="135"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP00910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="639" mass="71886" checksum="CE26AFB5666AC719" modified="2017-04-12" version="1">MTKFSSEEMQKDGTTSPAYASNFQIDLSYSRGSQFHITNLFVSNKHVRVYTILFDQDNLGGIPPLVYAQDLSMNGTFWNDYRMGKDKGSFLLTDGDLLRVAVGIHVQFKSAGPDNENKFTQLQQLEMKKFQKSYVITQSMLGSGAYGRVHMAFNQNTGRQFACKIVDLQAVRADLQAQAREAQAGLGEQHHCKFFAKQPEPRNYMFTELVTCGDLFSFVRNRGTNLEDTTVALIMRQILLALEYLHDRNIVHRDVKPDNILMTSLEPGGRVVLADFGCARLVNQPVQRMSSIVGTPEYCAPELLQTDLKGYTKAVDMWSLGCVAAVLLVGDTPFDNTYRSTSSDLINLDHDMRALEIDPRARDFVFRSLVLDETKRMDVKQALRHDWFTNPAQAGWFKEMYSRSIQNWKPRNASEAVTVELTSFKSVQTKWPRSESVSSWSPKEGARFADVDHISESSWENVAPASMKPLISPAISIPAPAKRTSCRPPLVPLGPNPNKPKHPQEIISPDADVKFVSQVKCEQLDRSKLERHVLYVSPCEGPNVQRAESKKAPASKGGKQTTKAKFTINKDTGLKNFFLSSHSAAFPPIPSMRTNFPKMSPKDEGDESDQVYEEVRNPVTGKRKRLIYGRDMESLSQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL74</accession>
    <name>A0A1Q5TL74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL74"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="360" mass="39185" checksum="C56FDDC430A8F81A" modified="2017-04-12" version="1">MTTEFRMPIHQGPPARKPMPSQQAGYPYQAYDAPRNLAPHSAYPQTTHSRTRTTSSHVLPAYASNSQQQYQGIPGPAVSPHTMAPPIGYPSSRRMSSTTTSTNSTGNMPQGGPDIRRSASNRSASSQLGYVALMRRQKATVWCDRAQPEDARMREQALRDKKRAYLEVHGAGRSSTIASGKIRHGTKAGMDFSPSNLVGAKVPVRLSANEIGEEDDDARSNEERGMHRRTGSGRSSLGSNRGSNRYPSGYQRQQTMGSNSTPPNEKSDLPGVSENTPAEKHAEEKSRLSSLVKDDAATTHTTNSSEQEDFVPDMEAPSAVVTAAQKAKKADDLRRRGSVDDRTTSMTNVRLFVANPDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLA9</accession>
    <name>A0A1Q5TLA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLA9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="156" mass="17496" checksum="B1DF4E84765DAA3E" modified="2017-04-12" version="1">MTSTTRRIPIRRPNPVVAGLTATTGSARALRVNDYDSDDDFNHEDGNDDSNGNDNNGNDGNDNDGNDDDFQVCIQALNNRLSAIQPSIQRRIQVDRYQSLIDQCIRDLCRDVGGLAHAVNAMQRAQDQEMIRVNAELAELRAQLERELRNLSRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMC1</accession>
    <name>A0A1Q5TMC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMC1"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP01370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="15784" checksum="D1765362D0A262FB" modified="2017-04-12" version="1">MGKGKPRGLNAARKLEAHRKEQRWADLHFKKRLLGTAFKSSPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVKVQLIKNGKKVAAFVPNDGCLNFIDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLAALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUA9</accession>
    <name>A0A1Q5TUA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUA9"/>
    <dbReference type="OrthoDB" id="1858978at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF110">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="2">
        <location>
            <begin position="83"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="40956" checksum="999486FB78032548" modified="2017-04-12" version="1">MSATNSQSGINTDPEAGSQSRNRIETAQYFVGKTASLNILKTSVQPDGQIIDWIPIESQGEIASPPPLPAFPFHPSPNTKVTSEPDCQQATGPLFSLEMEGAEKGPGGTVPILRQDLKLLSNKPTLTQRLSETAPSTKGKRKLQSMATLTIEVGWIIYPAQVAHPHSFTFFNTNGYTQISDNKGGWNTEVKCWVQYDNTISPGATIGPLCADGGLQTIIPIKVPLHEGNWRVYVIDRWIRYYPASLFRTDVADPAQTLAQGSDQVSWYGAVYQTDETLTSTNMGSGEWPWTRFTHSAFIKNITWIDADSILHDYDGTQHSIVSDEEGYTMETHYKSGFDWWQSYMWIGGPGAGGKIGAESERTKDTEVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B2</accession>
    <name>A0A1Q5U0B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0B2"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="168"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP05920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="738" mass="84518" checksum="595EC7C34C7429ED" modified="2017-04-12" version="1">MATATEANALGYNLKVDYVINYNFGDLDQAQAIAQLEKLLRALANAGLECEVRQGDETSLLVFVRASKKRLNRAVYRSRVRDWLYGIRNAEPEPASSIEPQNEGERLRAINHMITLPTEEGGAGITPNHGEWKNVTGLLPLHDEETNKKWLHEWSQKTFLSEDDLDQIRDKFGESVGFYFAFLQSYFRFLIFPAVFGFSCWFLLGGYSIVYTLVNSLWGIVFVEYWKRKEVDLSCRWQTKGVSAVETKRREFKPEKEIRDEGTGEMRGVFPATKRMQRQLLQIPFALLSAIGLGVIIATCFAIEIFIAELYSGPLKSYLVFIPTILLSALVPTMSAVLVSVATKLNDYENHETDETYDTALTQKVFVINFITSYLPILLTAFVYVPFASHIVPHLDIFRLTIRPFVSDEHATTADCSHFKIDPHRLRNQVIYFTVTAQIVGFAMETIVPYIKQHALREYKAYNKKKNGKSENNGDKDSPERSPIMTYDDPLEEKEFLKRVRNEVELPDYKVTDDLREMCIQFGYLALFSPTWPLVPLSFFINNWIELRSDFFKICMEFRRPTPLRCDTIGPWLDTLGFLSWVGSITSAALLYMFCGDNQLGPNGEPTDIKGWALLLVIFFSEHLYLIVRYAVQTAMNRLEPPNARKERGERYLMRKRYLESTLKAEANEETEKEDLVSEVPPEITRSALEADARRNSGHSADPAERFWMRQRGWTESAKVGAGIIQAQPSKGNAKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1A7</accession>
    <name>A0A1Q5U1A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIA large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1A7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1A7"/>
    <dbReference type="OrthoDB" id="6275927at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000006">
        <property type="entry name" value="Transcription factor TFIIA complex subunit Toa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="379" mass="41320" checksum="9B0C8FC91E2038A7" modified="2017-04-12" version="1">MSNQQVGAVFEKVIKDVCENSQVDFEESGVDQKTLLDLRETWQKKLSSVNVAQFPWDPPVQPIPQAPLPPQATVPSNAPRPPPQPQHVPPPVSMPQQVPVQAPVPVAPVAPPPMNAPRIKTEPGTNGPPQMPPMHHNMPANTPNPQMARDRAAAQLTQRFGASAATSVSQLQSQPAGQQPYPQMHHPSNGQMPQIKQEHGHSSIGPSQTDGADDALADWKAEVARRREAAQNGQGDHLLREYLKHQMSGLQGGGLLRPLSEQESSITTARRAALVAPLVRANASQSNSEFPKVPGQFDGVDDDVKEEADEDAINSDLDDPDDLIDHEAEADEADGQVMLCTYDKVQRVKNKWKCTLKDGILTTGGKEYVFHKGQGEFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1E4</accession>
    <name>A0A1Q5U1E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1E4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1E4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="47229" checksum="DFD64F1B4EDACEC2" modified="2017-04-12" version="1">MSGNSWLATEQWATAIAKPPSLKCIAPWEGFTDKYRDLICRGGVPKNNFASFIFNKTIRGRNDREDIGEALNKWPLFNGYWEDKVYDTSNLTLPIYALVSYSSGNHGSGTVRGWNQAASKDKWIRFHPTQEWFDLYTPRYIDDLQRFFDRYLKGIENGWEETPKARVSILTYGNRFEPGPMWDVPFANYPIPSTEYRKLYLQDSGNLATSLQAHESFVAHHADSYQAKPSEFVLTFDKATSLVGHSKAELWMSCKDKDDMDVYVSIRKLSKSGEVLEHVNVPWESLPEGVNTQHDVPMAQTVKYTGPTGILRASHRAQVPERSTAMIPYHPHDKEEKVPPGEIVKLEISLWPMGIHFEAGESLLFRVQGFIDTSSDFPSHIDKKLDNLNEGRHTIHFGGKYDSKVIVPIIALPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1R7</accession>
    <name>A0A1Q5U1R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1R7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1R7"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP06433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="45174" checksum="EDDA5ADAE2869C5D" modified="2017-04-12" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDASSKVGNFPFTTIDPQRAIGYLQIDCPCQRHNVSDRCQPNYGGCVEGRRSVPIELLDVAGLVPGAHQGRGLGNKFLDDLRHADALIHVVDVSGTTDAEGKATRGYDPSVDIEWLHSEIVRWVLGNLMEKWGSIKRRHVATKANPVDTLQGQFSGYGSTSTIVARCLDRLGLKEPLEAWSDETVEIVVKAFIDEKFPTVYALNKIDHPDADKNISKIAKMQDPQSIVLCSAISEVFLRRLAKQGYIKYVEGSEFVDAREDLIEMGDPEGGGLKEMDEKLKSRVENLKDMVLYRFGSTGVVQCLSRAAELLGLVPVFPVRNVQTFNSGSGSAVFRDCVLVKKNSTVGDVARKVMGDVPISYIEGVGGTRVSEDDIVAVGKHDILSFKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4S5</accession>
    <name>A0A1Q5U4S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4S5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4S5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41253" checksum="D0C4DA9BDF766A11" modified="2017-04-12" version="1">MSSMGRAIRRLGSSRKLNTAEGISTDSLISIPEEAPQVNLAPVDTQLNMHRFNTLFEEEMAVEGPKDSHTLPAQAPTSASPRLGNEAPAEWSAVGHAAATGKSGRVIHNLQEEVARLKRDSALWQSRAEESQRTSEALKIQMEEMADWLRHKEQVNETSLKSIDRKNRKIEELRAELHAERTKRHDAQIVANETNEAMRVERQNHNRETARLQEEAKYFKNQYEVLSSATKREKADLERRVDKAWEKVNSIAETSSTQGECAKRLMVIGDQKNREIDGLYEVYNKAKALHADYKETKDKEFRGTIDRAHANNALIDATLKELKETQDKMRWVIRMSELNESKKANGQQTKEAEEQPTSEPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U800</accession>
    <name>A0A1Q5U800_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_5582</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U800"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U800"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="49"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP08595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="41955" checksum="7F98F1D2585DCBC6" modified="2017-04-12" version="1">MFSRTAQPARTLLRSASVAPSFGRSIPARTFATVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPIEWEQVDVSGVDTGNKHSEELFRESLASLKRNKLGLKGILHTPVERSGHQSFNVALRQELDIYASISLIKNIPGYETRHKNVDLCIIRENTEGEYSGLEHQSVQGVVESLKIITRAKSERIAKFAFSFALANNRKKITCIHKANIMKLADGLFRSTFHKVAEDYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNIAAALVGGPGVVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPSALILSGSMLLRHLGLDDHANRISKAVYDVIGEGKTRTRDMGGQATTHEFTRAVLDKMESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U870</accession>
    <name>A0A1Q5U870_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U870"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U870"/>
    <dbReference type="OrthoDB" id="2663223at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="162" mass="19005" checksum="5BD7CB1C74479668" modified="2017-04-12" version="1">MSLVQDTPSQNATEILWDKRLHSDAQWRSWIGHIKAIATKAGIWNYINPSLAEDKLKKEPVDSRDTFPQVSEVHRDATDISDLDEDQYGLYIRIVNLFDKERSFNEQLRNKINRINSLIYQNVAPEHRHILKGKNTPYKKLVRLTQQFAPQGNNRRQRVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA08</accession>
    <name>A0A1Q5UA08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA08"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="25443" checksum="81055AF79AD361BC" modified="2017-04-12" version="1">MGDPFSVAGSAVGVVSLGLQVCQGLVSYINKYKSADKEVKNIKCKVEGLNLILQELDDLLKGVDGTDPSLSGKFKVALRMITDCESGIEDVKITLSKIQSYSSEPSQAVFPNIKTASKRALYPFRRDALVDLLTVLEGLQENLDTALALSHVITTGAGGFAISPNLAFRAIVRDSPAFELMTDAIESFRYSGGGLELLKDLRVKLFRLFQEGKASPTDTDQYGDTIFHTLSSNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA58</accession>
    <name>A0A1Q5UA58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial chaperone BCS1-B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_5293</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000532">
        <property type="protein sequence ID" value="OKP09362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA58"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA58"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="15"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="205"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP09362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49371" checksum="7E9536E664A965FF" modified="2017-04-12" version="1" fragment="single">RRQVLLRPTIEEDKVDCLRWCIAFPYARLSTSTVHIQSSNEMHDMLTSWISSRGLESTARSFLAKVDTAPGATMNDTDKKLLKLLPHQGSFYFWYKGQLLFYEARQEDYRYFDQEKITLTSLGRSSYILKDFLQECRSEYLNKIRDKITIFGHRGVQWKRDRVKEARPLSTVILRESEKAPLVADMKDFLNARTRRWYAQRSIPYRRGYLLHGPPGTGKSSFSLSVAGELGLDIYTVSIPAVDDQSLKSLFQELPANCVVLLEDIDAVDSAHSRDSMAATPASGQELSTVTKGVSLSGLLNVLDGVASQEDRILIMTTNHVNALDAALIRPGRVDRTVRFQLVDQDVAMQIFHYMFAQQGDASNQDPHSQPRLGVESQAREFARKIPEGRYSPAQVMSYLLQHRNEPDVALSNLERWVESTNGPIAPVQRRSVSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA77</accession>
    <name>A0A1Q5UA77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000525">
        <property type="protein sequence ID" value="OKP09378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA77"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056634">
        <property type="entry name" value="DUF7732"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42091:SF1">
        <property type="entry name" value="CONSERVED GLYCINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_7G02440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24866">
        <property type="entry name" value="DUF7732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010159587" description="DUF7732 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7732" evidence="4">
        <location>
            <begin position="189"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="359" mass="36377" checksum="81EEA1006C9A3C17" modified="2017-04-12" version="1">MKLAWATTVLLLGSQGVTSLSIPFAPQSDLIERDPNSAPVDSDFVDLEKRRGGGGGGGGRSGGGSSGSSGSSSSSSGSSSSSSGGSSGGRSGSSSSSSGSSSSSSNRGGSSSGGSGVSPSYGGGRYDYNNPSHGTTYGSSGSGSSGGSSWPWMWNSRSSSTTGAKTPKQKPPKTPNKIPKAKTFGNNRYYAGGARSPYTAGARTSSGISPYFLPVAALAFFPGIWLAGAYAYSYPHGYYYHNADDNKNETLPVQCLCEQNQECGCDDNNNSTYYESLFNGTQPRNTSIARVVNVNGTKTIVINGTLANGTTADDGTSSSDSTTTSSSTSGAAQGPLVTLINASGYWVMVAVVVATVWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAC0</accession>
    <name>A0A1Q5UAC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAC0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="512" mass="55574" checksum="A3D41116DD38441F" modified="2017-04-12" version="1">MGEIISESSVVESKREGSTMNADELRLAQMGHTQELKRHFSILSLIGLASTTTISWTGLGLGIVTEINAGGPGAIIYGFILVTIMQSFLGASLAEFVSSYPTEGGMYHWIAAVAPKKYSAFLSFMTGWLTVCGWIFTTASTNLIFAQVVQALYALYHPDMAFKTWQTFVIYQILNALTAAVVLFGNKIIPTLNKFSLFYLQIGWLVVLVTVVACAPTHQDTTFVFKTWINNTGWSNNGICFITGLVNPLYSLGGLDGVTHITEEMPNKQPSRNAPLAIAITLSIAFITGLTYLIGLMFSVQDYAALSTTNTGLPLAELFHQATQSAGGAFGLTFILFIALGPCVVSSQLSTSRVLWAFARDGAMPFSNVWGRVSQRFGIPFNAQLLVGAANAVLGCLYLGSSTAFNSMLGAAVTINNVAYLIPIATNMLTGRLNMHKGTFHMGKWGWLVNGVTVGWLVFAITFFSFPYTMPLTAQNMNYTCVVVGGLPILILGWWFVGSKQYKEKIANAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAI7</accession>
    <name>A0A1Q5UAI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000515">
        <property type="protein sequence ID" value="OKP09477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAI7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30338" checksum="0176243905D7E648" modified="2017-04-12" version="1">MKQVDGPMIVAGIRTCCTKSVYHHTDMRDWRGVRLNDVRKQWDRRHSEKPDNIISQYGNRIIKISDDQVVKWGPDVTKEEAENQRIAYELVDNRIVHIPRVYAFFSDEQGWGYIVMEYIEGKVIDPLEDINAIEKVAGVLDYFATLRHDIPGPLSGGICRGLLFPETEDLVFDTEPKIQILPKHYQEIQSIVFLHQPIQCQIIRQAGMSKLSGKALPRQDPLLALLYAPLEEPENKIEFTIASLVICAQFGLRTLNHLMLRKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAN5</accession>
    <name>A0A1Q5UAN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000504">
        <property type="protein sequence ID" value="OKP09533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAN5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="55433" checksum="75EA8613DF364A3F" modified="2017-04-12" version="1">MRQIYQACVTPVVDYASTVWHGPLRDKTHLRHLNTVQRAPLIRILSAFRTVATATLEVEAHVLPTHPRLRRRAQHTIAKLHTLPRNHPIWNTLLRAQRRRNNIGNYARFPLAEALKTMELQKLDELETIDPRPPPPWRSDPFTEIELDSNRETAVERAENVRHTSDIVVYSDASGREGYLGAAAVALDDDSEIVKSQQIQVRPMDRWSVHVAEFIGIFYAISMVFKVTHRLLGSLERRRKTGTILCDSRSALQATQTPRNRSGQQIVHAILQAATEVQTEGIALRLQWVPGRCDNPGNDAADRLAKDAACPGKTHPFRPLLSRESARLRSNILNQWEQEWRSSNKGSHLRKLDRTLPATYTRRLYGSLPRNRAYLLTQLRTGHNWLSTYAKAFRFRDDDRCVCGAQETVTHVLVDCPDLRDIRRELRREVGDAFSSVSSLLGGSTEGKKGKPDTVSRAKTVKAVLDFAEASQRFWSRAPRGQPNSGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAP3</accession>
    <name>A0A1Q5UAP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Norsolorinic acid ketoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000503">
        <property type="protein sequence ID" value="OKP09542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAP3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="196" mass="21025" checksum="96727B5B0C4C86BC" modified="2017-04-12" version="1">MGLVILVTGANRGIGRGLVAHYLAQPDTTVLGAVRDASSLNATELDELPKGEGSRLIVVSLSANNPMDATEAILEIQMQHLIGHIDIAVANAGICDHYGPVEEMTDSDVLSHFEVNTLGPLRLFRAISPLLRKASVPKFAYISTALASIHMIEQIPSLTAAYGMSKVAGNYLVKKIDAENKEFIALLIDPGHEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAW7</accession>
    <name>A0A1Q5UAW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000475">
        <property type="protein sequence ID" value="OKP09612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10033" checksum="393C11630865E9D5" modified="2017-04-12" version="1" fragment="single">PREELNLLRAAQLKAMSRESLRQFLSLPNNFPGKCPFTGIVKVNALPCGSGSYVGGVYPTVSRINHSCILNAHNSWNSSKEQETIHAIRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB21</accession>
    <name>A0A1Q5UB21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB21"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="165" mass="18306" checksum="836DDEF52D07798B" modified="2017-04-12" version="1">MPVVSRLVSIPLRIAEIAFAAVVAGIVGHILASFDKIDGWSDGRWIYTEVIAGLSILLGLIWLIPFSSGFFNWPLDILISFAWFAAFGILVDYLHDLPCGSIWSWRFGGDGFCGRWKAAEAFSFLSAIVWLASAIVGLWFTYRVRDHGVGTTRRSRWGRRGAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBY7</accession>
    <name>A0A1Q5UBY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000417">
        <property type="protein sequence ID" value="OKP09995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBY7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBY7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="161" mass="15989" checksum="F03A9489CEF9B5BA" modified="2017-04-12" version="1" fragment="single">MAKQSAVTSASPNPLATLTPSAAALHLVSSVDSSPLPPSTANPYTGVAAGAGAMVNPFATLGAVGENLAIPQPRGHSQTLSPLVAMLPQWPAAAPAMDGKAMSRQIPPLQLLSQQGISQDQWVAALQLVTIADTMGAANPAQLPGFGAIPCQGSGGGGHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCM6</accession>
    <name>A0A1Q5UCM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UCM6"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF13">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012457152" evidence="1">
        <location>
            <begin position="19"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="854"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1335" mass="139322" checksum="53082086D6B23E70" modified="2017-04-12" version="1">MKFAAAALVSLGLSGAHALVDIPAVSSVVSSALSEYSIYVTHALNPTATATKTPAKATNNVDILARGAVSDPAYWLAGISHRGVAAFNSNPSTYTVFRNVKDYGAKGDGVTDDTAAINAAISAGGRIGPSNGQTSTTTPAIVYFPAGTYIISSSIIDYYFTQLIGNPNDLPVLKASANFPSTWIIDGDQYQSTGNQGWGSTNVFYRQIRNFVLDLTAVPPTVGATGIHWPTAQATTIQNVKILMSSASGTQHQGIFIENGSGGFMSDVTTVGGAYGLNIGSQQFTMRGLTISNAVVGINQIWNWGWTYQGLNINNCGTAISISNGGIDNQAVGSVVILDSTIQNTSKFVDTAYTSTSYSNGSLWLENIQLSNVATAVQDNGNAILAGSSGSMTISGWGQGHSYSPSGPHKFQGPMEPASRPSALLASGTSNYLTQSKPQYEASPVASFLSVRAAGAKGDGQTDDTAALNAALQSAAASNQLLYIDQGTYVVSDTLMVPAGSRIVGEAYPVLLATGSNFANINQPKAVVQIGNAGDSGLFQWSDTIVGTRGSTPGAILVEWNLAATAGSGMWDVHSRIGGFAGSNLQVQQCPTTTAVSSACEAAYMSLWVRSSAKNVYLENVWLWTADHDMDSPANTQISVYTGRGLLVEGSNIWLYGTAVEHHSLYQYQFSGASNIVAGFIQTETPYWQPNPDAAHGPYSVSSSLRDPVYTGGDAFGLRILDTQQISIYGAGLYSFFNNYIGTCSAYPTPENCQAAIFSIEGSTSGLKVFALSTVGTINQVIQDGTVLALASDNLAAYAETIAYLAPAAGTGSNSTTTSLTTSISSTMTMSGSTTLATSVSSKSATSTAPVTTGWALVGCYTDNVSERALPSGIPVPGGASKMTVEACQAGCQALGFTLAGLEYAGECYCGNQVQGGNGPAPDGNAQCNMACNGDSTETCGGPNRLDLYTYGRQTATTAFTTTATASSTVSTVSATSGTASATSTSGATGWVSLGCYTDNISERALPSGIPVPGGASKMTVEACQAGCQALGFTFAGVEYADECYCGNQVQGGNGPAPDGNAQCNMACTGASSETCGGPNRLNLYQYTSSTTPVAKRGLAYNNNNPQDNAMYTTFFAGNSKISWGYDWGFPSNGLPSAWEFVPMLWGLPSGADPDWTAAVKTADTKHILGFNEPDLIYSASSNILPAAAAQGYMTYMQPFAGSVKIGMPSVLWNNVGSSSGGNYNTKQWTNYFLGNCTSCTLDFGAIHWYQDCNAAWFKGNVTDAHATLNLPIWVTEFQCYGTDAQQIAFLQDVLPWMDSQPYVERYAYFGVFPGYLLNSDGTALSDIGKAYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDL7</accession>
    <name>A0A1Q5UDL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDL7"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="31"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="39209" checksum="619ACD571F3D3A2C" modified="2017-04-12" version="1">MKPELRETWTPAINVLTWFMLVTSILSVFTRLGTKYWIFRKLTVDDFLSIAALLACVGQSIAVSVATEGGLGQHFLPLAASDVEKMMKSQYAANILFVIGMCCSKLALMMFIRNLSPASLDRQFALSLGMFIILWAITGVFTAAFQCHVPATWDYINGECFDLVAWWNYLGVTNIISEAGIIAQALLVIIRVQADMHKKIVLSSVFLFRVVVVIAIICQLAYAKDTKGSGDPSWDTWTVVVSTQMTQALSIVTACSPQFKPFLDSLRSSGMSLGGTSYGSRQRTYAGTTYKVSRGHRTGETPSETHELVTMPGDTVNQTIVTSSPDCDAESQTSQSQIIREVRTWTVTETRREYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEU0</accession>
    <name>A0A1Q5UEU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEU0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEU0"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00445">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="301" mass="33821" checksum="44AFD467D5B0C5FF" modified="2017-04-12" version="1">MSNLAAARYGKDNVRVYKVHRDEKTGVQTVVEMTVCVLLEGDIETSYTKADNSVVVATDSIKNTIYITAKQQPVTPPELFGSILGTHFIEKYAHIHAAHVNIITHRWVRMNIDGKAHPHSFIKDSPETRNVQVDVIEGKGIEINSSIDGLTVLKSTGSQFWGFVRDEFTTLKETWDRILSTKVNANWQWRRFASLHDVKANVHNFDFAWETARNTTCKTFAEDNSASVQATMYKMGEQILAAVPLLDTVEYALPNIHYFEIDLSWHKGIKNTGKDAEVYAPQSGPNGLIKCTVARGQKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEY4</accession>
    <name>A0A1Q5UEY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEY4"/>
    <dbReference type="OrthoDB" id="5431381at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="671" mass="75731" checksum="01AD644F4E095EE3" modified="2017-04-12" version="1">MSDFSSLTGKFRINKEAGQDPAAKVTKRPRESLACNQCKRAKTRCDRRHPCSSCTRKDEAAICSYQRASPGSNRSATAEDRLAHLESLVKDLMQNQNLRQPEHNSAPVEDQSTEDPRVTDQSLEEGRYVGSTHWSAVLDDIQELKIAVTRREDSPEPSPNLSSSPDSNKASIIFGSPSDYPLEQVMDQHLPSRVEVDRLVSIYFQGESFIIPFIHTFQFQRQYRAFWAEPTQVNPLWLSMLFSICAVSTLIRGTIGIYPTAREEVITEACQLLAASEKCLVRGEYHRPQPLVLEALIMYAQCKNMQSLDPSREAGAIFGMVVRMAYEMGYHRDPDSLGSFTPFEGEMRRRFWSLCKQVDLMVSFQLGLPSNICLENCDTKSPRNLTDSDFDVDTEVLPPSRTEDEPIGLLWFIVKDRQMVSFYKVCRDALSFHEKSHAEILQLDSEIRQIFTTIPNILRTKPLADSIADPPFLIMTRIYLEFIYLKSLCVFHRKYMTRGNQFSTDSCMEAGQRLVRLFIETHAEFLPGGRLDGHRWMLTNFTMNDFLLGVMVLCLVIHVHRRDPQSSVISSKAEEGILPLLKQAHAICVEKSSVSRDARYVSRAIAALLNGPVTKVVAPALPVDGSNINAVDNISLGWWDPFYIEDSNEGLDWGLLESLLLNQPGEGAGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF03</accession>
    <name>A0A1Q5UF03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF03"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF03"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="34022" checksum="94519003F43D8AB6" modified="2017-04-12" version="1">MKALHAIGHLNFMLPVRSCPLLRILNKPTCIQSRHPGRRTHFSDGRIPFSPTGKVPWEGIHMSRCNTHLKKPDLPWGFSIYRCTYKDDKAWERILQLLQDSVEEFLEEGAPDLIPYHQLVINDDVTNFDGATSHEIRDHFNAWVKEQLSLVANYPERLHMFGGSCPEYSFGARFNYALFVDDICLESLDHMTSPVVKILYKQWGNLTPEERNYKIHPDWHDGTTEMDEEDVGWMYMCADEYVELYDKFEWSYFDMWYAFYMRPPLMDGQVPERRGDRSELPGFWRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFN1</accession>
    <name>A0A1Q5UFN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFN1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="169" mass="19635" checksum="D37666197516460B" modified="2017-04-12" version="1">MSETYARQIGVKIETGHRHRRRVIFADNSVAETVGMAYNVEWRFGYLGYPDPVHQLDFRILRDSPADVILSDAFLFDNEVFSKYQHLLIDDDEEFEDEDTETYFFAIDIDKRQDQLQGISPKFRKYADSNLLANQHSYALADLQHLELVRRGEEADRISTLSGNERIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFX9</accession>
    <name>A0A1Q5UFX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000282">
        <property type="protein sequence ID" value="OKP11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFX9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="276"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="579" mass="63824" checksum="48CE8A9225FE4514" modified="2017-04-12" version="1" fragment="single">IFALLKAFLAQLRSYYLRTMPRDNVSRVKKTNTIGILTFIGLRAADSVFQYALLQRGWASSLIQRLGAAAVSRDMIAHTSTGQLRPQYAMIAFMALGSSVKQILNILLVLEQEMSPLSAVAIALFNTICNSLNALLSVWAVTSQAPGPDSFLEILQNPLLLAGVGFYVVGIVVEAASELQRTAFKKDSNNKGKPYAGGLFSTATHINYGGYTIWRAAYAYTSAGWPWALGIFSWFFYDFAARGVPVLDQYLLDRAPSGRSKEQAAADFQVFYSSLPSTDMKVFTDGSKLPDGMAGAGFALYQTGRLCLQSSFSLGPNKEVFDAEAEAALAGIKAATQSYNARFATDLWVCLDNLEVATRLLSPFSGSSQEVFETFRTLALAWPERERFSYTNGGTVRICWVPGHAKVPGNEAADQAAKRGAALEPPVPPIYSFASLKRHTKAAMISSLQRHWQAVAPQSYQDLWITSFTSCPDELRLPRYLLGRILAARTGHGDFADYHERFNHEDAHLHCRCGARKTPVHFFFCRVAKRRLPRPSGPPSETIPFLLGTPKGAAQLAAWLSETRFFDDICPRRPLLEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGB3</accession>
    <name>A0A1Q5UGB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_3011</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGB3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGB3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="317"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="359" mass="40670" checksum="851A4C4B5D45ED55" modified="2017-04-12" version="1">MSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRGARKAEATEAHEEAKETGTAEEVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFETPILLRHLTFSEQRKEPIQEIHLDKAMEGLNMDRKQFIDLCILLGCDYLEPIPKVGPSTALALIREHGSLEKVTEFMNNDPKKKYVIPEEWPYEDARELFANPDVRDANDPECDFKWDAPDVEGLVQYLVGDKGFNEDRVRNGAARLTKNLKSAQQSRLEGFFKPVARTDEQKASLKRKQDEKLQEQKKRKKEESKAKKDAKAKPRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGE3</accession>
    <name>A0A1Q5UGE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein C21C3.12c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGE3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGE3"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="127" mass="14043" checksum="58C2BE1F2E25CA16" modified="2017-04-12" version="1">MPIIKNFTLPASAKLLEVPEGPKAKLFLAFISGDDAITKQPWCPDVRAALPHIDAAFTAPDAPTVAYVSVGEKLQWKDLKNIYRTQWKVNNVPALVRYQLVKGEVSETGRLIEAEILDKAKLQAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGH9</accession>
    <name>A0A1Q5UGH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2892</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGH9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293418" evidence="12">
        <location>
            <begin position="17"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="24612" checksum="FDE9C5D95F1AE9F7" modified="2017-04-12" version="1">MLHPVAFLALIAVAQGHTVAWVKGMYCLGGPDLSTDNANTNTAVGPLYNLTHEKWWFQHDRGCDAAPPAHGDILQLPAGGTFTVELAHNRAQTTLSYDGKYTSEWPDGKEHPEDWAGPGSPADCIQDDGAMHTNNQSMAAGTAFAISYQSDLAAVTMENLAVFTVLEQYMAGYKCNVTGSTSSKHVAAAQVAAYCADDTSKCVKGAKQMIAFNRESVILPDSMPRSNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHM2</accession>
    <name>A0A1Q5UHM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Respiration factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHM2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHM2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1180" mass="128308" checksum="42BB4BE2597475A9" modified="2017-04-12" version="1">MLLDAMVGHERDQSPQLVDLASINEIPGNMPAPSKETKKQAEANGQTGTNGNIPPPKTDKPRPHVCTTCGRSFARLEHLKRHERSHTKEKPFECPDCARCFARRDLLLRHQQKLHMTTTPSSRPRNGRRESTGAAGAGAGANRVRKNSIANSSASMRPRANTISHIGTSALGIPDGSNPSAPGQSGHAYHPSLGTSLGSSVDYRGFSSGHPPINGLPKLETSGLPMDMAGGLRTAPVHGSFDLGIDGMLMGHGSTINPAQLHFAGSPQGFGDSPSSPFGHQQYHGMPHPDSMMDEEMNFDWMNGFDAAVALGNGNDSVIDESSPSAMSTGSQSGISEAMLDGPNRIPISNGWHNPFPGQTAMSANQFAIDFSPTTLNELGIPPETVSPKSLMAQNPFAETYATPPSMTSVGQPIVGGHSQSMFSSSMATNGESPNPLNVPFPNSALRNQHSPVSTDTFTDSTRQALLASMSQPTGFNHRKYSQPASSLMNSRELFSRSAGFNTSGQLPSTSDMQRYISAYITYFHPHSPFLHIPTLNFQAPEYTSNLRTPSGHLNLSSTGVAGGGGCLILSMAAIGALYEYDTAASKDLFEAAKKMIQLYLEERRKADMSAALSRSNSVRDNSVHNTPLWLVQAMLLNVIYGHTCGDKTSADIASTHCAALVSLARAAELTHHLDPKNLPQDHLNSGFNASDPSDTENWMSSSFGQPKERRDWLNWKVVEERKRTLYAIFVLSSFLVSAYNHAPALTNSEIRLDLPCEEDLWAAESPQAWKKMGGQTAKKSASFSAALTSLLTASQREQQNKSSNLFFNGGSTDDPTSAENRPSTFGCLVLIYSLHNYIWETRQRHMGRQWTAQETEAMQSHIEPALRAWQAAWASNPVHSLERPNPFGAGPLSADSIPLLDLAYVRLFVNLGRCKEAFWQRDWNGMADELARGTEVFHQADGPINDVLDPSLIGSLDARRESVNDLGVGELAISQTPTQDQPMQSLSSVYKTGQSKREKHLRKAAFYAADSISMSDRLGNTFAEFSSRELPIQCAMCAFDCAQVLAEWITTVQERVGPYLGILGRDDIDLTQVPGVMLLEDEDCKLIDKIKEILSSIETKMQRTVQNSNSMSALSVMQRLPSVVEGGYGCKILIATASLLDRAAVWPVTKLMARSLEAQAMRMKERAEHSCSHAVMMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIG4</accession>
    <name>A0A1Q5UIG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_2003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIG4"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="39953" checksum="DD1650E007A83DE6" modified="2017-04-12" version="1">MVPKVCASGRTMPPRSHTHTRSSRSVSTVSVVLAAFVHGFRGTRIGQNEKHPNIPPSIADGGVDVVAVNDPFIEVHYAAYMLKYDSTHGQFKGTIEIDGTTGLIVNGKKIRFYSERDPATIPWAETGATYVVESTGVFTTTEKASAHLKGGAKKVIISAPSADAPMFVMGVNNNEYKSDINVLSNASCTTNCLAPLAKVINDNFGLVEGLMTTIHSYTATQKTVDGPSAKDWRGGRTAAQNIIPSSTGAAKAVGKVIPALNGKLTGMSMRVPTANVSVVDLTCRIEKSATYEEIKAVIKKASENELKGILGYTEDDIVSTDLNGDDHSSIFDAKAGIALNPNFIKLVSWYDNEWGYSHRVVDLIAYIAKVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIP1</accession>
    <name>A0A1Q5UIP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIP1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="17037" checksum="A0BC63FA222F2C91" modified="2017-04-12" version="1">MEGWLGWLRSDPKSDEAFKNLERVENWLVVLRVVIIHSEDRTAAQTGLFGLLGDVRVQIVPVSEQARLSALFDLAERLDRQNQFAHRQNLERYSVEKYQEGLAHSVRYGLETNDEQTVSKFLKRMQPAVMFRLCTEMCNHSREEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJG9</accession>
    <name>A0A1Q5UJG9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJG9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJG9"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF22">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="39"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="252" mass="27570" checksum="B5ED8A98F4D149D1" modified="2017-04-12" version="1">MKTKKILIILSDADSFPIKKTSGPNSGKTVQQPSGFFLQELAKPLQKLLDAGHEVTFASPKGREPTADPNSETLLAYAGNFYERRREHDLIERMKKENGFSTPRPFSSISDAELATFAGIFIPGGHAPLQDLGEDPELGRILRYFNRENKPTAAICHGPYALLSTKKAGDGSFVYSGYKITCWSDAEEKMMETMLGGEIEKVESALRKEGAVMMEGMPEKVGGTTLHRELVTGGNPLAANALGDRFLKMISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJM0</accession>
    <name>A0A1Q5UJM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJM0"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="227" mass="26300" checksum="79FAEEED78477E14" modified="2017-04-12" version="1">MIRFIVTASAVITGGSAVYFYLFHQRLSSRIQHKSHRGKLSASSPKPIEIESVPETIFTEEYFALYDHSSKSVSRDALPKNIPTEGLFTKLVRRNMTAFTRFPQALMIRLISRTPEEQRSFKASHLSSLDFYEGDLVCGVYRVITRTKNKVEFEMKMKNMEFINGRLAISVRETESEVVFSSETLMWRRSDEAQAMPLEKPLLRWMHETAAWWLLDSGVKYLMELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK82</accession>
    <name>A0A1Q5UK82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Proteasome activator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1612</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UK82"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="376"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1355"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1872"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="908"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="933"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1960" mass="222398" checksum="616FB2C4D355518D" modified="2017-04-12" version="1">MDTSAPKAILTSDNFSHAQEISRATSPGGEPVVMNGDGEPKARVRPRTYPYFKYLPYQLEDETERDRTLREILNQLYISVEAGDFSPGAVHWTRELRGWLSLKFDPTRKERINLVKLYFELSLAPGIDPGVSERFASMFMLLTKRKHYLRPVKDLVLDWKPLYKELKAFVLPTESGLVHSTNLKRNVKTLTKMCAFSQLFFDPCELPAMLEEFLPHYTTSFSEGAFVVAGLINLLLPTSPPPAEREDLLPQTHLPTQFHLWSLVGRSKTFDTTYLDYLSRLARDSLPAGHIPFSEHGIFTKDQSALIFTAILRLLEIPVGQSTSPYSALVDISSGLGIMLDRDTRKHPVAHHIARWIVLSLSPACLESEDSILSQLEGLIQAVETFFHPSNSGSWTKTLSQLVYYLTDFFVMRWNREQSGEMEIPVERRLTEPLKRRFVLCLRDVIFMGIYAKSSTAMTFSLSTLQGLAYLEPHLILPGALQRIYPSLQGLVEVHRTTSSLRAMQVLSRVITRTRGYRCHMTTLLGLALPGIDANDLDKSLHALSFIQSACYNIPMVDMTQGREDVNCNMLALQWITGEMERMEEQGTDLQLNYDTELDDETEELILRSSTCGFGDFTISFLGRVFTLLENLPDVTRVRNGSPEENIVNTLPATFMPLLASLSPEYYDIALSKIVDFVSNHVIHQARDAMAFICNALCKVNPEKALKRFIPVLIQAIRTEIEENGAGSTRTTGTDVLPRDRGLVWNVSMLSMCVVHVGDAVLAHRQELFDIAVYMQQKCRGIPTVHISNFIHHLLLNLTGTYTSDYSLYEKEDTKEGIQPTHWSYKPDVQNLNINWHVPKREELEFAVEVFKNQAESALKHLSGLTNETSSIKRDGSGKDWSDEVTRNLVLLRLLLSGISVLFNPKAASKSSEASDTNEVEMEDDSTVSNGVGDEDPEAALDSSDESAIKENFSYPTGYPLEEEDVLYTTIHEIRERAGFVLHDVHRFLSDKQEDDVPCFGALYSAYRSWFVDVGIERSAHVLDRVTRLLAADIHPYKMSGIRKDYPRALLVRRANVYHLQRLRHNAAPRPRSKLDEILLFDLAESCVSLYTETRRNAQNAGESALKSVWGARTLIIPPLLKALQKGVKENDHARIKGALFSLLLSSVAKTVGRNWKYTPALIRTFIDASAVDKPSVQKICSSAVFQIMDYGRAMERMAILDQKIIEAIAPSDDVNGEIEQKRKVINNKRALIEKKKADLAEELVNLARVSHWKIASRAATIVITMGLRFDYIASDNLIELVTLGSIDDHPGLRGMYSQALIALFTMIDVRAICTHEYKNYILGHQRFPSKIKVATRPDEKDWTQEYLASFAKPDAEYYVDHDFPGWLVWGKTMPAYKSNIGRDIEYDDVEWNVRTQMGKLFTREWFSKFFMYLKQEPRDPSADKFRMSCAMMLLYAFELMLRDGLTAASFQDIQEEIQAVFEDGSDKHQHRATAEILGALISSVTDTSVENRALVWEYSFPIVRKIFTDGLTPENSGYWTTFLHMILQCRDPRRAWPLVDWLASFRLDMSTNAAFKESSKINLLHQCIIDAGWHFQLEKPIVENFLGHLDHPYKGVREAMGQTLATIYRTRYHESYPDLKHLLEDQKAASSVGTYPYQPSDDFSKILRGVFDQIEQWRQARTPGQQTPSSYTSGSKTVLLWLDSTLSSHECTQLVPFFPDVFTAQLLHMMDVKEDPELQSLAYHVFRHLPNIPYPAEKNSDFVQTLIRIGQTSPSWHQRLRVMINIQIIYFRRLFLLDPADRDKLFECIASMLEDPQHEVRAGASATLSGMVRCSPILLRDKMVHRFQERFTRLLADNPLPKKPRNIRSGISSAVSSGAGTPTPEHNRLIIVRHGAVLGLGALIQAFPYNSPPPRWMPEALTTLSTRAANDPGVVGSSVKSIISEFKKTRQDTWHIDAKAFTPDQLEDLSGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX5</accession>
    <name>A0A1Q5UKX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_1212</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="162"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="18">
        <location>
            <begin position="1120"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="845"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="975"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1004"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1027"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1053"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1067"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1084"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1118"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1146"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP13112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1260" mass="135691" checksum="63B47AC5A598C942" modified="2017-04-12" version="1">MVRLREIPRTATFAWSPGAASPLIATGTRAGAVDVDFSNKTCLELWDLSLERQDASEELQPVVKIDTDSGFNDLAWADFDDTKRGVIAGGLENGSLDLWNADKLLAGSSDSLISRTTEHSGAIKALQFNPKHSNLLATGGAKGELFISDLNNVENPFRLGTTTARTDDIECLDWNKKVAHILVTGSSAGFVTVWDVKTKKESLTLNNMGRKAVSAVAWDPAKPTKLITATPLESDPLIYVWDLRNSHAPERTLKGHESGVLSLSWCDQDPDLMLSSGKDNRNICWNPQTGEAYGEFPVVTNWTFQTRWNPHNPNFFATASFDGRISIQTLQNTKDNSQAIADHNQALDGEDFFAKAQIQPQVSKFSLPKPPKWLERPCGASFGFGGRVVSIGLSEKGSRASKVRITPFEVDSSVGNATESFETALKEGDLRSLCETRAAGASTEEEKADWKVFQALLSENPRKTLVEYLGFQDSADEAADSLSKLGLGKKEDEETNGVAEKPKSSAKKHKRLQSMFDATPDSDNFLTELAASKGAQTNNPFQIFNGSESPAEQKITRALLLGEFEKALDVALAEDRMSDAFMIAICGGQKCIEKAQEYYFSKQTGGPNYMRLLASIVGKNLWDVVHNADLSNWKEVMAALCTFADEKEFPDLCDALGDRLEEQVRDSGDKTARKDASFCFLAGSKLEKAVSIWVEELRENEQRGIESDTDNSTFSIHVRALQGLIEKVTIFRQVTNFQDEEKNKDSDWRLSTLYEKYIEYADVVATHGRLQVAQKYLDLVPAKHPEAEVARNRINLAMRQAPQKAQAASTAKSFKPLPQQPNIYQPQQTFSPVAPAIGAQTSYAPPTAAVPPAQPPANAFAPPTASQSQPANPYASIGGAARSGYTPAGYQPTQGMQAPAYGPQSTFGNQSAGTGVVPPPPRAGTQSPGNTITTYTTATGLDAWNDLPEGFAKKAPTPRRGTPVAAATISSPFPGQSPPLAQGPPPPGPPQRAPSVPPPPKAGAPPRVTSPLASSMAGPSPPPPVNPYASLPQSPPTSTMSPPASIHRGPSPYNAPPSVPPPTNRYAPNPAAQAPGPQLQARPPVAPPPQGGPSPYAPQAAAPPPVASPYAPSGPAVAQPPPMGSAVPPPPQRSRPGTAQSQRAAAPPPPATPKYPPGDRSHIPPNAMPVYEILSSDMQRVKARAPTSFKAQVDDAERRLNILFDHLNNEDLIKPNTVEDLANLARAIQSKDYETARVIHLDIMTNRTEECGNWMVGVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULX1</accession>
    <name>A0A1Q5ULX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULX1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="11668" checksum="46A7AD0162BAD481" modified="2017-04-12" version="1">MGKSRNSQRPEIAGGKPNSHIQYPVLDHGVLPFWVCNPPKTIHIASTFGTWFPHIQIVVQIVVPHWLRPGMALSAEWMPMQRFAEVSPIRTAGLHGVAPTRVVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULY9</accession>
    <name>A0A1Q5ULY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULY9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="19571" checksum="B5DB364D0452D372" modified="2017-04-12" version="1">MEAAAPYAISATDRSGLIVIVETLFMSWMIMVSLIRLYMRLAINGPVQVDDLVVFAGSILAIAHVGTVMNAISHGLGRSQDDSSSWDLKRAGEGVYAANLLFLAGHGAAKISICLLLKRLGRQRKYLLCSNILVGMVTAWTIASILAVALSCFPQYQLSMVQHCGNIVGYAFHLTKRRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMG6</accession>
    <name>A0A1Q5UMG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMG6"/>
    <dbReference type="OrthoDB" id="4349137at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="133" mass="14256" checksum="2664A5007F8E6888" modified="2017-04-12" version="1">MDSKLVNLSNGPGYALWYGKQASLETNLVIVEAKQKDNLGAAEPQVLAYIGLVHSGRLEQGKQDTTVYGIASDSSTFVFYRISEGSKWCNKPKIWGQSKAGNLNIIGCLGSIFSEASALRAIPDGLEKPPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UML7</accession>
    <name>A0A1Q5UML7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UML7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UML7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="401"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="587" mass="66869" checksum="715C145C75B86B61" modified="2017-04-12" version="1">MVGNTNATMVEETICNITTPESESAEEIDIEYAIRGSTCGVRNLYQTEPDEDGETSRTTKLPVKMIESVKTDESAQFALILRYTKCYDGREEPDYLLGPGPKRASEELLGEIPYDGYAGVTTPLKRLEFKRPLRPLVYRWEKFVKVWEEEELDSTAKEHADLFYKIFEEELKDTLEHKKDLIRNRVITHPLVWILFEPGDMVISSSNAPRGYLFSSAQLRNRSNDWVLTCKHINFNGKRFGYKDQDFFVDAFVGTMPITSLPVYPLKYHTEKDDLQKTLIAQGKRWEEHKGYHYRQYEGTALEPQRKAARNNTMSRVVLSSTPKPSRMITSDTVYGYSLIDKEWLEFSLRGVSEIEWNTHAFESLVLPQEQEGLKDLLLAVANAQSKQLDNFDDVVRGKGRGIILQLSGPPGVGKTLTADSVAEVMQVPLYAMSAGDLGTHAEVVEQKLQEILRIVPKWGAVLLDEADVFMEALSSADLERNELVSIFLRVLEYYEGILFLTTNRAEHIDPASRRHIWSQFLGRSANVAAFSDEQLDQLAVPQMNGRQIKNTLKTASLLAWSQEKELEFQHVQVVLNLRNSNALKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMP4</accession>
    <name>A0A1Q5UMP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMP4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMP4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="2"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="389" mass="43291" checksum="3329B0581F772DCA" modified="2017-04-12" version="1">MIFVQMNYRVGAFGFLASEKLRENGNLNVGLLDQQKALEWARKNIHLFGGDPEHIVIHGTSAGGGSVAYHLTAYGGEKEKLFVGAIAESPFLPTHRTVAESEFQYQRFVEGTGCGDHEDALACLRSQDTATLQSADVASRFPGTSITPLWYFLPVIDGTFAPDQLYTLFEQGRVTRVPVMVGDDNDEGTYFTPNASTSAEFLDFMQANYPRLTSTDLQIINETYPPGALMVDHAPYFAPAAQAYGESTFTCPGNEISSSIAKYFHPSKAWNYRYNVWDADYQNAGLGVPHVTEKPAVWGPGYAGACDNCSYLTYNKPMVPIVMDYWISFILSLDPNTYRDSSAPEWKPWGTAGGQRMRFQLDATDMEPVPDDQKHRCMVWKHLAGMMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN89</accession>
    <name>A0A1Q5UN89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN89"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="31873" checksum="71D58DB8099679FB" modified="2017-04-12" version="1">MASVQPGHSHGDLVDDDSLLDDDLIEADHDIEADDPLHTSDTAPLRGNIASDSGRGSRVDGYGNYLTSSIPGEDRRATQNTIDETVWATLSRDLFAVWEKMRQVLWPKYLLGGMLQRGGGGIAGAAERGEASGFGRNLRGIVGRWPDADVVLQGGMSEGLRDWDLWGPLVFCLVLSLFLSVAKGDQASLVFSGVFCIVWIGEAAVTLQIKLLGGKISFFQSICIIGYTLFPLVIAALLSALGLPTIARIPVYLVLVAWSLAAGVSILGGSGVVRNRVSIAVYPLFVFYIAIGCLCFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP42</accession>
    <name>A0A1Q5UP42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP42"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="19885" checksum="05B503C8F96B84FB" modified="2017-04-12" version="1">MDRPFSIEDEDIAVLDCAAGRDPAAKYPAVHIMRLSCRAMIEILKIKGSVTVEPNLVRSASSIENDFIKGCVDYIEEEYQRSDRGELGGFVEAYDIFNAGVVIVCLAAGKPSFPLRDANIVNKCTALLTLLGERFSGLRVFRRVLWALSGLVRGESVNDPIIRELPPVIPGGIRELISGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP93</accession>
    <name>A0A1Q5UP93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_55</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP93"/>
    <dbReference type="OrthoDB" id="2583188at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012095409" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="40206" checksum="BC37F57B9E74DAD6" modified="2017-04-12" version="1">MLTLFLISTLAQAAVAAPGLIQKRGASNPVVKGTPQVVGILADSSLNRDSCGSSVFGGRALWVCRDTQHYDANGIPNLPIFTSSASWTDLVSGGAGGGTNLNMYGNNNDQSFYPLVPGNCNDNQAGVCSDGTRYPLWANAPPLVTVSDSSKTVGYTWINNIHISGLTNLVADPSTTLYRVTYTSGAAGLPQVEIVNSAFWAENEIPYGNYGGVVQGSTAYLWGQDSNKNVALARVPVGSIEDASQYEFYVNRVWTSNKPTLGNTAAKIENVSAGGQGTYYYSQPWQSYVWIGQAGISVSADFYITTAPAPEGPWIQPIHFYSGVNGNFSLGAYSLQANPGLSPADQNEIYLTYTKTDVVGDNVALYTTPLILVQWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPC0</accession>
    <name>A0A1Q5UPC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPC0"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="36533" checksum="28CAFBACAE6C9E3B" modified="2017-04-12" version="1">MNSTICVIEANPDVSGTGIRASIYALCLGGTLVSYFLRVFSPGEDEEEFSRGVSSALGMQGLALLCTAIYQTFRSELTLFHAICVVHLLALLGLNLISKGRYAGFGPWRLWCFVAIQVIALGAFIAFNVYLWVTAPHFGSQPACNPDTVYVVFGVSISATSPVFRYIILGTLGASAAGFILVFTCLLPCLCGAWIRRRRDPLAGRNVGTGRHGNCTWNWFVQTSTSTDDQGNSQREELSGQALLNFTLNRAAYCGLCIYLIVSLEQTIQRNTLDPQEKGWTFGQVIAIFLLLGVANELLNVVLASWDRRIGHEAGAQELVQVRPASSSTASRNSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPM5</accession>
    <name>A0A1Q5UPM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-reducing end alpha-L-arabinofuranosidase BoGH43A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_14040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPM5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18833">
        <property type="entry name" value="GH43_PcXyl-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF17">
        <property type="entry name" value="BETA-XYLOSIDASE C-TERMINAL CONCANAVALIN A-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384573" evidence="7">
        <location>
            <begin position="22"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="354"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="583" mass="64189" checksum="CCF3423339B51633" modified="2017-04-12" version="1">MNLLLLLAGLVLQIATKQAYALNTTYNNPILPGWHSDPSCTFVSEWNNTFFCTTSSFLAFPGCPVFASTDLVHWDLISNALSRPAQLPQIQTSTNAQTLGIFASTLRFRDGTFYLITAWLDTDNDGVQIVLFTTTNPYDENSWTNAFQIQNPLSAIDPDIFWDDDGNVIMAYSGSPIKASYIDLATGNAGEPFDLWNGTGYNYQEGPHLYKKDGYYYLLIAEGGTELHHSSTIARSKSIKGPWESSPHNPLASARYTDRYFQTVGHSDLFQDAAGNWWGVALATRAGPVLYNETIYPMGRESVLYPVSWPKGDWPVADPVMGEMSGPLPPKSSKKSSVPTFMGEPDIVDFVPGSSIPKHWVFWRAPAKPESFTISPPGHPNTLRLTASKANLTGDASFKALDGLTLLARRQTNTLFEFSVDVHPGFYKTQGDEIGVTAFLHQDHHIDLGIVFMGGSPHSKGTLSFRCRATDSDATNFTVPSPVVTPVPSSWLSETIRLYIRAENSTHYQLSAAPAAWPHDSRLLATFTGALISGPDVFTGNLLGVYATTNGGNQTMQGYVSRWRYTPVAQQIDYDDFVRSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPT6</accession>
    <name>A0A1Q5UPT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPT6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPT6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="396" mass="44883" checksum="BBE93C4E493F3C29" modified="2017-04-12" version="1">MSTTMFTNHYDVLGVSRHASIEEIKVSWRKFALKYHPDKTRGAKTYTEMFQKGQEAIEILRDPSRRYKYDKELEAHSSHPWVSSTGDHPPPQTSSVDSQSMNSHYHHRNWTGHQNRQNGAKYGGRSEISSGRYRSEAEMEMIFETVRRHERARTEALRQRHAERLKLSQKPSDKMPSRTFTDGEMILTHTLISKVKSRKMSHTRRRSELKPAVTSNGTSSELGGVLLADFETPNDDEKTYTPDTLRSSPPVPKCDLAIPSSSFNSVNPDQFAGGSHNPVINNETQWPLRAFIPYDKAKLDDPRGRYTVDDMYDELHGLVMESVYSWLKTTDLAGSNTSLNTAADAGSTCPHLGLWHKEIGHSNVTIAISGSPFHLDLPGLRSEEMFTKQVRGLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQJ6</accession>
    <name>A0A1Q5UQJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQJ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="5">
        <location>
            <begin position="3"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="235" mass="25320" checksum="9FF195B2FD6A1CA1" modified="2017-04-12" version="1">MSAKFPNAKRFSIEGVESQVPALKAIIDASAENGVREIIFPCCHRGKLNVLSNVARKPNQLIFSEFSADSKSRHQISGDVKDHLGMNYERKTPTGKKIHVSILPNPSHLESQNTLGQGMARAVQHQNGGDRKSTMVLNSHTDASFSGQGVIYETLGLSGLKSYETGGTVHLIINNQVGFTTNPESARASLYATDIAKTINAPIFHVNADDVEAVVFPASLLLIIVPSLAKTAGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR40</accession>
    <name>A0A1Q5UR40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR40"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="56305" checksum="EF8BCB64A1E9D81B" modified="2017-04-12" version="1">MPSKKFEMGATVDHEELPSDRNAASDTLEMKEKADLLAADPGIEIDAATNKRLFWKITRRILVIQVITYFCQSLDKGILNYASIMGIKTDAHLVGQEYSWLGTILYIGILAGEYPQNFLLQKFPLAKMLSINVFLWGAVVACSAASTRFGSLMAVRFLLGFFESCVQPAMMLLTAMWYKREEQSVLNALWYCMSGVSLMIGGLLAFGVSHFKNGPIKNWQLLFLILGLATCVWSFFIATLLPDSPLTAKCFSEEDKRLMIERVRENETGIQNREYKRYQIVEALKDPFVWCCVLLITVANLVIGGLGVFSNLIIIQFGFSLLQTQLLNIAQGAWTILIMLGSAWASQRFQQTCFVMILCAVPALVGTIVILVVTPTASNAGGMLIAFYCTQFFLAEGNMIISLITRNVAGQTKKGITMTMVFVGWAVGNLIAPQIFQSKDAPRYLHGFLTHIVVYAVYVALVVLTRIILMARNRSKIQGSTEISHDLAFQDLTDRENPNFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URK4</accession>
    <name>A0A1Q5URK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384542" description="Xylanolytic transcriptional activator regulatory domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="330" mass="37583" checksum="AF390A59CCFF2F18" modified="2017-04-12" version="1">MSRCWMFTALASKVIIALNYHNITDTVPRNDVEEEIHACVYTCYYFDKTLSLLLLRPPSLPELKVEPARLIHLDPEMPTTAMITGIVEFAHLKNTLPNILLDTKEMGDDLRQFAKANASIGKLCALFAKFLDLCAPLIKSNPPAGASEQFNASQNGNIPIERRFPGQLKSAYPDVLQQDVRQVHNALPSPLPSSETFGVPPSVEGWDDSLIWELFDNQPSLGWADSELWNAMTQLDSRQNVQPFPKKQKSDKSVAERELADLKTWRKAQKELFDRYIKAKRDDRWLKWAQSIIEIHIQLAKTVQREQFLEEKPPASNKGMGTLYPRVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMQ3</accession>
    <name>A0A1Q5SMQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENP-B protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMQ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMQ3"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041188">
        <property type="entry name" value="HTH_ABP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18107">
        <property type="entry name" value="HTH_ABP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO89268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="566" mass="65127" checksum="5F26565A8476E034" modified="2017-04-12" version="1">MQDSTSPSPSLPPAPSVRSSVILSAKLPYVKRSNATISDAQRKALRIFASETHPKPTQKACAAWFHEKFGRIIDRTTVSRTLSSQYSYLDNGEAGTKSGKSTAHWPLLDEALFQWQQRHTEKGFPITGPLIRLKAEEYWKKIPMYQDQTMPAFSDGWLTGFKRRYSIRWHTFHGEAASVPDSIHHEMKAIQVICDEYAPEDIYNMDETGLYWRRMPNGGLASEGRPGQKRDKTRITIVVASNTTGSDRLPLWIIGTAKTPHALRGVNMASIGCKWRYNKKAWMRHEIMEQWLRTFYLRIGRQRRVLLLMDNFSAHLMALKKALPPSNIRIVFFPANATSIYQPLDQGIIQNLKHYYRKSWMYWMISMLDRGIDPRERMSLNYTLRWLTQAWRTKVTNETIQNCYIKSTVVPGCRLSRQDQADQDQTESNLLDPELKPLYNQVVEKLAFQPDADEILPFDEFLNPSDENVDTTEPELDDIIINLGGEDIDDDLPDPDEEYIFGPKPEVPSDTVILRHLSDLSLWAAHREGCTEEHMSSIEALSKAFKKLEVDGKREKTLMEMGFKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNP3</accession>
    <name>A0A1Q5SNP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNP3"/>
    <dbReference type="OrthoDB" id="4363173at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="130" mass="14667" checksum="433B4EFD3C21B23A" modified="2017-04-12" version="1">MPPAKKKPAPRPKPAAPVQSVFQGGSFLVDAQAEEEADHEIQPTLSMSDLDLDVSYVGMFQPAPQGERDQTGSQQFFQSPAGWTGHDNDLDPNDFEDQIKRCHERISENFMTQIYSPRLAAYERLRTEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQX9</accession>
    <name>A0A1Q5SQX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQX9"/>
    <dbReference type="OrthoDB" id="10634802at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14925" checksum="DCF2CF52201BA0B6" modified="2017-04-12" version="1">MAEVLAVAVASGDNQPSATSEQRVWDNIHRHEFRVVVLCLEKNPEAEQATAEEVALCHNLGEIAESEIPENECNKTWARRKLVFMYWVFCGTKNAWEWDVEKIREERRRDQELYRFSDSGELSPKSRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVK4</accession>
    <name>A0A1Q5SVK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="56705" checksum="50226629F5B16F09" modified="2017-04-12" version="1">MAEAERPAFQIIVLGPNGGPREDSVTGLLVRSTSMNWSPDSVVAVDAGTLLAGIIRVLKNFLPDSKDDEGVMTAGPFKGLQLPAQSAEANAAHIFREIIGAVLITHPHLDHISGLAINTPILEAGNGPKPVAALPSVLSAIKNHMFNDIIWPNLSDEDGGAGLLTYQRLVEGGNTRFGSGESRGYVRACNGLLTKCLGVSHGRCKQRYHPESAAHHRIGSAVFPSDQLMLPSRAVSISMEHADGSFYSPARSPRLLPANAKEPMMATVESSAFFLRDHRTGKEIIVFGDLEPDTISLEPRNKRVWEAAAPKVHAGTLRAIFIECSFSDSIDDAYLYGHLCPRHMIAELNVLAAKVMALRDPVPAPDKKRKRQNTSFGDNVGSPVSPRTKRGSNPSIEKESKVEPRSGEFYVPDLSESFNDGTDSKDVDLPNIVSWADADPLPLTGLSVRSTHKREDWAYDCLSLVPECLVDCFQVPGWNDARATGGDLVAWESRVASDPWAGCHGTQVVLSVNASELKSNEAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ40</accession>
    <name>A0A1Q5SZ40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ40"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ40"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="487" mass="50648" checksum="F8C971B2969FC912" modified="2017-04-12" version="1">MNGENIPGTITTPAMMSHQAMIHQAMILTKQRTGGSYRQGFHGHGPQSQPQPSTAMDAEWTMVPVELSILDPVHGTSSAYCGLAWSMEDSGKVSMSAAPTRFTYLFKLGASCGSTWLLFFGTTVVRIDSPTGRIVTKRRDECTLWAQKYDTMRGVSILILYAASLASGSVLPRDMAGNVGIVARGGGGGDEGGWGGGGDDGGWGGGDDNGHGGHGGHGGGHHTTAETTPCETDTPTPPPPTSTPCETETPPPPPTSTPCETTTTTPSPTSTPYYDYYSISNLYSLRDYDYYFVSNLYSLRDYDHHTYVYSITTPTGPPPTSTPCETTTTPTGPPPTSTPCETETTTPPPESTTTITTVYTTTTCPVSWTTVVTGSSTITQPVTSTSTITVTSVITCSEGCPHPTSVPGTTVVIPPTTAPVVPPTNPAPTNPAPVQSSPAASPVTSAVQTTAPVAPATSSPAFNGASSQFKRSLTGFIPALAVVLALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0R5</accession>
    <name>A0A1Q5T0R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein transport protein sec39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0R5"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="13"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="936" mass="103047" checksum="9621F2452FA67269" modified="2017-04-12" version="1">MAPLEGLTDARAILLATHYCTAGDVTDLPALQAHYPHCFPLERLLRIILTYLPESTEPSAYVPVLQQLTETSPLGFGDRDIDISAVKDLSEAAARKRVRKLRLRPLKREDEEEEVESADLLTQFLIHRAYLIDTETALQPLILGLLLPFYEQRPVIRTWLISSLLPALRLNYEYYPNREETISLETLESMDDQTAINILLSITGAEGNNMDLVNNLRGLIGPWLYGGNRAKRRRLNESAHQNSISFVQGTAKPPPTELAGWEYVNEWLLSRSLVDRSSVVGAFTNWNGPGDIDLGGYNDEGSHISPEKMKELLNRYGQSGLSVVYAHADSSQAALDGSFQVVARVARLLELEEFSYLNSSDSALPSVDYDTEQISSTSRASLLQNGLLAHANALTNPSPSSISFLSALLLSLRILTQLGHILPCRAAANICLHSNEEMQLAELKSVVSSAVKQQRSRQNWELVRLQLLWLRDWQAEHSDNGWDEPSTHHGLFWRISRDTVETEILKALLSAREYQLAVDLYTQPESSLSTTQVEAAVVEAIFAAYDNASNGNRTRGGMKKAYGILQAFQPHFQISIQLKQINSLIAATHALSFYSLTLQHGVPFEPVSIRVHHDPLSLVEKVLDQNAKSYTKLDDLLSIGRNLVKAGLPTHLSSSEHESHTSQEQLSEEDALVTAERRITSLAISSALTSNDFGTAYSYILTRLPPPSMLPTSSSLLTTTVPDDISWRAVYNAGRYRSASPNTSATLQSQITHLSQRMELLSLALTLVPSPDPLPEILGAWRRCDEEMSSLRAREQQEEDVWDAKGDSLSTVPGGFGPTDSERDAFDTAQQRAARRARARAAMPHSHPHEAPMGLFEVARGAAIALHKNAFPLRGAADASRIPAGAGAAGSGDAERSFSPDQGEGRVRKRDMVSNMVTGGLASGIGWVLGAEPVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T107</accession>
    <name>A0A1Q5T107_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RutC family protein YjgH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T107"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T107"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23156" checksum="F8C04D242EFE415E" modified="2017-04-12" version="1">MTVLPLANDLGLEVDAHCSRKGTQCVADTIRNYNGPGNILIAWRHKNMGEIQELLGSYDPLEYPEDRPSSIFIMCTLQFFNYPGTEANSESFHYSQAVKIGTTVKTSGQGGWDESGNITSNIEEQVAIAFENVDKALKEVDSRLSWENVYAVRSYHINVEETFDLVTSKFKKILPNHRPIWTCVEIGKLGIEGMVIEIEVEAYCPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T164</accession>
    <name>A0A1Q5T164_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T164"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T164"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="206" mass="22996" checksum="5B9047EF722248F5" modified="2017-04-12" version="1">MQVQLPYDVGAFNKLPSLNEAHTQFMAMNGLKVLEEFLHSLFLRYQMTEKFGMTLLHSHFVLNDHEILVEANGTSTPWDLRGADPTPTGFAKYDGAIKPSSWMVTDDHLRAFEFYFDPNTGTPGIDPSVSFVEDLSTILKANNLSNVLGLYQIADASTGQIEVTEGRANVTFPFDKVAHPDVINSDNPPDHPNEPTTEYIPFDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T240</accession>
    <name>A0A1Q5T240_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T240"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T240"/>
    <dbReference type="OrthoDB" id="5367584at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024312">
        <property type="entry name" value="TACC_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12709">
        <property type="entry name" value="Fungal_TACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="893"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121494" checksum="FEFF657CCBE1BA3B" modified="2017-04-12" version="1">MSNPLSPLSSSYQNVRARSPMAGSSPFLTKTLDAPSNTESALPSSPLKQAWTDRETDTDARSPSPYKNHENENENYFPNDHCRDTHDNDEYDDQDQEELASSPFRYDTRDDTVDFQNMREYTGPQRPFPGASARHQFPIEEEDEPPSSPFRADARDENEEEAIDEQIDSYGLREVQPMSPGLDKRLAFEDPASSPFRADVRDETVDFDRLREMQGPASPGFDEQDEQSVSSPFRPEVQEETVDFEKARRESLGKRQSVGKMVQAAPVEIGSSPYRPEAKDDTVSSHVSRGLQRESIGGQPTQSPGGPRSPFRHDRDDTVGSRKSLIMQRESFGKRMSVGRATQNAPVDAGGSPLRRASDAKDDTVSSHASRALQRESFGKSSQSPIGSRNSSFRHDEKDDTISSQKLRSAPRVSLGVDDHRSSTTARKRSFDQTPQDHEADSQNNERCKKGMTSRVEAPEIHIDLEEGESSVIHNQSFVSAGSATYDRSTIANSMMEDKRNEGMSTVLHDDEETGKENQRLERPDEHSILGEDDHDPMDDTGLSNFSVLPDMTSFANLRAQSPLKSMRGSIGPSPGPSADVYRRSLAPSTPGTARRSYRASAMFDTGSQVGSPTPRRRGSRDVGNPRESSNLLDFTDQMNFLPRQSMQSSRYSPARRSPMRPMRQSMRSPSKMSSLLDFDIPPAPTPRSLPSITPRELESLKSSFMSEISSLKATLSGKEAEVASLKQAVSDAERRVGEALEEARHEAARKDELEMEQAEWDRRGKEMETVLTSVRDELEDGERERERLTRKVDEGEKAKEQLEGRIVELETQLSSARSASASASQSSSNAGSRQASQSAETTAREVQEAVEKVARELHTLYKSKHETKVAALKKSYEARWEKRLREVERKLAAATQDNDRLRDERDAAQSESMAAANASMIARENDEHEAEKRVFEAQVKGLQHEMAALKEDSERLRSELKSERAEKGELVAAVDEWLAMQQGQAQVQPQEREREREREPSVSSAGHYEEEYYYQSTGEPVESFNRSIGRSGSASSGIRPPPATNEKRIPRFGAAPGGHSRGNSGGKSGIAVFTPGRGGIMSSIERMGRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2P8</accession>
    <name>A0A1Q5T2P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2P8"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012999414" evidence="3">
        <location>
            <begin position="32"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="38722" checksum="C2EB09A87F4DAB45" modified="2017-04-12" version="1">MRLSRRGLGKAQPSFIFLLVLLLAITARVAAEPADAKSTSTTTDAAQTTTADPSSTTSSVTSTSSSSSSTSTTKSTSSTTSSSSTTSTTMSTTSTTSSSSTSSTSSTSSTTSSVSTTTDSTSSSSTSTSGPVVTVPPTANAPYMQTTNVPEGTVFIAVGAILGLIGLAVLAWRGMVAWSVNRSVRRAALAQTSDKKRLARRGGGRKRSHGVYAATAGNDVSLDKLGAATRASYKPSKRGPSTNSGLFFSPTAGGAGSHHSLNNAGNRGSSYLPAGYYAAAGTSTPVRDASGSQTNIYSPTAGLSSPTAFHAGSSPSLPAVGGYPEMPHTRHSHLGASTSSLNLSQAPQGRAPSAYLEDLFESHTSPRHSESGLGRQPDSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T323</accession>
    <name>A0A1Q5T323_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T323"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="14472" checksum="26C5691AAE404D37" modified="2017-04-12" version="1">MPTLEYASSFANLPAVSEDYSAPQEYQLKAVDPLEEFDDFDTWLEDVIQTLRPQNLHRLIDAYVKRPPKTSPEVSRWVKTSRDIRYWMYQSVCKDINKLVLARRFRCEFADEYFELLKQVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T400</accession>
    <name>A0A1Q5T400_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T400"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T400"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="383" mass="43065" checksum="3B55CF5A3D633353" modified="2017-04-12" version="1">MEGLFFNVNGGFVEGIVRGYRNSLLTGQNYSNLTQCETIDDVKLQLGPAYGDFLATLPPNPSTSALAGKMTDKLVSEFRYLVAQSVGSTAKFLEYLTYGYMIDNIALLITGTLHERDTRELLERCHPLGWFETLPVLCVATNIEELYNSVLIETPLAPYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYNFVQTHPDFSGPTQEIMSEILQFEADRRAINITLNSFGTELSKQERRKLYPEFGNLYPEGSLMLSRAEDVEGVALAVSAVSDYKSFFDAVGLSQGGSGLGGMGGGPADGKSLEDLFYQKEMEMSKFVFTRQFTPAVVYAWMKLKEQVSTIYMNNPFLGITKANNYQEIRNVTWISECIAQNQKERIGNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4C7</accession>
    <name>A0A1Q5T4C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4C7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4C7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44996" checksum="EA239446133DD553" modified="2017-04-12" version="1">MSDTQSTDDVIVINPDGDVLLFTRDECDETVDYDESPKYTKFLLSSKHVALASAYFRAQFSTNWREGRAVTVNGAVELYLSTTEHDSKTMEILLNAIHGSQWQIPHPVSCGRLWKVALATDYFLCREALQTWSLWCCQQLVRLFPTELTDWSWELIYITYIFRWKSLFPHLTQLTQQKCLASAHLGPSPIPKWILEVIFGKRNAYLKQCFDLLDLQIAYLGAQQIHCTFKCNAKKAGALMKYSGQFKTPSTEALSGEEPAVTTSACSPFSFCQAAKEWENPNHNSRTLNTASKVTRSWRPSPRTPRRSPCADESLLGDQLLEHIAQMEEKLNGISHVPEWGLEFKITIRHTIRRENPSRRTPHTSPTMEVAKSAFRRYSTPAAVTDPAKRKSRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5R2</accession>
    <name>A0A1Q5T5R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5R2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="33936" checksum="9887E5FE0C3410BA" modified="2017-04-12" version="1">MATESTHRPRAATTSIPVMGPPSSIPRHSQGSGQAHRSPVLYQGSPPLGMNDHDINSTAQGKPCPETCVVHITKLTQVGPLRHPKPITPSDLHLVLEKEQEAMVNRLTRELSLLRQQTASVASTASSTSTMNDPIDGFHTSPSLGSSTHTHSSRRQRSSSSLSSHTAAQSSQAASVTGIAPSRETSIPSRSNDTSHPRTVRSREPSLTSRRPSIGSIPSHPQYSHGDQFTQYGSPSIYPHRNSVSQTHLGLSSNPLSRYEEAVLHKSELEQIKRENEQLRKRVRELENVLKKQRDGEPMTPTETPPPFGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T628</accession>
    <name>A0A1Q5T628_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T628"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T628"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO95662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="53080" checksum="A2161C63EA902AC0" modified="2017-04-12" version="1">MDARKRSPSNSPTPDTVFLEACDVYFRHCHNKPYGFFNAELFQQKAAKNQIPLHLRLALIATATRYSSRSQWRERKQSTIDGYARCSWELIVTSQNGLDDTDDVTVIQALALLAVIDATDENHRDTSLRPGMFGISIALVSVLGRTIKCMMNSENNPEKPWQSQSEYRRIHSDLEFLKELAVNNSPVLAAPGQARPQDQMQDRDRERIAHMVLSHTLYHLSHCILSHPYLLSLKIQSVPSSDMPPSWLEETRATCLVHAGSLITVLVEAKAAGYMPVPSVYSYCILVASTIHALYLHSDDIAVSHSSAEYLKTSLDYLCEVSELWTNAQMMANALKSFALQCSRYTTLLLREKPLVDELTPTESAVLRSVIDYWAMMDPHNPVFDVAAKGPDGLLLDLDLPGIDIGPGYLTPPTHGAGAAGGISLGVEMSHSAGQKGGGGDSVDPDILIQWPVSIMSPMASDDGRSPRWDWDSELNAMND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T660</accession>
    <name>A0A1Q5T660_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T660"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T660"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="197"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="665"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="826" mass="90572" checksum="47E888F3C84D508B" modified="2017-04-12" version="1">MAVSQPPIQANGHTLSPSPSSSSGQLSPAIEPPRTDVFNASSVAEIKAALSRLHSQEASVTARLDALVMSQKDLSRELGRLDLMRAHIGTQTNTTRSISHGMLSEAASTAERISSAVRRLDLEQARVKATLEVVEQVAELKACALGVAGSMGASQDWETAASYLHRAAQVPPAVVNGTFAAEMVPTAEVPDPPSVTLDNAAESLCGLFLREFDKAVKENDGAKITRFFKLFPLIGRSEVGLDVYGRYVCQGVAARARSNLNADYGSQAKDGFFYANALTKLFEHMAQIIDGHGGLVERHYGPRKMGRVIERLQVEADVQGGIILDTWSDERHVDRKLMDIKSYAFTFLVQSFLPAQRAGHPPAAGVTAPTEDEGVDMKEIDGILNEMAIMLGRWSLYCRFLADTCNAPGDDQDQKDDERFALPAFLQESSLARKVNDKLVSPFNAMTTFFFRRSVEKAFQLDESPSGLTLNLQRPLKADPPHITSAVDDIMYIVNKVLQQSLATSQEAVVTNVVPTLSRVLGSDFIGMTQRKMRDECYPRAPVQGAQPPEQTIVAFLVQINNLDLGVDYIRRIVQNNSGSKQPLPSSTEGTTPDQSTLVTEHLRSIFPAPSSALHVAQTLHSLATSFEAKVADLLSDGIQVVFNNVIKHRLRPLLADAFRDIEYHPSDTSDPTPHDDYDPADGSSKELVRPRFAAGWTDLLLPLARILTVPAFDRLLTVTVAYFARLLEKRLWSYQGRINALGAARLERDVAGIVNAAADVGYGAGAGAPGRYRHREAFARCVQMTLVMGMDEDEWDEVLRGEEAAEVVEKLSREERIFPINMYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6R3</accession>
    <name>A0A1Q5T6R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6R3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6R3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="20516" checksum="B3B17AFA74E75141" modified="2017-04-12" version="1">MNAKVHLAYLQIHFQIYLVLGEDSSSPIPELLDVSADILETVVQLGNSRSKALLAALENLAQDPLKSLPPGIKTSALIRNISVLASQLESVASPRERNQVFCLQAAKAITEKLDKIIDNFATSNSLETPDITINTDVSPMSILTPKVASSSGGYEEIDAINLEDYENFDLLSWAINVDLGTSASDWTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9H3</accession>
    <name>A0A1Q5T9H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9H3"/>
    <dbReference type="OrthoDB" id="4352137at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="119" mass="13386" checksum="4A1AFE5CEDFE8B57" modified="2017-04-12" version="1">MAPSTPKKISKTKTNPKKLIFDQATLDQKMYFLWLHLQLKQGGKLNHMAVAEKLNINYKTAFGRFGQIKKYMEQYEESLAAPTPAADKATDGEDDSDNGGLKKAFDDLDNIFSKGESLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB87</accession>
    <name>A0A1Q5TB87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB87"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="406" mass="44046" checksum="27B68542AB78465E" modified="2017-04-12" version="1">MTPSNTPLRLSVTTAHDDKSISLQTPTSGSTLTPPVTPIAKELSDAERSIPSPVEEKALEQTTVQVKRNISTPLRFTDEVEICRDDEDRPVEFGRGAWSIVYKARSTLNNTTTPLHTPPSSPVTVSRVVAVKAPLRRDARKVLQAEALTLTRLNLTPGFEKHVVPFQGFLSDSDALVMSAVPLALSTYIEDHADLRKKQHSTATTFDPVQGPESWRDMARKLITGLAWLHDTAGIIHGDIKPHNVLLRRISTDEPGVDAGAFPYEPLLADFSSAFNIPTDTTLTTPDTNQASMSAFTPPFTAPELLSLASLKSGDVAPTPSSDVFSLAATLIAAATGDLLLYPGSNNMQRLAMAREGHRILEFTRAGSNGCRVPRNGFVEKLVQPAVSKDPAQRILTRDWMALASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB94</accession>
    <name>A0A1Q5TB94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB94"/>
    <dbReference type="OrthoDB" id="4364664at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="196" mass="22469" checksum="00C6F3A9D74673D2" modified="2017-04-12" version="1">MIRIVPELRSTLRSHGLPDTLRKSAHLITQLADPRDPDQIRSAPQKLVRVHLDDYCYLPAQLDAARDALRGMLRRLGHADVHVDIIFGSNVANVDITDDQSFDVQKVQLGIRLADAKVTEVLERFLPGKQVDLLPYITRQYGLDVPAVVVAVGPLCRTNWLRLRRLILAEVRRYTKMFLEVEFHPVYQEDQVKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBW5</accession>
    <name>A0A1Q5TBW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013044396" evidence="2">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="251" mass="27580" checksum="9681F45ADF619E75" modified="2017-04-12" version="1">MHHITTTLLAILLPLFTGLVHANVEKTIFLGPPATTIPSAAPDLDDLGLERVSPQNAVVRTQLNASFPTAEAPDGSDSWFFLENLTPGQRYEVRICWLATQPTTFTLTTHPLPDTVTSPILLTSLSKFSSSRLSNPDTQLQINPNTLTRRSNVDSAPTTDSILFLRIRAAADYFSLNETLMRDVPPVAVDVILDPFLWNVFPRSLVPTAGWIVVVAVLAGVVGRWVVAEVGRVIEDARVERSEEEEGKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBW7</accession>
    <name>A0A1Q5TBW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000687">
        <property type="protein sequence ID" value="OKO97717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="10745" checksum="D36CD098BE78880E" modified="2017-04-12" version="1">MGAIRKSSMYSSRRPDFRKQLQRALSLSSFESDETHSASEISIGNTTEDQHSMVSKSAESSVHSDSASHTYENQIGPELPSVAQMAEIVELPERPYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC54</accession>
    <name>A0A1Q5TC54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC54"/>
    <dbReference type="OrthoDB" id="5381833at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF2">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="157"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="255" mass="29353" checksum="EC4E7202CA7AE2AC" modified="2017-04-12" version="1">MPRNPSPRKVRHRRKVVHRRKGGVRKSKARSLIKDGKQGPDGDEAPRKAKRKSMPRMPESEDPLEDNVYERALMPKGYTFVPKGDVYITRKCRLMTKDSDQVVYKVYDKTGKRSLGIRVPSDIYNEVEAMSKETEKSRASATKARDTKFLDHGRELLREQFPLMPEDTLDVILEHAFQKGSGRVGRTGTLTDSHKAQLAVEAHVRHRYTLYETMLENGMNRFLARKKVWDTVQTIRQAWEGTGSKKDECLTLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDK1</accession>
    <name>A0A1Q5TDK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxyphenylpyruvate dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_9405</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.27" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO98307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="220" mass="24596" checksum="F723A6E0AC713394" modified="2017-04-12" version="1">MAPSAISTTPPPSTNGEVSSIASYRGYDHVHWYVGNAKQAASYYITRMGFKRIAYRGLETGSRHMCSHVIRNGDITFILTSPLRSLDQIDRFSPEEQVQLREIHSHLEQHGDAVKDVSFEVDDVDAVYYAAVKNGAKSVSKPRTLEDEGGRVKVATIQTYGQTTHTLIERGQYHGAFLPGYRLEAGTEDPVAKFLPGVHLKRIDHCVGNQDWDEMDKICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDT8</accession>
    <name>A0A1Q5TDT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDT8"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058535">
        <property type="entry name" value="MafB19-deam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF179">
        <property type="entry name" value="TRNA(ADENINE(34)) DEAMINASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="164" mass="17694" checksum="DC55226EFD9CFCF1" modified="2017-04-12" version="1">MITPTDKTFLNRCIQLAREALEAGDDPFGSILVDANGTILQEHRNRIHTESNVSLHPEFTLAIWAEKKLSPADRASATVYTSGEHCPMCAAAHAYAGLGRIVYASSSEQLKGWMGELGVSEGPVAGLGIKDVAPGVSVDGPVEELGEVVFELHRLRQEKIRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDW1</accession>
    <name>A0A1Q5TDW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9502</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDW1"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF75">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="271"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="508"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="649" mass="70418" checksum="E621E9B8E0BB32DC" modified="2017-04-12" version="1">MQPSEMFVGSIDQGTTSTRFLIFNRDGEPVASHQVEFNQIYPHPGWHEHDPLELVSSVETCITGAVRSFESQGFTRTSIACVGITNQRETTVVWDHETGEPLHNAVVWTDTRSQAIVSELKTRPGASNLQSLCGLPLSTYSSATKLLWMLGHVPKVKDAFERGTLAFGTVDAWLVYRLNGGAAANVFVSDSTNASRTMFVNLETLRYDDTLLDFFGIKGKIHLPRIVPSSDPSAYGVIVNGVLAQVPIMGCLGDQSSALVGQKGFSPGMAKNTYGTGCFLLYNVGEKPVFSTHGLLATVAYDFGGKPVYALEGSIAVAGSGVKFLQNNLSFFQDSKEVNDLALTVEDNGGCVFVTAFSGLFAPYWIDDAKGTIFGITQYTQKGHIARATLEATCFQTKAILDAMEKDSGKALSELAVDGGMSNSDLAMQTQADLISIPVYRPKMRETTALGAAIAAGLAVGMWRNFAELRDINRAGGAVFEPQITRQESATKFEQWEKAVCMSRGWISTDSTEGKDGDRTLNNETKPATHDSQHTNTNKTTTNGAPLPPTANRGLNIPKSAPRQTNSPLVSELITSDGFGTTLKVKTRSAANGESDRNRDWDFSPAKTPLISVSGDLDDADEEDLFLELRKVEILQKLKKLQKLKLGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE05</accession>
    <name>A0A1Q5TE05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kanamycin B dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE05"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="33155" checksum="548036BEB7A85089" modified="2017-04-12" version="1">MTQPTLTIIKLTPEELSTRKLNSHNLQAALQALHQDGILALENAVNTSHLDKLNERMIPEAKRLYANTNTHRNFGPDTGNIQQEPVVEKDFIFEDILANPWATSIIEHMIGPTPQLRFYSANTAFKATGRQPPHVDVEFKMPRMPFGYCININLVSTSPENGATEFWLGSHTDTDETVFDRQANNEPIKSELLEQRRKISPPIQPGLPKGSLIIRDLRLWHAGMPNRTDEPRVMLVSIQFPSWYRSDQTLVLPRVLEGKIDFGRTVPYVKWVGEDYDYLQGAHDHDLTLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE35</accession>
    <name>A0A1Q5TE35_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE35"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="18841" checksum="7CEE838EE67E2A6D" modified="2017-04-12" version="1">MDVSSNRLFRFSKPEWLNNSAVRNAGVYTSGALFAAGFFFLIDVASFSHSSLNGSDVHIKFVDWIPGICSALGMLVINSIEKSRLQADSFSYSGGGVAWKARFVLFLGFALLAGGLAGSVTVMVLKYLVKDYPIQTLYFGIANVVANGLIMLSSIVLWVSQNIEDDYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEK4</accession>
    <name>A0A1Q5TEK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="8901" checksum="6D069DC137D4488E" modified="2017-04-12" version="1">MPSSSNSSARTGSIQSHDSPKNVLQSKADPNAALYEAQPNMIEHVLDVVVASDSSESPGFIVAAPHDHVPKAEETPMWRTNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF90</accession>
    <name>A0A1Q5TF90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF90"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF90"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="538"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="852" mass="93364" checksum="77516E28B20A5D51" modified="2017-04-12" version="1">MASTELQKQVGQLFAVGFHGQTPSPEIKTLIHDYHVGGIVLFSRNFQTASQLRALTLALQNEARSAGHTRPLFIGIDQENGLVTRITPPIAPQIPGPMALGATHDPELAYEAGKATGEILNFFGVNMNYAPVCDINSEPLNPVIGVRSPGDDPEVVGRFASATARGLREQKIVPSVKHFPGHGDTAVDSHYGLPVIPKTRDQLERCELIPFRRAVAEQVETVMTAHISLPSIDDKYPATLSPKALGILRNDMGYDGMIITDCLEMDGIRSTFGTEEGSVLALQAGSDSIMICHTFEVQVGSIKKVCDAIQSGAIESSRLADACRRVAHVKDKFLNWEDALREQKLDELDALNKKISPICEEAYDKSVTLVRDGASILPLSKTANIVLLFPGGKTPAGGAVDGEGIGRQGSYEATAYLDALRRYNPSITEIKYGEAGLRDDQWSVVKAAEAVIFVSVNARESPYQESLGKLLPKNAQSLVAIAACNPYDFLQAPEVQTYLATYEPTVEAFSVAADIVFGAKTARGSLPVGLPDPKKSDMHVAQFDAEKDIDSIESVWKEALPTYILPADALRSLIDRKNAHHFVARIGSELVGFCLAYTNAHGGPKPVHLAVLAVTPKYQGQGVGTALLTETRSYFRTQFDINQLKLGSSFPRFWPGIPRELPETVQEFFVHRGFRLSPPGARSVDLYQDIRNFQAPEKYITRANERGFRFAPLRPEDYEACLVGQRRNFSDKTGWVEAYVTLDPKDYPDCVMTAFDSEGQQVGWTLMLPPVPALNKVWAFPQMCGPNTGLIGCVGIDTSHRKSGIGLAMICHAIDNMKQRGIEGVFVDWVALDGWYEQVGFKTWRSYRPGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFE8</accession>
    <name>A0A1Q5TFE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_8832</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFE8"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="15">
        <location>
            <begin position="128"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="15">
        <location>
            <begin position="244"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO98915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="38282" checksum="B1417BE44FCD23C9" modified="2017-04-12" version="1">MATMSPLQKEAATVPFRKNLAAHVICSECKEVPPNLEFDSHQTTCGSCGLVLGDRGIDMGSEWRTFSNDDQNSDDPSRVGDANNPLLNGDQLETTIASGATGRSRDLYRAQNKQSNDKQNKALMQAYKEIGAMCEGFNIQKNVADTAKYLFKTVDDAKAFKGKSQDVLIAGCIFIACRKCKVPRSFSEIFAVTKVSRKEIGRIYKSLEKFFTQNDEARKAAVVASGGTPDNVVYETTTSTKPSDMCNRFCNLLRLEYPLPRISVQLSDRVTASGILAGRSPLSIVAACIYMASHLMGQGKSPKEISQIVHVSDGTIRGAYKHLYAARERLIDPSWIEKDKGDMSKLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFU3</accession>
    <name>A0A1Q5TFU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Low affinity vacuolar monovalent cation/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFU3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFU3"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="539"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="931"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123808" checksum="9A8B7FB5EC54D65C" modified="2017-04-12" version="1">MAGDKRDPDQPEPSRVSGTPGSDYVSASSMPPMRSTASVRRGYGTLDAQSFDSASEVRNEETTQEDYSSRAFTSSSMVPDRPRKPSVTRRMSSKRQVPHKGQEFSTDDDVKEVEEDFALHKVSSNQQLSPRIRPMRAPGSTLRRHASARVSPLVRGESDNLSVDDTILPKPNLDLEDDAPSIRQSDGGSDNESEDESPVSDEDDEVTSDAESFTLKDRQQAINETHPFGIRIWKPALYKKSRSVEKTAEGDIHSSPGGRVSPMLFLTNLLWSALFGWWLALAALLAAIACFFCAFSSSAVAYGRVFAGLSRYLLYPFGSFVLLRTDDNYAEEDEGEGRSISEYEQWQNGDLEHGRLFFGPRRDRSLVGRRRNSIDSAGEQDSLLGRTQRGSGEDLQLNPSKRRLFGRGEWTLGRVVFFVFFYFWVGPLMLMVSLICWLLVFWIPMGRVTTILVSHLRRHPLALSFHSDTSYSRLATGSSSSSILLCTYRAAGTRYWKYTIDGTNIFFINLLALVAFVIFDYFVLDTFLGIESWLTHPGLIFTLSLFSIIPLAYFIGQAVASISAQSSMGLGAAINAFFSTIVEVYLYCVALTEGKSQLVEGSIIGSIFAGILFLPGLSMCFGAIKRKTQRFNVKSAGVTSTMLLFAVIAAFGPTLFYQVYGSHELNCHACVREYDPESRDCRRCYFSQSADVHDAFFEKAVQPYAWFCAVFLFLSYIIGLWFTLRTHAALIWATENEEKEKKAAQPISDSFTFESRHLLFPPGAPEASGAIPGHKDSIRESQLYKRILGQSLRQVGLEDTSGANWDQIESSSPLDKKVNIPHLVPPRSGGDDVPKGIRGLSGEENERLVRQVTEVAATAAAVAARDAARSRKYSNQQGSSSTRQAARPPAEQAKPHPPPGEETEDIGIVAEPAHNGGGHDAPNWSKAKSSIILLGATVLYAIIAEILVNTVDVVLESVDIDEKFLGITLFALVPNTTEFLNAISFAMNGNIALSMEIGSAYALQVCLLQVPAVVLFSAFYTRSIDAAELASHSFNLIFPQWDMITVILCVFLLSYVYGEGKSNYFKGSVLVLTYLVVVIGFYLSGYSNMDTLGVDRFDTLALGASRSEKFYTVGRSRSGAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGC8</accession>
    <name>A0A1Q5TGC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="252" mass="28268" checksum="974BB213AC158E29" modified="2017-04-12" version="1">MTVELERHNVHTIISAIGLVSNETSQSQLNLIEAAEKSKSTKRFIPSEYSFIQTPELLSVDPSIQWWLDAADRLKSSSLKYTRVIPGFFMDYWGMPHAKTNLHPYIFGIDIAGGVAAIPGDGNDVICMTYTYDLANYMVKMLELEEWPEFSVFVGDEVTYNEILAMVEGIRGNKFQTTYDSVEQINAGSVTVPPMPSTIGSPEELKAITALVSQLTVTGVFDLPRESRMSDRFPEVQPVKLKQFLEKCWVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGX9</accession>
    <name>A0A1Q5TGX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000657">
        <property type="protein sequence ID" value="OKO99459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGX9"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="158"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="575" mass="65656" checksum="0DD3853684922B2E" modified="2017-04-12" version="1">MGIPYLTKHLLPYADSVLLGGGPDDQNLDQTPCVRAVVIDGPSLVYHVYYRLLAWMGPVHDVLDMQPTCNEVSRAVVTCLVELSRRGIEIHKICFDGALPVSKRETRRARIEKSRHRLELSRRRAPTSTNEWREEVTIPPTQLWQGRNLPARWRNLPENPFMVSAVFEDLRTRWSREQILQETQCDPSHLPDGDYPWVEITVMVPGEADVECAHVSRLTGSAILTNDSDLIVHDLGPHGEVVYLNSVQLVEDTEDKASSQIRAMRLHPKELAHRLGIKDIPRLAYELNENPHLGFSELVRRSKENQGVIDHSDKYHDFLREYQPDTERSFAVRGSAYVQNLDPRVSELFWQYELPEVFCEADEPHIYLGILFEDHSRRCAWEVGRFYRALGYSLLNQAHSPARQFTTICEFVRRGTRIIAEQITLGGSKTVASDLSMLQKRLDLARGVFKAADPSTFWVMFAIAEIYRDPSSQTSLPGAVQLERYLTRGFVGKGTEWTDVHLLAQIHAVLYSLRVLQQLVRFLPDDNLSGSNRLMLSNLPPLHSLLLSRQEIIQRFSSSGELAHGLVYQLFKTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGZ2</accession>
    <name>A0A1Q5TGZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000657">
        <property type="protein sequence ID" value="OKO99455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="297"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="441"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="934"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="942"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO99455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1052" mass="115219" checksum="40B84B2B3B5A0C15" modified="2017-04-12" version="1">MLITPRTYSASQTPDQAPAASRFEGAPRFYTLAGWRQSLVEENPTADMLLVHQTGSVRVGEIIRYTPASDPILPIPSELHVRVKNTSAIPLRAAYLHGPYTLYAACYPSTFDPNAKYEEQDTEGIPQFEPYLKAGGSWDATIKMPARFGDGHNLAVGHLGSESDRTVTWVIEIVSQVIFSSSAAVHFELLVARDAKSIDYFSAGGTAAAGHEPPGKLQDHWPMGGTRGQPVIATSGVYSKSTTLRVDDTSSLWNSPPLPSGTSEASEVAPERTDCNSQHPSPEEATSSTTKAKPRKKKKVHLVVITHGLHSNLGADMLYLKESIDAAAAAKKKARTEERNKSEDSTENDDDDDDEEVIVRGFSGNAVRTERGIQYLGKRLAKYVLLMTYPDQPYYPLKTGKAKSFPRPFSARKDHAQPSLQPHSTPANHEDVIDGDDHAYKITSISFIGHSLGGLIQTYAIAYIQKHSPEFFERIQPVNFIALASPFLGLSNENPLYVRFALDLGLVGRTGQDLGLSWTSPKVRSGWSAIIGGRGDSAKDQTQTDPGSKPLLRILPCGPAHEVLKKFHHRTVYSNVVNDGIVPLRTSCLLFLDWRGLDRVEKARRDNGIVGTMAEWGWAELTGANSKSPRLVRPDEIPRLGEGQDGPSHGATDEAQPLQEDEELARPEDASSPDRGQFLARRKSSLHASSVGTESVHKDVSENNSGPFSSLLAFFRPKEPKPHHPSGKHAKIYKRSQTLASFDPNESPAPVVRGNSLYEEDIGVNTPPKTTFFESAGDVLMPPLPPADFILDPAARPRTIFHDRIYHPEDIPAPLPVKRRTLTFASLQPKNAKTAPPQATQIPSSSTPNAKGSESGLKVEEKIARAYHRDLTWRKVLVRLEPDAHNNIIVRRMFTNAYGWPVVKHLCDTHFGHSPNVEVDDTLKCNAERAKALNVGPTSSGDEVEGQSDTTEGESTEHEGTGPGHTHGGAVSPSGSGDYPQLHDLADALPAEHESHEAESTHTRSYSHYTDVSRQDSARWTDRQIDEDDDRESGLDVDGHAEFRWSPAPPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THV0</accession>
    <name>A0A1Q5THV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THV0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THV0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="290"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="382" mass="41533" checksum="7FFA281C96B1D4AE" modified="2017-04-12" version="1">MASRPTVSIATAEGKPSGASQPLPTVFGAPIRPDIVQYVEKRKTRTWQVHTGMAKNKRQPYAVSEKAGEQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNQCRSGRMFAPTKVWRKWHQKLNLNQKRFATASALAASSVPALLFARGHRVAKVPEVPLVVESKTFQGAALTKTKAAIALLQALGAGDDLVKVQKSRKLRAGKGKLRNRRFRQRRGPLVVYNPEVDGKELVRAFRNVPGVETSSVFSLNLLQLAPGGHLGRFIVWTSSAFEALDQVYGTTTTPSALKKDFLLPSAMVANADLTRLINSSEIQAVVRAPKGEARTKRVNVQKKNPLRNKQVMLRLNPYAAAYSKQKLGQQKVEGGKPERASAGFAKVLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THZ7</accession>
    <name>A0A1Q5THZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THZ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THZ7"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO99842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="26657" checksum="2F23004DFA2B3CB8" modified="2017-04-12" version="1">MAERILLNEFRTLSREEWVNIELHEENIFKWDVALIVLNKDSMYYGGYFKARMTFPQNYPYSPPEFRFLQPLWHPNIYKDGRLCISILHPPGEDEMSGELAAERWTPAQRVESVLISILSLLDDAECSSPANVDAGVMFRTDPDHFRSIVKAQVESSKANMPPGFVMPVTAAVTPPEVDKEEPDFWADSDVDSDVFGGSDSDEDLDMDQFSGSEDEDEDEEDDDDDELQAMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI51</accession>
    <name>A0A1Q5TI51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI51"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067139" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="225"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO99896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="886" mass="97209" checksum="E187EE57E1D9F7B9" modified="2017-04-12" version="1">MVTARRSWPTWLRYASVILALSAPICGNGVQNSTQPIDRASGLETCPAKTVWEVEAEIFQDQICLESRWGRGREQQQQQQPASTQASGVGGYSTSTTASTAVAVGGTPAVVAGQATDHEADEDSLLDGSSFLSFEDWKKQNLAKVGQSAENVGGSRRAAAVGKEGRRQPGINNALDSLGDDGEIELDFGGFGAETPEASPTAWGTPIPSQYVDPLDSDEGGGAHTQSPPKADVSRRKDAGTTCKERFNYASFDCAATVLKTNRECKGSSAVLVENKDSYMLNECRADNKFLILELCDDILVDTVVLANYEFFSSIFHTFRVSVSDRYPAKPDQWKELGVFEARNTREVQAFAVENSLIWARYLRIEFLTHYGHEFYCPVSLIRVHGTTMMEEYKHDESVNRAELEEEEEVVEAVETAEVSDKAEAQFVEPSIEEVTIEREKDSQIYEICPNPLTEVESLLLGRSVLSSETCRLGEETATENRPEKTTPSANTRQPPNINSTATPGNGASASQSGAVPPPKAPEDTRKPGDSTKPVASSPDAPAAVTDTSQQDSTVESTGKTTGNPKEEQQNSPPPESTRPTSTQPPSSNPTTQESFFKSVHKRLQMLESNSTLSLLYIEEQSRILRDAFNKVEKRQLAKTSTFLENLNITVLHELKEFREQYDYVWKSVAFEFEHQRMRYHQEVHSLSAQLGVLADELVFQKRVTMIQSIMVLCCFAVVLFSRGSVGTYMEFPRVQRMVARSYSLRSSSPPFESPSASPGSTRPTSSYQEHSAHRRNLSDSSSSQGSPNSPEVTYVPPTPTSDVSREFEEVEKSPQSPSPSPELMSVPTLGTPQFRSHSTPPVLNARSSELDLGGEGDDPILPSAASSVSEDPSQSQILQSRTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJG8</accession>
    <name>A0A1Q5TJG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJG8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJG8"/>
    <dbReference type="OrthoDB" id="4368470at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="275" mass="30956" checksum="D2C99F0AEB809731" modified="2017-04-12" version="1">MPAISLTPSSVSSRTVVSADQFKIQPQFEEAIFQTLREVQGFHELVVTDLPQGWEGFLWEVEESLPLIRKTHDPTSRTLRLKIMPTYTHNCVAEWISSSISRASATGFLNLAELDLLLLQSGTLLSFVNGSYRGLRKEPDALIHTPSQPFPTLVAEVGWAESYEDLLDDMNKLLVGGNGAIKIVLLVKWTRHSNNSVTGVLELYRNDRQGIPQLRQTEVIFPQPAGNPPQPLDIQRCDLYPARPPRNPNEHFPLLVNRLRYHAQISLTRQGYVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJR2</accession>
    <name>A0A1Q5TJR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TJR2"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1403"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1460" mass="158416" checksum="282CA679D86BF1AA" modified="2017-04-12" version="1">MARAAVLPPSPAKRGTRTAPRSTLTKTTASSQAKVVTEPKRKGVTKTTTARKNTLANVDIDSDDTEDELGMMMKEQDQKPARPRGRPSARSATKASTAAASSASTTTTRGRNVTPVAVLPESPAESDGDDNEASKKEPVKKRAGRPRKNAVPETTTAAKTETTPKPRGRPKGSTTTKTTSTTRKNTRTVPESEAVAENALTRHIRIATNSTTMRSNILRGRAKKKTVTFQEPSDSESDELKGPSAAAAAAAGNKKVEAAATNKAGLGATPMRKTTGAAVRGRKSAAVKKGAAKPLSPKKDKQVAKSLSAYASSDGEEDELSSAKYDITSPVKLVIHPPVKEGTEATGLSSPVRRINLTPKKASSLVDENGELKPATPKNGSSTTGLSSPVRKINFTPNRSVNAVADNGHLALPPGKSVDFSESVFMSSPARRPEASPFHFSLRDTPNRGLLFREDAKSVAEPDLGQGPASPLKMSPKKANLGASFSLSPSKASTPFSAKTSLIQSPPKRIPSPFKGSLFPSKSSVNAVPTLDDDPTIDLPVSESKQNLLPTEGFGHEDLTVDQDIEMVEEVARDIFGIELQCYGRSSSVSFSPQECSAAEEPLELEPADDTFDEPETVESCAEDIDIDEKLQELQEEIRREPEDFGTICFNTMEELQKPFQNLPEVQNVEHNLILNDLDDTMETDVEEEDIPESSAVPEVHSEEVAQMDTPDGEPEQQLSSPSDPTLGLADREDAQSPTPVPQILEEYIDLARHAREDLEANEAEEAGTESDHSEYNEPALTQDEYTVQVLSLLGTPQRVREAEAIESPLQSTQSIPPVALTPPTREMSIVSPNEQDSAKSKDWIFDINTDARMPVENSFLDTTQTEIPSPTGHAICDTPNFAGKRQSLVNVDSGFTPLARKFDSWETNTPSQAKPNRTRRRGVFSLVGPLEKPGEHATPVQDDVSYPDLSRTPLADTPSLSAELPLQAKNDVVSTPPQSPHTPKSAVPQQEPSEMYSPIRLDIFEDPEFSDFEVMVPEQLQPAEGRRAPESTEAQDEGPLSDDDDKENCHSPVIVPTTPIRRGIDHLRTVHTVSKVPLKGEGEVSPLKLPRKRGHSLESRSPTRASPRMRKPVRFHGSEIVPTFSPHKAPRASRSPSPKRRCSTPRGSIGAQPDVRVPQSPSVASSAGKTPRRKSMTSQQALRGAVVYVDVHTTEGEDASGIFVELLQQMGARCFRSWSWNPRSSMSPVDGVDPKESKVGITHVVYKDGGLRTLEKVKHAGGLVKCVGVGWVLDCERENKWLDETPYMVDSSIIPRGGAKRRKSMEPRALSNVNGTLVRVPEPSTPSASGRRCGADRGAVEGFRKITPPTPLAGIPTTPVQKSERYHIPATPGYNFDNLDAIGMSPATPYFLSNRAKLVQKSCPPKQSNRGLFEGTDRPIFSLEQDDEVESRRQQRARMEAARRKSHFYKPSAESPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKQ8</accession>
    <name>A0A1Q5TKQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_7733</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKQ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKQ8"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="92"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="291"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="499"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP00802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="695" mass="76046" checksum="1F823520506F0C62" modified="2017-04-12" version="1">MMPLRPSKTALRALHLQRQLASGRRPFSTSFVASAASTHRSSPQKRAQSTATATSNSRPVPSPAFNQEPHRNEISPLQNRQLPELDESMVGMSGGEIFHEMMLRLDVKQIFGYPGGAILPVFDAIYNSKHFDFVLPKHEQGAGHMAQGYARASGKPGVVLVTSGPGATNVVTPMQDALSDGTPMVVFCGQVPTSAIGTDSFQEADVIGISRACTKWNVMVKSVGELPRRIQEAFEIATSGRPGPVLVDLPKDVTAGILRNPIPMHSTIPSLPSAATVAARELRQKQLESTISRVARLVNMAEKPILYVGQGLLARPDGPEILKEFAEKANIPVTTTLQGLGGFDELDPKALHMLGMHGSAYANMAMQEADLIIAVGARFDDRVTGSIPKFAPQAKAAAAEGRGGIVHFEIMPKNINKVVQATEAVEGDCADNLRLLLPHVKAVPERPEWFAQINDWKARFPLSLYERQTEEGTIKPQAVIEKLSDLTAHMKDKTIITTGVGQHQMWAAQHFRWRHPRTMITSGGLGTMGYGLPSAIGAKVARPDCLVVDIDGDASFNMTLTELSTAAQFNIGVKVLLLNNEEQGMVTQWQNLFYEDRYSHTHQQNPDFVLLARSMRVAAERVSKTSDLEAKLKWLIEQPGPALLEVITARKVPVLPMVPSGRGLHEFLVYDEAKEVERKAMMKKRNAPTEVNMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKQ9</accession>
    <name>A0A1Q5TKQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKQ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKQ9"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000002">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="4" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="6" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="11">
        <location>
            <begin position="42"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="9">
        <location>
            <begin position="142"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="10">
        <location>
            <begin position="407"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP00801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="523" mass="57434" checksum="107373ABE8457A5B" modified="2017-04-12" version="1">MSAPQELVPQTESIAEVYATDDASVNSVAPAHQQRWANLITQFNKEYNHRPDFVARSPGRVNIIGEHIDYSLYDVLPTAVSVDVIMAVKVVPAGPSGTTVKIANVTPEKFPAREFSVPHDTDIEIDPKKHEWVSYFKAGLLGALKFLRKENAGSLVPVSMEILVDGNVPPGGGISSSAAFVCASALAVMKANNHNVSKQDLLDLAVVSERAVGVYSGGMDQAASIFSKRGFLLYTQFFPKFRAQHVPIPKAADEITFLMAQSFVTSNKAETAPKHYNLRVAEVTLAAVILAKSFGVTLPKDNSSLGYSLRNFHEQLMTKEERLHDPLEYQIDSVIQAVQDVLTKEEGYTREEMAALLDTSVAELESKFLSSFPVQAERFLLRQRALHVYKEARRVLDFKACLAKASGLDDKRIRYLGQLLNESQESCRTAYDCSAPQVDEICDIARRAGTWGSRLTGAGWGGCTVHMLPQGKVEAVTTALRNEYYLKNFPDMSEEKLKQAMVISKPSNGSFVISGAAIDQVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRS4</accession>
    <name>A0A1Q5TRS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit 3-like middle region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRS4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRS4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="2">
        <location>
            <begin position="64"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP02910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="239" mass="26757" checksum="656326C9A0F91ED7" modified="2017-04-12" version="1">MPDDAPFLPPAEQEIAPLINDAKLARTALKEAKSELANGTFSTSAYRQVEESVKRNKEFAPAMQYQKLIQIPHTAASTPDQEQGSNGVKRTLGYLTPERETEYYLALDAKLGDETAIAQLARIPDPPTFAEREREAVLRNPASVYNWLRRNQPQALQEHEVASEKSTSRPSNARSSKRAPAQRKEEENLDEDGMEMEPTPKNKRKRDEDAGYRPKGGNNRSKKKKDEPAAANNRSAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT26</accession>
    <name>A0A1Q5TT26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT26"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT26"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012863735" description="Extracellular serine-rich protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="25443" checksum="3D1C451FD0E9B324" modified="2017-04-12" version="1">MIKASLCTFTLLCLPLAGAQYGGGGSSDTTTTTASSTESGSASSTTQSVDVGESGFTFNPDTIHVPAGGVVEFHFYPGDHSVAQAAFNNPCHPMSDTSFFSGFMASARDGKPVWSLTVNDTNPIWFYCGQVGHCQAGMVGVINPSGSDTLDSFKSAASSANGQSVPATAQGGILGTPSASQTTTNSGSKTTTSGGPAVTSSMTTSSRTSAASGTPTTSTGAPSPSSTNIAGNLRVSTDLSALSILTLTVAMFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU05</accession>
    <name>A0A1Q5TU05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000616">
        <property type="protein sequence ID" value="OKP03704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU05"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="9051" checksum="2E3DC575C2D77EEC" modified="2017-04-12" version="1">MVSQDWQALIDEKRAQREASIPSKWRIPGHVADKVSPTASVSAFELLEETDILSKEEREITERENLSCALDHFEGKIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUA6</accession>
    <name>A0A1Q5TUA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial GTP/GDP carrier protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_6820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUA6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUA6"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="221"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP03811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="33138" checksum="F5C3E6BC64D106B8" modified="2017-04-12" version="1">MSPAIAAGAGAASKDVKRESATARLLGSGCAGIAELMVFHPVDTTAKRLMSNQTRIGSAAEFNKVVFKEYADATVGRKFTSLFPGLGYAAGYKVLQRIYKYGGQPFARDYLAQHHGATFDNAFGKGTGKAIMHATAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRGRGLFKIISDEGMGLYRGAGWTAARNAPGSFALFGGSAFAKEYIYKLKDYNAASWSQNFVASICGASASLVVSAPLDVIKTRIQNRNFEHPESGFRIVSNMMKHEGFPSFFKGLTPKLLMTGPKLVFSFWLAQTLIPAFGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUA8</accession>
    <name>A0A1Q5TUA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthetase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TUA8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17653">
        <property type="entry name" value="A_NRPS_GliP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1511"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2004"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2038"/>
            <end position="2047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP03789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2210" mass="241998" checksum="24A1DB01119E53F1" modified="2017-04-12" version="1">MIAKPSSVLDLFLAQARQQPSGIAVSKAGVNLNYSALDRESDAVAELLQHRGVVSGDIVPVISSRCLELPVCVLAILKVGAAFVPIEAGTWSRARIDAVLARLDFKTVIATGDENYGVSMIQGVELGDAIRAARTTATPTQPRQRCLAPRSMAYIIFTSGTTSTPKGVCVAHETLLNCVAPGHEDAPINFGVRPGDTTLALFSIAFDNDAKNCTILPATPALLSAIADPSTYSNIRTLFIGGESSPPSLIKKWSAHNRQLWNGYGPTETTISLTMGELRPGRPITLGTPVRNSKLVLLNHNLEESDEGEIGVMGSAVLALGYYKDPQKTDEKFIHWRGNRLYLTGDLAKRTEDGLIFLGRKDQMVKNRGFLVNLEAEVVPAICSQPGVESAAAVMHLQRLVAFITPASLDGTTLRQNMRSEFDSFIVPDEVYSLDELPQTTNGKIDHRSLLQELSRKKLRPPPIQSTSTGILLALEEAVGQCLEIPSTFVDVNKSFTGLGGNSLLGIKLLSILRQKGLTASTIALFSLPSLVEVSKVLEVIEDADGVLDLVPNVGVSSLKPSHNESSKASFAMTDVQKGIIRSSLKEPLTGYMLVTISLHASQNDIDGDALSRAWELVLADYELFRSSFEPANESFTISTTYVHDWKTAFSTKATMPDDIARESELLLQAAKSNTRDGNIFTPVNAFRLILSPEKSSVLLWLIHHSLVDGWSVGEILSQVRRQMDNDRHEPPTKQFSTYSQSLSAFSKIAQGKAEKFWTNRLENVTEGTALNIWNPLGQASKAGAIADESISTGLSLAQLNVGAQSLEVSSAVVLHTAWAVLLSNYADKDEVVFGSVFSGRSFPREDVAEVVGPIINTCPFPVRVSESGSKYDALQSVKEVLLGIADHQWSASAMLQQLAPGTMSRLFQTALFLEYDLPMNSSVAGKPETKWDINKRGWPEFGLTLQVQQAAGEIILRVVYDPGDYQKDSMSPLLHHFRNICLALLDPNVLQLKTVKDMMLTSFTRLNLTRNSPLLYSPYSGSRSLKEKFEHGVRCWPDAVAIESSDESYTYSELNCISNYVARVISELAGPKQVVAVLADGSRYWLICALAVIKAGAIYLPLDTKLPSERMKSMIRTAGVVLCVYPNSKCHELRSSLPGAHLLAEKIIHNFNSLENRIEALESTTDIDDYAYVMFTSGSTGTPKGIKVTHRATLSHLSFEPARLHARPGRRLAQMFSPGFDVSIAEIFGTLCYGATLVLKDDADGLAHLSRVNATMATPSLLATLPPDKFRNLDTIYLIGEDVPQVLCDSWAGGRTLYNFYGPCECTIAATWTQIEPGKPVTIGKTVPRVGAYVLDRYKRPVPAGVIGEICISGVQVMEGYIGTDAEAITKRAFGPDPFDRNHRMYKTGDRGAWTSSMDLKFLGRVDHQVKVRGYRVELDEIENLIRNADASVSRVTAMVVQDAIYAFAVPETVKEGDLISKLCRQLPTYAVPQRIFALPSLPFTPNQKLDRKALGTMVTTAPKIQKKNQTLTPIESLIGQKWAESIGLETPTGLGPEDDFLAIGGNSLRQITVARQVCAHLGQNIPLSLFIHNTKMRTLAKAIETHTAGQQRNGGVGFDLFTPTAHNGVSYLEEMRYHKHNSSTTPSALNVAFVVTFSGDVKTNLLMQAIKKVMSASDIFRTCFARQGASLRRKILPKTPEVMHEELHSGRIVSALVDLPFNLETGPLTRIAMMGSGQVVQVVFVQHHIITDQTSVALFFRQVGEIYSGLLSGTDVVMKPPRPYADWAQWKNRRLTEPPTTEDVNFWKSHLRNVSNLVHRCPQPPKTLQDAAHSTVARLKKPASAAALGLFLGVTAVAWSRVFSVDSAVIAIPWIDRAEPGTGDMYGIFLDALPVCIRSARTRNLGTIVTEASAAVKSVLSHALPSPQIRRIVQEESLFGVVLVYNRMQDQVSAGLDLQGVSVTSAAKRAAGAKYPVLIEFTEGEDFISLEIEYFKEALSAKALKQLEEELASLLEEISHPTPDAAANEKPGSYRFLSTSDKRSRPDYTGLDGSSTKKRRKRKDKTKGDHIGNDNMQNGKDAVVTQKGGTPVPYPPTSEKPAEIAPCLQLQALSNQPAIPINTQRIETVLNRVPDSILENVQLCAVERSAWKVRAKVCTDNCDNQVSPMRRHDIADPEHEFLDSQCSARALCGSGHVYAIRPNFGTWQEHENIINFKWTNTRMLAENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U074</accession>
    <name>A0A1Q5U074_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U074"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U074"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="325" mass="35920" checksum="8989E5465DEBDAA1" modified="2017-04-12" version="1">MQELIEEYDAVEASEMQKLQKLRVFMTDSKFEDFQESIARLEADHPSMKGIYTILDADTVLKEYGIHGASGGALLPAGTVWPYRLVTKVFDALLKKYPGRLTIETNTAVEAVEYDEKFLTPITSVFPYTLRTSRGPMRAASVIYCTNGYSGHLLPCLRGRIHPFKGTMTVQDPGTSIPNQGKFVSWGFHYPPTYEPDTQRHGYGLYYLGQSAKTGYFYFGGENTRIDEAVSADDSFVASHSVSHLQSVLPRFFGKEDKAPWKLVSSWSGIMGFSSDGLPLVGRLSPALTGRRGEGEWIAAAFNGYGMANCLMAGEALALMILGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U085</accession>
    <name>A0A1Q5U085_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_6614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U085"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U085"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011982008" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP05894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="460" mass="51006" checksum="86CF0C9C4D65D760" modified="2017-04-12" version="1">MRVAGHSTRPSWASLLTIGLAGIGTVNAVDMDIEDADSIKKAAKEIATNMMTYYTGMNPGDNPGNLPDPYYWWEAGAMFNVLIDYWFYTGDDTWNDITMQGMLWQAGDNAAFMPNNQSKTEGNDDQAFWGFAAMSAAERNFPNPPDGKPQWLEMAQAVFNTQAPRWDPSTCGGGLRWQIFTWNNGYNYKNTISTGGFFNLASRLAKYTGNQTYSDWAEKAWDWISDVGFMTNDYHFWDGASDLSDCQDMNEIEWTYNSGVFLLGAANMYNVTEDPKWKERVQKILDSGDLFFAKTPPNVMYERACETVNTCMVDQRSFKGYLARWMAATTQMAPFTHDQIMPKLKASAQAAAKTCTGGEQGTTCGLKWTDQAWDHTKDFGQQMAALEVVQANLINRVAPPVTSDNGGTSKGNPNAGGKTPQSKPEALTYKITTADRAGAGILTAMMMVTLAGSCSWLIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D7</accession>
    <name>A0A1Q5U0D7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0D7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0D7"/>
    <dbReference type="OrthoDB" id="5793281at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02234">
        <property type="entry name" value="cupin_BLR7677-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599:SF1">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="130" mass="14332" checksum="87FD510EC43CE48E" modified="2017-04-12" version="1">MEEPTYDASRPMPDINIIYQYKLANCPGKSIVGLRVEFPPKGSTPPHRHGGSSVSAYVFSGTLLNKMNNDPMKVIKAGETWFEAPGCHHRISDNASKTEPATLIATLVLDTDVLERDGMGALIQIDEEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1K7</accession>
    <name>A0A1Q5U1K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein bli-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1K7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1K7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="114" mass="12169" checksum="60A828D03B00803B" modified="2017-04-12" version="1">MSFLDPVSGAWASISGTASILSNPETVQKYYSPQLKAWLGDMGDGVHDGGPNDPRIGVIKLEAKLATHVAAKKGILGRATDTVKGAVKGEVPNINSIRELSMAELAEWRRTHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1M9</accession>
    <name>A0A1Q5U1M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_6380</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U1M9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057030">
        <property type="entry name" value="TPR_Rkr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23280">
        <property type="entry name" value="TPR_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="1451"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP06390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1503" mass="167016" checksum="598E6C5D75F5384E" modified="2017-04-12" version="1">MGSVAGVVGKRIAPYLPKVVGAWLAGLYDSDRPVHRSALDSLTTVFSTEAKRNSLWKICQSSILDFVDDVLLHQNPLTLSDERTVKRDDAEAKYARVVGAALLLFNRILGNSPDEDLRKNLPEIEALLANKSLWAFCTHDDPFVRRSIYVILRSAISREPAWVDWKVLSSAIIGKSLSSPQLGSASELSESVLLLTSSRPQIWTDDYTGKTSASKRLRQYIQKGSQGGHGNFWSNLDQILRIIPQGVLAGADKTSTDGVITISSASALTEAFQDGLTSREEPRQNLSIGWKTYVRIGGWLSTVVPQEQQLEFIRTRLFPLVVSYVRPDPEQPQWILPTQLAEEICTDCIATLVSNGQHEGLQALWRQLSNDLLEAVKLSSPEQSKDYRPSQDSICSQSKRLFALVPSILSRASGAENEATVQKIFEQSALLLLEGCLQVLHSRNGKPYGAAGVVEECVRNMPSVAKGSHELLQFIQNDAPGLLFSPSGDRLITIILACREWYGFSSSFESVVESAMELEPEQSNAHILQSLLSNLDFNEIGDKNKLSSLIMRALDKSLRGSHSHWSIIISALRNQTSQGQLRDQIFLSIIDALSQDDRVFDALHGLSHLGQAVPSIVREFQTGTHGSKLTAKLLYLTESPSEEVASLAESLMKSFKETVIGDTSNKSKIEILHSEFNHVNEESLSIESLFVIAEELLHGLAADESDYTVKDILPSSDAWENAMGPFLQLPPRVSTAITSPLGGIVHLVQRDISDSFKALWLAIPRDSNRCSAAFRLASFTIHILSSFKVIKNLTTDDLEILMYYLPIAVQLIDDDLSIEHCNGISGLTSATQREDYLETVFKGRQIISNWIHAKDLLTSSSTVTVSSALTSFWENKLESLSGNSPVDYRIGEAFTKLMTSIDVVEHPKSADEIAKICRESRTANAIRSASWFAVLRSSILSSPVGSRVCNELVADSTGLKPLDPGSDGLRKLALLNILLSGEENFVSTIATQRLVFLAKHLIECLHSDMKLPGLKAEILRTLTFILPGLAEIYGSHWEESMDILSVIFKETNGGEEGLPLLFSSFRFFARLKSLAEGNSNDDLQDAWSERKSGLFNEVASTIGNFDSATTFHQPRDVAVELLRRLIESIPIEKLEDVSGVFGLLTAHSRSVQRTAYTILHRFIPQAQEQVSFDMALSKASVSLPDELISLLLEAPSMQMVNEAYGDDKMWTTIRAYLLSWKVVFDHFTNASLPVQEFYTTNIKENEVLTPLLEFTFDFLQKSHGKIVDASKFDVQNFEPDQSENAEKETEWLLIHLYYLCLRHLANMTKNWWIDTKKRIKGPVESWTEKHISPLVSGDSLEGVTEWISTQDPNEERALSVKISPKTAEIIASIPVDEESPPVSISISLPPAYPLHPALVVGRSRVLVDEKKWKNWLLTIQGVIMFANGNLVDGLLAFRKNVQGALKGQSECAICYSVISTDMQTPNKRCATCKNTFHSVCLFRWFKSSNQSTCPLCRNNFVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4Q3</accession>
    <name>A0A1Q5U4Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4Q3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="150" mass="16564" checksum="87CA53DC6B76A88D" modified="2017-04-12" version="1">MASTRIDPDFDRYFQTMDWMDGDFIHEQSPPQHGAEPGRAYHSPTSTNHSHGPYIPEASECASQNAWHFPRGQNVSLQSYHGVNGGPSQHEPVPHNFDQRSSRAQATTGLLHQSSSGLPASHVAPANGEADREVSFSLSGQRTRRRYVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5Y4</accession>
    <name>A0A1Q5U5Y4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5Y4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="467" mass="51304" checksum="6D03A5E4DAAB066E" modified="2017-04-12" version="1">MPYWEKLFSTGYRGSDGNLTITSSQASAIVSILSAGTFFGALGAAPMGDFIGRRWGLISSTGVFTLGVIFQTAATVPLYQSETAPKWIRGFIVGSYQFAITVGLLLAAVVNNATHSRNNTGSYRIPIAVQFAWAIVLVVGMFLLPETPRYMIKRDNHQGAVRSLAKLRRLPEDDSALLVELAEIQANHEYEMSIGSAGYVECFKGNLGKRLLTGCFLQGLQQLTGINFIFYYGTQFFKNSGFKNEFVISLITSCVNVGSTIPGLYAIDKWGRRPVLLVGAIGMTVSQLLVAVLGTTTTSQDAFGNIIVHNEAAQKAAIAFICIYIFFFAASWGPIAWVVTGEIFPLKVRAKSLSMTTATNWLLNWALSFSTPYLVNYGPGNANLQSKIFFIWFGCCFLCIAFVYTMIYETKGLTLEEVDELYREVSSARKSVGWKPTITWAEKKEASDTFGEKGQLAEHAEFHDAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U770</accession>
    <name>A0A1Q5U770_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_5698</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U770"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U770"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="563"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="886"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115613" checksum="B8508B83DEE1440D" modified="2017-04-12" version="1">MAASWFALRGGRQLALRSRVRVGPSPVSLRTASVAPLNITRRALHTSQHATTSPIRRGVYTSSVNAHGDPHPEDIFQPLDTFPRRHIGPSPEAASEMLAVLDPPAASLDEFVKQVLPEDILSKKDLKVSEPHADINLYRSPIQGGLGETDMLKLLDTYRKQIDISGKTYIGTGYYPTIVPPVILRNVLENPAWYTSYTPYQPEISQGRLESLLNFQTLTADLTGLPFANASVLDEATAAAEAMTMSFATMPASKQKKAEKSYVVSHLCHPQTIAVMQSRAEGFGINLVVGDIMANDFQLVKDQGDHLIGVLGQYPDTEGGINDFQSLSDSIHTQGGTFSVATDLLALTVLKAPGEFGADIAFGSAQRLGVPMGFGGPHAAFFACADKYKRKVPGRVVGVSKDRLGNRALRLALQTREQHIRREKATSNICTAQALLANMTAMYAIYHGPVGLKSIAQRIMSMTSLLREKLVGLGYNIPSRSNVEGGAVFDTLAIELADASEADAVYAAALKANIFLRRLDGNKVGLSLDETVGRDEVKGILDVFAAYKGASPVEVDGTLGLASVPASLERTSEFMTHPVFNTHHSETEMLRYIRHLESKDLSLAHSMIPLGSCTMKLNATTEMIPISWPEFSQIHPFMPAAQAKGYIQMIDDLEAQLADITGMAEVTVQPNSGAQGEFAGLRVIKKYQEAQGDAKRNVCLIPVSAHGTNPASAAMAGMRVVTIKCDTKTGNLDLADLKAKCEKHKDDLAAFMITYPSTFGVFEPGAKEACRLVHEFGGQVYMDGANMNAQIGLCSPGEIGADVCHLNLHKTFCIPHGGGGPGVGPIGVAAHLAPFLPSHPTSEYLQTKRGSSSSPPISAAPWGSASILPITFNYINMMGDRGLTHATKITLLNANYILSRLKPHYPILYTNDHGRCAHEFILDVRGFKETCGIEAIDIAKRLQDYGFHAPTMSWPVANTLMIEPTESENKAELDRFCDALISIRAEIAEVEAGKQPREGNVLKNSPHTQRDLLSTEWSRPYTRETAAYPLPYLVEKKFWPTVTRVDDAFGDQNLFCTCGPVDDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U785</accession>
    <name>A0A1Q5U785_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-(Hydroxymethyl)glutathione dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U785"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U785"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF3">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="380" mass="40569" checksum="F3F7EA958D37B50A" modified="2017-04-12" version="1">MTAKKELVAVTWGGNPLQVNVSTLPIPQILDPTDAIIKVSLAAIGSADIHTYNGVYEDKEVPWVMGQEALGIIVEVGNSVTSFSIGDKVVVPDQTSNGLEDLSTAELMGLGLGSEYYLTTGCQAGYVRVPFANDNLYPIPQNDADSLKSSVTDLDLDYLLATGIFATGWGALDLSGFQPGDSVAIFGAGPIGLMAVYSAILRGASRVFLIDGDRQRLSIAEGLGAMPIDLTHSEPISKILRQEPDGVFRSVDCVGIEAATKLHRTEDKVLQNMTAITKDGGGIGRVGTFKTTSNSSSTSPWQFLLPNFQLAVSGLFKKDPQVRSGVIDSALIAPKLIEMISKGKARPSLIVSSIIDVNEAPQFYERASQHLETKVVIRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Y0</accession>
    <name>A0A1Q5U7Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7Y0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11284" checksum="BBE3B6E18626A363" modified="2017-04-12" version="1">MNITSLQATGLDQNFSPLMPSNPSTRPDEKAVEACRPIRNVDWREDPQPVENFHQRLVAHWQRCGEAAPQGKQYSPCKRGSGFSTAASSTTPVKRCSQEVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Y5</accession>
    <name>A0A1Q5U7Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome component ECM29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U7Y5"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1319"/>
            <end position="1480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1875" mass="206755" checksum="6A7348C60A0A4E92" modified="2017-04-12" version="1">MASDLPSPEARELSLIGKVEFRIAMADSDEKLQSLLMTYLAPILLKLSSDSVAVRNKVISVCQHVNARVKTPSIQLPVAALLKQFKEQKSQLVRHFDLIYAQQGIDRLGSEARVDILLPLLQGIAEIGTSASQGAIVFNLVLRLLPLFKIPPKGSDEDQKLKERLKLSDEDTGFLSFWLTKLLLLSPAVAEAQTCPGLSPDEYKFLNKDAPANETWNPAAPGGLNLTETKVIALRFLGSGAFADSQRFLPSLIATADANSRLADLGDETLKRFAVDLEDSTVVEQLYDLYFGSGKADGAPPVRPPLQVRILVFLGKSIKATENTQRIYRLIEDGLLSDAARSAQGLQASKLRTQIFTFTTWVVRMGSPSDLKQIAPKLIAGLRDFIQSQGWPSPGASGQRLPATDLSLRGLAYESIGIMVPKVDFQLRDETGENFEFDLVRWLFTSLSSDDSSPQIFVSIDQALGSILNSSLDSHDKEFQDQLRPFLVNQMGLHQGDTDPDNGFDVVRGVQYAAVRFANRFLPYSDVVARWVDLMAIARGPERQQEIVEEGKKGLHPYWFRLLNPAKDKKWEATTAVGERDESWFEFPKFAEATQYLFGSSDQDTTSAAQGISTPQILSGPYKNAFVPAVAFLRNALLSEAFSAAGITTELEQDWDYKLEVELSASVEARNAVRKYICNSAKEPVFTFLSGILHGIVKEGIPDLRQCGLNFVEICSLAPNDVVEKLLPLAQSLTKPVFSNNQDMQGYAARAFGILVSHPTFDDSTLKNSVTELVGTIESWNTAIGEAALRVRGAVLSLSYLLSRLAYRKLLDKVPEAQIKNIIDTVLDIIDASRDNLLQRTAELALGQLSLSGIISLQTLQEDGWKKLQKKLATDAKTENNTPISALGLLTLTFSRAQPDTSLFNDFMSSLYALHEIKSPEVQFTIGEALSNAAVGWDSRALIQEFDVDADLPQSDVPRTVFAEVCDKLIKDCGASKPSLRKASAIWLLSLVKNCGHLQEMQERLRKCQATFTSLLGSREEVVQETGAHGLSLVYEIGDQSLKDDLVRDLVDSFTATGSNLGGGNITGDTQLFEPGALPTGEGSSVNTYKDIMNLAAEAGDPTLVYRFMSMASNNALWTNRAAFGRFGISSIFSDSSVDGYLAKNPKIYPKLFRYRFDPNPNVQRSMNTIWQALVKDPTVVVDTHFDQIMEDLLKSMLSGREWRVRQASCAAVADLVSGRRPEKYAQYLDEIYGKAFKLLDDIKESVRVAALKLCQTITNSVIRTLETNGSEKRAGVLLGSAVPFLLSDKGLDSSVEEVRGYAIGALVQIIKKSPGTLLHPFVPSILEKFLSSLSALEPQAVNYVHLNADKYGLTGQEIDKMRLSSIRTSPMMEVIERYLIDHLDESNVKDLAPKLENTLRTAVGLPSKVGCSRVLVLLSMKTLLFRPYADRFIQLLSKYVVDRNETVSASYCTSMGYLLRLASDDQVLKTIDYAKTLYLNSEDANTRTIAAEILYSASKLSNDRFMAFATAALPFIFVCKHDADEHVKEEFDKTWQDNVGGNRAVSLYLREIVELVADNLDSARWAIKHTAARAIAQAVLSLEGEMDLPTAQLVWPVLEKALSGKTWEGKEVVLTALVKFARSGRVLWTSRTELAELLKTIAVREAKRTNAAYRPHGLRALGQISQAREVDLMPNALAIIGPVIDEVVDEQNDDGDKMEIDGKGPDSTETLAACVQCLLQCLNPATAETEVLGNYIRQVIDPLDQALTHGARQVVSTVYQELQAFFTRVDQWPGFTEAAAPESAPENKSQAELESESVLAGPMRGLTSLLLRERDAVEVVRKGRAEAIRSYLKLRPDLRGVCEAQVGECLRVWRAAERSSTVQRLLDEALNLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U816</accession>
    <name>A0A1Q5U816_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U816"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U816"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32361" checksum="D52635731330C702" modified="2017-04-12" version="1">MLTAYRSPVRHLTYWHRRHTSKERLPVLFIHGIGIGLYPYTTFLRDLDRELETGATADNEVGIIALEVMPISSRITHPALEKDVMIMEIMGILQYHGWCKFVLVSHSYGSIIAAHLLKSDQIAALIGPTVFIDPVSFLLHLPDVAYNFIARRPARANEYQLWYFGTKDLGVAHTLAKRFSWTDNIIWKEDLGIKGGKNQEGRNVTVVLSGKDLIVDAEAVGLYLMGSSSEAQTGEEEATRAWKNRSWIGYGLELLWYEQLDHAQVFDVENTRRPVIRVVSSYSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAM9</accession>
    <name>A0A1Q5UAM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000504">
        <property type="protein sequence ID" value="OKP09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAM9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAM9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="470" mass="52150" checksum="67CD70E612B6D5CE" modified="2017-04-12" version="1">MGRNAIWYAVASCDEQLVQILLERQSDIWMMDYRQTTPLSLAISKRNLPIIQLLLDHSQARPSQPRLVDVNAGDHPLCLAVYAGLNEIAQTLIEYGAELHVRDRYGQPLLHRAASNGHDDVTKLLLGHGVDVNSTDPGGRTALHFAAFYGHKSTTRLLLSTPGIDIAACDSEGATPLCAAARGNHRSVALQILAEEPTNINARGFGQKTALHFAVQNRNFHLACLLVDLDSLDPNLCDDQGWTALSYAACQGDIRMLELLLTRTDLDLDVPRASPIYLAAERGHVEVARRLVSLQQVDINQTFCHKSPLFIAIENGYRDVAKVLLAQGSRLDVNAKTSLGDTALHMAVSYGNLDIVELLLKDDRLDVTGTNRYGESALELAARNGKEHVVRRLCRDHRVRIVCHFRSAMEATSNLRIMYFLQGQLMRHGVEHGVRRSARLAGGSYQIIESRTRPSLRRSARLSQSRVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB88</accession>
    <name>A0A1Q5UB88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000469">
        <property type="protein sequence ID" value="OKP09733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB88"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="41272" checksum="8B6455CB08116406" modified="2017-04-12" version="1">MPNSDTDTSEDDRLMAQVNEKDATTERPDPDRPSFQPFLGDHDDHLSIVVPDQPGDRENRRALGFIQYEKEAGRITIANPCMYLPINALAMGFSTKAAHKHRVEHHGEGLKLAASSSLEIATSLGKRPARLPDTLWQMLRAHGPIGTVEEEQQKRFKDAKPCILPDTTFARAVDRALRACFALLKFTDHIQVVYIRGSTGKVDVYFDKGQELLVRSLASMFKAHPTSRPAELRFMRQIGRRLRYLPHSIQLKPYSGGILVSWEDNEAESVRRLGPSGPDYHIVLHDDKCANAEMALLLHHAALPNDVVPCGCRRQFARQAHRMCLFTGLSHTSTCYAMISLNEDRAFYGVPSDRVSPESYEKVGSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBE9</accession>
    <name>A0A1Q5UBE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000441">
        <property type="protein sequence ID" value="OKP09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBE9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBE9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="263" mass="29966" checksum="995429B681B96739" modified="2017-04-12" version="1">MPLVFSSEVKHYLPEEWYKHILNKSQDYESLRVVTLTRVKNLDSAWGHEYIQFIVEDELSNERARVYAERGVPKSSIDAIATGVTPITFGRESVDGVTIGFDEKGEKGRWNGPHDLPLPLESYIYTAKKPSFISLAETISWVSKKGGSYKPIGNNCYWFAYTAMNDYGEKNKGTPKTVYATIGGRGGGGLRDIISYHKFRLRKEYYRVSNALYSLLKFGLPDTNKFLIQKDAEKFNKERRDGGLMDALTLSRGYITSVKRLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBF8</accession>
    <name>A0A1Q5UBF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000443">
        <property type="protein sequence ID" value="OKP09799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBF8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBF8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="314" mass="34372" checksum="8ACB4A8159080E5B" modified="2017-04-12" version="1" fragment="single">HHPAVEDQISCVNPGVEAFDFNDILHLQDLPSSGDEDHPINCDNLGPESQCPLNFESGDLGLACTTSQQSQVGKAGSSGLASECCDPTIDPAILDDYHFQDMEPTPARKETSDVVAPSRSLGKSVRGRGMRPNSQRAMKPGRQQSKISKVAVVVDNRHMNRTGRSARASGPVTMSFSILRDQFSSLPVEERLEFLSWLFEGALSQCLHMPSRSKNASSSKGILTEEGITSSSAEQSSAGAKVVRGKNTCSSRKGLPWSFEENSLLVQLREEESLSWSEVIKRFDQRFPGRSKGSIQVYWSTTLKKQRLSLEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBG8</accession>
    <name>A0A1Q5UBG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBG8"/>
    <dbReference type="OrthoDB" id="3911301at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="66" mass="7409" checksum="09A5FA501AF93211" modified="2017-04-12" version="1">MYSCANYPRGCRGRVNRQGAKCSDCVTLNLRRPASASPFAQPRDYKRVLPSERLSDSAFKVSDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBX8</accession>
    <name>A0A1Q5UBX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000423">
        <property type="protein sequence ID" value="OKP09969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBX8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31560" checksum="1C8DB256E4A2CFEF" modified="2017-04-12" version="1" fragment="single">MTESTSQANMMFDFAAIRAQARPSTTVDRSAINADSKWIAKRESRPSCRAPSPKVITGPPKTLYLPRLCNTDDIASVLIVRRESPWDTYHPVVTYDGAGKVTIATRCSRPSRMVAIRKYPKQDTRRLIGRFGRLQHRNVLSLLECYLDVDFAYFLVDDLALTLGHLIACPTIRPAEFELGCIMVQVLNGVSYLSTFGLTHPSLTCHDILFGLDGVVKIEWCVDCTTAQAEATYIAAIPPIVMQLMIRDDKDVAANDMSSGSPIKSNIVQFLNAAKGESSLFVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCJ7</accession>
    <name>A0A1Q5UCJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCJ7"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57246" checksum="A7C1ECEF42B65DC1" modified="2017-04-12" version="1">MATPGASSDTLITPSSQIQPHCSSNLHTMSTRPADPEGQADSDLELAVLESAPPVVPKLLREASDITWQESQEASKDAVTLVRRRGRFHLLHQQQFRNSLLASVGYLELANAADFAANVWNQIPVPTFAAVLMGIGGTCALGMVFVAMQDFRLSLRNVKLLLTERENLKRLRQHHSKNTGVVQLLESRLGVSDREMGTEIVDRIVMDLLMGFGSVLVGVGTLMAIGGANPRVFKASNLLSGYIGNGLAAMFGLVNAVWSGYLIRRFHQHLKAVRASQPGDDIRRRLHNRIRRFQWHSFINGLNGLVAGAGSIVTAERWWGYVVLIPCIISLIAVNFFWRKKLGYDRPLLMDVSLTRMQLTPLLEDLEYAIAMQRGLAEPDTDLPQALVQMDSLDSMLRFIVQNRMLERYCESLTCGKQTRGLLRDLLPTTTTPHEVTISIDALFRLSSSSTANADLLRAHAKRFLQKDGVLIFTYRERHLLELLAYAVWQDQTTSTAQATDAGAGTTTPEAMIETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD31</accession>
    <name>A0A1Q5UD31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor U2AF-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD31"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="134"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="272"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="401" mass="45422" checksum="B74C34D948AFA1E3" modified="2017-04-12" version="1">MASQGASTDAPAFPQDPAEFDSDPRISWSRLDEKFILETEDGQEFEYDSGLKRWVFKVCSGDSRLYAFLASGQSGDSTVTSPSVDEELLKQQQEAYKVAGVDEDEMVNPREMKKRKLPAGDAKGNKAKKPRVNSAIWITGLPQDTKRDEIEEKFSRWGVISREIDSGGPRIKMYYEEDGTFKGEALVVYFRPESVNLAIQMVDETDFRGGQGTMRVQAAELSFKSQTEAPAKPAPRDRRKVLERTEEMNRLLTDWDDDDPLLRNNLIVPQERTVVLKGLFTLEELKEDVEAILDIKEDVRTECSKIGEVTNVVLYDLEPEGVVTVKFAQPDDAQACVTRMDGRFFGGTQIKAYIQVGREKFKKTNERRAALEDMAERGLDADNEEENQRLQGFGDWLESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDQ7</accession>
    <name>A0A1Q5UDQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDQ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="167" mass="18436" checksum="216CB970109B0F2B" modified="2017-04-12" version="1">MTPSDSSTSSDTHPYIPQYPQYPFASGFPYSPQHSAKICLRSALTISRMFEALPYPQPLSEGGSQAQHQAGGQPLPRTMPSFACCLMQSSYAMFMIFYKARVAKQLSPDVESELVSNSTEQLVEELRRGLERIIAAVSNYSFAFEALDGMRDEIQGAYQTAFPTASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE29</accession>
    <name>A0A1Q5UE29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(+) kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_4031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE29"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46084" checksum="FAAEB41269B41994" modified="2017-04-12" version="1">MEKPRIRPQLDQYDKSTACYVHSLIAGEWAVPSTHVDETQDAIRTLSDEEPNVDTKSGEEDDVVSVIDSDNKVLKPVPTVVQSRHLTKRQLSDMAWNVRKLSKKLGSIKLKLTVKNVFIVSKTHDESLVSLTRKVTRWLLSKDRDAPYNVYVERRLETHPDFGALQLVQEEPSAKGRLLYWDPKLAQEQPHLFDFVITLGGDGTVLYTSWLFQRIVPPVLSFALGSLGFMTKFDFADHQKILENAFREGVVVSLRLRFECTIMRSKARLKDPNSRALTSRDLVLELIGEEGEDTLTHTPDRVYEILNDVVLDRGPNPTMSQIELFGDDEHFTTLLADGICIATPTGSTAYNLAAGGSLSHPENPVILVTAICAHTLSFRPIILPDTIVLRMGVPYDARTSSWASFDGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE55</accession>
    <name>A0A1Q5UE55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Outward-rectifier potassium channel TOK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE55"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE55"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="159"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="355"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="668" mass="76664" checksum="A91B33BDBC00CCC7" modified="2017-04-12" version="1">MQNEFPPLAAAANATTAKLSRWERFSSRFHMRPPEDDEPQSWWIASTAIPLVAAAAGPLANVMSIVALVMPWRNTIISREKGPAGTWVQEGYSDPHCPPTPPNELYSQAYWSAVIAAILYFILGSLLMINMLGYFLGKYPQHFSLTDDQRTLILQMTGFVVWLLIGAAIFQRVLEVSFADALYFCDITVLTLGFGDITPHTAVGMGLIWPYAVIGIVMLGLVVGSIHQFAREVHYDNVVRKHIEHKRQTTFDRSVTFEQFRTANKPSEKDIVIPKSAGHRSRTHRNRHHRHNQHQHHRHGPILNTINALASSRRPRLLVMREEKDRFDAMRAIQYETMRFRRWNDLIISIIVYGIVWTGGAVVFWRLEDMSYFDSLYFCFCSLITIGYGDFTPQSNAGRPFFVMWSLIAIPTMTMLISQMSDTVVAGYKHSTEKFSDYFVMPRQGAYKGILGRIPLLRQWIQIHQEKQRLRRGFEVGAEADEAAETEDRASTASRSQERAPVVPLRPRPGDDHPLRTIEELARDENPSPFELAEQLAFAIRRTTHDAREGKRKRYTYEEWVEFTRLIQFTDPHSRPSSSSADRNKPFHSSTSVDEDEYGVLNWDWIGENSPMLAHQSEPEWILDRLCESLVRYVSTQEQARVIARGQIDDVIEEPTLRKERDLGIEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEC8</accession>
    <name>A0A1Q5UEC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEC8"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="69834" checksum="C8CC6DF4C07600CC" modified="2017-04-12" version="1">MSATPRKPGTPGSSSKSSTADPPSTNGSTTRGHARSPSAATNGLNRSPSLRGSTPVSARAAARKPGRSNLSMSNVPRINNDPSDEEARAQNAALIEDLRAQLQKAETASEQYQKQLGVLQMRLDEAVSEQGKLEDQAHEKDTRLEALNSELRDQARQIRDLEQNHELERNAMLQEKEQQTSREEELQATIQRLKDSVAQKSMPVNAEGERQISRSSSFRNRSSPDVDGQFAPSSHLERSPSRNNSNLLLQKDKLIESLRLELAEHQIKLVEMENAGGGRQRELEKELLEARMANARLMEDNESYQLLLSEKTLTGDFTKGDFMQHAHPDKQSSGGLGSLADELESVDEAPETEASGKLEAEIKALRDQNKALTLYIERIISRVLQHDGFEHVLDRNEDEGGSKVAKAGEKELPPTPPEKDDGPSQSFLQRAKSTIAGPPRSQPRSRPTSMMPPPSLPHTSANENPDTAPSIPIRTQSVRASHRRTRSEQVDPNAASVVGAMYRGRNSGGPMSPSAMGPGSRQSMFSGAASYISSRAPSMSSQPDRGGRSSSPSVISDINGDTSSTGATSSPPRSSSGMNNYTGAVMTQNKLRPLRLVSDAAKLEEEEAARKKANRASWIPGWFNRPTNPDEQPQTQSQPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEG2</accession>
    <name>A0A1Q5UEG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEG2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="150" mass="16988" checksum="DD0BDB963A10EDD2" modified="2017-04-12" version="1">MRMQYFGQMLVTQRYDVPQMAYLYNLFARSSKHKDLHWPDTEAFIKIRGESHLFIGVRPMNVIDSLNRLELAAGVSPFADFARGARKKGKYHKSGGKTRRVLKPTTTVANMFWARYIGYSAQNLNATLNISKILYQISPGLGTAATKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UES4</accession>
    <name>A0A1Q5UES4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UES4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UES4"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="486" mass="55716" checksum="300A3647F18827AD" modified="2017-04-12" version="1">MEYIQPRHLYTRLLENAPWKSGDPNVKGDPRKSVKWIDGLRGIASFLVVLTHLARAWDYDLFSPRDDEDATPRILQWPILRIPWQGRLGVTIFAFLTGYVCALKPIKQSRNGDHLGSFTSVAKSAFRRPPRLIFPATIALIISWVMAQLGAFIVANRSDCWWCRYAAPDLADSFWKEVLRLFENFLGVWTTGYMAYDDHQWALLPLLQASMLVYILLCATMFVKFRWRLAIYLGMFLYFHQDAAPNTETFQMQAIYGMFLSDLSYETAFKEFVQRHKWGRRAVSATCAITGLLICSYPGEHPEWATWSNYMFELAHYIFPPEVNIGKRYSAMGVDLIIFAIYISPSTKDFLANRLLLWLGKQSFAVYLVHGTLLRTVLCWMLYGITGQPWDGDVVDGNGQPILDENGEPLHPHWIPIRAPWVVAISIPSWIALVYLCASLWTSYVDPFCAKMAQKLEKLMFEEDEKSPASLPLTSMPMTNMPMNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGM0</accession>
    <name>A0A1Q5UGM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000275">
        <property type="protein sequence ID" value="OKP11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGM0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGM0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="342" mass="37938" checksum="CD8190B543223DB3" modified="2017-04-12" version="1">MIGFSGALPKYGPYTLENLGLRGRYPIQTPHLLLVKECPWATPVKTIAVSLALQSQFELHTFLEQAFKFLCPFLGVCEGVQLDVRFYSLRNIVTSLVKRVPLERCCCEACGRTPMLSNKVGTIFDYCKGKIRWGYEVDDTSKSIKGVKLLLDEKQTYNHGPSKKAESVLQNKKKSTISASGKYVGMLVAHVKNILKRRFGTALQTMDLQFVMTVPAVWSDKAKDATMQAAILAGIPSAALFLVSDPEAAAVYAIQTIQPNTMTDYIEPNYQGPMDCEDFGDMDYCIPIPGIDDIPTINLKGGILHMESNDVEAIFHPVMKKFAELVADQRLKVKQTGNETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHA0</accession>
    <name>A0A1Q5UHA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0311 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHA0"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00775">
        <property type="entry name" value="UPF0311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="17748" checksum="FE36D33CB9F8191E" modified="2017-04-12" version="1">METLAPPPKLTHLFTLRCAVDPPMEIGNGPYGRRRCVPIMSGSVRGPYFNGEVVPGGADFMLVEDNQTTHVNTNYVIKSDDGALLYIRTEGTRAGPPQVLKALMEGGPVDPSKYWFHLHVKIETGHEKYKWMNDRVIIGRATRAKGEVAYDAYFLENDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHH5</accession>
    <name>A0A1Q5UHH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHH5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHH5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58199" checksum="CBA945C58317B9A5" modified="2017-04-12" version="1">MSPLSPVLTDFFASHKNQFYLVTQEPMLCCTILMISSRHHILPGVGGRSRAFFIHQRMWQHCQHLLMRLTLGQEKISKAKTRNIGSIEALLLMSEWFPRHLQFPPETDGWDSDFIMTNLDARDPPLPVEEIPVSDTWKQDVVEPTKRFEHMSWMVLSLAFALAHELGAFDPNARMLKAGDLLGFDAEMYLQHLELRRQRLPSLLFVFINALSSRLGCTSPMPSDVGLMTPDPALLQLDKRGNEWLSFMKSWRELSKLTSSIMQTLFPLMGTSLATGSAEAFFSILEQKQTLLANWRQRNLSIAERARQLNMTAREYGFIEEVIDGCCQTLEKVATLGNAGSLYFSPMRLLFRTISSSIFLMKALALGVRNSKLQEALQILDRAIESLQDNKEDDNHMKLRYATLLNTQAARLRRSLISSVPTLEAPTVDSGLLHRPLQSLEIYPSMTSALNNDHEGLSNLSGFDPEDPLDFDVNDWLSLPFEPSMVPFGPGEGDSWARLDGVDLNLEFLWQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHK0</accession>
    <name>A0A1Q5UHK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHK0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHK0"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="171" mass="18081" checksum="D4DC99BFFC606D78" modified="2017-04-12" version="1">MPSSTPAGGASATPDALESDLLTKLSATSALEDLQESLLSSLHRVGWTEKITSLATELLRAGRCETFDDVMEAIVASAEGRTHPALGSKNTAQNGDATSNGTKEAKSNGTKKGHASGGSKSDTPYDPVKYIEEVDVRIPEPIVDEGVRGLKDILREMVDLEDENTPNGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ80</accession>
    <name>A0A1Q5UJ80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ80"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13302" checksum="F8349FDFC31E0B4C" modified="2017-04-12" version="1">MATEKKDKMEAQIKSVDMTEDMQQEAIALAIEAMEKYHIEKDIAQHIKKEVRCRPSIRERVLPGIALSAETLEALSLTVSVSSLAMVKYTRLTPSAETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJC4</accession>
    <name>A0A1Q5UJC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000188">
        <property type="protein sequence ID" value="OKP12571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJC4"/>
    <dbReference type="OrthoDB" id="4361886at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012524780" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9579" checksum="4651F07FA948ADE5" modified="2017-04-12" version="1">MKFFGLAVAFLPILAAGAPVTNPEAEVDAELDLGKRASAQDCKIVNVDHYVNCRYDAKLDAGAIFGFPKGDRLTFACWKHGDCFNGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJE5</accession>
    <name>A0A1Q5UJE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJE5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF32">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="52820" checksum="CB2B2038007D0295" modified="2017-04-12" version="1">MLGSPWLDGVSNLTTFDQALSNYVANTYVTSKYADQLGCDGLNKSAMNDYYAQYTTSVICSGLVQSSKNDCSLSSAQSEPLCAETCALMATSEQEIMVNKELCPKTTKDYMKEIRSDFTICSNPADSLTGSCVSGSDNEPNNCGFRTNTIGLCTYCASSSPNSTDTCCSSSNATSRCSGVTIPSSTATLQPIVTTTAAAAAGASHGLSGGQIAGIVVGSVAAAAIIGALLAFLFICTRRRRKSQPDAALNQPNPQRKGATPPMQQQQPESPTGYNMVPGGRVARMSALREVPSSSSPAYSRTSAPMFGGTKYSDSSDSEAMGASPGAMSRRIPPVTGKRHGSLSSSSALAGLDSDSSPLSGTAHQFSSPEGVTSGQSEQLSYFRDYYSQDDIQPGDKVAALWAYSPRAGDEFELDRGEMLKVIGIWDDGWATGVRLGERAEDYDMHREQRDSGVSNGSHRPGPSPVPSGEIKAFPLVCVCLPQHWRKIIDGGVQEDDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKR2</accession>
    <name>A0A1Q5UKR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="52" mass="5399" checksum="9F46103B7AE1A1C2" modified="2017-04-12" version="1">MGDMDLSWLTRFSSPSESFDANANMANISYASTAPAATTGGQGNNPVSSQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL75</accession>
    <name>A0A1Q5UL75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor dre4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL75"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000035">
        <property type="entry name" value="Putative ff domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000049">
        <property type="entry name" value="Transcription elongation regulator 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="655" mass="75368" checksum="B815F2960FD337BA" modified="2017-04-12" version="1">MKFQATRPGASSVIRQARTTSPHQSFKSGFNSLNFGPRELATLRSTLEILQLLCLDRHTLPRHLFPRGGRNTERLQVCPPLAKSGKDLTNCDELSGHLYYYNAATKQSTYKRPQAQDSQLVQLALPVPPAAESSQSLPFYSPDTLPPFSSTPYGPAGHAPGTAQHGQHQQHQGQGRGGFRGGRGYQDRGRREPQDKPKTKHPIPDCAPWVLVKTKLGRRFVHNPQTNESFWKFPEEVLKGVAEYDRLEREKKERRERGEKSEEPEEAKEEVVGVPTTSRLERDNATHEGLYAGAEDSDEYEEVEVTDDEGEDEEGQFSKRARTESPGRQDQPMEFTEEDMEYQLAAMGEDYGLDPGEYGEPGEDWEEGAEGLPLTEADAEALFRDLLDDYHINPFSTWEKILEEGRIIEDSRYTAPSNMKTRREVFSNWSKDRVKDVRAQKEKQEKQDPRIKYLAFLQEYATPKLYWPEFKRKYRKEAEMKDSQLSDKDREKLYRDYISKLKLPESTRKSELSALLKSAPLHALNRSSNLEALPSTIMTDLRYIALPTKIRNPLIEAFISTLPPPPEEQMTAEQQEEHDRKQREREKRERALAEREKRVEEDKRRQRGDLLRGRHLLREGEAEIAEAMKVRKDGLRGYMEVDQTPAKEQEKPSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULR5</accession>
    <name>A0A1Q5ULR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GATA zinc finger domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_909</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULR5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULR5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000043">
        <property type="entry name" value="Sexual development transcription factor NsdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF123">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="440" mass="47219" checksum="3529AF212DA2F920" modified="2017-04-12" version="1">MYAGQSLPYSYAPTTSAPSQPGYISPPESRRILEDDKEKPSGRQSLPSIHEALGNDNHLPYPAPTSAPPPQPGHTAPPPSHLIGRSGAEGPSGPPNPFSNGPATGSLMREPGYPAHPNQIQADASRTSLVSINTQESRNTSLHSKSPTQSAKTGFTSVSGSQNSSAYDYSAPPSAGSVASPNGYSHFTPNYSFPPSQQHQQPPPPPGGPSYPPAHYDNRAYMGAPRVEEVKGGFVGRPMPGQPHSDSVKRHLDVYDVETSLNEISELSTRTLDFSRHYAALAHQTQRSGPVLGSLPTLNEVEDILHLQRRNQDALIRIRTAVVNQEQALAEQMAQRKAFKPGEDEHMAMYQEEFKGAGGFAGPDSKKRRGKAAPPGRCHSCNRAETPEWRRGPDGARTLCNACGLHYAKLTRKMGANKAATLGSNLKPKTVLDSASPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULW1</accession>
    <name>A0A1Q5ULW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="11">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULW1"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000003">
        <property type="entry name" value="Dolichyldiphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="12">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="25626" checksum="092103C9A8AAEEB1" modified="2017-04-12" version="1">MGDTPLASLSLTHVHYNPEDPLSFASAWLALLPQALVVSYTTLVWATREVEVVLMFAGQLGCEALNFVLKRLIKEERPKEMFGKGYGMPSSHAQFMTYFAVYLTLFLVFRHSPTYAGSYPYSDFLLRTALTVGLCASAVAVSASRVYLSYHTPRQVLAGSATGLVCALGWFLVTGLLRSTGWIEWATDLTLSRLLRVRDLVVSEDLAEAGWQRWKAQRLKQRHSKAGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM04</accession>
    <name>A0A1Q5UM04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_717</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM04"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM04"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="81"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="42244" checksum="4738EFF3B22D88C3" modified="2017-04-12" version="1">MSFNLPRSLSRTAWRSYGTVQGSPSAASIASRVPSVLVEATSATAPRTNWTPEEVSAVYHTPLNQLTYASAAVHRRFHDPSAIQMCTLMNIKTGGCSEDCSYCAQSSRYQTGLKATKMSPVDEVLEKARIAKANGSTRFCMGAAWRDMRGRKTSLKNVKQMVSGIREMDMEVCVTLGMIDENQAKELKEAGLTAYNHNLDTSREFYPSIITTRSYDERLRTLANVRDAGINVCSGGILGLGETDADRVSLLHTVSNLPSHPESFPVNALVPIKGTPLGDRKMIPFDRVLRTIATARIVMPATIVRLAAGRIAMSEEQQVACFQAGANAVFTGEKMLTTDCNGWDEDRVMFEKWGYYPMKSFEKLGLKETSAPAPPASQPETAAPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMA4</accession>
    <name>A0A1Q5UMA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMA4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9316" checksum="B2E7D95DC93D73A8" modified="2017-04-12" version="1">MTGRALKEDLRAFGGSKPSLTLTGTTASSTEIPVKTNLSTALSHQPICSWKEARSFDQRVVSATSEKLSIYVLKESSFVVDILRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMA6</accession>
    <name>A0A1Q5UMA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aflatoxin B1 aldehyde reductase member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMA6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMA6"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11239" checksum="56BE2719D13754A1" modified="2017-04-12" version="1">MFSALEIMEPVVEKYGFTLVEVALRWIVHHAALKGSYGSDTTVVGFSSFGQLQPNLADIEKGPLPFGVVHCLDQAWYVTKADAANFRHGELKYEYDTLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMH5</accession>
    <name>A0A1Q5UMH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMH5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMH5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="160" mass="17907" checksum="7156BED538BF55B9" modified="2017-04-12" version="1">MRTYDDSFSGQKIYPGKGKLYVRGDSKIFRFQNGKSESLFLQRKNPRRIAWTVLYRRQHRKGISEEVAKKRTRRVVKHQRAIVGASLEQIKERRTQRPEAREAARKQAIKEAKEKKAAASAAKKADKAKTAASAAKGGAQRISSKQGAKGSAPKVAAKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMR6</accession>
    <name>A0A1Q5UMR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMR6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="55" mass="6136" checksum="8CC46E7D91C6572D" modified="2017-04-12" version="1">MASVPPSTDTIAELPLRDIIACRSHMSDNLMTWYTWAVFARKLAPSTQNIPASMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMT4</accession>
    <name>A0A1Q5UMT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutathione transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_528</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMT4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="775" mass="85840" checksum="4C6110F5A38FBB7A" modified="2017-04-12" version="1">MKREMESQSDAPQPQHQTQEQQHPDSPVGSSIGEKAIDSPPFPLQDCSSKHHDDDISVLRDRNAAQVLSYDADDSPFPEVRAVIQPIDDLSLPVNTVRMWTIGLLFTIVGSGLNQFFSLRQPSVTISALVAQLLAFPVGCAWAKWMPLGILNPDRHFNIKEHGLITIMANVSIGSAAATQIIEAVVKFYHMPSHGGFEVLLCVTTQLFGFGLAGMAARWLVTPASMIWPQVLSNAALLTTLHSRENAIADGWRITRLRFFLVVFLVGAIWYFAPGYLFTGLSTFSFICWIVPSNVVANQLFGQITGLGMSVLTFDWAQVVYANQSPLLVPFWAGLNVMGSFALFFWLICPIIYYTNTWYSAYMPLLNSNTFDNTGNTYDPSRIMGPDGSVNQTAYREYSPMFLPAGYAITFGVAFANLTGIFVHIGLYHGRDLWQQWKGTNKQDVHARLMSVYPTVPWWWFAGVTALMFVLSVVTNEVWHTGLPVWAVLVAFVLPTLYFIPVGVIKALTNISSNQLNLLSEFIGGYAFLGKPLANMVFKFYGYVAVQQGLEFVADMKLAHYLHIAPRTVFAAQGFATLIGAIVQCGVTVFMITRIDDVCTSDADGNFTCPHGRVTYSSSLIWGAIGPGRLFSPGQIYGNLLWFFLAGPVVVIITYLLGRRWKAVNYISWPVAFGAMSLVPPATGVSFSSWWVINMIFNGLIRRRKPAWWSKYNYILSAALDCGVAVSTVIIFFCITLPAGPLNWWGNTVYTKTADGRGTPCNLSMVDIKNLCFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN95</accession>
    <name>A0A1Q5UN95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN95"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="7305" checksum="EB6826B1B41D778D" modified="2017-04-12" version="1">MANISPATPEVPKVAIVTTTTATSVATAAVTTETTSSPTIRRVKEELLEISPASATSSTTTSTVPKVSATRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNK3</accession>
    <name>A0A1Q5UNK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNK3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6908" checksum="CFD7367C873C7F47" modified="2017-04-12" version="1">MSVRQYWLSRFLQKPGTTELIGVVHQYFPSVLESSTTNTSDANRGYSWEPCSRRRKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNN2</accession>
    <name>A0A1Q5UNN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purple acid phosphatase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_342</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013089815" evidence="3">
        <location>
            <begin position="20"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="94"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="389" mass="43034" checksum="C7C7BBF4CAE3AA09" modified="2017-04-12" version="1">MPAMSRIALTLGLALGASAAPNSIVAPTGAEKLTVGLLGDYGWTGWQPLPLDFCNTALPKLQADGVTIPRDLQNDCDPGDRADIANATIEETRTAKYIEKVCLKKNCSAFMSVGDNFYDSGVDFTSEGIQRFYEGWANMYVGKAFDGKPWYQALGNHDVVAGKAGVDFQTRIAPLMEDRWYFGNDNLPYYTYDLKGSNWTATFAVVDSDCFINKYQQSTSVYNTDYVIECHKTTQTQVEFLRKAFAESNATWKILQIHHGFISSSTNYTELAPLMDIVRENNGVVINGHDHCMAHYQFNGTNFVLTGGAGYAEAGDCNYGVPMGPFTKWLGANAQQAANGFVTLDISYNALHFEYYARDMQLKGADYYPVAHDMVPSYSFDVTKHATKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP20</accession>
    <name>A0A1Q5UP20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein sum2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_73</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="550" mass="57716" checksum="EDD7655424FF988E" modified="2017-04-12" version="1">MPRARCLLSPSYVGTLHEINPEASTIALENVQSFGTEGRRKNPAEEVPPSSTVYEYIVFRGSDVSDISIADEETKENTQQEPPRVPDDPAILGNMSRPGPVPNPPMGSSAPGLPPQPSSQPPQGAQQTPPGYPPQQPFPQQGFYPPYGQRFNGPPPPFPPGPGGPGGFPGNMPYGAPPPGWFPPPGHGFPPGGPGQFPPQMPHGTPGQPPQQRPGPPGVPTPQTTSELPGGDQKPTSRNATPAAQNAPTPPVESKPTVAEAVHGSGPAAAAQKSGRVMPAIPMAAPRPVAPPHSVAPVDATAAASQAVAAAMAKLPQPGAQKKPGQDASVDALSRKMNDMQPYGGPRAPRGGHQQHQQHPHHPHHPQHQHQQHPRGGRGGVRAPSKKIEVPESDYDFATANAKFNKQDLIKEAIATGSPAADAESHDVAHQPEAEVNDPAAATSHNLYNRSASFFDNISSEARDREENTNRVGGREWRGEEEKRNIETFGQGSVDGYRGRGRGGYGRGGRGGRGYGGRGRGFNNNRGYGGRGGSRGGRPPSQSTGVPSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPW7</accession>
    <name>A0A1Q5UPW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase DltE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000087">
        <property type="protein sequence ID" value="OKP14513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28738" checksum="86FD772467072B65" modified="2017-04-12" version="1">MAFPYRKILILGATSGIGRALAASLIQDGRFVIAVGRRKEHLDSFVQEQGTDKAVSFQFDISRLDEIQSFVKSPSEIDRLHTHEVSVDVASVTSSHPDLDCVFVNSGIQRRSVFSEPETISMSDIQEEMTTRVSTSSNLALVPILRCSNYCASKAALHQWILCLREQLKGTNTKVIEIFPPIVQTELHDAKHQPDMGQAGKSFGIPVEQFTEETMERLQAGDEQIPVGLSKIAFESWEQQRQGAFHRIVELMKSSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ75</accession>
    <name>A0A1Q5UQ75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and KH domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000074">
        <property type="protein sequence ID" value="OKP14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A2" evidence="4">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="482" mass="50874" checksum="20DF090E7E822168" modified="2017-04-12" version="1">MDHAIEGNREDVILHGLIMKLFDVYERPYTTWIRLYNPDGSRDQLRAEMIQIENQKERPAAALYYASLGGLEKEVKALIRQGEDGNSQGGFFGNALQAASHRGHGKVVQILLDQGADINIQGGNYGNALQAASQGGHTTIVQRLLENGADINVPGGFYGSSLQAAAQGGHETIVQELLSKGAHVNYQGGPFGCSLQAASQGGHRRVVHMLLDKGADINYQGGPYGNTLQAACCRGHKAIVQDLLNKGMNVNSYGGEYYSSLQAGCHGGHEDVIRILLDEGADVNVQGGIHGSALQTACHGGFGKIVQMLLDKGADINMKGEPYGCALQAASHGGHKGVIQLLLKQGADKDVNYQGGKYGTALQAACQGGYTEIIQILLDTGADVNIQGGKYGSALQVACREGHENIVRTLLNNGAAINTQGGLYGNALQAACRGGHKGIVQMLLNKGVEDINAQGGVYGSAIQAASSKGHDMIVQMLRDYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URD1</accession>
    <name>A0A1Q5URD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">10 kDa heat shock protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URD1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="11712" checksum="2DA426162A715B2A" modified="2017-04-12" version="1">MSVLRNIKSLAPLLDRVLVQRIKPEAKTASGIFLPESSVKEQNEAKVLAVGPGLLTKDGNRIPMGVSAGDKVLIPQFGGSPVKVGEEEYHLFRDSEYVHHVSIPAQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URD5</accession>
    <name>A0A1Q5URD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URD5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="315" mass="34984" checksum="566A0E88F3F18D45" modified="2017-04-12" version="1">MPFAQLVIGPPGAGKSTYCNGMHQFLGAIGRKCSVVNLDPANDKTSYPCALDVRDLVTLEEIMDEHKLGPNGATLYALEDLEENFDWLEEGLKELGVIHLIDSYALTLPSMYISALLLSLRAMLQLDLPHLNVLTKIDNLSNYTNLPFNLDFYTEVQDLNYLLPHLEAESSRLTNSKFSALNTAIIDLVEEFGLVAFETLAVEDKKSMMNLLKAIDRASGYAFGPAEGANDTVWSVAVREGMGGMDVRDVQERWLDAKDEYDALEREELEEIAKMEEKARQSAMGPGMDDLDDDELANWSGPVPDSGITVRRKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URK2</accession>
    <name>A0A1Q5URK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URK2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6641" checksum="791487EF2A797380" modified="2017-04-12" version="1">MSKESKKRAERFYVLKGEATTGMPMLVRNVELDLACFGLHRVEAFLRPSAAMNANVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URY0</accession>
    <name>A0A1Q5URY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000014">
        <property type="protein sequence ID" value="OKP15231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6149" checksum="1914907BC2C9CE3D" modified="2017-04-12" version="1" fragment="single">MGGAVNSAAAAAEGASTTMTAAIHDADDKMKEEAQKLSSQLFQYYSVGLWGYCMKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SND1</accession>
    <name>A0A1Q5SND1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SND1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SND1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000032">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="862" mass="98390" checksum="B412490C03EEDC61" modified="2017-04-12" version="1">MQKLKQKFEHEVDHLEEKFRDSHLHDAKASATHLKHKVGKFFNIVNPNHRHDEEHEQATDRKRSAIAQSHRYQSFAPVQEGNRVKWYVDALDYLWAVSEALEKATETIYIADWWLSPELFLRRPPAKHQEWRLDHILKRRAEAGVKIYVIVYKEVNQALTCNSAHTKHALQNLCPEGTPGHGNIRVLRHPDHNVFENAADMTLYWAHHEKFIVIDYAVAFIGGIDLCFGRWDANQHPLADVHPAGLRDDIFPGQDFNNNRIMDFQSVQDWQSNELSKANFGRMPWHDVAMGLVGDCVYDIAEHFVLRWNFVKRDKYKRADNVDWLMMEGRLGDDEDLVAVQRPKYPCGEYIQHPLSPLSSKPRGQQGSVRAQIVRSSDDWSSGILNEHSIQNAYCEIIRNAEHFVYIENQFFITATGDQQRPIFNTIGRAIVDACVRAGKEGRKFRVIIVLPAIPGFAGDLRDSAATGTRAIMDYQYKSICRGEHSIMGQIEKTGVNPKEHIFVFALRAYDRINKTPSLEELEKEAGVTYQDIQRGIAESIMGESVHPSVGTEGDSNEKSYDADDAQKQKNLRNLEKFEEQVEKRKAMEGDGSKDSVAHTTMLNGGKMSDETWEGDPEAEKENIVQEELYVHGKVCIVDDRIAICGSANINDRSQLGSHDSELAIVMEDQDFIDSEMDGKPYRASRLAATLRRQLWREHLGLLPAQNYDATGHPNAQPPDVCLNEILEDTHNEFVTDPLSDAVWNTWTGQASVNTETYRMLFRADPDDNIKTFEDYDNFRPRGSHKQGHLFDPYLPVAEVREKLDRIKGHLVWLPLEFLRDAEMAEPGLAVNQITEPQSESAKCSTYSGCLVDIRQLFPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNJ7</accession>
    <name>A0A1Q5SNJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNJ7"/>
    <dbReference type="OrthoDB" id="10597493at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="12309" checksum="1979846CB0C1F601" modified="2017-04-12" version="1">MSSNNGHKEVSQGTVTRYQQTLETIYETSEEMPPTHQVLSAKPLMRSRIPRAQRKPPQREVFMSEEAMVRRAILAELEEIDKHWENLAKLYATLLELMRKKRTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNY3</accession>
    <name>A0A1Q5SNY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Forkhead protein sep1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNY3"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="193"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="193"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="593"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="686"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="711" mass="78016" checksum="D73776C76D35786D" modified="2017-04-12" version="1">MGSTRPALGAHNYSPALALSAQASIKSQPHLHPSPLPLQPITENPLLPLAGTHRPSPTKGRLTQGSHPGRKLGFVPITAPNPPMFTTDSPTKKPPFPIYTQSSMPPQSALFTTFSSVNPDSSKENHHAEDPSNGSFADFPEPSYESKVPMKRTLMEAAPLKERPVKKQKCEDAPVHQLPEPHQMPTIEDDGTKPPYSYATLIGMSILRAPNRRLTLAQIYKWISDTFSYYKNSDAGWQNSIRHNLSLNKAFIKQERPKDDPGKGNYWAIEPGMEAQFLKDKQVRRATMSSLPLPAVPQREIVPQPQSATTTTWMVPPPPARQPPPPKVSARNEDLSSDATLPASDPALQEDTGDEAPHPPVKRAAPVRSSPLQAIRSSPPIAPPRFSRPGTPPTPTHQVGPTPAQRPRKRKSISMNDSGYFSSLESSALRPNKAGHILTSDLDIEPPRIKRGRAEEEIARIRSSSHDISPGQPPVRKDGRTMVGSSPLRGEYVSMLPPPLTPIIKFKKPAKPPPSVSPNTNLRNHRRKIQQMVNSPIKHLGIADDELPWSPAFTLHEESFMTPADHFHSTFDVFADASADACISSAAFGSPEKRSVKRARMDSGSHALHDISNSTANSRVHMPSLTRSKSSIFPESPSKVSDGVRLGDASQDDFFSFHLFDESNDSPTEVDGVDLLQGFQKIGGSSKDDMLKHKTLHPRPHLSNRSNSTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQK9</accession>
    <name>A0A1Q5SQK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQK9"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="793" mass="88502" checksum="DDACB2DE2EED0CD3" modified="2017-04-12" version="1">MPLFKSRKSKSPSNPPSTPSPPSRYPARSVEQLVHPAFVAPPAPINNNSNHRLDEYPDRHVSDYRLNYDGPATATDLPPPPPSHQRPPQLQEPTQSSSASSLHRSQSQRQPHLQQRDRPTVSVVAPEEQPQPRRSKKSLFVRPSSGFLERKVSVKGKSISHPISQPTSPQHSPHNTLGPTNEDQYQQHLPSYSDNSSPVSNNPSYDPRAASLAYQQQYQQQQFLRSSRDNLEWPPQQQQSQQPPPPPAHQSHTQSQSLSLQQPLPLHHRPLPSPLERSNTDPSLLEQPSSRPSPTDAPPESPRYTPDHLGHRGQQSQSRFQQDLVLNSRPPSRQTLEPIAPVRLQVHPDAMQQASTQVPPQSQPQQQQQQQQQQPPPTPLANERAPGDSDRRGSTVQTMPEPGRGTPTGTRTLEDPSEIDVRALLQKHEELQTKYSKVKRYYFDKEAQVQHLQNTVAHQRMAVSRTVLDDNEYANRFTRLDGAIKDLAFSVRKDWRGIPTWLHGLVTDDATTVGTKEMTAVGRAVISRWLVEEVFQRHFHPALDPTLSIQLKSIEMNLRRQQMRPSTDEDRENAIVRLSNWRRTTFDGLGDTLSTPAAQEHRAELVEHSTAELASFLSSQLHDPALPGLEAGVRMIIENTINITEKIPLEARDVCVEYFPPNITFVEGYMKVEGGLPPLTHQPPPPADQEPDDSAAVEDDSSPASNSTGPGDIVSAPTHKPQKKSVFGALMGRKPAGPAPTRPSAGATHEEKPAPTEERETQPRIRFASFLTVEVRGKGPPMVLVKAPVWMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRG4</accession>
    <name>A0A1Q5SRG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 306a1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRG4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRG4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="389" mass="43878" checksum="DE0133BDC4A0174B" modified="2017-04-12" version="1">MTGDAEHRERKRMLTRPYTNSYILISPTLDDVLSRVSQRLKEAIISWAKTGTSVDVYQQAKCCTLDVASGWLFGSDNATDTLRNPAFENDLTALASAGSKIITMRTSLDWPLTYFENWFGNKLPDPEITSRWQAWLTQVIAHSYRWHSTNSLSTPSLFDHFYDSFKAANPEMSRNEMASLIAVECDDHLSASHLGLGTLLSYIMYELSIDQNCQRALRQELLTLAKPSDRSLAHRLADLPVLDAVVTETMRTRAPCPGPFPRVVPDSGCRLAGKFDVPGGTIVSSSAWALHFNPVPFPSPEEWRPRRWLEADENAVMEMRRWIWTFGSGARMCIGTHYSMRVIKELLATIYTDYSTCLDDEFTGNVEQQDAFSAGPIAGCLKLRFRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSE0</accession>
    <name>A0A1Q5SSE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSE0"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO90872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="642" mass="70444" checksum="CC4E4F8AB70E28B5" modified="2017-04-12" version="1">MAAEPVANGSGANNKKVAYFYDSDVGNYAYVSGHPMKPHRIRMTHSLVMNYGLYKKMEIYRAKPASKYEMTQFHTDEYIDFLSKVTPDNMDQFSKEQSRYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRGKCDVAVNWAGGLHHAKKSEASGFCYVNDIVLGILELLRFKQRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGVGSGKYYAVNFPLRDGINDASYKSIFEPVIKSVMEWYRPEAVVLQCGGDSLSGDRLGCFNLSMRGHANCVNFIKSFDLPTLILGGGGYTMRNVARTWAYETGILVGDNLESELPYNDYYEYFAPDYELDVRPSNMDNANTKDYLDKIRNQVVENLKRTAFAPSVQMTDVPRNPILDGMDDEADDVLDDLDEDENKDKRFTQRRFDQYVEKPGELSDSEDEEVNAANGVRRQPGTIRRRNQTNYRNIDAADSGLDSGMATPLDASSIADNEMDSALDAKMTDVPMTESGAVTGAEGQDTPMADSERMAVEGEDNGTSAAVSQQPSPPALDEDTAMEDAVAVAEEAELPGALDTQDEKKREVSSAADETIKAPLSPSGAQPVSKESSVPAADASATEPAPATGDSESKPASGVTTEEPTKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ST03</accession>
    <name>A0A1Q5ST03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000754">
        <property type="protein sequence ID" value="OKO91120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ST03"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ST03"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="10190" checksum="81BBC6AF051C0999" modified="2017-04-12" version="1">MSTSQYQNACHQRFNTEREARGFIEDWNDAYADAWRWEIRKGLHDGWKAKSLKFDPESALAKMGSEGDTVESPIMNLKGLNLEKEPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5STY8</accession>
    <name>A0A1Q5STY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000747">
        <property type="protein sequence ID" value="OKO91477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5STY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5STY8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="122"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO91477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="24765" checksum="67559C6D202DFB33" modified="2017-04-12" version="1">MTTSPRSHRDFASPASASMIDTRGSVSTPRAQPGERRESLELRELQTREDEEQLGYSSPSASSGEDYRVTTRRRSTQSTTVRRASDACKGKGKGKEGTWKSNRIAQFWTQHVTLTVPQRSNRDHFALERTLLAYIRTSVVIAMQGVLIAQLFRLQQPGDRLKFYVAGKPLAVTCHCVAILVALIGAYRFWRQQGAISLGKVHAGGWELNAVGILICAVSMRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYI0</accession>
    <name>A0A1Q5SYI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000726">
        <property type="protein sequence ID" value="OKO93078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="124" mass="13693" checksum="66FA8E2D15C7F5BF" modified="2017-04-12" version="1">MPIICIGDYLSPDDLPATIQQDNLHLISAESDATSKPLRYDVVEEKFELWSYADKEEEAATISDIEASVNPKNRVLRNLTTSQYVLEDTLPSGITFSHIVLIRICWSSESSTGIAGGEYLAKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYW7</accession>
    <name>A0A1Q5SYW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="11599" checksum="4562ECFB3E879E03" modified="2017-04-12" version="1">MCEHLQNEKFKDTSMGHLTTIALALRWEILIPCDKLEVAGQGTRDVVCGDVPYRVATLQRLLLNSDSTKGFAPWSIEVCLSNCESKVSIVGCLQSLVASILYSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZM5</accession>
    <name>A0A1Q5SZM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZM5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZM5"/>
    <dbReference type="OrthoDB" id="3926760at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012592438" evidence="2">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="319" mass="34304" checksum="EBF38A8DA74FBECC" modified="2017-04-12" version="1">MPAPIAKGIIVTVSVLVAAGVAVYQSPQFQQWVTTSRRKIALALHNLGDEIQPRDSTSPLREDISMTEEVGEAAEERRRIAKAEIMRRATLLGSRRKSKDSQQHLGSFDTLVDVDGNLRSSSGDLDQSDANPAGHSTGVDTGVSQPVHRGMMSNEADSPRTGQSQLHLDIRSETTSNHPSESIIQFTPTSEVPSELLFDPFADSPVRAQTPVSVAASSHTEGNDQVYYAHPDLQSNFGQPQDLLTELDDFRQDNQFQHPVSSAPSIAGSYGHIDGINDLSSDGTLSDLGGHSVGIATPASWSEVGSVVSNDDAEHHHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Q7</accession>
    <name>A0A1Q5T0Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Q7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0Q7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012231445" description="Phosphoglycerate mutase family protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11538" checksum="78440915E1A01E1B" modified="2017-04-12" version="1">MLLRSAFAYLFFGLAAVSARTPPKVYMIRHAEKPPNRDDHGLTLDGIKRAQCLRDIFGQDSDYNIGHIMAPTVKWSESRAFDYCRKALWSRDDTFKQPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0W4</accession>
    <name>A0A1Q5T0W4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosome quality control complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0W4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0W4"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="732" mass="82372" checksum="280F1CEF0B189A30" modified="2017-04-12" version="1">MSSRAIRKLQKLREQELLQQQENEDASSDDEPPRPAKPKFNAFDLLNAGDDDNDEEAESEEDTQESVIQQPEPEPAPAEPKSASKKKKKKKKAKAAVVTEPDNGSDDELDEIDRALKDLATDGQLPAVGAATTNNIQDASFPKTTDELLAVDPKFLNATNEMKRLFGNVVLENFDQPADAGTGRRRDRNRETVDLGRALTGRYSPASRGQSLAGVTLRRNILMQGKDEWPRAPSGGLGMELEEKFASGVTLYRIVHNAGYQDVQRQFELCVESMDPQRLIHHLQYNPYHISTLLQVSEIAKHQSDHAVSADLLERALFNIGRSAHSSFNTRLREGQARLDFLQMENRELWLVGWRYIANLGMKGTWRTAYEWAKLLLSLNDSDPYCMKLLIDHLALRGREYTQFVDLCTQTRFSRDWADLPNIQCSLVMAYLRLNKPQECRRQLHHAMSRYPWVFNRLAQELDLQHIPKQIWGKMPPTGSHELLTELYISRAKDLWNTPEAVSLIVEVADTLSDDKAAVEPPEITLDIARHVVLSDIPKVTTHLPTRFVSGRMSASDPLPPYESEAFRQQADPTPSYLARVPEAGRPQWLRDLLGQMQNGGGIRFPGLQGGDDGEDADAAPQDEAENAPSGGRVRALDGDQQVLESWILQDGLESLQMFLHEYGVDRGNWGDVVDYGPLTDYLEALGEIQPEASRQRLLHGPIQEVIGEFAVTMLEDELEMMEEEALSEHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Z3</accession>
    <name>A0A1Q5T0Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Z3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012569921" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="52" mass="6076" checksum="24EE43D6CE1102B5" modified="2017-04-12" version="1">MSFFLVCLAKSYIVIMSWFLQKIVHNEAMRTDPKEIYGWRVYALACSVSVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1C3</accession>
    <name>A0A1Q5T1C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1C3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1C3"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="22535" checksum="8F3C444E672F913C" modified="2017-04-12" version="1">MGISTSSIHYPRDSEDGFEALRILQKKLPAELALQILDCAQYWVLSQVSMERAISYQEHDCRDRAPYLVSDPIQGGRSPVREIRIDIWSHDQGWSSYTEDHGTYRNSWTWFEMGIIRAPGTEGVSEDFNIRLATNMHASRVTQNHQKVYRADDDLPWMRSLQAGDRISIIPRALYPGWQNFVEKAFIEIYTDPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1M1</accession>
    <name>A0A1Q5T1M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1M1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="6182" checksum="AA296625390D025C" modified="2017-04-12" version="1">MPITGWSDEVDRTVCYGMQQAWHDYRDDHALGKPPLTRGINRANKTIELLQPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2W0</accession>
    <name>A0A1Q5T2W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2W0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2W0"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="373" mass="42108" checksum="D39BC36A02350886" modified="2017-04-12" version="1">MEDLGLIFWKQWRSKEAEIIHAQVFENRKKILGLRHHDTLMSMSNLTVVILDQGRFKEAEELSIQVVGLQKDVLGAEHPDTLTSITNLASSLYDQGRWKETEELEIQVLELEKSILGVEHPDTLISMANLAATFWKQGRWKETEELEVQVLETQKNVLGVEHPSTLGTMVSTFRSRGRYQEAEQLGIVVLNLKKKVLGEGHPKTLISLEHLGLTFGNQGRWKEAEALEVPLLESSKAILGVEHPLTLKRMQNLARTWKSQDRLKDAVAMLKQCGKLRTSCLGEDHPDTAETLSELSSWKQELSDHSLLRTCSLEVNKSSSEGEPSHNDCYFPTRNVSHLFKLSNPLVGFHPILSSLKASNIATNRGQDDDDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4B7</accession>
    <name>A0A1Q5T4B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11311</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4B7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4B7"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="142"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="252"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="37155" checksum="C80C286FA2AE799B" modified="2017-04-12" version="1">MMQSPKIHGRPAEDSAPLKTSYATTKKSHDPWVHLLAGATGGFATAIATSPLDVLRTRLQSDFYQRPSPTSATSAAASAISKHTSHKTTRIISNIYQAEGWRAFFRGLGPSLAGVVPATAIKFYVYGNCKRIGAQLLGTGEDSTLVHAQAAICAGIATATATNPIWLVKTRLQLDKAQTTTGTRRYKNSLDCVRQVLRQEGISGLYKGLSASYLGSLETALHLVLYERIKTILHTSLGSPDGKDTATQKEITSWLSTTGAAGSAKFAAALIAYPHEVIRTRLRQAPMENGVPKYTGLAQCFRLIAKEEGMAGLYGGLMPHMVRSIPSAIITLGVYEFVLRFIGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4R4</accession>
    <name>A0A1Q5T4R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division control protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4R4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4R4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="87"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="52691" checksum="646BBB60427839C6" modified="2017-04-12" version="1">MDSLASPIANGSPVASRDSPTPSGKESPFVERTNPMGSGNAQTVSSRDPKAVAQAANDMKNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPKERTGPNADIIPKTVSIQSTSADIEENGVRLRLSVIDTPGFGDFVNNDDSWRPIVENIEQRFDTYLEAENKVNRSNIVDNRIHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEVALFKQRILADIQHHSIQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANSEVTAADGRRVRGRSYPWGVIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNFLYENYRSDKLTQMGVAQDPSVFKEVNPAVKQEEERTLHEQKLAKMEAEMKMVFQQKVSEKESKLKQSEDELYARHREMKEQLDRQRQELEEKKARLESGRPIEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5P9</accession>
    <name>A0A1Q5T5P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein mrp21, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5P9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5P9"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO95542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24273" checksum="8C04412EBAD4A8CF" modified="2017-04-12" version="1">MDTRILARGLRASPTTAWLLSSRQQQQPIILNTLRYNSTTSSPQTPPSSSEPTQTNTSVSSDTPKPAPTKTVASDFDEILNKLDLGNRSTLNSKGEPRRVFSDAVSRSVGGVGSQTFKDRAAQQLASRKLELKLGPTLGRQVHVEPERGVDLPAAIRQLEITCSVNKIKANAHEQKFYKRKGAVRKELRRTRWRKLFRFSFQETVKKIQRMQAQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5T8</accession>
    <name>A0A1Q5T5T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5T8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042617932" evidence="1">
        <location>
            <begin position="32"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="233" mass="25670" checksum="D768D097C7A656F4" modified="2017-04-12" version="1">MAVLLEGRKALHWLNSILISLMVSMLGLLETGTPISCFPSYGTGNMQSSSKGYDTCLGPKQLEALKAIYAGPMDKRTNTTVYPGFSLGSERELLAQETLLYKAYAAPLLQNLIFHNLSYDIDTFSFERDVAQVDAIAGPLIDEIGVDLGAFQRRGGKMVVTQETDIESGRQDHEALPNGLHADQASDENVCGDANYSSEASFAFEEMLGCLKDLRGRYEIPDKFIEMLRRAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5U5</accession>
    <name>A0A1Q5T5U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5U5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5U5"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="36433" checksum="F3E41155AF830788" modified="2017-04-12" version="1">MARIFLTGATGLIGGDVLHVLKTTHPDYRISALVRDSTKAATVSKAYPDVRIVLGDLDSASLIEEEASQADVVVHAAANKHINSVQAIVRGLAKHTGPKPGYLIQVSGASLLSIPDIVNKTFGEGSRKIYGDIDDADEIRDIIRKNADKRVVDSFLINVTGTKTAIIFPPIIYGQGRGPINQRSIQVPEISRVAIEKRQTFQVGKGESTWSNIHISDLSNIFVKLMEKAVEGAEGDLWNQNGLYFVGGGPQLSFRKISQLVAESTHNLGLTDSVTVESITPSEADGLSPAASVFWGTNARQSPQRALQLLGWTPRAHSLEQEIPTTVRLEATRLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6J9</accession>
    <name>A0A1Q5T6J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein yippee-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6J9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6J9"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="243" mass="26041" checksum="28B16C1EC738CECF" modified="2017-04-12" version="1">MSKDQSRRSLSFPKFLIPSFPTKHTTTTSTTHSPPPINSTSNGSKYLTGHLSYLHCTTCAAHLCLTSQIISKGFTGRHGRAYLVSAEPVASAVSVSASSSPTVSLPNTILQHPVPRQLVTGAHTVSDVSCAFCGTVLGWKYVAAEEESQRYKVGKFILETKKITASSCWEALEDEHGDGDGDRAVGGGGSGSGDESEDKAEFDSQDEDECEDLFAGIWSPGLASRRRSRKIERRPATAIFGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6P2</accession>
    <name>A0A1Q5T6P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6P2"/>
    <dbReference type="OrthoDB" id="4241662at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="39319" checksum="2AD9AAB80D714400" modified="2017-04-12" version="1">MPTPLQPPDHPLALRRTHLLAPAPDRLTNTPTTLTITRNNTLSGRAFSVHHLRTHEPYDSPTRRSLLYTVSGRFWSGTQAREIRDAAGRPLLELRRMWWQRAWSVKRAGGGGDELMGAEMRWGAGVKMKMAVRVRNALLVGAGRRSEADDEFLRSEYYPMHSGRGGRRQQHQNHHQQYRRWASPPPPYTAIASSSTNPGPGPGPGSIRRRRSTDTVSSKSTHLPSYASAHRRSTHSLRELLDAVEPPAEPAPASSYAYAFPPPRRYSEAVVEERAELRVVQMSNTVAAVMMGEKKIVSIRREKVMMNSQLSGPMDRWEVGVAEGVDLLLAVSIVLIMAEFVRHEYRVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T7Z5</accession>
    <name>A0A1Q5T7Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T7Z5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="91" mass="9861" checksum="FD195B56ED45CC0C" modified="2017-04-12" version="1">MNSETPYGLCKSRSNSNSRSSSSSRQQTTADEFGGETQKAAETDESNSAESEQPASEDGDTLTPPVCNAEICHFRRRRSPSSAPSSQCQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T837</accession>
    <name>A0A1Q5T837_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T837"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T837"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="268" mass="28500" checksum="D62A711D45567BF3" modified="2017-04-12" version="1">MAIPSTQTAAAIPPPGPTGSLNIQISKTHPIPKPTDGEVLVKLEFSGVCHSDVHSIRGDTPMLTDVAGHEGVGKVVADGYTALAWSARSVLSTIPHVPIKRMLERGVQIAAKKGLKVLAIDKGEKKRKLCLELGATEFLDFTEIDIVEAVKASTSGFGAHAVICTANGEKAYEQSMQMLRRLGTLVCVGIPNVPFKLPVTPLDMIVQGLTIVGNSAGSATEMDELMEMAVAGDIKACIEVFDLADILDVLKRLENSEIEGRVVLKIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T846</accession>
    <name>A0A1Q5T846_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T846"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T846"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="260" mass="28468" checksum="A705EC35A2D58408" modified="2017-04-12" version="1">MALSARQLSCTTGYDAFVSAQYYQECLETLIPALNDQEVTMDNDLLAATVILRLLEEFDGQYPSPHSFIRTSVLTAIAAPLAGSDLRGHSFGTRAFIKGPPPSMTTTPSLRQAVYWSGLRQEIYNALSLQQAPDVDLSSLHSLFTALGPNDGDCLWANQAIAHCADVLLFSFGTGARSTGVHADLQEQNQHWIDSRPPSFDPYFIGSDEVEVGTTFPDIRFSSPWHGSNSEECLDNVRSGIVKQLRTPSNGHRLYGPPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9G7</accession>
    <name>A0A1Q5T9G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10443</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9G7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9G7"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010199400" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="78"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO96889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="42657" checksum="7E24FB408A2E290D" modified="2017-04-12" version="1">MKRVLLAKFLLWTGFAASYAVGSTESIDRRAVQDSNQKTAIPSRDGLRFVIDGHADYFAGSNSYWIPFLKSNSDVDMVMSHLKQSGLKVLRVWGFNDVNEIPTDGRVWFHHIQNGASVINEGADGLQRLDYVVKSAEAHNVKLIVNFVNNWGDYGGIAAYNTAFGGNATSWYTDKASQKSYRDYIKAVISRYKGSSAIFAWELANEPRCRGCDTSVIYNWAKSTSAFIKSLEPARMVCIGDEGMGLTTQSDGSYPFTYYEGVDFEKNLQIPTIDFGTLHLYPSQWSEQDPWGNLWIKAHGAACVKAGKPCLLEEYGSLALAASEASWQQTALKSKGIAGDTFWQYGDNLSSGPSPNDGYTVYRGTANYTILVTDHVKDVKKLNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9K7</accession>
    <name>A0A1Q5T9K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein GAL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9K7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="209" mass="24153" checksum="CFF79345D43EAD39" modified="2017-04-12" version="1">MTNSPSQLVNLAVTTTLERLVAAYFGWYNPSYPILHEKTFRDKFLNRHQVHPRSNWHIIFHLVFAIGHWILGEESEAEQSRSYMAARSCMSMRMLESGTLLTVQACLLMGNYLQKRDRPNTGYNFIGIAHRMALGLGLHREPPIGTMEDTLSNERRRVLWWIVYCFDSGFSITTGRPITVSGSFIETRLPRNIDDSVRRTDCLQHSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAL0</accession>
    <name>A0A1Q5TAL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_10022</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAL0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAL0"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="486"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO97228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="619" mass="69058" checksum="9E8DCFCDCF708604" modified="2017-04-12" version="1">MTSRKTQQEIDKTFKKVAEGIQTFESIHEKVKAATNPTQRDKLEENLKREIKKLQRFRDQIKSWAAGNEVKDKAPLLEQRKAIETCMEQFKAVEKEMKTKAYSKEGLSAASRLDPKEKEKVEACDFLSTMVDELQQRIEAMEAEEEALQAQMKKGKKDTNKANRMADISRVTERHKWHVNKLEFLNRSLQNGNLEVNQVLDLKESIKYYVDEGHNVDYSGEDETLYDDLDIGEEVEAQFGMGAENDRVSSQDAQSIQDDEPEPKPKPSKVDATSHRRPSTQMKSPLPVLATLHPSASSSALPGMKPAPLPTRLPGETLKYASAAAAAAASDKSGVGILPLPPPPGASPAFSNVLPVSKASSTASPVVSSVQPVARPTTTAGPSAPPAVSASSSEEAVPLAVRSKTAVGAAASSSSSPAPAPTPKAETVKEKPTTNGKTTPKEAAEGDESIFHLPPGLQDLIQSFEVTKDRATANPTPAVQRLLATSLTTCPEPGDAEKPRHYKPQNPYNTPLYYPQEPLSIFDDPRLYDTGRIDTDTLFYLFYYRQGSYQQYLSAKALKNQSWRFHKQYQTWFQRHEEPKNITEEFEQGTYRFFDYESTWMNRRKADFKFVYKYLEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC63</accession>
    <name>A0A1Q5TC63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9696</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO97770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="42854" checksum="4886F113853B4A19" modified="2017-04-12" version="1">MDGRKKNKPSLSRLATRLTNDDREQTGLADRSIPPLQTGLTNRSIVPEIQAKYYTDRDSTMATEIPAEINIHQLSKSEKQAIAPFLFPEDDKDDENVAPIKHDVQESKPAYVSYKTFDEESPTTTKRKTMYYEDAFAVRGSHNSPKERVARDSVVVVELTTNLKACCPIQTHLFVVKQTEEATYEEVKKASDLASCLRQFYQRPEWAVQVVVQHDADILFDGPGPSYLLKIHALPSAFAPVTNMRNTGLIQKTIHELYGIDPKDGVVLFLPVPEENLATNGSTAQGAIARLESSEMDSPGLIKSISRSMSRRLKSNSGTSAPMSLPSTVVSPTLSTPTDPIHSPIGDAALSEEEEAGPSLKKRESLRTIIHRHMRPKKGSGMKEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD82</accession>
    <name>A0A1Q5TD82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD82"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000013">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="7">
        <location>
            <begin position="155"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="481" mass="52981" checksum="61AE05874946AACB" modified="2017-04-12" version="1">MKAARAARMPRAQGTTTRATTRLVSGTSNAKSSVAASTLLHPLSPSSTASLPRKALSAPLSKLPLSSVLRSLLILSVSSSPLLLKPCIFALSRLAHPRSALWDVSKNPLLNMLVKHTIYKQFNAGENKAEVQRSIENIKSLGCRGVLLGYAREVLVGENQETTRDEKAALAEIQMWLDGTLRTVDMAQEGDFVALKFTGMGTDALSLLQKQAAPTEFMDASIQKVCDLAISRRVRLLVDAEEQAVQPGIEAWIMKYQKYCNSQTPGRAIFYGTYQAYLRSTGETLARHLETARQEGYTLGVKLVRGAYMKTEPRQLIWAEKEDTDRCYDGVVEALLTRKYNSMLQRPSKDTPVELPPVNVIIATHNRESVRKAHAIRVQQAAKGEDYGVDLSYAQLQGMADEVSLELLQGFESAEADVGMTPASAPNVFKLLTWGSVQECMGFLLRRAVENTEAVGRTKDSQIAMIDELKRRCRNIFGGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDF8</accession>
    <name>A0A1Q5TDF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDF8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="348" mass="38643" checksum="96E77EDA0A80034D" modified="2017-04-12" version="1">MVVVKLPSIAIKYPLNIMQMRRVQIKFSQDRDYYTVLSMLSAANCPLAEGSIPTFHRPPSTVSWASVSTAQLTKNPPRDAGAAITPESNAPVPSNYMGRKAYGFETASNAPQGRFTMQTLERENETALGRTLPAIPAEGGQATSEKAPARHTTGPIYHDQELNQMLPPKRDLPFTKLKSKMSRAGTTSLKSSQQIVPESSYPEPDNLKRRESFMSESQSQQLIQTQPYPETMNLSQDPARVQATLPYPSVSTESQQQGRVSSVAGTSQRARTDDGHVSETIIQAPQSARWSVPISVEEQLSEYVKAPTKERSAFLEKWMCELIQDDNFVSLCEDVEGTWRRFAFGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDH0</accession>
    <name>A0A1Q5TDH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDH0"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="16249" checksum="895011951A79F302" modified="2017-04-12" version="1">MSSLPSPVPIILCGRRVEIGKVVSELLAPEFEGIHFITTNEAALTDIPRLLKGEKLASPDTSGVGTQNYSQVPRAVIFGRGYEVAEVEEFRKASEGYANPVVWFTGDPNKKPGPNDPPPGPGYAQAAASALKEKLIAWRDEGGVDDGIFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDK8</accession>
    <name>A0A1Q5TDK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maleylacetoacetate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDK8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDK8"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="224" mass="24714" checksum="C0E7F9527A09B34C" modified="2017-04-12" version="1">MPDQVTLYTYFRSSCSARLRIALHLKNIPFTPIFINLLRDEQSSPTHLKVNPSGTVPALIITRESNPTSVTITQSLAALEYLDEAFPQGPPLLPTSPERRALVRTLSQIIACDIQPVTNLRILKRVAPLGADRAVWSRELIEDGLRAYEAIVAGCAGKYSVGDEITMADVCLVPAAWGAERVGVDLSAFPVVDGIVRNLESVEAVRMGHWQRQEDTPEDLRVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDZ5</accession>
    <name>A0A1Q5TDZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDZ5"/>
    <dbReference type="OrthoDB" id="4356380at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010361958" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="8793" checksum="B2A9582A1B042FAE" modified="2017-04-12" version="1">MFVKSILATLGLAALALAGSGAAKCSSNQQVVCKDNGNGGVLTLGNVLPGALGVDCSGGDVYCCDKGAVEDVGLVNLDINAQCSLNHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE23</accession>
    <name>A0A1Q5TE23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sterigmatocystin biosynthesis regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE23"/>
    <dbReference type="OrthoDB" id="4339209at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="447" mass="49017" checksum="37DA657CF7731140" modified="2017-04-12" version="1">MAFPAQQQRVEIIRASCDNCAKSKVRCSKDQPSCQRCLYQGVPCIYSPSQRSRKRPPPTPPPGTAPHSQGVASTRDRNGSILDACQGSQRRDDEVVNEGQIMADIRTVDMTSPDPLPVQIDTPFSERTQFPADALSPIKWSELLESFDSSTPTPNDLPGIPGIPQMPMASPQSRMDTSTSNGNGLDEFPWLLPSDSHKQSLWSLPAQHQSVHQCSQLAMSAISRLDAPMNPCPTLSRSNCPDRRIQTITNGSGARSFDDILKDSHSSLEDVLAILECPCSIKTDLIFLVTTTCTRVLSWYQASLDRSAGCLPREPDNSSGYSESSNDSGSRSRSRSSPGAPSSLRSTPESNILQGLSESFREWVSIPSINVGAYTLEPAQSRRMIAQLILAEIDKVKEVLAAFSRRYCRQKGMYGGDDNEKGLHLALEAHLRHQMKSVALTARELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF30</accession>
    <name>A0A1Q5TF30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF30"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="7110" checksum="456D8FA14EEA0A3D" modified="2017-04-12" version="1">MSRDYERQEALRMTNQSPSAGATSNTGDGSSRQPPEPYINEIIPVDPNRARRRPVEQNPRSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFH6</accession>
    <name>A0A1Q5TFH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFH6"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="505" mass="56161" checksum="D437ECB63CC9E6FD" modified="2017-04-12" version="1">MPDSTDTSLGGKPTDDQFEDARIYDEKHPDRESAAASPPSFAGVDEAAVLRKMDIRLIPMLSALYLLAFLDRGNIGNAKIEGLLDDLHMTGPQYNWTLTVFFFTYCVFELPSNLLLKKLRPSRWLPLIMVAWGIVMTLMGIVQNYGGLLATRLCLGIAEAGLYPGVAYYITLWYPRHRAQFRQAMFFSAASIAGAFSGLLAFGIAKMDGVGGLAGWRWIFILEGILTVVVAFVAPFAIHDSPETATFLTEQERAFVIHALRIQNSADAREMVQDESKFHMKYVIDAFKDWQIWLGLLMYWGITCPLYGISFFLPSIIKDLGYKSSTAQLLTVPIYITAAIVAVAAAWYSDRRKQRSPFILFFMSLIAIGFIIVIASTGRGVPGVVYFGVFIAVIGIYPAFPGNVTWLSVNLAGDYKRAAGMAIHIGIGNLAGAMSSNFYRSKDAPKYILGHSLELGFVIMGMIAVLLLRFNYQRINKKRDQLDPSEYPSDPDSLGDRSPLFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG72</accession>
    <name>A0A1Q5TG72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signaling mucin MSB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG72"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG72"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841061" evidence="3">
        <location>
            <begin position="23"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="696" mass="70169" checksum="B7303BA5D67DBE9B" modified="2017-04-12" version="1">MRANTLSLLAAFAIGGFELVTAEHVEHPRYQARDVKRVVRNSTLATRSTDNSWSAIWASIADSLTEQPSTSITPTPIPTSTDAGKQVIVVISSDAEGHVHTLTTSTEIVSAAQPTATTSTAVQSNTAKATSSDPLLNQVGSDVSNLLGLGSSTTTSATSAATGSSSNANSNANSPAAKTATSDAATTTSDSLLDSVGSGLSSLLGATATNSSSTASPTDKDSKISSTALATTTSSQGSLLESLGIIIPAAETTTTPTGSSTIPVSVPAVSPTSSPTSSSTDDLLGSVIGGLTSGLGSILPSPTQTSTGTGIGLIPTPGVPASSGVPHPSIPLTVSGTAAPTTATSVGIIPTPQSSGTGSGVPTPTGNQDTTKVPTSSVALPTTTIEPTTTAEPATTKAPEESNTNTNNWIPSSILVLPTSSPSQTTSTGTNSNSNAAPTTLPGSITPSNGVSEAPSDSVLLQLGFDGHLPWTFVATTPLSSSQIFEYIPKALKNALPQTASTMWALEPYYSWQTTGYNATLAIFYFPRDKVQALKDLKLNPNSALYQSSDESVKTLMSMVDPSIPLEFSGNYPTSSGSSASNAGSGSSNNGGSTDSSSNTDGSGNSSKAKASSVGIGVGVVAGAAAYGAGMFWVARRYRKRKQLHKRSSSTAEQMSQVSGGSMFATGGRMSGSQRTGRSGQMISAPVMAENSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGT3</accession>
    <name>A0A1Q5TGT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WW domain-containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000657">
        <property type="protein sequence ID" value="OKO99448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGT3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGT3"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="38140" checksum="6CC6F4C9B9A4D82A" modified="2017-04-12" version="1">MPFYNTYPGFLYRQFLVCPPKAPSTTSLHGKAGLVTGSNTGLGYQASAQFLALGLSHLILAVRNTSKGEAARKSLLASLPASAKPPPLVEVWELDLGSYASVTAFVERLQQSDLQIDFALLNAGVANFHYIVNESTSHETSMQINWLSTALLTLQLLPILDRQAAQYPGQTRPVISIVSSETAAWAQFKEAQISVKENIPLLDVLDDKEHFDMADRYYTSKLLYQLFFLELFKRRSTSKRSTGAILNLVNPGFCYGSELHRTAEGVFGKVLGGMKRVIGRSTSMGARTLVHSSVLAGDESNGRYLSDCKSAPFAGYGDSDAGRITQGRVWDLTLAELSSVMDIEVLSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGX0</accession>
    <name>A0A1Q5TGX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PENSUB_8433</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000657">
        <property type="protein sequence ID" value="OKO99449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TGX0"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 26" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="27">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="28">
        <location>
            <begin position="1095"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1744"/>
            <end position="1746"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1744"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1745"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1770"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1780"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1789"/>
            <end position="1805"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1813"/>
            <end position="1816"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <begin position="1843"/>
            <end position="1845"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1844"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1845"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="26">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OKO99449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1858" mass="204019" checksum="603C986010D50B7F" modified="2017-04-12" version="1">MRPEIEQELAHTLLVELLAYQFASPVRWIETQDVILAEQRTERIVEIGPADTLGGMARRTLASKYEAYDAATSVQRQILCYNKDAKEIYYDVDPVEDEPEAAAEAPAAAAGASAPAAAAPAAAAAPPPPSAGPAAAVEDAPVTAVDILRSLVAQKLKKGLSDVPLTKAIKDLVGGKSTLQNEILGDLGKEFGSTPEKPEDTPLDELGASMQATFNGQLGKQSSSLIARMVSSKMPGGFNITAVRKYLETRWGLGAGRQDGVLLLAITMEPASRLGSESDAKAFLDDVTNKYAASAGVNLSAPTAGGDSGAGGGGMMMDPAAIDALTKDQRALFKQQLEVIARYLKMDLRAGDKAFITSQETQKALQAQLDLWSAEHGDFYASGIEPSFDPLKARVYDSSWNWARQDALSMYYDIIFGRLQVIDREIVSQCIRIMNRSNPLLLDFMQYHIDNCPTERGETYQLAKELGQQLIDNCKEVMDVAPVYKDVAVPTGPQTTVDARGNISFKEVPRASARKLEHYVKQMAEGGPISEYSNRNKVQNDLKNVYKLIRKQHHLSKASQLQFDALYKDVLHALSMNENQIMPQENGTAKKSGRNGVKHSAAIRPGKVETIPFLHLKKKSEHGWDYNKKLTGIYLNVLESAAQSGLSFQGKNVLMTGAGAGSIGAEVLQGLISGGAKVVVTTSRFSREVTEYYQAMYARFGARGSQLVVVPFNQGSKQDVEALVEYIYDTKNGLGWDLDFVVPFAAIPENGREIDTIDSKSELAHRIMLTNLLRMLGSIKTQKQAHGFETRPAQVILPLSPNHGTFGNDGLYSESKLGLETLFNRWYSESWANYLTICGAVIGWTRGTGLMSGNNMVADGVEKLGVRTFSQQEMAFNLLGLMSPAVVNLCQLDPVWADLNGGLQFIPDLKDLMTRLRTEIMETSDVRQAVIKETAIENKVVNGEGSDALYKKVVAEPRANIKFDFPKLPDWDNEVKPLNENLKGMVNLDKVVVVTGFAEVGPWGNSRTRWEMEAYGKFSLEGCVEMAWIMGLIKHHNGPLKGKAYSGWVDAKTGDPIDDKDVKPKYEKFILEHTGIRLIEPELFKGYDPKKKQLLQEIVIQEDLEPFEASKETAEEFKREHGDKVEIFEIPESGEYTIRLRKGANLLIPKALSFDRLVAGQIPTGWDAKRYGIPDDIIEQVDPVTLFVLVCTVESLLSAGITDPYEFYKYVHLSEVGNCIGSGIGGTHALRGMYKDRYLDKPLQKDILQESFINTMSAWVNMLLLSSTGPIKTPVGACATAVESVDIGYETIVEGKARVCFVGGFDDFQEEGSYEFANMKATSNAEDEFAHGRTPREMSRPTTTTRAGFMESQGCGMQLIMSAQLALDMGVPIHGIIALTTTATDKIGRSVPAPGQGVLTTARENPGKFPSPLLDIKYRRRQLDLRKKQIKEWQESELLYLQEEVDAMKAQSDESFNASEYMHERASHIEREAVRQERDAQFSLGNNFWKQDSRIAPLRGALATWGLTVDDIAVASFHGTSTVANDKNESDVICQQMKHLGRKKGNAVMGIFQKYLTGHPKGAAGAWMFNGCLQVLDTGLVPGNRNADNVDKVMEKFDYIVYPSRSIQTDGIKAFSVTSFGFGQKGAQVIGIHPKYLYAALDQAQYQAYKNKVESRQKKAYRYFHNGLINNSIFVAKNKAPYEDAQQSQVFLNPDYRVTLDKKTSELKYSTTPPKEVEKQSTRQMVESLAKANAAGENSKVGVDVENIDAVNISNETFVERNFTASEQEYCRKAASPQASFAGRWSAKEAVFKSLGVSSKGAGAALKEIEIGSDANGAPVVNLHGAAATAAKEAGVKQITVSISHSESQAVAVAVSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH75</accession>
    <name>A0A1Q5TH75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH75"/>
    <dbReference type="OrthoDB" id="4892971at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11508" checksum="D9FE81A7A48A23B5" modified="2017-04-12" version="1">MSSQQVVLQVIYPPSAASSFNMDYYLNSHIPMVKKRWGPQGLQSCIVTTGAKDAGYYVQTTLVWENMTSLENVKDADVVREDVKNFTDIPPYRWVGIVAYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THD8</accession>
    <name>A0A1Q5THD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THD8"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012863733" evidence="2">
        <location>
            <begin position="17"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="204" mass="20076" checksum="27FD9A9FF0007865" modified="2017-04-12" version="1">MKLTSIVLALAASALAIEPQPQRRDTATAAAATTNPTDTSGFNFGEISSALANLPMNTTATANFGNISPPPRSLIPEILSVVPVTVLWELINPQSRSSLASAFSAGSTPAWYSSLPADVKSYMSVVKSQISGGALTATTGLAYESTTTKTGSSATGTGTGTGGSTGGSAGATSTSKGLAVAAQPTGLTASVIGALGVLGLALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM42</accession>
    <name>A0A1Q5TM42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAB1-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM42"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="262"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="931"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1087" mass="116063" checksum="D612C0C8E4EE3C57" modified="2017-04-12" version="1">MASTLNSVPAGNSAAGNAVNSSAQNSGRPSLRSSANSKGDGRRQSGSPVDGGQRRTNSHKAWTQGTNPITQRSSYASPNGNVTRQTGSPRPGQKESNTPDSHAHDRLVFLFASFIGLNTTITTKSGEKFTGIFSSSSLEASDSSFLLKMVQRISQENQGKTNGVSDTTTPYVGSAPEHGMAFDIKDVADIFVPKVVPAEVTVKESNGGAGFRTDADISGNLAMRERTLKRWEPAEHEVDMSLESAAGDSKGWDQFETNERLFGAKTSYDEHIYTTRIDRSDPTYRQKQVEAARIAAEIEGTDVDNAHMREERGLVAPDTGDQDEEDKYSGVQRENKVFPPLVSGQPNKYTPPGRRQAGAQPNVPAKQASTTPAAAAAQANEVPPAEKQQPVPAPKAASEIQQKVESIKPAPTALTAPVAKPQRTIPENATANVETEVLDHFRQFANSEKLKMQERRRNQASYDRTVKLNELMKFSKNFKLSTPVPKDLVPILAKDPHKQEAIISRVHQSDDKPSPKAAAQVPEQKAPVRPAGPTGTTSPVAPSDRQNYPRGRQGYLPTGPLAGPGGRYPQQPMQAGRPGTGMLSHRLADNLQQRKGAGMGPVPAPLPIQDARGPPPTGPASEQPRVTSPIKSQTPTTAAASKFNVRAMEFKPNPAASTFTPGGAAPAPPTAPAAAASAVSAASPSSFSRNRSVSRATTPSAFFGIRKPQSASERPSIDDQFNPIKRMKKESAEVAENKPYPSTGGIPPPYKTAPTWDVPQGNEEKNFEAMFKQPGGVPSVSPQGRSVSSNPNLPQQHQLPFHFQQGNPGMPPSSGPPNGPHVHQGPHGPGPHMEDHHRMQLSASSSQVFPSPRMSQSHVGYPSPMAPHAQLAFGQPMPQFYGGPQPGHMRHYQNGPQFSGPQGNMGAPMMVQNPSNGPYMGVPQGMSPYTPQMQMYSPSPGHAYPQHAPPPQPHSGYPSPSRGAPMMMHQNSQSGQPPQPMMFMSPGQPGQPGFGTQPGHSESPHSVGIAFVAHSPPRLVPTGRGGYPQQQPHFSSSPHQAHHFPPNHRTPSNGYNQTPQMPPQMSTNAPANAGAGSHAAEPSDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM99</accession>
    <name>A0A1Q5TM99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM99"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:linear primary-alkylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.30:FF:000001">
        <property type="entry name" value="Alkyl/aryl-sulfatase BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="entry name" value="Alkyl sulfatase, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.30">
        <property type="entry name" value="Metallo-beta-lactamase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052195">
        <property type="entry name" value="Bact_Alkyl/Aryl-Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223">
        <property type="entry name" value="ALKYL/ARYL-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223:SF1">
        <property type="entry name" value="ALKYL_ARYL-SULFATASE BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="88"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP01322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="610" mass="67692" checksum="0B133FE57451B8D4" modified="2017-04-12" version="1">MATQQFQPSFADTTDFENAKRGFIGALDPCIIRSADGRVVWNNDEYNFLAEECPPTANSKLWRQGQLLSIQGLFKSTNGIYQVRGLDLSNMTIVEGKEGVIVIDPLTSVETAAAALALYRKHRGDRKVTAVIYSHSHIDHFGGAQGILPVAKSHSIPLIAPEGFMEEATSENLYLGNAMRRRAGYMYGNRLPKGPAGQIGCGLGMCVPSGVNSLVPPNTIIYKTGEERVVDGVRIVFQMVPESEAPSEMNFYFPDHRALYIAECAVHSLHNIITLRGAQVRDAKAWSQYLDESLVLFGKESDVMLAGHAWPTWGHEDIAKFIGDQRDLYAYIHDQTVRLMNHGMTGIEIAEHLSLPPSLQKSWFAQGFYGSVSHNVKGIYQRYLGWFDGNPAHLWEHPPKQSAKRYVECMGGIEEVVQKAKSFAEDGDMRFAATLLDHAVTFDPSHTGAKTALASVFTKLGHGSENGTWRNFYLTGALALLAGNRPDPRQSMSTGLRPEQSVEQWLTLLSIRLDGIKAAEECFSIHFHLTDDQRWWRVNISNGALTYREADSNEGIHGEANLTVHLTRLELLQVLSRGNLEGTSYEGDVDLINKLLSLMEGSEKPGQMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ30</accession>
    <name>A0A1Q5TQ30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ30"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="917"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115515" checksum="BDD8C7B3BCDECA6A" modified="2017-04-12" version="1">MDHISTLCALSTVGIATSGLALGRVERSKSSIFRRKTFSYNQPPATPSEQSTPVNARPKTSRLVRPTTAGPDWTHFSEKAIEGQDGPAQDPLQGPDLRRVSMSFGAARRRRRGQTLSSPPLRIPEDEPAESLTSQESHSRRPSTSWMRRLSMASFQTESPSTNSPVTPSFNGSASPILPRPTSSRRAPNKLVKRTSSQHSNANPLFVNTTVSPASALRRPATSHQRSESMRLQSPLPMDFGSRFSGNYSMESPTAEEFETHLQTDWIPYLLPKSEGFSERLARRISTTASPKPPGVRRIIPEQDTLPALVLATTLTSRTSLPRDDQSVPATPVMFRNPFQTEPTTSVASAAPPPSSTHVPQAPESPALISPQQPEKSAHKHSFSFDVEPKKIIVNTVTASGTPIPGRARAGSLKRVKGRTFSIPRAELAKLHSVIPSPPQAPQRRNITDPSVFRRPFALSPPGLAVSTFGRDHPMAPRSVSQDYTIGMRGQRALTSDAVALSAWQHSGRPDSYTFSSLRRQPKRHSIAASDPSSTVIGSDDTRVFTSGDEYETDMMTDYWDSVRTRETSGGGLKGLQIETMFDKAGSRLSNEEVTTLEDLLPRGSFTSRLEQETPLFPDSLVSSVAQVRLNEDTWISEGDEENASMIGALPGEPNGAAVQSPLSGSLSRTSVAHAAFSSAIPEPGSPVAESHMSQKMNIFDWSEQARPDRDATDTEARPRTMHGKQSGVARGSRAACRKVPSAIHLRSQSVPVARELPANETRQPSGKFGTWGLGSKGVSEDWDSDFDFDDSEEPAASNDTKSSEPEAAPQSMMVPKAILERQASLRGQFGQVQELTLLVQELKRLRHQASVLDLVTGPSSELWKEAEGIVNLATIDDDDDRRSPPGSPSSLTFSFDDSDDEGVNSASKRNSDNSWQGGPQQGIQIQSTSPKQPKENHPSSSWNSNTQSENRLFTSPLGHLSKNSPKSKSVLDILQPSRRTEDSSLAPPPRTQKLPFDTQSLRDLVVRAGVVTRALKEVIRKAEGVDSSPQNVFPSDPPFRRIFDQPSHDDLASFEAAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQH1</accession>
    <name>A0A1Q5TQH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQH1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQH1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP02475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="496" mass="53897" checksum="0BE8DD879A6900A3" modified="2017-04-12" version="1">MSLSTTIKTPNVTYEQPLGLFINNEFVKGVEGKTFETINPTDEKVITAVHEATEQDVDIAVKAARTAFEGDWHNVTPSNRGRMLTKLADLFERDIEILASIEALDNGKTVTMAKGDVGAAAGCLRYYGGWADKITGQTIDTNTETLTYTRHEPVGVCGQIIPWNFPILMWAWKIGPAIAAGNTVIIKTAEQTPLSGLYAAKLIVEAGFPPGVINVISGFGRTAGAAISSHMDIDKVAFTGSTLVGRMILQAAAKSNLKKVTLELGGKSPNIVFDDADIDNAISWSNFGIFFNHGQCCCAGSRLLVQEGIYDKFIQRFKERAAKNQLGNPFHENTFQGPQVSQLQFDRIMEYIDHGKKEGATVAVGGERHGTEGYFIQPTVFTDVTPDMKIAQEEIFGPVVAVTKFKDEAEAIKIGNSTSYGLAAAVHTKNVNTAIRVSNALKAGTVWINNYNMISYQAPFGGFKESGLGRELGSYALENYTQVKTVHYRLGDALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRI9</accession>
    <name>A0A1Q5TRI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRI9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRI9"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47326" checksum="59A59B590505A24E" modified="2017-04-12" version="1">MASPLANDPERVAHIMLSWHSLDLVSCNKLQTLWAGYGTICAITARATTNEAAEHLSKLCGVETRAAGATYPLILKLISPPSKGANQADEGHLRKMLSYEVEQNFYSDVVPLLGDEIAVAQCLASTRQMKSKKGEAELDGLLATIMADLSPRFPVSGGKRSALNQTQVHSALEWLARFHARSWDLLPDSLDRYILPPLQENSRRGRQCTGNDDIGQGLWLNGGYTYLATRRSEYASLARDTHSEWSDPMCKAWPGCSLSVAEMAAWFLTPRGRPIESYIHGDVKSENLFTNRNGEEVAFFDFQYVGLGLGVCDLAKLFTCSVPLKMLVDAEQLLPERLAMRDGERRLLKQYHNSLLRDKKPDFYEWTVFERHWETALVDWCRFQASWGFWGNTEWLEARVRSIIGDHGWRDWLLQNIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRN1</accession>
    <name>A0A1Q5TRN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="9660" checksum="969A49C61CB25F62" modified="2017-04-12" version="1">MRKRSRLPHEYTKPVTYWGTGSFQKLKKYIDNGGDLNWRFAYGDTWAERVTELQTRCNPLRKNTPIGRVDGLNGGFGESVIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUD6</accession>
    <name>A0A1Q5TUD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUD6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUD6"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP03841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="665" mass="74652" checksum="4FAF6A1BE73B3B01" modified="2017-04-12" version="1">MPAIPARILRACTGRSLYMSTTTSLNSQTRIRLGQMESHLSTSSNNNTTSPSTTPPGTMSLADLPKSNVFTSKLPADPAFETPEASHKAPRQTLGPRMVKGALFTYVRPEVVESPELLGVSPRAMADLGLKPGEEQTPSFQALVAGNEFAWSEEKGGVYPWAQCYGGWQFGSWAGQLGDGRAISLFETTNPQTKKRYELQLKGAGKTPYSRFADGKAVLRSSIREYIVSEALNALGVPTTRALSLTLLPKSQVLRERLEPGAIVARFAESWLRIGTFDLLRARGERDLIRQLSTFIAEDVFGGWETLPAAISVGEGQTAAEMDNPPRGISRDEVQTQQGVDENRFARLYREIVRRNAKTVAAWQAYGFMNGVLNTDNTSIYGLSLDYGPFAFMDNFDPQYTPNHDDHMLRYSYKNQPSIIWWNLVRLGESLGELLGAGNKVDDEKFIKDGVSEDMEAELIKRAETVIERTGEEFKTVFLNEYKRLMCRRLGLKTEQESDFQKLFSEMLDTLEALELDFNHFFRRLSNLSLSELDTEEKRVAAASVFFHAEGFGGIGYTDESARARIAKWLESWRARVIEDWGNDGDNERQTTMKAVNPNFVPRGWILDEVIDRVEKKGDRALLGRVMQMSLNPFNEEWGLNKAEEERFCGDVPKYKRAMMCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXM2</accession>
    <name>A0A1Q5TXM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP04960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXM2"/>
    <dbReference type="OrthoDB" id="4235511at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013135460" evidence="1">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP04960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="129" mass="14451" checksum="6ED4955D723BEBF9" modified="2017-04-12" version="1">MRFQTLTAISLTGLLPVSWAAECWNRHAFRQDCVSRDQLDEQAWSWCHSHYNALDGDWQNLSPYQHVKIGKIGNFPDAATCVDAWKDATVCDDPNSGLHDAGASTWVWKNRDGSVGEAALEIIFCKVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXP5</accession>
    <name>A0A1Q5TXP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP05008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TXP5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP05008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="200" mass="23015" checksum="7B31CBE91F04EA4C" modified="2017-04-12" version="1">MKQPTSHEYQSPDSVEYIALLQQALYGLRQAGYLWHNVFDKDLKDIGLTLLPTELCIYTNHEKNTFVLIYVNNVLSTSLNSEIKRIRDTIALKRKLKILLFKRFLGYDIFHDQKKGIIFINQQIYLSTLISDEGFANASPASIPMDPSWRTTDDDVVDNIEKLDYARKMGKMPMHTKTSSAISQAQLTXEYHLEETQPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4C6</accession>
    <name>A0A1Q5U4C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA delta isomerase 1, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4C6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4C6"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000081">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="270" mass="30326" checksum="B9CEA9C62F76C32D" modified="2017-04-12" version="1">MATLFSVPITSTGGTIVCTKQGKEEENIYVLTFTSPKDNRLTPTFIDAFILALDIIEHRYPKGVVVTTSGIPKFYSNGLDLDLATSTEGFLDKWLWRLFRRFLTYPMPTVCLLNGHAFAGGFMLAMYHDYRIQNPDKGFLCVNELEFGVPLQTPMMSIFTEKLTPTTFRSVVLEAHRFGGHASLKAGIVDAVGGLDEAVGLIRDRKLLNKAATGIYGTMKEEMYSRVLNGLDDHAGNLAWRDKVEDRNEELRAEGLKEVEKWEKSYKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U735</accession>
    <name>A0A1Q5U735_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U735"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="109"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="60883" checksum="4C909825DC192A4C" modified="2017-04-12" version="1">MFDLNWKDLLTNRDRRGFPEVVLPLASGSAPKTQDPTNNGSNSSLDRASLQEKGTSGAHAGTTLTLEALRAEVESDIAASGHDTVYDRKAKIINRAVQDIGMGRYQWGLFVLCGMGWVADNLWLQGVALTLTPVAMEFGVSETDSRFATCSLFVGLIIGASFWGIASDAIGRRPAFNMTLCICGTFGLAAGGAPSWIGTCALYACLGLGVGGNLPVDAAVFLECLPPNSSSILSGLATWWSAGTLIASMLAWAFIPNFSCESYATCTKANNWGWRYLVLSLGAMTFVGFLCRFFLFTLYESPKFLVSRGRQEEAVAAVQGIAYKNKTTTWLTEEILNEIGGYPEEDKKQGLSTGEIIKRSLERFSYQQVAPLFKNKRTALSTILIWFCWTCIGMGYTLFNAFLPQYLSANSTTYETYRNYAITAVCGIPGPLLGWVTVDIKYIGRKGTMAGSTLITGILLFCFTASKDPNIQLVCSSLESFFQMIMYGVLYAYTPEVFPAPNRGTGSGIASCLNRIAGLMAPIIGIYASTDPVAPIYAAGALILASFVAMCFLPIETQGKQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U820</accession>
    <name>A0A1Q5U820_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U820"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U820"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP08604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="40422" checksum="D5369DE7BAD89FE9" modified="2017-04-12" version="1">MGSLTLEFTRLSQLTGNPKYFDAVQRITNELERGQSKTKIPGLWPLFINAKDLTFDWSQYSLGGSADSTYEYLPKEHILLGAQTDQYRSMYENAIEAIKKKLLFRAMTKDEDKQILFTSNVRGLKGGALHSVQYIQDHLKCFLGGTVGIASKIFNRTEDLSIARGLTDGCIWAYDSMPTGIMPETLEVSPCAEIDKCPWDEGKWYEDVLGQPIHSREHLERAQKQVEDEGLPPGIVGIADPTYKLRYNLHSTILVAVPMWSVVLIISLRPEAIESIFIMYRITGDKSLQDAAWRMFQSIDKVTRTKYGHSAIEDVRNPLPKMSNKMESFWLAETLKYLYLIFSEPNLVSLDEYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA23</accession>
    <name>A0A1Q5UA23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA23"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="14459" checksum="2A3F38CAF4DC8D86" modified="2017-04-12" version="1">MAGRSKYNSRLPDGRRSVYWSNNPACSFAYALTHVGARKVLELTGSAQDKAFDVKMMGECKVGNLKCISVVPEVIHQYFPAEEYGVKSLVDIGNGEVAGPSDAIFESTKGSTENILYSARCQSLWGETCLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAU5</accession>
    <name>A0A1Q5UAU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAU5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAU5"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7628" checksum="982F8A04328351DA" modified="2017-04-12" version="1">MQELNGGYENAREMMQEVRLYLEQIGVQMEGEDEVLLDCGRKWEDVFTVVQTDGVRWGREIRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB33</accession>
    <name>A0A1Q5UB33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB33"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13590" checksum="D85ABC56A7AF45B3" modified="2017-04-12" version="1">MKDLIDRRSKSPPSPLKLVVDQILKGHYKALHNTALLVKENADLRAANEKKRQKRTRSTRRIEHKAGLSIEEGLQLAQQPIQPVEADEVVSHEEVDLPNQPIQPVRRAPPTCSGCGRIGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBV2</accession>
    <name>A0A1Q5UBV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBV2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBV2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="32325" checksum="5F8DFC2DB2C85B8E" modified="2017-04-12" version="1">MPFSHHSHSGEFCPSHAQNTLDQVIQTAVGQGMEVFCLSEHMPRSEDELYEEEILVGFESEWIQSSILRGLISDSLSRYPFEFFVGSVHHLHGIPIDWNRALYSKARDVSGGTDERAFEDYFHLHYEMLQSLKPPIVGHFDLIRLHCDDPNLSSGRLQKWPGVWQRVKRNLKYISTYGGLLELNSGALRKGLEIPYPTAEICQEFLSMDGRICLSDDNHGVAQVGAKYHEIFKYVQEQGIQNLYFLELAPAGMTGGLDPRFPRTLVKCRSMAEVKEMEFWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBZ7</accession>
    <name>A0A1Q5UBZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4428</name>
        <name evidence="3" type="ORF">PENSUB_4586</name>
        <name evidence="2" type="ORF">PENSUB_4587</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000411">
        <property type="protein sequence ID" value="OKP10005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000410">
        <property type="protein sequence ID" value="OKP10006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000381">
        <property type="protein sequence ID" value="OKP10165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBZ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15691" checksum="697712C4AC2D4A54" modified="2017-04-12" version="1">MVPETTPDATHRVVETERITDRLQRLYKWFFFLAALLGVLAVNALTFPEFHPAQNAPAQLSHGLLCSALVTSIISAVILLMLLFEFDETASPPRSGLHVASICQLDTFLMGGLNDYGAVNKPLHEQLALFQGLEHQQKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDF3</accession>
    <name>A0A1Q5UDF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000315">
        <property type="protein sequence ID" value="OKP10492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="423"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="3">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="887" mass="100830" checksum="14C4E222B1DF280A" modified="2017-04-12" version="1">MVRMCGEGLQAPCTSSDTATGERTCRKRFPKPFTSETIPNEHGYPQYRRRDLPDMAFTKHVKGREVTVDNSRVVPYNPYLTVRYNCHINVELCRGVEVVKYITKYAYKGPDRATVQLTLTDEITEYLEGRYIGPSEAIWRLLGYRVHEEFPPVLALPVLLPSQQPVRFPTGANVDDIRHRMDNALSLLMAYFDYNTVARQQGRPTYLYQDMLRHCIWDRCQRVWRPRKNGTVIGRMYHVSPRDGERFYLRLLSTVRHDAVSFEDLRTVRPGSTERTFRDACKKLGLLEDDNHWRATFTEAMTFASGKSLRNEFCVAVVHGDVTDPPALWDEFQVHLCDDLHRQLECLTEAGRELPATSTREQYLDFGLFLIGRLLARQSKTLADYYMPSPEAHWSAFQPSSREGLHNMPLDRLTTAAAKLRDQLNNDQQAIFSAVVSTVLDGRPSAWYLQGPAGTGKTFLYRTIYAELRRLGFDVACIASSGIAATLLPDGSTAYSYFGIPLELHEDSTSTLRLRSAKFRRLRTTALIIWDEVPMQDRYAVELVNRLLQDARNDDRLFGGLPVLIGGDFAQTLPIVVPSSRTRTVAACLQRSSIWPQLTVLQLHRNMRLPLIGVNADYGQYLFTMSYREELRGTITLPQYIPRSDTVEELCDAVYPTTALSTTTGDLEFFAERSIITIRNDAVAVFNDQLISRMPGESRIYWSADRAQDRSGRDQPALTEQPLEYLHSINMPGLPPSMLALKVGAPIMLIRNLRQEDGLCNGTRLIITGLYRWNITARIIAGDHKRVEHTIPRIPLETTEGQLSFTLRRVQFPIRLCFAMTINKSQGQSLKQVGVDLRVPAFSHGQLYVALSRVTDVAKLSVLHEEGLDTTENVVFPEVLQRFDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDS4</accession>
    <name>A0A1Q5UDS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDS4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDS4"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="290"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="401" mass="44900" checksum="A3F4F5A583C41032" modified="2017-04-12" version="1">MNSVLARPLGSEGQSSKSSAIPVPDALSRLRPPPSRNGQINVDTFSPVNENGSFEFDRVLKTGRVSRRVKHKHVFRASWKPAYLVLRPNLLSVYKDEETTRLRVSISLSEVTAVAPVKSPRSNRKHVFGIFTPSKNYRFEALSERDAEDWINRIRGETPADEDEAAFLALSRKREPPAIQKQLVEDTTEHSDFEGASAGAGRASSPEFSHGLSTSARARKPPYTQDYSGNEITSYSELSDNGPSHTRNSRLRSMPSIHTLSLSAPEDKPMSLPRDTSRQSDLAILRDPERVVCQGYLQGLRIKGTVRQWKRLWVVLRPKSLAFYKDDQEYSAIKIISMSQVIDAAEVDPMSRSKTFCMQIIAEEKTYRLCAPDEESLARWLGSLKSILVARKKLEAGPSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDT2</accession>
    <name>A0A1Q5UDT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arylsulfotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDT2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDT2"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293415" description="Arylsulfotransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57492" checksum="00F970DAA94B3C1E" modified="2017-04-12" version="1">MLGLLCIGAFSFAACASANLAYKSRPDLAVPVLNITIPATSDVADGLIFYTPESTFADNTNHGPAQSGPYIFTDKGELVWSGFGFIGPRSENFQVHTYRGQKVLSIFEGSHNSPMGHGHGRTTILDNSYRYLNQIKGGGHKLADQHEFLFFDDNSALFTVFDPVIRDLSPYGATSDSQQWILDNKIQKVDTDTNRVLWEWSSLVHVDPVYTNLTLQSGNAGLGTNSSQVWHYFYMNAFDVDPETNTYLLSARSMCTIFKMDGNTGKIIWQLGGPNSNFSLGEGVDFCWQHDTRMHKKYLHHETKGSKEIISFFDNSAHENLTGGPDLQTRNYSAGKVVELDTKTHKATLIASFRAPGDLSVRSQGNLQLLPNGNAFINWGYNGAMSEHKADGTTIFFSKLDSGKFGPGSENYRAFKFEWHAIPYEEPALVAFKDSNGTSFYVSWNGDTETKVWKFFEQTASGRRFPLGNATRDGFETGFHTKKKVGLVFAEAYNSIGDKLVSTPAIEAVKYKAPLVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEF1</accession>
    <name>A0A1Q5UEF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Leptomycin B resistance protein pmd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3667</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEF1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEF1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF213">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="52"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="365"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="689"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="940" mass="103435" checksum="C662A7D6C9EC3E39" modified="2017-04-12" version="1">MIAVSVLGNIATPLTMIFKAASASTSFFEIIDSERIAAGGLRDSEALAQGDIYFKNVEFTYPTRPESKILNGLNIGFERGKTTALVGPSGSGKSTIVALLERWYAPEQGGIFLDERNIEELDLKWWRSQIGLVQQEPFLFNDTIFKNISFGLVGTRWENEPDSVKAELVENACKEAFADEFIERLPKGYETIVGENGTKLSGGQRQRLAIARSIVKGPTILILDEATSAIDVRGEKIVQAALDRVSKNRTTIVIAHRLSTVRRADRILVLRGGVIIEEGTHEELLGMEDGLYRGLVNAQKLEFAAEEDAGPMEVTEALEEELDHSTTVMSKQPEDVQEEKVKSRGFFQSTGVFIYEARSHWFLCLTAILGAMGAASAFPLQSWIFANLIDVFRLTGKELTDGANFWALIFFILSLGIAVCYAAVGYSANRLSVEISSSCRTEYFQNILKKPVPFYDLNENASGSLVSRLATDPKQIQDMIGLNGIFPVISVCSMIGCIAIAFAFGWKLSLVTVFAALPCVFLAAFMRIRYELQFEALNAEVYSGSSQFAAEAIQAFRTVSALTMEDSILNRYSGLLKQQQNKAFRKAWLATLVFAFSDSVELCAMALTFWYGGQLLASREYEPTSFFVVYMSIILGGQQAGQFFSFGPNIAQATSSANRILNFRPASEEVSAASGQRVADQSPGSGARIDFQNVAFKYASQEVPLFTGLDVTIESGQFVAFVGPSGCGKTSLISILERFYSPFRGTVLLNGEDINSIDQTSYRRSLSLVAQEPRLFEGTVRDNITLGLESSEYTEEELTQACIDAEIHDFITSLPQGYLTDLGIKAQQSLSGGQRQRLCIARALLRKPSLLLLDEATSSLDSQSEKLVQAALERLAGRRSMTIVAVAHRLATIQKADVIFVFGESQNGKGSRVVERGSHQELLQNRGTYWQMCQANGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF85</accession>
    <name>A0A1Q5UF85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein rsd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000298">
        <property type="protein sequence ID" value="OKP11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF85"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001012">
        <property type="entry name" value="RNA splicing factor (Pad-1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000876">
        <property type="entry name" value="RNA splicing factor (Pad-1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="273"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="467"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="349"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="564" mass="63800" checksum="3493CD01DA08B4BD" modified="2017-04-12" version="1">MSGLDVEALLESTAAPTETPVTKSEDQEDPSRADPSERRDRDRSRERRRRRDRSRDRRRDVDGDEEMKSPRSEHGSANGSHRSRKRSRSRESERRRSRRDRDGYRSSGDFYRGPGRARSRSRSPYDDRHYRPSRREREEERRHRRDREGGRRRSPSRRSPSKSPEVNEDERDKRTIFVQQLAARLRTKELMAFFEQAGPVKEAQIVKDRVSGRSKGVGYVEFKSEDSVPAAIQLTGQKLLGIPIIAQLTEAEKNRQARNPEASSGPSHSAPFHRLYVGNVHFSITENDLQNVFEPFGELEFVQLQKDETGRSKGYAFVQFRDPTQAREALEKMNGFDLAGRAIRVGLGNDKFTPDSNANRQQGPSANQPNFQGSSFSGHGGRGVQAGGTSNFDRAGGGRENDKGTGASALDDTDVAGVNFNNYSRDALMRKLARTDEPEPSADEQQKVLRPKTETKPLPVNVNMASRCVMLRNMFDPNEETGEAWIKDLEDDVRQECEEKYGHVVHISLDPNSQGDIYLKFDRVQGGENAIKGLNGRFFGGRRITAQPVVDAVYSSLFTRTKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFH9</accession>
    <name>A0A1Q5UFH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 25 member 45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFH9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="116" mass="13028" checksum="D4B6BD7BB53085E7" modified="2017-04-12" version="1">MKILLCGGIAGIVTWGSIFPLDMVKTRLQAQTIHEHSLAQTAPENQNLLRQPRATLNSYQMAQEVYRAEGMGAFYRGLGICSIRAFIVNAVQWACYEWLMKSFNNASVHVPVTDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFP1</accession>
    <name>A0A1Q5UFP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFP1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="519" mass="56413" checksum="BDDC7EDC9B10E293" modified="2017-04-12" version="1">MATEKSVEHSNIETVDRPDAANHDGKSALMSDNFFEHEQTVFQVIRSHPVLIWWAFFFSVSAIGWGFDAQVNGAVLSIPSFRRDFGETFEGGYVVPAPWLSAFNSISSVGQFFGGFLCSIFADRYGRRLALAVGVLITCAGIFGELFSSARAAFLISKLILGVGLGFYLTIGPLYSSEVSPVVIRGITTAGVNLGIVIGQLLSNAAIKGFGERNDHWAYRGPFAIQLFFVAFLAIGLPFSVESPWYLVRHEKIDAARTALQRLYGRNTSIETKLVAIQMTVAQDLAAKESKWSDLVRGPNRLRTAISCGVFVCQHLVGIIFVLGFSTYFFQLAGLPTENSFDLGVGTTACGVVGTIISWTIVNRLGRRMIFNWGMAILSTINLLIGILDVVPTSGASWTQAALTVVWAFFYQVSIGAVAFVLLGEASSPSLRAKTTAMATATQAVFGIVMNIVIPYMVNPDSGNMKGKVGFVFGGLGAIATVACFLYIPDLKDRTFEEIDVMFANRVPPRKMGEYVVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG25</accession>
    <name>A0A1Q5UG25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG25"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG25"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="592" mass="66435" checksum="C5A4DD827EB142C5" modified="2017-04-12" version="1">MAPPTPSSHRPRKKRKNPTAPGSNNSLIVDFGDGKQSPAFPLVSFLWAARAGVSQWLILPLTLMAVGLFRWAVSLWGYSGFNVPPMHGDFEAQRHWMEITAHLPVAKWYLYDLQYWGLDYPPLTAYHSWLCGKIGSAFDPAWFALDKSRGIEGPDLKVYMRATVLISEYFVYVPAVVNFLRRYTRMHGVHAWSASIALVAILLQPATILIDHGHFQYNTVMLGLMVASLDAILAGRMLWACIFFVGALGFKQMALYYAPVMFAYLLGVCVFPRIRILRLLNIALITLAAFAVLFAPLLYGATTMEARELFATSAEPPLLQSLPISLDKKSVAYALLFQTTQTIHRVFPFARGLFEDKVANAWCAVHTFYKLNRFEASLLQRASLGATLASIIVPCAIIFRHPRASLLLPALSCVSWGFFLFSFQVHEKSVLLPLLPMTLTLAGDGGLSKQNRAWIGWANILGSWTMYPLLKREELRLPYIVMTLLWAYLMGLPPTSFEIFRSRASPEESPLEPHILSKLLHLAFYLAMIGWHILEAFVPPPAGKPDLWVVLNALIGAAGFGLAYLWCMWNLVVQCREIDLRAAEEGSRKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG39</accession>
    <name>A0A1Q5UG39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG39"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG39"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="51444" checksum="2D2B67F79BFC0295" modified="2017-04-12" version="1">MDLDALAPRDDTSCSGSKQWYVCSAGNFRGCCASDPCTSGICFDDNVSLLHLTSAASSASSTTSSSSTSTIMKTSTVTIPTASSTTSSTTVSNTSASTTTSVSSETSSAAANSTEHSSSTTTTTATGGVAAASTGTQSSSKGPIIGGVVGGLIALIPVILLLWFCRRRRKRHGKSYTCHRRRSPSTKSLHNREMASVSKTELAQLETDSTKLHNESHHGSETASPPINSTTHSTLSTPGSTTALSSLSAPTVSPDPSEYSTLSSGILSTSSGGFARLPPLRMPNPQPPTEMEASIPKSESQTAAELSDTGFYRQRAELAAHSQSELINVPLERRRRKSPLNPGSSPSSSSGSGSSESSPRSAVDKSGSSPVTSRHTARRVVTRDGVVMGANLDRYSTIRDPERGEVKGGKKSDAGQEHVMSFMTFGGSEFEMVQRRGSGSPRQGNGGSASGSNEREGGSVSRASRSVPRVVLEDFGASSIGEAPPAYDAGGVALPKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG75</accession>
    <name>A0A1Q5UG75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG75"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="29681" checksum="5C7722ACBE0502D3" modified="2017-04-12" version="1">MDTANLLPLLEQLDDDVDDLEDALQPLLGSSLNKMSKNMPIFDKAKIHVLTTYTLESLIFSYLRLQGVDAKQHPVFREITRVRQYFDKMKALEEPEEPEQRTMVLDKAAAGRFIKHGLAGNDKIDLERAEREAKERARAQLKAAMLAKKAASTAVQDSPAQSESVYSAVPSTAQPSAEADDSDDSDEEMEADEPAKDFKTGEEFIEFETKKKKKKSKEDKAKQRNESGKKHGRKATKAERRQEKKDRRRKKEESRKAREAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGI3</accession>
    <name>A0A1Q5UGI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07114">
        <property type="entry name" value="ALDH_DhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="54037" checksum="BB67968EAEC725C1" modified="2017-04-12" version="1">MPDTYLLWVAGEEKAGGADLCHAASDEDVESTVAAAHVAFKSGIWSRASRHHRADVLEKSASLLSDALPELIPLESRQTGRVIKEMQAQVPSLVKWFKYYASLLRVEERSVLPTTGRLHNFIDRVPLGVVVQITPFNHPLLIAVKKVAPALAAGNSVILKPSELTPLTSLLLGKILAQAGVPAGVFSVLPGYGATTGKALVSHPLIRMVDITGGTVAGRAIGSIVGGNLAKYTAELGGKAPLVVFADADIDVAVNGIAFGSFIASGQTCIASTRIIVDSKIKDRLLQNLVDKVKAITRRIGSPQNPDSMMGPLVSAKQLQNVERLVNESITNETAIDFSGAKRMTGTSAFDGSNLSKGYFYEPTILVSRKDNESIIKSSIWREEAFGPVIVVVGFDTEEKAIKLANDTEFGLGASIWTKDLSRAFRVSEQIEAGIVWVNTHHRNDPSSPWGGTKAASGVGSENGIDAYHAYTTTKSTIINFAAPEESRTTDDWFGEKVKDVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGW8</accession>
    <name>A0A1Q5UGW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased recombination centers protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGW8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGW8"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="47621" checksum="6106B5588CB75EBD" modified="2017-04-12" version="1">MTPTASANSPADPSKSQPQTKHIANPRRLLILTPTSQSVSIIPPLLHSLTGVPVVDPPQHDSTLETPSQSSDDNTSTPPPTTTATTTTTSFAGYTTHSPLRLNTKYYSAEIPLWVDEIPLSTESETPAAAGTGAASSDTPTPAQWRTEFLSEEAEIVRDAVGALVVCVRSPESKQTTPSTSTADADTDIDDPASRPEVRAVLDLMRDVGAVKACIDEERGGYGDVPGVFVLVGSRSSAAPKSSAPDGETRLELGVDDVDLGDGAADTPFSVGWWEDQLFDLGLFGWEVVEWDPVEQGGEKTRNKFGEYEGMPRIKEVLETHDWSTSGAADDLDHADLDFGDDLEEELLGFGRSAHTSGFGHEVQELEREMMGLRMAIERGGGDGDQSDADLDLDDGDEELKVESIETLMMRMQAIRDMGSELPEGERRKFAAKAVSDIMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGZ5</accession>
    <name>A0A1Q5UGZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_2622</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGZ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9 15" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="341" mass="37358" checksum="1495329D27AC3DAB" modified="2017-04-12" version="1">MDKIVAQYSRPSYQNVYTEQDQQELTESLPPLSLKFALPPVANVSYSNTNKVIHGLEAGCHELGVSGQSSGGPRSPSSQLWRPELPAERPSAFLRAMTDDHSNPSCPIKLAHGTTTLAFRFQGGIIVCTDSRATAGNWIASQTVKKVIPVSRLSRGEDKPTSEPTPGLLGTMAGGAADCQYWLRYLSQQCTLHEIRHKRRITVAAASKILANLTYSYKGYGLSMGTMLAGVTPQEGPALYYIDSDGTRLPGNLFCVGSGQTFAYGVLDANYRYDLTEQEALALGRRAILAAMHRDAYSGGFINLYHVKEEGWVHHGFDDMNPIFWKTKLESGEFSNVTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH71</accession>
    <name>A0A1Q5UH71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH71"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="10278" checksum="6A28E15E9A2C3A1C" modified="2017-04-12" version="1">MGRRDEALFILKRVRGTANERAAIFEMREIETIVELEKESEDHITYFDMLLGTGNENLHIARRVQLVVWLQILQSWTGIAGVTMYAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHF4</accession>
    <name>A0A1Q5UHF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent protein deacylase SIR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHF4"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="385" mass="41995" checksum="69A0BB7266F584BF" modified="2017-04-12" version="1">MTTPAIRIPFTGPLPPAIIVPQSARSIAGAIDAVSAFFTAPPSLHLRGIDVGRNTQTVLLTGAGISVASGLSDYRGDQGTYRRNKSYRPIYFHEFTTRHESRKRYWARSFVGWPGLVKATPNSTHWAIRDLGAKGYISSVVTQNVDSFHSLAHPELSTLELHGYLRSVVCTSCRNRFSRQEFQNSLERLNPAWAEFLARMVDAGALDTDNPEEQRRKGLKLNPDGDVDLAEAPYSTFRYPSCSTCLEKPPILKDGRRGYVEVEPDGAWLPTSTAGILKPAVTMFGENIDPAVKIAADEAIDDAGRLLVLGSSLATYSAWRLVERAYKRGMPIGIINVGGVRNEAMLFGQVGSGLEGSNFGTHVRCSHPAQAILPTVVSGLSMNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHV4</accession>
    <name>A0A1Q5UHV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3445 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHV4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHV4"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35076" checksum="12D622062B34FC77" modified="2017-04-12" version="1">MGIETVDRNDLLLFDQTYSERLSLRESLLREYPDDVVGVTNESDTRIRLAVQELYNYLFQTYLPVRYPSIFKIYENKDSSTAMLENLVTRQTLPMTMTVSTPLHGALRTIAQNVDEDFFILLPQRQEDSSEEVYVLEAYAACFPSGFQPKEKIGKKLAEIHGPVPGYKEKLQKSMDRFFARLDPGRYVKRVNWSLTVDEELFSNFDKSKPAFEGTLKNLSVEDLDLEKTFLRCERQTLHRLPNSGAIIFAFHTYLYPIQDIKDEGSGEDLAQAIDGLENGSVREMFTYKNGDKWANAVREFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHZ6</accession>
    <name>A0A1Q5UHZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000246">
        <property type="protein sequence ID" value="OKP12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHZ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHZ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="29613" checksum="A6ABA7C7AD670390" modified="2017-04-12" version="1">MHAGRTSWHNNILLHLKSSSLIQRLRRPHVRDAGFVNLRCDATNTCTEIQYAVHGQYPASVFTRKGIDYLPQLELEYAEFNRLWDGIFPGQPVPSAIGTHTGAQFALTRDIALRVSLAELKRLRQWIVDTDLTSKSAGAVFEVVWHMLFLGTQASVICPAPLECYCALYEICIQAVNKDADRLLDDVSQEGYRAYEMGRDLGRIQRLIGQSPSDERDGELESISGSRIGPDLAGLSKYTADIDMYIAKTTERLNRIVKEADAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI12</accession>
    <name>A0A1Q5UI12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI12"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI12"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="36806" checksum="99BCFB774521B576" modified="2017-04-12" version="1">MATNLPQNVRAVLQPDPKVDTLILTETALPMPKEGDTEEHLVQIKATSPCLSELTWERYFPEAFTTDRERVPGTEGAGVVVTAPARSPFKPGDEVYFRNHADRRGCLSDYTLINKSSLALKPKSQSWVEAAATPLSSLTAYQGLFEHGLLNPRAIVTQGGDAKAREANGKVRVLITAASGSVGSWAVQLAAAAGAGAIVAMSGPSKVDDVRKAGATDIIDYTKQSVADWAAQDPSSTQCDMALDCVGGDSLAGCWTAVREGGVLLSVSDSPDRVRPASVASKKLAKATWFLVQPRGSDLAEIAKVVDAGIGKPWIDSAVEFEDFQKAFDKVETRHAKGKVVIKITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI13</accession>
    <name>A0A1Q5UI13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein RTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000248">
        <property type="protein sequence ID" value="OKP12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI13"/>
    <dbReference type="OrthoDB" id="5306317at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="32780" checksum="18999802561A2155" modified="2017-04-12" version="1">MVPPYFELSWSILSTIGLFLTVVGFWAIFITRVSPLHLVPIVVSIACAVANGLCYYAFYAEHPTRQLVVASVFADLFWLIQEAGLSFYGYQILVHTLKDRALVIFRTIFWTLMTSIIAIRIAIAATRAIDVATDKPLQQRVDYLHVGYFIAIALVETSSALFLIRLLRDAYRMSPWTSPTRDLFRHLLQSTEIRLASLCCIGILRAVTFSLRTTAQSVTNVASEFDRFAYTLECLFPVIMIIDILASKRFRFDSHSLIYCSDPPDGHQAWVGHPTQRHSQWAAMSPEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJJ0</accession>
    <name>A0A1Q5UJJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJJ0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="521" mass="59337" checksum="BF7087DAD6F1B393" modified="2017-04-12" version="1">MPLAVGQSALKGEVEVAQAEMPILEEVKWWREPGLRRLYFWASVLCVASATTGYDGMMLNTSQNLDSWQQFFNTPSGSKLGLMNAIYQIGSLASFPFVPYMADRWGRKLPIIIGCLLMILGGFLGAFCKDYGMYVAGRLFLGFGNSLAQMASPVLLTEICHPQHRGKVTTIYNCLWNLGALVVAWIAWGTMYIENDWSWRSLTILQVFPAVIQIALIWWVPESPRWLISKERYDEALQTLAYYHGNGDEYNATVQFEYREIKETIRLEMTYQKNSSYLDFMRTRGNRYRLALLVSLGIISQYSGNALFSNYTSLIYNSMGITEQTKKIPLNGGQTLLSLVVSISSAFFVDRVGRRPLFLISTAGMVLMFLAWTVTSSVYEKTQDVKTSGYPQVVFVWLFSVFYAIAWSGLLVAYSLEILPYRLRAKGIMIMNLTVQASLVLGNYTNPIAWENLPHHWNLSLIYTIWIFIELLFVYFFYVETRGPTLEELAKIFDGEDAAVAHVDMYQVEKEVEATHHERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKI5</accession>
    <name>A0A1Q5UKI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Beta-galactosidase</fullName>
            <ecNumber evidence="4 13">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_1351</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 13"/>
    <dbReference type="EMBL" id="MNBE01000165">
        <property type="protein sequence ID" value="OKP12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKI5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKI5"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000088">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.390.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012637740" description="Beta-galactosidase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="16">
        <location>
            <begin position="396"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109694" checksum="0E8C80BC0C47C8C2" modified="2017-04-12" version="1">MKLVSSWVVAALAAQAASAAISHKLDGFTIREHADPAKRALLQKYVTWDEHSLFINGERLMIFSGEVHPYRLPVASLYIDIFEKVKALGFNCVSFYVDWALLEGNPGHYSAEGIFDLQPFLDAAKGAGIYLLARPGPYINAEVSGGGFPGWLQRVNGTLRTSDAAYLKSTDNYASNIAATIAKAQITNGGPVILYQPENEYSGACCGVSNFPDGSYMQYVENQAREAGIVVPFINNDAWTGAHNAPGSGAGAVDIYGHDSYPLGFDCANPSTWPSGNLPTYFYNSHEQQSPSTPYSLVEFQGGAFDPWGGVGFAGCAALLNHEFERVFYKNDFSFGVAFLNLYMIFGGTNWGNLGHPGGYTSYDYGAAISESRDITREKYSELKLLGNFAKVSPAYLVANPGSLTTSAYTNNANLAVTPLLGSNSSASSFFVIRHSDYTSQASAQYKLTVPTSAGNLTIPQLGGSLTLSGRDSKIHVTDYDVAGTNILYSTAEVFTWKKINNEKVLVLYGGPSEHHEFAVSGESSSSVVEGSSSGISSKEVSNALVVAWDTSSTRRIVQVGNLKVFLLSRNSAYNYWVPQLPTKGKSPGFSNQETTASSIIIKAGYLVRSAYLDGNDLHIQADFNATTPIEVVGAPSGAKKLVINGEKTQFKVDKNGIWSTSVTYNAPKVRLPDLKKLKWNSIDTLPELKNTYDDSDWATADQAYTKNTAYPLKTPTSLFASDYGFNTGTLLYRGHFAANGKEKTFFVQTQGGSAYGHSVWINETYVGSWAGNSIDSNHTATYTLPTLQSGNNYVITVVIDNMGLDENWIIGLEAMKSPRGILQYSLSGQEASAISWKLTGNLGGENYRDTVRGPLNEGGLYAERQGFHQPQPPTKGWGSNSPFTGLSKPGIHFYSASFDLDLPSGYDIPVYFNFGNDTSTPGEYRVQLYVNGYQYGKYVNHIGPQTSFPVPEGILNYCGTNWVALSLWAHGDNGAKLDSFELINTTPVLTSLGKVKSVNQPKYQARKGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKV5</accession>
    <name>A0A1Q5UKV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc metalloproteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKV5"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="82422" checksum="90B1C06B80DA267C" modified="2017-04-12" version="1">MVKRTLDSDSTTQRRVKPTLVDWRPFKITNLDDGEVVHQTSLIIHGECQNFDYAEETNYVSVSTSDILKRSHSAQNWPLNKGQWSALVMLSPGTNKLSFKLHHVGGISGSLEISVNYLPLLQLPPLHLAILVAKDSSLLIDCPPAKYGGVSSAHSSIDAAISKLRMSAYMWQAFTAEDFRQKGLGRRSFRLEEEWSPNTTMQKTHQYVPGDSNQMGPMAKVHIIRSEKTVAELRNANVAQQNPRGRDRDALHGYFEQALIDAGAPFDSKSRPIVAGLILDSHYSTQQSLITAHAALGCHKPGGVSLGIFGSHLTYSWPRFIEEIPACLTDMTHPGETVGNDNGECDTMRGACFVGQGAFMHEVGHAFGAGHTTGIMARGYSKSWGMNFIQHKDNGSMKNEAKWDLQDTLQFKLLPHFALPGDDPVTKSFQKANVKIGVSLGGDDDPMDPEDKTEGLKISCSAGLAQVKIQTGEGNPVVHDFMGDGKPPCTEFKITEIREEFDQTKPLKITALGLNGNKRVVADFWALLKDLPFVLIPDSDVVIQKQSVRSRNLEAAENDDNFMKWAMLLHHRGADGKLHPATSIDLRVGCTMDGAVVYYADGKHANCGPARNSHNGQPHRFGGHASQRRDIPAGEQITQVKICKRDDGWGSLSGIRMTLSNGETWGALNTTGNGDDEDEDDDNDSSDENDQKDESDIVILEPAEDEVIVGFYGKSDKGCGFTYEFGILTVPKGVELPENAYDMAELRNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKY9</accession>
    <name>A0A1Q5UKY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-carnitine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKY9"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="376" mass="40851" checksum="4B6FE1DC8996AF79" modified="2017-04-12" version="1">MSKYPHHIALLGAGTIGLSMLAMHLRRPDTRVTVFDPRPDAEDQLRAQLPSFLDSSQYTSSNSNPTSSLHDLSSDTLIDTLISTNRLRLASSIHETIQNATIIQEQTPELLSSKQALWAEVTRSANINAHLWSSSSGIPASAQAATCTADVQARLLIAHPFNPPHIMPLIEVVPSPNTAPDRVTFVQEYFKAIPGPRAGQSYSITSQTPSTSASASSQHYRPVTLQKEIPGFVGNRLAFALLREACYLVGEGVVSARDLDAIVTSSLGPRWAGSGVFESYHAGGGEGGIGAFLEKLAPTVKDVWGQLGQPVILTEEEREIMSRDDSEGRDQEKWRETVVKQTEEAYGVGISAETRAKKVKMLNGVLEMQKECFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULP2</accession>
    <name>A0A1Q5ULP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_894</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULP2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="489"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="973" mass="108892" checksum="80B321168293FFDA" modified="2017-04-12" version="1">MDPLQPSDSAANRGLRANTRKRSREPDDMSSPAQLPPSSPAALGSSPPPMPPFDEGEDDDEEEAEMIPDIDDVDELAEDEDGIDLFGDNFERDYRAAEDDRYVNEAYIDDDEDHDELDASTRRQLDARLNQRDRELARRRRMPAAFLQDDDDMDLDLSRQPRRRRHHYDEEREDIDMADEGMDELSLEELADVKAANITDWVTQPQVLRSIYREFKAFLTEFIDPSGQSVYGNRIKTLGEVNSASLEVSYAHLSETKAALSYFLANEPTEVLKVFDQVALDVTLFHYPQYHDIHNEIHVRITDVPIIYTLRQLRQSHLNCLVRVGGVVTRRTGVFPQLKYVMFLCQKCGITLGPFQQEASAEVKISYCQNCQSRGPFTVNAEKTVYRNYQKLTLQESPGTVPAGRLPRQREVVLLADLIDSAKPGDEIEITGIYRNSYDAQLNNKNGFPVFATVIEANHVVKAHDQLAGFNLTEEDEREIRALSRDPEIVDKIVRSIAPSIYGHQDVKTAVALSLFGGVSKRAQGNMSIRGDINVLLLGDPGTAKSQVLKYVEKCAHRAVFATGQGASAVGLTASVRRDPLTSEWTLEGGALVLADRGTCLIDEFDKMNDQDRTSIHEAMEQQTISISKAGIVTTLQARCAVVAAANPIGGRYNSTKTFSENVELTDPILSRFDILCVVRDLVEPSEDERLANFVIESHHRANPAKPLRNDQGDLVDTNGDLIDIDGYRIDGEGRRLPPSQEELARRAAEQKRADEEKEGEIPQALLRKYILYARERCHPKLYQIDQDKVARLFADMRRESLATGAYPITVSNPFASLPTVQMLIYFLVQIRHLEAIMRIAEAFCKMRLSEYCSAQDIDRAIAVTVESFIGSQKVSCKKALSRAFAKYVALNLPSHPGFSSFNTLSFQVHTFPAQAAIQAPCRHPSVKPTSASLYAHESLSIARGWGAFWGFLLSKIPSLFASGVYGVPIIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULQ5</accession>
    <name>A0A1Q5ULQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULQ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13405" checksum="9501130CD399385E" modified="2017-04-12" version="1">MLERLIHQMFDFKCLFTKEDTKVGDLFPTQHSTNPPGNPFLWQASRILIDGESSNVDEERFQKANNVNAVESALLNHLALMVAKLSFQDVASGFEAGKDQTDASPASNISSRFSEPVDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM06</accession>
    <name>A0A1Q5UM06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM06"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="232" mass="26254" checksum="0EC94279C9D7A8A5" modified="2017-04-12" version="1">MESYEELEPVNVHSTIDILSGLSNMASPCPLIYVSGGYMPSEHESLSEVAKKLSSAPGYGQTKFMSELLLAEYKKHLDKQKGNIPKARTIIPGFIVGTRQEGIAHQEDYLWRFAFSISRLRAVSKDLLGHLNVAGVDQVSNLVSDVLLQPDRCVPHAIKCFDGVDVLILCNILEDKLKIKIRKVKHVEWMRILRSDIDDADFDHPLNLCLNGCKQTPWVPHLKVLFSMRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM59</accession>
    <name>A0A1Q5UM59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM59"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013248288" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="234" mass="25526" checksum="C248745143A94FBF" modified="2017-04-12" version="1">MTQAGTTALAAAMMGAGYLCALCATPPNPSPDRKDRHTTDRISFIAGSGATIARRIAVTAVTYHALLTALPVYAPQRMSQMCPRPHNLNPELFSWSIPAIAGILLICLGAYVRLAAYGTLNRNFTFHLAAPDKLVTSGAYGWMQHPSYTGLVLIGFGVASLFCRWDGVPACWISEATLARWSGWGMGVLGGYISVALCVLFTRVKDEEEMLKGKFGKEWEEWHRSTKRFIPGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMK9</accession>
    <name>A0A1Q5UMK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMK9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="617" mass="70088" checksum="26CC203A68410A38" modified="2017-04-12" version="1">MPADPRESRTTKGSGVVKSAPSRKRKATANSSPAPESEHSNIRRRSQNVKDIPEDPISSLSASTVISAIETYRKKFPIANFLHYPSLISDVSSSFESVDSVFIASLLSLCVRFMSSDGLEDEETYAGYAQKHLPHRVMEAPSLYLAQSLVMISFYEWGTGRPYQAWMYSGMATYMIQSLLKMADDSMEHSPHEFHASQTQYEQLVRTYWCCFAQDCELSSGARQHFALSFSQISVPLPISDRDFTFNQLPDRRLMPVDMNKKCPQANNLTIENGLTIVIRGFDIFVRILRFANEHRRSLASFSSDESPTSALHKTWHRLKAELDEWRSLQDRTVKYPDTSAQAHVALGYGELFAYINLLYFMSIVFLHRDRFLSNLKPHSDVFHDMTDDDQYQPDTIQQLFEAAQHISSILSALEASEASVMTPYSGFSVFVAAHINMYGTLVPQRYPGGLDRAEDEKTQNMMYLERLSTLWPVGRSWWRTVQDANRFYETVKSTQTHPESVMHSPRRFALAGTLDEYGDIRSRPNRELDTTRAMTAEARELQNTHQEQGRTSSSPGHEGDVAFFSKEQSATGSHPDLETDMFQWPFIDASWSVGFDAGLDGLWHHSGLFDPNSAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UND9</accession>
    <name>A0A1Q5UND9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_266</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UND9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UND9"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000005">
        <property type="entry name" value="Fatty acid oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121203" checksum="A4E4202A5646CB2D" modified="2017-04-12" version="1">MVHNNGHANGAESPLAQIEQVIKASLRPMPTETGDGTYVKGNTTTGLAQDLSHVDLKDVKTLAEVAKSAITGDPVNDREYIMERVIQLAAGLPSTSKNGKDLTNTFLSTLWNDLQHPPISYLGRDSAYRKADGSGNNPFWPNIGAAGTPYARSVRPQTMQPGALPEPETLFDSLLARKEFKEHPNKISSVLFYLASIIIHDLFQTDPRDQTVSLTSSYLDLAPLYGNNQEEQNAVRTFKDGKLKPDCFSTKRILGFPPGVGVMLIMFNRFHNYVAEQLAQINEGGRFTKPDESNTKAYATWDNDLFQTARLVTCGLYVNIILKDYVRTILNLNRTDSTWSLDPRAEMKDGLLSDAAKQATGNQVSAEFNLVYRWHSCISARDQKWSEDLYKEIFVGQDPDKISLQQFTMGLGKWEAKLPEDPVERPFAKLQRQADGRYNDDDLAKIFEESVEDVAGAFGASNVPTVFRTIEVLGIKQARSWNLATLNEFRSFFSLQPYKTFEEINSDPYIADQLRNLYDHPDLVELYPGLIVEDAKDPMLPGSGLCANYTTSRAILSDAVTLVRGDRFYTVDYTPKHLTNWAYNEINYDTSVDEGAVFYKLVLRAFPNHFQGNSAYAHFPFVVPHENKKIMTSLGRAAVYSYDKPTYKAPPRMISSHAACMSILADKETFGVTWGKKLEFILSRDGHSYGGDFMLSGDRQPNVESRKMIGNALYRDKWKSEVRSFYEEITLQLLQRKSYKIAGVNQVDIVRDVSNLAQIHFCAHIFSLSLKTDSNPRGVFTEQELYQIMALVFTCIFYDVEVTKSFQLEQASRKVAQQLGELVMANVELVNKSGFIADIVNRLHRHDSLTDYGVHMIQRLLDSGLPPKEIVWTHILPSASSMVANQAQLFIQCLDFYLEPENAHHLAEIQRLSREDTPESEELLLRYFMEGGRIRSSVALPREVVKPTVIDDNGEKITLKAGQEIFVNLVAASHDPKAWPDPEQVRLDRDLSQYSHFGFGPHQCLGLGVCQVALPTMLRVVGQLENLRRAPGPQGQLKKLPALGGLTMYMDAEHSMISPYPSTMKIQWDGELPKMAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNL5</accession>
    <name>A0A1Q5UNL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNL5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="54294" checksum="7F76FF7F3C71538F" modified="2017-04-12" version="1">MAGASQSPPVQIVLCFDGTGNTFEVNGTDTNILKICRMSPRSDHQSGIGTEITPGSLAATTLKKSSRLGGSKTLSQALGKSFDRHVLGGYRFLMRHYRSDGNIYIFGFSRGAYTARFLAEMLDYVGLLGPDNEEMIPFIWDAFSRWKLTRYNGDTEKGSWEQMQAKQFMYSCRDTFCRPMTRVRFLGLFDTVNSVADFEINNDDSSSARVIRHAVSIDERRVKFQPVLLPRSRGGFGRKTAVPAVNSSPEEDGGTEDSENAGKEASKAFGQTPNADAQTEAPDEDDEVQDVQEVWFPGSHADIGGGFSVEEGEAWQLSHAPLVWMVQEAQRAGLEFDQEKLQLYNCLGEEHLDPSSVARFRHALVTSSAKGALHDRLGFGTGLSAVSVLAWRFMEYIPIRRASLMESGNWELIHWPLHRGYPRDMPLDAEIHGSAIHRMQKDPNYRPGNVIVGGGGRGVKRAPEAYGIGNLKVHSHEGDLVRHTYVQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNL9</accession>
    <name>A0A1Q5UNL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNL9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNL9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF31">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="89638" checksum="8FAD74807E2D4D71" modified="2017-04-12" version="1">MPAEPDFDREDREDAPFLPSESNASGSANTHDHDHDHNDHTKPTQPVPATASAPASASKITFRLKLILFAMVLAVEIGFAFLDGPMVRVMESIACRQYYSEADPTKIGANGQVPEELCKLAEIQAELAAVKGYHMFFDGLLSALMAFPYGLLADRRGRKSTLVLGVPGFFLNSIITIAVLWFSDVLPLRAVWLSSLAWLIGGGPVVAFAIIWTMMADVTSEAERAGLFFQFAIVSMGADFVSSALASWLMTMDPWAPLLIGYAIVTGGLLFIFVLPETKHAIPSINLEPPNVELSDLTESDPKHTYHKPEEAGMYHDESDVDVGDHEAHMSWSYPTHQPQSFWGKCRANYRFYMKPYLFILNRKPVLLLLTAFLVYRLSRGSSWFLTQYISTRYHWTLAQANMLVASRPTVSIPVFLWGLPYLKKYVLNPRRTSTEKDLWLARASILCLTLGTLGIGLSPSVATLIPSMIIQTSGSGFVFLTRSIITTLVERDETARLYTVIEIIQSFGNVVASLSITTVFQIGLRLGGFWIGLAWMMTSSLFCMVAAAIWFFRLPPTPQTPESLSKQQQARLPQPGSIIASSFTSPIDAVYLAAIFDPIFTASYPNTRQVEHISLLQAILRAFAQPVTNPEPSTKLVDVSTLVETYPYRPIVIFPECTTTNSRGILPLSRSLLGVPSKTKIFPLSLKYTPVDVVTPLPGSYTSFLWTLLSRPTHCIRVRIAECIMIGRSSFDAPPARSTRKSTFNTNYLDTLDEDTATGEVTASEKALLDQVGESLARLGRVKRVGLGVEEKQEFVRMWNKTRRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP73</accession>
    <name>A0A1Q5UP73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Quinidine resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_32</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP73"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="426" mass="46821" checksum="C3EA44F8F38C8B7C" modified="2017-04-12" version="1">MYLPALDSMGKTLKVSTSKMYLTITAYMVTQGIAPLFTGYLSDIKGRRPILFVCLFISLACNIGLARQTSFTALISLRCIQSVGTTGASVITIAAIIDIVARSERGKYMAYSTMGSTIGTSVGPVVGEVLTQYLGWRSVFWFLVVFSGVAILLLVIFFPETCRAVVGNGSIPPQPWNKTLIRRRKSITPRYETQTKFRKPPRIVDSIKLLGDKQIGILILFWCLINWGQAAVQISIPILMTKNYGFNSLQVGLCFIPMAVGGIAARWSVGTFADWNFRRLARQVGVDVQRNLQTKEDLEKMPLEKVRLQIAFPAFYLCCIFLIGYSWTLAYNLHIAAPLIFLFFLGNAGVGATNVLAALIMDMQAYQPGMTRASMNMGRCLPIAGVAAGINPAIQVIGLGWLGTLFAGCWLVSSPALWVVYFQGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPS2</accession>
    <name>A0A1Q5UPS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_14078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPS2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPS2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7380" checksum="564ED6E5773DF527" modified="2017-04-12" version="1">MIGDVLHDRYHIVDKLGFGGYSTVWLARDSHLQRYVAVKINAAMLLRARQTFSGLYLLLFQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ69</accession>
    <name>A0A1Q5UQ69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000073">
        <property type="protein sequence ID" value="OKP14627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ69"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF62">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="562" mass="63473" checksum="93234C9665DA0B19" modified="2017-04-12" version="1">MPPIRTESSQKSANQEGRILLALDDIKNGRIKSIRAAAKLYDIPRQTLSRRTNGIISRVDTRANSHKLTQLEEDSLTEWILSMDSRGAAPRHTTVREMANILLAARGTTPLLTVGVNWVSNFVKRRDELRTRFSKRYDYQRALNEDPKAIKEWFLMVQRAIEENGIQPEDIYNFDETGFAMGLISSQRVVTRAEYYGRRSILQPGNREWVTAIETICADGYSLPPCIIFKGQVYIAGWFESSNLPRDWRIEVSDNGWTTDEIGLRWLQKIFIPYTTSRVRGRFRLLILDGHGSHLTPQFDRICAENDIIPLCMPSHSSHLLQPLDVGCFAVLKRAYGRFVSDLARTGYNHIDKLDFLADYPRARIEAFQPNIIQSSFAATGIVPVDASRVLSKLNISLRTPPPPSSRPSSRSSQFTPKTPKTAIQLEKQASMLKELLKQRSHSPPTPSKVMLDQIIKGHWIALHNTALLAKENDDLRAANEKKLQKRTRSTKRIAHKGGLTIEEGLQLAQQPIQPVEADEVVSHEAVDLPNQPVRPARRAPPTCSGCGQIGHRITSCKNRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQL1</accession>
    <name>A0A1Q5UQL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQL1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQL1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="38070" checksum="61FCCC7BB5098841" modified="2017-04-12" version="1">MPERSILNSRKVLVSGGTGFVGAGIARSLADKHPGCTITIIDLSPPQPQNALPEEIEFVQVDVTSMAEVRKTLQTFKPDIVIHTAGIVPALADRFGRRLERDVWWTNVQGTKNMVDAAVECGVKAFIYTSSCCVTTDDMRFPYPNINEEWPTSPTSLIYGESKAAAEALVLQASSGQMATCSLRPSVLFGPGDYQLIPSIHACISRYQTPFIIGDGFNLWDVTHVSNVADAHVLAAENLITSRTAAGEAFFIQNNEPITFRDFCLAIWAQFGHVPPFEIHIPEALAYVAGFVCELATWATRSSTTLSRGSVRDACAMRYACGDKAKFILGYEPRIGIEEGIRLSCEVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URF6</accession>
    <name>A0A1Q5URF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoporin NUP49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URF6"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="476" mass="49767" checksum="1488E6AA8084EEE2" modified="2017-04-12" version="1">MFAPKTTAPASGGLTISTSSTPLFGGNTNTQNTSTAATGTTGTSSLFGGNTASTAQSKPLFGATQQSSTPGSSMFGGNQQQQAGTTPSMFGGAQQQQQTGATSAFGGQQQQTGTTSSLFGGPATTTATQPAQSTGLFGQPATQTQAKPAFGLGASTTGGSFFNSTQQPLQQQQQQPAKPSLDVFRNPGTTQTAQPSLLGQSTATGTVVQGVKVDISNLLPTTKYESCSDELRKEIEAIDNAILGQMKLCHEVADILPTIESQGASIPNDVDFVQGKLETMQHALENDANEIDQLRSLVTRDAAEAQVAFRAIDTLKLPLQYQTTGGGGWWSQDQKVADRSLRSTRKNTLALPDDVEGDPATVKSVNGVPVNLVDYFSQRSDEMGSVLDRYKGNLKEIEDHLHGVELSLNRQINEFVSKSRDGASAGTPKSVVNDLAAVLGDVEAGIMGVAARLGGVSEQVQEMTLGPLSVESRYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URH4</accession>
    <name>A0A1Q5URH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-asparaginase II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URH4"/>
    <dbReference type="OrthoDB" id="2588474at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110:SF1">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="38864" checksum="2B7F4BE94E9436E8" modified="2017-04-12" version="1">MRTLFSTDCVITDRAGVVENRHGVHAAIVDARGRLLFAVGDPARITLVRSAAKPAQALAIVETGALQKFNLDDADLALMCASHNSEDRHVSRARSILSTIQCREEDLQCGGHPAVSDVVNRSWIKADFTPTAVYSNCSGKHAGMLAGTKALGADVGTYHLPTNPMQVRVREAVDEICHLEANGSLWGIDGCNLPAPAFPLHCLARMYAVFADGASQAVSNYSGTTPRTQALSQIFHAMSTYPELVAGDDRFCTVLMRAFQGLLIGKLGAAGCYGIGIKQTDRTRELGADGGLGIAVKIEDGNIEILYSAITEIVEQLQIGELEMRQQLSRFHCPDIKNTVGIVTGKTYHAFKVRAVGDNDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URW5</accession>
    <name>A0A1Q5URW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_1437</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="15">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="13">
        <location>
            <begin position="246"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="14">
        <location>
            <begin position="537"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="881" mass="98679" checksum="4B7402E7E296A299" modified="2017-04-12" version="1">MCSSRRDEPSGSTNVQGREVLPTNVKPVHYDLTLEPDFKTFKYNGTVTIDLQVNEDTDFISLNSNEIDIHSATVRSNGAVIESKPEIIVNKDTQVATVQFKQAIAAGADAQLTLTFTGTLNDNMAGFYRSSYRKDGKTEYIASTQMEPTDCRRAFPCFDEPALKAKFTVTLIADKDMTCLSNMDVASETDVQDGSKKAVKFNTSPVMSTYLVAFIVGHLNYIETKNFRVPIRVYATPDQDIEHGRFSLELAAKTLAFYEKAFDSDFPLPKMDMVAVPDFSAGAMENWGLITYRIVDVLLDEKTSGASRKERIAETVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNVFYPEWKVWQTYVIDNLQSALSLDSLRSSHPIEVPVKRADEVNQIFDAISYSKGSSVLRMISKYLGEDVFLQGVRAYIKKHAYGNTETGDLWSALADASGKPVQSVMDIWTKNVGFPVISVTENPASSSISLKQNRFLRTGDVRPEEDQTLYPCMLGLRTKEGVDESTMLTEREAEFKVPDLDFFKVNADHSGIYRTSYSPERLTKLGQAAKDGLLTTEDRAGLIADSGALASSGYQKTSGLLSLLKGLDTETEFIVWNEMLTRIGVVRASWVFEDKQTKDALTAFQRELVSAKTHELGWEFSEKDGHILQQLKALMFGCAGSAGDPVVVKAAQDMFARFAAGDHSAIHPNIRGNVFSIVLKFGGAKEYDVILKRFREAATSDEKTTALRCLGVAEEPALVQRTLELAMSEEVRSQDIYMPLAGLRNHVTGIDARWTWLKENWDAIYKRLPPGLGMLGTVVQLSSSSFCTEAQLKEVEEFFGAKDTKGYDRAVSQSLDAIRAKINWLQRDREDVENWLKNNQYFQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URY3</accession>
    <name>A0A1Q5URY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000013">
        <property type="protein sequence ID" value="OKP15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URY3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="18897" checksum="FF9F91D8CD59CC30" modified="2017-04-12" version="1">MSNGKYRKLADTPSFAYWASNSPQSILAGILNATGGNGQSGLFFKSKTRFLHGPLEEVFSSSFTRLTFVYPDGPTSGQDFLENTGMNDPSEAQQNDCEEEQGQDWRLWAYGDPDGRSVGFERSLRHIVDVLHREGPFIGVIGFSVGAALASMIAALLEDKRVDGLDLMVIPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMN7</accession>
    <name>A0A1Q5SMN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39510" checksum="3A9CF48EEB43A728" modified="2017-04-12" version="1">MSSYQPWGGFILNEIGIGEARICCGTTKTGATCKNSIKIQDIKAGQQQLANLAARPLDFPTLRPILCDIAKNFLCARWHRQRQANQVGQQWYEAVARNPEQAGHISEDASVAFDTDASQSQRPTLTSPSESEIPRRVTRQNEERQMPPGRDSVPLEPLERTVRYVTASMLRTDSVPWCISSAEPATLSGLNIGVGMQHLELHSLTRSDELSHIHCPFCLGDDEDQADESVILRCKQCRGLAHLGCVEEWLEKREVASNVSCCTCRRDDALDALLSPPRTITTNPDIDVENTRVHVSPVAEETNTIRNARRAGSARLPAQSGSSGRRSTMSGAGRSIRRSARLANTTPSLRRSSRLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQU4</accession>
    <name>A0A1Q5SQU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQU4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQU4"/>
    <dbReference type="OrthoDB" id="4719016at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="255" mass="29459" checksum="58BD282C44F926C8" modified="2017-04-12" version="1">MSPTVMKNVSMAHRLGSSREEAKDNQEFATANEVGHFFQKLLWVAGQELENPTSASSEALKSFLESINKNNRASLRGFLRNSSLSTGPESAYKEFKRRYEPMDVNQVLYIIDEEFLVREARIVTTPDRPQTSAEKIRIIMSTILWMDNLFPSCEGMVWKMRFISFPIFSLKESLDWLRKVRQRGFLTGHQLSDHDKNILNKLWNWFDTHDQRPVKLAFAMASHGMVRDVLNERGQLSHIIDDLNKLIGMPVRLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRF7</accession>
    <name>A0A1Q5SRF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalate decarboxylase OxdC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRF7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202768" evidence="5">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="119"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="291"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO90543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="453" mass="51017" checksum="B0C11BC7B79F4EF3" modified="2017-04-12" version="1">MHIRSPSFAALVHMGLLLGALASPAPDHALQQLMQVPPRNRQDVFGSPPFTPGHQDPFDHKIDSVGEGREPLPFRNGEGATVQGPRNKDRERQNPDLVRPPSTDHGSMSNMRWSFSDSHTRIEEGGWTRQTTIRELPTSRELAGVNMRLDEGVIRELHWHTEAEWAYVLAGRVRVTALDPDGGSFMDDLEAGDLWYFPAGHPHSLQGLSPNGTEFLLIFDNGHFSEESTFLLTDWMAHTSKSVLAENFRLSPDKFKSIPTSEKYIFKGSMPDSIEKEKPRGFRKSKLQFTHHMHAQDPIRTSGGQVRISDSTNFPISKTVAAAHLEIEPGALREMHWHPNADEWSYFKKGRARVTIFAAEGNARTFDYMAGDVGIVPRNMGHFIENLSDDEPLEVLELFRADKFQDFSLFQWLGETPRRMVAEHIFASDPDAAEAFLKQIEGAEKDPIKDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUH4</accession>
    <name>A0A1Q5SUH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUH4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO91667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="190" mass="21423" checksum="1591A49F315FA2DA" modified="2017-04-12" version="1">MNLDDIPGPCHSSLRIFKQSSPSASLNPRVLLAMQLPTTDRADQRKLSAIETPMSTWRGFIRRFAPSWFAIVMGTGIISILLYKLPYNGAWLYWISVAIFVINVTLFAIFSLTSALRYICYPILWRAMITHPVESLFVATFPMSVGIIAQGIVNICVPAWGSWAATLAWVLWWIEAVTSVVICFYIPFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVE4</accession>
    <name>A0A1Q5SVE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARCA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVE4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVE4"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO91866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59000" checksum="FBF92D845B9F69A4" modified="2017-04-12" version="1">MVEDAANSSHPSSPYTGDISLETTGADHDTQVSETPLAISRLADTQAAEPGPTQPTVSPSYTLHGSISSHFSPIEGPSPRESHHSVRVQAILLRYYTEEIAHRFDLCDPEYHFTNAVPQRARSCRPLLNAILTTSARHLCGLARYRKQDGTIEWQGHILPELSQESPVHYHNECIRDLLELSLDPEQVHNENLLAAAVILRTDEEMNGPLSYGDEDSEVFLRMLNIFIDAQIPSTQVPTHHSPLARAFHSDFHSPAMSQSTSPEYPAVSSTPGHTIFQAGDDTISLRRAVFAVALRQELFTSFMKQRSLHFQLSHYESFRDLLPAQDAVWAHRAVVFCADVFEYCYGSRSASEIYHFHHSGIQRWQQLQRYERKFSSSLPPSFEPIHCRLADPSCGEVFPEIWHLNTYHRTGTAHLELARILLAVFDPTRPRLGPGSMTSHRELGRRLREIVLRLCGIAMCNRKSPPAFIEALMGISTCGEYFELPREQEALLEVLRIIQEEQAYSTLKVRNALERAWSASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYI3</accession>
    <name>A0A1Q5SYI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000726">
        <property type="protein sequence ID" value="OKO93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21418" checksum="B90C68D6E5EE43F0" modified="2017-04-12" version="1">MAPGNASNAPEDNGTGSDRQTTLARSGEAVARNAEQAGYISEDASVAFDTDASQSQRPTLTSPSESEIPRRVTRQNEGIIPPVRDSVPVGPLERTVRYVTASMLRTDSVPWCISSAEPATLSGFNIGAGMQNLELHSLTRSDEVSYIHCLFCLGDDEDQADESVILRCKQCRGLAHLGCVEEWLEKREVASNVSCCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ89</accession>
    <name>A0A1Q5SZ89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Crh-like protein</fullName>
            <ecNumber evidence="18">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PENSUB_12346</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ89"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012298862" description="Crh-like protein" evidence="22">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="23">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="254"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OKO93283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="424" mass="42918" checksum="232A592A3BA068FD" modified="2017-04-12" version="1">MPSLFKYAAVALAAAAPFASAQTYTDCNPLQKTCPADAGTTESKLNFDFTQSSGLNKWKTVAGSVSTGSNGAVFTVAKKGDAPTIETDFYIFYGEISVTMQAAPGTGIVSSIVFESDDLDEIDWEALGGNTAQIETNYFGKGDTTTYNRDTWPAVANPQSTFHTYTVNWQKDKTVWSIDGTPVRTLNYADAQGGARYPQTPMRVRIGIWAGGDPSNGQGTIDWAGGKTDYSQAPFSMYVKSVSITNANPADSYTYSDTSGSSDSIKLSGAGSLSQTSSSSSSSSSTSSTSSTSSTSSTSSTSSSTSSQSTESSTTAHTTLATTTHTSTAKTTTAGSTTASSTGATTSGSASGSGSSTTPSGSSTQSGSSSSTGSGSGTTSGSGSGSASGTAPKASATFNAAANVVANYLAPISLLGLVTAFFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZV7</accession>
    <name>A0A1Q5SZV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoglucanase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZV7"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013225408" evidence="6">
        <location>
            <begin position="26"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="384"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="48144" checksum="FBEE96E55B75DC2F" modified="2017-04-12" version="1">MSFSKIAGVVLGSAALVAGHGYVSGAVVDGTYYGGYLVTQYPYTSSPPETIGWSETATDLGFVDGSSYASSDIICHKGAKNAAISAPVKAGGSVELQWSEWPESHHGPVITYLANCNGDCSSVDKTTLKFFKIDEAGLIDDSSVPGTWASDNLISNNNSRTITIPSTIEAGNYVLRHEIIALHSAGNTDGAQNYPQCFNLKVTGGGSDSPAGTLGTALYKDTDPGIKVNIYQSLSSYTIPGPALYTGAASSSGSTTTAASVAATTTAAASETTTAASSTVASVGVISSASPVSVTPSATPIRSPSFSIPHSNSTRVCRPSSTGRRPGHGHSAGPTGRPQPSGGENQASTVTDYATATATATATAQLTDSPNVQTPSADDTVTVTASAGGQSAASSTPAAGSSDSSSSSGSSSSGSTSTGSSSGSSSSGSSTSASSSYNSSDWSSYLSSLSAEQFLNMLRQTLKWLVSDKKVHARDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1A8</accession>
    <name>A0A1Q5T1A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1A8"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="25647" checksum="275CD18F98ED4186" modified="2017-04-12" version="1">MGPINNSNHDLNTTSFLNLPPELRLKIYEYALTVPNDYIDKPLIVINDRGNVFTVRNRYKALSMCPSWVGEDGTARNILAVYHQIHDEAENYLYSHHTLFFRNSFDLVRLGDFLDTLSPTARGCIRSVGFEVYLFVHTQMGVPKRTLKQYERAARLLSVKLPEWNNVLFYLDPRFYYPAAAAGCREPAARGVLDLAAKFGPLCRDITFYPLSTSDYRLLWEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2I3</accession>
    <name>A0A1Q5T2I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2I3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2I3"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58558" checksum="E072302823CD545E" modified="2017-04-12" version="1">MTETTVRLHITPLTPDILPAVLPPSLRQTATDISFHTIPTFPENSYGYITLPIMDAEKIKKKLNGSILKGKKFKVEAARPSKRERDAEDVDAGAEEKKEKKKSKKRKSEEQEDGVLEGYELPSDRKVKRGWTEPSKKDRRRAEKSKSKGDKKEKPQAKSKYTEKEECLFRATIPPNRKSLDAADEKKAKKAKKSTDNVVHEFAKATTYPSFLRTSGENAVPTTEFDEGKGWVDASGKVKEAASDKARKHDYHPGQKAGAKVKKSEVQKMLVKKKSPEPSSESEDYTSSSGPSSDESADSESEADSSSDDSSDSSDDEADEKPEPTKQTAKAAPATENAIEDAPEESDLDPDAEMADEPAKEAEEPSTQEVHPLEALFKRPAPTSTEEIAAPAPAAGFSFFGGDDIESEDEPQSAEPQTPFTPFTKKDLQVRGLRSAAPTPDTTMVNRRMNWIEADDVEDDEEEFSVDTPVSKAREKEGPKEETEFTKWFWENRGENNRAWKKRRRDAAKEQRQRDNRKKGMKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T389</accession>
    <name>A0A1Q5T389_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 78, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T389"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T389"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="120"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="519"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="697"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="333"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="798" mass="88330" checksum="2C8EBE488F09C256" modified="2017-04-12" version="1">MAARLALNSRTRLLRTPNLPTSSRLLSTTTRSAHLPRILAPLLTSAARTTSVTSVRHYANGRPHPPGGTHRMNMSPEPEKPALEQFGVDLTEKAKAGKLDPVIGRDAEIHRTIQVLSRRTKNNPVLIGAAGTGKTAVLEGLAQRIVQGDVPESIKNKRVISLDLGSLIAGAKFRGDFEERLKSVLKEVEDAEGKVILFIDELHTLLGLGKAEGSIDASNLLKPALSRGELQCCGATTLNEYRLIEKDVALARRFQPILVGEPSVASTISILRGIKNKYEVHHGVRITDGALVAAATYSNRYITDRFLPDKAIDLVDEAASALRLQQESKPDAIRELERDITTIQIELESLRKETDVSSRERRDKLQEDLKIKQDEVGKLTEVWEKEKAEIDTIKRTKEDLEKARFELEQAQREGNFAKAGELRYSTIPGLEAKLPKEGSEQEAEKQSLIHDSVTADDIGNVVSRTTGIPVNKLMAGEVEKLIHMEDTLRQSVRGQDEALAAVANAVRMQRAGLSGENRPLASFMFLGPTGVGKTELCKKMAEFLFSTETAVVRFDMSEFQEKHTISRLIGSPAGYVGYDDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGFLTDAQGHKVDFRNTLIVLTSNLGAEILVGADPLHAYKDTGGAEVPSDIKKAVMDVVQNAYPPEFLNRMDEFIIFKRLSKEALRDIVDIRLKELQGRLDSRRMTLQVDNEIKDWLCEKGYDPKFGARPLNRLIAKEIGNRLADKIIRGEVTSGQTVRVSLNEDKSTLVVSAEGKVEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q1</accession>
    <name>A0A1Q5T4Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="60427" checksum="0503C470FE95F3D3" modified="2017-04-12" version="1">MPYMSTSSLQELQARVLEIFWARYHCLVPIVTRDDFADHEPGGRLGPLQEALIAYCLQSIYYSGLHHRLLGVRLGLTETEDRPAGKQQSPVVTLFVASFQKALAANNHYLLYAEPSLRDIQRHILMALFLLNSGEFLAAYNITGVAIRLAQSLSLQRPPEPHVSIQEAEIRGRIWWMLVHLDFHCSRYLGKPMIACLRETTVALPNPTSGSELSSSEPAFYSASILLTVEAKKTAESMAVRQDAMCGNDRGRTLELCAEYLSQEITRVYQWRDQMLCTEPFTYMKLACRTYNPQTRGVTDGPNSDSDAHIYHQSPVHTLQQTLLELQYHDVVIWFHQSFIQFPSRGLVPQRSPRADIHATTALQYALTVTDLIHSRMLNHDALYGCSDVYQYVWNAALTLIGFMLAYPLCHWFPIARQHLEISLQIFEAGKISNPIACRAARLTEYLLGRVTVLMELLNSQPPLNDHNGPATTGYRGPETRDPVEYEKQFTNPLLHDSGCDALWSWADMVDPQTWDGYCDEIIDVLTDLPEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6K2</accession>
    <name>A0A1Q5T6K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6K2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6K2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012705273" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="732" mass="78965" checksum="4801D0578ADCFB1E" modified="2017-04-12" version="1">MRSTIWALLGLGVVLPQALAADTLSTSGFSLCMQDSAINVQKLDVTYTKSTKLVVFDLAGTNSKEQNVTATLTVTAYGNQIYTKTFEPCGTEVHVAELCPVPSGAFSASGSINVPDEYASQIPSIAFNIPDLDGQAKLTLTSDGKSVACVESQLSNGKSASVKGVAWASAGIAAGALALSGLSALGSAGSTGAPASSPSAGDVMGWFGSMAMNGMLSVNHPAVYKSFTKNFAWSTGLIPWASMQNSIDDFRKATGGNTTHNSYIYLTGLSTASSNGTSAKRSLDFLYRAAGLVARSVDVSESSTNSTSNSTSSSSSGLTDCGSLNFSTLKCYGEEVMIPSANIFMTVLLVFAIVVAVVVVGILLLKVILELWALYGSFPKKLSNFREDYWGIMARTITNMILVLYSIWVLYCVYQLRNGDSWAAKVLAAVTLSVFTALLAFFAWRIVYLARKYKKTEGDTTALYENRETWRKYSLFYDSYKKDLWWLFIPVIVYALAKGCIIAGAEGHGMVQTIGQLVIECCMLALLLWNRPYATKSSMGINMTIQIVRVLSVACVLVFVEELGLSQTTKTVTGIVLIVVQSGLTGVLAILIAINAIIVCIRENPHAKKLREAGMCRPCKLQAQPPVHLLTVSPSLENANKDLDDLTPLDARESLLIDHPPKRDFTEMSKFNFNAPYEAYRDHPVHRPNSNSSNDRLVYADYGVAHGRSHSQESRSSIEGRKPTAPGYGMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T7Y1</accession>
    <name>A0A1Q5T7Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T7Y1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T7Y1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="175" mass="19644" checksum="33AB8FCBC55812A8" modified="2017-04-12" version="1">MPSMTFQSDPPEQPGPRTRRSSKMSETSNEVRPWRAKNLERNRIFANKCRMKKKKNHKSMQALLNTETSKRDSLLSELGRLKDELWYLKNMIFEHANCEHQGINSELAKMTQRILESSSGQLKCPSLAFSTSTCSDGSIRGEPSGREHVTLPIGVVSYGASPEAIFEDSLGLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8U4</accession>
    <name>A0A1Q5T8U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 13">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_10811</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 13"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8U4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8U4"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO96636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="431" mass="47820" checksum="45B0F77EA280704E" modified="2017-04-12" version="1">MEDSSNTSGSQMRQPKKRFVGRRTAETQAQKDSTGQNDVESTAVQTAAPRRTPRTLNQVPSEILNDPEIQAAIDLLPKNYSFEIPKTIHRVRSSGAKRVALQFPEGLLIFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYIFVDISIDTSHLIATLERNFKPGQTIATVGTIQFNATLHGLKSVLERAGFRVVIPQIMPLSKGEILGCTSPQLPESEIDVLLYLGDGRFHLESAMIHNPTIPAYRYDPYSRTLTRESYDHEEMHTIRRDAIATAKTAKKWGIILGSLGRQGNPNTMAMIERHLAERGIPVVNLLLSEIFPGKLASMSDVECWVQIACPRLSIDWGYAFSRPLLTPYEALIALGVRENWDKANKGVYPMDFYAKEGLGRTKPEQPITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAV8</accession>
    <name>A0A1Q5TAV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAV8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="536"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="807" mass="90085" checksum="E963C69F1B002FBB" modified="2017-04-12" version="1">MAEELARLTSEVERVVTAPYVPSLQYHPACIALLSSPLPPDFVPPARLAGFITKLVSAMSATPGAETIAPLYALMTGLKGSPNFINEVPTDVMSNLQLEFTKTLRNLDDHMGNLLGLATFAQISMSHRSQLSRHPGVYDESVVYELLRFTVDVLKDDSMGHDSMVNLHVSDLLLSGFQANLSQPMIQTLLSSASTKQAIASLFARFPLLPSQLQCQDAQVCYCACSALQNRVLLNLFEIYFAAALSHSGDTTDIAIMKSFVERTTKSFGKSDCTFARTEHNAYRSSMYLRNRQEFNSKRQPIRDWRSAITEFHMQNAETSHNLLMKKVDDICFDLERRCYDIEGPVRSAEEERDKHKYDAEQLRQQNEDLARQLNQSTQAVSTLQQDLTRLEKHAGLASARAEELSEALELSRQELRDQQHHSDDALRAEQEKARSRELELIATSTEKDDQLEELQESMRQLESQNQLLQQVVETSSHERATSAETNEALGHEISEVRNLLEAKTLFCCQKEDEVKRLLAENNDLQTELGSVQTIIDDQAREIEQLHATLQGVEEKAKTDMLIFNRDKEAEIAKLASEISTQKEVNGRLQKAMQTAASDAAKELQSKDKRIHQLEKKIQSLRDERAAKAREFSEAQQHIGRLMNVMGFSAKSNEKSSSKSQRSRDAIIAPTPSRRQSAVYDDDDDIQLAESFEYLASNLQGPTPKRPKGNGRSIHPLQAPAPKTPAAKNSVTSTNAPKTGLRQPLIEAGTNSPVKSQASLGSKGSQYDSASAGNMGENRLQDLDLDMDLEFSKDFLFTSTAFSPSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC11</accession>
    <name>A0A1Q5TC11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_9695</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC11"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC11"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000230">
        <property type="entry name" value="Putative dihydrouridine synthase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="20">
        <location>
            <begin position="536"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="486"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO97769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="625" mass="70386" checksum="70B6B682D0B9DBD3" modified="2017-04-12" version="1">MASDSAPQNGAAEVSVATPNKKLQGRQFYESIGSPKYIVAPMVDRSEFAWRMLTRSFMPADEPKPLLAYSPMYHARLFGEQPKMRTQHFQPTREANGDMKRKDELFLDGNPKFDRPLFVQFCANDPTEFLEAARHVAPYCDAVDLNLGCPQGIARKGHYGAFLQEDWDLIYKLINRLHTELSIPITAKFRIQETKEKTLEYAKMILSAGANIITVHGRRREQKGHETGVADWSYIRYLRDNLPPETVIFANGNILNHEDIERCLEATGADGVMSAEGNLSDPTIFSKAPPPGSEGREYWRGRDGKGGYRIDAILRRYLDIIYEYVLEQPIPERKPLYLPSDPIDEAEKAKEEEQDEEADGPPRKKQKREKLKRTNSPSLGVMQGHLFQVLRPMISSHTNVRDALARARPGDMAAFENVLSLVEKAVKTGLQEYEVSPEKFEKQPDVTLTGSKATIAEYGRPFWVCQPHVRPLPEEALVNGALTAKGKNTVPKDSAEKKDKEATGTEAVAVEGVSSATNGDATNGDATNGDAKNGGTTSDILNRINWDSKFSRDDYIIGFVDRFEGQLEVSMNSWKKETTDEEFIPQHRVLYIRHVSGEIVWDRRRRIDKIFNSGNSAFSELAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCF5</accession>
    <name>A0A1Q5TCF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCF5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="208" mass="24455" checksum="6C61E7BD15B4E6D9" modified="2017-04-12" version="1">MLRRAKKLQPIFDTFCSEFHHTHLRVTSDKWRQIDYLICITQPFYKFTTALSKTKDVTIHTVFSIYNRLFDHLENRIRQLQRKKIGWKQQMLKALRSAESKLRDYYTITDLEGLSDIYSTGTILAPQYKLEFFQTPDWQDNKKDFAARYKQSLEDRVKHYEDSVYSSLSRAGGIQSAKPTSEIDLLLARDSRPTAPVSELTQYLKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCF6</accession>
    <name>A0A1Q5TCF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="96" mass="10762" checksum="E9A1FD96ED652E43" modified="2017-04-12" version="1">MYALQRLLYGFPEPAPYKRSKPVEVLCLGLPHTGTESLSVALRTLGLPTYHGWDLVFELDGSKLLHCTELVRRTYNGARDGDVQTTKQDASLQTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD65</accession>
    <name>A0A1Q5TD65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD65"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="16564" checksum="D0957F222951C563" modified="2017-04-12" version="1">MSRLPPKVQQVLDFLVAEQVPGSQTFQYPVLASTSLDRQHIKLRKTEIAVLFMEIIRLCSLDMEVPFWLWYSIYHICCNLRRDTRDRIELLPFSPEVAPATALHTLENNGIGEVFRPTCVPIYLDHYPLRGVLTMLRKCYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDB1</accession>
    <name>A0A1Q5TDB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA repair protein rhp41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDB1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDB1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.20.110:FF:000003">
        <property type="entry name" value="Putative DNA repair protein Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="522"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="584"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="649"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="836"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="964"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="977" mass="108966" checksum="BEDAB2075F8EEA14" modified="2017-04-12" version="1">MARQSAARPARGRAPRGRRPNLETPREDQIPEVYQEMLEEAEARDPGQFRSDRPIKRRKLGDTKFSQTRAIPVDPPQLEQSNVAPPSETDDFQNVQTIYDSTTSDESDVEWEDVDVAQPAHGLFGTADGSEGRDETLQITLDRGSEARKKAPPRRKPVTAAEKKLRLDAHKAHLLCLLAHVNSRNRWCNDDTVQVCLDFAENSVGILMGKQRNLKRMLPRKIIALLNPDEDKPQFTRSTTFIDGLNQAGDIFSRRFRVTKPGLKRAHWAEDQEQLKQRMESIMADGEIFFSKEDFQYQAKILQGSRDFGAQLFCALLRSAAVEARLVCSLQPLPFSGTVKDMTPSKKPSQYIVISSDDHETSTDEQQKSPSGLTTPSRTRRIGRPGFTSRPAQTSVRLGSQPVARESSYPVFWVEAFNEAVQKWIPIDPLVTKSLAKPSKFEPPASDPYNNMSYVVAFEDDASARDITRRYTKAFNAKTRKSRVEITRNGEKWWNDALIAYEKPFLEDRDEAEISELTSKSAAEPMPRNIQDFKDHPVYALERHLRRNEVIFPKRVIGHVGLSKTTSKSDNLETVYRRSDVHLVRSADKWYRLGRDVKVGEQPLKRVPATRPKSGFASDEDDDEAEETPLYAEYQTEIYRPPPVVQGRIPKNAYGNLDIYVPSMVPPGAVHIKHPEAARSAKILGIDYADAVTGFEFRGRRGTAVFGGIVIAQEYQEALHEVLRSIADERRQAAVEARAAEALRLWRLFLIKVRIAERVKVYADEDEKMDYADEPEIPENDMDYDEEAGGGFIPEEGGGFVPEDAGGFFADNAGGFVPEENQVVTYEGGGFVPDEPGEGEGFILDEPTEDPPAPVPEPSITTQLSATFQRNRRSKAPKAPRYELIVVPNKSEPGSEGHQQASPLEGSSAMAPIAVDSSANGGSKSASVDILSRPPSPTEATQPSPSPPAPDSDSEIEKGSLLSEDPEDEDAIPEWLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE02</accession>
    <name>A0A1Q5TE02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_9119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE02"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE02"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO98443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="15392" checksum="7219B49C67F43C8F" modified="2017-04-12" version="1">MPASVHSEDAQEHDQSMMDVEAEEPVNPILLDEKRIVVLPGSTETSASFQFDGEGHTMGNALRYSIMKNPAVEFCGYTIPHPSDAKMHVRIQTNDTTTALEALEKGFNDLMDLCDVVTEKFTAARDQFKEDQVNRMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEH9</accession>
    <name>A0A1Q5TEH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEH9"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21308" checksum="8B63F22EFE0C24F0" modified="2017-04-12" version="1">MSPFKFVNSTAPVPGNGGPPPSEFTINAPSSTDIWAKPPSTTRFSAPILYQSMPLQSFKRIRVAINAQWKYLYDQGGLIIVLRNADGSHKWVKAGIELTHGKPHLGVVAKDRWADWSLLPVPSGGGAATIEMVKEADGSLWIYLVEGVQKSPIREVTWVFEEDGIEEAWVGVYAARPGGEGGELPVNFGHLIVDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH11</accession>
    <name>A0A1Q5TH11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH11"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH11"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="27645" checksum="CFDF7A88DFDF2767" modified="2017-04-12" version="1">MSEQILAGKTCLVTGGAGGLGKAIATHFLGAGANVVICDINEERLQEASAELSSKGPLRAIKADITKVEEVQSLFDELIREFGKIDVLVNNAGIMDHFAPVGDLDVEQWERVMALNLTAPMILSKMAVRNMLEQPKPDGRIINIVSVAGRAGWAAGAAYTASKHGLVGLTKNTAAFYGNKGIRCNAMMMGAMNTNIADVFKTGMHMEGYKKMNSVYESIQAPPCDLDEVAGFCVNLTYGKGASVINGACIAIDNGWTCVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THZ5</accession>
    <name>A0A1Q5THZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THZ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THZ5"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="56377" checksum="47BC340493DCB794" modified="2017-04-12" version="1">MSVLFTSISEDNPVKPGDAEALLEPLGLTIDPSESSDFHTLLAAVHDCAEGVAALPDYQPSPDQTKYPRENVRRPSKEEQVLGQAWAHKFLIRGNEEGGVLAGKSVSLKDVIAVAGVPQLMGSDIIPSWTPTTDATVVTRLLDAGADIHGTSTCENYCHSTSSFTSAHGTVENPHATGYSAGGSTSGGAALVAAGLVDITIGGDQGGSIRVPASFCGCVGLKPTYGRVPFTGISSGDAVNDHAGPLSRSVLEAAICLDVISGYDGIDDRSLGSAKPGSTTFAANLSQGSKRLEGVRIGILKEGFGHSAVSSSVRHSVLTAVKRFQGLGATIEEVSLPDHLHGPAVWTIQQRIAGSQTLLGQNTGRRGLHTTEMEHARLPWTDDGFQRAFPSTKNVIINGLYLMSRFPGLYGKTTNIGRQLSDKYQALFEKYDVLVMPTTPVVAPKNGKRGLPLESLKPSMGLTINTAIFNVTGHPAISIPIGFASAPGDADIMLPVGMQVVGGLWQEEKILRVAHAWESNFDWKKMLFSTNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI17</accession>
    <name>A0A1Q5TI17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein RTA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI17"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="285" mass="32246" checksum="83C6A3FAAA35C443" modified="2017-04-12" version="1">MAVLEPYKGGYYLWKYIPSLAAAVIFLLLFIVATGYHSWKLHKTKARFCIAFVIGGIFEIIGYVARAAAHNQTGKLMPYSIQSVFLLLGPTLFAASVYMALGRIIRCVRAEKYSLIRINWLTKVFVMGDVLSFMVQGGASGLMVSGNTAKLGSNIVVAGLVIQVLMFCFFIVTSVMFQVRMNRCPTPESFDERFKWKSHLRVLHAISLLILIRSLFRVVEYVQGNDGYSLTHEWTLYVFDSTLMFVVMLIWGIWYPGNLQVLLKENMPLTSLMSRDVESRQGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIB8</accession>
    <name>A0A1Q5TIB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_8180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIB8"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="188"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO99963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="643" mass="68801" checksum="7FCAC92D145AD066" modified="2017-04-12" version="1">MEAMLQQSRAMCPFLKRTAPTTLRTLSTATRPSTGGGTMSNLQVLARRCPVMSKALAVQSARMSGTKRFTSSAAGIPAMKPMRAPTAGKRALHTTGGHPASLAPGTYEKTEQVHPNIANTIRSTPATEAAVRGPRPAAPITSRFDYDAFYNGELEKKHKDKSYRYFNNINRLAKEFPRAHTASAEERVTVWCSNDYLGMGRNPQVLESMHRTLDTYGAGAGGTRNISGHNKHAVALEDTLAKLHGKEAALVFSSCFVANDATLATLGSKMPDCVILSDSLNHASMIQGIRHSGAKKMVFKHNDLQDLEAKLASLPLNVPKIIAFESVYSMCGSIAPIEAICDLAEKYGAITFLDEVHAVGMYGPHGAGVAEHLDYDVYASQDTTNPKSTKGTVMDRIDIITGTLGKAYGCVGGYIAASANLVDTVRSLAPGFIFTTSLPPATMAGADTAIQYQAQQPRDRVLQQLHTRAVKSALKELDIPVIPNPSHIVPLLVGDAELAKRASDKLLEEHGIYVQAINYPTVPRGEERLRITPTPGHVKPLRDHLVQAVQAVWNDLGIKRASDWQSIGGFVGVGVEGAEDANQPIWENSQLGVDASEPLESSITRELSAEAAEKAAFPAMKTATPLGSNVHSAIASTPVGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJH8</accession>
    <name>A0A1Q5TJH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJH8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="161" mass="18249" checksum="CBA9DC47CAE66309" modified="2017-04-12" version="1">MLRWVYPVRLIQALFAFAIIGLTAYIIASLYDEWSFSNVIYFMLFNGCWTIVVAVPYLGLAPLWLPRFSHEFVIPAMEFVTMALWLSGWIAMAAMIPKPDVCNYASCHALQATIVIAAVEWALFAFTNVYAFMDVANSRRNHHNHEQQQPAVSEVTAPESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJL3</accession>
    <name>A0A1Q5TJL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein Atg28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJL3"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50943" checksum="C740293F47F6535B" modified="2017-04-12" version="1">MSTLLPFRDKRLPPVPAATSMYHHDPLLQVERQTKYIQRNLQTLIDAQSEGLLAGLARSQPEDISEGSFTPTSSAAGRARSPSTTPARQPSVKKIGLRAARQGIFLSIYDLLKLREEERDILLSQTDERDNALREIEGFTSRKDGLEEAISSIHNDRENQQAKQLQEEARGLETDIRELETKLYEMKAKHRNLISKISNIENSVDAKLSSYTESLSLLQSDIQSYLRDPPVQPLPRRSSESSFYSLNPKRRTLDMAEEHWKLERERLHKRQHEVDAEILALEEGGGVWKQAVADVSGFEKRLRANMRHYIEIQSSATDSNNAQLSETMAEVATNVSDDLDKTIQRLETHLELAEKKDWKLLVCCIAAELEALREARGMLLPAFGLPVHDDAPPSQSPSSSEGQVSEEASDVHEHSSDNDDSEPPADLFKDEQAHHTDNASRSEDDEPDPAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL65</accession>
    <name>A0A1Q5TL65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein GLC8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL65"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33246" checksum="7648F13BD7D86CE3" modified="2017-04-12" version="1">MTTAPHLPAKAHSTDDVHPRPKGILKNSKSFQSAPVPAPAAVPPAIPSIAEPEDTKELTLQNTLVNAGRRRSSSAANPGSSSRRQSLASQHDDNQPRLQWDEANLYLTEQERTAKMKIDEPKTPYAPHYDPAEDEEELRLAESRGSLIDAQDVVVDELDKTTHGDHHKKGVSEDDIPDLELGEAEEGLSGLGQETPEQRIYRERSMSVESHKSDKHVVVEPDINGDAPASGDDLMTTEEAKEKHRQFEEHRKKHYEMRNIKELLAHPEEEEDEMEEDEDMTEPSVPQIPSQFRNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMA0</accession>
    <name>A0A1Q5TMA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC93-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMA0"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF56">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP01349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="469" mass="50814" checksum="5A17F086E3ADE72B" modified="2017-04-12" version="1">MAATNSHPEVVDEHEARSVVESTQPSTRRSIFRSIPFQIAVASAVSFTAPGMWDALNNLGAGGAAEPYAVSAANALVYGLFAIVCVAAGAINNRIGLRYGLTLGAIGYPIYGAGLYTNNNSANTWFMLFGSALCGISAGFFWAAEAAIIIGYPSPHERAFYLAIWQTAKAAGPIVGGAINLGLNAQTSTTGSVSSSTYIVFIVIMCLGFPIALLLSPAEKVQRKDRTLVLVHKQASWAAEFKAALSLIATRRVLLLLPSFFISYFYNGFLSTWLTTYFTVRARAFSSFFTNFAGIASSFIIAGLLDRQGIHIKTRAKIAFISIVTILTGTWIWASILQNQFYSAPESPVFDWFTGGFGKSYALVFFWTFGGQAFQQFLYWLIGQYSTDISSLSYHCGILRGFEALGQTVAWAMQSEGGANHFVSIGLNFGITLLAVVPTWIVLSELEHSHEVQVTAEDVNSKIQDENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TME5</accession>
    <name>A0A1Q5TME5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_7387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TME5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TME5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP01397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="461" mass="50733" checksum="04BC47D132357392" modified="2017-04-12" version="1">MSSNQWLRDSVHLAWVDSDPANAAVTESTDIKSIKDAAKTATQGMMVWYHGSEPGQIPGAFPSKWWEGSALFYALLNYWHFTGDTTYNDQLSLGLQWQSGTNGDYLPSNYSHFLGNDDQVFWGLAAMTAAELKFPDVSNGFSWLSLAQGVFNSQKGRWETSMCGGGLTWQMFPYQGTGYTMKNAISNGGFFQLAARLARYTENQEYKDWANKIWDWSVNTPLVNNKTWVVQDSTEGTENCKDGANIPWTYNYGTYLMGAAYMYNSTEDSKWLDATNGLLNMTLQTFFQKESGYVMEDITCEPREICNNNEVLFKGLLSTWLSYVALVVPKTYDLIMPKLQTSAIAAAKSCTGNNNNTCGVQWYKSQWDGWTGMEEQISVSQVFSANLLPFVAEKAAVAPVTSNTGGNSSSNPNAGLDSNKEGDTPKPITTGDKAGAGILTLVLVGFWAALMAFAIMGSSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMH7</accession>
    <name>A0A1Q5TMH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMH7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="11380" checksum="A9996E0FA98BD714" modified="2017-04-12" version="1">MSACAFIYFSFLKEICKWDSLSLYSVLRLFLSYPVVQIRVPTARRSRQVKEKSWNKWEQDKERRKDYGGSLSDGMRESEVYNFEKQNGGGTAQTHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQM7</accession>
    <name>A0A1Q5TQM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQM7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQM7"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="316" mass="33036" checksum="45129FBAD2A2C8A7" modified="2017-04-12" version="1">MSSSAAARQRLQALSKQLVEGIPDEGSFEGIPKIRHIASDSAGPRTKGKVVIVTGANSPNGIGRASAHQFANNGAKAVYICDYNDSHLATHKREIESLYPGVDVHVRQFDAGEEKAVVAVIDDAIAKYGRLDIFFANAGIVGQPKIFTEIDGDGFMNTMRTNALGVFLAAKHAAPAMKVTSETKPYPSGSIICTASVAGLRSNAGSTDYSASKAAVVSIAQTVSYQLAGTGIRINAICPGLIETGMTQAVFDHARKRGTERKIGQLNPLQRGAVADEVARVALFLGSDESSYVNGQAWAVCGGLSAGHPVVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT34</accession>
    <name>A0A1Q5TT34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_6892</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT34"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000082">
        <property type="entry name" value="Endopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012795847" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="482"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP03389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="649" mass="72787" checksum="0D4D5C7FD34A2725" modified="2017-04-12" version="1">MLSTVALLTLWASAAASTIPVVQQPLANPDTNPSAHVVPDDVLQPPAGLAASGPRGRFLHITDFHPDQFYKAGTLPDERGGTCHRGKGSAGYFGAEGSDCDSPLSLVNETFRWIEENLKDKIDFVIWTGDSVRHDNDERRPRTADEIVELNEFMAQKWVELFGISDQAKNPTSIPRLSVPVIPTFGNNDILPHNIFRGGPNTWTKKFAGIWRHFIPEDQRHTFVEGGWFTIEVIPGQLAVISLNTMYFFESNSAVDGCSAKSEPGYEHMEWLRVQLQLLRSRGMKAILMGHVAPARSNEKKNWDESCWQKYTLWMDRYRDVVVTGLYGHMNIDHFILQDSHNVDIDAVVEDSTEDTIMISSKEDYLVSLRKQWSSLPSPPSGIFDKLRSSSDSLDYVAAKKKKKSKKEKKREKKERRYLKKIGGPFAERYSLSLVSPSLVPNYFPTLRVVEYNITGLETLLVQDDSIYNGIETSVDASTAEGSIPLEAQNPAVEIEKKKKKKDKDKDKDNKPPNFKIPDPPSSTAPPGPAYSNQPFTLLAYTQYFANLTRINDEAASQKNKAPRVDFEVEYSTDDDGACQMKDLTVRSFLELAIRIGEEGAAATGTTFSLDPSITKKKKVNEAWRTFLSRAFTGFVDVDDLNVSVYNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT44</accession>
    <name>A0A1Q5TT44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT44"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="32106" checksum="4FE641801C6F9113" modified="2017-04-12" version="1">MLRSLQEESYPTSTPEDGLRQRRAFIEKWATASQEFRESCPSIRLSSRLPGLGALTASPTTGQALPVPAIRRPAGPSRNYIRLVKFLTLLYVHQDYWGGTHPFETAGAGYAPRCHVPELLDLPARTALYLNQADFHALSMTRRGTVVFADGPDYSWYVIDTPGLAIGQMAIVEFGSNGQVRDSILRRPWNIGLVVLFGEMGRRVADLAESSIGGPPRINEPLDMDRPILELLESTRQSNKFMDVGYGHPDLWLQIIEKSAPGYLELEAQGREVEFELNDLVQCDAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D0</accession>
    <name>A0A1Q5U0D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0D0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0D0"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP05924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="19682" checksum="FEA5FB6C1C79F71C" modified="2017-04-12" version="1">MIFSTAIARPLQLVTRTLQWSSAVIVMGLTSYFIKQGPKGQHLIYQEVIAVLSVAFFLPAFISPFLPTALSKFVLLIDVVFSYLWLTAFIFAAQDYNQHSCYFNAPPGITCSRKKANESFIFLAFIFTFFGMFLEVASLWAYRKETATAAPIAEKTQPGVRPPLDAPVEQNVPAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2A4</accession>
    <name>A0A1Q5U2A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rpb7-binding protein seb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000596">
        <property type="protein sequence ID" value="OKP06602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U2A4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="10893" checksum="4C225490C6EE9AE7" modified="2017-04-12" version="1">MSSAVAELDSYLRSMLAXKPPGITGSKVHSITRLCTANVQDEPALIQKVYTHFKKAPATHKLGVLYVVDSIARHWVDATRKAGRPPRSAAPDGTTLVVSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4D2</accession>
    <name>A0A1Q5U4D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U4D2"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1326" mass="143752" checksum="16754E8D31085D59" modified="2017-04-12" version="1">MPSRRHQQPQLQVPVLPTFPLSSPISEEISSPSCSSAEDRDLERNRPFDFLVKATKHKIELKSGKDGNGNGNGNRSPNLSQRDHHKRHSIRGITKKRKNVAKPVGLNLVTDFSLAAPPKKQVDNGGPAPFVDLNDLKLLSKDRAKERSGQTKGLTSTNDDEIFEITNFTNIPNISRKRASFHQLPEETSRIQSETGNPFLDPKVVENPFSDRFDHGLSPSDRHVMIGLSVPRNESLHHTREIDSAGTPLTPSIIVTPAREDAPWSTSSPEGLRPRATSSIYSQPTPRLWQNGPDIPPVPAIPAEHSRKAAESDFLGAHFAAMTRKHRSMSAETIIEDDIPDRTHVHEPLEDNDQAPLTRLSVNTQALRPESQGWWTYLLSPLLGKKSPLSPSFPRSTAPITSSTKEPRKLEWWEKEVSCFSPETPESAVKSSWQEDKKSLEQSRSLGGNEEPDSSSAKRQTTTSMIFGGRAIQGEAAEYYQACAHELFSKTETPYFECHNHICSITPAAVVAAIYAAQFKADEGETRDRGLIFAEAQAHETSRSLPQHSGGNKGLLIDIDSPTEDGSKGLGDSKEIDSPASTASSDSWSSSITDEDEVDHGKALPGPPQGVTRGVVPDVPSEQPIHPPPAAVPVHEPVPAPTAFMPEPPPPGPIPVAPAVMPEPPSLVQPPPPQIINTISPPVNNIHYMPQPVAMPPESAPVERAAPQYAPMFPPVNEPPPPVPMPREQSRGLSEWPFVPPAAHTPMHEESTRAAPVPVPVGGLPKSELQQENHVPPPIPNHNEPISPAFQRAAAGGPGAIPMSSMNEVQAPAPAYTQNPRDEAALPPRYALHPAPGAAIMNSTGDAGPGEARRQRLEREDAIGRKIGGFWRGRACFPKKGCFGRPGREGRTKRRWYFCICMFFLIIVVLAIVLALTLTRKGDTTQVQSNWLNLTGYPPMPTGISTVAGAEPQVQKSTCIKPSSLWSCALPKGQQSDNQPYAANEPNFRLEIRFRNGTYNHSTVPLSSKTRRDANSWDPSPSPPSLADQTFLGNTTDGNSLPYAGEETPFYMTLLSPLKITSTSNTNSLSRRSATNDTTTFPNLTAVIPAPAENSDGTAAAATLYPLPESQPVRLYNRGQDNEHYGFYTYFDKSIFLASRAPLNGSATDLSPLDTNGGSTESDAVVRCTWSQSRFLVQIWTQPSKMGYNLLKNGSNSSTTATSTSAAATPTLSSTSSSSASDFTRPGSFPYPISITVDRHGGAEKKKLLYCYGIESDQHYNITDRKLQLEDRGFGGTLVNPASGIFDDLDGDSSSGSSSNSTTGYGGVDGGSGGCECLWSNWVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4E9</accession>
    <name>A0A1Q5U4E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4E9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4E9"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP07353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="587" mass="65099" checksum="16746E59392B5C1A" modified="2017-04-12" version="1">MAPISIVDLVAALPAEDVWGPATSGDNMLEGVPYAPFSKGDKLGRMADWTAESKDRAGQGRQQYNRNFRDQQVYGAGSSSLFAIQTAEDESSFSVVDNTRTSTKRTFGRGGGTVFRGRGGQRGGQLQRGGARGGFQRAGGGRGQDRFYDQRGNRGRGGRRFGWKDYDKPQRTREPSVNIRPEWHMIEEVDFNRLSKLNLDTPEGEDLESYGFLHYYDRSYDKVPVKGAERKLQSLERAAYNVTTSQDPVIHELAEKNEATVFATSDILSMLMCATRSVYSWDIIIVHQGGKIYLDKRAGASIDLVTVNENAYDAPLEVSEASGKQEQINTPSALAMEATFINHNFALQTVTESDQAKVSFTHPNPFYNEAEETEPLASKGYKYRRFDIGLERDEEPIQLIVRTEVDAVMKNPTGGADQQLVVKALNEFDSKAPGSGNALDWRSKLASQRGAVLATEMKNNSSKLARWTTQAILAKADGMKLGFVSRANPRSAAGHVVLGVAGYKPKEFATQMNLNLSNGWGIVRTVVDRIRSLDADEPVDAVKKYVLIKDPNRNVLRLYSVPASTFDEDEDAEIDEKEEENDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4J3</accession>
    <name>A0A1Q5U4J3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribokinase</fullName>
            <shortName evidence="9">RK</shortName>
            <ecNumber evidence="9">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_5991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4J3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4J3"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="10">
        <location>
            <begin position="12"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="298"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP07402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="357" mass="36974" checksum="803A0E0E48BD42EB" modified="2017-04-12" version="1">MGIKSTMPSQPHISVIGSLNIDFVTSTPRCPGAGETLTATSLTVTAGGKGGNQATACGRASFTAPATQDVTVSMIGAVGANDVYYSTLLKPALEKSGVSTANIEESEQAQTGSATIIVEDGAGGENRILVVPGANHMGMMADAGALVDVVETQVVRPGVVVLQGEIPRETTLGLLEYFNGGVSGEERVHVVFNPAPVYPEGIELDALKHTSVLIMNETEAVQMSRSIAGLPVSDSTQPTELDDLQPEELAPRFHETAGVQIVLITLGAKGVYYSTRSGRCGAVPGVRVPKVVDTTAAGDTFVGYFSTALARFLAKGEPLEAFDSEIESAVKTANAAAAKCVAARGAMQSIPFAYDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4L6</accession>
    <name>A0A1Q5U4L6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4L6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4L6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="56"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP07423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="519" mass="57087" checksum="E775BC94F7A45EA7" modified="2017-04-12" version="1">MTTSLAVTDDKTSVAEVEIAKHEPAPVRSTVAHYEPVTEEEKALDKRVNLKFDLCVIVFLSLGFILLGIDKTNVGFVATSTFVKDAHLKPNDIPNSLSLFSATYVPLQPISSIIGRRVGAKWWITALMTAFGSICIAHMAVRSSSTFYALRLILGVAESGFTPTAYYYMSTFYPKFSLGFRMGMFSGMYAVAGAFAGLLAYGLLHLETSSLRGWQMLFLVEGIITVVVALVAAVIMPADISKAWFLTEVERAHALRRMERDSQTTSDSGIRDGVDSDGDLYTAKDDQKITMRDIKDVFMDWKKLLIIVFNILSVLPVTAFTTFLPLVVQGMGYSGIQATLMSVPPFVVGTAGLLAIVYSSDHFKERSLHTCFGMALGLIGCLVMATSSNPRLRYGFAHVCLSGVFAGGPLIAVWLAGNTPQKGPRAIILGLNGWSNIAGVIAGQLFKHSYAPSYRYPLIVTMILIAVGIVGFCSVRGLYMLENRRRRKEIATWDQARFAMEESSTTRRGDQRHTWIYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U790</accession>
    <name>A0A1Q5U790_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U790"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF6">
        <property type="entry name" value="SECRETED THAUMATIN-LIKE PROTEIN CALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012908685" description="Antigenic thaumatin-like protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18211" checksum="C8154324F9CD05AF" modified="2017-04-12" version="1">MIFANVFIASVLAATATALPHRVRDSSSSSSGNVQFVNNMGSDIYLWTTSSDPGSMKTLSSGGGTYSEEWQTNSNGGGISIKLSTTQDENSVLQFEYTVDSDTLYWDLSSINLDSSSEFIKSGFSVKPSDSSCKTATCEAGDTNCAESYQHPDDVNTLSCSVDAQYIVTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8T6</accession>
    <name>A0A1Q5U8T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8T6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="139" mass="15580" checksum="BDCACEB32068CA9A" modified="2017-04-12" version="1">MAISDNDVKKFESIGVVSQGSTCNDVSMTTPENQREDPNHMLTVFEYRRKTAICIEETAVEKRDKMLKPNAISSLSTLVESTGSRTLAIDWNNLDVGTDLNVLPALPRSVETLEILSMPEMFTSNIECREGNKQVNWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8U4</accession>
    <name>A0A1Q5U8U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor sulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8U4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U8U4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="1">
        <location>
            <begin position="36"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdenum cofactor sulfurase middle" evidence="2">
        <location>
            <begin position="308"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="632" mass="70312" checksum="C2CCD23B0007F3BC" modified="2017-04-12" version="1">MPMKTNSVENPTGCGCVDNYCRNIEGLREREFPDMQTPLDVSKTAPDFVALSLAKIFGFPDLGALLVRKDTVYALDGRKAFGYGSINMVKASGDKWYAKRTASIRERFEDGTLSHSKIIALGTAFGTHERLYGSMANISAHTSWLAGEAYDRLSVLRHFNGTKLCQIYRSEYGNPRLQGPVIALKLSNSRGIGIPSADVKELAATRDIQLYVDSACNLNGTASSLMCTRTGRQRFYAATPGCCGDDHDVLVGRPTGALRISLGAMTSLNDITVLVSFLHDTYVEEGPDTTHLLPPQPSVKPFAAQLFVEALTVFPILGCGGYSIPMGKRWEIHENGLAWNHTWCLIHDATNEILESHKHPRMLEIRPTVQLHHRVLHLSCFKWTGPNQFNVKIPLPVAQPNQRCRPSTESVRRHKDILWVQKYDISPVKTFFSKVLGEPCTLAIICSQRTTETLPPSPPSGTYRSRLRRVFRPKASWSCFSCAKSDRCCSSVCSVEKTTPKVLGTSLQCESVTRFSEVENEYLNQTSLDCDEKQANIMVGEQPTRSTNEKYPFRQCHWPTIRIGPSKVQFDSARKVGPVDHELLEANKPSVSVGVRQFTGHITYENYTIQSPKGDNGHRRTIAAGDMVVPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8U7</accession>
    <name>A0A1Q5U8U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8U7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U8U7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="33945" checksum="E4F80DD75826B53B" modified="2017-04-12" version="1">MTTPEDQRNKTASMPDLEQLGKERPHTFSGLWPEEFYISGSNILLPTLIKELDIPAASTIWPTTALSLAVTSTLLIFGRLIDMYGGYIIYNAGVIWLMISSILCGVSRTWLSLVVCRALQGLALGALLPSGMMILGSTYRPGPRKNLVFSIYGTCAVLGFFAGYFVSGICDQYFSWRWYFFIGAILSAIMAVPSLLYIPRDYAEKRELGIRMDWVGFCLSISGATLFVFAIADSSYAPRGWRTPYVPVLFAIGITLLGVMTYLEAWVIRNPLIPGDIFRVKFMTPLILALLCLYGSLGIFLLYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9S0</accession>
    <name>A0A1Q5U9S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="11">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAH18</name>
        <name evidence="14" type="ORF">PENSUB_5426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="11">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9S0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9S0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000015">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="12">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="227"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="67"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="406"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="445"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="555"/>
            <end position="556"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="561"/>
            <end position="565"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP09218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="642" mass="72294" checksum="F1E655C1F7993439" modified="2017-04-12" version="1">MSMSTQGPGHERSALILYGTETGNAQEVAEELGALTERLRFATHVSELNQSKPEALLSYTLIIFVVSTTGQGDLPANARTFWKSLLLKKLPPTYLNGVNFATFGLGDSSYPKFNWAARKLYKRLLQLGANDIYPTGEADQQHPEGLEGTFIPWMTDFRKHLMDRHPLPPGQHPIPDDVQLPPKWILQSKNDTELVATPEPQAPESDAAQVDEYPGLTHLDYDLRPLPDTLTATLTENRRFTPQKHWQDVRRISITVPESVPYVPGDMIAITPKTSPTDVQIFIDLMGWDEQADKPIALVPTGDTRAPPPILGLEAYPNLTLRSLLIDYLDIKAIPRRSFFSNIAHYTDDIMHKERLLEFTNPEYLDELWDYTSRPRRSILEVLHEFDSVKIPWQHAASVLPVIRARQFSIASGGQRKQTADGKTQFELLIAIVKYQTVIKRIREGVCTKYLSTLRPGSTLRVQLQPGGLNSSVRQLTASTVLIGPGTGIAPLRSMLWEKAALVQAFREENPGVEPPIGPTVLLYGGRNRTADFFFEEEWEHLSKLIPLQVLTAFSRDQQQKIYVQDTIRQNLTLFFRLLHDMRGSVYICGSSGRMPQAVREALIEAFAEGGAPLTGQPYTRAQAEEFLIGMEKSGRYKQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAD4</accession>
    <name>A0A1Q5UAD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long chain acyl-CoA synthetase 7, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAD4"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="707" mass="78191" checksum="4A996F15BAF2F657" modified="2017-04-12" version="1">MFFSQPAHLAKAEELKQSPPKGQPYSVAIPGTEQPGRTRIYRAWNAQKELLTTLDPQVVTAHDMFESTANRQPKNHCLGWRPFNPVTKAFDAYQWLTYEQVQKRRAAFGAGLVELHHKHQVHKPGQYGIGLWCQNRPEWQITDLACMSQGLYSVSIYDVLAPDATEYIINHADLSCVVTSLPHIPTLLKLKHALPNLKMIVSLDPLDSGEQTGHSKRALLESIAADQDLSIYTIDQVEALGEASKRGYNPPSPSDIVTINYTSGTTGPPKGVVLTHKSAVAATSAGLITIGQARGDTMCSYLPLAHIYARLAEHTAFWGGARIGYFHGNIVELVDDLKLLKPTGFMSVPRLYSRFGTAVRAATVEAPGFKGAMSRHIVAAKTANLNNPDRSKATIKHALYDRIWAKKVAAALGLERARYMVSGSAPLDPTLHNFLRIATGTDIVQGYGLTESYACATAQSTDDLSSGNCGRLAPCTEVCLVSLPDMEYSVDDKPYPRGELLLRGNNMFSEYFKNPEETSKAMTEDGWFRTGDVCQIDEMGRIIIIDRRKNVLKLAQGEYISPERLEGVFMSELGYLAQAYVHGDSIQTFLVGIFGVSPDLFAPFASKVLGRPIAATDLDAIKGALSEEKIRRAVLRDLERVAKKHRLAGYERVRNVSLKLEPFTVENNLLTPTLKLKRPPTVKVYRQLLDKLYEQALEEESAPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB95</accession>
    <name>A0A1Q5UB95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000465">
        <property type="protein sequence ID" value="OKP09739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB95"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="328" mass="37217" checksum="DF195E49FD8696F8" modified="2017-04-12" version="1" fragment="single">QRDPDSTDSYTVAWICALEEEYFCACRMLDEEFPGPEISENNDDNTYAYGRIEKHYVVIGCLPAGRYGTNSAACVARDMVRTFPHLRFALMVGIGGGAPTARNDIRLGDVVVSQPRDGFGGVIQYDLGKFKDGRFHRTGQLNAPPEKLLGVITEMRRLFSDKRKPDRLAEHLQRLDDMEDYQRPAVDRLYATNYPHMDRPTCDGCDFISVVDRPERRNHRLLYVHYGTIASGNSVLKDAIVRDTYAEDPELNILCFEMEAAGLMNNVPCLVVRGICDYCDSHKNDDWHKYAALAAAAYARELLLVLRPQRVDTMLPWAERVTQELQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBJ2</accession>
    <name>A0A1Q5UBJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBJ2"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="20562" checksum="233E2CE1403DC332" modified="2017-04-12" version="1">MACPITISKFVGTVSLGLLTGLSYSTATITIPSLQLLPTATTASRCLNEVKRLNRKHALRLSSLANTCLLFAYCVSPPRRQHPFLVWMCVASTVSSYGLDLWFNRQMGLKNWFFSIIYDTTCVSLGKQSSAKKDDDLVVVEAEEDVNGESVRREMDKERRLQRARAWLSGIALSVGVVGLWGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBS6</accession>
    <name>A0A1Q5UBS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4644</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBS6"/>
    <dbReference type="SMR" id="A0A1Q5UBS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBS6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012976714" evidence="7">
        <location>
            <begin position="18"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="168"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="445"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP09932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="585" mass="64059" checksum="73812AD3162C2364" modified="2017-04-12" version="1">MGSLLFLLLCFTEWASPATVYFAVNLTWANHTVAGVQREIILTNGQYPGPELRLNQGDDVYFDVYNGCPFNATVHFHGIEQIGTPWSDGVPGMSQTPIESYNDFRYHWKADQYGAYFYHAHHRGQLEDGLYGPIYITPSSTVIKPFSLITSDNVEVQAMIDAEENTSPLLLSDWRLLTSEQIWDAEEASGVDAFCANALLINGKGSMTCFSQDEINGLTTPAQKGALGNETLTDIACFPPTVAQGDFPHNPSALLPTMFYGCTPSQGPQQVIDVDPDCPYISLDLTSAAGLLHLTFSIDEHFMWVYAIDGHYIEPVEVNAINIPNGNRYSVLVPVNQTPGDYTIRMVSGSNQQILNTTAILHYEDSDQLKRTSNSWITLTGGNATVDTVFLDDTSVVPYPAIAPSTNVAATYFLTISHFGASYRWTLGNSSFDLELEESQPLLFNQTTIPSDLIIRTDNNTWVDLIIQVDSPAQPAHPIHKHSNKHFAIGQGLGTFTWSSVAEAVQSIPGSFNLVNPPIKDTTATPVADSGPGWLAIRYQVVNPGAFLIHCHIQVHQSGGMSLALLDGVDAWPTVPSNYLNDSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC21</accession>
    <name>A0A1Q5UC21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000401">
        <property type="protein sequence ID" value="OKP10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC21"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13450" checksum="6D7BD7B03368F9F0" modified="2017-04-12" version="1">MNRATYNAADYEEPNDNPNCFTKFLDVASRNPILVAQMFLDKLQAHKQVEDGRNADRPEESYENGLPNLFNLVDPLVHAKHPRQICPTEAWNLRGPLCQSLSRKTSQSKDIERKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC64</accession>
    <name>A0A1Q5UC64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC64"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="194" mass="22087" checksum="B84C11CD0D222F77" modified="2017-04-12" version="1">MTTLEMLPARTLAEVNELEKFLKENTSLQDIVNYTLSHRARLVRPIVSYDASALALSFIPAVEDRDREVDGKSNKSYSYQYLRSDLYDIVTEAGCQLEARYTVPSAHVTIARFVRPVGWSERESGGSDLFHKRAQELVATIEDINQELRSDHWKRFGDPSRGEWVVGQEKGLELMKGRSWYGKGESIIIGKGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCH8</accession>
    <name>A0A1Q5UCH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar calcium ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCH8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="162"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="610"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="767" mass="82791" checksum="DF6915CFB28BB235" modified="2017-04-12" version="1">MGFLAGDDARDMPTKPISARRMGLSTVDGTRQHSWIIGFWFLKYMHRINSWAKAHASSRGLPNQPSTLPQATSQIPEVDPTTESSSTLKDDQVTVPVEDPATTAGSIEEEKSQKPGLVTRMRNGTGRFYNHTKNAICHSWVNVLLVFVPVGIAVEAAGLNPAVIFAMNAVAIIPLAGLLSHATESVASRLGDTMGALINVSFGNAVELIIFIIALVKNEIRIVQASLLGSILANLLLILGMAFLLGGLRFQEQIYNSTVTQMSACMLSLAVTSLLLPTAFHASFSDAAEADRRTLKVSRGTSVVLLLVYILYILFQLRTHSYLYASIPQRIIDEESHPGVLADFMNSSSDSSSSSSDESVDTTSSWTTAKRIKRVMKSRRRRKSSTSSKGTTSRQSVQKKAMIDETPNSVGNSIASNEANSCAVDIGDEIRYDADDDAGQPSEFRSRDFGLAMNRMESARSEKERKRERKKRREHRAEKSRSQPPTQEEQGQNTQPSMKGFTSTPNFAGMPGAGETEQRKRSPFGPIPTLLSNTVFSSQIPAQSPQLGAAASRPGLSRSNSLPARVSRQPPVGNAVQFARGAARVAGPTDPVAPETAVVEVEPEMSRTAAIVMLLLSTGLVAVCAEFLVDAIPDMIENSSVSEAFIGLIILPIVGNAAEHVTAVSVAMKNKMDLSIGVSVGSSIQIAIFVTPLVVIIGWCMDKDMSLYFTLFETICLFVTAFVVNFLVLDGRSNYLEGALLLAAYIIIALAAFFYPGNNETSNLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCK1</accession>
    <name>A0A1Q5UCK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCK1"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="11772" checksum="A24C91BA8548F6C4" modified="2017-04-12" version="1">MERRPSVTQKAASTNKVPTPHTAAPVTRSASYSSPQEDSNGSNSGEKAKEDEGTYSRQLQTASTELLNDERVGLGSKAGRTLQNVLMDTEHRLKEQRRESLHKPGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCP7</accession>
    <name>A0A1Q5UCP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000374">
        <property type="protein sequence ID" value="OKP10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="5700" checksum="E332DCD2E7EF58EB" modified="2017-04-12" version="1">MVVGVVGELDIKIGAGVSKAISRRIAAGFGGKYGRYSDGFDGGGGGCGGRPDRDGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCZ2</accession>
    <name>A0A1Q5UCZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCZ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9484" checksum="75706C6406CEEA60" modified="2017-04-12" version="1">MVNLPEIRSSNGQIATALPGLVAVFVGATSGIGEATLIEFARHARQPLVYFVGRSQEAGDRIQAECRRLKPQRVPPPIPSAAIRTIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEI0</accession>
    <name>A0A1Q5UEI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="13597" checksum="F2BF8F1941318F94" modified="2017-04-12" version="1">MHILVDCRSVALSTRGRPSKLMYSRHQQQSQYPSSATVIICQGWHNHLQSILVKAGDSSHDRASEMNFLDPQYLKPSTAKRSAPSDRPERRQQPSGAWMTAGRMGYIRDWRGVARAVMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF66</accession>
    <name>A0A1Q5UF66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_3473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF66"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="11"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="538" mass="58835" checksum="7BF3393D60AAB9A4" modified="2017-04-12" version="1">MGYVIGNIYVITTVAVIGGALFGFDIASMSAILGTQQYKCFFNQTGHGDDGSCGGPTSSTQGGISAAMPGGSFVGALISGIVTDWLGRRMAIQTGSVIWCIGSAIVCSSFSIAQLVVGRFINGLSVGILSAQVPVYVAELAQPSRRGQVVGAQQWAITWGILIMFYISYGSSFLAGNAAWRLPWGLQMIPAVFLFGMVFLLPESPRWLAKHDRWEEAHEVLALVHSKGDKNAPFVQTELQEIRDMVEFERANADATYLDLFKGNMIYRTHIGMFTQIWSQLTGMNVMMLYITYVFGMAGLSGNANLVASSIQYVINVVMTVFALLFIDRWGRRTPLLVGSTLMMTFMFANGGIMASYGKPAPPGGLNHTPEQSWDLSDAPSAAKGVIACTYLFVASFAPTWGPVSWIYPPELYPLRLRGKAVAVSTASNWVFNFALSYFVPPAFENIKWKTYLVFGVFCFAMTIHVFFAFPETAGKTLEDVETMFNTPGMKPWKTKVQYQHVRQLETGALQSEKMADLQAEAGTRATEKEASAATHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG97</accession>
    <name>A0A1Q5UG97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_2970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG97"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="410"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="611" mass="68205" checksum="7F9428CD38C6D134" modified="2017-04-12" version="1">MANSANRPNTRDSNRSSAQHVLGIPRPPSVGGISSRVTDVASEDGENAPSYTSPPPSLQPRTSVSRRAPPPTRNSIASSSQRPGSSGSRLSRTHIPSLTAQAFFRPMSSQRLQAHRGGRPMTKGTVSSTDDWNDQTSQNRQSLISNSTIPQGSVPHVEMEVPPSRGTEFTDPIIPDRNTSNASPTGNTTVRSLGESVRLLRDRDQQDKPRPGHLNLGANYTGHHTQDLPPKSPLSFLSLQNKGSSHNNHHSNHDVRGHERLSSAGSSPGPMDVKKELPRANLGKNWEYFVGNTLFCFGGRFLNSRDKPINIATGFLVVVPSALFFAFSAPWLWQNVSPAIPILFAYVFYICFSSFVHASVVDPGIMPRNVHPMPPMDSSNDPLSVGPPTNDWVMVKLATSDVAAMDVPVKYCKTCAIWRPPRCYHCRVCDNCVETLDHHCVWLNNCVGRRNYRYFFAFVSSCTILSLFLISASLAHILLYMDREGISFGASISKWRVPWAMVIYGIIAVPYPTSLWAYHLFLVGRGETTREYLNSHKFQKQDRHRPFTQGSVLTNWIAVLGRPRPPTYMQFKRPYEEGDQRYAMQKRKYLPRDVESQTGIEMQNVGPHRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGH5</accession>
    <name>A0A1Q5UGH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGH5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8048" checksum="A2094FCD62087465" modified="2017-04-12" version="1">MPLHRNAEDGRNSGQTGRRLQAADFDAPEGQVIREIQLCATAACIALAINVILAAVAFAHGYSQKHESDFVTVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGJ9</accession>
    <name>A0A1Q5UGJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000275">
        <property type="protein sequence ID" value="OKP11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGJ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="409" mass="44544" checksum="3A16E4DEDC575776" modified="2017-04-12" version="1">MGYTTLWKRLSPRQLNVTIQVFSLISIFFEGYDQGVMGGVNSSPMYVTEVGIGKPDGTVTDTKHQGGIVSVYYLGAIFGCFAGGWLADRVGRINGLLAGALFALVGGALQSAAQNSDFMICARVVTGIGTGGISVAYWISFGLAFLENGYSDVRWRFLLAFQCFPALILACCIKMLPDSPRYLASVGRIEEARELLKHIRSHKASPEEIDREYLEIVTLAGESQRSSPIQFLKILLGRSGKQHPNLGRRAWLCIWLQIMASWTGITAVTAYSPVLLHQAGYSTIKQNGLAGGLNTVGIVGTIISAQIVDRLGRRVCLMGGAAVLFAVNMIAGAVYEGSLHNPSMAAHYAPAAITMLFLFNIGPFYWKMEQAYALHGDVLVEHGVKTNDHLDSTKNQLTLFEKPEEQRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGN2</accession>
    <name>A0A1Q5UGN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGN2"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="22200" checksum="CB075868E88D1A43" modified="2017-04-12" version="1">MDVPEPDQSPFTAMTAHTSKLTRQYQAYLDASTPYTTYRWVGSVVLLLIFFLRIIFAQGWYIVAYTVGIYLLNLFLAFLTPKFDPSLTQDEGLEDGDAGSPSLPTKRDEEFRPFIRRLPEFKFWHSATRAIAIGFVCTWFSVFDIPVFWPVLVMYWIILFVLTMRRQIQHMIKYRYVPFSFGKTRYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGP9</accession>
    <name>A0A1Q5UGP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGP9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012727938" evidence="1">
        <location>
            <begin position="21"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="9602" checksum="419654D6419C7169" modified="2017-04-12" version="1">MTTTLIYFIFLPLILNPPRPLTTKALIDRLPKALGRTPKALSSASCRLAYPFSRATNGGTKATHDVTNCTGRPLKCFAYGLGETAFDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH68</accession>
    <name>A0A1Q5UH68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_2655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH68"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="359"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="550" mass="60634" checksum="564D9023A60D1B8D" modified="2017-04-12" version="1">MEHSSPLAAMQPPSMLFGHCFRADAPTSYPSLSGFGSNSFNFKDLSMKKSGPDYFNVKPIPSPTASLAADLSQNFHIDQSPQLATPRRSLFTSNILGQANARDDVMTTPPLPSSPAMDVMEMSPLPHKPAFVVTTEIEVHSPSPMCSPMDSPIMSAAPSPLQASPMEAPTRAPLERRRPHFLRPSLAKSKAQSFQLGVNRPNNESKAPAFRFSTAGAKTSLSTSTSLEDMFGDSPPQERSVSRNSSLNTLAPPRLRPPFQHARSSGSPAPNSIRKPSHSTMRPRKQCRRSLSMFEHPADVIAQKEAKVPANAPLQSISDLESSPTPQLPHFVPEDQADTLPRIGKHTLLELLDGKFNDCFDNIMIVDCRFEYEYEGGHINGALNYNDKERLAGELFGAPKSRTALILHCEYSAHRAPIMAKYIRHHDRAVNIDSYPNLTYPDLYILDGGYSSFFAEHRSLCYPQNYVEMNADGHEFACERGLGKVKQRSKLNRAQTFAFGQQSSPMEDSPTGRPRLGNDRSSRLLASPLGSPFAVSPVPNRTPGRRMLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHC0</accession>
    <name>A0A1Q5UHC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHC0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51564" checksum="07287EA3701D33E1" modified="2017-04-12" version="1">MEKEHAPPPGGSNVDLDMVKVRSNLDPRDVGLGQVLETHTTPEMERKHLKGKEYNWASAVFYFGYFTWSWPSSYLVVRLPLGKYLSIAVFLWGGILMCHAACTSFSGLMAARFFLGVGEASIAPGFALITGMFYKREEQPARQAAWFVGNSIASVIGGLVAYGIGLIHNNSVTSWQLLFLVLGAITSGYGLILFVFLPDSPVKVMFLNKTEKSVAVQRTLTNKTGVMDTGKFRWSQVMMAIKDPQTWFLVLYTLCVNFCNGGITSFSSIIIAGFGFSNLKALLIQMPLGAAQLVFLLLTSGFATYVKQSRIFMMMLNAFVSVIGMILIWKLDSHNRAGRMTGLCLGAVFAANIPLSLSLISSNVAGFTKKSTVSALMFVAYCIGNIVGPQFFIPSEKPGYPTGIKAAMSGLVLGIFFLICLYVYYVWENRRRDQLYGSPRELTEAEELQEELSNKTDGEIESFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHC7</accession>
    <name>A0A1Q5UHC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHC7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="15824" checksum="9441B63C8A2C5FE3" modified="2017-04-12" version="1">MVGYEQGHWAAEVVRENHFKRSTVLAEYPKPKNKKQMDNDQFQSEVRSKESPLNNYLSTDGTPLALTIDDNSSPLNIGEVLGLKLKHDQFRFSEVPTFITYNIKREYQLEWRMGLEVGGETLRVEGRHPVLIMEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHF2</accession>
    <name>A0A1Q5UHF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHF2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHF2"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000283">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="271"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="381"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="495"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="588" mass="65446" checksum="8C9BA36FDF7F68CE" modified="2017-04-12" version="1">MNGDTYSSRDSGRPRDHFRDERRDRDRGDRGDRAERGGGGQGGGERRRSRSPHFGSRGARREPEANSYSSSRDYRAREREDRYSGRREDREWDRGDRGERGERPERPERPERGERGERGGDRGDRRRRDFDDRPRRDLFDERPRRGGRDDRRDRGEQDRGGDRRGGGGGPGGDRAPRRSASPPRRKEPTPDLTDVPSVLERKRRLTQWDIKPPGYENVTAEQAKLSGMFPLPGAPRQQPMDPSRLQAFMNQPAGGSAETTALKPSNSRQSKRLFVYNIPAGATGDSIMSFFNLQLNGLNVVHSVDPCISAQVADDQSFALLEFKSPNDATVALAFDGITMAEGAEKGLEVRRPKDYIVPNGSAEQEYQEGVLLNEVPDSPNKICVSNIPAYIPEEPVTMLLKSFGELKSFVLVKDASTEESRGIAFCEYADPTATTIAVEGLNGMELGDRHLKVVRASIGTTQAAGLDMGVNAMSMFAKTTSQDMETGRVLQLLNMVTVDELLDNDDYEEILEDVQEECAKYGKVLSLKIPRPTGGNRQAAGVGKIYVKFETQESASSALKALAGRKFSDRTVVVSYFGEENFDVDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHG2</accession>
    <name>A0A1Q5UHG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_2563</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHG2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHG2"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000415">
        <property type="entry name" value="Mitochondrial carrier protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000283">
        <property type="entry name" value="Solute carrier family 25 (Mitochondrial aspartate/glutamate transporter), member 12/13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="337"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="436"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="534"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="690" mass="76939" checksum="27155EE5035E3B22" modified="2017-04-12" version="1">MASVKETVKETLVGSKEAPELSHQARSIFVRHAQKDENGDLFMTEDEFINAVAPKQEDYHKIKREQYGILFRVADRRRTGKLSLADWATFENLLAKPDAEYEIAFRLFDLEGSGTVKWETVKGMYNQNKSADSIPFDWNSEWASLYTGRTKSRHDMTYPQFSQMLRGLQGERIRQAFHIFDKDGDGYIEPEDFQRIILETSQHKLSDHLLENLPTLCNISTSKKISYATVRAFQNIMREMDIIDLIVREATLKSTDGKITRSDFLNEAARVTRFSLFTPMEADILFHFAGLDAPSGRLSQKDFAKVIDASWRIPVAVAGQAMEAAATKTEAFLHSVLESAHHFALGSLAGAFGAFMVYPIDLVKTRMQNQRSNRPGERLYNNSLDCARKVIRNEGFTGLYSGVIPQLIGVAPEKAIKLTVNDLVRGAFTDKDTHKIWYPHEILAGGTAGACQVVFTNPLEIVKIRLQVQGEIAKNVEGAPRRSALWIVKNLGLVGLYKGATACLLRDVPFSAIYFPTYAHLKSDFFGETATNKLGVVQLLTAGAIAGMPAAYLTTPCDVIKTRLQVEARKGETKYTGLRHCATTVWKEEGLKAFFKGGPARILRSSPQFGFTLAAYEVLQKMLPLPGSEQDVSPTGQVEPGVGLRGAKAPLPYLRSRNALKLILDVDQNIGRVQVPRPESWPKIMQAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHP1</accession>
    <name>A0A1Q5UHP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kyphoscoliosis peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHP1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="461"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="749" mass="80439" checksum="89665240D04C7DD8" modified="2017-04-12" version="1">MTEEPRLGSIQQRIAALKQSQAAQSSNGPEPPPFLRPPTERSKSANIPPSYAVTGSVIDNASIGNEPASIQTQRSAPRPPPALSPKPELKPKKAPPPVPTRRSDRPPPPPPPVRSESPARPEPPSRSQLPARQESRPNLPPRRPTQLSHRPSQESVLSDASHSTTATSVGRGASTTSLNSNGNGRIKAPAWGETVLPVLPPRRPREDPIDLTPAPRSESKFSKSGLTGKLSALRGKIPGSSSSSTSTSTSSRPSVPSRPSARDPSPAGPRLPPRRPSGVETQSNDTYGEADEEEVRPSLPARRLPPPSAVNNLPDPRQLGLGGLNKSPGIPLRPRSTPTGNGASRVPPPVPTGSRPDLAKLNATKPRFNSSTSGATAPVGITSTECLVCRDFSGPDARAAQYPRESLPTHDLGWLANELTAPFPSLTDKARVIFTWLHHNIKYDVVAFFNNAVKPSTPGSTLASGLAVCEGYAALFAILATKAGLEAIVIGGHGKGYGHTPLAPGQPVPPYDAGHAWNAVKIDGGQWKLIDPCWGAGAVNGPGQPYIQRFEPHMFTISNEEFGLKHFPGNKDHFFRSDGRLITWEEYITTDPDSPTGLKPIQIYSDADKYTIGRKTLYPAGGNISIYNTPGPVRFQFGLRCEHWTLARHSRQKPGLFLLMIHGVDGREEDRRVFQHVPGSGPGGGGEMWYVDVADARELGAPGQKVQLAVLTTLGERHDCRGVTAQEYQSQVGRVGMSWAYIAEWTLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHY2</accession>
    <name>A0A1Q5UHY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHY2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHY2"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="231" mass="26266" checksum="AEC0C34D5056CE36" modified="2017-04-12" version="1">METLKAVFFGPDPQAQMRKCNALIRQNTRQLDRDLYQLKALDSKTRQYIINASRRAQRNPSQAKQAMSETKTFARELVRIRKQTTRLSTSRAQLQSVGMQVNEAFQVRKIQGSLQKSTAIMKDVNMLVRMPELTSTMHQLSTELVRAGIIEEYVDDALPDDSLFEDELDEAEEEVDKILQEILQGKLSQAPANPVAQPVDEAPVAAEPEEEFEDQEATLSQMRDRLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI25</accession>
    <name>A0A1Q5UI25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI25"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI25"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="306" mass="35047" checksum="E2DA3E5154E487A8" modified="2017-04-12" version="1">MSLQRVARANVLRHLRLGDVLSHQTRVIGVQNQLRRLSLATNSRFSTPLAGSISAVTSQQSRSFATETASPKKSTKKSTTKKPKAEKKKPKRGLTEKQKEAKEKKESRELVKQLKETALQPPKKLAQTARTIATQAKLKEVREQNPSRPQAEIFKEAVELVNSQRLAEADRYVNQAEENRAANEASYAAWLKEYTPLQIKQANSARKHLRRLGHSKFYGIQDERLVKAPLNTYMFFLKERHDSSDFKHLPVKDAALRIAEEWKGLTDLEKQPYIEKAERDQERYREEYREAYGEDAPLPKPKASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIB8</accession>
    <name>A0A1Q5UIB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIB8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="412" mass="46221" checksum="C28F6AFE212CEFB9" modified="2017-04-12" version="1">MPEDIHASTSQFSIAVSIFYVTYVLFESPWAVLMKKLTPRNILTGLCIVWSLTTIFTGFIKSVGSLYATRLILGACEAGLFPCLNLYLTMVYRREEQAKRVSYLLSCAAISGAVGGLLAYAILHMDGVAGKAGWRWVYIIEGIFSALCAILIWFGLPNDPAEAYFLNDEEKWMMRVRNEQRRKYMGSEKFSWEEMRIALRDPKLYFSGLIQFCQDILLYGFSTFLPTILKGMGYNSLMSNVLTVPVYIWAASVFIAVAFCADRYSKFASFIFATNIFGIIGYILLLAVSNRAVQYFATFLIGITTYTGVGLNVAWINVNVAPQYRRALEIGLQQTMGNCAGIVAGQIYRKSPYVLGNSFSLGVLVVAQIAVAGLGFYLRRENRVKEQIENGEKEDTRRVRTGDGAVDFKYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIS1</accession>
    <name>A0A1Q5UIS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_2113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="14">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIS1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000008">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="490" mass="55652" checksum="E3A47BA955D6A968" modified="2017-04-12" version="1">MVLRKASKKRAPVQSVQGVQSVQGTRDSESGKPLGAIVFIFGLSTLIYAFTFLCNDVSGCPVPSLLNPSTLSLDKLKEEVGWPQGGLKAFFDIRVTLWVLSYYLLSLALYVFLPGEVVEGTELACKGRLRYKFNALSTYVYGADCVLWVFLWDNYLQIITANLMICMILATFVYAKSFSVPEPDQLNPELRELAPGGQTGNALYDFFIGRELNPRVKLPILFVDEASRTIDINVWCEMRPGLLGWIILNLSNMARQYRTYGYISNSIALSTAFQTFYVLDALYLERAVLTTMDVIMDGFGYMLSFGHLVWVPFIYNLQTRYLAVFPLELCLKDILLTLIITGVGYSIFRGANNQKNRFRTDPNDPRVKHIKYIQTSSGSKLMISGWWGLARHINYFGDWLMSWSYSLPTGLAGYTMVESINSAGHVQKQAIQTPEVRGWGIVFTYFFMLYFGVLLIHREGRDEEKCKRKYGADWKRYTSIVPSRIVPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ75</accession>
    <name>A0A1Q5UJ75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ75"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ75"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="786" mass="86889" checksum="43983FCB51C14250" modified="2017-04-12" version="1">MRKPSLTGIVYETLFPRQRSTDPGSFASHITRNLVPEVRIETNAFYGPLDCIEAQYPGLDYAYAPHRLRLGRFPWHRRLFRAFDELKLTEEEISGICCWEGTKSARQRYEMEEGITVRDTTGDTTRVATPTPPPAVRIHPDFYTLTEESEEDEEDYFDMMVETGSDDTVRASSSRTSSALADYRPSFGEDEYSDEEVESCGLALNNRLLAATAARAQGANVPVDADYEQWLKDANERGGYDWMVAAIRANQPLNNPEAAISSPSSPIVDDSEPRDQASEVDEAIRSASLAAAMRAAESRYPLRYPDPPEITDFTHMATPRRSPNWRQFPAEDDTDCPKVVHQVPDGAIVPSSTAPAQPLFLTFSDVSFFVIPRQELCGNLLQVCTNGYRILGYPICMKSDRYSRNEFIFNFCIVLAEEEDFSQYKSVVQKLADLMHALEEQNGFLSRDFSKTGEGKVYSLCEMLMEDLNNYCECMIPIAIYAPTAQFSLTIGSDEAMQLECARYVNTRFAPHRPIGPHTPLPPQIVPVAAATSGGSTGGAGPLSSPLTDPAPSLSRDESRFDAEEIWPLLGDPEDVPHSGRKVPDIPENNSIPAGQGPRVVDGVGIVELYAALKQGQSVKQWYSQHNRELANIDIRRFITFGVIKGFLYRVHKYACATGQPAPTPRSSSVAPITASAGPSSRATTGNNTPYAASSVGEDAPIHARRDGSRERAASFHSGSRGGIGSGSAPSGVFEDEEDEIDDRTLSKFLDGTHSFDQICTELEISERELTVRLKRYPGEVLILHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJB0</accession>
    <name>A0A1Q5UJB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette sub-family D member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1885</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJB0"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="171"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="521"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="782"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="740"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="818" mass="91722" checksum="F73084E77B0B52A0" modified="2017-04-12" version="1">MAAQSTLRRPEDPLLALYLRYSELLRSRMKHPRTQLIATIALLLSIIGSGYGGYKWFHERAKERAQGHRLHRRNSGIRGKDGSRTIYVPYKESTSKVLIHPTKPTTFDAHRRLFLNPPASARSSEDGSAIPPPTTKPGLNLAFLHQFLSLGSIMVPRWGSKETGLLMSHGVFLLLRTYLSLLIARLDGEIVRDLVAGKGKAFLWGIVKWCGIGTLASYTNAMIKFLQSKVSIAFRTRLTRYIHDLYLTENHNFYKLMNLDGGIQGPDQFITQDLTLFCTAAASLYSSLGKPMVDLFVFNYQLYRSLGPLALSGILTGYFSTAVVLRKLSPPFGKLKAVEGKKEGDFRGLHSRLLANAEEISFYGGADTERVFLVRSFKELQRWMEGIYSLKIRYNMLEDMILKYSWSAFGYLVTSLPVFLPAWGGLGGAMELADAAGGRERGRMKEFITNKRLMLSLADAGGRMMYSIKDISELAGYTSRVYTLIATLHRIHANAYYPNRGSELYSLADVQGTTHNGFDGVRLEQVPIVAPSLYPMGGDELIESLSFIVHSGDHLLISGPNGVGKSAIPRIVAGLWPVYRGLVSRPRPIGLDGIMFLPQRPYLSVGTLRDQVIYPHTEIDMREGGESDAALQKILDAVHLGYLPQREGGWDARKEWKDVLSGGEKQRMAMARLFYHEPRYAFIDEGTSAVSSDVEGVLYERAKERGITLITISTRASLKKYHTYNLTLGLGEGDLWEFERIGTEKEKLGVEKELQELRKRLDKVDEWKKRREEIENELGKVWAHDGEVAPPPYQEEEAKPVSETGAEAPVEEIEAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJK0</accession>
    <name>A0A1Q5UJK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJK0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11211" checksum="BB2EDF8BAF238D1B" modified="2017-04-12" version="1">MDDADTGGQQATVYTPPELTALLDLTRKRSSNTPKLFGYKIGTQDRLGLVPGGLIIWLVWEIVPGLRLGDSDGADSFWGLESSEREQVRSVFIKALRELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK00</accession>
    <name>A0A1Q5UK00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK00"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK00"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="464"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="677" mass="75911" checksum="ECF5BAAC6AA1C744" modified="2017-04-12" version="1">MPPPPPPPPQSVYHSSSVPILPSTPASDGTHAGQESEQNYYKSNNVTVFAWNGNNPENIEFEFPRLEDKSGTISLRSVVIQYVGALQSRKVAADKLFQIIGRLRCLQYAIERYNCGLLSQTQEFLQYWRRHTLGLLSGFGFRPGAELETIQIDGLAELISRLELMFQQNIHAAQELITSGMITFDGLGELFKPDIPIKSTSISGSVPCAYRVTDSFYEEYRTLFGSQKHFHVTMEAVVLVGDHFSVASFSEVLSAWSGIRVRSLTEFSYQPLTESERQIFQARGERAVSHGLGGAKYLSYGPNTFYVHTTRSRRDAPGMAQATNSSISLTGGRVMIDVARGSSLGHYPCQGVDEVTLSIIQLAGRYRQWLSKRSRFNTLETEQLVLWDSVPQEFVLFFWPALVGFSFTAKAWGHVLVDGLSPINFQDQAFDHLVLKQERKDLIRAVVRHRTALQTPDVIGGKQGGQIFLLHGPPGVGKTLTAEAIAEVLYRPLYYVTMGELGVTPEDLERRLSDVLELCAEWDALAVLDEADVFLETRSTCDLIRNAMVCVMLRILEYHPGILFLTTNRVRTLDPAFESRITVALRYEELDRDARMQIWKSQVERLPTQLSADIDYHRLAEQPLNGRHIKNAARLALSLATEKKSPLTESLLLTTVDVISIGYQNILADDAWETRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK01</accession>
    <name>A0A1Q5UK01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL2m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1536</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK01"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK01"/>
    <dbReference type="OrthoDB" id="268576at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000034">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000128">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="10">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="9">
        <location>
            <begin position="211"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="403" mass="44763" checksum="252113A1579A7DB2" modified="2017-04-12" version="1">MLQPRLALRGIRLPFRCLPTIPTLPVRRFATAVNELETPASKVSPPSSDFSASFAPPPTRDDSGVQLRTYTPRTPGVRHLRRPVNDHLWKGRPIHRLTFPKRGHAKGGRNNSGRVTVRHHGGGHKRRIRMVDFMRTDAGPHLVERIEYDPGRSAHIALVRSKETTKLSYILAADGMRAGDVVQSYMSGIPDDLWQSMGGTVDPGVLAARTAWRGNCLPLHMIPVGTLIFNVGLRPGKGGQLCRSAGTHATVVAKGSDSRQQEIETDQPEEEKKPLTLREKQKQERLAQHITVRLSSGETRLIHKDCCATIGVASNPNYHYTQLGKAGRSRWLNIRPTVRGLAMNAMDHPHGGGRGKSKGNVDPKSPWGIPTKSGYKTRPKWKINKAVVHPRPRNQGQRRRGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK05</accession>
    <name>A0A1Q5UK05_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NAD-dependent protein deacetylase hst1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK05"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="155"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="486" mass="53557" checksum="CF8497234E210CC1" modified="2017-04-12" version="1">MTLVPAPSGKTPVKSPVVEVEAVEAVDVVEQVEAETVALEEASSEFETDSDDSEDWDTLSHGGDTIQFLRDEQLRDGLVPGACTLEEAVAFRQRLHDIGKAAFVEETIARETVTAKKLCTAFGIMPPAFLEGAPDESYHPLLAVALSREFARRPKLPQYNTIEDAVRLLQESKNIVVLTGAGISTSLGIPDFRSKDTGLYSKLEHLGLSDPQEVFDIHVFREDPSIFFSIAKDILPMEKKFSPTHGFIKLLQDKGKLLTNYTQNIDNIEGNAGVSPDKIVQCHGSFATATCVKCKFKVLGDVIFGDIRDGKIPECTACQEAIARDALQPQGLKRKRSSSGHQKDRKEFEDSSDEDDYEIPTPGVMKPDITFFGEDLPDEFGQRLIHHDRELVDLVIVIGTSLKVAPVAEVPGILPRHVPQIYISRTPVSHTGFDIDLLGDCDVVVSELCRRAGWNLEHHMIPADEKVEVTPVEGHESRHVFKVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK25</accession>
    <name>A0A1Q5UK25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK25"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK25"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000041">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="52193" checksum="48794CF5F3CC09DD" modified="2017-04-12" version="1">MNILRTGASVPRVLRPCRPQSVLRTRFPIPPVASRAFHAGPSLWGIKSQILKDVGEGITEVQIIQWYVEEGAHIEEWKPLCQYQSDKAVDDITSRYAGVIKKLHFEADDTVPTGRALCDIEVEDGKYPDDQPPHDTTLEPEPPAAAPESGILATAQEAETSPIDPQVPEEIIETPKSKHASLATPAVRGLLKTHMVDILDVNGTGKEGRVLKEDVLKYVETRDSPVSAVSPKVTLSITPDTRQTESEVSLTPIQSAMFKTMTKSLSTPHLLFADELKVNDINSIRKKLVSDARDPKKITFLPFIVKAVSLALNQYPILNARVDTSDPNKPKIIMREKHNIGIAMDTPKGLIVPNIKDVANRSIFDIAAEISRLSALGKEGKLGPADLSGGTITVSNIGNIGGTYVAPVIVPSEVAILGVGRTRTVPVFDDQGEVTRGDMVNFSWSADHRVIDGATMARMGNRVRELIESPELMLLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKS3</accession>
    <name>A0A1Q5UKS3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_1170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKS3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKS3"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="374"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="723" mass="77586" checksum="8668D144C3A0C5B5" modified="2017-04-12" version="1">MDAIKETFARCKEQRRAALVAYITAGYPTVEEAVDILLGLENGGADIIELGIPFTDPIADGPTIQKANTKALENGVTVTTVLELVRTARRRGLKAPLMLMGYYNPVLRYGEERLLKDCKEAGVNGFIMVDLPPEEAVRFRDLCASTGLSYVPLIAPATSDSRMKLLCKIADSFIYVVSRMGVTGATGTISANIPELLKRVHEYSGNVPAALGFGVSTREHFLSIQDTAEGVVIGSQIITVVGNAPAGQAAKAAEEYLSGITGLKRERDAQGAWTREINVIEAVQKALPDAESAPTKVITEAETPAGPGLADQLEALNVTKDPSAQPSRFGEFGGQYVPESLMDCLAELEKGFDVARNDPKFWEEFRSYYPYMGRPSSLHLAQRLTDHVGGANIWLKREDLNHTGSHKINNALGQILIARRLGKTQIIAETGAGQHGVATATVCAKFGMKCTVYMGAEDVRRQALNVFRMKLLGASVVAVDAGSRTLRDAVNEALRAWVVELDTTHYIIGSAIGPHPFPTIVRTFQSVIGEETKQQMKEAIGKLPDAVVACVGGGSNAVGMFYPFANDHSVKLIGVEAGGDGVDTPRHSATLSGGSKGVLHGVRTYVLQNEHGQISETHSISAGLDYPGVGPELSAWKDADRATFIAADDSQALAGFRALSQHEGIIPALESSHAVWGCMQLAKTMKKGENIVLNLSGRGDKDVQSVADELPRLGPKIGWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX2</accession>
    <name>A0A1Q5UKX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKX2"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF4">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011811510" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP13136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="35346" checksum="B0F66B550587CF39" modified="2017-04-12" version="1">MAIKSSVLASLALFGSALAQSVDGSQYNNPTAGPPASFFAAATTVPVAALQSAAAKASTAAKDATYPINGDGGAPKSTIHSDWTNFSEGAAFVWVADMDVDCDGLDYKCKGNPDGQPNTNFGALAAYEVPFFVIPDKFGTTYANVLPGNNIGAVICNGKMFYGIYGDTDGDSPQVIGEASWLMARTCFPNDDLNGNSGHGGVDVTYILFTGKDAVLPSSALNKNYVTNFSTLRSMGDKLITALAKNLNLVSGGGPSTTTLTTKVSSTTTSTGSGSTSTSCSWAGHCIGSSCSSNDDCSDALVCKSGKCAASGSTSGGSCSWAGHCAGASCSSNDDCSDELVCSSGQCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM14</accession>
    <name>A0A1Q5UM14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39007" checksum="D7BBA60AE26389C9" modified="2017-04-12" version="1">MKCSRVEALEKKVDLLMSQLVTLTRQNGQISPDTSYPPTKELDSSVDPELDSTDMATLLDAAQDPSHGRAPPTSSILEGQPSIVDRGLLSEAEAERLVTTFKLELVPIFPFVLIANSATAASLKDREPFLFLCVVAATMGSAHPLRKTVADEIMKHVTLRVVARSERNLELLRGLLVHCIIQRSKELIHIIRSLPASEIAQMTIMSSARVCAAVGYIPSAVFTLLNIIANTTDSTLEAQLQAIVQEADYPNVVTELANALETRCGEMSTAEKEMDIVGSLCLKMRLLARCYPYQIRATVGGGPSQDSMQDTSTMAVPANEHAMMPQIWPSTYGDPGDIFPIDDIQWDSLLNEFTGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM93</accession>
    <name>A0A1Q5UM93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_807</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM93"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM93"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="16">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="154" mass="17174" checksum="77CD62F04DE48B17" modified="2017-04-12" version="1">MDHAKLAKMQQSVRIGIGKGTPRRKVKKVHRTADADDKKLQTTLKKLNVQPIQGIEEVNMFKEDGNVIHFGAPRVHASVPSNTFALYGHGEEKELTELVPGILNQLGPDSLASLRKLAESYQNMQKAQGEKKDDDEEDDIPDLVEGENFESKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UML9</accession>
    <name>A0A1Q5UML9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UML9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UML9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="953" mass="103344" checksum="CF0AF966BC08D265" modified="2017-04-12" version="1">MQLITLPVRIWMCIQYRQRPQSPDVSQRRAPQVNQPGAATIRDASSLSTYDGSSSGISGELKKLTDDTTQQAARETAGVKFDESVIEKQPGPDSQSPEQSVVLPSEGKTEEKKGMSKKPLDKSESTAENLPVGKARKKKKKNKRQRLNLKKRKALAKAAEGVHADAQPQQQQPNDEQSAFTASAAAGQYLVVGNLTLLEVELRSPTSATASFGTARSPSLSRISISSRNFHTPPLSFAGESVEEDLPAPFGSDLETTSLPGDSREPKMISPETITGARRESDERRSAAAANPANATTHPPEISPRSERESPIPTSKVGPVVGSLSEPQAVRGKWKKRQKWIPMKLNSGQDPVKTEEDGLDDTSAATAHVKARQQVVAPQDVSGITYQPLHPRAEPSSRPATRYQSPMKGQEQQRAGDITTMAEALQSLDLDNSSTASAGVPSSISGSVPPRSTSRQSLVTSPESAEFRPSSFAVVSASHPRRNKFSPAAKSTLTPGLPPRPVVTVDRPTRRGARRGAPPTHAHPAKMPGSNATVPAGRKPGGGFVSGANPAMTPGPMMSAAPAGPHGGFAPSPIVAPSYGAHQQKPSQRHQASTPAGSLHEGNPATSTDLYGSSDPQTSGGGAYPTPPTMMAPGPASAPGNDVCAMEGCEKQCCLWDSQSVICPFCGPYSRVIYCGKEHLREDALAHWLYCRQAPMEHYCVENSVPPDVLVGAPAIPCKNGWDSPERHRQAVWFSTARREGEYFIFADWEDSSSAGTTPVFGDGRCSTRVNVIVRFDDPIEKDRFRRILAVCLLESVEVQPLVAYMFRLLRDKLQSTNQWSSRLDLQVRYQLNLELGVSLDPNLLGNRHACETEWNGQSPRNCRDPICVAERPHFFVSVTGVQWFEGLVFNEECNHWILRASRTTHPDVKKVHARTRGEGFDVVEEEQRLFRRGEGWDGAGTGPMEMEGPEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMU9</accession>
    <name>A0A1Q5UMU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMU9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMU9"/>
    <dbReference type="OrthoDB" id="5325862at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="29402" checksum="3B979A5CC01FE30A" modified="2017-04-12" version="1">MSTTTLATKSELNYLEKEVRTSLSASSSSTLCSTLDDQSPFHPDKTLLIQARGVGCFRLPLPNRQLEIDILHPDGHLAYTSTRDRVCSGNSVLSNAKLGDLIRTEYFFGPNRDPVVHLLQSSAGNTNTNTEEIHLRGQWTSRSVSFTTPSGSELRWSYAKEKRPDGRKVNLIVLGVVENSTDEKKASQIPERRLAQLLRCEETRTPQTSRSSAGNGGTLQMDEEGLREYGVDEALVVATCLTMLKKEVDRRRMIQMMVIAGAAGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN64</accession>
    <name>A0A1Q5UN64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN64"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="61" mass="7237" checksum="F3E83FB8A8DEB532" modified="2017-04-12" version="1">MNASKLYRKGNDEAEQTKYHRYPQRESCRLRPHRNADDPTNRGDFMVRSYNNPPGTNYGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN71</accession>
    <name>A0A1Q5UN71_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN71"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN71"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="6979" checksum="7DA061C96215A1C0" modified="2017-04-12" version="1">MTVRQQQRKWWQLQWFAESDTKEERRLILKLDLLIVPYAFLAYWTKYIDQANISMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPK7</accession>
    <name>A0A1Q5UPK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">INO80 complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_14182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPK7"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="43542" checksum="35C86DB355FCCD97" modified="2017-04-12" version="1">MASREASPLSSIGTADDSDHDSVKHESRAQSPSASTMPPSKRRRTGVASWDRHTPMSSLQDEIPPPPSPTASISSDTSGEIPNSPLLFGAALGGNTQEDDYSGQSGDQVTVCMWDGCTAGDLGNMDGLVQHIHNEHIGTRQKRYSCEWMDCSRKGQTHASAYALRAHMRSHTREKPFYCTLPECDRNFTRSDALTKHMRSVHELDNLRPTEVKAAAVGSVTGTPASKLQRIRLKLSQPAREPGSETEHPNEPVLTTITAHDDTEDTSMPEFGPELGFDERELAIPPRDLHRLLRRQIFWAEKETAQLKAEWDELRPKREQAWLEKEAIFDDVIEAELRLFSAIVGDISGPSAVPGNLATSLEKLQHQQLHFKQQQEQLQAKSAEVAEGDVDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPN1</accession>
    <name>A0A1Q5UPN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_14049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPN1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPN1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="574" mass="61416" checksum="059381362E173835" modified="2017-04-12" version="1">MFSGSSSPPKDKTDAASSPVPGIDTSALSIHPENASPRDKRFSPPGAGFFNRRQSEQEGPVGDKKRRSSTVTKAASFFSNAKNSLSLNGTRESFSVVGTSPSGSESPLQRLGRMDPALSVPQGSFNNSAGESQPTARSSFRVGVTEDRNRKCRRTMEDTHAYLYNFLGTPAPTAPDINGNDPPGASSESQASDASTNVVETDNGYFSIFDGHAGTFAAEWCGKKLHLILEDIIRKNPNTPVPELLDQTFTSVDQQLEKLPLKNSGCTAVIAVLRWEDRVPSAQSATGSAAIASAAAAGRNDANADSKDTPAQEGPSVSIPKLQRKAQRQRVLYTANVGDARIVLCRNGKALRLSYDHKGSDENEGKRIANAGGLILNNRVNGVLAVTRALGDAYLKDLVTGHPYTTETVIQPDADEFIILACDGLWDVCSDQEAVDLIRNVQDAQHASKILVDHALARFSTDNLSCMVIRLDSTRLKNVVNNKAEPIGVDGDPATNVAQGISEADKIVEGARKRMAKAGINDSETAEQVGEETLQRMANKSETSESELSAKEQQHGDLPSVDILTSTHASKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPV1</accession>
    <name>A0A1Q5UPV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPV1"/>
    <dbReference type="OrthoDB" id="5334391at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="516" mass="60009" checksum="98B3129302DA0E6F" modified="2017-04-12" version="1">MTVPLSSGQATCHDLAFLPRDLFLIILELLEPKDLVWCRRVSRAWNEAFSNPDIVLPLFKRHFPWTQEFKNLQPGSSKYDGSSVTAESIRHAFDQAVARYNHLERGTPRSVQRHSLCSEMGWSWERQFYPVQPWEGHASHYMGEVDRQFTEAMWTYEDGLLVFPSADRWMLMLVDLSSDKQFLVPFVLDGRIIRRVRLQKRVLVVEWAEPKAFHWLNESDGVHRHFATSFNVVPSDKYDHDGRWHIIPRNEWKIMFLGHPLSERDRFFSAHSDTHYVIYIWQPNRSLYTADEDAPIESLFVWDISKKSDYRPSLDPSGAQTGPEVDQSPSIVARFGFQDLEHFRIRQRGFPRIQQLEVSDDGQTVYITENFRFFDATELPTPLGVPDTVVTGIPTTGIGPHNRFTPDFILTAYRSNDNAHELPLLLFNMSHLHESWYNIIAQVTDRGSGVALRIHFSSDEVNDYLDESIYLTVETEKTRVTREVSDFAGRAKLCGCDKYIIGETDNRELVIYRFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ38</accession>
    <name>A0A1Q5UQ38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rhamnogalacturonan hydrolase</fullName>
            <ecNumber evidence="12">3.2.1.171</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_13926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Endohydrolysis of alpha-D-GalA-(1-&gt;2)-alpha-L-Rha glycosidic bond in the rhamnogalacturonan I backbone with initial inversion of anomeric configuration releasing oligosaccharides with beta-D-GalA at the reducing end.</text>
            <dbReference type="EC" id="3.2.1.171"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.171" evidence="12"/>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ38"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000025">
        <property type="entry name" value="Probable rhamnogalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010378904" description="rhamnogalacturonan hydrolase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP14574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="453" mass="47486" checksum="9D9FDD8A7321F6EA" modified="2017-04-12" version="1">MIFNAALLAIGLAPLLATAQLSGSVGPTTSYTTKASNKICNVLNYGGVADKKTDIGPAITSAWSACKSGGVVYIPSGDYALGSWVTLTGGKSTAIRLDGTIYRTGTGGGNMIFIEHTSDFELFSSTSKGAVQGFGYEFHKKGSLSGPRILRLYEVTDFSVHDLALVDSPSFHFSMDTCENGEVYNMAIRGGNSGGLDGIDVWSTNIWVHDVEVTNKDECVTVKSPAKNILVENIYCNWSGGCAMGSLSSDVDISDVVYRNIYTWSSNQMYMIKSNGGSGSVSNLVLENFIGHGNAYSLDIDQQWSSMSTVDGDGVQLNNITIKNWKGTEANGAQRGPIKVNCAADAPCTDVTIEDFAMWTESGSYQKEICNNAYGSGACLKSGSGGSYSTTVTVKTAPTGYSAATMAADLKTAFGTVSSIPIPTIPTSFYPGATPISALAGAAKTTSTCSCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ42</accession>
    <name>A0A1Q5UQ42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ42"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056398">
        <property type="entry name" value="Tudor_Coilin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23086">
        <property type="entry name" value="Tudor_Coilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Coilin tudor" evidence="2">
        <location>
            <begin position="779"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1178"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1218"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1291"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1304" mass="142371" checksum="7CEA9B74DBDF53D7" modified="2017-04-12" version="1">MRLHLVISRHGLPVTRILWTTTSSSSALGEYGTHHPASASMVASSRTPNIAFANGGYTVAQLLEDVNEVVPLETEPTIFDPEFSGQWGLEDYVVEVGGSECLHFMEVDGLLRDGDEVVIRALQLADLRARRLCGRHQITGDGKHLIDGVPFGMPFYKRTTATRPAITIPPRKKRRTVFSGWDQGPAFGYEDANAGVNAEDAGDGEWLPPNNAAFGKELSILPPDHEVSDMGTVIRHPVNYSGDTDNETDGSEDESDVSEEEAADSAAEADELEDELKALKEEFEEPASQFIDIRAQSQVSAGHALRASSIAKRPSSADTQGKSSLVGASSLSSKRSRGEDSSPRSSKAVRFDKVKHGAPGISDNDFLRGSSASSVTSDLSAESESDSGDEDEEEDEDEDEESSEEESSISSSSDSDDSSSSSEEDTSESEDEEVDLPPQKMIQPMIINPPGEGSTRTKKSNQRFKLRRRLSKLKELGVLPEEADFAALRTWEEQNGGWHVPDETSILSTTATTKAQRKEEEQREFQAKREKLLRALASGGVDIDKTSEKENMPPSQPAVVEEAVSTEKATAEKAEAETSNRRTLDIASSRRLLFGSLGVRTPKTEEDEEATRRKLAAKASTVHSRKVSEPQPAEEMVEESDGDNDWENKLVIKAVECIYDDIELSAPPFPFEQRWDEDADALIRQRKGWGKKRKRKQRIQVYNGEEEGEYEDGNGYDGYENNMQLNYDNEWPTAEDETTNMESYQENAEAYHEAAEAHVVDDLPTMPSEPSSVADLVEGDAKVGAIIAFRQLDLSKATNWQPQMSEYRVAEVHQVLGHGNLNVRLAVRDRRPKAAEIDPEDDQGREYSGFEMPGMDDEDEEDDGYREIAFAELSEPKLLRPAPEGKDDAANGNEKKATTEDNPREGSNESVVEDSMPNPQLTSPPPPIDMDLDETTFVTTITTTSCPQSPNGSPARASEMLSGRTPGGTRIIITRSGDADDEHSDTPAVPSPSFSGFHSARSSPGARLGPRFHETGESNLEGHTLIGDQSMLAADNSHQDYSTMSFLSANQSFSDFLQDSTQQDRQVVDDTLVSGGNDSLLSVVHNPTEHASGKSTPVRSHISASPSIAQDEKSVKPTSSQGASILELLQSGWPEGDNTDQEKDEADNDVNSPEDHDSVIHSNQSRHLSPNPHPSSKPPTSAQQEPEPHSSPNLNTDSLFQYDSPAASTRSKRHAPMSASQPNFSQTSEIIDLTQSPFPTSPERPTSQGGPVSVSKVTGDDGPPSSKKSRMSGKIQEMAEVMVSPATSEKKLKKKKKKRSSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQD5</accession>
    <name>A0A1Q5UQD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:glycoprotein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_11441</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UQD5"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010341178" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="43"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="275"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="411"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="666"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1182"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1461"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1474"/>
            <end position="1488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP14683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1488" mass="166894" checksum="AB1B689B7FB2788B" modified="2017-04-12" version="1">MRNSTRTRASWHWYAALGALLPACLAIASPAVNVALQASFDSSPYLVELLETAAEENATSYFPLLNRIADGAFEEAISEKELYDRFLQVVHEDGHLRTPESLSSFKLSLSVRSSAPRIQAHYQYYNTSVQQSLMGAQDAACPVWVHLEGKQYCSSLMERAQQDVEGESDPKELPFDRVFGDTSLPPAVLYADVSAPTFKDFHDRLSDMAKQGEISYRVRYRPPQHWTSRPLFVSGYGVELALKRTDYIVIDDRDADVSSKDNAATGSEELKDDSPDDLRPLSSSEVSRLGVNSASYVMDSEDPLNTLIKLSQNFPKYSTTIAAHNATAELKKEIRENRARMIPAGYNVIWINGMQIDSRQIDAFSMLDLLRRERTLIQKFRDLSLSAQEAVKLLSHPALAESQAEDESQRYDYRDTLEGGQVIIWMNDLEKDSRYEAWPRNLETYITNHYPGQLPQVRRDLHNVVMPVDLSNPEALLHINQIQSFINRQIPIRFGIVPTASSPDAISQLKVAHYLQETYGLESLFHYLEESTSKNKAGKPDKASFLVATKEREPRTESEVLSFDQVLTSEHYETVATRSADYQRRLGLQGGAPNFLVNGIPVSSATNWMQELSMLISRDLKLIQQGIVEGVLEEDAVLPEFFLAGAFERRNSFIMPEDPKSVRIVDLSTIFGHDSTVLDHIPRVEPESGVLGGIHIIVVGDFESETGLKLLTQALQFRKENGEMELVLVHNGATESEGGMTRLDAVQNALTKGGDIDSILDAVTSTEALETSASDSQEASHIHRRLAESLGFDAGVEGLVVNGRAVGPIPKDYLLSVEELDLLVTYERSKRIEPVAKASLSLRLNKKLTKPLDLAKLTSMVALSTISDVPEGIFESMPDFRLDVADKWKTEHSVITVSNSEDPAINVAAVIDPASETAQRWLPILKVLSELAGVQLKIFLNPKDELKELPVKRFYRYVLESEPSFTSDGSLSRPGASFTGVPVEALLTLGMDVPSSWLVAPKESVYDPDNIKLSALKAGANVDAIYALEHILIEGHSRDVTTNSPPRGVQLVLGTEDNPHFADTIIMANLGYFQFKAQPGVWQISLKPGRSEKLFNIDSVGGLGYRPQPGDENTEVILLSFQGHTLFPRLSRKPGHENEDVLEKGPEPGSARDYISKGFNFASGVLSGVGVGSKPDEQHADINIFSVASGHLYERMLNIMMVSVMRHTKHTVKFWFIEQFLSPSFRAFLPHLAEEYGFAYEMVTYKWPHWLRPQKEKQREIWGYKMLFLDVLFPLSLDKVIFVDADQIVRTDMYDLVTHDLEGAPYGFTPMGDSRTEMEGFRFWKQGYWSNFLRGKPYHISALYVVDLKQFRALAAGDRLRGQYQMLSADPNSLSNLDQDLPNHMQHHIPIHSLPQEWLWCETWCSDEDLATARTIDLCNNPQTKEPKLARARRQVPEWTVYDDEIAALAKRVAAEQVGFVQTGEDAEQKEVSVDENVEEEDDRKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQQ0</accession>
    <name>A0A1Q5UQQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQQ0"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="38898" checksum="022BEF798620E65D" modified="2017-04-12" version="1">MHRTYSMRQSRAPTASQIENPPPPMSSTKSNRWLGKGGIGHAFRKNAAGAFGPDLARKLSQLVKMEKNVMRSMELVARERMEVAQQLSIWGEAADEDVSDVTDKLGVLIYEIGELEDLFVDRYDQYRVTIKSIRNIEASVQPSRDRKQKITDEIAKLKYKDPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKVKAAFQYQFDALREHCEKVAIVAGYGKHLLDLIDDTPVTPGETRHAYDGYEASKAIIQDCEDALSNWVSSKAVVKSNMSQRSRTLSQRHRNNVNKSGEGVDLSHQDQPMTGDRDSWLPADQHPSYDDGEDVLSTVDGETRGREEERVPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URC2</accession>
    <name>A0A1Q5URC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scytalone dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URC2"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="3">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="19975" checksum="DBFCBE0D7ED0C145" modified="2017-04-12" version="1">MAFEIYIPASLTFQDYIGISQCARTLADGYDRKDKSRVRASLAPTIIVDYSKVVPEWGRKTFAADVFVEEWLGPTHLGVKALATQHLLGAPYFKSVTKEEIVIEWQQLASHGRRIEGEDYAHPMCKIDEISDGRSWMQQIFVKVDGQWRISEIRPEVLYHTGDFLKVGRPDGEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URG1</accession>
    <name>A0A1Q5URG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URG1"/>
    <dbReference type="OrthoDB" id="4324149at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="205"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="534" mass="60953" checksum="3464743037FDC336" modified="2017-04-12" version="1">MAPVNPENAARKERLEQAVAEARASKKPNYSALARKYNVKRESLTYHLREAPPTESLRNRMSQEQRAVMLKYVQQLDDANILVSGGLIEVTGNYLLQRDAGGRECKLLSKMWSYRYLERLTIEFKNQKKAHVNLKRLKAEHLDAFADYFRLLKSKIEEHNIGPSNIYNMSLGFQFHQRGLRRGVATDIEGSDTSAAARLKSGALTIIECVAANGFAVPPLFVVKGETHLEWWDDSPDVPEGARESTSPTGWVTPNLAMHWIRHFDAHTKSRVSRGQKRLLLVDGHESHFPPEFFDICATRKIVVLSFVPFSQELLQPLDGQPFLEYEEILHSDINNGEAPLTDKDEFLAQVMSARRVAFNEQTIRDMFANCGIWPLDPEKILQPLQKQLDEAPAPREVPNEPTPEPRAPSPPPRAIRIVRARAEEAVALQKKDAKQVMNQLRQIYNLNLKTCGMVLQLQDDLKKRMEFEEQRSQNRRTPTEVPPRRNIKTSRLVFSRVAKRKLAAQARRRKSLAKYGISGARKRPEVSEAMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URR0</accession>
    <name>A0A1Q5URR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clock-controlled protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URR0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URR0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010221354" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="144" mass="14027" checksum="F4630EA41BFA8992" modified="2017-04-12" version="1">MRFSFAAVVAALAAGVVATDAVTETLTAYTTYCPEATSIVHGGSTYSISTPGHLTMTGSFTVTRPLITQTVTQCNKCSSSTPLPTTPVSSVSSTPLVPSTAGATGTAVSTPAASQPAFNAGAINAATGAGAGLAAVFGAVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URV6</accession>
    <name>A0A1Q5URV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URV6"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="552" mass="60955" checksum="DA3D8A6314479832" modified="2017-04-12" version="1">MAELKATSASAPEKFTSFAHDEHRSDDESPELSASDINYDSNGVRGILNSPYVCGAALLASFGGFSFGYDQGVISLILVMPQFVDQFPQVGENAPNYGFNKGFLTGMLELGAFLGCLLFPYLADRISRKWGITVATAFFTIGAIIQTSAQNYDSLVAGRFIGGIGVGTLAMGAPLYISEIAPPNLRGSLMVLEAISIVIGAIVAYWITYGTRAMSGDWAFRLPFLLQMIPGLVVGFGIHCFPFSPRWLALRDKNQESLQALSKLRRLPTTDKTVLLEWRGILTEDRFQKQILRDQHPNTGPLMMEVKQWLDLFRPRYLKRTCVAIAIPFFQQFSGINAFVYYAPTFFAELGQDYNMSLILSGMVNICQLIGAIPILLYMDKIGRRKIAIYGALAMAIPHLIMAGVVGKFNSSWESHQAVAWFGVALVYIYVLAYALSFGPLAWVLPAEVFPSSRRAKGVGIATATNWLANFIIGTVVPQMLVSIGWGTFLFFGVWCLIASVFSYFLVPETSNKSLEQVAAVFGDNLQADEEDLRRQVQREVWAVSSMQEQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNG0</accession>
    <name>A0A1Q5SNG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-reducing end alpha-L-arabinofuranosidase BoGH43A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNG0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNG0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="329"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO89557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="505" mass="57544" checksum="DDD11C88F60ACBBA" modified="2017-04-12" version="1">MSFTNPIIPGFNPDPSIVRVDKDFFLVTSSFEYFPGAPIYHSRDLIQWKLIGHALTRPSQLQIHTPEPGGGVWATTIRYHKGVFYITAASFQRYRPQQDDRVWPQGFYVKTTNIWDDSTWSNPVYFDQVGFDQDLFWDDDGTVYLSSTYRKLKPTPGVKLKDFAIHICTVDLATGHSTSEPKLIRESSSGVAEGSHIFKRGRYYYLFSAEGGTESGHCEWVSRSEVGPLGPWELAPNNPLWRNGVEDEVQNTGHIDLVEDADGNWWAVLLAVRPMRKGDQWEESVFGRESFLVRVEWENDWPIVNGGKRITLQSNGPGLYQHDIPISWKDDFSSPNLQLGWYRKNTPFSVDYSLAERPNHLRLYGGPYTLSVPASPTMFLRKQTHRFCTWETKLSFQPTSEHTEAGTVVWWNYFTHSSLGIRKRGDQRIIRFKPSEGDVVEVTLDLTGDVVLIIECGNEYRFGYRGPSSEETIWIGSVANHVATKAPPVGAPFTGMIYMKFSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP37</accession>
    <name>A0A1Q5SP37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP37"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SP37"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="406" mass="46323" checksum="2AD1E9EB439DB691" modified="2017-04-12" version="1">MAAELTSIKLNPESHLILDQPLLRLPHELARRNFKTVQRVVEREKEYVLPALRDAANASLSNTQTPDQTLAALDAMISRMQGLKRKMQSLQEEEKKIQMQSRKRIQHLEALYKIPSLADVKYDQWSRVRLDRLLVDHLLRSGYSESAKQLAQERDIEDLVDLDVFTQCQQVVESLHRGETKEALQWCGENKAALKKSQHNLEFELRLQQYIEMVRTQDPSKKIDAINHARKYLVSNQEPDSKEIQRAAGMLVFAQDTRAEPYKTFFSHERWKFLSDLFIQTHHELLSLPSQPLLHIALSAGLSALKTPLCHSAYTSSSSNSQSTTTSVCPICSTELNELARRMPYAHHSKSYVEGDPIVLPNGRVYGKARLLDISKNNGSVESGKVKDPTTGDVFDESEMKKVYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRC4</accession>
    <name>A0A1Q5SRC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRC4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO90548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16116" checksum="C2F541BAE2F6DCE9" modified="2017-04-12" version="1">MIAIAIQRPGDGQIVIAGVINGHVAAKYIYVRLFRGTDRMHKRSVGSIGSWVAITLILWVIAWVIAEAIPVFNDLLSLITALFASWFTYGLSGIFWLFLNWGQYGKSWQKMCLLIVNLIVVVIGGCLLCFSQYIPEAELEAIQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRG3</accession>
    <name>A0A1Q5SRG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRG3"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="21517" checksum="FE200727308DEEAC" modified="2017-04-12" version="1">MPESPELNAAVMAVVDCDDSFKAKIQYLARDEQHRLVKPYYLHFNYESDIPPTNTSPDDRFVHIRNARNLQISSKEMFIQKGFTQLHLDCSLTPEGYCDDQKVEEILYPKYKSAARHLFPNAARIEVLEHAVSKRPDRLKIEHFRTLTCGNQVRKRHPLWLSESLERHELNTNQPSDYVHIGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS57</accession>
    <name>A0A1Q5SS57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease fcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_13130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS57"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS57"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO90829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="56938" checksum="9AFB8F8959650358" modified="2017-04-12" version="1">MAPEHEIATVAVRDERDDDIKTVRSTEQPIDYENKKDSIFPPENANRPNPTGSRLGSLLRAFEQQLVEYNLEARGIERVAPDERMKRLSWVSYLQTFLLWVSINLAANNITLGMLGPAVYGLSFTDSALCAVFGAIAGSLVSAWVATWGPLSGIRTMAFGRYSMGWWPSKIIVLLNLVQMIGYCLIDCVVGGQILSAVSPGGLSVAVGIVIIAIISWVVATFGIQVFHYYERFAFLPQLIVVCILFGVSSSKFDLSTVSQGDPRTVAGNSAAITYAPLAADFFVYYPENTSRLTIFSLTLAGLVFSFTMALVCGIGLASGISANPEYEAAYTLGQGALIVEGFGPLHGFGKFCSVIIALGLIANTVAPTYSAGVDFQILGRYAEKVPRVIWNTVGVIIFTVCALAGRTHLSEIFTNFLALMGYWVAIWFAILIEEFVFRWHTGYNWAAWRDPSKLPIGIAALVAFVVGWVGAVLCMAQVWYIGPLAKLVGEYGADMGNYVGFSWAALVYPPLRLLELRFIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS98</accession>
    <name>A0A1Q5SS98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="6"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="52991" checksum="20B0EF2798C99214" modified="2017-04-12" version="1">MPSKGKRLVVCLDGTWVNSDQGYNRPTIHDPNYTLQVPSNVTRLYRALRKKGLDGMSQVVYYHPGVGSTGSVSDEIAGGVFGSGVSENIREAYSFIATNYEAGDEIILLGFSRGAFTARSVAGLITEIGLLTSKGMEYLYPIFKDTENFRNPDYKDKFPTIPFPHKPLDQREYKLRLEDHAFQALALDEVRTSFAPAVWERPRGVHTDLRQVWFCGAHSNVGGGLPDQELANVSMAWMMDQLADLGVAFEENTIDRIFQESVCYYYDQEQDGRQTNDSPKQNRWKKWALESIYEEHKPVRPWGLGEIVQPEVGFYKLAGKTTRTPGMYHRIDPDTALPTRDFLENTHERIHRSVRVRLALEGLNYDDVGLYKCRALLRKGPWLLEKVRVRTRREVRDRDAYGDEEDVIQQKEESRWGWVYDGPVEETPPQVILLEEVLGPHEKKLLSLNKGMLEMLLPIFWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSR7</accession>
    <name>A0A1Q5SSR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSR7"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="14"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="26674" checksum="A571F8690853905B" modified="2017-04-12" version="1">MEFKGSDRGPFVPALIIVDMQEDFCPPNGSLAVQDGRTLAPLINDLLSQPGFVTRIATQDYHPADHISFASNHPPPNNRPFESFIEMKNPAPDRKTESKPQQLWPVHCVAGSPGAEMIPEIDAGRIDLFVQKGKHSQVEMYSAFADAFGNLDPAVTSQSVNVDIASVLEKKGVTDVFVVGLAGDYCVKCTAIDAFKAGFRSWLIEEGTKCVMPDNWGKAKEELRVAGVSVIHADDPIVKKLAVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUQ9</accession>
    <name>A0A1Q5SUQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUQ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUQ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="441" mass="50113" checksum="7DE771E2F9A1F57C" modified="2017-04-12" version="1">MRDSEAGLEPAWQGKDGVGLINNKGFYMDSLSVDAPELIAMFKEWSESLYADASSYGLLENISFRTFEDVAIKVFDVIDGPPNPHRIRSISTDVDAVFRIGFVACAVHRPLLEWVTSACALAGARHSIVLIQGRSVSWTKATQRTKWTDMVKQFSDEGFPPAMILQAKILGMNGEYEQAFELMEKRVLPYLTPTRRRQGLFKDITMGDNFESPWRVYALLLASYDANFDSPESRRKADDATRIAALEYNDRKALVEYASIMMNEKNYDKYEECMCRAATFGDKDAILYIANYYYQIFHGRYPTTAERVALAKAEAQGQQAPPTPAKPLATPEDTQSSNIFKSALGWASSFFNQSMSREDYRKLALDWYALGFKHSIPQASFMLALMAREQGEEMDGSIIMDHARTHLEDHPEFAKKIDELRDNWYDPTYVPRLTSKMLAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWP2</accession>
    <name>A0A1Q5SWP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWP2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="118" mass="13639" checksum="FC6EB396EBDE2C8E" modified="2017-04-12" version="1">MLPITRIESTSYFKTLHDARRTRMDVDSSSHVKRAHSHNGPTSIIRNVPSVSDDPRLRYHPNLKPITPPFRLFHPALEYSRKSYDIGRRDSDRNADYVDIMPCVIPIMVWGTPIVIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SX84</accession>
    <name>A0A1Q5SX84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SX84"/>
    <dbReference type="OrthoDB" id="4335389at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="93" mass="10403" checksum="AF0F8F454D8C96AC" modified="2017-04-12" version="1">MSISAKEQAKAQGQEDTREPDVDVRQNDSKFWSGIQPRYMSVDQEKRSQYDLEDVGKPEAVKGNRLLRSKPEGASRYQQPGGPGEERLPPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZC0</accession>
    <name>A0A1Q5SZC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_12410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZC0"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO93347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="24095" checksum="5BA2607E05614E32" modified="2017-04-12" version="1">MSKITVAGVRQNVDELLNYSLNEKKRNFLETVELQIGLKNYDPQRDKRFSGTIKLPSVPRPGMSICILGDQHDLDRAKHHGIDAMSTDDLKKLNKNKKLIKKLARKYDAFLASEALIKQIPRLLGPGLSKAGKFPTPISHAEDMAAKVTDVKSTIKFQLKKVLCLGVAVGNVGMTQDELVANLMLSINYLVSLLKKGWQNVGSLVVKATMSPPKRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZC5</accession>
    <name>A0A1Q5SZC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="402" mass="43951" checksum="71A1B615129F142C" modified="2017-04-12" version="1">MVTKIDKMGGAQPEEDGQDVTAVASSSAVAGTDDMLSLGQVDQALATKMHLVNDAIDEIGFTPYHTKLFFLNGFGISADQVVAQYPPKFTRGAQLGFYLALLVGALFWGSTADIIGRKWAFNFSLFTSAIFAITAGAAPNYPAWATLVAISAFGSGGNLVLDTTVFLEYLPSNKQWLLTLLAGWWGVGQTVAGLVAWPFMSNYSCPTDGTVPCTNANNMGWRYLFYTCGAIVFVLSIARVLVIRFHETPKFLLCQGMDEEVIQTLQNLARKHHRPCQLTLEQLQACGQIRSAHAENRASFSELVVHVRGLFSTRIMTLSTSLVWFSWALIGLGYALYYVYLPEYLASRNASAGETSPNLTWRNYAITNLCAIPGPIIAAFMSEVPILGRRWTMAIGAFITSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZL6</accession>
    <name>A0A1Q5SZL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZL6"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="149"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="33258" checksum="55C679A003BE9B50" modified="2017-04-12" version="1">MPETLGPLDYGCTHWRISSQRAADLYSSGIRLWTKEDLEDIEQQLRQSYAMERFSIRRIDGTIIQISNPMFQVQNPIWKPHVKYQEYWQLVKAQPNGPIETYLCSYIVDWSNQTARNFRELIAQPMQIFDEKQLSWQNSKTCKLLVALVQDVLGTNTVKKVLCFGLGDFCRTAPEWLKNQHDVWDENLEVKNVMGCMIQHSMALTIAQLCRGNEPLPLLAQDPEYTKVAEDILTKKEFKIVGTHGAGGFAEIDKDSIIISPFAAAPVKQIIADLALPVLIISTGFAVFNNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZS7</accession>
    <name>A0A1Q5SZS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein MNN4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012660043" evidence="5">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="269" mass="31437" checksum="9543E02AF98BA37F" modified="2017-04-12" version="1">MHWRTWTTLASALWSTAVTALPSSETPDGSSSSFNTPYIDPTLKDPLWLKYGLNASAEYKYFHEPGRDDILGHYDIRFFTTPVSDAERAETLTHMIRAYLNFFDENDLETWIAHGTLLGWWWNGKILPWDWDMDTQVPDTTLAYLADHYNQTIVEYVIPGGKEKRDYLLDINPWSRQRERGQGHNIIDARFIDVTTGLYIDITGLSRLELDDHPDIWQCKNFHKYRLKDIYPLRRTTFEGAPAKVPFQYDALLMEEYTEDALTTTNFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0A4</accession>
    <name>A0A1Q5T0A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0A4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="179" mass="20095" checksum="4E6C9FE7236F7053" modified="2017-04-12" version="1">MLIASAPPQLPLGPYHTQHSALHDLEFTGVLQPWQGFLSSVQTAHQNYTFRSQTLALTLKTRDPYAQGNVEIGDEHGLLGRFHKHFGDVLNSVFTSHSTGIRFAEFKCVQSTFSGTPDVILKDDNHHVKVAGELKVPWIADHWPEDKYNDIDQLRIILAQPIKYMQGLGALPVYYLGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0J0</accession>
    <name>A0A1Q5T0J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase (NADPH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0J0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0J0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="20421" checksum="93119BBE4C8276DA" modified="2017-04-12" version="1">MRVLVIGGNGQTGRLVIDEALQRGHKITALIRNPSALPAKEGLTIVKGTPLEPSNIESAFNAVQGDIPTAVIVTLASPQVKGTRVMTNAHENLIAAMERHGVSKIATLSSFGVGSSFPNITVIMRFAISRTSFKHLFEDHNQVDMTLKKSGVKFVLFRAARLTQAKKAPVQFFGDDGKGLGVFAGLGGDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0K6</accession>
    <name>A0A1Q5T0K6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0K6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202777" description="GPI anchored serine-rich protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="16748" checksum="8742F0103B69E229" modified="2017-04-12" version="1">MRFAAVTVALFAGLAAALPNGAESTVYQTEEVTITSCAPTVTNCPGRATETGASSAPVVTPSVPAGGVSPVGSSSVSSAPVPVATTSVAPAPAGPSVTVVPVVHTTCQAVTSWSTIAVPTASSPVGGSSGPSHVPSSVAAHSSATAKPSSTPAFNGAGALSGSLGFAGAAAVAAFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0M2</accession>
    <name>A0A1Q5T0M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0M2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0M2"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="57143" checksum="5F3F2BD607C061BF" modified="2017-04-12" version="1">MAGVATAYSTDALTSSGGVDSEKWEFAVPLSTDGTQHSSRTRTSHDSSSALARSKNRNSNGSRSSSISRTVQSHDAPYLNSNRGRRDPSLNRHGSDIGSARDSSGPESTARKEHVESQDGIGFQPEQISENWIHRDKLAKIESEELQQAAILFNRRMRAESKSSAGRGRSHDSHPGAANGPASQTSPTVEHSEPWPELREESRKGFGGKEVDDERKHWDLRRPEEIAADEAAAGMYSNPGLRKSSSRIPISTTSPVPLITGRDSRGARSRAATDERDDDEYGRGRRASEPTTIEPEDFTPSTGSRPGSRGFSNTTQNTPAKKTPPKASGSAGPPGSTNRKTSAPPTNRKTSTARTRAVSGNTSQRPVTRGGEARPPTAINRPEGDPPWLATMYKPDPRLPPDQQMLPTLARKMQQEQWEKEGRAPTTYDRNFAPLAVHPDDAPPVPLKNEEPAAEEKVDEKVEEPLRPIKSPEPPRPNTSTGYSTMPKVQDTPPMGLTPNPNWNPPVVTAQDPPKTEKGCGCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0R2</accession>
    <name>A0A1Q5T0R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0R2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="257" mass="27575" checksum="CF32F1C2BAE355AD" modified="2017-04-12" version="1">MSEFDSRFLRRLVGTKVTTFLEFDPLQQPSAVSSSASAASLSAAPLRASPPGISPLAASPPSAASPSAVSLATDSAAAATLNTATSTTAPSISLSGSSPPEIGCSWIITKKLSERAVHLTQEDVDMGGGSPMTVGKFLCCLEEDPTRMAFMRIYYQIPITGTEDADLATLAQQIQPPEVCGELEAFRLLMSQGCSSVPRFYGYCEKQQGEHDLVPGGFVKYVVWEKVPGEPLTEEFFWSLDPGTREDIRVHFRAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T154</accession>
    <name>A0A1Q5T154_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T154"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T154"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="10937" checksum="78A1FBAC86AFF5BD" modified="2017-04-12" version="1">MSTAELAVSYAALILADDGIEITADKIQTILTAAKVQEVEPIWASIFAKALEGKDVKDLLTNVGSAGPAAAGGPAAAGGAAAPAEAAAEEKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T196</accession>
    <name>A0A1Q5T196_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T196"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T196"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="538" mass="59153" checksum="532F6ADC6E86254A" modified="2017-04-12" version="1">MSVSSVDTETDHDALGKTLTARTSRVSDHMSLAERVTTIPTNMTADPNFEVDWDGEDDPENPKNWSFRYKAMGLLFLSWNTLIVVLYSTSYTSGVELIGEEFGASKTIVTLGLTFYLIGLAIGSMFMAPLSEVYGRKPVCVGCLAVFTILIIPCALAKSVTALIVVRFFGAFFGSVMISTAPGMVADLVDDDHRALAFSIWSIGPLNGPVLGPVIGGFVTQYLGWRWMCWIALILSAVALVLAIILKETYAPTLLQKKAARLRKETEDSRWWSRYDQKASLHEILALNLSRPFVMAVTEPICIFWNIYIAIVYGILYLCFTAYPIVFQNIRGWDLGFSGLAFLGIGVGVLVTIACEPLVRRLINSHAKDPETGRVHPEAMVSFVCICSVLIPIGELWFAWTCSPASIHWIVPLLAGIPFGAGNTGVFIYASNYLTYSYGMYAASALAGNSVIRSVLGGVLPLVGSYMYAGLGPNWSGTLLGLLEVAIVPIPFIFYKYGHRIRMKSTLILRMQEDKKKLEGKRARKAPGEDVEKQNDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2G4</accession>
    <name>A0A1Q5T2G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lovastatin diketide synthase LovF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2G4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2G4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="186"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="27940" checksum="16EB3CC1E1519943" modified="2017-04-12" version="1">MTLDDFQAVIASKVDGAWNLHEVLADYPLDFFVALSSVAGVIGNRGQAAYAAANVFLDGFMEYRRSLGLPGTSIDLTAVRDVGYLAEVDIKRQQEVLKNIGTDGMDEAEVLALLAAAITGDIADSCSGQFIVGLELSTLDHFWAQDAKFSVLYETAKAAHGSGTAGGSGPSAPLNVLLANAGSKEEALHICYEALAVKLAQVLVISLEDMDPSITVASLGLDSLVAIEIRNWIAREANANVQVLELLSSGSLMALAEIILNKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2W7</accession>
    <name>A0A1Q5T2W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 S-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2W7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2W7"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23804">
        <property type="entry name" value="UBCc_UBE2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000077">
        <property type="entry name" value="Ubiquitin conjugating enzyme E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="166"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO94591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="446" mass="49044" checksum="36DD635A9B8F558B" modified="2017-04-12" version="1">MVSNLRRLATDHAALNRDLPPYYLLLPHDGRFAMGDDLSQLKVLITGPPGTPYAEGLWRLDLKMPEDYPKSPPKATFRTKIWHPNVEENTGAVCVDTLKRDWQSKLTLRDVLVTISCLLIHPNPDSALNASAGTLLREDYEAFAHQAKLMTSIHAPIKPAMQAAVKEAKYRGEDPSSIPVDQDEVQSPRPRKQPRLRSNIPKKTVRRLNPPENHLPHAVVEPSLPTLPENGDQDDAMNDSENESLAASGKENDPSLSPTPVLPAPPSPRKNTLGKRPLSVISTSYPDDPDADMMIIDSDSEEEEEEEESAQVSPSARNIAANFIHSRHSPSPQRNPPKLSPSKGNNTPFRLRDDLQIYEDVPDRTRYNGKENHDSGLLGLKERPDMQAATLGNSTNPLSSGPSPTLPAPSVTSKAKPPHRVTKKVGGSARKPAGTKSKPRIGVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2W8</accession>
    <name>A0A1Q5T2W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2W8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2W8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="175" mass="19034" checksum="5DECA8C9DCC572EC" modified="2017-04-12" version="1">MADLEAALRLGLFYMKQPRSTTSRPCKSITLVGSTSSYFGGTGVTAYVASKHGVLGLLRASQSTARDLGVRVNGIAPFLTPTHITAGFSQRWKEQGLEENTPERVAEAIALVALDEARQGDCVLDTQVAGKYFRELESSRMSLLPTWIGADFAEFMGRAMQFFISIGGYVLPKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5L3</accession>
    <name>A0A1Q5T5L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5L3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012343778" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="9202" checksum="A29946BB3BFFE5B5" modified="2017-04-12" version="1">MGMAMAMAMIMLVAVAVAMAIAMVMTVFCKLIDHTVQEEHTDEIQAKAHATHDQDELGGFNLLYTVSITDSYIGRRYTHLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6V1</accession>
    <name>A0A1Q5T6V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6V1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="14242" checksum="0FF607CD58983860" modified="2017-04-12" version="1">MRLRGEGLQQVWAMEQDLRFLVPFVLYGAHSTTAQQASNDSRAAESLVPQLVRAGQQEVRVLVALAGRSGPLVAPTHAVLQGPAKVDELWAQPCLVGLRIEMKVVGDVRYGLPGGVSAAGGCRVASQECPKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T7Z3</accession>
    <name>A0A1Q5T7Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T7Z3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T7Z3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="259" mass="28713" checksum="D3AC21AD1F984982" modified="2017-04-12" version="1">MSRSVHSASPTYPYPEFVPMIGPLAMAPQPYMPMMPEPMQCVPPSPMMHCSMYDAPGWNMLPMYPISPVQPLHDNPGDPFPRFHPRKPWANHPPTSSSPVPDLAQRVVYFQNLNSATTTADLKALLQNVGTVEQCNVTGPSKIHDLPQPHASAIMHSVDEARRAMDMLNGMTFMGSRIRVRMDQFPDNSRKGSWDGKVAQDEPDLMEQTASEKSSECSGCEQDVSFQEPKRMDPHKPLVVDGSGVQKRSLELLSTSAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T853</accession>
    <name>A0A1Q5T853_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T853"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T853"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17189" checksum="6D2A84C0C2625EE8" modified="2017-04-12" version="1">MSADLKPLRLVMACDEAGVPYKDAIKAVLEKNPLVESITDVGVNSTSDKTAYPHPAVEGAKLIKEGKADRGLFICGTGLGVAIAANKVPGIRAVTAHDPFSVERSILSNDAQVLCMGQRVIGVELAKKLAVDWLNYRFDPKSASAAKVQAITDYETQFSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8F0</accession>
    <name>A0A1Q5T8F0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8F0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8F0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="CoA-binding" evidence="2">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="220" mass="23977" checksum="D2FA85904BACC425" modified="2017-04-12" version="1">MEMGDEPKNGEDDAVGESRGLARTPTYLTTLTEKFHWYSNSTLIYTILTIIHLPFLLHSLQYPRQIMDAVKRFFSSPRFAVAGASNDPAKFGFKILAWYHQHSLPVTPLNPRAPQINLPSRAYDTVPSPSKLPSPTQTSLSVVTPPPVTLQVLQEAHSVGIPAVWLQPGTFDDAVLEYAHGHFEAVIAGDGGAGGEGWCVLVDGDEGLDAAGVQWTSQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8N6</accession>
    <name>A0A1Q5T8N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immediate-early protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8N6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8N6"/>
    <dbReference type="OrthoDB" id="5423707at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37609" checksum="9E8D3D7B17415E40" modified="2017-04-12" version="1">MFSNFVIAAKGLFARSESEDTLADPAGASAATTSDMVTATRRGTVTSQPTEEPTTNGSAKQGKRKAQPVTTEKTNDKQSKRRKRNSLEAENTISDAASDSDMDEDSAPKKHFRFGSEEPEPTVPETQLESKSEQDEDEDSDSDDDAPETIDNSAQLMKIKEQARKQEKAKQQEEQLKREKRRKLDETRKLQAKSKPKEITAPSEDIHSESTTTVQGDNTEDARRRALPALLPDDILNAEPVTRPPTPPAENNFGFAIPKKSNKLRFLEKTEKPPKDVQVGDVTIRVLDAPSTKQSSKVALAPKASKHGRGMKEGWLKQQKSTAHVNGLRRTSGGSSGFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8U5</accession>
    <name>A0A1Q5T8U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8U5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8U5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="553" mass="61226" checksum="4ADE9D9EEA91AF95" modified="2017-04-12" version="1">MPASTSIHPNANDFLPFVSNNRPMACDNCRRRKVKCNRTEPCEKCLEASLQCSYHTVPRRKGPKGRTARVLSALPSLQSYDERPTSSSSSSSPSTTSVTPPMACDVPSLMACRPQRISSTVLLAHVNVFLKHLYPIMPVFDSNQVVEDCGRVETLSPPRYAFLLALCAATHLQLNLDARQDDSGLAHAIDHGEVLVAEALRTLREFDPIEHLHVDTVLSSFFLFAAYGNMDQQNHAWHYLSQSISYAYALNLHREQTYTSLPHAEAELRRRVFWLLFITERAYALQRKKPVMLRGNIRKPSIFTSAAPALLYGFVNLISVFEKVTPEFYSWNACDSDDSPIDTFALSEIYQSIASPLPPLTEIPEIQQVDLVVTQQWLQIRLWQTALDRASKSGEVLPLQAPAAAGRAVMGFLASVSHESTDAHGIGIEQKLYDLGTSLVRLSERSVQHAATAQVSYLAADLLSAILTSLVRIRGAQSYLFSSLLQTSESILGLDAVPPVMNLDLPLNLDCNSRLEEWATALVNPSTADKREEAADYIDHQASDRSCGISQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAX4</accession>
    <name>A0A1Q5TAX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uroporphyrinogen-III C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_10186</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAX4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAX4"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 17 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="20">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="19">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="18">
        <location>
            <begin position="286"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO97392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="61202" checksum="C0C9FFE13FE53613" modified="2017-04-12" version="1">MKDASNGFGPAPLMTAWNAESQIHLIVGANPVAAARCAKSLEAGAKPIIIAPETADVHFTLSEHISSGSAQWVRREFQDNDLTTLGREEVDRVVDTVFVTLGGSEPLSAHISKLCRRLRIPVNVTDAPELCSFTLLSTYSDGPLHIGITTSGRGCKLASRLRREIAAFLPANLGLAIDRLGSVRRRLWEEDNDAGLGESNMDGEDDDASGQRHTFNTLVTENDASAAKTRRMRWLSQICEYWPLRKLVSITDEDIDAILKAYSSNKEAEPETNGVNGVNGVSKKGKIILAGSGPGHPDMLTRATYNAIQTADIILADKLVPAPVLELIPRRTEVHIARKFPGNADQAQEEFLQMGLAALRKGQSVLRLKQGDPYLYGRGAEEFEFFRDEGYTPVVLPGITSAMSASLFADIPATHRGVSDQVLVCTGTGRKGAAPVPPAYVPTQTVVFLMALHRLSALIESLTTYSAEDSTRTRTLWPKETPCAIVERASCPDQRVVRSTLEHICLAFEEAGSRPPGLLVVGASCHVLHRPAQGQKWVIEEGFHGLDGLHRELDAPISLIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB77</accession>
    <name>A0A1Q5TB77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB77"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="11570" checksum="8049230742D26B78" modified="2017-04-12" version="1">MSIPIHTITTFRATFNPFTHSSRPCRLLLSLLRTPATSSPASPTHIDIKVTQLPRTSTQQPVMTVGFKGGKEVTLEVGKRGMKIGDVVEEISRVGRALEREASLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC15</accession>
    <name>A0A1Q5TC15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC15"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC15"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="44804" checksum="3D2C5B133A716160" modified="2017-04-12" version="1">MAFPHVHRTRSMDLTKKGRLSNPCLVHRIESSKSVAQLSLEDILQGTTNTAVSAQSRAILEPSVKPRDAKPRLLLMGLRRSGKSSIASVVFHKMPPNETLFLESTTRIQKDSIHSFMDFQVWDFPGQLEYLEPSFDLEDIFGSLGALVWVIDAQDDYLDSVARLNRTILTVQQYYPGINVEVFIHKVDGLSEEYRHDSYQDIVQRITDELNDAGYENAPVHFYLTSIYDYSVFEAFSKVIQKLIPNLSTLENLITTLGNNCGFEKTYLFDVLSKIYIASDTRPVDMAAYEMCSDYIDVIVDISELYSWDHPLRKHKGDQMQEAESHVVLHDETMLHLMEMNKYLCLVSVIRNPEAREKKGLIDMNCRTFQEALNDVFSRSWEREEDHAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCI7</accession>
    <name>A0A1Q5TCI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCI7"/>
    <dbReference type="OrthoDB" id="3433125at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053221">
        <property type="entry name" value="Burnettramic_acid_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887">
        <property type="entry name" value="CHROMOSOME 21, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38887:SF1">
        <property type="entry name" value="RAS MODIFICATION PROTEIN ERF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="533" mass="58805" checksum="A22AB53DAA21A9F9" modified="2017-04-12" version="1">MGKLVKLLGSGIGLTSEAIHAARSRSRSRCDQPSSSAGPTNSAPPEYVEVADDTAEGLIRSGQAERVVNTGDEKPLSKATEAGYDPDGDSSESEDLEALGQDEAAWELDDMAERMRLPTYDESEAAAAAEPEDVKVKKEEEMVRDLVRRAGSPPHPPQRIPCPVIIPQRRPRNKDRGFVRAYAPVLGDCGISQEVFLQFLEDWDKASKASPWIDVVFLAAGIVGFVPDVAAQVVGTVVQVVAGTARELQSRSRRNTFLDRVNEDLLMPRGLYAMIMAFKDEIPGQQSGPLYRLSSSIGKTLFVSEKLDINQTVAKYTNPEPEMSKLKKGLKDIRLTSGQTRGQIELPEAAELVFPDLDRVAEEALEGDGKGKEPGTRDKFKNAGAWVQDYLDRRGQAFYEVEHQGSSLAVPSSDRKSMTSRYNDPNHPANSGSLISLLTGGAVNPAARRQAKREARQERRQVKREYKDSRRVAHGRAPRGPRRVKRKAQRKTIIKKLMQKDVLYLLVVNLPSQEEVQESVTQLEQVMAQTGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCZ2</accession>
    <name>A0A1Q5TCZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000680">
        <property type="protein sequence ID" value="OKO98093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013293403" evidence="2">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="20462" checksum="50336204D36B682E" modified="2017-04-12" version="1">MRVVKLLAILGVALCKAAAEGCGLSSYCIKHDTHDHVRNGQSQSGIVHPASKRAGGVSTTADLKSQGSSPSRIPSMILPRSAAVPTISSFEWTASTVYTTRVITPDHKSQPVQKPFSATFDFDESVYSIREPQSKHLFSVVRLDGLYDQILYCDKLRSYCYRLSSGVYSGYNIYLFELSYFYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDD0</accession>
    <name>A0A1Q5TDD0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_9317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endosome</location>
            <location evidence="5">Multivesicular body membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 5">Prevacuolar compartment membrane</location>
            <topology evidence="1 5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDD0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDD0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="7">
        <location>
            <begin position="207"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="8">
        <location>
            <begin position="369"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="9">
        <location>
            <begin position="512"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="632" mass="68936" checksum="1875C3FBA07C9E25" modified="2017-04-12" version="1">MSTPQPDSQSANRDEPTDENVTPSPAPSPPLAQSRDRSTSPEGPRPPLPPRPNTLSLLNDETASRNANLQAEATTAISRTEFGTQTPEAGGSAYSTLAVRGLSRGLKARASLSHLASPKGSEAGDSASIRSSIPNSDAGDVEALFKDFVATAPAGHPDAASLLHFPEFPADDVNDDEFMSEFDPVGELNEDAGNEDLLLQRWKSKHKHYMILSAAGKPIWTRHGDGGLISTYVGVVQTIISFYEDSGDHLRSFTAGDTKFVIVTRGPLHLVAISRMMESDNQLRLQLEALYMQILSTLTLPSLTHLFSVRPSTDLKRPLQGSETLLSSLADSFTRGSPSTLLSTLECLKLRKVHRQSINNALLKTKVSNLLYGLVVAGGRLVSVVRPKKHSLHPGDLQLLFNMIFEADGIKAGGGESWVPVCLPGFNSSGYLYMYVSFLNLRGDVDDNEDILKDESVAIVLISPDKESFFEMQGMRDLLVEQMEKNGSLKMIAASIDQGRPATTDIVPGTVLHHFLYKSRANVQFTMSSYSPEFTSISRRRRLMSIYNNIHSSIHAKNSHVKVHHCVSRSASSFAWVTPTFELYCVAEPNANRNALVQSASKIAQWVQQEEERLFIIGGASAAKELDAYAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDW7</accession>
    <name>A0A1Q5TDW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter C family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9497</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="294"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="609"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="685" mass="75318" checksum="5056E67F6941204C" modified="2017-04-12" version="1">MAISKAVYGRLVNRVMSMTRAGLMSVIYQRTTELHKYKLGDLQAVTLMGTDTEPAYLLEREVGLTCVVPIAISVGLCMPWSSTCYKLYANLFPRNKVCMLGIVPVSRHIVPAQKDWVVRVQRRMAMTLKMLENMKAIKMLGLDEALYTTVSNLREAELKTSEGFRKLLICTVTLSNLPADFAPYATFTVYTVVALVTRESSLLSTRAFTSLSLISILTGRLLSFIQSLPQFAQCLGCLDRIDAYLSDSDQGTVPGSQTKGQTWPHSDEVVSLKASDCSVAPKEPHSDDSISPSTKTVNIAWSLDSGPIFRNLNLTTNKGITVIVGPSGSGKTTLVETILNDTIVAKCNPHLPAPAVGYCAETPWILNDTIRTNIIGVNGQYEKDWYTFCLSMAALSHDLQSFPAGDLHLVGNNGIALSGGQKKRVALARAIYSRLPVLILDDVWSGLDSKNIQLAQSNLLGENGYCRQAVPPFADHVIVLQGGSVIAKGSYEDVILRVPEIAERYPSDNLEAMELIRNKSGEMIEGIPPMTESTLKESAPANPAGFGEDLSRRDSTWSTYRYYISRAGRWKTAFFLFCCLVSAFFSNFVMSISNSKLYRYPALKLEDSLLIIGIINNTAQALHSDLLKTTLNAPYSFFHKTDSGVTANRFSQDMDLIDMKLPMFAIGFTGGMRPILAFTIKAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TET3</accession>
    <name>A0A1Q5TET3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutS protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TET3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TET3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS connector" evidence="2">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="3">
        <location>
            <begin position="197"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="317" mass="34753" checksum="B826531C61454AA6" modified="2017-04-12" version="1">MSISSRQSTLNSFVPLTVRNSTRRAGTARPTTTATSVASQDIVCAVSESRGVSSTVGLAFVNLATAEVVLCQICDSQTYVKTVTKIGVFEPSDILFMSTAKDSKLHYIIAENLREPTLTFVDRRCWSDKAGHEYLDRLAFPDEVDSLKVTLGGNYFAACSFAAALKYIEFELQRIFASHSLRIKFEPSQGSMTIDLATIVSLELIQNLHNAKSKDSLYGLLNETTTPMGARLLRANIVQPSTERVKLTARYNAVEDLSTKEDMFVSVRQSLKGFLDADKVLTSAGVSSLLDVARQTYKEANADAAELVTKLEGKIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEV7</accession>
    <name>A0A1Q5TEV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEV7"/>
    <dbReference type="OrthoDB" id="5429132at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="248" mass="27713" checksum="017303FD5F999A3D" modified="2017-04-12" version="1">MVDFFLCFDWDGWVSPTGTKAQSRKRVMWGRLQVGNGQICSPRSDLLFTCSTAFATNTSLYTTSLNRFFLVAIFLTPPFRIMKTKVGRTGPIKATTPFGDEFRTSKKDKRQIKHATLMSKIAKSSKTQKKRRPSKKLVANLESLADALPDAADNSHDAASQVNIIKQKTLRHKPGAMKRREKLEKVERDRFAKNMAQMASMQSAAAPAAPAAASEAVPESNPTANRWSALRNFISQTMEQQPVFKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFX4</accession>
    <name>A0A1Q5TFX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-L-arabinofuranosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFX4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFX4"/>
    <dbReference type="OrthoDB" id="4357793at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="206" mass="22536" checksum="8CBE2B15122BEFAD" modified="2017-04-12" version="1">MTAVALCLNVFIRQAQHIGMATIAQSMNVVAPLRTNEQGVLKQTTYCPLLLFSTYMRGQSVAVHVRSPVYTGRTVPEWLASTMNIPILNVSAALSDDDYLNLAVVNISDSKSQEASLPAIQGPVQVFCVGGDENDIRDTNTWGSQKVGVKESTWNDKGKFVFQKHSFTLLRWKVIASRSKIEECGVPVDSTSATLHNALHGVDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGC7</accession>
    <name>A0A1Q5TGC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGC7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGC7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="30061" checksum="80570F787F1E79DF" modified="2017-04-12" version="1">MASPMRVYSAEPAYPALAHSLLAKPESNTTNTRDFVDEVVQNHDWNLKDDWDTGIQAKNSGIFRCGTVIGFSRLRFRSKDTDEYIGQLLPVQNFPNAAQAIGKVSESLQELQENRQNVPAEPTQPVLLIVVGLDTLAEEVIRASNPVRGTALLAATLRNLTRMARAYTSWLSVILINTSGLGPAHFESHYPPDSNHVRNHGDEDARPPGDDGIHSIFQTPGSNLLFTLLMKTLDQGIDTHILLSDVKATQVAEVIKDRVGTGLGKWGIWSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH60</accession>
    <name>A0A1Q5TH60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH60"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="5740" checksum="103CB4DAB1330084" modified="2017-04-12" version="1">MADGGSGEVGFNSPNSADKLTDVWWTNGHYVKAKVDEANFYAEPISGAKGWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLF7</accession>
    <name>A0A1Q5TLF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7618</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLF7"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP01037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="262" mass="28604" checksum="502775973F42C597" modified="2017-04-12" version="1">MHSSLNRLQAVFGFFTTVALVVAGFAALSVLLFPTDTTTASVQLKNVQVVKGRPHYYSTKREEYAQIRFDLDADLTPLFNWNTKQLFVYVYATYSSSDNTNTQTRASEAIIWDSIIPASPSPYSWENLVEKATALLPESLTSSSSSKGKATAGKRNAKKTKTNTASKNKKVAEPVTPGALRLRGQKAKYQISDITGRLAERQNVTLSVGWNVQPWVGALWWAPKTGAVPRTEGHIVSSEVFDFPALKGKKVEGQASASASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM39</accession>
    <name>A0A1Q5TM39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM39"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7583" checksum="C68C0FC5DDA9897A" modified="2017-04-12" version="1">MSGLAGAHGEMLELERRVPSAFAGEGVVGFEGARSDLLPGSHHRRERVALVCWCGGVAVRKEITYLSSVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TP65</accession>
    <name>A0A1Q5TP65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000630">
        <property type="protein sequence ID" value="OKP02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TP65"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TP65"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="220" mass="24402" checksum="5E192259834C256B" modified="2017-04-12" version="1">MASLGLMFTYPGNPRAMKVQAVAALNGRTLEIAPDFVMGKTNKSAEFLSDFPLGKVPVFKSTKGLKLFESGAISQFVAESGPASGQLLGNTAEERALIRQWIDFADNELFGPITPLILWRYGMGAYNEDQEKSSLERLNISLDALEKHLGGRQYMATNQLSLADLSVAAGLYWGFAQVIDREMSSKYPLTSEWYLRIVENDLVKPVFGEHKPLEVRKSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU71</accession>
    <name>A0A1Q5TU71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU71"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25846" checksum="B88272C0A6E67624" modified="2017-04-12" version="1">MGLQKARKLELELYLNRHLILLHQTAYDIPGSSVTILGCTLWSKVPHKARETVHSKIQDFKKVQDWTVDDHNASHDADRTWLLDEIKSLQTKNKNKTQNKKRDILVVTHHAPSLKNTSSPRHANNPWNSAFGTDILSQISDLRGVKAWVIGHTHYCTEFVERGIRVVANQRRYVLPWNESKREKGTREQLRTSDGFDKGFVTKDVSIASNEDVNLATVLSESRTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU96</accession>
    <name>A0A1Q5TU96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allophanate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU96"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU96"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF169">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="517" mass="55615" checksum="8B17F64A6CC9FB79" modified="2017-04-12" version="1">MVATSLDIICGQDGLFGYIGHSSNFIAEAQKLCELKQPCAPPTFDGVLPSISELQQQYKNGLLDLEMIVRSVFDRIERYETVDPSVWISKQSLEDVLEAAKELSAKYAGKPLPRLFGIPFAVKDSIDVAGLVTSVACESFAYIADSTAPSIQHLLDAGALYIGKVNLDQLATGLSGCRSPYGIPHCVYSTDHISGGSSSGSGVAVAAGLVSFAIGTDTAGSTRVPAALNGIVGFKPTKGTISARGLVPACKSLDTITIMAPNLQDAREVWYILDEHDPLDPYAKLPSSLVTWNVDFRGPKEGGFTFGIPPLSLLETCSKAYQELFQATVEKLRSCGGRLVDVDYTPFTKAGELLYDASLVHERLASMGHEFFVQNIDTLHPTIKSIFQSALSSDIKAWQVFHDQAAQTRYTMQAHKIFNALEGGIDTLVVPSVPFHPTIKEMLDNPLVLNSKLGTFTHAGNVVDLCGVSVNAGWMENEDGVKLPFGVTFLGGTGYDGKVLDVAAVFMDVVKESCRDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U071</accession>
    <name>A0A1Q5U071_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutathione synthetase</fullName>
            <shortName evidence="9">GSH-S</shortName>
            <ecNumber evidence="9">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_6585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U071"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U071"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="12">
        <location>
            <begin position="194"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="397"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP05865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="483" mass="54262" checksum="A5C0D8630C9514FB" modified="2017-04-12" version="1">MNGFSEEQTLSLVAQIKDWQCFPTPLPRAKFQQALDIQETFNRLYCSVAEDEQWIHDVIQEIIPVEPLAAALWSIYEAARETGYLQNISVGIFRSDYMLHLNDGVEPRDPGAVFETSLKQVEMNTFSASGGSHANKVGNMHRYLARTGVYNGRDNFLNISSLPKNENIESLASCLALAHTTYGKPRSEEARQTAVLMIVQPNNFNIADERPIEYALWNRDDPVPMYRLEFGADILEYARLTEDRVLLFHPPWLASTEPVEISVVYLRAGYEAEEYDHVGWEARLQLEISAAIKCPSLLSHITTFKKVQQALTAPGALERFLSASDAAAIRETFVPVYPLDESEQGLFARKLACDPVKSANYILKPSLEGGGNNVHGAEIPDYLSSIPRARWCSYILMERIQPPIQTNLLMGPETLNSGETVSELGILGSCLWQSQSKQTSDHRCQMIHNSVGGWTFKTKFADVDEMSVVKGYGHFDTPRLMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1H0</accession>
    <name>A0A1Q5U1H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1H0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1H0"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP06329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="28188" checksum="56F79EA302F28CB4" modified="2017-04-12" version="1">MAATVSSLFSLSGRTAVVTGGTRGIGQAMALALAEAGADIILIQRDESNTATKDEIINRLGRKAHIHVAELSDRKAVKEIIPAVVSQGFKPDILLNCAGIQRRHPSEKFPDEDWDEVLEVNLSQVFILCREFGAYLLARDASEFPSGRRGSIINVASLLTFQGGITVPAYAASKGGVGQLTKALSNEWVAKGINVNAIAPGYIATDMNTALINDESRNTSIMARIPAGRWGQPEDFKGVVVFLASGASSYVSGEIITVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1K0</accession>
    <name>A0A1Q5U1K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_6346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1K0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1K0"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP06356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="364" mass="41462" checksum="44D72F668DE87D88" modified="2017-04-12" version="1">MSVLQQFPGVHWVWHGSISFVYEVHPLIVVKVPKPGELEREQFQHEIKVYEIFSQNPPCPSIVQCFLYTDNGIFLEYMRDVSLYCRIHNNNNYDPETRLVTKVDRLEPPALRKEWMNDITQAVAFLESLNLAHGDLRPENILLDRDRLKLSDFDCSAEPGTDFEACMAPYGRILNGDEVDQGARGTSGFLGPRTEQFALGSIFYLINYGFEVYGNQSLTEDPGEHGPKVEDLLQNMKFPTLDGDPLIDEMINKCWHNKYAAIAELATYTKTLLLERNTGSDINTETTPVPECATDEATQFETVDSENPDGSASDMCQYQWPEDFSSKKEFCQSLEKRGLLEVLSSGEPNQLGFELKFYSYSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1K8</accession>
    <name>A0A1Q5U1K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1K8"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="74064" checksum="C21B57FA6114BE4E" modified="2017-04-12" version="1">MPARSQQNHKPSNARHARTTSWSSGYHHLNTSSGPGEPSSPLPQPSRRRRESNLSLASVEEGLSSPDSPHVHHNHNGSNAPDMLRNTSMDLDLAGRKSQHVRSRSQSHGTPHILALHESELNAANTLPVPVTPRPAPVTWMSLPRKGQLALLGLCRVFDFLQIASLQAYMFYQLKSFDENLSDSDVATQAGILQGAFTAAQFATAIPWGRVADAEWGGRRFVLLVGLMGTAVSCLGVAFATSFAQAVFWRSFGGAINGTVGIIRTMIAENVKEKKYHSRAFLILPIGFNIASLFGPVMGGLLADPVKSYPHLFGPNSSFGGENGVQWLEKYPYALPMLANFCFLSICATLVGYGLEETLLSRKGKPGLGSLAMKLFARSVRTVVGTSSPIYSKLPFRDYDEDGPLLGRQMDCSESYELEEKASKPVRVKRTLPFRRIWTKNVLCTLGAQAFFDFQMGAFNNLWLLFLSTPRYDPNDPASPAQSLPFIFTGGLGMLPQSVGFATAILGIIGMFLQFTIYPSINGRLGTAKSYQYFLSLFPLAYALAPYISLAPSSIPPPGQANGPWVWFWIIIVLFLQVTARTFTLPTSIILLNNCSPHPSVLGTIHGIGQSVSSAFRTIGPIFSGAWYGYGLDIGMIGFAWWLIALVSVFGCVAAFFVHEGSGHEILLPGEEDDFDHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1X2</accession>
    <name>A0A1Q5U1X2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Winged helix-turn helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1X2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1X2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10545" checksum="5BC631F032B901CF" modified="2017-04-12" version="1">MVLVPKVQVALCGHLLEKPALYLDEIAIFLWDEFALRANKSSISRALKSKGWSKKAARVEARERLENDWSDTRGSSAFMWRFGAIFGWTTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5B0</accession>
    <name>A0A1Q5U5B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5B0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5B0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="734" mass="79028" checksum="5B8C9825C976F37C" modified="2017-04-12" version="1">MGKRASKKGSASGCQEDSKSRNSQTELFAGPSVTDATLQQSVLDLLRGIYDEGSGDLRSSVHRNKVSQAIRDRMDKMQGEIQIHSDSRDSVVDILYTMFKLLQAQWKKQGPSKSSKQPEPPAPSENPKPATQLENTQPPGSTFDQTGLSVVPDADVQIITHDNPGQPLPVRLSDLLPDSNDLTHRTLNGGWTQLGTPQEGETRLTSINPGSTVIRVITTYYPSHRNPSPDNVDGNPRSPLPRPSFKIIIRPQAISGGALVSQQPELARPGTTRRGSLDTSPGRSRLPPRTATGDPGARPTISEVPGPQRDTPKRPLPASVTTEPPVPSTSAGPTVPSVPPPVARRIPRKRPMAASVQNAPGFDLTIPQSAIDALNAPGPGSGWFEYDGLVIVPRRSPAPETTQPAALPTAQPTAQPTVQSTANPGDRRRREIDDEPSDRPTQRRRLSDQGSSRPDPSKESTDISMFDASSLPDTIGLAETRRLSDSLGWPAQPNWAAQPATWHSNVAECASKNAPTCEEYAADILRWKVAHRSSQDSSAVGQYIPPVAELINEVVPSAGPDLYEQVGEPWLGMSERRMPPGVQGAIASRRFSAEITQGTEQIALTGEPEQPFASRVPLTVTSVPTGPVPAVPRSADDRISAVRKPRRRFSEHQRRPNDSSSSDSQVSSRKKRRLNMSPASSSPSPPKGKTTKFHVCRPGLGQCGRHVKGGGASFYYSAITIDSFITTCNPGTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U6Y2</accession>
    <name>A0A1Q5U6Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">NADH-cytochrome b5 reductase 1</fullName>
            <ecNumber evidence="5">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Microsomal cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PENSUB_5613</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U6Y2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U6Y2"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 25" id="KW-0274">FAD</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 26" id="KW-0349">Heme</keyword>
    <keyword evidence="15 26" id="KW-0408">Iron</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="27">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="28">
        <location>
            <begin position="225"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00039438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OKP08246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="468" mass="51163" checksum="4032EA5B65F8CE71" modified="2017-04-12" version="1">MATTETTELKAQWKAEVVLPEYSMQEIAAHNTKTDTWIVIHGQVFDITEYLQDHPGGAEVLVEVAGQDATAAYEDVGHSEDAREIMQPYLVGTLKDAQQYVRPKAVRVVSQSTPETPKTSSIGTVAVVAGTLSAIIPAIYIYSSSTHFTNGLTSISHLIRLPRGGFVNGFLAASLICGTIGVYAAKQASRFTKIDSGFMRYPPRIKSKKVIRVDPHLTRGFLEPQTYQDLPLVAKHQLSPNVYRFVFGLPDPTTVLGLPIGQHVAIKAIVDGATVTRSYTPTSNNLDRGRLELVVKCYPDGLMSRYLSGLEIGENVPFRGPKGAMKYTKDVARHIGMVAGGTGITPMYQLIRAICENDADRTQISLVYANRSEADILLREELDAFARRYPGNFKVWYMLDTAPGGWNYGTGFVDADVLREHMPAPGPDTKVLLCGPPGMIGATKKNLATLGFKKPGTVSKMSDEVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U794</accession>
    <name>A0A1Q5U794_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U794"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U794"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="250" mass="27803" checksum="18E970AB7FA23B09" modified="2017-04-12" version="1">MTRSLRIAVLECDTPLPAITDRLGGYGEIFARLLNKGLKESGETTVEIQDVSKWNVVNNPVFPEVNEFDALLISGSKHDCFADDPWIVSLTEYVRGVLEEHKKPVVGICFGHQIIARALGSRVGRGDGGWEISVDEITLTDAGKELFGKDKLYLQQMHRDVVHEVPEGCVNLGYSPRCAVQGLYQPKKIWSVQAHPEFTEFIMSNVLDARHKNGVFNDEMYEDAASRAGKPHDGEFLATQIIKFIAESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7B2</accession>
    <name>A0A1Q5U7B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7B2"/>
    <dbReference type="OrthoDB" id="4345400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="228" mass="25555" checksum="DB230C8E87613C43" modified="2017-04-12" version="1">MNPSANYALSSVRKTQFLIAGFSLPCAIAAVIDKHGSAETILQLTWLIISMCASLLFLFNRRKATTQQYPVYEILGDLSLLILFVGVWIAGIVILAVKEVNHWRATYALGIPHIYTNLSCLIMWLSYAYTFFISIYRRYLAQLSKAQCWRSWGTTYVQCPSCDRSASALMGSNARWSREISERGANSFDNTPGLYTDDEAEAQTLLRGDTHEATKQETGTIKLTNDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U8Z8</accession>
    <name>A0A1Q5U8Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000560">
        <property type="protein sequence ID" value="OKP08912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U8Z8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U8Z8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP08912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="17437" checksum="A4BA700886F3AF09" modified="2017-04-12" version="1">MSAFMGATPLQVVAWTVPMAVGGLILSVTGGFILHKVSGTVLMIISCLGYVGSGLLFAIIPLGGNYWAYVFPAMICGTIAIDISFNLANIFITTTMPKAKQGLAGALIYCTMHMGIAVMLGIAGIVETQTKYLETFKSHYDSLRTLLTEKDFDAFSNGRAFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA12</accession>
    <name>A0A1Q5UA12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA12"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA12"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="39848" checksum="C052F98454AACE18" modified="2017-04-12" version="1">MAQFTMGSFARWSSSMRLSVATQTRSYASKSAIPKFSSTSSPELDQLLYRFREDRFIPSGLPNQQRRNMFKEKHRQRLEDEPITVAISETEDFTLRPMRINELPTKKDAYEVLRLIAATNEWKALVPFLSGMYMSNLRLNTNRFAQIVRKASEAGKLPVIMECIRQGHRTGFHLRDLTVVQRLFYDIHILAQSADFKGPAVTKALNMAKQAVDLMDQDVETHTSLARAENPKHQPFVIGTLLELSAARAINEFGGKDQANEVLSYARKLVVSWPIVKEQGELAGGVSSASERAQQIIAVYNGLRLSLSIHGLALDNTLHDSVTACLTEAKTELESLVDTVEQTHVQESVRTILNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB54</accession>
    <name>A0A1Q5UB54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB54"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB54"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012502358" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="266" mass="28460" checksum="979D8AC00CCFC017" modified="2017-04-12" version="1">MVLQQLSSRWATLIVLLWATVAHAHTVITYPGYRGNNLQTNGTVAEANGLGVAYNSKNDSLYYPYGMEWIYPCKHPAIMSPNRLRAITNNHSLSSGGGMPTSTNRTYWPVGGGALALQPGWFPGHSTALIYVNIGLGEVPENMSHPVVSPFQITGPTNNPYPGTICLPQVPLPANISVKAGDKATIQVVETAKHGAALYNCVDIIFADNGDSKIAEVNADNCFNSSDISFQYVYTTSGIGSGAAMLQPPRQVWLAVVPVLLVAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC14</accession>
    <name>A0A1Q5UC14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000400">
        <property type="protein sequence ID" value="OKP10028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC14"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF14">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="293" mass="33197" checksum="1941229EC6EF46D5" modified="2017-04-12" version="1">MSGLRVSVYTVPPVACVDHVSHQQNTTWSPESCTLVYSENEAVLVDTGITINQNKELIKWIEETAPGRKLSYIYITHGHADHFLGLPLLLQRFPEAQAVATEATVRHIEQQISEPYFSSTWVAFFPGGQLYTPQQPPKVLPRDNKFVLEDRWTFEAIECGHSDTFDSTILWVPDLRLAVCGDVVYGDVHQMLFEANTPEKREEWIRAIEKVESLNPVYVVPGHRNANEMDGVWHLESTKRYIRDFIDVLKEKPQTVTELFSAMIAKYPNRFNPMVLGWGCAGAHVSGEVPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC61</accession>
    <name>A0A1Q5UC61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low-affinity iron/zinc ion transport protein fet4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC61"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC61"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="500" mass="56203" checksum="F93AB67E4367C68C" modified="2017-04-12" version="1">MKSFKPVFLCEVKGAAETQQVAKLQNAKNDINTAVVAENVSGYRIKGSSRLVDRWLDKFVKFAGSAPVFLVIVSGLLTWALMGIRFGDSDVWVAAISDVQAILCYVFDSLLMRQLLREYTEQREAMVEIMSRCNSHHRMLLKVKNKLGSEGIRQISEKCQDEPLEPLDHGLRTQSLFARCIIFSAKKFGHIITVGMYWVCIFIWLGFGPKCDWSDRWQLYINDATSALMVLVFAFLACLRECYADYTNTCLDAIFRLDSTLESELRLLSEDDVPNPVEVDIPAKENYLQKVIYYYADIVGTLVGILVLVAVICTWAAVGPVFHFNNTWWLLIGTYAGLVGLFDSFVLRNVQNKVHQNTKCQVRHVEAFDTTLFAGLSVPIPAVKDPKAPSLSRRVSRKMDAVSSHLLMVVAGFVVTIGCLVASSAMRWSLTGQLISNVPPSIIETFFMLILITGQNDAEAGARVDLTNIYYRRQRLLSFMKHASDYCQKHDESEPATDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCN1</accession>
    <name>A0A1Q5UCN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCN1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCN1"/>
    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="400" mass="44257" checksum="9FDC287F0BFD0548" modified="2017-04-12" version="1">MLGQTQRPAVRVIGRVRCQVKPRVSNARFQSTSSGPATSGANSALIGGVAGGAFAAAAGYAWYSFSGAKTLVDTNKQAKQYLEQAKQKIAEAAPEPSESYAWFKKTVTRYAVFIPGAREYVDTAFKDLEKIKDKHGDEFDKVIQDAYKELADVSKNGGFDSDTAFAAFHVLQKHLDRLLDLAGDVGEDILDNHPKIKEKLGGSFDQLKQMGDAYGPQAKEEVNKTWNQVTDIVKRGASIDAVAEIKKLIDEKREKLQKLGDEAWQKGLDESRQFLEKNPKLKSLVDENADALKKGNFQDLWGLLKDSASSGKTEKVEKYVKEKVDQVKSGGFGDLDKWLEAIPGGSNILPQLQTLQTVAQKKGDEAEKVLKETFEEIQEVLKKRKEQVEKIAEEAKEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCU1</accession>
    <name>A0A1Q5UCU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000366">
        <property type="protein sequence ID" value="OKP10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="317"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="396" mass="41892" checksum="E3636A25295685A9" modified="2017-04-12" version="1" fragment="single">MGRWWGLPLPPEIVLELFEYLEPSDVVALAQAAEGFAELAVSAFSSSLREHGRTILFSAVVCGHTSIVKRYLEAGADPCTADDKGNTPLHWATAFGHCNVATLLVDVGADINARHKNGLSPLDYAIITGNDRVVEVLLNKGATITDVRIGRAQRTTLHAVAIKGYSRIAEMLLNRQAPIDANDAHGLTPLHLAVSEGHLEIVRALLCAGATVDIQDEEGDSPLHLAAGNGHIAIVQELLNRGADPSLQGHENATPLHRASLLGFVDVVQCLLEAGAKVSAQSLVGQTPLHQASGAGEEATVRLLLDAGCGPSIPDKSGATPLHFAVLSGKGTIADMLINAGAHVDSINDNAQTPLHWAAKGHEEMVPTLLNHKADLHALSHTKWTPLHWAANEGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDC4</accession>
    <name>A0A1Q5UDC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxyacid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDC4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDC4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="20600" checksum="A4550D4638E743E0" modified="2017-04-12" version="1">MTDREKEARIVRRAEASGCKAIFLTADSPVLGVRYNEWRNGFQPPPGLGYPMIEKTSDQIQQESHDDGFSSFNSDSHSWAREIPWLRSITKMEIWIKGVLTSEDVETAIEYGCDGVIISNHGGRQLDETPATIDVLPACAKAARGRIRIHIDGGIRSGTDIFKALALGAECCWVGRPMLWGLAIAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFF5</accession>
    <name>A0A1Q5UFF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFF5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFF5"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="263" mass="29472" checksum="B2F70B3179AEEE87" modified="2017-04-12" version="1">MPPKSGKKTAAMPYPQGKAGSNKKAAKNPLIEKRSRNFGIGQDIQPKRNLSRFVKWPEYVRLQRQKKILNMRLKVPPSIAQFQNTLDRNTAAQTFKLLAKYRPETKAEKKERLTQEATAVAEGKKKEDVSKKPYNVKYGLNHVVGLVENKKASLVLIAHDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHKKTSAVLALTETRAEDKAEFSKLLSAIKEGYTDKYDESRRHWGGGIMGAKANARQEKKRKAVENAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFY1</accession>
    <name>A0A1Q5UFY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_3066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFY1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFY1"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012772975" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP11374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="24709" checksum="6C22A0D4D6EFB43D" modified="2017-04-12" version="1">MKFSSFLTTAALFSQSAVAHYKFPALIVDGTPTPDFKYVRFNTNNINPILDLNSIDLRCNEGGLASGPQTETAVVQAGSTVGFTLSNSISHIGPLLVYMAKAPGDPSSFDAAGDVWFKIHEWGADFSSGSINWPELGLMSYTFQLPPSLPDGSYLLRIEHIGVHNAANPNSAQFFVNCAQVQVTGGGNGNPGPLVAIPGLYNNEDPGIHFNNYYPPPTSYIIPGPPVWFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGT9</accession>
    <name>A0A1Q5UGT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGT9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="270" mass="30118" checksum="FA64F14B208FDBB3" modified="2017-04-12" version="1">MIREKGDILIHAGDLTAKGTFDEIQAQLRWLSSQPHRHKIVIAGNHDILLDEDCDAKFVTRLEDGVHQRKNLDWVDIQYLQDEAITVSIPIQITDDEISQQQGQVRKIKIYGSPSTPECGTWAFQYPAIRDVWTGRVPDDTDILVVHGLPALYGDCDGETETSGEVRVKGDGYLLREIWRVRPKMVVCGHIHGAFGVSVVRHDRVQDAVDGLRMRWPEHGVLGALQRVFWSGIGTVRGVDSLKETVVVNAAFAGGAFETEDKGAIAIDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGX5</accession>
    <name>A0A1Q5UGX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGX5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF3">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30431" checksum="206283D9D2FC9B82" modified="2017-04-12" version="1">MEESTEQKRWRDPFAGEPPNDPTRTLQVIAAGLPRTGTISLTLALSWALHGDVCHGDIIKGWTKVLDPGKNVSQEEVDDTLKELLAGYVATTDAPAIFFVEELVRLYPDAKVICTVREPNRWWESYQELINTLDNPLFILLQLVQPTLRYSLAWKLAILKRRRKIYPPEFEPLGPHFMEIHSDYLKRVVPEDRLLFFNMKDGWEPLCKFLDVPVPEKPFPQVHDRASMKSSWAPYWWRDPDRVLRTHNNSISSQARAASLVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHK4</accession>
    <name>A0A1Q5UHK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein STE50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHK4"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="387"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="493" mass="54596" checksum="8036CF0882170917" modified="2017-04-12" version="1">MSLQTSMYHADSDADDEYERSVITSPHLQTDSEASPTDSDIASSEHTPTKFGSEGPRTPRTVISEWTADECVDFLTSLGLLQYCGTFRENGIVGEALIALKHDELKEMGINSVGHRLTILKSVYEIKIRQHVPLDVDHYIPLSADQSMNENATQDDIARLIQSIQRRDEKIMMVEAEMHRLAEDYRRLREEILPVIKIAKDRSQPLPPPSSLGTSSDSYHDTATLTSPSQLTLVDNSTTSKLHRAFSKRTYTGGTTPKNNSPTHIPPSIYESRNYHDNQNLDPSAAAVAASSHLSASVNGGLQHSPAVPSPTSPNAHTSQHQTLNPRSYTQPSSGRSMHDHSDDIPQRTASRADRLTPREQPSRTETPSGSRESSAPPGQPSSVEIFKSFRVSWDDPCYKVLPAALKKYNIHSDPKLYALYIVYGDQERCLALDEKPLILFKQLEKEGRKPMFMLRKIHPDNPTYPIPGSAPNSAGFESGRPQAQINLPGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHT5</accession>
    <name>A0A1Q5UHT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHT5"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="363" mass="39530" checksum="4B371BA6C5325775" modified="2017-04-12" version="1">MPNKIVVLGAGVSGLTTAYLLSKDPENQITVLAKHMPGDYDIEYASPWAGANYMPVGKQGSNHHAWERDTWPALKEITEKYPEAGIHFLDAIIYNRKKDQETATGKWFSELVQPNPWYKDVVPDFRDIPESQLSPEIDNGQIFTSVCINTAVYLPWLVGQCTKNGAVFKRAIFRHIADAANAHHSGQKADVIVNCTGLSSKFLGGVCDENLLPARGQIVVVRNDPGPMIGLSGTDDGEDEALYMMTRAAGGGTILGGSYQKNNWDALPDPNLANRIMKRAIAIAPQLVKEGEGIEGLDIIRHGVGLRPLREGGPRVEKDEVAGVKIVHNYGHGGFGYQASFGCAETAISLVKEVLQNKTRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHU1</accession>
    <name>A0A1Q5UHU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="284" mass="31262" checksum="A46195C9FB10BAAA" modified="2017-04-12" version="1">MPAANTSENNHQEPSAKRQNVLFVVPNALDSGGIDIFHLPSERRLTTIKSDPSVKTGMLMAVSIFISPLGDIFVASAFEDGHVMLFMHKGPLNPASFELSNINSTPWKWNKLYASRPHTQPVLSLDVSPSRDYFISSSADALLIKHPIPAPGSAGFISAGNYIEDKALKTVNTKHSGQQGLRIRNDGKVFATAGWDSRVRVYSGKTMKELAVLKWHKDGCYTVAFGEVNSLTSEPSNGQESTTEEETPQRSLATVHQQRSQKIQQTHWLVAGSKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI29</accession>
    <name>A0A1Q5UI29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI29"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="30668" checksum="159F350DDE6FA5BE" modified="2017-04-12" version="1">MMEDFNSETDSDYTSYWRDWFVSSRGNEYFCEIDEDYLTDRFNLTGLNTEVAYYQYALDLVTDVFDLDADDDLREQIEKSARHLYGLVHARYIVTTRGLAKMLDKYKKCDFGKCPRVLCDGHPLLPMGQHDLPNMSTVKLYCPKCEDIYNPKSSRHASIDGAYFGTSFHSILFQVYPALNPEKSLRRYEPRIYGFKVHAAAALARWQDCCREDMQDRLAEFGMAHKFVEESDSEEENFEYGEENEPVKTEKIAGDAASGRMDLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI35</accession>
    <name>A0A1Q5UI35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI35"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI35"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20760" checksum="4EC420DBACC9302D" modified="2017-04-12" version="1">MRFSPTSTEPLYDILPWVLRGHHIDVIEILRFPAISEILNNRHPNPSAVIPNLSSVSSEPTSQLSKEYLENAVRRIEANTEGLLHRHQGSWLTIRSCTRSALALLAMKLHYQSESHYGNNVPEDNRAYQSTPSPGSLQADSNLPSRWRDAVMLVISMLKGWEPESPDIYQLRLVVEGLLGLCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX9</accession>
    <name>A0A1Q5UIX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11337" checksum="10BB0F78C3A91AD8" modified="2017-04-12" version="1">MRPHLLQVLSKAPAPGNRHVELYPRPINAHRKYVAGQSVKVHLSRSISERCQQHNKHSDVEGTTRRGCDRSCSMWSITSVDPLAMQVPTGGLSIRADKWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ48</accession>
    <name>A0A1Q5UJ48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ48"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013248285" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="65" mass="7608" checksum="3510E637BFA96A70" modified="2017-04-12" version="1">MAVAGNTQWWLGHAWLRNATCQPLFGRWLWLVRQATRGLTIVRGSRSYFCEDRPLTTPVEFERSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJQ4</accession>
    <name>A0A1Q5UJQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJQ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJQ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="3">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="298" mass="33847" checksum="F8ABD6FBEBF90FBE" modified="2017-04-12" version="1">MAGTKRKLNEITAEQTTQEQVEEPSQQVQPSISTSTPPQTDLPSDLNLESPYEILIHFIGEEIFQRISRSTNEYVAQQDQSSSSYTSRTWKDTTIDDIKVFFGLLIYMSVHIAPSLSYYFNTDWHPGPLHPSRHYMGQKHFEQIKRNLRIPLPLPGQVQRGNQSSTLSFDGAAPDNDEPGASFAKALLARGPWDKSLEEELDSPEAIHDFIGRHCAEPGLINRNRSAFKIFGNPRKFPAPLPFPFLEDALMKAWQIQRTHKKQQGVKASKLPTTLDFREDLSREFFAFAGRPQPPPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK23</accession>
    <name>A0A1Q5UK23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK23"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="197" mass="22161" checksum="43EEECEE63FDBAD3" modified="2017-04-12" version="1">MVSTTAATAATTSFVFPSTYNFPPFFTPQPNSTTRHSQLQKWSSLIQSWCRHHRTYRLSLVDAVDSPLFHNTALRKRLALAEARAVVDWMTKKEEEGGGGQRAEWIEAGGNTAPKIVAWIWWRRPEEWADVLVDWVDATGQKGVVLTVFELLQGEATVSQEFHGMDNDVMMKSLNVLVKRGKASVFGNEGEEGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK38</accession>
    <name>A0A1Q5UK38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK38"/>
    <dbReference type="OrthoDB" id="4304815at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="216" mass="25058" checksum="6ED7FDF4667B8E3F" modified="2017-04-12" version="1">MQSRYDPREDAIGPFDVDPNQKSQSKAKGREPPLFPMTPEQFQEIRANFGAKFKEWSSGSSGKTTADMAEILEYMVDDFDHFKTAADPISTARCFPRKCELIKHEVLRLIQRLKSIPKLDLETEEIMAYIRSAILRLTIEGKSDLVAITETERFERIHQHSVWDMPELGWGKEAEGLRTRLWTVYTNVNFSRADCCFQCKPYWFSEKAPEIRRGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK79</accession>
    <name>A0A1Q5UK79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK79"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000002">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF222">
        <property type="entry name" value="MALTASE MALT (AFU_ORTHOLOGUE AFUA_8G07070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="20"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="583" mass="67220" checksum="354C6BF418B5B4A5" modified="2017-04-12" version="1">MPHPVRQHEPKWWKEAVVYEIYVSSFKDSNNDGIGDIPGIISKLDYLQDLGVDVLWISPHYQSPQVDMGYDISDYQQIHEPYGSMQDVDTLIEQTHARGMKIIFDLVINHTSDLHPWFQESRASLDSPKRDWYMWRPARYDAADKRCPPTNWRSNFGGSTWTWDEQTQQYYFHIYAPGQPDLNWENPECRRAIYDNTIRFWLKKGIDGFRVDTVNRYSKCIDFVDAPVTDPNDETQLAFQNFTNGPRIHEYISEVRSVLADYDVFTVGELPNTPDEADVMPFISAREKQLDMVFNFDTVYLGQTPGDRFTLQAFSIADFKRELTKWQRVIQDTDAWTTVFLENHDQGRSVSRFASDAPAYRVRAAKMLALVLGTMTGTLYLYQGQEIGMVNAPPSYPVEDYKCIRSVNHYNKIHRQTGGDPVALSHAVDALQKVARDHARVPMQWDDSPNAGFCDAQTTPWMRVLDTYREINVANQVGREGSVFEFWKNAIRFRKQHKDLLVYGRFQVIDQHEDLLVFVKEAADGKVSLTVANLSDQPREWTLPPSLPRVNPWNLVLATCNAQELQQSQLAAFEGRVYVSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKB3</accession>
    <name>A0A1Q5UKB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADPH--cytochrome P450 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000171">
        <property type="protein sequence ID" value="OKP12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKB3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKB3"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF108">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="84"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="275"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="703" mass="78633" checksum="3FA43B0B2EA144AB" modified="2017-04-12" version="1">MELKAGTSSLPFPSRVILLESLRIPDILTVILFVTIWAWFTDGLGFWAPKPDPMLFLPVRDRSRYKMLPKKSRNITETMKDSDVMVYWGSQSGRAERLAARLARECTARLGLRVAMADLDDDDHEHLSKVPSSKLIVFVISTFGEGDPTDNSVAFCSMLRALRATGNTQLLTDLRYAAFGLGNRNYRHYNKIVDLVDTTLQELGARRVGTVGKADESKRGAATDEDFLEWSNSMLESLGEMFGVEKRPMVYSPELEVVAADSKTEVMLAREAQSNINIPAAVVAARVLTNGLDRRCFHLEFDLSSNRSIKYQTGDHLLVWPHNSVSDVRGLCRLLGLGEMERTQPIEINSRLQGGNYSTVFPSPTTKETVLRHYLDISGPVSRDLLRQLAAFSPTPAAGEYLLALAKDKTKFHRTVSLGHLSLANVMQLASSDQVWNQLPFTFLLECLGKLQPRYYSIASSPSVSPFQPAITLAITRKAFFASSCGAHLQRSHFHGVASNYLLAVKRSQNSSDNSNSQQPLDEGPDYGIINNQVLVRIRRSTFKLPANPQRPIVMIAAGTGVAPFRAFVQERAAMAARGLPVGGSLLLFGCRSPTEDYLYENEWRDHVATLPGFEVINAFSRYGEKKVYVQEKLLEVKDKIAGLLEKDAAVYICGSEDMAREVRRALMKVVMEMRNWTEEEAERYVMEDMKKAKRLQEDVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKB9</accession>
    <name>A0A1Q5UKB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase assembly factor FMC1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKB9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKB9"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16392" checksum="33642A6EDF732379" modified="2017-04-12" version="1">MTAPLTNRARSTYRALLRELPRGRHTTPSPLHQRLRVIFRSQEQTPSTPSAPTPSHTSSVASSTQPIAFSIPSSEEERALRIQEAEQLAQYAKAQRTYTELLERYNPGMNMEEEERIRLTARRVGFDLPELHNPEEGGNQNPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKD3</accession>
    <name>A0A1Q5UKD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras guanine nucleotide exchange factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKD3"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="445"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="700"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="259"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="953" mass="105725" checksum="D40502B61E5918F7" modified="2017-04-12" version="1">MSAQQTRHARASSDRAQTMPPGVPQRPGMGSRTSSAPEGGLYKLDAGRRPTSAAKVGHTLLEEDEGSSSTSHETPKRSRSRRRSEEESSKSSLPEVTIAVVGEDDAGKTSFIKSALDMKGTPSSVSTKKKMSLDGSVYIVRLLEIDLKQVTFDQDLNIVWPRVGKDSAGPIVDGVLLLHDATQPERLEKTVELADALDDTTVPCVLVACKCDQLPEDGELGPIHERHDIYRTSPESPRSQQMCIALVLRSVIGHRADLAASDRSSNPPPPSAQPQHPPFAPPPPRTTTKSFQPNPSPPDWHHTRANSETPSVVLSGAAGGSVTSVSDRTVDGNGVHRLPTDQVHPSNLAQQHASSSSRNARSNSHPVRPQTPPTGARLNPRRPSAQGDLSPTQEHIRQRLQPSWRHSGGSDAFNSFLNMEDEMDDGAQPASPGAVLRPKPSSESNSSAEFGLSFDELVDRLVALPMSKQDSKFSAIFLCLYRKFAAPSTLLNALISRFEKNETSNVDQLARMADQLRLLNVIASWASEYPGDFANPKTKKRINEFVMNLEKSHFYMFAAKEIGSYLDTNAEDDDIGWAFGDGDVDESTLTETFFDNSGRSSPVPFMTGTYDDDDDDEVEEDPIYSSMSALDLSGEGPHDSTSRLSGTLSISSNTDKPSSTMNQSFTLLTVEAAQKEALRLEMTGRTSLTKIQWRYFMETPDEEFARELTRIDWIMYNSFRPRDLVRHVSISGVDKDKIKSLQNVNRMIKQFNHVAFFVASMILLRDKPKHRARCLEKFMSIAVKLRRQNNYNALGAVIAAINGTPVHRLTQTREMIPVASQKEFMRLVILMSTSRSHSAYRLAWDNSFSERIPFLPLHRRDLVSAEEGNKTFVGENKSRINWKKFEVMGEVVIGIQRSQKSPHPQAQKYDDIERLVLDSKLSGDEEDLYARSLQLEPSTGSETGRRKFAWLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKR8</accession>
    <name>A0A1Q5UKR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKR8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKR8"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="144"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="56223" checksum="6A468475644B4625" modified="2017-04-12" version="1">MADFVDPRMSSIKPRIRYNTIGGINGPLVVLDNVKFPRYNEIVSLTLPDGTERSGQVLEARGNRAVVQVFEGTSGIDVKKTKVEFSGHSLKLGVSEDMLGRVFDGSGRAIDKGPKVLAEDYLDINGQPINPYSRVYPEEMISTGISAIDTMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKRPTKDVHDGHEENFSIVFAAMGVNMETARFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVIMTDLSAYCDALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIFIDRQLANKGVYPPINVLPSLSRLMKSAIGEGRTRKDHSDVSNQLYAKYAIGRDAAAMKAVVGEEALSSEDKLSLEFLDKFERTFISQSPYESRTIHESLDIAWNLLRVYPKELLNRIPKRVLDEFYARSARKIANKDTRDNSGEQQQSSNLIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKS5</accession>
    <name>A0A1Q5UKS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKS5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKS5"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="170"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="638"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="763" mass="86775" checksum="D7390052F41A032B" modified="2017-04-12" version="1">MPKNRPATSGYARLAQEEEERGYLHDDSEDDDIAVASSTISASAPRYAPISSRAQMQASGLSTPPGHRRRHSQYQRRGRRNSGVDIKAINARLERWADEIASKFKINRVKGKTFEEEKLEIYHSVFQAPPGVRAVTAEELESDEFEGQQRRARAEFEEIIESVRLAIEMDVHPRMIAQGSSGSYFARNPEGKVVGVFKPKDEEPYASRNPKWTKWVHRNLFPCFFGRACLIPNLSYVSEAAAYVLDARLRTNMVPYTDIVYLSSKSFFYDFWERRKAWKGKKTLPPKPGSFQVFLKGYKDANIFLREHPWPDQTNTGFRAQDAPKRKKRPWNEACRPSGAQSDDEDEDENGYMPSPNPRDESRERRFNWTENLKQSFREELEKLVILDYIMRNTDRGLDNWMVKIDWGTEQVSIVADPPKSTEPTPKHDEDELMPPPRPVSVNSNGSHPYKRQETMMAVSRTGTPLASSEQQASVSVGAIDNSLSWPWKHPDAWRSFPFGWLFLPVSLIGQPFSQKTRDHFLPLLTSTAWWSGTQMALRQVFAQDDDFKESMFARQIAVMKGQAWNVVETLKQPDHGPLELTRRTRVCVWDDLVDVPVAIPMRAPSMDAQRRQAMNYDYDEEEEMDIGAVISSNAPTNHDLLGLDSAPSDLPNPNRFELNRGQSDRESAASPTNDGDFARRTGDGAYARSLDGWPSLPARPNKHRKHGGSVSFRVPHVNTFGSDDLEGDLGYAAAEGMEGNQRKVIVERLEAVKSKNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKT7</accession>
    <name>A0A1Q5UKT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKT7"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000042">
        <property type="entry name" value="Putative exoribonuclease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="41155" checksum="F68FA46E2EEB05C6" modified="2017-04-12" version="1">MSNQRQASSASQVPHISPAELSYLYTSLSLPKTPIRPDGRSPTQFRPLTAETNILPGTNGSARIGFADGTQAIVGVKAEVEKTVLSNEMLARNDGGAGHEYGDQEGSAAAVGGHGSWVQMSIEIPGFRDDDALPVFLSEMMRESLVGAVGTDETSDMTGGLKGRLVINKRWHWRLYIDVLLLSQPLAYPLPLLSLTTHLALLSTKLPKLKSQGEEDPFFDDDWAVAEYLYPRPSLSSSGKKSVRSSFVRPPVTLLVISVGDNIIFDPNREEIAVADAVLAISITRDSEAGNLKLLAIRTVDPPSRLTQPAVPNSENVSMLGAVAPTEDVAVLNPATGEEEVPGVWRPRRGGVKRSVIAEMVKTALKKGGVGEEVLEGLEGVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKW5</accession>
    <name>A0A1Q5UKW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKW5"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="332" mass="36540" checksum="503F9474EC800499" modified="2017-04-12" version="1">MDYEMDLEPAGPQVTVREVEPYRVDFRLSSVDLAFANSLRRVILAEVPTVALDLIEIENNTSVIPDEMLAHRLGLIPLNAKNCEQDLDYTRDCDCEDHCVRCSVTLSLHVRCESGIMSVYARDLMVQGERMNDTIGDPVITDPEGKGPLICKLAKGQEIKLTCLAKKGTAKEHAKWAPTAAVGFEYDPHNNLKHVDYWYEQDPIKEWPISENAAWEQPNNPDLPFDYDAEPNIFYMDVESIGNLEPDTIIQQGIFVLQKKLALTVSELTGEGENGHAGGPEDAEMMGAGDADAYEPPEGIDGNMGGYGGASWGASAQTPYGATPYGQSTYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKY0</accession>
    <name>A0A1Q5UKY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="11000" checksum="F54A22FC2A7A87BE" modified="2017-04-12" version="1">MSKISLVAFQAVDIRGFSYTLYDGDNNGNDGVLKDKPRRFKAFSMIFAGLSCNSATSVAPKLEDFAKPGRFPPLSLDSNGSGTSLLGAIPFGASNAIVEFTMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL43</accession>
    <name>A0A1Q5UL43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL43"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL43"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="589" mass="63995" checksum="D16B1F852F070292" modified="2017-04-12" version="1">MRLQSGASVAAFAAAASAKSLADVCTLSNVKSALPPNGTLLGINLIPSSSTAAAVYNATTGGGMTSTISETYSYCNVTLTYTHPGKGDTVVVKYALPEPSDFKKRFYVAGGGGYSLSTDATGGLEYGAAGGATSAGYDALNSVSYDDVVLYGNGSINWDATYMFGYQALGEMTQLGKYFTKGFYGLSSSSKVYTYYEGCSDGGREGMSQVQRYGEEYDGVITGAPAFRYGQQQVNHVFSAEVEKTLDYYPPPCELAKIVNATIKACDPLDGRTDGVISRTDLCKLHFNMSSVIGEEYYCAAETSTSLGFGFSSKVKRQAAGSQTSYQPVQSGTVSAEAVAVAQAIVDGLHNTKGERAYLSWQIGSEFTDAETEWNNSTQKWELDIPSTGGEFVTKFVQLLDLDNLSDLDGITYDTLVEWMNTAMVRYMDSLQTTLPDLTPFQSSGGKLLHYHGESDPSVPAASSVHYWQSVRSIMYPDATEKQALTKLQDWYQFYLVPGAAHCGTNSLQPGPYPEDNMEIMINWVENGVKPSRLNATVSSGDYEGETQMLCQWPSRPLWRSNSTFDCVYDKKSIESWTYEFPAFKVPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULB6</accession>
    <name>A0A1Q5ULB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULB6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULB6"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="358"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="624" mass="67808" checksum="889FDB69907B84AB" modified="2017-04-12" version="1">MFDQLPDELVIQIAKSLNRHDLNSLIRTIHRFARILNPLLDAFVNHTFKDRRTPLQWAAFKGSAALTQSLLGRGADIALQDWHGETALHFAARGGNVDSVKVLLQNGANIAQTNFYYSTALHHASLCNHADVVSLLLDSGADVSRPLYRTVLHRAVRGGHENLARFLLQAGADVSAEGPVEGMRIEAHDIPEAHHHFCDPNAEGAIDIIPGRLVDGPSPVTSLYYAVLEGHESITQLLIEYGIRISPRDHNLKTALQFAIRRGSSRHLMVSRMLIVTRPDVFVEIPGKWGLTSIHWAASRGYVDLVRLLLRRDSRTINGSETDGSGHVPLIEATKNGHGAVVKLFLEAGADPSTEDGKGQSALLWATKYGRLSVVKLLLDAGADHKAERNFSEIPLFVAAKEGHIELVRFLLQVDSNINLSQMTSSGQSIIHQPANRGYDHIVQLFLNAGVDASINNGYGSPLHKAATGRKTVTTIRLLLDAGSDISIKDENGNTPLEAAILAGNESVFTTLLEASSGICIHTGYRKPLLHTAAAAGRDTMVNLLLNIGGDVHLRDEFGTPLHWAARRGDAKSIKLLVEAGADSTAKDSAGKTALYWAAHRGVAASVLLLLQEGVKQRGRVEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULH3</accession>
    <name>A0A1Q5ULH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000135">
        <property type="protein sequence ID" value="OKP13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULH3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="20585" checksum="CB7CEEE3EAC5506A" modified="2017-04-12" version="1">MEKLHSSKINKPFRLGNEKSVRHILAKFSLWASARPKRSLRFTEQKSPCGNGKLLKMRQTASETAFVLSIISKKALHTFIKLPADMSLTLRLVGVAGYPLNGLRKEINASLSKPVDAYLEASRFEQGREEMHLSSTEERVEVLENWILIEVLHETDCKRRQRSVVKMPGLSNKSRGRQSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM74</accession>
    <name>A0A1Q5UM74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM74"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="527" mass="57156" checksum="6233236D4035E305" modified="2017-04-12" version="1">MKSAKGEDPREDTNSGPKVDLEAGHKQSTAGGPSKGAESKDVTLVRPTSPPFISLGYRQPQVTWNGPEDPDNPKNWPTTKKWRAAVLVSFFTFISPVSSSMVAPALERIAVEFKITDDVLLELTLSTFVLAYAVGPLFLGPLSEIYGRKIILQLTNLFYIVFNVACGVSKSTGQMIAFRFLAGLGGSAPLAIGGGVLGDCFRPEERGKALAIYGLAPLLGPAIGPIAGGFIAENTTWRWVFYATSITAGLIQIAGFFFLPETYGPAILGSKAKKLRKETENQNYQTESERQHQSPGKIISTALVRPFRLLTTQPIVQILALYMAIVYGTMYLTLATFPTLWTSKAYYGESAGIGGLNYISMGLGFMLGSQTCAPLIDRIYRHLKSRNNNIGRPEFRVPLMAVAAFCNPVGLFIYGWTAQTHCHWIAPNIGICIFSIGNIVAFQCIQTYIVDSYTRYAASALAAAAFLRSLAGFSFPLFAPYMFDVLKYGWGNSVLAFVAIGIGIPAPILLWRFGQKLRAASPFAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM89</accession>
    <name>A0A1Q5UM89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM89"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM89"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="19783" checksum="5C5B3CDE75A14D20" modified="2017-04-12" version="1">MSSSRVGFRFLNNARFAFRNASAPFRRPGAQGFRFQSSEAGAAEQQSAFQRMWNSPVGVKTVHFWAPVMKWALVIAGISDFNRPAEKLSLTQNCALMATGAIWTRWCLIIKPRNVLLAAVNFFLGCVGVVQVSRIFMWQRSQKGSSLEAAKELEHEAADSAKAVVDQAETAVKAAAEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN46</accession>
    <name>A0A1Q5UN46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN46"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013202792" description="HMA domain-containing protein" evidence="12">
        <location>
            <begin position="19"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1190"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1236"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="225"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="13">
        <location>
            <begin position="311"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1275" mass="138122" checksum="6297FB70BDF59EE8" modified="2017-04-12" version="1">MTMRRSLFWVSNIHCASCVAYVTEVLSEIPTVQDVDVSILTHEVRVSHGISVQPEHLAAALIQAAFEVYHVTTYDDRGAIVSELDTTSWNHRGSGFFSPRASYSSLSSNIKERLHNSREKGHIANCDACKKEQAQQFSPDSTQTEVGTFNEKSPRAPAWKETDDDGHSQQTTDLERSPTSAISHAAPSAATSETRVERPVDFSISIPPEITETARSTPSQTDDEFTARISIAGMSCASCVNSVTAAVQDLDYVREISVNLLTNSAALVYTGPRGNIDTIIGQIEDIGFEAFIDEVNPVPKLLAPQTGPRLYVTEIAITGMTCGSCVGAVTRGLEELPFVRNVSVNLLSHSGKIEFEGRENLDKIVEKIDGMGYEAAVNSVDTVSTTEQAYNPVQTRTISVRVDGMFCHHCPEKVLASLELLHNVTVDEIPTEKKPIIRVTYTPAPPTLTVRSILTAINEASSGFTASIYHPPTIEDRSRAMQLHERRRLLTRLLFVFVVAIPTFLIGIVFMSLVPSENATRMYLEQTIWSGSVTRIEWALFIMSTPVMFYGTDVFHTRALKEIHALWRPGSRVPILRRFYRFGSMNLLISAGTSVAYFASLAVLIVDAVVGTKTSAHSTTYFDSVVFLTLFILAGRFLEAYSKARTGDAVSSLGNLRPSDALLVENQSADTGASAGLGSDQMTRIGVDLLEIGDIVRIPHGASPPADGLVVSEASFQFDESSLTGESRPVKKAAGDQVFTGSVNVGQPVQIRITELGGSSMLDRIIAVVREGQSKRAPLERVADLLTSHFVPVITLIAILTFVIWLALGHSGALPIDYLDIARGGWTFWSLEFAIAVFVVACPCGLALAAPTALFVGGGLAAKHGILVKGGGEAFQEASRLDAIVFDKTGTLTEGGSLKVTEHEVLTKDEELLKVAWTLARKLEESSNHPIAQAISIFCQVQPMVNVMSSDIQEISGQGMKGIFTVTVENSGSGQQYEAAIGNERLLHSVLPDNSDTYFISSLLSKFQSSGKSTAILSLRRHSSETSSFVPAIVFATSDTIRPEAVDVISQLNKRHVEVFMCTGDNQTTAHAVAEMLGISRSNVMANVLPAEKASFVRQVQDGSVHSTTPSVGAQGPQGQMGTRSIVAFVGDGVNDSPALAAADVSIAMASGSDIAINSASFILLNSDLSTILQLVILSRRVFNRVRMNFGWAVVYNLCLVPVAAGVFYPIVSGHHQKMVGGEMITMNEHWRLSPVWAALAMALSSISVISSSLALRINMESVKRFLRWRRSERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNT5</accession>
    <name>A0A1Q5UNT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inversin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000117">
        <property type="protein sequence ID" value="OKP14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNT5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="32576" checksum="D34AD0E07B0B218D" modified="2017-04-12" version="1">MLAKNSTPVNTKNKNGRTPLSLAAWRGYETVVKLLVERDDVEVNSEDTWGHTPLSWAAFEGHAEVVKLLLRRDDVEADSKDGFGQTPLSRAAACGSEAVVKLLLERIDVEADSKDNDGQTPLYWAADSGNESVVKLLVERDDVDVNSRDCLDRTPLLHAAGEGQEEVVKLLLGRNDVEADSKNEFGCTPLLGAAECGHEEVVKLLLERDDVEADSKYLKGRTPLSLAAEYGHEAVVKLLLERNDVEADSKDTDGWTPLSWATERGHEAVVRLLVERDPERSPEKRTDCPQVQLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPZ3</accession>
    <name>A0A1Q5UPZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPZ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPZ3"/>
    <dbReference type="OrthoDB" id="4870562at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067157" evidence="2">
        <location>
            <begin position="22"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="403" mass="38697" checksum="007539360CC658BB" modified="2017-04-12" version="1">MKQTIITSLVALAASASSAYATDSLISVPVNLCAAILGEVECKQQSTTNGLINVPVNACVAALGKAKCDQASSSSSDGDSLISVPVNLCLAILGEVECKQQSTTNGLINVPVNACVAALGKAKCDQASSSSGNGDSLISVPVGLCAAVLGEVECKQQSATNGLINVPVNACVAALGKAKCDQASSSSNDGGSLINVPINICLAVLGEAHCHQSSNSGSGLINIPINLCLAVLGEADCQDCSTLTSTIVESSTIPGSGPTGSATATATGTGSETSTTAVGTSPSGPGSSPSSPSVTGIPVPSSGPSGAPGVSSPAGRPSSSAAATVTVHSTTTICPSGTAGLKSSSIRRVPSSAPTGPAGSAGSGSTGSASTPSATPAFNAAGRATLSGVAVFFGALCAAAMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQD3</accession>
    <name>A0A1Q5UQD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQD3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="469" mass="52325" checksum="ACAF22109AFD8986" modified="2017-04-12" version="1">MDNEVPLPPPRRIRHRSPSRLSPAGSVASSFRKSRRLSRFDDRSSQPSSDPALFSSDDIPASGLENYHAPVAGAGRKRRYRGTWWGEQVADPKRKRADFKEKRHVDSGVWMGSDESIAESSLPSEDASNWGEDLLKTVLDPRAPSKVANAPSLVKPSDIASVPVQPRPVVLQGPVETEEHKYAKAVINECLEKGDDSVDLGEIFDLKDLKVLSLRNNKLTRIPEAIRKLTALQVLNVSMNRLHELPWDLLWLLQQGELKHFTAHPNPFPSIDESGPVEWHCQFDKSNDEDKDGEIDEADAPEVTPVPIFSDYEGTPPNDAWTPIHVATGPVTRLDMEGRPLEPNTPFNTPSTSSQPASRAPSLREVSLRAISKLPGIDQLTDLELDEFPALVIPLISLARQARQDGAQHCSICQREFIVPRARWTEWWDCTPHENGMKRPRGSGEMLRPLPFKRVGCSWACVPGGQFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQS8</accession>
    <name>A0A1Q5UQS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ppk6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQS8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQS8"/>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60510" checksum="5CEC2074811BD906" modified="2017-04-12" version="1">MSADLLAEFGQGSGHAQGSQRPTQTARPSTNSLIDGFDQSDDVFFGDASENSQSRLQGPQVISQQSHYAPAAAAPRQPAAYQAFDLPRPHDSDVLFDAAEDTPASEADDDDWGDFEGPDATQQSQSQQSAVTPQSVQTTAPRPAPAAQASYNSGLAGTVDLLGGLSIAETTPDLVQQIQHPTGNPLSQPGWDDDSFGDWGEFTEAQSAKPVPPKSSQPPVQRNTLSKSLLEDDSFGDWGDFADGPSANPSPPKPSAEKRTSIKTATQKKTSISTKATPSIKPRAPIQTKPSTRPKPEQPAWEDDAFDDWADFTDGPAPSIPKQASSLPSPSPSTTTKPTPSPQSFTTSTPTIPITVRPTNIPPPSILLEHLLTTTLPTLQKSAQTAQTLPNTPQKHTTATQITNTLHTTARIIAGRTHRWKRDTLLAQSMRIGPARAGKTGGMKLSAVNKHEDVKEEQDAVDVLSLWRERAALFNAVVQAAGLKPIPVVSGPAVLKVVVVRAEQGGIKAGHACALCALRRDERIVRVDEEVVQDSFGEWWTEHWGHTGCKVFWEENRGLLMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR95</accession>
    <name>A0A1Q5UR95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR95"/>
    <dbReference type="OrthoDB" id="3940621at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="332" mass="38282" checksum="E4DD5E71E3BDF3C6" modified="2017-04-12" version="1">MRDDTVYAGIRPSNSNDPGRIILLSERVNKFIKLLTELSYTPCVPVGLIWRWCHHDGKAKESIRNPIEYRPDYEIVLMPFTQLSNWGYSISEDLSTVIVNESKLSKEPVAKRSMISLLRKHDPNRSERQYFLNTASDLVDSKWLFERWLTETRIFLDTRLDTLPGETAMLLRCRRLAHWFEDSTECKSQYEEQLLTDICNNLHIFMKHDPRLAQARLRHRSAILTHHQICAEKVDTNPRGVPICQPWDSSVWASARPDGIGTLSCAETMTNEVMIVFDIYSFLNEQIAQFLRDLHWWGCIPRMSLTRGGHGRLRVLGVKSLKGPAGGVKNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URN7</accession>
    <name>A0A1Q5URN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URN7"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="599" mass="66560" checksum="194D50156D43DCDB" modified="2017-04-12" version="1">MFGWGPGLGIPSASSEPEKERNPPSNPTPLDFPVYNLPDVVPHDADSTLPDLFGLLAAIKRPQDITIDRFKPLNVHLESDVDVRRMFPADQAQSLPPLPWEDESEVPSVAANQNQDQDKDKALPLMSNGVPYPPKDRFEILKNELSLDNEDTFREVARLPPREGRARVRVTQTRKFWTGLEHMAQYWDTSLDNYFERPASPTATTSVDGEGDELMDTDDASADLGEPGPAEPAMDVDEDESAMDTSPPSNGTDNEGSEQASQPMVKRYTGRRVGAGSEMPDEIRDETIRGFVEMIAWPFGCQVTVPTLPPRLTVQSLHFPVRQSFLAARSPRDRTIARSGILEGPVLIAQCRPETGFRSTTDAPGAGIAEVCDLFREVGGMLLAAQERAREGAVELRPGEGRWWTTAPRFGGAPNDGILDDLVRNAGGMPLPDSMLEEGGGKPSSPAEEVESARKRHKFEHPFIASLARRPSAMRKLSSAEKWKILQPGPSLWDKRMRYMQIGKAKESSYDDIYMISSINHHISLLHLRVHKRYLDVLTNGSSAIIPESDSDQPWHVLKLQRTRWYDILDGADRVEALKGVWALFHYQVRPTSASTTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMI1</accession>
    <name>A0A1Q5SMI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U4/U6 small nuclear ribonucleoprotein Prp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMI1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMI1"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001014">
        <property type="entry name" value="Pre-mRNA splicing factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001343">
        <property type="entry name" value="Pre-mRNA splicing factor, putative (AFU_orthologue AFUA_8G04590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000698">
        <property type="entry name" value="Putative pre-mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="521" mass="56829" checksum="805D6B5C98055826" modified="2017-04-12" version="1">MMHPSRQAYVEEAAEEMDTGIDLANIPVDTDYEIPASAAGIAPERASAIAAQFERKRRAAAMVVPTDDTRVRLRLRELGEPITLFGEGVVERRDRLRELLTDLADRRGEGDIEMEEAEEEEEAEQQEEFYTEGTDALLEARKAIARYSLPRAKARVARLKEESTIPLRTHVKHRKAVKEKLGGFDLYGSQIAGDRPVSICRFAPDGQTIAAGNWGGSIKLLTVPNLEEKANLKGHNDRVGGLAWFPGATLPESNVSPSSVNLISGGGEGNIKLWALDSDKPLATLSGHSGRVCRTEFHPSGRYAASASFDTTWRLWDVETTTELLLQEGHSREVYTISFNNDGSLLASGGLDSIGRIWDLRTGRTVMILEGHVREIFAMDWGVDGYRVLSGSGDGWVKCWDLRQVRNIGGIGAHKSVVSDLRWYKGAESASFLPTTDGQMEVDGAPAPTGDAGVQPKKSGTFFVSSGFDKNVNIFSADDWSLVKTLSGHSGNVLSTDVSGDAQWIASCGHDRTVKLWGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNB1</accession>
    <name>A0A1Q5SNB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNB1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="616" mass="68395" checksum="4350F2008B5161B5" modified="2017-04-12" version="1">MEPQESATPMAPPSRSLREQTQKRQRNSSPVTPSKRRRVQHLPSSVSQRTPASTQISCTSTPLSGPRTRAQLDRYYEDVKRDARRIIAVKNQLDVLLPEVDTDPQSTPAPTSGSMSMTTKNAVKLLEKILKDNQLIEDLEEVRKEVDPKVRGPRRSDTDGVVKHYRKKQQTTREKLRKDIRKARKRIGYNWDRLKAAQMVTEPEASTAEDTVSSSISYPVVSVAATEDGDDDSGAMADDSDSEPMLPTGNTVARSIMSPSFLPDHTVEEENRTSNDKDKAKTKRSGENGDADREASKINEPVEGKAAPESLPRSVQNSLLPCMALIHDYRTVRAPRRSIYTPDSVDDEDRPGQTGQKEISTHTATEESPHSDGGLADKMVEETTKPTNPREVETQVKPFSRRSVTPFFLSSVPLFNHELFSSSDDEISDSGEDEDSSEDDEDDEDGSDVEIKEEDEDLDVKLDMFGDGSEDDDEDEDEDESNDVGLKVEVEDQEEFKESSEDTRTEQDKEAEEATGDIESQKKGSDERLNVVQSGQGHPEDPKSSRPTTGLFERMNGIQTSGSFEAMMAGLRQAAAERERLAVLNGRIVDTDTSDSSDDESLPDWPPESDTKPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPR9</accession>
    <name>A0A1Q5SPR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000763">
        <property type="protein sequence ID" value="OKO89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPR9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="194" mass="20874" checksum="35C3A3F018B7ADC1" modified="2017-04-12" version="1">MNSAPPLPKPLTPQSHAEASAQNNHDKILREIQSLRDAISPSVPTGSPSYTDIARTPPLSHPSNIRTLSTSNTTPTTFTDTLYCTIDTSRIAENGNERISAGPIRAARCRAVTVDPKNTNRIRIACRDKAEHQLVKKVAEAKIGAGARVLRNELYPIKVDSVNKAAVLDENNEIRAGAAAAFSEENEATVAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRG5</accession>
    <name>A0A1Q5SRG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRG5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="79"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO90588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="542" mass="59872" checksum="9D2EEB95420C443C" modified="2017-04-12" version="1">MSFIDGVTTHPVPILSSLEQQKLPDKEHVIAAESENERTAEMPLEYAIGEGDSDVVLVDFEENDPENPLNWSSTHKWLIVFVVSWMGFVRLASFIFLSRRSVYPPSSTDRISVFSTMTIVPTTPQILQEFNSHSKVDQTLLVTIWELGEGIGPFFIAPLSERFGRLPVFHIGNFLALLCLIASALSVNIPMLIAFRFLTGCFLSILTLGPAIVGDLFQMERTGQAMALVMGTQMIADFTSPIAGAYIAQSLGWRWSIWLAAIILGFFSFLLLTVLRETYTVVILRRKAERLQEECADEKKYHSKHQALVDESTMLESAIKPMQILAQSPILILTTSYMAITYALVSLILATLTENMETTYPNVFSSGSVGLTFLSLAIGNTVALIFYGVTSDRYMIHQRETKGDAFKQESRLVHLIFAAIILPIGFLVYGWTLHFHVQYIVPLIGTCAAGFSMTLSAIPAETYVVDVYEIHGASAIAGGVIFRAIAGAFLPLIGPALYDSIGQGWGNTVLALIAAAFIPPLGLLMRYGDWFHSKERFGKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUE1</accession>
    <name>A0A1Q5SUE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUE1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012727923" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="87" mass="8892" checksum="C28B216CF940A3FC" modified="2017-04-12" version="1">MRIGISTLFLAGVTAGMASMESSSSKVASSSRLHERSYVKPLSCGGGNATATPSMQMQMNTFVTSTMVPGKSGCNASTNGENQVNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWA2</accession>
    <name>A0A1Q5SWA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWA2"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF23">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO92232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58512" checksum="CBD0D41A00A75DC2" modified="2017-04-12" version="1">MEDSTRRFSKVSASRAETGADTTSADRTLEDMGYKPELARNRSIWQVTFMCFILSSVPYGLSTTLYYPLVAGGPANIIWGWVVVSFLILCVAISLAEITSVYPTAGGVYYQTFVLSPLWCRRVASWICGWSYVAGNITITLAVNFGTALLFVGCLDVFEKSPGVGITDDFQAYQTFLIFLAITLLTHAISAFGNKWLPWLETFAIFWTIAGLIAIVVCLLAIAKEGRNNASWVFGNFEPQAGWPAGWSFFIGLLQAAYATSATGMIISLCEEVREPAIMVPKAMVGTIVINFVAGLLFLIPVCFVMPELSLLINASQPTPVIFKHAIGNSAGAFCLTIPLLVLGVICGVGCVTATSRCTWAFARDGGIPGSGWWRTVDKKLNIPLNAMALGMVIEIALGAIYFGSTAAYNAFSGVGVIFLTLSYACPVAVSLIFRRREDIKNGNFNFGIVGLIANVFALAWSLLAIPLFCMPTLKVVTKESMNYASVVFFGFVLIAAIWYGVWGYGNYRGPPTDAVDHDDASLSPSYPEGSEVGKDKPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWC6</accession>
    <name>A0A1Q5SWC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-hydroxybenzoate 6-hydroxylase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWC6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17697" checksum="7208039BEB318ECB" modified="2017-04-12" version="1">MPPFRIVIVGGGIAGFTAAIALRGPNRQITVLEQSRLNKEIGALISLQPNASRIVETTWGLKKELKAAQEIVDEGFRVYNTDGVLVNSVPLKTKTEFGADRLCFHRRDLHDQFKKAATSPDREGEPVTVRVASRVVDCSPLDGTVTLEGGEVVTGDLIIAADGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SY60</accession>
    <name>A0A1Q5SY60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc metalloproteinase nas-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000735">
        <property type="protein sequence ID" value="OKO92961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SY60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SY60"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012004801" evidence="1">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="371" mass="39595" checksum="D9E32E66707D49EA" modified="2017-04-12" version="1">MSLLVTICIALLIFSFSSAIVAAQTPSGSDPLYPLDKNVSVATIFDNSFGERNVSYFTTVERLAIIDGDVIYGTEAQLLSSEFRSFAVKQPWPGATVVYKYDTAGTAARVAAIVNTAIVRWQLVSPYLTFQQLSNNVTPMNGVLTISSNDCGGCNANVGFGALLPLQMNLQQPSTACNGSCGPNEATHELGHVLGLLHEHQRPDRERTVNYHCENLSPNCTGGATMPAGSDCCSGAPPGCCGNAHNFDIISGLGKSYEYQYDVNSVMHYVSQAFALPGTFTLTPVNTTVTLPTVNPSNPDVPDFERVCKIYEAQCPQAQSCLALGCPYKEKACTDFGSGYCSFHPYADGCGGSKAAKCVEKNEMCKENGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZF4</accession>
    <name>A0A1Q5SZF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="125" mass="13441" checksum="722BA1EB5AFD7146" modified="2017-04-12" version="1">MAATLDPPRLEVSGGGKIVEFESASITPPQSANGKKDAPEGVPSELSDLELDFKSAAGPGEPSIKREHSEELEVLEDIEPDHYYGGGKIPVFKPVSIPNLQTSLQLSWLNHSDKSSSQEEMLQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZI9</accession>
    <name>A0A1Q5SZI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZI9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="15281" checksum="268FB4C5E116E897" modified="2017-04-12" version="1">MDLQDRSVHAAIGHLSNPKQFVGEKPYEIFIDTQPGRPKTNMKFALCDGIPVKDVRFHGREQFSLDKNGFEFVNHSFDDQITINSIKQSGGDAALQSYLKPLQVFLQQHLKADKVILYDWRVASLVPSPLSYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZK1</accession>
    <name>A0A1Q5SZK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZK1"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="17931" checksum="6870E2407DA4D9F1" modified="2017-04-12" version="1">MAQRDPQFNQHVLVDTTPMPDHIPKVEEIGATSAFLSSAAYFIGDRCKAFNDDFMKCKDEANGRGEIECLKEGRKVTRCAASVIKDINTHCLDQFKAHADCLENNNHYLFECRKAEVSLNSCIFDKLGLKKTIPGAPENQVPVHLRPKQKYAQYPGPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T061</accession>
    <name>A0A1Q5T061_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T061"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T061"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="502" mass="53238" checksum="4FBB9C2BF8847FB5" modified="2017-04-12" version="1">MPAKGAKPTSDELLAQFDDLGIEQSGEKSTKPAAAAATDNNAKGEQEDVLAELEKQASQRPSSGPGTPRLSADKARSATKSPRLSATIERSSEDKTRLSAEVPRVSAKQEQQKQEPEPAAAQQQEQSQGGGWWGGFFAVAGAAVKQAEAAVKEIQNNEEAQRWAQQVKGNVGALRDFGGELRNMAIPTFTNLIHTLAPPISSHERLQIHVTHDLSGYPGIDPLVYAVFSRVMSQVEGGDLLVIQRGQESAPKRGLDVGGYMSSTGWNDGPWWRSVTPGTPRTVNAVRGAIEASKLARASAESYATEYFSTRGGIEEAAKQASEDLSESNPVRSSDIFLAIQAISQTVSAELFQAGASGERAETPGVVSAPEADEEIAFALYLHDPVHGIAFHTISQPVPAKWIEWLDASAPAAENPDSEDGDVPRAVVPEAIADIIEAGGVDPREWVAEWIEETLSLAAGVVAQRYVARRMGVGEGGVGKGKMRAEQASTVDSGAGEAARAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0X4</accession>
    <name>A0A1Q5T0X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0X4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0X4"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="401" mass="43110" checksum="ABD9C3B3FB327F1D" modified="2017-04-12" version="1">MSTWGEHFRVTTYGESHCRSVGCIVDGVPPGMQLTEEDIQPQMTRRRPGQSALTTPRNEKDRVEIQSGTEFGVTLGTPIGMIVRNEDQRPKDYGGSTMDLYPRPSHADFTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLKLSHNVEIVAFVSSVGNEYLFPPTPEHPTASTNPEYLKLLETIDRPTVDSFAPIRCPEARASERMTKVVEQFRDAQDSIGGTVTCVIRNVPVGLGEPCFDKLEAKLAHAMLSIPATKGFEIGSGFGGCEVPGSIHNDPFIVSDDGRLTTKTNNSGGIQGGISNGASIYFRVAFKPPATIGQAQNTAKYDLEEGTLEAKGRHDPCVVPRAVPIVEAMSALVIMDALMAQYAREAAKNRLPPLSTTLPTKPATAPNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T118</accession>
    <name>A0A1Q5T118_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sexual differentiation process protein isp7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T118"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T118"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="153" mass="17147" checksum="93FABFD6E4173BEA" modified="2017-04-12" version="1">MRYLHYPAQPKDEDERLNWGIGAHTDFGCVTLLLQDEVDGLQVLDAPSGQWLDVCDLIVYTSDIANKIYPQVKPVEGAYVVNLGDLFLRMANDKYKSNIHRVINKSGQEKYSIPFFFSGNPDYLLRVPSQLPGAGRACEISANYSPRHDDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2G9</accession>
    <name>A0A1Q5T2G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2G9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2G9"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="30558" checksum="9E7F26C7E6016A94" modified="2017-04-12" version="1">MFIQSLKRPRDEDLELLGANESRRLRPWHSIPEARSEYTADHDQSLRFRSSNLTPIDSSDDEREFRKQGAPVLGAGHPDKAKSAHGHRPPMLHLGAEGNMANNLRPVLASGDNLSPWLQPGSVQPSPIPHQLVNQFLTINGVPTTTPTHGYFPADASPVLATPQHLHVTGDMAGTNVISPGIPTPTSDNDDAVMGTPENIGDADADAEMGDYFPPSFTQTDSPAPSTGFSGVYQQAPPVVDNHHTSTCTAAPRRRSPLVMGYRADCNKCRCKVPGHYSHIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T362</accession>
    <name>A0A1Q5T362_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000716">
        <property type="protein sequence ID" value="OKO94689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T362"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="607" mass="68764" checksum="4C27B59BC1E7D2C5" modified="2017-04-12" version="1">MTTSHDTDVSEDDSLMAQANEQLERELLQKRFNLDRQSFQPFLEDHGDHLSIVVPDQNLADQPAERENRRALGFIQYEKKTGRITIANACMQLPINALAMGFSTKDVHGAHDHLVGRHGEGLKLAALVLSRNRYNVSIAASGCNWRFDMHADTASVSCTVAPSQKIKSIEWTDPALDMASLRYHVGRDVAVVIGATRAKSSRPVAPDAFLNWLRLTTMDIRGLTCPSGIISTPHGDLILDPQLRVQLYHNGITLANSTVGGAFLFAYNFAYSSTCRDRGRLASWRDAARQVQQIWEEALRKQVDTILPLLVDLLRKHARSADAEMIGPHLEPSAARQIWQYLLRESADKEFFYSERSNDQTANTIRDSLRKRPARLPDTLWHILRAHCPIRTVEEEQQELFKDAKPCIVPDTTFARAVDRALRACFALLKFTDHIQVVYVRGSAGKVDAYFDKGQGVLKLHRRWLDFACTHHQSFCRPWSPSNLADTNAPFFCGHVVEELLVRSIASMFKTHPTARPAEMRFMRQIGRRLRYLPHSIKLKPYPEGILVSWEDNETESFRTLSPSGPDYHVMLHDDNCANAETALLHDKADWVIQGMGTKIYTEYTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q9</accession>
    <name>A0A1Q5T4Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4Q9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF11">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="218"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="644" mass="74024" checksum="496F27E41AC6FB9B" modified="2017-04-12" version="1">MKSQLARLQRKVEELCQNRQLEYDEDTEAFQRPATELLSQTTSPLNNLPAMNTSGSTLDSRLISPEAPRSPQYYFAIFQTTDTFVAKATSPSSPSSIATSSQIRTLRKLGKGRDTPQPQRVSPRITKIVQLPESSILWSRVEAFLQEFGCFWPFLRGENVREKLSVAIGSTMRGSHPNQIIVTATNCKMIAILFNMLAYADLMDEVFATADISPGSQSYCQGLSLMESFGMLHDNDLETMIYYTIAASFFLAAEKLHTALQSASQAFHIARCLELNNQKRWPENTEAEIACRQSLWWTLYFLDKRITQKIGISYSVRENECGVREFDDDGTGESLRDHHEMLQSMVNYSHLWAYIWDGFFSPRASVKQIDFDEVELTDTKIMLAYRRLPDSLLWDYRKALEYMKGDNETQIRRRLLVFLVRFHKIQLKIAVVCIHRVLTLQPQRFTFLRLSIRHSHLRSEKHERQRRESCISLCKAMVDAVQSYTDSFGSHKPSGYFLTSALVESLYWIEIERRQETPVAEACHLDSIKETARRLLHDLSLSIGAASRAYQSLSDVLSNNVWEELLQDPENLPDFSELFIDEMHLPDNTSQVRMESGTPESTYSRLFSKSMPAWIAENGLNDLGDFDWEILMEPLPLTQTQNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4S4</accession>
    <name>A0A1Q5T4S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000705">
        <property type="protein sequence ID" value="OKO95228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4S4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO95228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="21758" checksum="54871A480E7A458F" modified="2017-04-12" version="1">MSIASTILDQTRYTRFSMDTSNINPAEELPEIQPTSGYHPADEPIIHMEQHPQIDVDLPSGPAIPDNTERPSLRDQPFAPAMEALARLEREDPKLAFQAARLVGLYRRLWESCMAKHMEEKKLAKANDGLRETQQQLMNEKSRMQSSHDDQLARLHFFDQALESSRLRLTEILKEWNRYSDGLESKPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T638</accession>
    <name>A0A1Q5T638_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T638"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="727" mass="79636" checksum="96E4A71C3C7766CE" modified="2017-04-12" version="1">MFPFPRKSSRSASKPATQLAALSAYGSSLMSESRYDSDAHFISTPRRDLIDSPAHRARRRMELSDLIERSQEQRESERWAIGQGDDIPEPPESVYGLRFIPTPPGTIRSQRSLYPKVHHAVSFEGHQNHTMNSARSLPDMHLASQRGNGSVAGPSPVNYIRGGNDQNCSTDSQSMDMSNQKHGATSPTSLSSQLPDLVVAKKRQRTDSGVFFMDGQPVHLEDMGISHRLASQSTSSTPVSCNPSIAELIHSNRYGIFMNTSHENMPKAQRSTTSITSGHNLQAPIYHHQVGSSYYSEHPSSLLGNASPLRSPSLALNSEQYVVTVHGSKYNVAAEEANLQHARALASPAIGSKFREHCDSVISLNPHGKVESKEAPGVEAPRKVSVGWMSGGRRVGYGYSPVPDEEAAQYEQHGHGHPNPQQAPGQKAEAAMSDANLPGGHIRHNQVQKSDLVHAAGPSTPEPQSKTVNHPANTPEVNPTSLLSGGDSNQTNNEFPEPPYLRAIMEGRHSREQDCGPVVSEKRSTRSLHAAKMPPMTQSEHSHVPQSTNNMSQQSDTALQHCSRLSQSLNSNPQKPKNKRGHRTGIPDSVRQEKGQHVPSSEHTAVDIDPGYLGIEHDSNAEDAARLLRPSNPRNANWVRRLSKHQVSKRQSNAHGQEVSQLSPGLYRNFGSGSLERADSTKSIGTNVEELASMYQECLEMPGSFEGSRWASRTSRMLWDLVTTDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6J7</accession>
    <name>A0A1Q5T6J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6J7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6J7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="508" mass="56431" checksum="0D8FA2C0BD59C525" modified="2017-04-12" version="1">MSIKTVRLEKEYEKAIAESARLLDTERDRARRMEYLLLQIDRDALQAKFDQANDRIVVLTQAESEARSRLDEAFLEIDSLDHHIQASSNQIQRLTDELSTLNNTSTSNNTLLTEKMHLSRELTNAKSKLERLQTQNTSHQSIVAEKQALERQLNTLELQLENEKNSHERTRVKSSEQTTQITKLSSKIEELQNELAKEQRANQQREQDRQSNAGWEKERSVLEGKIETLRKQLRSTKDKLHEAQHDLQQRSNSRGIEADGTEAGSRRVPLQRPGPSADSLGGGMTIATPGAVRVQEKPKRPSALPGDKSAFSITPFLNRTGAAPRDSPMSSDVDEDEIERARNRTTAAARKPSAARDSNDVISSPSEQAGPAQPPPKTKSTTAKPQARAGKSAASKATREPKQQMSRPASKVSLEEPDDLLHDGPAEAGPTKTKRRKLGAQRERNLFEDEDDDDMLDLRKPRKLTLGAGRQSVLAAPLSTASTGDLLGRGGGFGAARAFSPLKRDRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y1</accession>
    <name>A0A1Q5T6Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="347" mass="37669" checksum="AB89847276733B97" modified="2017-04-12" version="1">MAPSEEADNDVSQAPASKRRRVAVACDACRTRKSRCDGVRPRCSLCRDLGFECVYTPPPTATNVIVQKDYLRGLEERVKRLEEGMVGVRGDIDGLVGRVDGAQGQSVATGDGSSSTSLQTARRVEDDGQRLAVVPVPNLIGTEDSVDAMGAVTFADEEDSGFFGLTNPKSYTDRAMADNCWAGPSSNIAFLRHLSRAVVQQGYLLSPGAAEGGFVNASRPPSPPRQTPHDQRSKVNIFALPPQSETLALIQRYFSETGLLFPYIYPPTFLETYHQMTRENFTKVRRTWLGLLNMVLAMATITAMPGGARADARISESDVFYQRGLGLCGSEILRGTTLEVGKSGPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T841</accession>
    <name>A0A1Q5T841_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T841"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T841"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000391">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16058" checksum="12485EDD50E0582B" modified="2017-04-12" version="1">MPLFGREKGRSPRSRRSDDEFVVFLQGIPAHCRWQELKDLVRQTALHIRQAVVYDDSHGFPTGLGQIIVKNEDEAWRTYHRLSTNGWEGQSLVVTLARTSSPTKPVAGPTRSPPAMIHGYMSGHSTPPRSQGNMTMPPSPVSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8G4</accession>
    <name>A0A1Q5T8G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8G4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8G4"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO96521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="188" mass="20789" checksum="2D605DE4E68C9B2E" modified="2017-04-12" version="1">MSSVKSASAPIYFGSFLVTPQVFHQTPLSFALVNLKPILPGHVLVSPRRVVPRVADLTPAETSDLFLTVRRVGRMVERLYGATSLNIAVQDGVHAGQSVPHVHAHIIPRKPADLDPIDAVYDMLDGDEGDLGRAQREAETGCAAESERAKNRPRFPVVDNEERKPRTAEEMKAEAEMLRREMEKEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V3</accession>
    <name>A0A1Q5T8V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8V3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="91663" checksum="A27E62C4D09D60E3" modified="2017-04-12" version="1">MSDPPRPSPSFGERRGHQLAPLQTNFSRPTANSSKTTSTRLQRPRPTDYPSTNGSENPVPLQSPVKRQSSKSSLRSLFARDKSQRAAAAPDAKLAEIEENQPPTNPEPTETTQTVTVADAPLSPSVTSPRTVVSTPTLTSPTTPRARTTLKTPRPRPAATDSKPVSQDQYGWKPPPLFQAYPQSYKHECLSAPAMSADAILRLHATTGKSIAEVAPDETADAARKKREQKERKHLRTLSGTINKVEWTTKIYVLATAGFILQYAGEGKNDRLPECMLQLGPQSVAFASDAIPGKHWVLQVSHKAAAENGPGASEPAKSGRFSRFGFHRSNAKRMASSFLLVFDSPDSMISWLTAVRAEIEVRGGPKFTAEKHSDDDQMPQLRSKSSARNIVKKDPHRISSLFLQPQGIRSPDEEDGSSVGGMTWQSRRSSYVSMNRQSIIDSRSGSVSTGWTEATGPSNGSDIQSSSFTSVNPPNSPPQDSSRPSDEARSRDVDSTNTRSPPTSSHGNAKRQSLYMSAKLQDFPAVPRSEAIPYSQSPPPNIPDSLVRSASPPAPNFSVPSFSKKFVARPGPPPLASPPAPLAGVLRRGESIGDFSISSISSPPQSPTYSVASSKQTDSPEPILITREPNGRRILRPSNSEDALSRTVRSSQNMVNLSRLPRSTPSETSPPPSRPLSMVGRSGLGIQMNGEPPAQSLPPGEPLPVLRPRMSNMNMDQNPQNISRRKSMPGLTIGPPAAPPPNCPLPKIPSPIAAQAAPVWSTSPPPAQPPIWSTSPPPAQPAPSWSASPPPGQPSPVWSTSPPADRFYQSQQIRDHIQQDRRKSGLPPINPAPANGKLSKQAARQSRMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9F8</accession>
    <name>A0A1Q5T9F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9F8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9F8"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="466" mass="52644" checksum="7F8DEFE8D7F2538F" modified="2017-04-12" version="1">MASTPYLERYRQLGTLDQQKNQLIEDLLQRVTDLETSFAQEKLDHERETRFNRDIQLHEMELMQQISQIKTIMDREPFVVVLLDGEGIIFKDEFLQAGEEGGRTAADQLYAAIHSYLKSNLPSVTTPKIMMKIYLNARGFGEQCTRNGIFTDPGAIHDFIRGFNETMSCSEIVDVGSGKNSAHNKIQETFQVFLYNCHCHQIFVGCPSNSEYALFLEHVSKDNDLTGRISLVEGVAFEKELDAVKGSYRIAKFPDVFRSAKMANLWAAAPWKSTLPTRSVLTPSPSRQFSNLSNPPALSRTSTNTSASGVALSVATPNQIDTTPDFQEVARPKPAVSTAPKTVERNKYGQRVDRLDFKSIPRDDLNRLKKLKLCNYHFLLGECPNDPNCYHDHKRKLTKQELHILTAIARMTPCRFGLECDDPECIYGHRCPQSEPGKKTCFRGDSCRFEPVAHGIDTNIVKVTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAJ2</accession>
    <name>A0A1Q5TAJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAJ2"/>
    <dbReference type="OrthoDB" id="4370002at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012614999" evidence="2">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="30617" checksum="AC8204E1FE3CFADA" modified="2017-04-12" version="1">MVNALTILALASPAFAGVMQARGADYIHPSSAVGEWVPVEGGHSSWSTPCTTSTTATSTHSTHSTHSTSTKPTTTPCTTSTTTHSTSTKHTTTPCTTSTTAHSTSTKPSHTPVKPGPTTKTITIVTTTCPVTSSTVTEGTSTFTIPVTRTSTITLTKTTVCTLCEEKPVTFLNSTVPVTKPTSVPVVPPAESSVPAKQPSAQPSAQPSAQPSAQPPAQPSAQPSANPASPAESAKPAESAKPAESAKPAESAKPAESAKPAESAAQPPTSQPQASSSSVPFTGAASNVKPAAGLLAGIVGMMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAV4</accession>
    <name>A0A1Q5TAV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Semialdehyde dehydrogenase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAV4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAV4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase dimerisation" evidence="6">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="28791" checksum="78B95EAE56711FC8" modified="2017-04-12" version="1">MAFIKAEIPVFSNAKNYRKDPIVPLVVPTVNPSHMDLIPHQRKHFGLKKGFLVCNSNCAVIGIVIPFAAIQAKFGPVEEVEVFTEQAISGAGYPGVPSLDIVDNVIPYISGEEDKLENEAQKILGSLNADATAFNEQAGLRIGATCTRVGVTDGHMAFVSLRFKNRPAPKAEEVVQAMREYQSEAQKLGAPSAPELAIKVFDEPDRPQPRLDRDISKGYTVSVGRVRDGAEGGYFDIRFAALSHNTVIGAAGSSILNAEVAVIKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC45</accession>
    <name>A0A1Q5TC45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC45"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC45"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="505" mass="55304" checksum="D684746B59F078F3" modified="2017-04-12" version="1">MSRQSQDIEVADVDKSYVDNIEHVANANKPNPRKEAPAYVAGLSPEERAAAEKALVRKIDIRLLPMIIIMYILNYLDRNNIAAARLAGLEKDLGLVGNQYLTCVSILFVGYLLMQIPSNLLLNKFGKPAIYLPTAMVLWGIISTATAAAHNFAGLVVIRFFLGFVEAAYFPGCLYFLSAWYTRKELGFRTAALYSGSLLSGAFSGLIAAGITSGMDNKLGLRAWRWLFIIEGAITIVVAVIAVFVLPNFPRTTSWLTEEEKALAAWRLEEDIGEDDWVDSEDQSFLHGAKLAFTDIKTYILMLMILCIVSSASVTNFFPTVVKTLKYPNIETLLLTAPPYCLAVVCAFANAWHADRTGERYFHVTIPLYVSVAAFIIAAATTSTAPRYLSMMLMPASFYSGYVVALGWISNTLPRPASKRAAALAAINCVSNASSIYASYMYPSSDGPRFVPAMSVNCATAFIAILAATALRFTLVRLNKKLDRGEHVEGSVPGHASSRGFRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCZ7</accession>
    <name>A0A1Q5TCZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCZ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6559" checksum="B7337B0F8F2E1954" modified="2017-04-12" version="1">MSSTPPPEHRGQQRPHASEPEEEAAPSLPPQYRHPELDFLHSQLKEIVPPAPNQMDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDH7</accession>
    <name>A0A1Q5TDH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_9373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDH7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDH7"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="237"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO98275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="330" mass="35536" checksum="F6961EBEF465F888" modified="2017-04-12" version="1">MASNSIKESAHNAAVSAQQAVENPAQTSSTILQHPYMRAALPFVNGGLAGMTATIVIQPVDMVKVRLQLAGEGARTGPKPSALGITKEIIASGKALDLYTGLSAGLLRQAVYTTARLGFFDTFIKKLNVRAEEQKRKVTFAERAAAGLSAGGIAAMIGNPADLALVRMQSDGLKPPEARANYRSVFDALVRIPKQEGLAALWAGALPTVIRAMALNMGQLTFFAESKAQLKQHTSLSAQNQTFAASAIAGFFASFLSLPFDFVKTRLQKQQKDLATGKVPYKGVLDCARKVVQEEGWLRFYRGFGTYYVRIAPHAMVTLIVADYLNLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE76</accession>
    <name>A0A1Q5TE76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9196</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE76"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="183"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="372" mass="41207" checksum="047A2697BD85EB3E" modified="2017-04-12" version="1">MAPTGILARIKSLYTKHQGMPLLSSDLPTQQPQRPDEDHKVQTCQLTARLDEPSLSVQTVALFSVALTLLYVLPFYLSPSTRPSPSLSRDAPSVIRARIRAVTGSCLVCSLVVLWLVVDKGGSSLSAALSLLGWWPIDLGDILRSLLLTAILFVGPLYERGIVEGEWRSWFSRAKWSESLGGWIGWRNYIAGPITEEVMFRSAIVPLHILAHISPARIIFLSPLYFGIAHIHHFYEFRLTHPDTPALAALLRSLFQFSYTTVFGWYATFVYLRTGSLPAVILVHSLCNWCGLPRFWGRVEAGEPLGPPVRGKDDEDGKGRGVSVGNGELSIVWTVVYYALLVVGAMGFAWALWPLTASYNALIDFKVRKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEA2</accession>
    <name>A0A1Q5TEA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEA2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEA2"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="378" mass="43289" checksum="47CF6D955181550D" modified="2017-04-12" version="1">MNEAAFDIQPVNRFGGSNTTIRRPKEIACFSYDQQRRFSLGDSSIAYYYPPSLPADLNIGFDTFQKLNDAADEHLDALLDTIVAMEKETGKKCETDIVTWRGMMTKILTAPFDMMNGFEMNATCYQGTIFIEENNTYKNRQKELQKNQRMPPGMASQELMMYWGYKFEVLSVLHKTWDECTRAEIEGRQNEVVNNSAQYCSVVKTGMGNVRMVLGGEVDAVWDCKPDRKDDPINWVELKTSAEIRSDRDMIKYERKLLKFWAQSFLLGVPKIIVGFRDQQGIVHRLEELETASIPGKVKKVGRGTWDGNICINFAAEFMEWLKQVIQGDGVWRIRKLEKSHVIQVYKVEESGHGDILSSAFKTWRESLVGNDCTMDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEY3</accession>
    <name>A0A1Q5TEY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol uptake control protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEY3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44301" checksum="69CDFC5748A7FCD9" modified="2017-04-12" version="1">MLSRYPPRPRLTRLDTKPRSTSSISSVSSADMSDVSVSLPPPTAVVAAATMTDLVSTLDQPAPKEEGSPLTAATRFSPKGEEPLHLLDLEFMMHWCTTTYRSMARDHAAETLWQMAIPQLSLRFPALRHGLLALSALQLARDTPSSTRKWRYMVSAREHQTHALAGVQFDSAEDLTTAQCNAAFALCCVLVVFPFAYCLIDDSDVEDEDERPEVLDEFLEVFELTRWLVGAMMLMMDRVASGELYPLVRPEPTRPTMPDMSQLVISALRRRNVVEAERDPSHETDVYEQALEHLRYSLEQLMGGGEPKDFAFCWAFRIPVRFQDLVREREPFALVVLAHYAVVLHHMHQAWWMGNWGTRILKEIADYLDPEWRELIRWPIDATGCSVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF84</accession>
    <name>A0A1Q5TF84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8807</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF84"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF84"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="46125" checksum="561DCDACBE4A1607" modified="2017-04-12" version="1">MSSKKEPQSQVPPQSKGSWSSFLKSIASFNGDLSSLTAPPFILSTTSLTEYSAYWAEHPSVFVAPAKEADPEKRALLVLKWFLTTLHQQYCSRSEKLGSEKKPLNPFLGELFIGKWLAGADAELGETTLISEQVSHHPPVTAYAIQNEKHGVELQGYNAQKASFSSTIQVKQIGHAQYTITPPGSSEKEKYVITLPSLHIESLIYGTPFVELEKSTKIASSSGYIAKIDYSGKGWLSGKKNTFTASLYKASEGEKKPLYTVDGQWSDTFTIKDARTKEIVDRWVVKDNATTPLTLAPLEQQDLYESRRAWADVADNIKKGDMDAVSGYKSRIENAQRELRRVEKSEGRDWERRFFNCVEEKDDDPLFQQAASSIDYAGCLEADKTGGIWRFDTTRAAGAQPPYHKVGGEGLGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFA8</accession>
    <name>A0A1Q5TFA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0592 membrane protein C7D4.03c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFA8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125034" checksum="614D8E49B35C7CD9" modified="2017-04-12" version="1">MSSPALKITTTTSSSYPADDNNVLLSRAASYTDLPSQSPESGPPSLRRTFSDYAVPTLSQSPTKEVVAAGKDILRRTSLRSKKKPEKSPAAVAHFTLSSSEDLKDLDTQNVTATKMPETRAPEPVARPLKSRSMSGRIVNLARKPWGSASRSPSPAAKRTKQRPEEESPTRSSTRKTEQADMDGAQPSRRRTVLYKRPRRPMVAVVTKGNSDSPDSPNSPSNSLRNKTSFEKFTASLSVTTPVLPPMPKGAAATVASFTNNNSSTIEHSRKKDELWGIFRGLEADFQKFQSKSSSLKANVIRTSLLPFLGRHHLHGSCKNLRPEDLDRRVNILNKWWIGMLEMLNGKNNQSISGTDRPVFLEAVVGIMTRPEWRIPFPTAQQNDAPTDSLKYASTSVSETSDGSGSSGSDFLVESIHHNIRNVFVQNLLSQMAFVVERMSMRHAPASLVAFCGKACSYAFFFCPGVADIMVRLWNTPPTAFRRILAETSQSRTGNMRAFTQELALSFPPALRSLAFHSHAPLLRYMRHKPEPPLNTTNIPWSGPWIARWCGRDTDLFFVFVKYIHILYAEYMPPETEKANRILAPGLLLVHAQLLIAIEDTIYKQSLHQPENAHAAAAITFDDLIESPDASASPHSLAGGRNSHRSMAENRLIILLRDLLSESSSEPNRARLLYAETFCGLLKVAAQRISLFDHNACFLLCDFLEEVIPIVTRYAQSIETELFDWSFWLEVCRQMMQSHNSLTEVRVFSFIYSIWGTWAVTEERKASLCLNFFLHEPVFYHYFNHWSPMVRAYYHRVLCWRIGRFSGDPSPLDSLLRVWEFYIGFQSKAEQGLTAPLSSAPCTPAPGRRIIIIRCDTQLSPVNLFVSFDRVVPPVPPEKVTSHRRSSSADSTGSDGQPPKRRWGLLRSMFGGSAKSDSAGGSSSDEDNSATDLTVTPDSRCMDEHEKTPNQSSDELVRPKTPHQPYFFKFSLEWMDRPNWPTKNKRLFTPCLPVASQLHVQHCRSRSPSKSTEFDTASENLSTSDEKSTQGTNQTNSSQLAADSQARTPTTKNSPLPELPSRPKQDYVVTSKYAGRALAEWAHIVSECDSFFARRRDEGVPSDRMVETPSLGVESFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG14</accession>
    <name>A0A1Q5TG14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylacetamide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="95"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="190" mass="21249" checksum="734011ABD3B189F0" modified="2017-04-12" version="1">MADFSHYGYLAEEWTSYVRQHAPLPLPRYDSPEIMAASRRITNAARLNASRSMMEERSTENIQTQTVATPTNDFQEISARIYRPRESHPSSKAVLVYFHGGGFLTGTLGSEDSTCFQLAQACGIVVVSVNYRHTPEWTCPVPFQDVWDARNWILQNQGQHLLPSKIDLYVGGISSGACLAASVVIRERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGI3</accession>
    <name>A0A1Q5TGI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_8706</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="15">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGI3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF423">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="437"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="670"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO99319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="732" mass="79828" checksum="BC45CA67FB07F3D8" modified="2017-04-12" version="1">MVKENNLVRVLRACETMGNATVICSDKTGTLTQNKMTVVAGSWGSVLNFTQSSETRDGETSMTTAEAFKQCSAPVRDLIVKSVALNSTAFEEDKDGQRGFVGSKTEVALLQMAQDHLGMDLVAERGSADIVQLIPFDSARKCMGVVYRHAGVGYRLLVKGASELMVDACSMQITEIDMSKDKVNTEPLSETGQQKILDTIDRYAQGSLRTIGIVYKDFDSWPPKGGKKHDDESSAEFGDFFKGMTWVGVVGIQDPLRPEVPPAIEKCRMAGVQVKMVTGDNVATATAIASSCGIKTEDGLVMEGPKFRQLSDEEMDEVVPRLQVLARSSPEDKRILVERLKLLGETVAVTGDGTNDGPALRTADVGFSMGIAGTEVAKEASSIILLDDNFKSIVTAISWGRAVNDAVAKFLQFQITVNITAVVLTFVSSVYSSSNSSVLNAVQLLWVNLIMDTFAALALATDAPTEKILDRKPVPKSASLFTLTMWKMILGQAIYQLAVTFMLYFAGDKILGAHLDDTDLDHRSKQLSTVVFNTFVWMQIFNEFNNRRLDNKFNIFEGMLRNYWFLSINAVMVGGQVMIVYVGGQAFGVTRLSGILWAVCIICALGCLPWAVVLRTIPDRHFGVVFNAVVGGMNAVLRPVVKGFNALARGLKALFQPLVRFTRRLFSRRENKTGDSDESSIEIPSTTQTVDEEAPASTLTPAPPKVIREDDPERPRTPPAIAVPPILVTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGR3</accession>
    <name>A0A1Q5TGR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000659">
        <property type="protein sequence ID" value="OKO99414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGR3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="10853" checksum="A94C0A557A297A9A" modified="2017-04-12" version="1">MSLVHRLVIHSFNVSPLPFINAASSPSSPSSPSSPFSPSTPSSPSTPSSPSTPSSPSTPSSPSTPSTPSTPSTPSSPSSPSTPSYRLTNHTVNTVLTIHTVHTSTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THF6</accession>
    <name>A0A1Q5THF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase beta chain-like PALP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THF6"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="55"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="369" mass="39613" checksum="4FB6A601665A0FCF" modified="2017-04-12" version="1">MTSPAEKAQSLTPSAIHAAYALIQPYIHRTPLLTCKTLDTIASTPQTPEALVGTPFEGQTPACPKFHFFFKCENLQRIGAFKARGAFHALLRLIEERGEEEVKRRGVITHSSGNHAQALALAASTLNVPAYIVMPRISTPSKIAGTRSHGAEVIFSGSTSVEREAVVAEIQAKTNAILVPPYDDFNIICGQGTTALELEAQYAEQQAGSKTLNAVITPIGGGGLNAGVATYFSDKQTKVFGAEPSFEGADDCRRGLLAGKRVEAVSTLTIGDGLRTPVGLLNWEVISNKEKVEGVYAVTEEQIKAAMRLVLERMKVFVEPSAVVGLAVCLFDEDFRRLVEREGGDEGWDMAIVFSGGNTTVEAISKLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI44</accession>
    <name>A0A1Q5TI44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI44"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11970" checksum="0DE2E56753C90EBD" modified="2017-04-12" version="1">MDSTSHAQPLADRPTNTHLANANSGDKSDLKGDISSMDYHRQALQGKLESGEKQPSAYVSPSDDIMSPCTKKLSDIKGKRFKNAGKPQSLFAKLGKKSYEQSSSAGQQAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIF1</accession>
    <name>A0A1Q5TIF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIF1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIF1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="233" mass="26433" checksum="E28FEBABE395BA70" modified="2017-04-12" version="1">MGWWYGRDTVSRYKGIEDSLSFLARYIHGRPIHGIIGFSQGACISGMICSLLESRNDPEKAAAIRLQNLPLDEYLRLPGQEPLRFFIGIGGYRGTLQYYGSLYSSLINTPSCHALASMDFIVERFQTMNLTECFSSSEIVQFYGCHFVPRDRGTVESLARFALRNAREGSPSSLFPSVARTWSQSDSDETQSSTWGPDQSLRIHLVWRELRKPRVVRGRVIRFNSRRSASTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIK7</accession>
    <name>A0A1Q5TIK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46858" checksum="2A0C75F56FDDCA83" modified="2017-04-12" version="1" fragment="single">KFHYYRTNQVVKSRLAILQVPDAISSAFNLIARIAVEPIVAHYIQEADFVKDGELSKGKPHDFVTRGSHDGAMMRLLASSPYLKQAGLDWKEYWAVMQEDLDAGRYSQYAAAFVLSLLPNIKVLGLPKWWMPQAASDKLIETVICKARKNPTCSSSTGLVQLTNLIGHGCADGRFNLDWESCFLTLPHIRYFGATWCKGGSERRRSSAQKYEALELVCFVNASIDSIEIASFLQNTPRLTTFKFWHSAGNIDPTQGWGLCQFVMAIGHHVGDHLVELSILLDDDPHTTISPGRASLGGFKRLETFQLPLEIVSCNLIATATATASDVFELLTRDLIPASVTHLSLVSCGTDKEAKALAAIFHDFPAVKAQTPSLREIRLTLPAEATGLYGDHFDKVSAEIEMAGVVFREEQRIQAVAWDDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJS9</accession>
    <name>A0A1Q5TJS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJS9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="15297" checksum="A04CF5CE7DA244C1" modified="2017-04-12" version="1">MTAKLQEVTQLLGTLKKDLQEKHLTSARESQEQSFDRYVILTFEFHYPEKVQTLLQLRQHGTNPVDAGPIYCNDGIGLLARYGVEGETADVRRAALRCVANALLLDSSMRQVFADTGYGGKLAERLKVPIPFSITTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKI0</accession>
    <name>A0A1Q5TKI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKI0"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="89"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="487" mass="52436" checksum="E956B7C55A42965C" modified="2017-04-12" version="1">MPYNTRRKSLSLPSLGIHLPNSSRRSPSISKQAATDDVPPTKKVKRSHTSLSPEPSTDRRESVVRAGRHGAFEHTPPPSPMDGGVAPKIDTQGINDDIVVAVIEQLEKTGNRPHLVKQLAAVLVNLNTTVANSANPAALLSSRLAAYMKRPWTALSPCPMAKELILIHPRKVYYYLTTFPRQPIPDPSDDPTLGVDGKHITPSVSSLDQDDEDLIARQRSPSPEVDLSSPDFEEGQDVDLENPAGRGTSSDQFPDPSSHTRLMHSHRAASPPLEGDEKEFTQTASAVRERASEEKANQTARSLSVLSEGLSSIDEEMSIIDSPVNGGSLSPAGDRMSEQEFSDYFTHMNPSVQIGADLDEAAAAALFGTSPSPSLTSVASSVSSGTSADAELEAEERAGMLPSAPQISLPEVAPVSTLKRSLDMLNSGLPDVDLKMSDLTESHEKLSLGPRSLAGMDASEPIFDSWRELQNPETVEVDELDEMFGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TLC7</accession>
    <name>A0A1Q5TLC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 4E type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP01040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TLC7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TLC7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="316" mass="34127" checksum="9AF77D207A50C08F" modified="2017-04-12" version="1">MSGTDGKDGARVDLPRPSKRFGPDSSHGRSNPFNAISPLSAGVSSPSTNASSAFGLGSGAFASFGAPKTPGGSSEVKAPGEKRDISAEQEDLLRSKSHANGPAGLGEHALKSTWIVWYRPPTPKYSDYEKSTVPLASISSVESFWAVYSHLKRPSLLPTVSDYHIFKKGIRPVWEDEANKRGGKWIVRLKKGVADRYWEDLLLALVGDQFAEAGDEVCGAVLSVRGGEDVLSVWTKNDGGRNIKIRETIKRMLAFPADTNIMWKSHDDSIAQRSAIDQARHEKSQTSGTNPTGHQGSERRRTGHDDSDKGKGTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM16</accession>
    <name>A0A1Q5TM16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM16"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP01276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="43494" checksum="BB0E96CA7D699B54" modified="2017-04-12" version="1">MPPKKAQVQEKVLLGRPGNNLKSGIVGLANVGKSTLFQSITKSSLGNPANFPYATIDPEEARVIVPDERFDWLCQHYKPKSQVPANLTVYDIAGLTRGASTGAGLGNSFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVDPVRDLTIISEELRIKDIEFVEKALEALSKQTRRGGQSLEMKKLKEEEATTAKVLEWLKDGKDIREGEWGPKEVEVINPLFLLTAKPVVYLVNLSEKDFIRKKNKYLPKLFEWVKEKSPNSPILPISAQFEERLTQMGDDAAAEEECKKLGTASGLPKVITTMRQALNLASFFTTGTDEVRQWTIRKGIKAPSAAGVIHTDFEKTFIQAVVYNYSTLKELGDEAAVKAAGKVMTKGKDYVVEDGDIMLIKAGAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQK7</accession>
    <name>A0A1Q5TQK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_7049</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQK7"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="43"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP02516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="58912" checksum="CAC8AAC42487CFA0" modified="2017-04-12" version="1">MATVSDPEKNPSESKTQGDIFDGSATPFVNADKLARRLSARQVQMIAIGGTIGTGLFLGTGSSLAKGGPASTLIAYAICGGIVFITMLCLGEMAAFIPVAGSFCTYAGRFVDDALGFALTWNYWFNDAVSTASDIIALQLLLEFWTENFPGWAISLIFLVVVIALNVLSVRVYGEVEYWLSLLKVITIVIFIILGIAVNCGGNVNHEYIGGKYWHTGDAPFVGGIGGFASVFVTASFAYGGTESIAITAGETKDPAKTMPKVVRNVFWRILLFYLLSILIVGLNVPYNYPGLSDRNTKTSPFTIVFQQAGSTVAGSFINAVIMTSVISAANHALFAGSRLLYTLAVDGYAPRFFGQLNRFQVPWIAVLATSVISGLCFGASYIGAGQLWTWLQNIVGVSNQLSWICICLASLRFRSAIKAQGIEHLLPFKNWTYPYGPIFAVGLNVVLVLVQGWKCFSPHFKGVDFVSYYIEIAVMVVMFLGWKLLKRTRFVRTSEMDLRTDRYDGGADDGHYREEIAVEEKRKGFVGKLQRAGQWLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TXQ4</accession>
    <name>A0A1Q5TXQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000607">
        <property type="protein sequence ID" value="OKP05002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TXQ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TXQ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP05002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="596" mass="65614" checksum="C8215D69DBFF006E" modified="2017-04-12" version="1">MFWIHGGAFTGGSGSDPTFDGGNLASRGDVVVVTINYRLGTLGFLALNDGITNGNYGMADQITALDWVRRNIQDFGGDPNQITIFGQSAGAGSVRALLASPKAQGKFAGAIMQSNLGGLAYGTTYSKYYTIEQEMQVAGNAILSETNCTDASSQLDCLRAVPATTISSLRATTRYLVVDGEYLTSSELNLKDPGSTARVPLMLGTTRDDGATTIGYPKEGETFQQFLNRSGLPPIVAGSQVFPIPSGSNQTLNIFNTTVRVATDGMFRCIDQATAYAGFANKVFPEVFFYEFNRTYPVPEWSPNPPLCQAPVSSDYPNGDPRREYFKCHSGELYYVFGNVVRQGLPLRDEFDLPFQQFVLDSWASFARSFNPTPDTKYTKARGYVNTTRQVEVTGPWTPFKHDSYQLRFLQWPSAMVDLDETEQWFNSQTPSIPQFLRTIIQRPELAALVKVAVHEGQDFDGSIRYYKHRSLKLAVTGDDLKPLVEYIRTTNVSNCDESIQELRSVSMDASVMLQLSQLSSPKSIYLGETSLANAALSDVSFGPPSVRGAIAFIPFNIYTTSQCCILVLVLANEVQNATSHAVHQKRQRGKKENMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D6</accession>
    <name>A0A1Q5U0D6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_6643</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U0D6"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000018">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012004814" description="Lysophospholipase NTE1" evidence="18">
        <location>
            <begin position="17"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="704"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="19">
        <location>
            <begin position="861"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="20">
        <location>
            <begin position="1240"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="305"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="355"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1244"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1271"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1391"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP05923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1543" mass="170141" checksum="1F2A71618E1BD7A7" modified="2017-04-12" version="1">MATGLAPSLALTLTSAASSSSSTGLNSAAAALAAASASSSGLSLAAAAIPTASTALSAVPTHHPPPFLPPTPSTMAGWIAWVFTFIFQVIPRGLYWTIAFTTITLPTWLFTLFSMSLTFTMNFTTLMLIILVLVSTVSWFIRYRFLNMYSRLPPEPQRKEAQIDLFPDVQEGDTKPGLSNYLDEFFSAIKVFGYLERPVFHELTRTMQTRKLIAGETLMLEEEKGFCMVVDGLVQIFVKSTRQGNKMGSSEDLHLDDDATSDEEDNQMHGRQGYQLLTEVKNGASMSSLFSILSLFTEDIQLRNSHSSSSSTSSAGPDPANFHAESLPVSPSVGVIGSPQSTIRDYGDPLRTMNGHVDGLPAVPPLHLGESHGLPNHTPEPNLNRQNKKRRKSVHPDIVARATVDTTIAIIPASAFRRLTRVYPRATAHIVQVILTRLQRVTFATAHSYLGLTTDVLGIERQISKFTTWDLPNDLRGSALDRLKDKFMRERDRLGPEEVCKGIALHNPSVGRRRRSSSSLRKEAVLQARMMGNSRPVPLTPHRQPTAFMDRDMMGVSPGDLLSTIQLSRFGPRGDHISPQLQSPLTEKERPLFQAARKDLRPSPFQRKDSIDEDTLFRESILDCMMKAIGLTESTSDALRNSSHNSGEASPKLLSYDSRRQKAVFSNAFGFIDPYEGSGDGETESMMSMSVTSAGGTSPVVNLREDLRHDIEVVYFPQGSVLVEQGERHPGLYYVIDGFLDVGIPVNERGDDLVGSSRPSDGPISQAQEELFPNLTRTITASSRVSASNGSGDSRRKSHSRKSLYLIKPGGIQGYVGALASYRSYTDVVAKTDVYVGFLPRASLERIADRYPIALLTLAKRLTSLLPRLLLHIDFALEWVQVNAGQVIYHQGDESDAIYLVLNGRLRSVLEGSKGKMTVIGEYGQGESVGELEVMTESTRPATLHAIRDTELAKFPRSLFNSLAQEHPGITIQVSKLIAQRMRDLVEHPLSDKGIEQGSVGGVQTATSTVNLRTVAILPVTAGVPVVEFGHRLLNALHQIGVTRGVTSLNQAAILNHLGRHAFSKMGKLKLSQYLADLEEKYGLVLYIADTNVNSPWTQTCIAQADSILLVGLAESSPRIGEYERFLLGMKTTARKELVLLHAERYCSPGLTRRWLKNRVWINGGHHHIQMAFRLTTEPSHPQTRKFGTVLKQRVQILQAEIQKYTSRRIQQTPLYSPQTPFKGDFHRLARRLCGKSVGLVLGGGGARGIAQVGVIKALEEAGIPIDIIGGTSIGSFIGALYARDADVVPMYGRAKKFSGRMGSMWRFALDLTYPTVSYTTGHEFNRGIFKTFGDSQIEDFWLEFYCNTTNISRSRAEYHSSGYVWRYVRASMSLAGLIPPICDEGSMLLDGGYIDNLTVAHMKSLGADVIFAVDVGSIDDNTPQSYGDSLSGFWSMLNRWNPFSGIPNPPTLSEIQARLAYVSSIDNLERAKSTAGCLYMRPPIDPYGTLDFGKFDEIYQVGYAYGKEFLDRLKNEGSLPIPEETEEKRKLQRTMAPRRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0I6</accession>
    <name>A0A1Q5U0I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0I6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0I6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="328" mass="36080" checksum="EB62645C31FE516F" modified="2017-04-12" version="1">MNGDIRNPTDNKIQVHVLAVGITQQVRNRAAHEHPVTSFENIPFDPSTEGIVQNKTTGDMYYVLPRGPRLLSERINLSKENLVKLTQNTDPIRAAGLLGPWLTSLSLLHGCQQRKVLIIGVTTCNGRVAAIIARWFGASAIIGISDDNDALMTVPGLNIRAHITNPIRIPNLKGIDIVLDFMGGETGNQILTQINNAPGNGTLFSLLPAKEIKYAPAWGPRAGDPFVLDAAMIAAKNITIIDPSLALWLLTTPNMREQLQTGLVLMERLQQDPYEIVARPMADIEKVWDEEDFKSSKKMLVLLPSKVKEKVEQKALSRGNCMKSCPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0S4</accession>
    <name>A0A1Q5U0S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000600">
        <property type="protein sequence ID" value="OKP06073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0S4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0S4"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="15"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="45320" checksum="4E79D3D0D4DF0ED8" modified="2017-04-12" version="1">MQLPKEFLGGVGGSFVLIQLLFLANMGYLYGTAFNDSQRIKALKLLFVDYDHGIIGQSVKAAYSELESADFPTLTESPSIDYPSASDIQESVCKGHYWGAIYVNPDASSRLSAALASPETAETYENSQALSYIFNGAKYPAYAQTISSSLQILVQGARAGYNAVNGTAAMSKLNMTDKNIAQILLDPVSATYNDIKPTAQGVRFYYNTVTMVMVILPQFFFTMALNGISAETKIFQTFSLRKNISLRLGLSVCFTFIASLCMSGYIWAFREDWGTTSSQFGLTWMIIWLVMHLNFFIIDSATAAIPAKFMPFFILTWIIMNVSSTLSPFELSPGFYRIGYAVPAYELYQVLLDIWTHGCNPTLYRSLPILFAWWLVSMVAFLAAMRRRILSVSTKSGDPNTFNHEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0S5</accession>
    <name>A0A1Q5U0S5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybenzoate 6-hydroxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000600">
        <property type="protein sequence ID" value="OKP06076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0S5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0S5"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF236">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="10"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="453" mass="49885" checksum="06D2B828B619270A" modified="2017-04-12" version="1">MEREQDTGISILVVGGGIAGLTFAIEAHRKGHNVRVIERRLRGETAGEMIVITSPALQTPKKWPGFMERARQEAVAPVVTMKKFDGTLIGSFPIGNPDDPSLAIYRSKLHNVLYEYADQLGIPIEFSLIASEFFEADDYGGVVLSDGRHLTADVVVAADGVGSKSWKLVVGSKEPPISSGFVLYRVTFPVAPALENPVIAAELEGFKDRAFLHAGSGAHIVTCKSEKDICWLLTRREDGSNAEEDWAKTTSIDKALKAVEGWEPFVTELIKATPNHTVLDWKLMWRNPQPRWASPGGRVVQIGDAAHPFLPTSASGGTMAMEDAYSLAACLHIAGKKDVSLATKVHNHLRFERVSCAQKMGFKNREVYHNTDWDAVAKNPEMMGKMVGDWLVHHDSEQYAYENYGACAEHLLKSTPFKNTNFVPGYTYKPWTVEELLGASESGEPVEDEGDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1T9</accession>
    <name>A0A1Q5U1T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1T9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1T9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000924">
        <property type="entry name" value="Cell division protein kinase (Ctk1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="108"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP06427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="432" mass="47704" checksum="F33A62B0C78FEFEE" modified="2017-04-12" version="1">MDWRSELGFTDRLRAIQSLTTVYQQTSSSAAFAEAQTEARRYETEAYDQATSKEEYDRMCQQAIDAAEAIAVRLVINSSEQVQDVSGETDTEPEASPESSVGETFGRYTSCFHHFDGLHSTIYKSKAEDGTVRAVKITIPHLMAAPHDVQREARLLREAASPHVIPLVETFNLDGGRMVLVFPFLRYDFAHLLQRDMVTAAQTRSILRDMFQALEHIHKLGIIHRDIKPSNILMNSPDGPAYLADFGISWKEGDPGSEPSDLKITDVGTTSYRAPEVLFGYKGYGTSLDLWAAGCVVAEAIAVGHGELFDSGPVGSDLSLIHSIFSTLGTPDETTWPDVHVLPDWGKVEFYTVLARPWEDILPAVSSNGRDLARRLLRYQSSERLSADEQSGAVPSREKRGSVSTIAAQNATMGTAQYISRGMTVTWSLYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Y8</accession>
    <name>A0A1Q5U1Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Y8"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62174" checksum="5017449B69CBAF9E" modified="2017-04-12" version="1">MSRIKWLLNKAAVSNEPGLSNAQMMLTNDDLRPVEPERRQWRWLNYIAFWIADSLNINTWMISSSMIVDGLSWWQSWLCVWIGYFIAAGFVCLTGRIGAVYHISFPVTVRASFGIWGSFWPVINRVVMAIIWYGVQSYIGGECVTLMIEAIWPSYKNLHNSLSASAGVDTKNFLSFFLFWLLSLPALWFPVHKVRHLFTVKAIYSPIAAIAFFAWAISRAHGIGPIVHQGSSAHGSTLAWVFVKGVMSCIGNFAALIMNDPDFSRFARTPKDALWSQLLTIPIGFGITSFIGIIVSSSSSVIYKGDPIWNPLDLLGMFLEGASSGQRFGIFVIATGFALAQLGTNISANSVSAGTDLTALMPRYLNIRRGSYICAAIGLAMCPWNLVVSSNQFTTYLSAYSLFLSAIAGVMICDYYIVRKGYLDIKALYSARKTDPYYYTMGFSWRAYAAYFAGIMINIVGFAGAVGRNVPVGAQYIYNINYFTGVLVSGGTYWILTHFFPVPATSDHWNEVDIDIDDYGVAYGQPVSDEEHVGYDRRSITDSLPPDDQKKGANTAAKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3D4</accession>
    <name>A0A1Q5U3D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000584">
        <property type="protein sequence ID" value="OKP07002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3D4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3D4"/>
    <dbReference type="OrthoDB" id="2580841at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39830" checksum="EE3039D1271FA93D" modified="2017-04-12" version="1">MPVDDYGVWKGLPVHYEVEDRFEDPKSPHLSLYYHDNREMEPQFDRKYRQKHKNKPPNKDRPKEIPGLFRAAINIKSIDRDSRIAYWVNYNLSEHSMVQNLAKVDYGFHDLEELEGHGLDYIRSHLFDAKKGRLLRHDIDGPNNDMIDVLVPEVQESIKKQAEIYIFGSRFNTRNGIHNVHMNQGNIEKFRQDDGTFQDGGLLIHYKETGQWTGIFLAFASQAVHTDDGSGHAISSLTWGQFLPTELTENSVVIKEAVVQKRKSVTLTNLTNHKVSLASWKLHTSAGQAQELPGNAVLNPLSTGCFGVPNLRLSSNGDLITLLNEDGLKVDGVSYNSQQGNMESRPIVFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3W5</accession>
    <name>A0A1Q5U3W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vegetative incompatibility protein HET-E-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000583">
        <property type="protein sequence ID" value="OKP07145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3W5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3W5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="225"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP07145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66014" checksum="4D30B456CF2690D1" modified="2017-04-12" version="1">MQAILHQLYKAQGSLAKHASKHLTSGHSLDNLATLWEIFTRSVSDSHAKPTLCFIDALDECEPVSREQLIRLMLDSFVTWGDGPVAKILIKILITSRPDNSIKVAFNKAQNQVKLGQSRSPQSGETSGPFCSMIRLRGEDETEAITRDIELVVKAAINGLVVQGFPEKLLTDIMAELIDRADRTFLWTTLIIRLLQERTEAGASQRDLRAILQSRSVDAIYTELLKARKDPKKARKMLQIMIAAIRPLTVAELSVALAVHPDHDTFAVSESSTRPSLQTFDNVNSDLVYPLENHVKALGGHFVRIIKERVYFVHETAREFLLRPTAQYRNAATTPTCDARSPNLQGSEEMSGLFEIELGEEAPVFSGNTINDTDNHAMAEGLPLSPFNDYSNSGHQCIVEEGSVWQHTFSFSVSHALLLEVCVTYLYCLAKNSKSGERGQPPTGNIGEFFRYAAKSWISHFHRVRTRIPSNALPYYYGLCHPKFHGFRVWIQEVGLNPQTMLSGALGSTEDVQDRLLRLFQLDPDDVDLSRSGNDIDDDPIDTTEIAGPAGLPDVNSIRIRALSSNPSAQRVHNFPTHVDEFGFVSLRPKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4F8</accession>
    <name>A0A1Q5U4F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4F8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4F8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012321376" evidence="2">
        <location>
            <begin position="18"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="225" mass="22029" checksum="1FF8FECFBC3C17BD" modified="2017-04-12" version="1">MSIRSFLILAGVVTVAADQHLADSPFLNQFFVDSGYVTISTAGSDATHTTYIAKCDNSGANVCTLPTAGATIVTGPSYVGASYTDLSETLFSSVGCGYINAGSSALCTVYQSGQSGTSVVTLSQTETLPAWAVALGFNAPTGTSTSSKQTTEAVAGSAATVTTGAATTVESGASSTKSSTTSGSSSKTGSAASETKAGGAAKLAELGNVFVAVGAAIMGGLALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5F2</accession>
    <name>A0A1Q5U5F2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5F2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5F2"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="21106" checksum="BC837E86691F6F32" modified="2017-04-12" version="1">MFGVGDIIWVPLMRVIGKRPVYLLAMLGLCMMNVWSSEARSYSELLAARICSGFPAAAADATVPAVVADMVPAKDRGHCMMIFHLALTSGLFVGPLINAYLIQGENWRWMCYFLAIAVGIVFVVAVFTIRETSDIKRHNSDPSRKRSHWEWMSLTLGFNRDASFLRAFLDILGNATYPPLIWCSLTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9Y1</accession>
    <name>A0A1Q5U9Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil catabolism protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9Y1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9Y1"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="55126" checksum="40DC5F0E37FB5004" modified="2017-04-12" version="1">MGLFKRNSKNSVQSDRDEQESFVSVNSARTSNTSLRSPGYKGSGLPASIPEMPIAKPPDPALDPAAYLRSIHAVRERANIVLHAAKRNQLNHFDVDMSKFKATAQYVVSIIKRDYAPDYQNIPPHGRWQHFDVGGRPRVNQLLQSWPSSIDSQERTRRLIDLFVVSVLLDAGAGTKWSYKSKESGKVYSRSEGLAVASLEMFKSGLFSSDPTEPCQVDGAGLKKVTVEKLAKGMQHSEQNPLAGIEGRAGLLVRLSEALNHQDFFGVDARPGNMLDYLLGHPSTLASSVPIVPITTLWSVLMDGFSSIWPPSRTQIDGVAIGDAWQSSLLPQSPPAPAWESIIPFHKLTQWLCYSIMVPMSKLMAIHFAGSDLLTGLPEYRNGGLLIDMGLLSLKEADMERGLRSFKENAQIKGQPNMEVVPLFSTDDDVIVEWRAATVGFLDELLDEVNTQLGLTGSEEQLTLAQMLEAGTWKGGREIAEVSRPNTKEPPIMIRSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA99</accession>
    <name>A0A1Q5UA99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA99"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA99"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="95" mass="11106" checksum="1A641939455A21CF" modified="2017-04-12" version="1">MAQSRILDLVKTQCRIFSLNFNPQRLRLGNKILRQRLRGPALAAWYPKKTVSFRDLQNTYKPLGLTTFDEAEDDREEAIQMSVGFYTRFALLHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBH6</accession>
    <name>A0A1Q5UBH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_4756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBH6"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="317" mass="33397" checksum="D5C2C6F47F86FF0C" modified="2017-04-12" version="1">MPLPKSEYISDIWKEGIFANKVIFCTGGAGTICSAQVRALVHLGANACIIGRNVEKTERVAKDIATCRPGAKVIGIGAVDVRNFNDLKSAAERCVKELGGIDYVIAGAAGNFLASIEQLSVNAFKSVMDIDVIGSYNTLKATLPYLVESGGKHRMDSETLQPAAGGTGGRIIFVSATIHYRGMPFQTHVSVAKAGIDSLSNAVAIEYGPRGVTSNIISPGPIAQTEGLERLLPSDAKAAYTKAQPLGRFGHVRDIADATVYLFSDGGSYVTGQTLVVDGANWRMSGGLATNGNLQYPDFLLSGEEVANVTGKKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBQ5</accession>
    <name>A0A1Q5UBQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_4627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBQ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="114"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP09915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="19166" checksum="2FE38E4767858959" modified="2017-04-12" version="1">MAAVTAPQDAPKQGLALYSRFAFAGAVCCSVTHGAVTPLDVVKTRIQLDPATYNRGMIGGFRQVIQNEGAGALLTGLGPTAAGYFLQGAFKFGGYEFFKQQAINQLGLETATNNRTAVYLASSACAEFMADIALCPLEATRIRLVSQPSFANGLFGGFSRIMKEEGIAGFYSGFGPILFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCR3</accession>
    <name>A0A1Q5UCR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4330</name>
        <name evidence="4" type="ORF">PENSUB_5122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000506">
        <property type="protein sequence ID" value="OKP09522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000372">
        <property type="protein sequence ID" value="OKP10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCR3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="215" mass="23098" checksum="701DAFA0E14EA085" modified="2017-04-12" version="1">MTAMGSWGLTPLCWAAHKGDVPMAVLLLQNGGENINARSSDSRRWTPLSFAAAKGSEDMVRLLLADERVDVETKDSAGLSPSFVAAFKGHLAVVKLLLETGQVNANSEGPHSRTLFSWAAGKGDAVVVAMLLATGSVEVNPRDRQFGRTALAWASLYRQETVVPLLVGTKQIDLNARDCTDRTLLHLAAWKGHAAVVELLLQSSRVDVQPKDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD78</accession>
    <name>A0A1Q5UD78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-hemolytic phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000347">
        <property type="protein sequence ID" value="OKP10420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD78"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD78"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012795846" evidence="2">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="632" mass="69804" checksum="7BDDA44FFD9FFBA8" modified="2017-04-12" version="1">MMLLLGTALAVLLGSSPVTAGSLRDIEHVVIFMQENRAWDTYFGTMAGVRGFDDPNVQVNSDGQSVWNQVVEPSMSTATKSLLPWYLGYQGGDSNEAIQCMAAGDNGYHDNQAALNHGLNNHWARNNTPWSWGYFKREDIPVQFAIAEGWTSGDMYQESQITSTNPNRVTLVSGSVNVPGSPQNPSQGGVYIDNNEMPGCDGNGINCYPLKWKTVYEFYEEAGVSWQLYQDTNNFDDNPLAWFDQFQKASQNSPLAKKGMSFVGLDAFYAAAANGSLPEVSFIVGPTELSEHPPYQPKDGGWLQKQVVDAVTKSPKYSSTLLMISFDETGGFGDHVAPFHSPQGTPGEWMKDPTGVFGDVFVGPGFRVPFYMISPWTRGNRVFTERADHNSQILFVEQWLTARGYKGIQTDQMVPWRRAHMSNLVNALDLDNPDLSIPYLPEADTPITNSKGDYVGSAQCQSKFREPRPPVPYGQQQANSTNALWFEDGFKEVVGYLTEGRYLVLEKGGSALTNSGKRDHLTVTPATLKHEAKSQRWVIHYTADQESEIFTISSALDGRWLGARGALLDSDQARNAEPVRITFLGNGLGYAVQYVNGNQHIDVDQAGALKIATQHHVPDGGFKVFSVTYHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD94</accession>
    <name>A0A1Q5UD94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dicer-like protein 2-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000319">
        <property type="protein sequence ID" value="OKP10468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD94"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="184"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="369" mass="41287" checksum="4309F4E4A3FA12B6" modified="2017-04-12" version="1">MPDPIPLYWKRGTTLIAKFAQPQPVEATMETIMTMRSTTFAYLQAPSSRVRAPSGDFVALFVPIIPLAQLEEWIHNYGGTEKAVDLHSRETISPKGIIRDTENYGELCLFRRWICEDDNQIYLECQSLPRRRNFLQIGTFETALPKIRVLPASGCTVDKLPAAKAMAGRLIPALLNRFEATTVANRLNDTILKGVGIQDLSHIITAITAPIAQAATDYQRYEFFGDSILKFTVSYQLFLAQPSWHEGYLSESRDNLVNNKRLARAALETGLDRFILTNGFVPREWDSPLISQKSSLHASKRKRNLSIKMLADVVEALIGAGYMDGGLHRAQACLHCFLPEIDKFTSTNAVGEVVSTTRANLMHDTTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDP1</accession>
    <name>A0A1Q5UDP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_3876</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDP1"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="66"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="347"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="46665" checksum="3DDA0CB3E935B6E3" modified="2017-04-12" version="1">MKLDAKALRYLTSEDFRVLQGVEAGSRNHEVVPTPLISQLSGLRGGSGVHRSISNLAKTNLIAKVKNAKYDGYRLTYGGLDYLALNAHQKQKVVYSVGNQIGVGKESDIVVVAHSSGSQRILKIHRLGRISFRTVKTNRDYLRHRNSGSWMYMSRLAAMKEFAFMKALRENGFNVPEPIAQNRHTIVMELIDAFPLRQISKVPHPEALYSELMDIILEFARFGLIHGDFNEFNILIKEIADPSGKGKASVNADEESDENVRLEPVIIDFPQMVSIDHVNAEMYFDRDVNCIKRYFQRKFHFVSDAPGPFFADAKKNFMKNPGKRLDVEVEASGFSRKMARELETYMKEVGADGDAGAARDDLDDEEEDDDEEGSEEEEEDDDDEEQEQAGQSSADVDESSNRLETLQVSESSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDQ6</accession>
    <name>A0A1Q5UDQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">U1 small nuclear ribonucleoprotein usp102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_3903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDQ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDQ6"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="251" mass="27389" checksum="838BD44F27720A8B" modified="2017-04-12" version="1">MAATGQSTGSVPPNSTVYVRNLEERIKIEQLKVALEEIFSEFGNVVEIVAKKNLKAKGQAFIVFDSVDAATRAIEDANGFELFDKPMVLDYAKTKSDATVLREGGNDELEAHKRRRLAEKERKQAHEALEAQKKLKRPAAPAEGARPAKTTKGAGLKPTTGAAAAVVPDEYLPPNKILFLRDLPDEASQEGLSDVFGRFEGFLEVRLVPGRKGIAFVEYETEAGAISAKEATSGMAMGDQNQPIRVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDX2</accession>
    <name>A0A1Q5UDX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDX2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDX2"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="304" mass="32033" checksum="06AB50821F2CDB32" modified="2017-04-12" version="1">MSNLQASNLFSVQGRVVVITGGGSGLGRIMAKALAINGVSKIFVLGRREDALRETAAQAADGVIVPVKCDITSNESLVSAYETVAAQTNHVDILFANGGILGPLMRSPPPKADGTPPSLSELRDELFNIPMEEFTNVLNVNVTGSYYTVLAFLPLLEAANKKRPAPQVGVLTAPTAQVIITSSIASFNRKVPFSYAYNASKAAVTHLVKMLSTNLSSYDIRVNGLAPGLYDSEMANNVFVENGTQGGGISEGSFPRDMIPLTRGGSEEDFAGLVIWLASNSGGYVNGTMLLTDGGRISSVPNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEN5</accession>
    <name>A0A1Q5UEN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEN5"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="22267" checksum="D91852C920D08676" modified="2017-04-12" version="1">MFENPSPSFDVDWIDEALTFEYVTQLIGRLICLEEAGENFSGVDYWQKHIFAFKVLKDDWCGESLTSFVGFRERDFEALTPPYNGVDDAKAEPESKSDPESEEYSANYKKAAFLIWEMLANASMWKVPHAHELTHSVQLVTLLDLQENEGMDAAPGTFGKLFRFGTVNLRQTREGIEMMPTPRPSQTWKKGVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF31</accession>
    <name>A0A1Q5UF31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="16010" checksum="DF2A6CC7A160D4D9" modified="2017-04-12" version="1">MLNNLVVRWVCEIYNASRARCPPRQHLRMPLLVMLFGGRIDWCPMRLNIFFSQGPSLSIYYQSAPSSPNVRGVAGPIGMSVRSTSLSDCASRLPPPTILLLRKGRSSHGVMTSIWTPYILGKRRKRRRSVFRRRLVVIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFC5</accession>
    <name>A0A1Q5UFC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFC5"/>
    <dbReference type="OrthoDB" id="10042947at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="14676" checksum="FA80FDA5A95D5905" modified="2017-04-12" version="1">MPSKQGQPGRKPFLLAPYVFGIQTVPLLASGIYTLLYPAAAASLPDSPLQGLSNGTIQALSLTSLSLGSFYAIASYQNNIPMMIAAVPGRLLAMVVFHRSGGGWKSVAPFEGVMGLLTAFGLWWDWRGFGVKDEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGE5</accession>
    <name>A0A1Q5UGE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">N-acetyltransferase eso1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_3027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGE5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="11">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase ESCO acetyl-transferase" evidence="12">
        <location>
            <begin position="324"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="396" mass="44474" checksum="9F96DE1692E876F0" modified="2017-04-12" version="1">MKTYGRPTWRVYDDERAAKKRRVQDESDEAETNLQYAIRESSAAVLSSPSRRNSVVLSEGTLDDIDDLTTPPSSPPPRLSPPPANTRKPTFAFLKRKHKEATAGSPLTEVNSNSVRSSVDPPKQQQQQIHSHPPPPPQPQKVTPKQPALRQMQIDLGTEVRKTCATCGMEYIPSNTEDAALHKKFHEMNSTGVDLGKAFMRANASRWVYEATRFEEGYVVIVDRKATPSAKNQAKKVLEVVNKELSSPEIEDEVLWSQAEPPKHLHTDNNEEKVDRYRVFLHMKDSRCVGLCLTERIWEARPVVQGESNGHANGSSVSVKDEVHPAIVGVSRIWTSGASRRKGIALDLLDCVVSNFIYGMEIPKDKIAFSQPTESGKKLAHKFFEEDATWHVYNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGS8</accession>
    <name>A0A1Q5UGS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sphingoid long-chain base transporter RSB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGS8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGS8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="165" mass="17934" checksum="31EDC22F65F8E3B6" modified="2017-04-12" version="1">MAVPLVCALNKCPIEWGYVHYQPSVGGNAFICAAFGLLAAPALYLGITHKVKLFTFCFVMGLLGEVIGYIGRILLHNNPFSKDYFLIYLICTTIAPTFTAAAVYLTLARIVVVYGEGISRLRPRTYTLLFSGFDLIALVVIAVGGGMAAVVVLQWKVSKYLNSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGW1</accession>
    <name>A0A1Q5UGW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U4/U6.U5 tri-snRNP-associated protein snu66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGW1"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="673" mass="76516" checksum="A4E9F1692EA8C590" modified="2017-04-12" version="1">MADALSIEQNNKIRVALGLKPLPVPGAEADDATGPQFKDDASDADSDEEPASTIETRQAQGYDNWKKLQDEADAKRKREEKNAAIKRARDIAQRNLKLQGATLGESDGADLDTKAWLMQSKKRSKKIEKERARKLAEELEERERLAATEYTAEDLAGIKVGHAIGDFEGGEDHILTLKDAAVDDEEEGDELEDINLVEKDKTTEKLELKKRKPVYDPTAENQGILAQYDEEIDGKKRKRFTLDAKGSNEEEREFKRQEVSAGLKKGVFSLDLEPEIQTSDYMDISEVKIKKPKKKKNKTTKQRAVMDDEDLFPTDTNTPNGTSMDIDSTNGASVTAARKPISEEVSFADDDDLQASLALQRRAAFRKRKKMRPEDLVRQLREEESQTPMETDTPEDGAEEPGLVIDETSEFVSNLQRPTLPEREERRTATPAAEAAARSEPDEEPEDVDMERSYNDIEDEEDLKERLKREESNQAAQQLTGTGLEEESTLDQGLGATLSMLRQRGLVKETDSSSSNALLRDRQRFLQDRLNREADAERRARTQRERDRASGKLDRMSAREREEHARWENKQRDQQEARQMAEIFNREYKPDVQLKYTDEYGRSMNQKEAFKHLSHQFHGKGSGKMKTEKRLKKIEEEKKREAMSALDSSQHTGMNNAMGQQARKNRQAGVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGX3</accession>
    <name>A0A1Q5UGX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_2807</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGX3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGX3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="313"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="214"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="495" mass="56745" checksum="43A7FFCEF3FF5AC3" modified="2017-04-12" version="1">MRPAARSCAPFVPSTRSQLWLRGLGTQSLAARSRPIALKACLQSSPERRIASSSTRESWTPGISHTSLARRPRALAPSQARFFRKVNYVEKIGDNEKTEEILETLEVKDDEQDDRPQRQILDEEGKKFPPPKSQMEKWSEHMTQGIEPIAILVHPQQPLSYLERLIQSEVPPIEGETIKRPPAVSFIALQHEDNAIKPRKRIEDDLDVEAAYDEATSKHEGDDNGQKPGSGAPIQRRRRSREEDVETYSYPRKTDSSLDPLNGEPERFVRWSQATEVGDFIRDAARAQEFIVTIEGAPAGLGQIRVTVPSFNERTYFLRMRLRKLSQQIQGIAEIKHECDAMAHRGAQRVAIGGFGILATWWFTVYKLTFETDLGWDTMEPVTYLVSLSTLMGGYLWFLYHNREISYKSALDFTVSARQRKLYQQHNIDLQLWESLIDEGKALRREIKSIAAEYDAEWDERVDEQDERVTQALRSERKKDDRKKSSSDKDGEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHZ3</accession>
    <name>A0A1Q5UHZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000247">
        <property type="protein sequence ID" value="OKP12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHZ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="167" mass="19854" checksum="6394278A8771EB23" modified="2017-04-12" version="1" fragment="single">QLKRKRVPWKATIRRALEAGRQKLSDYYSQTNAHSNLYAIGTILTPRYKLQFFSKREWSDNNYQWRKTYRGYMEKYLKPYQQRQKETEQSQFSRPSTQQKDNIELLLDDNPSEPSQSQEKRTGPVFDDELTHYLNSAVLVWSVFLTLLVTYTTIDGVVLTRPLYKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIM8</accession>
    <name>A0A1Q5UIM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="248" mass="28554" checksum="97F2D30BA3C2DC28" modified="2017-04-12" version="1">MPRAINHAELRTQFHTSVCRLMNQLKRFSSYVLKVDELMGLGVHVSEFDPFELNEAIIFQPLAEQELHDYVIDEIMLQNDDIVKKLDLPDWTPPEASKVVSRLDEERAALKAAEEAYEYLEAMYSCLSKSYEPKNPLSMARNWTDIPIPHPEFTWPRELGFNSWPRDTGLLNHNSLEHVGWRYQIVSEWKDTPRRGDPKARPHVRIVVCHGAIGTPNGILLGEIGAIAQAIYNRLNQPSFENESYFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIX3</accession>
    <name>A0A1Q5UIX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIX3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="2">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="354" mass="39431" checksum="207DD2E75A01E022" modified="2017-04-12" version="1">MWSSTKRPWPLAALIFTLFCLAMIWMGSYRPSFPHPPSVEPSSTVEWSSTVEWTNAVESSIVGSSSATPSVVPSNLEQHVVELSDNKTSNSTLGFEKIFFISLPHLLQEKVKPEGSGNLRPEQLGCWRAHANVWKRMLDENIESAMVIEDDVDWDINVRDIFADMSHQLAQQTLFPNLVPQPDAPYGRDWDLLYVGSAWDIPNNDNRPPHLLYHDPNAPTRENTGGSYIGELEGWGAKVTENTRHRLIAPSWYPVSTIGYAVTKKGAQKLLYNLGGYKGLSAPVDLAMIGLLQKGVVDSYTIIPPIITRYRTGGSRDSDIDEVKPEDAEAKTGSENLNMGARKAMEKLQEKSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ28</accession>
    <name>A0A1Q5UJ28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ28"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ28"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="136" mass="14955" checksum="F8CE52BA17658495" modified="2017-04-12" version="1">MLSTALIIDQTGITDAPNSVKSLPNLRSVAVIDRTADVEKAAQQILPAHLAFSGQSPHAPDLIIVNEWVKDKFIDTMTQERLRLNREVRSSHADKHVAWKKAVTDAESKGEAKLIKKEGLYMVDVQQSLADAALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJJ3</accession>
    <name>A0A1Q5UJJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJJ3"/>
    <dbReference type="OrthoDB" id="3800761at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13764" checksum="E26E266AD96C3843" modified="2017-04-12" version="1">MTLPDRDVMPPPTSPTSFDKSGTLPSAHLSHPAPTPTSRASRAQSEKLDTNSQTFLRRKCKGYQKPISVGLVAQDGDTERGRYKWQQIGLLGDDISKADNAVLLCGTCHTEFDKTTDPGYGFSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJK6</accession>
    <name>A0A1Q5UJK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJK6"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="37042" checksum="0CAAC561ED0396FF" modified="2017-04-12" version="1">MTAFKLLVVIGITGNQGSSVARAILKLPDWRIRGISRNISSDAAQQWISKGVELVKADLDDIGSLENAFRGASAVFAVTDFYSLMLDPANFAAAQAARITPNEYACNLETKRGMNIATAASSPAVAATLTHFIFSSLSDTKHWSNGKYTWNYHFDGKAAVVNRIKKELPGLAEKLSIIQVGMYASNWKGGMGRPTKQKDGAFLVQIPDIGEVQLPWIYVDRDVGIFVEALLESSPRKQILGVSQMASWREFWTLWAENRGVKLDIQVVSVEEFFQPLPELLRREFQESLKYIIEFGYTGGDPDVCCNLQDMLPGAKTATLKEYMDRENWSTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJM6</accession>
    <name>A0A1Q5UJM6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_1638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJM6"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="273"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="576" mass="65023" checksum="3CAAD68B887F600D" modified="2017-04-12" version="1">MAPSIYIDEDVGHDDASAAGTESAPYKTLIHAMVQHPPTTEGIQYLTRKSQTDAAGEDVDPAAKLEWKPATKSAMKKATNLYEQRKKKAAKEQELAIREKAEAEKRQKVLDEAKKIVITEDASLPKPVRIRLDVTDPAIVSLRTPESDAPGTRVRVLGRVHRMRAQKDYVFLTLADGYGYLQCILTGDLVKTYDIMTLTLETSIAIHGEMRAVPPKQHAPNDRELHADFFTIIGRAAGDKEAITTRVAPDADPQTLYDNRHLVLRGETSSSVMKVRAATLRAFRTAFEENRMLEVTPPAMVQTQVEGGSTLFGFDYYGENAYLTQSSQLYLETCLPSLGDVFCVCPSFRAEKSLTRRHLSEYTHIEAELDFITFTDLLDHLEAIICRVIELLLADPEASKYIKTLNPDFQPPSRPFKRMKYSDAIDWLVAHDIPNEEGEPHKFGDDIAEAAERKMTDIINTPIFLTHFPAEIKAFYMKKDESDRRVTESVDVLMPGVGEIVGGSMRMDDWDELMNAYKHEGMDPKPYYWYTDQRKYGTSPHGGYGLGLERFLAWLCARYTVRDCSLYPRFTGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKQ8</accession>
    <name>A0A1Q5UKQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="361" mass="40577" checksum="09B3A3BA3DBEF37F" modified="2017-04-12" version="1">MGEANPDAPAPRKRGRPRTVTDDQQVPERRRTQLRVAQQAYRKRKEATITTLQSRVQELESGIEELSESFLSFSNLLFEAGIPQNHPRITSALQKLTQQCVSLAKNSSEQGSPAEAPLTTTRNLSTIQDIDPTYDPHMTQLDSLPITHETFQSSPKSFNQWPVSQQLPPTPPYQEQAILPFGIVLSSPNNPYPPRQSPTLNFPTNVSPKDLMKQERWTLSHRLVRQCCENAYRLLTRTPMEDPRIQEIFGKPLTIAERNSLTSGFYSAMHDENGDSIELKAKALSPLHMRTNSYSPEQLAISSRTWQLVIESGTDQWLDASGVQRLLQERGISIHDTMSPMSSPRSSSAPQLNVASFVTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL19</accession>
    <name>A0A1Q5UL19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_1262</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL19"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL19"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="37248" checksum="934E79BB8EE8E18C" modified="2017-04-12" version="1">MAYQQERYIAELAVQRASILTQKVFFEKAKGTVSKDDKSPVTIGDFGAQALIIQAIRKNFPNDEIVAEEEASSLREDKALSAEIWRLVKDIKLEDAESDKILGGPIASEESMLDIIDEGKSAGGPKGRIWALDPIDGTKGFLRGGQYAVCLGLIVDGDVKVGAIGTPNLPVDDAAPIDASTGAQQTSTSANGVLFSAVQGEGATSRPLSNGTLAESKSISMRPVPDIAQAVFCEGVEAAHSAQGDNAAVAERLGITAPSVRLDSQAKYCSIARGAGDIYLRLPVKKDYQEKIWDHAAGDIIVREAGGQVTDIYGNRLDFSKGRTLAANKGVVAAPKALQDQVIDAVKVVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULD4</accession>
    <name>A0A1Q5ULD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULD4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="926" mass="104000" checksum="FB7518D27EC646DA" modified="2017-04-12" version="1">MDDTDSLKDAFVSAARSACDITESLMKASAPYKDQDAEIARFHLHFEAYLQSFRRFKTGFERFILQTPDKNNTITRDRILVALSRIRANIETLQKNEGLFSTFLVSHVELVEDLLCAPEMFGVIAVNLINLKGKFKWAAQAIGSDEATLKLAKSKEATDFLDIISHEAQQGYSPPLKLQGLGDMELWSNDAESSGGKATVHEAAELDLPFDSEYTVPEEANTEPIISGHGRELGSKDNQYHLSSTDYLFSDIEMWKTSRPKRNHADELGTDQSRDLTMDLARIGSGEEEAGRVAALELGITWPSSWDTKSIEEDSEGYESFDPDDVSNRVVETCKLCNKMKLVEWHCPKCAGFEPREVPMLLPPTWMLRESSSEDYQRSTAKGNKEAWQNPSETQGHASEAAGSLDDSDKDSTKAEDSESDTSNPPSVFSLATLPSTIMTTDTRLTVDEMQTAIEELVGIFFDDTEMTGLYEKAIVEREVSLERFVRNFRRLLKQFALNLKEEAREAIELDLSKLILMRARLIADKIGNKLELKYLNEPPTHLPLSPFIPLRTPSVTESFKLHIMAQPSLPEGIIESSSDEDEEPAETFTALVSHGRDFILESAAIKNLQKDLANFIFPDGPMVGADIKLEFGISKMRGGIVFRRSTRLWGFPLIDMAATRARFRARGMERYWYWNKFFQLCQVEEDLPEKHTRFRWTNVSLFSWAILSFKDANMSQRHGKNLYDDYVEHEPGALQALQEFLKATTVPTYIVAKGTEIQGSSSAAARYTPNSGGLQATPCASTPQGGGNVTQSAITTPGGQPAIASQHIGTGIQESRPLLLLCCIERRGRPIKLHQEYVTQITDDRQLFHALRKIYFSHRRKFESFWSLRKLHSIHFMKTFAVIQKSASPANPAPAFHHQPSSHPWAQPINADQSPRNTPHQSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMD3</accession>
    <name>A0A1Q5UMD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_804</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMD3"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="244" mass="26762" checksum="337731037CE92D42" modified="2017-04-12" version="1">MATLAPYVVPALTKHTATVIMAHGLGDSGAGWMALAQNWRRRGKFNEVAFIFPNAPNIPITVNFGMAMPGWYDIAHLGRDLDFQDNVRNQDEPGILRSRDYFNSLIKQEMDKGIKPSRIVLGGFSQGGAMSVFTGITGKEKLGGVFGLSCYLLLSDRIKSFTPEEWPNKKTPFFLAHGEDDEVVKFAYGERSAKMLTEIGLEDVTFNTYSGLGHSADPVEIDDLEKFLEKAIPPEGDGQATAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN20</accession>
    <name>A0A1Q5UN20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN20"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="476" mass="53980" checksum="3292EEDEC33DFC46" modified="2017-04-12" version="1">MVGVPYSKGCLLCRERRIRCDQSMPQCLQCRRYGVACPGYKRAWQFQDEGPRLQRRYQKKFPIAGNNNVRHEPEAIRRRGIITRNQVFTNLSIDERVYPALIQQCFISQQPRVFKEFTCAAFPTMFFHNEFRFGDGFTFPDWVVKHFGKKPYYDAAVSCLSAQYLAHLTGDPSVNHFSRQKYSQALAAIRQVLNSDEEASSDALLIAVILLSFYEMSTRTTRDAWVCHSRAVKHIMMKRGMDLHLSGAGRVCHFAYRPFLIAAAIYEGEPCFLGEDDWQDLAAVLRAEDSQKKSEWSFYIDVYESIFMELVKCPRYIQEAREITSLASSKAQLLEGSIAMTCDRLRALNDELRSQLASNNQRKLGIVFRGFIGPEPNGFPETSPSLLLSAAANTLEILEQLRARLQISVSFKEEADCLAPSSIPQSTCTANVSLPCLDFRLVCELGEGIQKDDPRAFTWLDRVAGSMGLLGAKAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNQ5</accession>
    <name>A0A1Q5UNQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNQ5"/>
    <dbReference type="OrthoDB" id="4356605at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045425">
        <property type="entry name" value="DUF6508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20118">
        <property type="entry name" value="DUF6508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="226" mass="24883" checksum="2D0A42060BE3674B" modified="2017-04-12" version="1">MPLTTPTPSTAVASAIAERLSGFAYAQGASVTFCDARRRGEPGIYEARNGELALATQGTTQVQRSFLAEIFQGEFDRYDGQDALYFTTQCPVLHAPSYLASSSRIDHNATSNPAIAGYIPRLTKLAELVPILSQGHPFATVEESILDVIHDWSKPGFNWVDWNQSDEATKLHKTDLLDHATPAQLEKLLTAIVRQDRFLEGLIERTYKSRLLLRIAGRAAAILQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP25</accession>
    <name>A0A1Q5UP25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_77</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP25"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23653" checksum="A4C94E85074B2FA5" modified="2017-04-12" version="1">MAAPSDIKIENLTGTWMLDKQLSTDSDPLLALVYSATQYLPLLTDFLQQGVNWVVRKAIGMTEVTMKMKQFEGSSPGTGSAVTQIAISQTANVNLGGTSESRYLDWQEYPQEDHIFGKTVVQSRFIGNSNQAAKSVPCVHIRTEINDPEVLKFLRGEIDESYAPCDGFLVEKSQATEPLEGGEDGLWIHVVIRSHEPKWIAEQASDGIYPSCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP67</accession>
    <name>A0A1Q5UP67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucan endo-1,3-beta-D-glucosidase 1</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Daughter specific expression protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_41</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP67"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1170:FF:000001">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.420:FF:000008">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384551" description="Glucan endo-1,3-beta-D-glucosidase 1" evidence="17">
        <location>
            <begin position="23"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="18">
        <location>
            <begin position="165"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="19">
        <location>
            <begin position="498"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKP14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="859" mass="93033" checksum="2765CE8389327CD3" modified="2017-04-12" version="1">MAAIWKTTAMLTWLLAADSVNCLPQPAAATAEQVLKQSATHPDSAFKTQYPPSNQRIAIPAAEPDYRVILDNRGHPSQLPFPTVDVGRLLDGIGGLLLPPSTSLPAVHQPTDTTDTPNDNSPDPASTVVSDPISTIPVGTMNNQNIFEPVATGAVPANIKTRHDHPVQNKHANATNPIETNKFYAGLFLGSQTNSSFTQPYSVAWSRGGGNLKSWGMSVSHVEANVLAYGPKNPTLPGSPVGYYINPIGLQHVILSASELDESSVLNVEEPKAFSANAVLKRSGGSAQSITFPIVQGMGYVTGVYSDLQPLVESGIFFRKVVNAGSPKPGIFKYQLFLEDDTVWLLYATPDDGKDPEFKLVTSSSLRGPAGFSGTVQIAKNSGGIAGEKFFDNSAGVYPVEGAVSGAVTGTAGTYSLSWTKAGKNAQGTPLIMFALPHHVESFDVSTRARATDIHLRTTTKGNATAVIGESWIMAEPDLPMDMGFAPWSATKGNVHTLSADAQRAIVQIAPVELQQDIDGQTNLNSMYYSGKALSKFATLVWTVSNLGNNPDVAHAALVELKKCFARFVQNQQQYPLAYDSVWKGVVSTAGYDGDLNADFGNTAYNDHHFHYGYFIQAAAIIGSLDPTWLAQNKEWVNMLVRDAGNSVEDDPYFPFSRSFDWFNGHSWAKGLFESFDGKDQESTSEDTMFAYAIKMWGQTTGDASMEARGNMMLAILRRSLHNYFLMESNNTNQPSNFIANKVTGILFENKVDHTTYFGSNLEYIQGIHMLPLLPNSGYTRQPQFVAEEWQAMFAANASTPAADVDGGWKGILFANLALVDPQASWDFFAQHKFDYSWIDGGASRTWYLAYAAGLGGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPZ9</accession>
    <name>A0A1Q5UPZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPZ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPZ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="9513" checksum="A9E79F74D6415D51" modified="2017-04-12" version="1">MSPKYGHLSQSRASTRVSLRWLPGPPFENTETLVLMVGEWYVDLRVDKESGALGWAIAGQYLLKDTNPRMCRFLSVGSSSFCMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ07</accession>
    <name>A0A1Q5UQ07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ07"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="21606" checksum="8A1F52506B57F583" modified="2017-04-12" version="1">MASNRNITIFGDKRVNFVNSLLFWSEKLSHPGQTIQEAVKFLHGFEVDFDRFRVIGEAESASFCFLLKCQIITHTIQDAIDILRTGRLFSPHEVAEILSMTAQHIGRLTLSKQDNVDLYAEHMDQEAGKVNLMWMSRKALPDAQQERQRGKLQEIWERLHFTMPDCDCVQCSRGPWPLKKRAARLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQA7</accession>
    <name>A0A1Q5UQA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQA7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQA7"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012140655" evidence="2">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="348" mass="35340" checksum="589F97240E8C4F22" modified="2017-04-12" version="1">MHFSKSLTLLAALTSSAVARHGHNALHEGHLRRGDTGSTVTLTTTNTVYVCPCDSSTSTSIASISTPIPETTSTSTAVLTTSTSTSTSTSTSTSISTSISSSTSIELSTSTVASSTSTTAAASTTSSGASADWTSVPSSGEYCTTGFGGVTKSSGSGDTYVGNVGSPYGTNIQEVSASEASSYKYVVQFQGSNTEAWKVVIWNKIGPDGKMDGWYGKACHSFTLAAGATKYYAFDTDSQGGWTAAKASIPTNAYGSYASTWGEFDFGSTANDGWSGFDVSAIQAQKADLTVQGMKICSALSDGTCSSITKGAGTVDNAYTSALADKGGIGGNLVAGPVRLAVTLDYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQP8</accession>
    <name>A0A1Q5UQP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_5864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQP8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQP8"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="264" mass="28479" checksum="2C95AC6B5B9627E8" modified="2017-04-12" version="1">MENENDSFAEEFLDACYDGKLSKVQEALATGRLSAENLGEGLETATEVAHTEIVAALFDAGVGISTSAIDSLPGANLTQHVGIVLLFFKHGLDPNAITSDGEPILKFMNDPVCAREFLSRGADPNRIGPSGIPILVSAIISSEDTSRIEVLLEYGAKLENEYLFAAFRRRVRQKLLKTSFLLAKGLDPNQINAEWGTPLHCAVANGSPGLVKMLLDAGADPTVRSTGKQYYGEPPLAAAEDIPIPKNKEEIIAFLQSWQTTVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR39</accession>
    <name>A0A1Q5UR39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR39"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR39"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="479" mass="52297" checksum="08A99F7F39E6A2E4" modified="2017-04-12" version="1">MAPSTQIDELASAIVARFLRTNAYTETLKAFIREAGLAPDVGQASGDDTHNLTIQSLLEEKKAYDHSVNFERLRNQSREISEWGLPELWQNPGRDENDVDADPAASTRPFIISTGADRQMHLLETISGNEAITSFSGLSDSPVLSFVSILKGRYILMTNMSGHLLLQHGSEVLQSRNDHAKYAVKVVVHEELDDTGSARVFWVATAGWDATVFLYRMTIPGDQASTPVIGDPAARIKLATNPESLLFVRHVDTGDLLLLVSRRDSSYIYYYQVESSLQDSTEQTDSGNPQNSPRECRLLGQQNLAPHSNAWVAFSPSHMALSPLDPGLLAVATSSEPHMKVIIVRLLFPSTISPNTTAPDAAVTQASQALEALALQNREDAAILIQANTFAPQTSYSTPQVAWRPDGSGVWVNGDDGVVRGIEIKTGKVVALLKDGHEPGSKVRTIWAGYVAVPNNGDDAKEEWVISGGFDKRLIVWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR54</accession>
    <name>A0A1Q5UR54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000039">
        <property type="protein sequence ID" value="OKP14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR54"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="112" mass="12684" checksum="780CE8D229A139EF" modified="2017-04-12" version="1">MLDYPQRLDECSTPKFSRKVYLILHKYIDHNEGGFSETLQRTPGLKKTLEDLLWLQRAVLNTPNPLDGVNHTPQSSTSGPTMSLCKLLAEAEECAWIIIDELPHYELNALGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URB8</accession>
    <name>A0A1Q5URB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin-activating enzyme E1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URB8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="9"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="6">
        <location>
            <begin position="271"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="7">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="614" mass="68228" checksum="95C148281E68CB42" modified="2017-04-12" version="1">MGASSIKRSLGVDLTNKIKESRVLLVGAGGIGCELLKNLVLTGFGEVHIIDLDTIDLSNLNRQFLFRHEHIKKPKALVAKEVAHNFKPGAKLEAYHANIMDRQFNVDWFKTFNIVFNALDNLAARRYVNRMCLAAGVPLIESGTTGFNGQVQVIRKVRCIYTPALYSEIRPNDHRLFGASEDEEAELDTTENAENAEEIANLRKEAETLKVIRESMGSEEFSKNVFKKVFETDMERLRGLEGMWTEREAPKVLIFDELQESSTSTKLPNSNGDQSEWSMEENFVVFKDSLDRLSKRLKELQAKNSPDDPEPILTFDKDDEDTLDFVTATANLRADSFHIGRTSKFDTKQMAGNIIPAIATTNAMTASLCVLQSFKVLQNDLAHAKMVFLERSGPRAINSEKLRPPHADCSVCSIVRGGISVDPNATLQDLVEGVLQQELGYTEEMSVLTDEGVIYDPELEDNLPKKLSELGIKSDSSLIIKDEDDEEKDPRVDLEFRVVERIEPLEDSKPVTLVEPLDIPRRSRKVEPEPDLPSVMNGTSTTGKRKREGEDEPLTNGHVAKKVAGESTQNGNEGAVVIDDAEGIAKEVAGESAQKVDEDVVVIDDDEGAILIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URF3</accession>
    <name>A0A1Q5URF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URF3"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="299" mass="33304" checksum="C3D4D7582F47505C" modified="2017-04-12" version="1">MATILVTGATGKQGGAVVQNLVKKNAPFKILALTRNTQSASAQKLIKLSKNITLLQGDLDNPGEIFKKAPQIAGPIWGVFSVQASVGNKSAEDVQGKALIDEAIKNGVKHFVYTSVDRHGAKSIDNPTKMPHWIFKYHIERHLIEKTKNGQMDWTILRPTAFYDNLTPDFIGKVFATCFRMSLKGKSLQMVACSDIGAVAAEVFLNARDYKGRAISLAGDELTYDQFVRIFKEKTGRDIPTTFSFVGAGIMGMVKEFGYMFKWFYDEGYAADIEEVRKIHPGLKDFGTWLETESKFEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URQ5</accession>
    <name>A0A1Q5URQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URQ5"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="3">
        <location>
            <begin position="534"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="914" mass="102298" checksum="A865465A26AE0BC3" modified="2017-04-12" version="1">MKYPFPPTDRKGFDVAIICALQLEADAVESIFDRFWDEDGDRYGKAAGDKNAYRTGVIGNHNVVLAFMPGMGKVHAASVAISCYSSFQGIRLALIVGICGGVPQGTEDGIFLGDIVISDEILMYDFGKMYPGGFQRKETVARSAVDSEVLAFLRKLKSPKGRQSLLGRTNHHLTVLQTQSDDYHCPGRRLDQLFEPTYHHKHRGTSKCKKCKKGEPCKKAQESTCEELQCNPKKLKHRSRKNPSGINIHFGRIASGDMVMKSGVDRDRIAAEEDVIAFEMEGAGVCGSMPFIVIKGVCDYADSHKDKIWQKHTAGAAAACMRSLLEQWAAIDHAEQRRIHIKDLLDGEPEPSIKTPSEIQSTRGDEGYHSQNSYDSSDGEITQVLSRIESCFKSTLAYFKQYRKFLPRDIDLKRTFKTQRVIFAGNVKSLSSDAPDSVNDYLGSSKKVCLQAALEIERKLEHIQGLTKHLPAPTKAREQSKSATETLKHAVEDLKSLIQVFASSIPQTNQPLPWVEPNKAETTRSRREFQHFHIVQQAANSLYDALGTACNLHTIHDVHLSLQPDLDRTSTRVRFDVAFSQHSMPLGTAVWINVESTIKSVETSSDPGCTSTTTSMTPLKRQSSQKEQKPSSTMVRKTVQFHLQSGPALSLHPVQLTAAIPNLYLQRNFCTVVERSLHKRICNGCIGLLGDNESCKHLAYLGRQTESSTTPTSLSQLVSLSKANPMKEMGTYERVRLARYLATAVLYYHATPWLRKAWSSNDVYFFDNHDASLQQERQRIPYMTASIHASSSSTQSQSRLSDYHHIIRNPVLFGLGVMFLELAFQAPLGALQHPVDLEKGETWGFVEYFTAHRVVEQSHSKVSTSFKKIIKQCLHCDFGHDSDFTSPALQQAFHKDVIAVLEDLEEVFRDLQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URV1</accession>
    <name>A0A1Q5URV1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_1409</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URV1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012682700" evidence="9">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="418" mass="46297" checksum="829258845060FABB" modified="2017-04-12" version="1">MAGCVILSIGAALQCSAFSIPHLIVGRIIAGVGNGLNTSTIPVWHSELSKAASRGKGLAIELAINIFGVMLSYWVDYGFSYNTSEAQFRFPIALQIVFAILTFIGVVFLPESPRWLIKHGNEDKARHIIWSLQDNAREIDENDAVVSLDVQEISQAIRDEQAASTEGSFKLIFQNGQQRFFYRTLLGMGGQMMQQVSGINLITYYATVIFEESVGMDHNTALLLAGFNGVAYFFSSLIPIWVIDRLGRRKLMMFAVTGQGACMAILAGTVWDGGHAAGLVATVMLFLFNFFFAVGLLAIPWLLPAEYSPLAIRTRSAALATATNWIFTFLVVEITPVSISNIGYRTYIYFAVFNFCFLPLIYFFYPEARNLTLEQIDHLFTGEKVKLYWHPSMGMAGDADARIAQGKDLESVNAQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMT1</accession>
    <name>A0A1Q5SMT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="11442" checksum="F8F0836091FC06B3" modified="2017-04-12" version="1" fragment="single">MQDHPLLVPRIRPGFESRDPPNTLVPHGLYPTLTHFSDAITAIPREFCRHNALLKEVDAQAWVLEQNLLRLLKHSSESQPMPRPSHPAPIVRGRENIFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNG7</accession>
    <name>A0A1Q5SNG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Early growth response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_13617</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNG7"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO89551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="889" mass="99183" checksum="3A671AE0BC8ACD4E" modified="2017-04-12" version="1">MFDDSPPIVDPLNASQSPVKSKDGGYFQCGFCKRHYNRADHLIRHVRSHTREKPYVCDVCDKGFARPDLLKRHATGHAHDRDRKRKRSSSVAKQSRVSQACKACASSKLKCDEEKPCRRCRERSLHCDWQDVVQESSPEPQQQSSTENSHPIIPGQPLDLAASVAFSPMPTPMDDFSAGSRSGGILMTPHAPPPEPPVISPEVLQAGEQMPMEYGVSPTDQESGIFSVDGTFFPNFIPDSLISSLSRYNDPFEPSNLIPEFTHYGALEIPALDFNLTDGDFGLIDMYNSRSFIPGAHEPEPQDRFDADSGIGIGAEAYHRSSLSQWKPAQKDHAFDDHENLSVPQTIDSPEASATPDRQILCERLSSSSRDLIFGLVLEISREANLSRIMKSFPSTELLDGLIQQYFELQSHSVDSFIHGPTFRPNSEHASVLAALAAASAVRSPVPTIRKLGYALLEIVRLYMPIKYENDNSTTRDLRTSQTYALNIDIGIWSGNRRKTEIAESFSQPLVTMLRRALRFRRSVYTNIVPLADDTGEVLERKWHDWIEQESFKRLVYHLFLHDSQSSVTLNINPLISYADLELPLPAARPLWEAKTATEWKELFCVITPERMPSLADLLRDMSQLSTFQDRIDTQLSAFVLLHGLSSLINEYHRLKFISTSNSKHWHALVTNSRQQELDQALQHFRMVCSELRVQCRPEIVLVCEVVSMLLHMSLEELQLFAGKEDKQEARRVYHSALEWITSPDSRRAVWHAGQTIRAARRMAPNSLTGFLAIGVYYAGLALWSYAVVSKAKNTSLTGSPASSIASQGPTVFLDAEEMPEVTKFVTLSCGVPAIQGPGGPIALADTSTTMQMVQRVLRPDPSERTPPLVQSLAQLIGDLGHCVPAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNZ5</accession>
    <name>A0A1Q5SNZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNZ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="356" mass="40327" checksum="303EE16E0742B6F8" modified="2017-04-12" version="1">MGSTTETVTTAPSGRLFAHGTNVKYGDFRDDLLQNGFAVVKGAVPRERALSYADGIYEWLEGFGLGFKRDDPTTIHKDHLPDINEKGMCLGYAVSHESFTWGVRQEPKVIEAFEKVYGTQDLIVSFDSIGIGFPNRKDIQPNKPWPHQDQDPEKPGFRCLQGLVNLLPNGPKDGGLIVCKGAHLLSEEYHEEFKNEEDKIWSWTKEWYGFTEKGLKWLENKGCEWIKIEAEPGDLLLCKSCIPVISSLSREPTRFAGDSRTPHYNVSSETSQPRFCVYTCFMPVADATKEQLLIKKNAFEETKMTTHWPNAMHVVDLPVYRNGEADPYQRSSPREPVQLSDRGFKLTGIPYLEQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS71</accession>
    <name>A0A1Q5SS71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13131</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS71"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS71"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO90830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="21912" checksum="FB321DD236C9363B" modified="2017-04-12" version="1">MFIQRTASAIARRSPARAFTLAQRPFSSSIVRRNEKKWAVEKEGKILSFDEIKNEDDLIAPGAKPGTIPTDYIQATGLERLELIGKMQGVDIFDMRPLDASRKGTLENPIIVNGAGDEQYAGCTGFPADSHQVNWLTVSRERPIERCNECGNVVKLNYIGPEEDPHAHHDHGHGHPAPEEPKTFADYVKPDYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUG7</accession>
    <name>A0A1Q5SUG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUG7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="112" mass="11777" checksum="F74F170E2B42EA10" modified="2017-04-12" version="1">MFCGNAPSSWGDTPLMYACNNGHTKAAAEFLPYLTDPDSITKALFWSAGSGHAACVGLILQHATVDVNAKYMGETLLFKAGKCAGTAKRLAAMSVISTARLRSSIEPIPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUM6</accession>
    <name>A0A1Q5SUM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">54S ribosomal protein L12, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUM6"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO91606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="19867" checksum="1FD273B11ED050DD" modified="2017-04-12" version="1">MSFPIQAAARSCRQLSGSVRPSSLRIATTYTARTPSYRRWESTEAAAAPINPKIAQIVDQISTLTLLETADLVSSLKTRLNIPDLPVGGFAMAGGAGPGAAAPAAEEEEAAPAAAEKTLFNLKLESFEAASKPKVIKEVKNMLGLSLVDSKKFVESVPKIMKESVPKEEAEKIIETLKALGAKVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVM3</accession>
    <name>A0A1Q5SVM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Positive regulator of purine utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000743">
        <property type="protein sequence ID" value="OKO92077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SVM3"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO92077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="698" mass="78382" checksum="7C6AA6BEB113E8DE" modified="2017-04-12" version="1">MDTPRRSRNRAACRRCQRRKIRCNGELPSCGACIKANVPCVNDGKQEVNRTYIANLQRRVQWLESLVREQRTDVSLEGGPPLYSNEYANDETLGFEEGSQGAAAMTSPRQDQPLPIENTQQSRTQSRQAHEIGLVTLSSGGEARYIGPSSGYFLANLVFSSAGRRSRPPGNRSVDEPISLSAELFNTPAVLPSRREDAIELSSKYFSTVHLLYPFLHEPSHMSRLERMYTEESAAKPDPSNAFHVYMVLAIAASDLSRRFRLRLPAEGYYTAATQYFESACAEGSLESLQSQLLLMVYALHNPSCGVNIWGLNYQCLGALIDLGLQRDIRTSSSFRVSFLEQEMRTRIFWVVYSFDRTLGTMMGRPIGVRDEACELRLPSDVADRHLADAVAGERSHDTPSHITYSIHLFKLAKLNSEIKYVMHSICRDPPKYAYPPVPDIHHWQKDMIDRLKIWHAEIPRTANMASIAKLCETKYHEMMILVLRPSPGIPDPSEELLAQCFQHAVELLRGFGELYKQESLLYSRLVVHSIFLSTLIMLHCLWRLPQVTSQIQIDDLVADTGIGMNILSSIGEYWTEARRARDCIHELSGATVQRLLRLRTLEVSPRLSRAQPTASTARHTRSYSSNEAPGSALPEQVDSAIDIAPSTGSYPDSYDYSLDGSSCLNDAMPGGFMDFSGVPDFDSIIQQYLDPNAVVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXC0</accession>
    <name>A0A1Q5SXC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXC0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="253" mass="27938" checksum="99424F12373A9EF4" modified="2017-04-12" version="1">MSQWFPVSDLAKTLVKEHAREPTPPPSRLIGLASLDGTPGRLLDCLTKYSKAGLAAIKPSSSSNVSTPLRRFQRDFENKVRALPSVHGTLDAKCVATKIQDLGISLDTKFLSWGSSGFDLSLLKNWLPAEGFDNVLPAGQNLCLLLLEFRANVDRVLGRECFRGRSFPLGLPTLFRVVFGEDDPLVGKNHHAVVDAMQLSLLAIVFIDLCRPPKKRLYWDGKAVKGLRPPHKRQSSLEAPLSSTSLEKRARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXM8</accession>
    <name>A0A1Q5SXM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXM8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="218" mass="23286" checksum="F465C925E63A5549" modified="2017-04-12" version="1">MFATRSIGRQALRIPRWTQARFVSSLEGNPHIKQYVFPNQGSNNSHILSLLSSEPVNPDLAIGVTSQLPPTPDSLRENPKFLGILQEVFAKHAHEDPDAQSQAQVMVSTAGANLYTGGVLMPNQRNRRRTEAGDSSGGASGQGGAGGAGKGGWIHISDNRRPPEFGRIAWYGTDVVSEDKISANLCPGPRISLAVSRLMGMVNLLAATANTKVVVCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXY3</accession>
    <name>A0A1Q5SXY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXY3"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO92756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37322" checksum="7B13A2C45DC94AB4" modified="2017-04-12" version="1">MPFFFPRRHRHYKLTLWLMVVELPITVVILTLTGIASHNTYRTLLWQDGADNGFNSAPNAALYAAANYRPYTAPLVWSSFMTNYNLVIGVLSVFLLIVKFPVHCMHLFFPPLGAFTHGAILVLYIVSARYQAGSDMSDPKHPQPGPPWYITKSCSVAAHKSNIGYCEQAKALFAVSVVLIVLYFVEFVVVVHSCFITKEERDEVVEQREEKRIEKEFEEEIMKSPSMIPMTPGFVGQDHALMIPRTPGYPPMAATSPVTHGGILHAPFTPRTPGRTPGFNRLGGGGGSPSTTSDLPLRDHSAMPSPQIQSLPAQTTEPQTGPGSAMYFPPPPKKASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ16</accession>
    <name>A0A1Q5SZ16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ16"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012411785" evidence="2">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="8046" checksum="D20180BD92EBDDF7" modified="2017-04-12" version="1">MNLINIAAALALASTVCGAIIPEGALGSTIGSVSKIEHTVASLPVITMDKLHGTVSENTSAEDADTAAADDTTTEVYDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0F6</accession>
    <name>A0A1Q5T0F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0F6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0F6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="363" mass="40719" checksum="61117A25569CB7F3" modified="2017-04-12" version="1">MALPISSPSPKVGRFQQAMESVYGNFSDITEPESWTPPPGSGGHRGRYLWTDAFGVVNLLTMHKEYLRVGDKSCQDDRYLVMARRLIETVHNVLGRTRDGRSRLPGATDQNPLGGGLRIGKTSDTGPDCDGQYHHYLTVWMFALNRMAIASGDMKYNRLAVQLARAIHPKFFVDRKAARPHMIWKMSMDLSRPLVNSEGNLDPIDGFVTFRLLQATAAAAGDGDVLEEEISDYRRVMDRKGPHFVSKDPLDLGMTLWTAHWFSETESWASTLVTRYFERSIKFRLAFREFGTCMGLQCESEQTGEKERAVDFKSWSDAIIVAWDPYMELSASVALTPADLRPITRVMYASALIPGGPMPSIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0U2</accession>
    <name>A0A1Q5T0U2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_12143</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0U2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0U2"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 18" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="17">
        <location>
            <begin position="473"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="225"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO93864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="995" mass="109411" checksum="379EACC88BB89DEE" modified="2017-04-12" version="1">MHRRVVWRLSRRVDLSTSTTLSSPILPSSRTFRSSASRLNSENGAGDGNSDGAAPSAPSPAPKFGNRWGARQASKPTGLSPAEQALRDAIMARSKPPPPPPEAPKGPDPEKRIPGTQFYVNSQGKQAFARSANHPVDHQHLHNRVARHLRGSSRTENRPSRGNREWTCQSCNKVVFAKHKVCPFCQTARQDAPRPPRQEQQPKKKDWDCPDCGHFNFARRDACTSCGNPRPDAQPSETSTSRRESTRTGKLHSLGQSILAEAGEENSSSAWGSRKTQNDRTSRHGAPTRISQSEGRESRGQDETKKDRKVEEKNEKEKELDKKDQWSWDMSALDQLQSMEAPPTPVDVQKKPKKRDGRKDRGSSEEGDFDPEDRKRRRDKRQKKAKEEVTATPLHLPEFISVSNLADVIGVRQAEFVARMEDMGFEDVTYNHVLDAETAGLVAAEFNYEAIFDTGADDIEAAPVPEDASDLPPRPPVVTIMGHVDHGKTTILDWLRKSSVAATEHGGITQHIGAFSVAMPSGKTITFLDTPGHSAFLEMRKRGADVTDIVVLVVAADDSVKPQTIEAIKHATQANVPIIVAISKIDKEGRNPERVKQDLSVHGVHVEDYGGDVQAIGVSGKTGEGMIELEEAIGVLSEMQDHRADTACNAEGWVIEATTKSYGRVASALIRRGTLRPGDVIVAGQTWARVRTLRNEAGLSIDEATPGMPVEIDGWRDQPVAGTEILQAPTEQKAKDVVAYRQDRADTQKLGEDMVAINEARRELLEKRRQEDQDSDDAASAPVEASGPKAINFIIKADVDGSAEAVLNSIAAVGNNEVYANILRSGVGPVTEFDIEHAASAKGKIISFNMPIDPNMSRLAEQESVTIMDHNIIYKLIDDVKDVLSEHLAPTVTQRVTGEAEVGQIFEITVKGRDKTSIAGCRVRNGLVNKTKKVRVIRGNQTVYDGTMTSLKNVKKDVTEMRKDTECGIAFDGWTDFAVGDHIQCYEEIFEKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T113</accession>
    <name>A0A1Q5T113_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T113"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T113"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="37"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="404" mass="44325" checksum="4A11098344C1FA31" modified="2017-04-12" version="1">MFVVRGSSAFGLCRHSAAAARWPAHRSYATRSFDPLRILFCGSDDFSIASLKALYDYRLKNPDQISSIDVVCRPGKRVGRGLKKIREKIQTVPIKEAASALSLPVHEIDTFRGWTPPETPNGPINLIIAVSFGLFVPPRILNAAKYGGLNVHPSLLPDFRGPAPLHHTLLAGRTKTGVTLQTLHHKSFDHGKILAQSPAPGFDIPNPESCTVPELTSLVSVKGAQLLFDGIQNGLFVPPVQDAGWLSEKDTQNLIHAAKIMPEDRHVDWANWDLVNFNRRNRVLGNLWSKALVASKPGDGPISFQQKRVILTDVEEVDPPKGSEAFAILPGLPFTNAPHPVEPKKNRALYVFTKDGKALRINHLKVEGEPVAEGLRAAIKARMFGDRSIQSGGAEFTPFRNPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T221</accession>
    <name>A0A1Q5T221_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T221"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="658"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1811"/>
            <end position="1889"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="658"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="815"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO94309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2256" mass="246510" checksum="8BBE5669DA024616" modified="2017-04-12" version="1">MPSAESQSQLIRDTYMRCGLDPVRDRPHYFEAHGTGTPAGDPIEARAIHDTFFPAERGPDDGHLYVGSIKTVIGHTEGTAGLAGVLKASLAVQNGQIPGNLHFQELNPKIRPFSKNLCVPTALTPWPTLSYGEPRRVSVNSFGFGGTNAHAIIESWDGAYDRYTSKPDAGGLVVLSANSAQALAAKATALAGYLREHPNTDLVRLARTLFQRAEFLFRASFSATSAAQLAEKLESRAEALKKTARIPAIPKTLPPRILGVFTGQGAQWATMGRELYEASSVFRKAIDRMQQSLNALPDSDRPEWTLIDELSAPKETSRVGIAVISQPICTALQIALVDVLHAAGVDFAAVVGHSSGEIAAAYAAGYLDSRDAIRVAYYRGFHSVLAQGSDGKRGKMMAVGMGLESALAFCDQFGANLRVAASNSPTSCTLAGDAVLIDEAKEQLDQDKIFARVLAVDTAYHSHHMLPCAEPYLNSLRQCGVKALKGPRKCEWYSSVWGPNGRSRSFDSEQSMKLLEGQYWVDNLTSTVQFSQAVNRALSEESSVLDLALEVGPHPALKGPTSEVIKSLTGLNLPYCGALNRGQGAVEAFADSLGLLWTSFPSSRPLITFDGMQRALPLTSPKKPSILKGLPTYPWDHDSLVWRESRASRLFRNGQPQHELLGRPTTLGEDGRREIHWRHVFKLNELPWVSGHTIQGQVLFPATGYVTMAYEAAVRLVDDQQTLCLVELHDIEIVRTMGMLEDSSGLEVLFTIRVTSQTDSCITAEVACYSGDVDGTKLDGPVNALTAHFSGGVRLFLGPSQKDALSSRNKPLLPLNALDMEQFYSYLSKVGYNYSGAFRASSVERHLNHAVVSVPNPPESSSVRPSVHPAVLDTTIQGILAAFSYPEDGRLGAVYLPTGIDCVRINMTAASPDFLMADSRLTSSGEKGLTGDVDLFNASDETVQVQMRGVQWTPLNQSRERRLYASETWVRDAAYGIEPSLKTKFSPEDEVLRKLLVRTAHFYLRKLRSQIKPAELLVMGKHRRHMMKWVRDHLFPQIEAGKVPDIEPEWENDTLEDVQKWSAPYIEARNNDMLILHAVGKNLAAIARGIMPALQVLLKDDMLDRLYVEGVGFADGNLDLGPLVKQLSHRYPRMKVLEVGAGTGGTTRAVLSAVGDQYASYMYTDISAGFFEPAKEKFSQHAAKMSFKLLNIEKDPLDQGFDEGAYDMVIASNALHATRSLKETVSNCRRLLRPGGYLVLLEITTNHLPIQLIMGTLPGWFLGVDEGRVWVPTLSLDEWDSLLKDTGFSGVDTSSTPSFCSVIISQATDEIFQELREPLSVASRAAGRSLGHVLVVSDVASELASKSQALLASTEGVLQCELEGLEENNCPVGAAVLCLCDLDSPVFGEMTVARFEAMQALFRNASAVLWVTSGAASGKNPLANVTVGLGRTLLAELSDLRLQFLDVDEPTSLEPSLLATLLLRLTGMNQPDPSEILWTHEPHLALRDGALYIPRVLPLDSINSQHTAKNSQVTQLTDPKGMFAADKTYILFGMTGDLGISIALWMVDNGARNVVLTSRHPRVPAGVFQLMSQKGAVLRVVPVDITNKEGLRAAYTEIKSSMPPFGGIINGAMVLRDRPFLDTSWEDFEAVLAPKVAGTRNLDELFGGDEALDFFIGLSSATSIVGNVGQSAYSAANHYMASLVRRRRERGLAGSVVVIGLLTGLGYIYRADRKRNAAIEKSLLPQLDRQGETDLHDMLAKGIECGRPDSDLPSELITGVRKIFTEPWHEDPRLSCYLLQEGAQEEDTGQKQADGNIKVEAQLATTEDPKESLAILVKCFTQSLGSMLQLDPAQISDDVPVADHGVDSLVSVRIREWFLKELGVDVPVLKLMSTNHTLSRVCEDALVGWRNLRTGSQAESQTTTNSHDDPEMDWKKEVADLIDGIPSLIPAGADLVKDVPRSSSRRVVLTGCTGFLGTNILRNLVADGDIAEVHCLCLRSRPLRVKDAKIHEYKGDLVKPLLGLSTNDFKHLCQTADMIIHVGADVAHLKSYEMMRAANVVSTQYLLAMATPRRVPVHFVSSSSVAMLQKDTSELAEVPPSSFWPPSDADSLLKNAIGYAASKWMGEILLERAEGLPAVVHRFPNIMGPDAPEEIPLVALDKYCTKMRAVPALDPKQWQGELDIIDVSDVVPELLAKAYAHDPREPFAVHNYCSENRYVLSDLEGMYNDRLGTKVKVLSVREWMQKAKALGMPAGVEATWTGNEVFVSPVLRKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T249</accession>
    <name>A0A1Q5T249_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_11577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T249"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T249"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="13"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="33908" checksum="8BC4FA6AD6B11B6E" modified="2017-04-12" version="1">MGSLPEPNAIPLREPIAVVGSSCRFPGGANSPSKLWELLKDPKDLVREIPPSRFDTKAFYNQNSQHHGSTNTKYAYLLQEEPRLFDRDFFNISPKEVEAMDPQQRCLLETVYEGVESAGYSIPQLQGSSTGVFVGATCFDYQFLSMRGFDSLPQYYATGGSMAILANRLSYFFDWRGPSVACDTACSSSLVALHQAVLSLRSGEIGMAVATGANLILGPELFIAYSNSKLTIAYKLNMLSPNGRSYMWDSSADGYTRGEGFASVILKTLSQAIADGDHIECIIRETGVNSDGRTPGLFAKLSLMSTVITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T289</accession>
    <name>A0A1Q5T289_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T289"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T289"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="397" mass="42236" checksum="263B7078188BBB97" modified="2017-04-12" version="1">MGSTENGHSTHRFGTLAVHAGAPHDPATGAVIESISLSTTFAQTSVGNPVGLYEYTRSANPNRDNFEQAVAALEHAKYALAFSSGSAATANILQSLAAGSHVVSVSDVYGGTHRYFTKVAAAHGVHVTFTPTIELHIEDLIRPNETKLIWIETPSNPTLGLVDIAAVVDIARRHGILVVVDNTFMSPYVQNPLDHGADIVVHSVTKYINGHSDVCMGVAAFNSEALKERLSFLQNAIGAVPSPFDCWLAHRGLKTLHLRAREATTNATAVALALEASPHVISVNYPGIDSHPHRKIALKQHRNGMGGGMLSFRIKGGQTAAHNFCKYTKVFTLAESLGGVESLCEVPSSMTHAGIPKDQREAAGVFDDLVRVSCGVEDVEDLTADVLQALELAIASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T298</accession>
    <name>A0A1Q5T298_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T298"/>
    <dbReference type="OrthoDB" id="10612255at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="271" mass="30268" checksum="566BC6DB92DA87EA" modified="2017-04-12" version="1">MDSELKKTLQPKVIQHSAVQQMPVHHTEVHHSGVQHDAVPHDAITHAGVHHAVDQHAAEGYKSNQQLKCTRSQRDMKQATGPRIQYRSVTWRNMSDKVTFLERKCESLQDRVAALELNAQHSRDVPLPSYETEDTISEFESCFEFINPENENDNDKDQSGRHHANSCSGKDRSASSHKEQGLPDSFKKRLCKNDTIVIEIKARIAKLLGDIDDVVREMKETHEDINSKLLQDTDLAVRSQQGLSGQPSAPGVARAGAYGKFEGPAGVVDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T3X8</accession>
    <name>A0A1Q5T3X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thymus-specific serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T3X8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T3X8"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000196">
        <property type="entry name" value="Endoprotease endo-Pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000165">
        <property type="entry name" value="Serine peptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012118056" description="Thymus-specific serine protease" evidence="6">
        <location>
            <begin position="20"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57555" checksum="8C6CE5DBB3B1A5BD" modified="2017-04-12" version="1">MHFSIRVALPALCASVAQAAIAPKPVPPPSTAASTASSGQSTFQQLIDHKNPSLGTFPQRYWWNSAWWDGEGSPVVLFTPGEEAADQYTGYLTNRTITGLYAQEVKGAVVMIEHRYWGDSSPYLELTTENLQQLTLENSIADLTYFAKNVKLPFDTNSSSNAQNAPWVLSGGSYSGALAAWTESTSPGTFWAYHASSAPVEAISDYWQYFTPVQEGMPKNCSRDVSRVVDYIDKVNKSGSKKQVQQLKELFGLGDIEHFDDFASALENGPWLWQSNTFYTGYSGFYKFCDYVENVENGTSKLPGAGGVGLQKALQGYARWFKKVYFPGSCANYGYWSDPSTTACFNTYNASSPIFTDVSVNNTVDRQWQWFLCNEPLFYWQDGAPSGVDSLVSRTVNAEYWQRQCSLYFPEVNGFTFGSAKGKTEAQVNSWTKGWSLTDTTRLIWANGQFDPWRSSGVSSSFRPGGPLASRDSAPVNVISGGFHCSDLIVKNGAANEGVQKIIDAEVAQIKTWVEEYYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4E4</accession>
    <name>A0A1Q5T4E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4E4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4E4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="222" mass="25007" checksum="45028C02CEF68B27" modified="2017-04-12" version="1">MDALISRLDALVLNPDLAPFLSLLKGARNGVVYGSKVRFPHALVMIFLFRSGTFREKVKLVFKATRQHARNLATFAIIYKASMIILRNISPAGSGKEGRYDSFFAGLLGGYAVFGRQRGSISQQIVIYVFARVMLSLAKLSVEPNMHPLSSLITPESRAQITNNAWPAFASLSWAFVMYLFRWYPETLASSLRSSMVYMCVTLIIPSPLRQIWPCFYPDHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T621</accession>
    <name>A0A1Q5T621_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11192</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3 7">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T621"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T621"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="30370" checksum="036C2B6429DA7A3A" modified="2017-04-12" version="1">MGKINLTALRVRKTALNQFASGKINRLPQWVDVVGEIPPSETLIRNPPPQHQLVRQRMKTVAGSSKPQVVFEVQEKRRKSKKPSRLFQPLELKYEEDELRQDFFRDHPWELARPRVLLESTGKDHENYDWSRIKQPGKRLDGESVVQRQLWLLNNVPDMTKTNAYDIARREFYRLRLQEDIQRRVAAEEAEATGANFGLSYLEIGMDLENQQYEKWKAWARTEAQLFEQRTAALSGAPEIALEQQSQKEEAFTEQPDAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8P1</accession>
    <name>A0A1Q5T8P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10769</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8P1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8P1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="123"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="379"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO96594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="434" mass="49056" checksum="8633E75187E53250" modified="2017-04-12" version="1">MPSLGGLLKKRRTKDSQTLASELPAPSENHSQTVPDSHDSHDSSEGASMQPAGSSQVSPQQSNNAASINNLIHNPANASQGHSSAHSPNGSQAQGQQAQQQPQQQQQPRQERTTKGKYSQEDFLLQRTLGTGSFGRVHLVQSKHNHRFYAMKVLKKAQVVKMKQIEHTNDERRMLNRVRHPFLVTLWGTWQDSRNLYMVMDFVEGGELFSLLRKSQRFPNPVAKFYAAEVTLALEYLHSHQIIYRDLKPENLLLDRHGHLKITDFGFAKDVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGFTPFWDSGSPVKIYENILRGKVKYPPYLHDDAVDLLSQLITADLTKRLGNLHGGPEDVKNHAWFAEVTWDRLARKDIDAPYIPPIRGGQGDASQYDKYPEETEHYGIEGEDAYGHLFPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8R4</accession>
    <name>A0A1Q5T8R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_10770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8R4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8R4"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO96595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11149" checksum="C6A1FA03E637229D" modified="2017-04-12" version="1">MSFLGSSSSPKSNEDIKTALLQQVQQEQAMNNARALIGKINENCFDACVPAPGSSLSSKETACMSSCMDKYINMWNTVSRTYMHRMNEERKKMGGDVSGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V5</accession>
    <name>A0A1Q5T8V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AB hydrolase superfamily protein C4A8.06c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8V5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="570"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="736"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="883"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="985" mass="108163" checksum="2859974F68079942" modified="2017-04-12" version="1">MTSGLGLPFPVDVRQAYKPDRLSHLNPFPPFITSVGEWRSHAIAYGRVGCGLDPYRPPHSNQSCGSTIDAEDELYEVHRCMKLTCLQYRHRKARHNHPTVHLTYDEGIQVVRQFLYYASKHPVEDIQAFTRQSVPSPHWVRTESITIPPEFLLSAADVLAKQLGPKGLVRVGGEKWWQWRGPAEELKGEWVEMRNHYNEMKKSNSRNNRIMLYIHGGAYFFGSVDTHRYMLQRHARKLKGRVFAPDYRLAPQFPFPCGLQDCMAAYLWLLQSYDPKEILLAGDSAGGGMALSLLVMMRDQGIPLPAGAILISPWVDLTHSFPSIVEDNPGDYIPPYGFRYKPSAAWPPPNADEILKIKNLSRKETFTARDIEGAGPTANKDARDTAVRGYTLHENKNPAEGHAYPGMQHTADPGTLHAEPDNIHVVLEGKTVELKDQIQMYATNQLLSHPLVSPILQPSLGGLPPLQVISGGGETLRDEQFYVAHKAANPAAYPPADVYLDEFDPDREQLNKYEPTYVQLQVWDDLCHVAPTLSFTRPAKHMFRSISQFGSWALARAQKTEVEIMDDNLVSPISSSDSDSSNSPNSPGGIGSKRKPTFPAGLSVGKAGDPLPAFEQHMIRQRVDKRGRMYHLDPPSSYPALAIPPAKVGAVNPELIRKWLEAKHEWDQKFSKEKLCVQSRRIKEMAHGFQDFEGECPPPSSLAARRGAPGVLPKWRAKKNYGLMLWSGWGSKHDERTMEKASEAEKFGQTTTRRSVDAGQAGSYSSAPLKNPLAGNTGESRSETAAGSSSTGGTPAITWDTTKEQRQWNGETDPGRPSESTSLRPTSERSGGPILILPGVDNRKFNDENASTRALFHAAGTLPMSSDASLPYLKGRPSSVGGSVAGRSEFMSDNGEDASTVGGDRELSAVPGVANDAASTRAVLSAKGVVGVVSSRDSGQISTDTASLRANISDADAVSAAGKTSTSHRPDMPEREVFKTAQEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB36</accession>
    <name>A0A1Q5TB36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB36"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="52" mass="6127" checksum="523048E233953050" modified="2017-04-12" version="1">MHSIGAYQYVSTYDGTIFEGNSYTIFQRFDFDTFAVRMYLGFILDIVEKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBA7</accession>
    <name>A0A1Q5TBA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBA7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8374" checksum="E5F2362E7DD7AE49" modified="2017-04-12" version="1">MSVTPEIITFASRDTIRLRAFEVGVNWVTQVARAMAADPAKGNPVGPERSCRLGPAQVERQINEEIYEVKQVLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC16</accession>
    <name>A0A1Q5TC16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC16"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="12">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO97762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115149" checksum="11A5F33B35DE29AA" modified="2017-04-12" version="1">MKAWFEVITTPTADTPGTVVGLHFPDKRYLFGQLAEGTQRACTERSHKLASIGDIFITGRTEWANMGGMIGVILTQADALKSSNDALEEGNKKKAERKAAGTQAKNKAKQSSSAEEPRKINVTVHGATNLMHTMATARRFVFRTGMPIYMKEYDSASISKQIRTDKEDPFEVPTFIDTNIKVWALPLKPTGASQVVRSHSPRKRSLDEFQETDEQLDQNAQNQMLRQSIVSDMFDSDWKMDALIETPLAEVKMPAALFVRNVDTKDIEPYKGPIPGDEKELPDIKVLVRKPWPGATITSLPPTTPSKEAVSYVIRSHDIRGKFDAKKAKDLGVSEGPDFARLARGEAVQASDGSTVTPNMVLGAVRRGKGLAVIDLPSPEYVEDLVNRPEWNSPSVTTELKVFIWILGPGVGDHPKLREFVARFPDAKHTVSGVDYCPNYLAFNSAAGAAVRLARLRGDNYPIPVHDNVTVPQAQTGSQPGSISLEESPFEALQPGLVIDMEPQFGFNKSDAITPLNTAKTLFQIPRSVEKRMEVIRTRVKKPYFQHQLAEMRKGLPGADVEITALGTGSSSPSKYRNVSATLLHVPGYGYYLLDCGENTLGQINRVFGYEKTREILQNLRMIWISHLHADHHLGTASLIRAWYQENYGSDSKPIEPESDITKILQEKRLAVVSDEMMIAWLEEYAAVEDFGFDKLIPLCAHPDPAGPSIITRFSLRQSRNGNSPYGMASGGRTVLNFKDDSSPLTPLLKSALGVDDILTTRVKHCKGALAVSIVFPDGFKVSYSGDCRPSDKFASIGQGSTLLIHEATFQNDMIGSALAKRHSTAAEALEVARRMGARSIFLTHFSQRYQKIAAIDQNAGTNRHNDVDMCDIAAKETTDPDIPLDEPEEQPSTLKSAAHLLDDIHFPLPDRPGLPRSDYIPGINAPFSAAMDYMRVKVGDLALAQAYAPAVEKLVELLERDAYVQSEITKKAIREAEEVRKAKKNKKFAGKKGVAAVGAAAAAAVAAEVEEVEEKKKKPEFELPEHSVWSASESEAGWETSDFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC91</accession>
    <name>A0A1Q5TC91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO97837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="463" mass="50465" checksum="50151EEB00A3C5B0" modified="2017-04-12" version="1">MLSFLKDIWCLAWNRQNSCSVFPFIGAKMHSIKSAASTVAYDLVTFYTGNNTGDVPGNLPDPYYWWEAGAFFGALINYWAFTGDSTYNTITVQAMEHQAGTKGDFMPLNQTYTEGNDDQSFWAMSAMMATERNFTNPTNSPGWLAMVQAVFNEQAHRWDKESCDGGLRWQIYTWNAGYGYKNTISNGCFFDIAARLARYTGNATYAEWANKVWNWSKVNGLITADYQIYDGTTVDSNCSSYDRTRWSYTAGIYLHGAAVMYNYTSSLSSNSSSNSSTVWKNRVDGLLTATNHFYSTANSSANVMEEPPCESTGSCDTDQLSFKAYLSRWLADVMQLAPYTYDTIIAKVRATATAAVSQCQGGSSGTYCGHKWSSGSYDGTTGVGQQMGVLEVLHGLLATEITGPVTANTGGTSEGNAAAGTESDETEDEILFSTITTADKAGAAVLTAVVVGLIFSAVYVMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD13</accession>
    <name>A0A1Q5TD13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor-interacting serine/threonine-protein kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000678">
        <property type="protein sequence ID" value="OKO98115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="392" mass="42919" checksum="B3DDAACA8E23FF03" modified="2017-04-12" version="1">MLLHHSKVHPSQPRLVDMNARDNPLCLAVDAGLKEIAQALINYGADLHVTDRYGQPLLHQAASNGHDDVIQLLLSHGVDVNSTDPGGHTALHFAAFHGHKSTTKLLLSTPGIDIAASDGEGATALCAAARGNHRSVALQILAEEPANVNARCLGQKTALHFAGWTALSYAAGQGDLRMLELLLTRTDLDLNVSRASPIYLAAERGHLEVVRRLVSFEEVDINQTVWHKSPLFIAIENGYRGVAKLLLEQGSRLDVNAKTSLGDTALHMAVSYGNLDIVELLLKDDRLDVTGINRYGESALELAARNGKEHVVRRLCRDRRARNVRHFRSAMEAASNIRILYFLQGQLMRHGVEHGVRRSDRLARGSSQLAESSTSPSLRRSTRMSQSYLNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD56</accession>
    <name>A0A1Q5TD56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrosine-protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD56"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF73">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="144"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="254" mass="27868" checksum="4234B4772A6E58A2" modified="2017-04-12" version="1">MINSDDIHDLLNTGLITPIPDSTVSKIISLPPFISVPGVSNFRDLSYENNLRPGYVYRSANLSDITEEGKVMFAVDLGITTIFDLRNEGERAKAPPPQIEGIDMIWMPYGARPASLNLRDFAGEDKGANGFVKMYMGILEACVPVFTQVFKHIRDQPDDPFVFHCSAGKDRTGVLAALILLLMGRSQDEIINDYILTRAGLENVRENLAQALALDEGTDHLSPEAIGMLELSGVRAQAMAAFLKTFHSTYYGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDN7</accession>
    <name>A0A1Q5TDN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDN7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="140" mass="15543" checksum="A4BF0B4854456B97" modified="2017-04-12" version="1">MFQGACQYVLLQASKAIFDLDGETDVDGIDLIRKTWGEVRTNTGPLTGENVFYGIGCDLLLELWPCGGLWIPRPNISDFSQSFIVVSGAGRVFRPIKDLHGRMNEAIDGLVPRETVVKGIIGGELFFERRIEKQTQELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDR9</accession>
    <name>A0A1Q5TDR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDR9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO98349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="147" mass="16160" checksum="D78A6BB7F52C15C5" modified="2017-04-12" version="1">MSYPDQRSEDQWRAVLSPEQFRVLREKGTERPGTGEYDSHYPSKGVYTCAGCDAPLYTADHKFKSGCGWPAYFDSIPGAVKRHVDNTLGMKRTEIVCNNCGGHLGHVFEGEGFPTPTDERHCVNSVSLRFTEDIGAAAKGSNETAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEC1</accession>
    <name>A0A1Q5TEC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEC1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="14750" checksum="1DBC30C36829DD89" modified="2017-04-12" version="1">MSKSHADEKSRIILTDSPAAIQKKIKVALTDSQPNITYDPAQRPGVSNLIEMLSHFEGQSCQEIAAEFEGASLRALKEHVASRIIHHLTDIRERYVSIMDDKTGYLDSIAQQGAETAQANAAVTMRKVRDAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFC1</accession>
    <name>A0A1Q5TFC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_8809</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFC1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO98892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="547" mass="61580" checksum="A89C64E506BBAA81" modified="2017-04-12" version="1">MKNRREQGSKADATVEVAATPAQPEHTLEEYERLFGVDEEAYEQPTTTRKELWSYYLYYNGDNGVGPGSYSQALFQWALNGAGYQPDTEPPLPCTSSSACVVPWAGGTRSVSSVILIANGLCFTFMTVIFVWLGSAADYGSFSRWLLLGLTVVCWALQYGMMAIRDPSQWPAAMGMYVVAYICYGATLVFYAAVFPRLARYMPHVRKAREEDLREGKIDQKEYDAIESLERNHISNIGYLLTLVLNLSVLLPMQSNQFSNNLALCLTNSYWVILGIWWFLFQQKRPGPKIPKGSSYATIGFKQIWLAIREIRSLPQTFLYFFAYFLLADGLNTTGTLVSIIQNDQVSFSFLQITYLGITQAACSIASTFGFWYIQKYFKFKTKNMFLFTNFFTVLIPFWGMLGLWTNRIGYHHTYAQTMISELMPRGYDNMFFALFGITNRASSIIGPNVIQAIINDSRNNWMGFPFLFAICAAAMIAICFVDVEKGREDGRKFTERRKVDRVVAETGLSADAIVKGKGVMDNGEMGSDINGNGHSSTEPVERGELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFK1</accession>
    <name>A0A1Q5TFK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFK1"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010206699" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="37843" checksum="FF45F721861214DD" modified="2017-04-12" version="1">MKFISVLSAISAILSCTAIVSAQSSPDPIGTIYDGRVPNDLYGSNYTYPWPVKLFKFYNQRQKLTMAFMDVPAGKNANGKTAVLLHGGNFCGVTWSDTARQLSAAGYRVILPDDIGFCKSSKPQGYSYNVNQQALNINSLLTALGIEKATVIGHSMGGMIAARYGLMYPSAVDQLVLVDPLGLEDWVAKGVPFLPIDQTYASQVVQNFASLKAYELASYFHNATWKPEYDTWVQMLANIYAGDYGSQYAYVMALVTDALLSQPIIYQLPNLQTRTYLMVGQNDITALGKAWSSATVAAKLGHYDVLGPAAAAMIPNCTFHMFPGLGHAPFLQDPQAFYEVLFSWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG03</accession>
    <name>A0A1Q5TG03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG03"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG03"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71079" checksum="1A82B6FC7F0E1D52" modified="2017-04-12" version="1">MSTWGWHNFSLPTTAGQTSPDDFTGLDWWTHGRLVNYDMPNNAENDISNWLIKNPQRLNLARTGVSFGDVNVTEADLQHKSQELDLWSGIINSSFVYNNTSVSVETVADPVTDTVGISVESKLFQDSLGIFFDFPYSDLNKFDAPFVGVWNATSKHSTKLTKINSYSAEIKHTLDENSYYVTINWETPGAISGPTDGTHRYHFQSTSSRVRMTVSFSLEPSKQSKDLKFSDLKRQSESWWQSYWCKGAFVDLSAAATVNSSAAELQRRTILSQYLVAVNEASSNPPQESGLVNNGWYGKFHLEMTLWHLAQFARWNHFDLLERSVPSIYERLLPSSIVRAKDQGYSGARWGKMTDPTGRSAPGEINALLIWQQPHPMYFAELEHRAFPGKATLAKWDAILTASADFMASFAWWNTSTAVYDLGPPMYPVSENTSPNVTVNPTFELAYWRFGLDIAVRWKERQGQSAPKLWIQVLENLAPLPIVEDAYAVYEGIPNMWTSNDTTNDHPAMTGIYGLLPPPLTGSPINLTIARNTADKVKELWALEDSYGWDFSMLALNSLRLGDVEQAVAYLLDPRFQFDDAGYPEGGRRVPTPYMPDAASLLLTMAMMAGGWDGAAGAHFPKDWPVEVDGFSPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH44</accession>
    <name>A0A1Q5TH44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TH44"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="54" mass="6137" checksum="6CCFAE5738FC8D39" modified="2017-04-12" version="1">MDEYTPDALVNRDDPVPMIDIKKPRRQRSGSTDSAHSRSSTQSKSSIQDRLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIB3</accession>
    <name>A0A1Q5TIB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_8179</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TIB3"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18002">
        <property type="entry name" value="DEXQc_INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001269">
        <property type="entry name" value="SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031047">
        <property type="entry name" value="DEXQc_INO80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="20">
        <location>
            <begin position="561"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="816"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1393"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="383"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1610"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="631"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1623"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1647"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1665"/>
            <end position="1674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO99962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1680" mass="188859" checksum="2338BE043FB2E6F7" modified="2017-04-12" version="1">MTGAPPYNAQSPTQQHRFAAYESPTKNRPFFPNNDQPQGQPQQQQFSQHPPQTPPAFGPSSVPRSPHFSHASSPLPSTLPPPLNGTAPPPHSSHSETSSQYPGPSGSANPGLPLPRPFSSSVMSGNGTSPYGPSTPHGHPSSRPDSHSQSPTRESKSPYRVRGNGVGYGPSAPKAASPPRESKPTRAADPMSFASILSGPTEEQPARKSTPPPAAATPQPPIRAKSDSRPPEAGPVPGTFQHKSDKGPVAEKPHPEPPKGIFTPNGLSKPAPELASVAARAPQRKPFPPGVDAEQVNRAMLDIDNGEKSDVEGPGFEEDMQLYMEKGRKRLMESYRTEQASRKRRRNNILNELARSFEKHAILGGERFRINNESSVIAEVQQKEIQDEKERKKDMQRKRRRENTVRLEMQKKLEAERKADKAQDSAEKAKFLREAERAQKKIRSTKRALEGGSAQDELGEVTPLAPNLEGGTTSSFHIGRGSPSRRKSGRAGPITRPKKSKEQKQAEKDAAENAYLAGLDDESIYLTPRDTTKKDGKSKEGTPILHLHYDSKGYNQIYEQIWRDIARKDIPKVYRIKTTSLSTRQENLRKTAQLASKQSRKWQERTNKSTKDTQARAKRTMREMMSFWKRNEREERDLRRLAEKQELESAKKAEAEREANRQKRKLNFLISQTELYSHFIGRKIKTAEAEAIGDGNVAGSNETIQPGKAAHTANLPDSVPNPNAKVTNFEDLDFDAEDESVLQQAAMANAQNAVQQAQDRARAFNQQGGEDQMAAFDEGEMNFQNPTSLGDIEISQPTMLTAKLKEYQLKGLNWLVNLYEQGINGILADEMGLGKTIQSISVMAYLAEFHNIWGPFLVIAPASTLHNWQQEIAKFVPNLKVLPYWGNAKDRKILRKFWDRKHITYTRDSEFHVLVTSYQLVVLDAQYFQKVKWQYMILDEAQAIKSSQSSRWKNLLGFSCRNRLLLTGTPIQNNMQELWALLHFIMPTLFDSHDEFSEWFSKDIESHAQSNTKLNEDQLKRLHMILKPFMLRRVKKHVQQELGDKVEKDIFCDLTYRQRALYANLRNRVSIIDLIEKAAVGDDSDSTTLMNLVMQFRKVCNHPDLFERAETRSPFSVGAFAECASFVREGYFVDFKYSTRNRIEYQLPRLLCSPEARVDVAGPGNDRAGFRGKYLSNLMNIWNTENIHESSRENGAFSFLRFVDTSAGEASEYSRLGVYERATLRSDKPNRLSRLNVVYGDKENESDGKSVWAQSMLNIVERNNRAALNEITPEGRMRNLMNVSRSAFEDQGLNLIEPCASPAASAPPITLSCSGQEATRETQRTLFNPVVRSTLYGNRTRQVEEQILLHKVDPTPYSKAPMLPGPMSLKSRYTHIEVPSMRRFVTDSGKLAKLDQLLRELKPGGHRVLLYFQMTRMIDLMEEYLTYRNYKYCRLDGSTKLEDRRDTVADFQSNPEIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLITRGTIEERIRKRALQKEEVQRVVISGGAAGGVDFNTRARENRTKDIAMWLADDDEAELIEQKEKEALERGEAFGATKGGKKATQKRKRELTMDDMYHEGEGNFDDASAKPSGTATPMSDNLDTPPTATSVTPAKRGRGRGGGKAGSSKRAKTMKERLRLIDGDGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIK2</accession>
    <name>A0A1Q5TIK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Secreted beta-glucosidase sun1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIK2"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP00058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="435" mass="44971" checksum="F65757ED7B0D41DB" modified="2017-04-12" version="1">MKFTNSVAVTLATAGSLVAAHGHGHAHFHKRAVETETETAVTAGPTVYDFVVLDPSKSGTPEHMSVDEACSLLAKHELEWLGNAIPNACPTSTSTSTPVSTSTAAPTTTIAAQVLLETSAAITPSSSSTSTVVPTTSAASSTSSAASSKSSKTSSVTGITAEFPSGEIDCGTFPSDYGAVALDYLGLGGYSGIQYVTIADAVISEIVTAVTGDSCTSGAMCSYACPAGYQKSQWPLTQGATGQSIGGLECKNGKLHLTNTEYKTLCIEGTGGVNVRNELGDQVAVCRTDYPGTESETIPLSALAGEEHPLTCPNGATYFKWEGKITSAQYYVNNKGVSAEKGCQWGDGSEPIGNWAPMNLGVGYSAGSTWLSMFKNEPTTSANLDFKIKLVGDDLSDNCRYDGAGNFYNNAGLITSGNGCTVSSSSGNAYFVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKY8</accession>
    <name>A0A1Q5TKY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-terminal amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKY8"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="402" mass="43426" checksum="A05AFEC9FB13C56C" modified="2017-04-12" version="1">MRIATLQFAPKLGDVEGNINRANELLKRGKHVSIDGQTRGIGIGIDLLRPDILVLPELALTGYNFPSKEAIKPYLESAGAGPSATWARDTAKSLHCKVCIGYPEIEHSDDEAEPKYYNSLLVVDKTGAVIHNYRKSFLYFTDETWAAEGSVELGFRKLAFTPCDEPESKSKSTTIPTASPVQQEVPTSFGICMDINPYKFEAPYTAYEFANRVLDSGSQLVILSMAWLTLMGKEDIAALNGKPDMDTFSYWLNRFMPLLEKKLRHEGDIDRHTDSPGASSEPGTKRTVIIFANRAGEEPAADDTKSAARYAGTSAVIAVTQRARMVASGSGSGSRVEGGIDGGEEGEGECAVEAKIACWDLLGAGEEGICFADTTAEPKMVFGLRRRGGSEESSGEESEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKZ8</accession>
    <name>A0A1Q5TKZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF5">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="111"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP00905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="482" mass="53907" checksum="A3A944F09817F163" modified="2017-04-12" version="1">MAPARSPSFRMPYAHYALIYLDNEGKLKVEESASIQEQNSTIFTPEVRQNFLEILGERIGYQPPMRRTLNASPRRVRRRGNAPSSEDRLAEAGSDSDDCSPNGSNEMVPLRIGDTAKVLTYYEGALKHFQQLNCRMVAKAFIKFIEPRKQVRHPYNGGKPPAGSAPGTTGDPEKTKPEWWPPGVMHKEPDHLRKEYRIELLLHIIRKLGGYGVTADKLKEVAGDTKRSLKHASHVDIIYEILRVRKMEERFERGEVDANIVVYVMNRGPSPKGDDEEESNETTTISSMPTVEVPEPIEEGLLTPTSSIEQITAPLTTPIDTMAMVPTRSLPTSFSIPQPLSFDGPRQDRSYYATPPHYTDSFSQPMLSAPVTAEMISPHDISVFDYPTSHFPTSTPDQKFDGWAPTFRQTLFSPVDYNAPSVTHGLPQPGMQYHMPMASPAQLHDMSHPHAHSPMDAMSQRALPFRTGSLGHPHELPLSHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM79</accession>
    <name>A0A1Q5TM79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="175"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="303" mass="34051" checksum="08B4AAFD8B6AD84D" modified="2017-04-12" version="1">MSQPASPYPTQSSFYSTTTIMNPSINPDTPPPPPPKPSSHEASRRGTPQNMSSMPTPQQPQPGYRPDPHSANSQQAQYQVNAQLSLPAPPTIEEGWLPDIVKDKSTTDLQSILQNPTLISALSAQHPSHTTRQQNLESLLQVNKDLAARLLELQSHVSDLRSQTETMLLTHQSLEVSWRKKQTEMDAALAPWSPKALYQRLSAAITEQEAVCQAVEESFLDEDHHGRATEKEITDWVRRIRVEASKLAARKEAKARWDEGRVGGWRVVIQGFQSPEYGFNQDVVKTLFKGMQLIDHIQLQFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TME6</accession>
    <name>A0A1Q5TME6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TME6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TME6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="52"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="312" mass="34814" checksum="D24E3EE6D6BB60BD" modified="2017-04-12" version="1">MSCLFRFVSSYKVPTPPVPPKTSPRSPGHSVRAIVYHPTGQTSQSEGRPLHLNIHGGGFLGGLPEGNAPFCRKISAETGAVVVSTSYRYAPRYTFPVAHEDVQDVADWLIENSEKLWDADPTLMSVSGFSVGGNLVLGIAQRLCPSEYRVKAAVLFYTPVDFRLPPWDKPKPAGFPEKDPLSWILPLMDAYAGPERAKYIKNPLLHPILADIETLPRNMSIVGGKVDILLHEQTVFAKRLEEEAEAINQGAKSSINSKGETVDDLYHIESEFFDNQIHGWLELPSMFIDAKLRDRIFDDAIHFLNNVYNTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ47</accession>
    <name>A0A1Q5TQ47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase SPAC5H10.03</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ47"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32286" checksum="FE2BD9CFCAB5A1A0" modified="2017-04-12" version="1">MPPIIYAVRHAQGVHNLCTANHVIPDPLLTDLGHEQCAKLQNAFPNHAQIDLVTASPLRRTIYTALESFGPVFESHPDMKLIALPDTQETSDVPCDTGSEPEALQEEFAGKPVDLELVHKGWNNKEGRYSPTNRALKERARAARRWLKARPEKEIVLVTHGGFLHYFTEDWEDSSQYQGTGWVNTEYRTYTFTDEAHNEDLEGHPLDGDNATLTETLESRQRRGKAGPMPGREQQKTLYKLGTQGWDDQGLQMSTAERDAAKVPGGKEVDGTLALFSLGDTAAGTYIDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRN3</accession>
    <name>A0A1Q5TRN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anucleate primary sterigmata protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TRN3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="528"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1410"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1524"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="848"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1224"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1463"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1524"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1567"/>
            <end position="1576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1583" mass="177062" checksum="99238069E981CFE7" modified="2017-04-12" version="1">MSTKASTPLVTTPPIVIPGPPSVRIPSSAHDSGAYHSPHDLSPLDADFSASDYFMAEDARGAGPPSTSFHDAETVTDDKSGAQDSITTPPAPTTNSNTTTTTTTTQADNEEKDVHDEPPATIAQSHTEEEISLLPPLTDRDDSSLFLSSEIGEREHVNNQTLIEEHEMRRKLMDMESSFLPEPSTIDVATAGRTTGADDTYLVGVGGYDPDMTQSSTFSFIPPSESYGEIEHDHDGAGEGTENVLDAARAQQSGNDTMLDSLTSSPSAAAMLRSLQRDQQSENPAENSLLSQDERPFRSQFSIAESESQLTPSKLRHSSRSLSPGSSRIFSDQTGGIGGSRRSGSRPKYLTSRQSSQRLSHSSIASNNTETTHSDATLGADFALQSGGAASEQWGGLNTGQRAHMTRTTSLGSMASGVSGYSEENSLERRTLGAPIDGGLHTLEEESSPQSARQAPAFDEASAPMTPKARPRDNIPTDIAITERVKGIQVPTAFVQRFRDDFAHTGPSPEKRPGASTPAFGRSGRTMTLKEQSSTIDRLSKENFDLKMRIHFLNEALNKRSEEGIKEMISENVELKSDKLKLQKDNQGLKRKIRDLEKQLKDQQSDKDSMVNHDPEASEDDRDSPQDEELIFLRERVETYELEIERMRSENIARESEKRRLAEMVKSLSENRTAGSDAGAREERDMWKDMLEAETAAREQAEEENRRLRDESIRLKSEIYTTTSSLKPGQRERGGSTVSYASTSEREGHRGALMSTSSSTLMVELELLKQENAELRKEVSAQTSMLTSRNREKERLYQEIEELKLGQRRDGSRSVAGDSIFDRSVSRAQMRAGSEISDGTGSRDNMDREELEARNGQLRDQVSTLKLDNQAIRDQLESYTRELEALDKAYQADVDQAEEEIANLQHERDQAIQMADERDAAFQDLRAEAQEELDTLGEELDQKILECQRMGEDLRNQDESLRVLQAEMRSASEGIIRLEEDAQNNLERYKAVQQELEETNREMESLEKSLFEANTKVQRLTVQIESSQNEIAFLREEQDGDKIRIGDLESELKTYHMSLHSEKDKTRELEQRLADERHQREVVGSKEKQEVQRIMNELNREASAAKEEARRLKKSLSTQEIETNTWRERLMDLENNLRETLGDLSGSRSSLITNIMKLQKELESTALELESVRQQLDEKESLLRNRDALLESHGLESRKLSELLERERQARRADKQSFEQALKNHQQASRTITQSNSRITDLENARNSDRKRFTSLEQQFRDQLSERNALFLTIWKRLSSICGPDWAHSNSLINGNLPSQEVIGNILFWPGFSRNLLLAVKTVESVISGFKTRIRGIEHDFTKQYQNLESSFAQRVRRLERIEEAVKNLRNGRGYSSSASEVSKLRGENRLLKAEINLLQSNTRTHSSASAAAAVMASGPRSPSLASTADAERSSLTRHNSSPGTSEKPRGLTRSSTGLPQPSHTSSSSTLTNNAGAILPRSRSGVSGWDGIEEKWIHRLHELERRLKSEREGRLLDRSGARKRLEERDAENQRLRDQLQRERVRRGGPSGTVTESSRSRGVPTSDEGPSSSEGEGITVDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U084</accession>
    <name>A0A1Q5U084_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_6581</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U084"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U084"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012479797" description="AA9 family lytic polysaccharide monooxygenase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP05861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="366" mass="37433" checksum="BE5E1D2741BAF3B1" modified="2017-04-12" version="1">MLKVVAPVLMATLVAGHGHVTNIVVNGVSYQGWDINSFPYSSDPPTVVAWGTPNTGNGFIAPSNYGTSDIICHLNATNAKGHAVVAAGDKINLQWTTWPDTHHGPVIDYLANCGDSCETVDKTTLKFFKIDGVGLVDDTTVPGTWGDDQLIANNNSWMVEIPPTLAPGNYVLRHELIALHSAGSEDGAQNYPQCFNLQVTGSGSAQPSGVLGTELYKATNAGILVNIYTSLSTYVVPGPTLISGAVSITQATSAITASGTPATGAGGAVTTSASAGQTSSTTTARTITSATSTTTSSATTLTTKVSTSSTTLVTSKTTTTAASDSSTQTVYGQCGGSGWSGATACVTQATCTSMNPWYSQCVPTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B4</accession>
    <name>A0A1Q5U0B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_6611</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0B4"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="7"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP05891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="490" mass="55482" checksum="C2C221C14C5338FA" modified="2017-04-12" version="1">MSNPRFTFAEGQPVSDPSTSITLPTLGGGGITTLGDTLLIETLTHFNRERIPERVVHAKAAGAWGEFEVTNDVSSLTSAKFLNGIGKKTPVLFRLSTTGGEKGSADTVRDVRGFSVKFFTEEGNHDIVGNHIPVFFVRDPIRFPSLNRSHKRHPSTNRPDWTMFWDFHVNQPESVHALMHLFGSRGIPDSIRRVTGFGVHTFKMVTADGRFRYCKFHFRPVDNITHFSKEEATRMAGVNPDFHNEDLWGAISRKQYPVWKLYVQVMEPEQAVNYGRGLFDITKVWSHKEFPLIEVGKMTLNKNPENYFAEIEQAAFSPSNMVPGIAMTPDPMLQARMFAYPDAQRYRLGVNYTQLPSNRAVCPVYAPYERDGMSVHTRNYGGDPNYVRSTLSPGIPSQVTSDVRHTEPIERFAVLGQNEIAVDDEDYVQPRELWNRVFDENERKQWVENVSETLEAVPAELRQAVIAMFSKVDSRIGQLMTAKGKEISHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0Q7</accession>
    <name>A0A1Q5U0Q7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-glucosides permease MPH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0Q7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="57"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP06053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="577" mass="64458" checksum="6463B1E0DBEE9BDE" modified="2017-04-12" version="1">MATDMNRTEITLEKSAAHHLEDTLGVGAVLEAKQATDEEHEQTLWQALRANRKAVTWSVLISMSIIMEGYDTILMGNFFAYPTFNQKYGHYYGEEIGWQVSAPWQTGLNMGSTIGAIFGELWDLYRTCGCDSRLFVLTWPFSLGGLLNGYFASKYGYRMVMIVALFFMTAFIFIVFFSNTTAVLLVGQILCGLSWGVFATVGPAYASEVCPTKLRGYLTVYVNMCWAIGQMIASGVLYGLLQRSDQWSYRIPFALQWVWPVPLMVICWLAPESPWYLVRNNRLEEAKNSIRRLGGDKTEDQIHGQLAMMVHTAKLESEIEGGTTYTECFKGVDLRRTEVCCMAFAGQILSGSSFAYSPVYFFKQAGMNVNRAFQLGVGCTGVALVGVILSWWLITFIGRRTLYVWGQGTLSMLLFLIGIVSATSHTPGALWAQASFCFLWLFVFALTVGPITYAIVSEISSVRLRPLTVSLARTAYQIVNVVSQVLQPYFMNPTAWNASGKTGFFWGTTALLMFIWAFFRLPEPKGRTYAELDILFATKTPARKFASTHVDPYAVGASPSQEGLVRPEAAVTQERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4E1</accession>
    <name>A0A1Q5U4E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4E1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4E1"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="901" mass="100745" checksum="4344CBD18287BAAF" modified="2017-04-12" version="1">MDSYEGYDASPGKNRDMDSFGGRGAPAEYRRRSPASQDRRGRGRGRSRSPMIDRYEPSERRPREDFYNNSREHAARDREDRRRPPSPNVVNIDRYIPGQDSGKRPLPTNPLPDPLSLDFQVGFTWFAEWWRAEQAISEEKDRAKNGGRRPSRLKGEREALEDRDKERAQIQAAYDSYKVDLQIKLARAFVQQHREEEWFKERYNPEVRDPIRDRLLNFRKGAYEQWERDLNGGLFDDFTLEGIYKSESDGAGGVIEKEEGEATAVGETLGVLDLLPVRGGELRDEALSQPALLIKTLAPNVSRDKIEEFCKEHLGENDGGFKWLSLSDPNPSKKFHRMGWIMLHPGGDTTSYVDRGDGRDEEMDHDNGLGETVTVNAAQKALDAVNDKTIHDPVHGDFTLHVGVHAPPAQLRKKALWDLFSAPERIDRDLELARRLVARMDGEMGDVDGFSKIEERVEDLRGKGWLQPPVTGPVSVKKHKNGFGKDGADDGEMEEGEEREISLDDDVDDEEILAKKKKLDLMVEYLRRVHNFCFFCVFESDSVHELGRKCPGGHLRRPRTGLSTQAKEVARASALGQPFPVRKKEPSEDGEERASPVQERRPQRVPKSEQQLQRAFNWVKTFEEKVLQILEPENADLRKLGGKPVEEALDEELAKYVKQETDDRYRCKVPECTKLFKAENFWRKHVEKRHAEWLDKIQRNLSLVNAYVLDPSRIAPSRSDANSNGHFPLASGHGQGGTPRGFSLQNVPYLGNPGALPSGFSPGGMPGIVGAGGPWGGNGIATGDGASLHQPGVMRRGGHRQHNHRSGPYDRRRPPHGTGRLSPVRMPGMYGLGGRLPPANFSVPAGHPAANMVPPNPFPDSMGGGGGPQGIPPREAVQGRSLKSYEDLDAVGGSGSGELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4E6</accession>
    <name>A0A1Q5U4E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4E6"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="286" mass="32780" checksum="FED9FEC75372B645" modified="2017-04-12" version="1">MPRKHPKPPNHPIKSADRLALAITGLKTGKYTTIHDAATQNAVPESTLRARVKSAGFPRRANTRNTRRRVKEFRLTRTEENTLSNWIVQVHEGGNPIYPRLIQDMADTLLEKRGGTHGFRVTREWVSGYIQFHPEFAALIEQHNEYLEKELGMRPFRLGPDPDNPKDVLEYAVDGLHNTAQFAKQMNEFEKTMQKDLRERMVTKGPDHVRTIAAALEEWRQEVAKVLESGVEQCSELGELLLNYELDTSAFVNGYRELLCINRDTEEVQEEMRVEFGGKVAVEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4N6</accession>
    <name>A0A1Q5U4N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Quinate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4N6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013180242" description="Quinate permease" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7035" checksum="23334CCD945F19AE" modified="2017-04-12" version="1">MTCNFLLAVFVWFMIPETKKVPLEEMDTLFGGTSHVQGGALILDVKHADEAAERGERVTRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U780</accession>
    <name>A0A1Q5U780_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U780"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U780"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="36215" checksum="0251B9020B8790B4" modified="2017-04-12" version="1">MSSVYKFTVWRGQKDGSIAEDTTERPALTGDQVYINVTHSGVCGSDLHCIPFGIALGHEGAGVVEATGPEVKSLRVGDRVGWGYPFDSCGTCEKCMDGYPTICDTPVYYGTANLDSGSFATGAIRKESFVFRIPDNMPSEQAAPLMCGGITVFAPLMLCGVKPSDTVGIVGMGGLGHLAIQFARAMGCEVVVFSQTESKKEDAMKLGASCFVTTRGKTDLTSDVSSKVHHLLVTTAELPDWDLFFPILAKGSAIFPLTATGPEAQLALPHMKFLVNGAKVQSPMPSKKTYSDMLKFAARNNIRAIIECEPLSTEGINKTLDRLKRGNVRYRGVLCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U784</accession>
    <name>A0A1Q5U784_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dienelactone hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U784"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U784"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55879" checksum="E1647D359F781B92" modified="2017-04-12" version="1">MATVSINAPGLSGGLLYNNGSNNARVCITSETGEFDMETIKNWQDEGFDVVYLPLDAGGKDYESRLKGVKEGLGVGENYAVIAYGEAANYCLDYYLKSQNASRLCALVAYYPSVIPDTRSRFPLSLPVLVHLAGDTVDVTTIPVALGLQGKKKRKTRPINPGIGTGERLELAYPAYTYDHAQPGFAEHDMEEYDHLAADLAWTRTIKVLRKGFSREADLERRWEEHQEGKYFGSNITKTMDAYVLQKKPAVTYVPTVSGGIGTQALRRFYEHHFIGKLPPSMRIRLLSRTTGADRVVDELYVSFEHSQEIPWMLPGVPPTNKRVEIIIVSIVSLRGGRLYSEHTYWDQASVLVQVGLLDPKLVPQSAQGVDRLPVVGREAARRILHENPEEEQVDYHNRMIRRARALRNRSARASQAGEESAAELKSEAETPMPIREKKKGKSVQEKGDSGPAQIDAKDGAADESNGNADDDDGAVTETESTAKAKPEPADHKAFVEEGSDENGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7Y8</accession>
    <name>A0A1Q5U7Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7Y8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7Y8"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP08566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1263" mass="135773" checksum="63A65670BD65CB33" modified="2017-04-12" version="1">MNPGESRAIHPDGELFLNNTNTTTSSSGRPDRQIEPLRINKRDSASPQSASSPPNIPLPYPDDRPRPQLRSSSSHDARPTDGLRYNSPPPASAGSGSGSVSPADYPSALRPRDGREPRVATLAERRGAAPKPLPESPGPDAPDAAALAARPYPRPPTASAPVETGEQQYDYRQQYYPPPVSASSRPGSNLAPPSSSSGINRISSTASTSTTRAQRGSPPPPETPIVGPGQQPGSDIEARYAAAGIAGTGTLAGLQSQSSAAAQRRAEQYVGQQPTFSQQDSQRPWTPTELPGSQPHGPPTVYQGAEVVSPGQGVAQVQQPGQYGSPPHQHPGQYGTPTPQHPGQYSSPPPQHPSQYGGPTPQHPSQYGSPPPQAQQSQLAPLDQSSRIPANALEHDIDRMRISDEPPPAYSSVSGAGAANGYPNEKPGVAAVGVAAGTAAGAAAGAIAGHPAIVNQGHPAITSAPSPAPTASTEGHPAFANDLRQQSGAGQSPQSAVANGQPQYPQQQQAQQPVQQQASYPAQVASPGPSGPPPASPPPLPEGWIAHLDPNSGQYYYIHLPTQSTQWEFPKGPTPLNLNETPLSPVGSVYSSHPLTSPGLSAFGKPLASPGVPLTPGFESLQSPMAGFTGPPPSSGMDIYKTAPTNGVYFGPYLRYTNMDLERGLWLGSILLVTDAAQPPTIHLHQSVDLSPNPRQLKAINIAAHQRWTFYKYEIDLQMDDAGPAKWTYAITSHLGCTRYEFLVAGRHETNWRFIATSGNDFSLNVNANERARLGGVGFMWKDIMQKHNEIGGFHTQLCLGGQIYADRMWKEIPCLKQWLAISGKEARKNAPWTAANQQDVSHAYFHYYTSHFDQPYLRESFAQIPYICQIDDHDIFDGFGSYPEHMQFSNMFKNIGRIGIEMYLLFQHHTTLDILRNVNNDTDLFTITGTGWHFVKYLGPGVVVVGPDCRSERNPHQVMAGPTYQGLFPKVAMLPPSVQHCLWMVSMPLIYPRLETAEHIAQTVATGKRAVTGAYNVLGKVTSSVAGVVGAKEFVGSGFDSVKRAVGKSGLMGGILSPFGEFDLMDELRDQWTHESKDLERTYLIRTLQGIAHQKSLRMTFLSGAVNVCGAGLVHDPSQPTDHKTMYQLIASPVVNTPPPSYVVKLLHSNSKPLYVPANGHRSSSTPTDTKEDMMEIFQTDVNGQPREHKKLMARRNYVAIVAYDPDVVSTPAFGMQMHQQAFSAVKAKLSLAADFMVQGDGAYANVVKFGPVIVPCLEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA25</accession>
    <name>A0A1Q5UA25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Copia protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_5323</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000543">
        <property type="protein sequence ID" value="OKP09332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA25"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA25"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="420"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP09332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="53185" checksum="973754AE2A0CC375" modified="2017-04-12" version="1" fragment="single">MERLEVLEKMAAGIKIKPELAEPPALTPEKCEVCEKSKTQRQVSRRPAGRTHVHGKFGRLHFDLVHIKDGYNQHQWVSHLYCEGIRLHLAQTHEKKNGCINALIAFIAICRSQFNMDILVLKSDREPTLHSVFHEYCPEAGISVEFSVIGTPEQNGFIERAGGIIITTARALIQESGLPKKLWPEAITAAVYLLNRVPTKMPTGEYIIPWVEAMKQRDPSIELRPNLANVKLYGCRAYVRIQGIASSDKMAARAETGYLVGFVASNIWKIWLPRLNKVVEVRDVIFDENVRYSDTEAAQPIPQDVLNDAIWDVQYEDSEHERPQYDLDDIALEIPPSLLPSATQNETSVSHQEELVRTMDHSLTKTQHNHINSTPPPMMTPSPTPTPEAPRNEALPGAFPIDRTEAEGVRALDIDANPDQQLLGDLSNTLHQPVTPPPGYRLRGELAPRDIEGSVTTDNIIEGSRTRSKRAHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAC7</accession>
    <name>A0A1Q5UAC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_5252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAC7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAC7"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP09430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="556" mass="60635" checksum="E40606AA37DB95C2" modified="2017-04-12" version="1">MSGSSPGAHLPVHPKRIPYWHLLTDHGAITQDILDYEYTGSGTEADPYAVAWIPNDSRNPQLFSSARKISITLTVAFASLIVSLASSAYSGSIHEIIADFKISTPVATLGLSLYVLGFAIGPLCWAPVGEVYGRQVSFFISLLFMAAFLAGCAGARNIWTLCILRFFAGSFGSAPLTNGGGTISDIFSARQRGLGLSLYAAAPFLGPSLGPIIGGFLGMKAGWRWVEGFLAATAGFVWLVSTLLTPETYAPVLLRKRAERLSRITGKVYRSKIELEKGPVTTAELLRKTLSRPWVLLFKEPIVLLSAVYVALVYGTLYMFFAAFPIVFEQVRGWNPGVGGLSFLGIMVGMIIGIICTIPANLHYTKVQSQRGGYAPPETRLIMCMPGALAIPISQFWFAWTNYTSIHWTVCIIGTAPFGMGVILIYMGCMNYLIDSYTIYAASVLAANAVLRSIFGAVLPIVSTWMYDAVGIHWAPSIPAFISLLFLPFPFFFYKYGAAVRAKCKYAAESDQYMKKLAENSIEEKKKRASTAEPEASPSHEIPTMEMERVATVQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBI4</accession>
    <name>A0A1Q5UBI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000438">
        <property type="protein sequence ID" value="OKP09842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBI4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBI4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="557"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="732" mass="82812" checksum="B5606B560F8314AD" modified="2017-04-12" version="1">MPLTLLGPVSLSEGSKRLAPETEPIAMRTRKRMKEPSETQHSTTTEDSAQDIDEVEKGTDEVQQRRGEPPIWANTRQQLTDALEWYRSMQGGAAHKEKKCTGFLLDGDNGDRSFMNDEVFITRMGGGCEKDQAGSLHLKMDQSPNGVIITSIMASFQEQKPVGVVIGSNNTLLRIEIPHRYCVMDWFLITDVWMEKMGKYAGYRVRLEKLNLSTKGWWTKQGSDESLPLRHSNQPPPSQKCGQCGKSSVQIYVRPGWTCLEKSCSKFWKFRDTEPKDFEFHPDFLDYRHPRGPDIPNPGPLAKIVDRNTEPLEGIADREEWRGIVCPECRKCIQRVTWDSWDCANDFSRGPRETCCYKVVRKMREIPLESVLDGVKPYTSRQMEGKLEPVVDKDSLKPYEVRTYQLPGVGLITHFVSNASINGRTDGPNDMFGQLQKLDLGLRRYPLGSAQGEHASDKARAEPAKATLAKAKPATPKRVNIKRVRAKLVKAKPAQLRKLNHHHLNANIALVGVPYKYVVSVDSKAFSDAPAEILTALGRLSWATDNAVTRAGDQYQPPNELLALGYFKNMKIGFHDDGESALGPTIATLSLGTRSRMYIRMKGKYYFGVSNSNIPTPGDPVLPRCIKEEQRRSLKKDFEADRITNDVYNKRRKAMLQRSNTKQPPKLLTLELKHGDLVVMHGAELQKYYEHSVEPDKGLRFALTARYIESKNEADLQKGEFKLQDNQIYDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC81</accession>
    <name>A0A1Q5UC81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxygen-dependent choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC81"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012547418" evidence="7">
        <location>
            <begin position="20"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="125"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="9">
        <location>
            <begin position="498"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="646" mass="69657" checksum="5529311EF3FA202F" modified="2017-04-12" version="1">MLFPRLFSLAALSASLAAAVELTGYEYVVVGSGAGGGPLAARLALAGHKTLLIEAGDDQGLNANYSVPAYSAKASEDGAIAWNFFVRHYADEERQARDFKTTYVTPEGEEYTGLNPPAGSTMKGTLYPRTGTLGGCTAHNALITVYPHESDFDYIATLTGDGSWSPANMRKYFQRMENNKYLLPLIPGHGYDGWLSDEEAPISIVLEDPQLLSMLLGGAFALGNHTNAVFNIATLLAADANRDSKSRDTNPGYYQVPIATDGGKRNGPRDFLVAVRDAKNFDGSKKYPLDIRTNCHVTKVTFENDTSTSTPRATGVEFLDGKYLYRASPRSATAAKGVPGSATASREVIIAGGVYNSPQLLKLSGIGPADELTKHGINVIKDLPGVGTNLQDHYETAVQGHVPKNFSALDGCTFNAAHDPCLTRWKNPILGNRGIYSSAGFASTMFYKSSVTADDSYDAFVFGGPVNFRGYFPNYSINITERHDWFSWAVLKAHPRNTAGSVTLRSADPLDMPEIVFNYFDTGSGDYKADLQAITEAIGLARDAFDRQLVDVTEVLPGKDVTSNEDIHNYIMDTAWGHHASCTCPIGADDDPMAVLDSKFRVRGVSGLRVVDASVYPRIPGTFTAVSTYMVAEKAAEDIINDAGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC90</accession>
    <name>A0A1Q5UC90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC90"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="50" mass="5800" checksum="E385A7F8C3B75AF2" modified="2017-04-12" version="1">MSTWWFRDGRVDNCRSFAAPSSEWPLPPNARPHEESIGVLPYNYYGTPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCB7</accession>
    <name>A0A1Q5UCB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_4467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000391">
        <property type="protein sequence ID" value="OKP10113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCB7"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="483"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP10113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="629" mass="69575" checksum="463945742A14E219" modified="2017-04-12" version="1">MAGSDEAAAATVNKRPHSEVDAADNGDDSSSDDDFGPALPSEAAPKKKRRKLPFEKVYINALPASARYSKSLMHKDQLSFVTVTPFTDFVITSSVDGVVKFWKKMADGIEFVKEFRAHPGEIRSVNVSADGRSFATAGVDKTVKIFDVITFDLLAMYTLEFVPRCVCWVHRRGASLPLLAVTDESSSTFQVFDGRGENPQPLHTVKSVHRSPIVSMAFNNAFDCVVSADESGMIEYWRTGDGSFEKPDNVFELKSSTNLFAFKKAKSTATAITISPSGEHFATVSFPDRQIRVFEFATGKLYRTYDESIATIMEMQQAGTAPYQLEEVEFGRRLAVERELEGEATRSKFNVSFDESGHFLLYGSLYGIKCINTYTNRVVRVFGREEPFRALNLALYQGQPQRKGVVTVSMAASSNPLLQEAEERDAILVSTGFAKVRFYLFTNETDISKSSRDVQNEKPTQVVGASDAGAAKPQETGTAAVLHTTMGDIHLRLFPTAAPRTVENFVTHARQGYYNNTIFHRVIRKFMIQGGDPQGDGTGGESIWGGEFPDEFSSLRHDKPYTLSMANAGPNTNGSQFFITTEKTPWLDNKHTVFGRAVQGLDVVHKIENVKTHKEKPEVDVKIVSISIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCF6</accession>
    <name>A0A1Q5UCF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000390">
        <property type="protein sequence ID" value="OKP10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCF6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="214" mass="23559" checksum="9A91C4066A411C65" modified="2017-04-12" version="1">MTQVEEDWLRDEPDHLDSDADTEIMTTPEFYGSLTGGNVAYPGKHEAAIDSSSLHVSNRSIDSEDPKGLQSVEQLQSGHQTLKVTQNLCDDPLGAAGSEGFAIKASDYEERQEFFESVVLNFHSDTVDPKVFLTCSALSSAEHSPHSPARSNSERAPSVTSETITLEVTEKAGFSEEKLPLISSAGFLKRKLLYDDQTEPRRSARLAQKDKIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCN0</accession>
    <name>A0A1Q5UCN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Repressible high-affinity phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCN0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCN0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="577" mass="62607" checksum="5DD6E22CEFD54CD2" modified="2017-04-12" version="1">MTSHAVDHDVEAAPPTNSELSSVMDPNERRRAALARIDEAKFGWYHVRAVIVAGVGFFTDSYDIFAINLAVSMLGVVYWQGAKSGAGKLPSSADTAIKVATSGGTVIGQLFFGWLADRIGRKRMYGIELMIIILATLAQSLSSDSPGMSIVGVLIFWRVVMGIGIGGDYPLSSIITSEFATTKWRGAMMGAVFAMQGIGQFAAAIVALIVTAGFKESLMTAKDVAHCSGVCQLAVDKMWRTVIGFGAVPACFALYYRLTIPETPRYTFDVTRDILKADEDIRAYIKGHPEGHPDEMQRIRVLRNESIEYLAPKASWADFRKHYGQWKNFKILLGTAGSWFFLDVAFYGLGLNNSIILSAIGWTGGKNVYETFYRNAVGNLILVCAGAIPGYWFTVGTVDTIGRKPIQMAGFIILTIIFFVIGGAYDSLKTHNGGLLALYVLAQFFFNFGPNATTFIVPGECFPTRYRSTSHGISAASGKVGAIIAQCVFGPLIHKGAKPGSGASPWLNHVMQIFGGFMFCGVLTTWLIPETKRRTLEELSGEDHGSIHESLTTHPAEKPEEGTVPKQVPATTTVQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD61</accession>
    <name>A0A1Q5UD61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000350">
        <property type="protein sequence ID" value="OKP10401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD61"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD61"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18230" checksum="9516ACA87CE7186C" modified="2017-04-12" version="1">MESTQFDDTLLPVFAELDMAIFMPSIDLAAPIEAPIEAPDDASDDAILVPDITWPTYLAAIDWINDQACLSGSGFGAVIKNSKKRRNRALKTVYLRCDRGYNRPKARGHPKRESYTKAKCQWRAVIRLQPTGDWTLRVQQHRHKHGPIPASAVPVPRRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEB7</accession>
    <name>A0A1Q5UEB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_3634</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEB7"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="51"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="201" mass="22184" checksum="270AB238DBBAF85E" modified="2017-04-12" version="1">MPGPLSLFSVNAVLVMSADDGSRIFTKYYSAPHPPTGTASNSTDYPGANPYPTVKEQRAFEKGLLEKTNKSTSDVILYDNRIVVFKMESDVMLYVVGSADENEVLLYNVVLSLRDALGMLFKGATDKRTIVENYDLVSLTIDETIDDGIILETDPVMIASRVSRAPAADAPNMKNIDLTEQGLMNAWEFGKRRLAEGLRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UET6</accession>
    <name>A0A1Q5UET6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_3594</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UET6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UET6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="160"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="363"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKP10990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="558" mass="60137" checksum="DC2EFB9B8121AF21" modified="2017-04-12" version="1">MSYGGGNSRGGDSYRSRGGDNGYSNGGGYSNGGGYSGGGSGGYGGGGRGGYGGGGGGYGGAGGAGGDRMSNLGAGLKTQDWDLNTLPKFEKSFYKEHPDVSARSDAEVEAFRKKHEMAVTGRGVPRPVETFDEAGFPAYVLSEVKAQGFERPTSIQSQGWPMALSGRDVVGIAETGSGKTLSYCLPAIVHINAQPLLAPGDGPIVLILAPTRELAVQIQTEISKFGKSSRIRNTCVYGGVPKGPQIRDLSRGVEVCIATPGRLIDMLEAGRTNLRRVTYLVLDEADRMLDMGFEPQIRKIIGQIRPDRQTCMWSATWPKEVRQLAKDFLNDYIQVNIGSLDLSANHRITQIVEVMSDFEKRDRMIKHMEKIMEDRGNKILIFTGTKRIADEITRFLRQDGWPALSIHGDKQQQERDWVLNEFKQGKSPIMVATDVASRGIDVRDITHVLNYDYPNNSEDYVHRIGRTGRAGANGTAITFFTTENSKQARDLVTILSEAKQQIDPRLAEMVRYSGGGGGGGRWGGRGRGGWGGRGRGGGGGGNSFTASNAAPLGGARRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEZ8</accession>
    <name>A0A1Q5UEZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3494</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000307">
        <property type="protein sequence ID" value="OKP11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEZ8"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="51"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="37176" checksum="7E772A9FF5313D86" modified="2017-04-12" version="1">MQAAQQSWELENAISIFDPQRDALYQYDEATQKSLNAERPWATDPYYFKSVRISATALLKMVMHARSGGSLEVMGLMQGYILPNTFVVTDAFRLPVEGTETRVNAQDEANEYMVSYLQSCRDAGRMENAVGWYHSHPGYGCWLSGIDVATQQTQQMTGPFVAVVIDPERTISAGRVEIGAFRTFPLDFTPPKEGHEDDEYQTIPLGKAEDFGAHANQYYSLETTHYKSSLDTEILSLLWNKYWVATLSQSPLFTSRDYGSKQIMDLSQKVRKAARGIENSGPRGGSATAKDQQLDKVVRGGQRIVSEEVKGLLASEVKRKLFQDIGDQSTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF59</accession>
    <name>A0A1Q5UF59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase Q5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF59"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="463"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="662" mass="76045" checksum="F8C15EF93CE43265" modified="2017-04-12" version="1">MVTGFMVHGTAGPMEWMMDLRRYGMKIHMNTPTAGHIGWANGDELSYKTMRFTMGAFRGFIHGLTASARQLMINQILRCQPDQIPVIPWDRMADDFNQPKAGWSFLQDERTPWPVDGSRWMVDRVQEEHPLQRLFMQANTNRFSVDAIGRFFGFVNEFKEKLAVLVHITSGQPPRGPELLSIRHRNSAAGGHRNVFIEDGLVAFITRYHKGFYASGDAKVIHRYVPREVGELVVWYLWLVLLFVEMLQAFQEEACRLDAVPDTHATKMWGFDAGTGREWTPTRVTDVMVRESKMRLHNGLSLSAYRDIAIAISRRYFGSVKAFPHNVREDGTEVISDNEENEDDMDDEQWVRHIADLQAAHTTHIAEMAYGRMMTQQQGTTAGRQAGFRTSSVHWHDFLGFDIKDIPSSVLGKRARPRWKDDDIQMRDQRRYLVETTNMTEALQRMTGDPTMQFRGVQGAAIDAIKRGDSRVVVVMPTGGGKSMLFMLPAWVGQRGGLTIVVVPLTALRSDLQRRCEAAGISCVEWESHRYPDHAAIVFVTPEAVFTDSFQSFLNRQRDNIRLDRIVIDECHVMLNTSEKFRPRLQQLGQMHRFGAQMVFLTATLPPCEESRLFQRMAVERNVVSMYRARTSRYNIAYRVYRPTIALKYRSQNQWLEDPGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFN2</accession>
    <name>A0A1Q5UFN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="69" mass="7537" checksum="DBDFEE5E4F59F9DB" modified="2017-04-12" version="1">MNPQPRLLGDEAATVGSIFADLSSEIFSNLDIWDRRPRGEIGTNSVVGTFHAPNQPILRTPGGKNEVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGD4</accession>
    <name>A0A1Q5UGD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nephrocystin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGD4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGD4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="351"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="821"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="905"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="964" mass="107936" checksum="2257A2C23A749D9B" modified="2017-04-12" version="1">MESRIRLSNHDYSVGWICALPVETAAAKLMLDEEHPPLPRQPTDQNTYILGRIGGHNIVIASLPSGAYGSTSAATVGTQLLSSFRSIRIGLLVGIGGGVPSGIADIRLGDIVVSQPTDTCGGVIQYDLGKTLNEGNFQRIGMLNRPPKTMLTALTTLRAHHYTKGSRISEFVSNVQAKMMPHNAEIFTRPIQEDLLFQADYDHAQSDLCVNCDRSKLLRRPTRGHQEPVIHYGLIGSANQVVKDGKRRDQLAREFGIYCVDMEAAGLMNDFPCLVIRGICDYADSHKSKEWQGYAAAAAAAYAKELLLIVPIDQTNSILTARETLADRDACFNVPFNITAVLVIENFLGRQDELDQLWEYLRPTDLQSRKVAILHGLGGIGKTQLAIRFARDHKHDFTAIFWLSGKDRGTLLQSLSSILPLLPGQSLNNEEANKKEIEQRAMKVLRWLAIEGNSRWLIIFDNIDQYSPSGTVGDAYDIGEFFPAADQGRLDGLPLAIVIAGAFMRETGINTTEYLEYYQESWSDLQLQSSPIRQYQQGNMLQTWMISYYEIKKRDTDAAKLLLLLAHFDNRDLWYELIQGCCYSSDVPLWLKRITASGLAFNVSVRTLLEFSLLEMKPHRGGYLMHSVVQNWCLHVASSDENISSLQLRKMALIAVGHAIPEARDRNYPELQQRLIPHARHVCRGDWFNCDFAIWGAFHGLGELYFEQGSLKEAEEMFQRALLGREKTLSPEHTSTLDTVNCLGNLYKEQGKLREAEEMYQRALLGREKVLGPKHTSTLGTVNNIGNLCVAQGKLDRAAEMYQRALSGREKTLGPECPSTLSIFNNIGNLYRIQGKLEPAEQMYQRALLGRENALGLEHTSTLGTVTNLGNLYKDQGKLLLAEEMYRRALTGKEKVLGLEHMSTLNTVGNLGLLYKDQGKLKKAEEMYQRALAGFKKTLGSDHNKTRWVRGKLDELNIQMERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH73</accession>
    <name>A0A1Q5UH73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Lipid-anchor</topology>
            <topology evidence="1 8">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH73"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF11">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011826836" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="9">
        <location>
            <begin position="379"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="538" mass="57391" checksum="0C731A3B852E117D" modified="2017-04-12" version="1">MKYSVLAGLSLVGSAMATIPSIEIKGKKFFYSNNGTEFFIRGVAYQADYSSPTSGSSSSSTNYVDPLADVESCKRDIPYLTQLRTNVVRTYAVSPNASHDECMNALADAGIYVISDLSAPSQSIQSDDPTWDSDLFTRYSQVIDAFAKYPNVIGFFAGNEVANKVNNTGSMAYVKAAVRDMKTYIKQKNYRSSLAIGYATDDDATVREQVSNYLVCDTAADSIDFFGYNIYEWCGESSFSTSGYEDRTKEFADYPVPAFFSEYGCNQPRPRPFGDVPVLFGPKMNDVWSGGIVYMYFETSNEFGLVSTDGNNVKTLSDFVNLSSQMQKATPTGVNSASYSVSTTVGRSCPTIDASNWLAASVLPPSPNADLCECMYNQLECVPVDDISVKKMTDTFNYLGGEKGAMDGVSHNATTGKYGAYSMCNPKQRLGWAMNRYYQLNDKSSSACGFSGAATTKKATNPSSCSAQSSAMSAIGSAGTNNVNGGLAASGSATGGSTSTSKGAGAATFGPQAVHVGSWQTGAYAVAAIASGLFMIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH81</accession>
    <name>A0A1Q5UH81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-cytochrome b5 reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH81"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF178">
        <property type="entry name" value="CYTOCHROME-B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="107" mass="11784" checksum="F1A6E2741AC47F03" modified="2017-04-12" version="1">MSLLYANNTEEDILLRKELDEFVMRFLSKFQVQHVLSQAGEGWKGHRGFVSPDLINKYMAPADETNKTLLCGPPPMVNATKKALGGLGWKDPGVFVQGYGSGLVSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHJ4</accession>
    <name>A0A1Q5UHJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHJ4"/>
    <dbReference type="OrthoDB" id="5377172at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF6">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="53113" checksum="998C71A19710EA7F" modified="2017-04-12" version="1">MNVTKNGKTEPGYIFLSPTDMLKGHGSPTIYTDDGEIVWQGQSGHITGFQSQTLNGEPVLTYWNGTVSMLGFGYGSIHFLNQSYEEIHRVTLSDDNLNFKSALGPRFPSYIDVHEDAITNRGSVMVTAYNVTRADLRSVGGPKDGWVHDSQFYEIEIASNKVLFSWSALDHLNLSHSAVPLAGAGHNQSNPWDFAHLNSVMRYGENYALSAHGYCSVYAIDSKGNIKWTLDACLTFFALITQYLIRTSSQGRTGGDFKLGPGTNFCFQHDVRIESQTNKPITLRMHNNDNAPFSKGMAATTGLLLDLDFDAKTASLNRHLWDADEVVYATSQGSYQNLTNGHVLLGHGSVPKLEEYDDAGGVVMRARFGYDNILMSYRAFRGAWSGKPTTKPSVYACVAKSNTGIQQLRVYASWNGATDVQSWEVYLGNEKNKLQKATTAVYNGFETEIRLQTTSNYTLVKAVQGWGSAQSEVVQIEASCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHL5</accession>
    <name>A0A1Q5UHL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional epoxide hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHL5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHL5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="41"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="37873" checksum="A87307F4D2655CA7" modified="2017-04-12" version="1">MPVDKIRVSGDARFEYKSATVNGHKYGYLFSQPQSGKYRATIFLIHGFPDISMGWRYQIPMLVDMGLRVVAPDCLGYGRTDAPDDYTLYSHKRCADDIKALATHLGESKIILGGHDWGAALAYRIALWHPELISHLFTVCVPYARPTPTYLSLEDLVKNAAPNLAYQLQFASGDVEKAVRSKSEIKQFLSALYGARTAKGELGCDVNQGVFLDKLPALKTSRLLSEEELDYYATEFSRTGVHGPLNWYRTRKVNYEEELAIIDRKISIPTLFIQALRDPALPPHLGNSMAKHIPNLTLKQVNTAHWAMWEKPEEVNSIISTWLKDVVFADRRSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI14</accession>
    <name>A0A1Q5UI14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_2360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000248">
        <property type="protein sequence ID" value="OKP12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI14"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI14"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="335" mass="38219" checksum="61EE80DE00DAA240" modified="2017-04-12" version="1">MTTVDVCVGNKYRIGRKIGSGSFGDIYLGTHIISGEEIAIKLESVKAKYPQLAYEARIYKSLAGGIGIPLVRWFGTECDYNAMVIDLLGPSLEDLFNFCNRRFSLQTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKRYRDPRTHSHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYLCRGSLPWQGLMAATKKQKYDRIMQKKITTPTEVLCRGFPSEFALYLNYSRSLRFDDKPDYMYLRKIFRDLFVRESLQNDYVFDWTVYKYQKNAAMIVDASEKDKDNEQAALQAATGNPTAASGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI80</accession>
    <name>A0A1Q5UI80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI80"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF25">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="45036" checksum="3027DE6B0C2CB8E6" modified="2017-04-12" version="1">MKFTSYITDSIGWLAVIGWQAAFASTAYLSGTQIQGAAILAHKYYKPEAWHGTLIMWASLLLALAVNLVGGRFLPRVENLILVVHILGFFGILIPLTTLSDHKTKEEVFTEFLNGGNFASQGLSWFVGMTGCVFAFSGGDAAVHMAEEVSNASRVIPRAIMLSVAINGSLGFGMLIAMLFCLGNIDDALNTPTGYPYIEIFYQATNSIPGALAMVSINLIMAVCIVVGMLTATSRQFWSFARDRGVPGWRLWSRVSSKHLPAYSVYLTMTVAWLLGLINIGSAVALNDITSMAVSGLYASYLIVAVLLLYRRCRGNITEYGESEVTLINVPGAPLVWGPFRMPGLLGILVNIYACIYMVIIIFFSFWPPLMNPSLENVNFSVVGTVGVVIFAIAYYVLRARNVYQGPIMEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIP3</accession>
    <name>A0A1Q5UIP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIP3"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="289" mass="32264" checksum="DC68F583BDF6D30C" modified="2017-04-12" version="1">MAPIRRVATIQWHIKDLAIEENHEAACKYIRQAAADGAELAVLPEYHLSGWVPNDPRWAEQAGEAAKYRANYQSLAKELKICIVPGTIIEKHVGPDEDTLFYNTAYFISNDGTILGSYRKKNIWHPERPHLTSSGEERHEAIDTPIGRVGMLICWDLAFPEAFRELIADGADIVIIPTFWTPHDASPEALHHNPDSEALFLASTITSRCFENTCGIIFVNATGPKENFLGMSQVALPIVGPVAKMGTEEGVCVVNMDLGLLDIAEKNYKVRQDIGKEGWHYLYRHSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIT8</accession>
    <name>A0A1Q5UIT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIT8"/>
    <dbReference type="OrthoDB" id="4493237at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="501" mass="55149" checksum="1D7D9A73A134D890" modified="2017-04-12" version="1">MYEPTTALSLHRLSRQSLQKRYESDEEDVSESDAGGHDFVPSPTGSQRAGIFDSDISADENSHADPDSDREEEFLAPCRGAKRQRPVSMDTVKRNSEASFVEDAYVFDPEEDMVLELPSPDSPDLSSSLFLQPTIYVSPNTPPTTNIRSRSASPSSIFSVENAEIQIAKKITLMEPPTRPTLVFINSLSSRSKNSRSRTSRSRTRGNPRDRESRIFDGRFENGLEVPRLAEIKASATKDTENAESSSDNDSTCTTPAMPTLDDDYISRPLQSATINRVSEIPVVPFLPPSPRIRPQSMYRPRPRTSGAEKSFQLMPNARPRRPTDTSRRPASIRSNSNSSVPSYASLPASPFPSDLGYIPDHFSDVGSLLSRTCSPVSCASSPPPPPSYHSQSQSQPPKRGHTPSKHSVSNILAQRSPMMRRMTRKHSATSSMSSLRSEMDPPVPVPAPSAQMPQTAVNYDSHLVRKNSQRRHARHNSAAPGAGGRKFMGLKLGKKSFTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIW6</accession>
    <name>A0A1Q5UIW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000220">
        <property type="protein sequence ID" value="OKP12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIW6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIW6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="9435" checksum="857D3F3C499C99E6" modified="2017-04-12" version="1" fragment="single">MTNALMNRGIPATSADLISRLHEISSDMDALNINKEERTRRPRSPRQNSDEMDWTPTVSVTRAEPHTKHRRPESGTPRQAQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJC5</accession>
    <name>A0A1Q5UJC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome maturation factor UMP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJC5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="18820" checksum="3377BF090CFDA8B7" modified="2017-04-12" version="1">MSLRIAPPSGNRTSTTNTSARLQTTHSANLSKGAPSAPGLPDTLRNKLTLPATATASSTNNPSAADIPSSTHPLEARLLAWRATQDSMKMESLRRAYGIAEPVRRGMELKIVRDGTFRPAVLGGLKGGNVHEDILVLGGRDMEIGWEDVFQGDDLREPPSFHDEMEKRLKMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJR9</accession>
    <name>A0A1Q5UJR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="63" mass="6891" checksum="94BE707D49CD1574" modified="2017-04-12" version="1" fragment="single">NNNEGSIGSSTPTFSQNQLLKVSGNKGKVQREEIKIADKNDNELLGIQRLSDSEVAEVVKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKG5</accession>
    <name>A0A1Q5UKG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zeaxanthin epoxidase, chloroplastic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKG5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="443" mass="49565" checksum="B4BF3F12E2749FBA" modified="2017-04-12" version="1">MSKSHFQVIIVGGSIGGLTLAHCLRIAGIDHIVLEKSSSPAPQIGASIGILPNGARILDQLQLWSEVEDCIEPLHTATIGLPDGFSFSSSYPQIINKRFVFFNFYLLFRPWTSLTLFTGLHRFGFPIAFLDRQKLLEIIYQRYPDPSKIRLKERVTAIKISDSGATVTTANGSVYRGALVVGADGVHSIVRQEIWRASEKLSSGLTAEFRCIFGISSAIKGLSVGEQVNALFDGLTIVTIHGKNGRVYWFVIQKLDKKYTYPNCPRYTKNDTSVAAEELRNINFYRDITFGQVWENRETASMTVLEENTFETWYHGRLVLLGDSVHKMTPNIGQGANMAIEDAAALTNLLRNLEKLPSTLSSGTAQIETMLRQYRSLRYERVESIYRDSRFLVRFQARDGLLNILLSRYYAPYAGDLPADMASKTIADGVMCDFLPPPTRSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKU8</accession>
    <name>A0A1Q5UKU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKU8"/>
    <dbReference type="OrthoDB" id="4354695at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="106" mass="11925" checksum="DD94BFFAEECECA89" modified="2017-04-12" version="1">MSSISWPTYFAAERATFQRDLRIIIDILLTPGDNAERLSFCHTIADRSSFPGPLSTLHTANKPAGSTKEHLAQRHLSANINCLMYMFIDHPKEGRSSCFRSQLITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKZ8</accession>
    <name>A0A1Q5UKZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_1247</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKZ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="397" mass="43874" checksum="3C825407EB5F072F" modified="2017-04-12" version="1">MPNVGHVLPTNFPRGLSPYSQRFNEPNALAVIANDGSGDNHIFHLYVREKDPKAELWDGARSGTQAAMDVFNADETGNIEQIGDILPKIIAGATEVYSDIPAFDGSRSSLHRYLYGPTVASEKLKKIVDHRRVKPLKPLLNEMRAFKSENEVVHLRLLGQASGRAFTDSMRKTFETEKELSSFLEYQFKVNGCDGSAFVPVVAGGKHALSIHYTRNDDILRDGDLVLVDGGGEHGSYISDITRTWPVNGKFTDSQRDLYNAVLNVHRTCLALCRESSKLSLDKLHGIAENGLKEQLKQLGFDLSGNAMSVLFPHHLGHYIGLDVHDCPGYSRGYDLKAGNCITIEPGIYVPDDERWPAHFRGIGIRIEDSVCVGDDHPIVLTPEAVKEVADIEALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL16</accession>
    <name>A0A1Q5UL16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL16"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF79">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="161" mass="17744" checksum="86B8DC65CB71C132" modified="2017-04-12" version="1">MHGMDMSSSSDSTECQISIKNNGMFAATCIGIILLVILVEAFRRLGKEYDTFLTRQFQRQAAVLAAKKDNCVTRAESVGLGLKFRVTPLQQLMRAVIHALTFAGAYIIMLLAMYFNVYVIICIFIGAGLGKFLCDWMVVTVGIEGIREEIKGVEETTVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULD1</accession>
    <name>A0A1Q5ULD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">INO80 complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULD1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULD1"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="273" mass="28062" checksum="5E52247CDF7D09BD" modified="2017-04-12" version="1">MPAGSTPNGRSNRAGAAKNAPTTLLVTLKLAPKALRQFLDEVPESPETKTPEPTSNPDKPTEQSSPASSTEAPAARPSSADAESNADANSTPATGATPGDTPRRKGIPGPKPGTKRANGQMEPVARVRGRPGPKKKARLDEGGEPGKVSVAPRLGPKANTGAINAHLRALDRSGAPCRKWERQPLKLRSFTGVMWQLPAWGSYKIAKLESDGDKVAAGLENGDSDTKMLNAPGTDTVNGSSAVSSEKSTGDGEVTPAPSNLVEPSSPAIASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULF8</accession>
    <name>A0A1Q5ULF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULF8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULF8"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000222">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="154"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="405" mass="43135" checksum="C3E772BE517DDFBB" modified="2017-04-12" version="1">MSFQNFDSYPNQDAAAAAGAPAQADTNMTGQADPAGAPFQGAAGDAAAAPGPQQGADGKTTLWMGELEPWIDENFIRNLWFQMGEQVNVKMIRDKFSGSNAGYCFVDFASAAAAAKALSLNGTPMPNTNRVFKLNWATGGGLADRSRDDRGPEYSIFVGDLGPEVNEYVLVSLFQSRFPSCKSAKIMTDPISGMSRGYGFVRFSDENDQQRALTEMQGVYCGNRPMRISTATPKNKGPGVGAANMGGMPGPAGMYPPMGGPPMGFYGTPQPMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVQRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGPAGSPYRPAPPPPPMYPSMGMPPAHQYGGFAPMKVSSHPGSPAPEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULU1</accession>
    <name>A0A1Q5ULU1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULU1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULU1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="201" mass="22063" checksum="B3D2A42308991256" modified="2017-04-12" version="1">MGLTVVDFLTSIGVPKVDIIGFSLGGMVAQYIVVSHPHIVNKLILAGTQSSYTEGVVFGDPEIMKIAGGAVPSEEDMMKLFFYPSSTSRALGRAWFERTQERQVEGEQWRGFLDQAGAAKQQAAIGKFATDTELFEKLKQINTAVLVTNGKADIMTPTSNSYILLQQLRNAQLHLYPDAGHGHLYQVPEIYAKQIELFLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULY5</accession>
    <name>A0A1Q5ULY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biphenyl 2,3-dioxygenase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULY5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULY5"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="86"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="429" mass="47429" checksum="1EC9796E7B201ABF" modified="2017-04-12" version="1">MQLLSAYFLSPGSVIVALLALIFLAHQSWPSLSYRKKTYQLSGEISEVHDENDLTVSKDPEVPKGWWSSREVFELERRAIFSKSWLYLAHTTQFSKAGAYQSFDIAGFPIFLIRSKDNKIRAFHNVCRHRAYTITRKETGTSTVLGCRYHGWSYDTTGRLVKAPQFDGIPGFNKSENSLFEIHTHTTDHGMVFVNLDTGQPTPFPDSTASSLDGFVKIAGLGSKSIWLAGQTLTGTFNWKFGMSPQYCTDVTARLEEIVSAASLPSFASKLTKIITRHNSRADCHLFPVNILYSFENAPLWVSISYLPASESITQVRYDLFNLSSKSGINENQLASAVAGSVKGFMQGIETGFQSVTTSPVENSSNTRRILEQLQEHARLEKKSGGQILPAMRQPKGSSLFQQAEQLCKEIDCSGSGSGSGNGSGSLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM56</accession>
    <name>A0A1Q5UM56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baeyer-Villiger monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM56"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="37004" checksum="C021E33823523304" modified="2017-04-12" version="1">MTSFDKRPITKVIVIGAGFSGLAMACQLQRKLNCDDFTIYDRSPAPGGCAVDIPAVFYSLSFASNPNFSKVFPSQAEILDYFNNVAERFDVTRHVVPNTEWEGAYWQELTSTWLVKLKDLSTGQLYYQECKILISAVGGLVNPNQFDVPGIDDFQGDIIHTARWKTDVSLHDKDVIVVGNGYDPITALLPRSIQTKSGREYPADTIVLATGFSLTQYDVELVGRNGQTRAQHWNDFGYKEAYKSIAMSEFPNFFYVLGPNSGKGHTSTIYSIENYIDLIVQVIAPVIRDQSTFVEVKADSEKKYNETLHEAIGKTIFNNSCFSVSTHRVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMD6</accession>
    <name>A0A1Q5UMD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carnitinyl-CoA dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMD6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMD6"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29711" checksum="69444542D7214A7D" modified="2017-04-12" version="1">MSLRSRPSQYQHFNVTFPHERVVQVTLNRPDKLNSITQATSREIQEIWELFDQDESLWAGIITGSGRAFCTGADLHEWNEMNRSGVVNKMTAPGLAGLPRRSGKKPIIAAVNGICMGGGFEMVANCDLVIASSSAIFALPEVKRGIVAVAGCLPRLTRTLGLQRTMDLALTGRSVSAKTLYDWGLISRLVESGDDVAQAALALAQEMCANSPDALIVGRQGIRLSWESGNVEEAVTTLENDWYPQLMAGHNFGEGIQAFVEKRPPKWVNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UML8</accession>
    <name>A0A1Q5UML8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UML8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UML8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26455" checksum="54BD7E5BFF261465" modified="2017-04-12" version="1">MSELQEESTEKVINILDDTPETIERVLSFLYLKDYSEDGPILQYRPIPELTNNESHLYSREKARNTEPENTELRNQSAFTNIEVFIAADKYGIIPLKTLATLKFSRWANTSCGSPVFDEVIEKVMTSVPSHEPTLQEVIADVFCRHILDLIEDPEIVHTLDSFGYLGSLVIARLVGTGMVKRPNESDIFQGLVQKINSSRRCRHCLKDFNVSIKGAEYLYEVFRCASCNTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN06</accession>
    <name>A0A1Q5UN06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN06"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="317" mass="34470" checksum="5DA59D3CA5A25420" modified="2017-04-12" version="1">MQILITGGAGFIGQLLAAELLNDPSYHVTLTDIVQPPIPKGVRHPENATAVKADLLTGAKDVVNSSLDAVYAFHGIMSSGSEANFDLGMSVNIDATRNLLEALRHTCPGVRVIYSSSQAVYGQPLPEIVTDSVIPTPESSYGAEKVVCETLINEYTRRKFITGFTLRFPTISVRPGAPTAAASSFLSGMIREPLDGKECVIPIEDREFKSWLCSPKTLVENLLLTLRLPANSVPAHIRQINVPGICVTVQGMMDALEKVGGKDKLSLLTEKEDLALVPILKSWPTQFDNSQAIALGFKRDDSFEQTVRDYKATLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNR9</accession>
    <name>A0A1Q5UNR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000119">
        <property type="protein sequence ID" value="OKP14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="80" mass="9077" checksum="35FC8484C5DF9DF5" modified="2017-04-12" version="1">MSIGNTFPPMHRDRSNFVPDSLRLSIGKESFLICSSHLSPHSAPARKPPDMDQMAPEEERRKHGILRGPKPKNHQTCEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPP7</accession>
    <name>A0A1Q5UPP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="6996" checksum="C21EE80C3F169DEB" modified="2017-04-12" version="1">MKQDPRISAHLGNNGGVSNHKVNAESSQRQDLRMAPSKKPPPSSPLTNINDPYTSRPSTPLSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQB9</accession>
    <name>A0A1Q5UQB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQB9"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="243" mass="27488" checksum="5C62296052F32B73" modified="2017-04-12" version="1">MSFELKKVPVEELHKMIAAERYAFETPLQPIFRLYCPVTNNDPQETIADIAAREQEQAKNPDPNVENIWIKAVTSQDSKTTETLVGGAQWIFISEKSSSLDADVESFSKRHPEGGARLFAAQSYRILRECEERHRLEISGSGPYATLGSFFTLPEYRKLGIGHLLMQWGLEKADEKGLDIWIEAAPPAVPFYERHGFVQKEVTHLQPRRPDGLDEKIAAEWDDTARELLPITTVTMCRLAGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQN4</accession>
    <name>A0A1Q5UQN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">DNA repair protein rad13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_5847</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQN4"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000092">
        <property type="entry name" value="DNA excision repair protein Rad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="825"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="330"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="510"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="637"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1075"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1129" mass="127396" checksum="F934105C4C59BAA1" modified="2017-04-12" version="1">MGVTGLWTVLQPCARPIKLETLNKKRLAVDASIWIYQFLKAVRDKEGNALRNSHIVGFFRRICKLLYFGIKPVFVFDGGAPVLKRQTIAARKKRREGRREDATRTAGKLLAVQMQRTAEEEAESRRRNKKRPQDEEEVVPDAPVYADEALMTEQERQKNRKFKKKDQYHLPNLDVSLEEMGAPNDPRIMSQEELEEYARQFHQGQDINLYDFSKIDFDSPFFLSLPATDRYNILNAARLRSRLRMGYSKEQLDTMFPDRMAFSRFQIERVTERNDLTQRLMNINGMNGEEAFYKSGQRIAGERGREYVLVKDSQNEGGWVLGVVGNKDAGQEDKPIDVDQYGLPDPISDSDEVSDDDEFEDVPIEGVNRLPKLPFLQEGVFDTSLQQAQEDRDLQKAIFESRRNPPTASNRKADENALFVQDDQDILSQSRRQDSDIFEEDEQDELARALALSMQTNEDADEDMPDISLNRPLQAITAPEPLPEPTFDESDDDMDFSAAVAQTKVSEKKSLIENPFSGPLPFESITLNKATKKPDEPPELDEDAGGFVKEPAKKKKKKTEPLPPWFFGDKLSEEFISEPIFENDSKDQNDAHQDHLFLSNRRSPDIIEVDDTPEVKEVIDLDEDSEKIPEAPMPIEAILSEEAETTKPESPPRPSVAAESVENEIIHSALEAKATAGEPHVVTIEEDVKEANVPDQSFQEESSPEPEFEDVVPPSPAPVPTAGPPEITVVTDRYPEPEEELAPPDLLRQDDGDFSDPEDEDLMRQLAAEGEEHVRFAQTLNSDVILNQVDYEKELKQLRNQQRKDRRDADEVTQIMINECQQLLRLFGLPYITAPMEAEAQCAELVTLGLVDGIVTDDSDTFLFGGTRVYKNMFNQSKFVECYLSSDFEKEYALHRRKLISFAHLLGSDYTEGIPGIGPVKALEIITEFSGLEEFREWWTELQMGVNKPDDAHLAFRKKFRKQASKIFLPPSFPDTRVDTAYLEPEVDADPSQFQWGVPDLNGLRQFLMTTIGWSQERTDEVLVPVIRDMNRRAQEGTQSNITQFMQGPLGAGAFAPRVRSGGPSRMEKAFGRLRQEARGEEPAAAPAGADTATEDRAEEGSSSGKRGSKGAKGGASKKRKMGVDSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQV9</accession>
    <name>A0A1Q5UQV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pumilio domain-containing protein P35G2.14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5456</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQV9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQV9"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000339">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="464"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="9">
        <location>
            <begin position="605"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="703"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="740"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="957"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1147"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP14860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1166" mass="125354" checksum="1B48668DC592D454" modified="2017-04-12" version="1">MLPVSRPEGQMSFNYIPTTQSMSGTSTGRSSPSDLAGSGTAKAPFGSSTSIGVSRLGAGSPSHELGTRLYPKRAREIQAQEGLPTSIWGPPTSGHSTPLRENIPESPNQDSFPDLIPTTNGSMTGSGRRARAGTVPSRFPPMGTLNEMDVQQPFMSQTSRPTPSTSPFRPPGVSGIDPSAGIASSAAAPNPTMLSRLRAGSMPQRNSLLGTGGPFGSSVFSSGWSTGRDRATTLTSIRSSEGPASPSHSSFSQDTADVRTLDYLGLAETPQQPRASLARPSMEQLIHHQQQQQASGLPPLLAELAMMKSNNRFRSYSVNAKEKYADDEDLEYESRYSGIPSGTLTPSAAATAAQLAATQAQIHQHNLAVQAFASHASVNRPRARTAGILEAPPQRSSIRNYLATPSRLDNSFTPSDLHISENGEYDDLAEAVQMMHLGAAGGPAVGVRATGELADENNQDGPTRALWIGSIPVSTTVTSLDAIFGMYGKIESTRVLTHKNCGFVNFERIESAVQAKSLLNGKEIFPGAGPVRIGYAKVPGTSAAGTPGANGIQSSPTPDPNFKSSIVSEGIDQANNFGVVPQIPALVDLLPEMLQIVQEFGATEDDSRNINATIQSAIAFQAYEDEIPSDSEPSQTRMFDAPRLRDIRKRIDNGACSIQEIEETASAMLPEIAELASDYLGNTVVQKLFEFCSESTKEQMLSHIAPHLAEIGVHKNGTWAAQKIIDVAKTPAQMKMIVDALRPYTVPLFLDQYGNYVLQCCLRFGAPFNDFIFETMLSRMWEVAQGRFGARAMRACLESHHSTKDQQRALAAAIALHSVQLATNANGALLLTWFLDTCTFPHRRTVLAPRLVPHLVHLCTHKVAYLTVLKVINQRNEAEARDVVLKALFFSPGDEVLEKILSDQSSGATLIFKVLTTPFFDESMRSEVVRNVSKVLTKLKASPSQGYKRLMDEVGLSSRGNGREHHHGRDSSTPEKSQHRQSSRHGSANFPAQPPMERQYSGQFGSNMLGQTPDSRPISSDQNNAPLDGYGANGMNGFGNPLNGLGGINGFQDPNAPLSQQQLQYQAYLAAQARGVSPGGMYQGMPGANFGYPAVSPSVENLRSLQTQLSAAPGAMSPNAMPGQSSYSPQQFSPVVNPAQMYQYPPQFYAQAQPVQGQTGGRRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR98</accession>
    <name>A0A1Q5UR98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UR98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="122"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="250" mass="28225" checksum="E424744F3F1DB9AF" modified="2017-04-12" version="1">MPNKLIKQGYKIFALAERGYIWTFTRSSRFWGIVDLSRWRDISPTSSTVPEMIRRLPGLSGVISQASSYASGQSSDQTCAQTSGQTSGYIESYTFLASATSHAASHATSQSSSQSSGQSSGQTTPYTVYMGSYFSTVGLFKALRDIRCGACGTTRKSSGIPSYLAELKDHIKSIPWEFREKLYQELFQFAAQTPPPPRERSQPIQQIEKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKQTGREEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URH5</accession>
    <name>A0A1Q5URH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translocator protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000028">
        <property type="protein sequence ID" value="OKP15074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URH5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URH5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP15074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="182" mass="19893" checksum="968438F497CB3B52" modified="2017-04-12" version="1">MPWSFALPQAILTSPLLAVATPIAVGTTSALLTNRTKTKETYGKLRQPPFSPPAWLFGPAWTILYGLMGYASHHATVVASQSLLPAVQEANLSAQTLYTTQLGLNFIWMPLFFGLGRPATALGDMALLIGNVTALMVNWWDGDRTAFWLMAPYLGWLGYASYLNAGVGYLNGWTLPRKERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URR9</accession>
    <name>A0A1Q5URR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="510" mass="55813" checksum="CA29411AB268EDBE" modified="2017-04-12" version="1">MHQGRLENEGCPLLPDEDQDQCSNDHGHGTSRKVKSLRDPSPAWIILLWGMFAMSGGTFVVPEFNASLALVCHQRYAPSSSQPNPQTGQLTLMEELELCLGDKNAQADVSRLIVYCQFTAGILSAITAPILGSLSDRIGRKPILALSTTGILLYNVVMLLILRYPDAIDVRWILVGYAIEGLGGTYITAIAASQAYITDLSSPRERATLFSYIQACTSLAQAAGPLIAGILIASINSFEGVYWISFACYLLLTILFIFVLPESRWARSTENPGINLDNPSMTENPLRQVYTSCKSLWESSANRRGNLAILAVIEQFVFGVMTCLPPLQMAYSSYLFHWRPTTQSFYMALVNTWSILVLVVLFPVIMSVVRRQIRRKRNRTHSTVFNTGELGAIRTSLCLQILGYAGVALTRSPEWFIFCSLIFACGNPVTPLLTSSLTAHVPSEHSGHLLGMLSFMHAIGRITIPTALNATYSVTIGVFPQALFVVLAVSVAGLLLSSLCVKSYGLGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNN2</accession>
    <name>A0A1Q5SNN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNN2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="65"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="37719" checksum="F731EEFC8ED9D1F2" modified="2017-04-12" version="1">MLGKIALEEAFALPRFKEKTRWWAGLFATDVDQHVAEINDVDSIRLNFAEKHGVGLQILSYTAPGVQDIWDPVDAQKLAVEINDYIAEKVKAHPDRFAAFATLSMHDPQEAATELRRCVTQYGFLGALVNDTQRAGQDGDDMIFYDNAKWDIFWQTCTELDVPLYLHPRNPTGTIYDKLWADRKWLVGPPLSFAHGVSLHTLGMVTNGVFDRHPKLQIILGHLGEHIPFDMWRINHWFEDRKKLLGLTETCKKTIREYFAENIWITTSGHFTEVGADRILFSIDYPFETFGDACGWFDGMEMNESDRLKIGRENAKKLFKLGEYKDCNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP30</accession>
    <name>A0A1Q5SP30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_13786</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SP30"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="189"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO89720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="54153" checksum="1E9820C84D95B67B" modified="2017-04-12" version="1">MLDLNDFIAERGGNPNKIKESQRKRHAPEEAVDEVIALYEEARKARYEVTQFGSQLNPLLKQIGMKKKNKEDASELMAQKDELEKRKKAAEDAAVQKELERDRKIRTIGNYVHESVPVSNNEDDNEVIKTWTPTDAVMERPNCLSHHEVLTRLDGYDPERGVKIVGHRGYCLTGYGLFLNLALVNYGLEFLFNKGYTPNQPPQFMLKDLMAKTAQLEQFDEELYKVTESEDKSTDKYLIATSEQPLSALHDSEWLQEKDLPIKYAGYSTCYRKEAGAHGKDAWGIFRVHQFEKIEQFVLTKPEDSWQAFEDMMATSEEFYQSLKLPYHVVAIVSGALNNAASKKYDLEAWFPFQQEYKELVSCSNCLDYQSRALEIRYGVKKATDLKKTYVHALNATLCATERTLCCVLENYQREDGIEVPEVLRKYIPGAPEFLPYVKELPKSSTSQQKAKKQANKPAAGAEDAAKKMQGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQQ3</accession>
    <name>A0A1Q5SQQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional regulator ADR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQQ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQQ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO90300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="771" mass="86491" checksum="58CAEF41CE0CC46F" modified="2017-04-12" version="1">MLSNSSPSNPHLTGLKARRRRKTSKEERICPVCAQTFKKAEHLARHLRSHTKEKPFNCPVCNKAFARQDTLLRHSRSHPAGSNAYTSTAGMYRAIDESMDESMDEEHQEYNVNPELISQAIGSEIPAVPLHLDHLNPMAGNMMAPVSPPNSSSIDKHTPNMSIGETSTYPTQVTPLTSLFSLETGDAWRNQASPQNPMWDYLLDREWETLLTGEDFDLDAVNTSLLYATSDYVPVDTIPGMDITRLLPSVQTASMNSDSAKQHADTVQKKWHTYSELASSGQMTPDVPREASFIDEAYRKRLADRLQQRDLCIQAYFSKFHPLFPVVHMPTFRPGTQNAVLLLSVCSAGSLFVASSRAISHGISMFERLNKAILASWARKARIFDLRHSTYNLLDLDGQALEDAWLRWVQVEVKKRIVLGLYIHDAELAHLHHHEPILRHSPDRLPQISSNELFTASSAEHWKYLMLDEQARTLTNNPPHNSPPSQQNHRPQGVLPSDFALVGMLESISAMAYEVHDQTTLQNPWDPTSTSTLPPPSSSSTPPTTQCHTLLATWYTTYQPTRHSKPSWPCLMMLWHSIYITLHADINALECAAGREGYDAVQKYTPYARAWVRSADAKRCLLHALLIQKNFESLSAGAEPGMFVPKCLYYCGLVWACFMCFGGDSQSREGEVEPEKDNENKLNPGDSEGQRENGCITIGPAENLQFAELRLPGVDGIGVFLEQMGGLQPRRLAVGSLFRIIDLLQRISHWKIAQSLAMTLLVVVEETQDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRD1</accession>
    <name>A0A1Q5SRD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRD1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="118" mass="13413" checksum="1EF55BA6F8137559" modified="2017-04-12" version="1">MFRCNGALRTLEAYVPSGAGALDWHAIGIRRDPRTGEMEWGLGSKEAERVEVYQRYERGEPGEGFLLGSQGRTNWIVRHSGSSLNSLDHQPFWSLRLMGSDTKRRAGEYETRIRINSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRZ1</accession>
    <name>A0A1Q5SRZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012592435" evidence="7">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO90635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="14298" checksum="712BDCEBB7A0EF22" modified="2017-04-12" version="1">MLSVLLISIALFGTATAVVITYRRIIKELVDKRSATYSNRPASYVSHDLMTSEDHLLVMQYGQQWWSFRKIIHQYFMESMVERHHVEIQNAEAVQMLRDMCVRPDQHMRHPKRFSNSIIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5STX9</accession>
    <name>A0A1Q5STX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-ascorbate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000747">
        <property type="protein sequence ID" value="OKO91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5STX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5STX9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13895">
        <property type="entry name" value="CuRO_3_AAO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035666">
        <property type="entry name" value="MCO_CuRO_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="175"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="38900" checksum="F2B8060BBF6BF226" modified="2017-04-12" version="1">MADSCGSLFDYEVKLEIGTAGTYFYHSHVGFQAVTAKGPLIVDSNDDPPFRYHQERTIMLSDFFNETDKKIIDGLTSSPFKWSGETSAILVNGQSHQATNSTGSCQLASICIEPDHHHAFPTLNEVTRRIKIDVHQNVSDHVIWLQNGYDWVQSFPQSPYLVDIYTGMLDTDGVYRRAISQGHGFDNITRTFPAQIGEVLEIVWQNQGTFSNGGLDARPFHAHGRHFYDIGGGDGEYNATANEERLKSSGPVQRDTSMLYRYREKTTPLAPSGWRAWRVRVTEAGVWMFHCHVLQHMVMGMQTVFIFGNRNDVMAQSDPVDAGYLTYGGSAYGNTTHSPVVRHYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUW9</accession>
    <name>A0A1Q5SUW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUW9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11155" checksum="895BF1EBE25A715E" modified="2017-04-12" version="1">MAQFLREQEVISADIIAIQEPWENPFQDNTHNPLKQTPELLFPPAIETGQHGERVYFISTTLSRHTHLVHYRDCQGVRIKTELSRQLRIINVYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SVC8</accession>
    <name>A0A1Q5SVC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SVC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="20744" checksum="81543B4782A27828" modified="2017-04-12" version="1">MLFGLLPLVLPATAYTPVIVVETSEVTVTPTDVVVKTATSTPTDEPALPTATSEGILTVSLLYPSWLKSILATAIPSTWEERLKTDAAFEEAEYERESEGIMPAWYSRLPSDAKYALSSEKAVEPSEIVANRGYYYCFPICHLLVNNCDYGGHCVRISDAKSKIAGTSTSTGGAPGATGGLVAGIAGAAGILGLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXA4</accession>
    <name>A0A1Q5SXA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent 2,4-dichlorophenoxyacetate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXA4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXA4"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO92613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="323" mass="36449" checksum="E6283D02B816D1B8" modified="2017-04-12" version="1">MSTTITQTVNAGGPTPSLTVIKNGFGAEITGLDFVNGVTDEEYRFLEYAVKKHGFAVVRKTKLVDETHLELARKFGELDDVTPYNKAGRVHRLKYNELFDVGNIDPDGSIVDLSSPRGEANKGNSLFHTDSSFNPRRAGYSLLLAHELPPPGTGGSTAFTDMRAAYRDLDPEFKQFLREKKFIARHSLLHSKKMAAPECYKDIEPTDHFMSRHLLLQVHERTGIPTIYLAKHIHSLEGVSSEESEAILNKLFDHATQDKYVVDVQWYDPGDMIVWDNTCTMHRAVSGEFVTTYRRDMRRATVHDDSSLAWGFNEKSNKRMGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXE2</accession>
    <name>A0A1Q5SXE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO92688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="279" mass="31923" checksum="25D851C24DBB2961" modified="2017-04-12" version="1">MIEASPECKYFGPDIKFTIQASCGPLLEMCEDGVIQIIHHSLTEFILNFNVEHIGMNQKSRDFAIVDSQAVHRKIARTCINYLTSGCFKTWQFAEFRDHEPEERQSLFLQFYFLRYAILEWPFHVAKAGDDRELLDKLGEFCRDGNHHYEAWNDIWRACQGEDVPRHCSALHVSAYTGLYTLTQYLLSQGSDPDSKDEDGRTPIVYAIMKGRHEIVSLLLRNNASHDVKVETYLHPTKINSLIHYACKLKHVQALCALLDGGMSPVVKDDGLSTSGKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXX5</accession>
    <name>A0A1Q5SXX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_12787</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXX5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000007">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="683"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO92802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119326" checksum="109AC6E92EC28D68" modified="2017-04-12" version="1">MFRNTALKATHSNMLRGVASSTSRRAFHLTSTARSASKTSTFGLTSRRPLAVVDRAFNGARLYASSAEGNAPGVDPNDSFLQGSTANYIDEMYLAWKRDPSSVHISWQTYFKNMEDGNMPISQAFTPPPTLVPTPTGGVPQDMPGHGLSAGADVTNHLKVQLLCRAYQARGHHKAKIDPLGIRGDAEAFGYSKPKELELDHYGFTERDLDQEFALGPGILPRFLTETRKKMTLREIIAACEKIYCGSYGVEYIHIPDRKPCEWIRDRFEIPEPYNYSVDDKRRILDRLIWSSSFESFLATKFPNDKRFGLEGCETLVPGMKALIDRSVDYGIKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGSTEPSDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRAIQHYNNDETKFDSAMGVLLHGDAAFAAQGVVYETMGFHSLPAYSTGGTIHIVVNNQIGFTTDPRFARSTPYCSDIAKSIDAPVFHVNADDVEAVNYVCQVAADWRAEFKSDVVVDIVCYRKQGHNETDQPSFTQPLMYKRIASQKAQLDKYIEKLINEGTFTKEDIDEHKKWVWGMLNDSFDRSKDYQPTGKEWLTSAWNNFKTPKELATEVLPHLETAVETKSLQHIADKVSGSSVPEGFTLHRNLKRILANRKKSVDEGKNIDWATAEALAFGSLVDEGYHVRISGQDVERGTFSQRHAVLHDQETEATYTPLQNITDKQGSFVISNSSLSEFGTLGFEYGYSLTSPEALVMWEAQFGDFANNAQCIIDQFIAAGESKWLQRSGLVVSLPHGYDGQGPEHSSGRMERWLQLCNEEPRVFPSADKLDRQHQDCNMQIVYMTEPSNIFHVLRRQMHRQFRKPLVIFFSKALLRHPIARSDLEAFTGDSHFQWIIRDPAHKTEAIEAPEKIERVIMCSGQVYAALVKHREANGIRNTAITRVEQLHPFPWDQLKENLDSYPNAKDIVWCQEEPLNAGAWSYVQPRIETMLNSTEHHNRRHVLYAGRAPSASVATGLKAVHLKEEQEFLEDAFSVHQDRLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYE2</accession>
    <name>A0A1Q5SYE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000734">
        <property type="protein sequence ID" value="OKO92970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SYE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="90974" checksum="EC6AEAFE17E2348F" modified="2017-04-12" version="1">MSIKVKEVPVEAHNSVGKVERYHAPLRRAYEILREELKNENIDREMILQMAVKAVNDSAGPDGIVPTLLVFGAYPRMTEMDPPSPSVVKRAEAIRAATKEVRRLHAERQVNDALAMRNGPNITTTLDLPLQSDVRVWREKGGWKGPYKLLAMDGEICTVDMPYGPTKFRSTVVKPYHREELPEGEGEQRRIRAEDDQVDRTVDSEPVNEPDKPVEIQRRGRGRPPGSKNKPKPQTTVRRSTRGNPTHHQDLEDQFINTIWEGQDVAMALMTNKERADMELSIKLRNDGVITTPGLPFDQSRNEEIEGLIARGVFDFVRYDPVKHAGIRIFNSRLVNEIKGKATGTPFEKSRLVIQAYNDEGKGMILTQSPTIQRASQRVIVALAPSLSEKNISLSIRDITQAYVQSTTSLNRLILAHLPKEIKSKFSAGTIMVVRKPLYGIPEAGTHWWATYHKHHREKLEMVTSPYDPCLLISTAKEAFGVVGMQTDDTLILGSDEFAKLEAKELAEAKFSAKPKDTLSPENPLIFNGCVLTQKEGDVAVELRQKEQGKKLKLIDHKSKDLKQAYMEQRARGAYIATICQPEAAFDLSVAAQHQDPTEADVNALNKRIIWQMKNLDRGIKYVAVDLPTAKHFVFVDGSFANNKDFSSQIGYEIILANESAQNEEFEITGNLIHWSSTKSKRVTRSVLASEIYGMVGGVDMAIAIGTTIKMIMDQLGFEKIPTIVCTDSYSLYECLVKLGTTKEKRLMIDIMALRQSYERREIMEIRWINGSDNPADAMTKADPNTALEKFITTNTLRVRVEGWVERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SYP6</accession>
    <name>A0A1Q5SYP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000729">
        <property type="protein sequence ID" value="OKO93072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SYP6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="11160" checksum="62A2E663230EBB6B" modified="2017-04-12" version="1">MAPGSDTRGWLNPHQHELLHESGNNTNGQNTIGIIVFDRESVQAQSIEKIPDKNELLERDFYGMVEKRGKAFRIRVVRHLVLLKSRQQNGSRQTPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ54</accession>
    <name>A0A1Q5SZ54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ54"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ54"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8836" checksum="C485E427CD5C91FF" modified="2017-04-12" version="1">MEVLITHGDADMVSMGLRHGKPMVTFPVIRDQPFWANAVSEVSAGPLPIHEKDLFSETITPAIRHCMQPETQQVCNHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZB6</accession>
    <name>A0A1Q5SZB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZB6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZB6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="14408" checksum="28F278D862C370B1" modified="2017-04-12" version="1">MERSNYFVEIKRPDENLIEILYRPKGLCEKDLSDPSPEEIIIRRERQTFRRMPKTGTILFGVKTYLTTLDQLPMQELENLAKEMRSWPEYVGEYKGKDVWGAKVLEFYKSRVGQMDEKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2T3</accession>
    <name>A0A1Q5T2T3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisomal membrane protein PEX30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2T3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2T3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="300"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="587" mass="65178" checksum="5A1F7264CCDF5977" modified="2017-04-12" version="1">MSMAPASQPQDGQADSSLPPTIAAFSPSTIAGSASTSRQRSSIIVHRKSPLLVATPPAITRALAYSHPFLLPLNKLVGLLTWTTGDPWQSFLLVATFWTVVLYSDAIILYAGPILVVVGLILGMYGRRYSPLSSTTSTGEKHRRKASAEVTRHQKSLDDIVETLRTLTTRCHILLEPLLDLTDFLSTQRTPTSATTRPALTALFIRILLVTPVWIILTLPPFYIITTRRVVMCVGTIILTYHSRPARVSRVILWRSRAVRRLVSIITGLSVADGPHTPQKSAVQGMGLNISTRRRGNGSGVRFTFVVYENQRRWLGIGWTYSLFPAERGPWTDEHLNTVLPKDKFELPDVQTGDAKWRWVEGSEWRVEGGDNSGNGKSDSKGPSEGWIYYDNKWNDGRRGQDGWDRYTRRRKWYRDAELVDTQQDGPSEAVSSLTQALEREKEQEKDKKDSDPETNSLSPHTPLKARRRRWFGSKDSSKESSKERTSSGGSIDAGRTTSANFSDATGGAGSGRGTPARPVSIQNTRRQSQYSVREGSMATSDSASTREKEMASSHDRHDKWSTRAAGGTERAEREMGLSDEVQMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T304</accession>
    <name>A0A1Q5T304_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T304"/>
    <dbReference type="OrthoDB" id="5429002at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841059" evidence="2">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="169" mass="15845" checksum="638F2ED136A2F89A" modified="2017-04-12" version="1">MRASFIVASLSALAMGAIAADSSSSTEGNPATKYLTETNSLGVVTGQPDAVTSQPAAVTTQPAVVTSQQPAASIPAGLTSPVVTPVTNSASSSGSASTSTSKSGFTSSTKSSGTSTETSTSTKTGSSSSSSSGSSSSTASSSSSTGGAAMATAGPMGLAGLAALAAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5U7</accession>
    <name>A0A1Q5T5U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5U7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5U7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="345" mass="38996" checksum="2F24C542465FDDBD" modified="2017-04-12" version="1">MGSVPRKDVAPEDQLADEQESLGLEPAYKPVTPSPNFDPPFRNDVRLVQRGFLKGVMHFVNKNTDNLSRSIFDRLVSPVKFANCVNNYSELRQRHRRLIELEDAEYKAERVRFVNYYTTSTGRKPRKTKGETDKDTSNKLEETTADEPAEKEVSEELTEMLAEKIKLSDDLELTPPPPPTRKPPEVPTVLTSEAAPSTARISPPDNQSLKSVSSDSTLAAPEMSPEASRPSIETPSLASSTTLDPESEKLSESVSISTSQSDLNPDTSKRKLRKFILLPSHHWKYNDNSHWTPILMEDMNEVTAHQSMFVPQGANYDYLVGDTVALIEQWIQTDLSQRLMQERFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T654</accession>
    <name>A0A1Q5T654_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0589 protein C32H8.01c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T654"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO95701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="16588" checksum="545824B266CE9579" modified="2017-04-12" version="1">MSLTNVYHLRRVADTSARACLICYKPSTSVMITPDNKDFFYVCPAHLQDRHFCSPIVDAEGEAARLKEQQMAEEIEKVKKEYEEKQKRKKEREKQSSKDVKDKEKDKKKDKDDSKDKDSADSKTNDEKERDEKVSPEAIIMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T848</accession>
    <name>A0A1Q5T848_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T848"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T848"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="36102" checksum="E065EBF11C742820" modified="2017-04-12" version="1">MTGQLIFITGATGFIGSATALAALKAGYRLRVAVRKPSEKLQALVSEYGQQVEYVTVPDLTDEAAFHGKLDGVDYVLHLASPLPGGTDKKDYFVPAVKGTTALLKEADRVASIRKVVVTSSVVSFIPINGLPEGGVIKEDNDWDFSVDEDASFEDPKNPGRTPFTLYHASKLLSNNATWSFWEKAKPHYSLVSIHPTYVIGHNLVQSSSKDFGSNGILWGPIMTGTLSGPSFGVHIEDVAEAHIKALDPRIPDGSKYLVDGDRITWKEVAQIVHRDYPNVGAKISLEAEGGAPPVDTSKAEKELGMKWRSWEQMIHELMDQQLSFVNKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8D2</accession>
    <name>A0A1Q5T8D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetracenomycin polyketide synthesis hydroxylase TcmG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8D2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8D2"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013135459" evidence="6">
        <location>
            <begin position="23"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="59335" checksum="057B4497BDAF942A" modified="2017-04-12" version="1">MIPSTNHPVIVVGASLVGLSAALCLASHQVPTIVLEKHSGKSQHPRAIGFTSRTMEIYRILGIENKDPAPEDFKLERAHVESLTGKWLDESSWSDTERKPKVEKPVKPNPRSSGPKKEYSVERASAIPQDKLEPMLEALALERGADIRRQQKLIRVDQDQDGVVATVTDAEGNEQKIRGSYLIAADGNRSTVRELLQIPRHGRGHMQTLSSVLFRAPIEQWTKGFFQFDIGQPDLKAFLASYSDGRWALMFKDAIDRDEQALRAAIYQAVGRSDFPVEIITTGRWELTALVADTFQSGRIFLAGDAAHTLPPNRGGYGANTGIHDVQNLAWKLAAVLSGKASAKLLDTYDSERRPVALLRHDQIFVRADYKIHLDTATPAGEKIDDDAMEFGQIYLSEGIIGADKSLPRAKKPDEWNGQPGTHMPHFWVLKNGEKIPTLDLLGQGAWTLISESDKWSEAVSTVNESSSIPLEFVHFGNSVQLVHGDDFQKHFSVSQSGAALVRPDGYIAWRVEALPSNAAEALKGVMSKVSFSTGGPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9N1</accession>
    <name>A0A1Q5T9N1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_10422</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9N1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9N1"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="986"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="986"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO96868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121890" checksum="DA750F2B4C61C1E0" modified="2017-04-12" version="1">MDQGRSTGAQQPDGLRERNVPRPNSTGAGDALTATGELEAKDEAGKDKKTFGRTPDGTVFTVPQTHDMVSQLLSPSEPKNVGDLVVIALLAIHILLLWYLPASVKVPILGFIYLFWRAAYNGGIGWLLHNQSHHKTLIRWAEKTKVFVNPATGQNPHPALYNWIKKELETKIPKDYSFDNAPLEYNTWLVFRRLVDLILMCDFTSYCLFAIACGHRPVDESIIMTILRWTAGIVLVLFNLWVKLDAHRVVKDYAWYWGDFFYLIDQELTFDGVFEMAPHPMYSVGYAGYYGISLMAASYKVLFISIIAHAAQFAFLILVENPHIDKTYNAPPPRKRSVWVDSTSSLPLDPDTPRAPTPSDDFAPNASSSYSAKPPPSVHNLLGLHNLDLYRTTDSSIMLVQLLVFAVTALTPSTLRYQLLFVANAVAWRLWYSVGIGYLLNKQSRNKAWTRHFLKFGETPQEAWNQWKGTYHLSMIMCYSSFIAAAWKMYTFPTDWGYGLVLFRHVLGAGLISLQIWTSVSIYDSLGEFGWFYGDFFFDESPKLTYDGIYRFLNNPERVLGLAGVWGAVLITSSATVTFLALMSHILSLSFIQFVERPHMQKLYGRSLRRDGGVVKNLKKSLPPSLKQLHGSVDKIFDDSFEFIEELLDNARPKLAAGVNTFVKDTTALFQKYPARITISRIDADLAGLNVSDYSLSVEGTEAKSLEETEQGKGREGANARMPLDRRGDLKNLTFEYGAPIKVKWTAPLNHSKKDWVGLYRVTDNTSREVTRVSSQGRWVATNEGFFDNTTCEKGIITSDTVIRSAEQNGREGHDVASGEIVFSGDKLFWTQGTFELRYHHNGLHNVMAISRPFEIRIRRFAEDDVVVDSDGIVQTAVENALLPVVRNCFDRDPEIAPENVEEQFGSLVERDGKFAKRVVFAVHQMFGVELAPEVVKADGNVLNLAWRICNAKKVLYWDLDFKIVSMDSKTSSDARGKNSSILQAKNAKANNQSSQFNSSHPLLTSRARLSSKTDKHPDPKEPTQVKHSRATLKAAEPDDDLAYARRFSTTFLPVAPVRVQEVQYLGVGERRSTPRPESTATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9P2</accession>
    <name>A0A1Q5T9P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9P2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="16103" checksum="C5AED9FBB0DAC8B7" modified="2017-04-12" version="1">MFSDDFDTPVVDLNQIAVALSYAPPTLTEINISADCQTDVMVYPGLSTKGSLQTLSNLHSVKSLQIPLVFLVGFAQDTTKLLQDKMPRNIEHLTLGYDLSEFYNTLSEKYPDWEWEDSAVFGLLKSWLEDWNSWTPCLRGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAW1</accession>
    <name>A0A1Q5TAW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAW1"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="8939" checksum="1AC58172A387E941" modified="2017-04-12" version="1">MVLAVDLLNPTPQAEARKHKLKTLVPQPRSFFMDVKCPGCFTITTVFSHAQTVVICAGCSTVLCQPTGGKARLTEGCSFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAW2</accession>
    <name>A0A1Q5TAW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAW2"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="36764" checksum="B932226228FC7257" modified="2017-04-12" version="1">MPSQPPLPPLLTSYLSDQRESSLTLVSSILGATSNWLVLRYLYAALGTSSSSNISIGTDELSNGAKRKVVLVSFLRGWEFWRAEAKRLGLDLARLADKQQFAFVDGLSELFNSSSSASSAPINTGSTVRTTLPLRSQPGAVPGRGPPSAVTPGRPGTESLRQREPGAVKKLHFTGHGIAALDAMEKDVISEINRQKSSMTDGDEMLLILDQPDFLLAATGASMGVGATEMAEWVTGLQQQVHATVLTMAADSPLIHNASTSGNQLSTPIETEHAAFAIGMAHRAWSVMQLRTLETGAARDVSGVLRISRGGGWTAEAEDNLGERELLYYIQRDGGVRVFGRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBX5</accession>
    <name>A0A1Q5TBX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000686">
        <property type="protein sequence ID" value="OKO97726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010348370" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="242" mass="27444" checksum="29511F6BD44CFFAE" modified="2017-04-12" version="1">MRPFAAVLAISLLAAPAAADWELYTSTCYGFSGSYMISGGAFNGDPCSTDKGAHWDNNYRERRMDSYNPCNREGKKLRYVRDGSDYNVYWEDSPNNKIGRCYEKIDPDRTAEGEIKFMRQIGQRLRYLPHSINLKPYPGDILVSWEDNETESVRTLGPSRPDYHVVLHDDNCASAETVLLHDKAQQNQLISMSMSSGEEARRARGKKDIELPSERIANNPNIDQVISSGSEAQRKRKLNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC92</accession>
    <name>A0A1Q5TC92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC92"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC92"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF79">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="897"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="902"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120076" checksum="0057B2A3860A6E57" modified="2017-04-12" version="1">MDFSPPNAQTLPSVSSSGRAPSSARGPLAGGRQITRNRASYSCHTCRRRKVKCDKVHPICSNCAKSGAECIYDAAPSSQRTESAREGSARPGYGVKRRRETPRTLEEDVDELQSIYGQLREEDSPGDQKGNPRAIEARLDKLMSMIERLGGNPHALEEAERQGVAPTGGMETALLEQLRQSSRTQNGQSASSRRSSPRRTAAESSGDEFPIPSGQATDLVDPINDLNQLLRDQNRSHDVSSENANEDSSNPVTGSRRPWKESIDSSANSTTSRSRVGSFQQSIIFPSGDSPSVNEKTVEPEMLEHVPTRRQSHLLYKGFMSGVHAISPVLHPPTILKLYNAFWDWYDYTSYSGEPCPNPSFIPLLYAIWYGGSVTISIRTIKAEFNASSRVSLSTMYSEEVTRWLTKISFPRSPSLQGLAAYLIVQTILSKEEEPLTSSLFVSLAMRVAQTMGLHRDPANFGIEPREAEYRRRLWWHIMHMDGVVAMSSGLPPLVSDENYWDVRETSEIKDTLLGTQTAVQYEQLLAAKQRLPDNPDDPSVCGGPSMVNVFYLTARGKYTMARAVRQILKIQLGTKPVTRSDMEELRTILLGLQLKLNSIVNRIPEGLPTGSPPVSTGRALSMSKSPVEARATETELPGEGPNGCPEQYHTPVLVSFHKWARIILSLYIDKAFCVAYQPFLKNARSRIWPAARQSALRHCHGFMEKFIQLATDPDFQPFQWSWPGNHQPMHATMIMLIDLYERPYSPEASRSRAFIDRILALSGPDGGVVGGEDGISTQRPLKDGGREAWDMIRRLRQKAWQKAGLNPQMLWTEQDQIQAGIASPAGEVRGSRVPFYSGTSSVPGSPGMSTTMPSRQPAAPDRQLTDFNRMFYNMTRSHMLPSPAVSSASVKPSPLRYSYELPPPNRTSAPLPTPQYNPTPAAVTLPPTDILPAPAPIATSPQMTQSLGSPPSPHSRAPPSTAPISRPEQSLPNITTSPAMPFMDPISSNPPPIGVPTPPSMVDPNLNFDWDQWDAVFGQHLPVADELMELDPVSGLDFANLGFPAANNDAGVRFNDLPDSLSSSNGNLPPAWADTCSGNPRVPSSDWTGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCJ7</accession>
    <name>A0A1Q5TCJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TCJ7"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1600"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2531" mass="285306" checksum="5487917FCCC2D31B" modified="2017-04-12" version="1">MVGSPPASYRTPPGAPLIDPTRPQNDPMEEPDPERVQKRPRLDSGSGVSPLISIDAAAVPPSASAPASAVATPPPVPSLEMDTTPDQTRPAKVTINVKSPTLETDIANGMRDPSPVPDGTPTRPDSTDPNEAASDVISISSSPAHSPEIQAGDPEDMDENWQRLEDAIQEEEVVEVEDLASPLVDSFPRVRENLSTRDNLVRIVALIQKAGPRDAEAASAVKTWMDDCVKNLDRLTLEEFGEDQEFWQQFPDVVESLLRRSYELLIDDGSGSGPWTCLEEFLLDYVQIALQVMRIDTVILRHLVDDPELPVQDSICKDYLQALTFVFLSPKSPIPLYRALDKKYPTDTNDMLVRIRAKALAPPIDLVHTLSQWTALTLELIPRHPHLTSSLGHIMLIANALADCHLERQSDVNVDDIDSPLPDTPPIRALYEMVRSIDEKYQEWISKKAAWATSDLSEQLMRAISHHYKHHCARNSEFVNQLAKDLSILLPENTSQAENSLILFWMWKLAVLKKHIMEGRMELRVYGVETMQSDLVHVWRTSISSNPEGVNLPFVKALVRFIKNNKIVDYLVGVDSHPQLISRSSNIIGFLIVTDTYNDSVTNVIWKTVTDSQDGRIVSEVLAMLVRTFNMHLTGSHYLLYVCQKVLDLPLSRFDTNMLEFCNKLLARICENPPDRRISGVSDHDCIDARPVQLCVRLIRDSTAADDLSVEQKKSLQKFGSQRLMGFVAAGISQADRMAIYMRCITDIAGHNQFTAGSIQTLSALVPAHDVQEMLKLARDFSLTALVIGDMLHAIKVHNDTSTDEFFQIGLVSRLTIIFRLIDMVPETITPELGKALWDDILLSKKLRTDERQAMWHMLVNALGQCTEANPFLHKCIHEYLPSLAPKDYTNEILSFAKQAMIYEVRFNPPPPAGEDEVVTIPGMDRFWTFILTAPPGTIEVQATEFAVKVYLDHAIITHSPRSAIEATHISLVERCVDQLKSAAAILKATSEANGDSSMESETETGDMSPEELRFRRSLYFLHQLLSGLRARPHYNSPRGSPPVLPERPIRGDPINISWQSFNGSESSKVKNLQIGDLSTAGELVERLTQLTGFSKFTSIAGGQRVDLMKDPETTVRDMKVLHAGLLLVRKAPDAKEVFYASSGGQPLTSVDSEVLKHFDELYDLLTLNDDLAREIYEFLVTFSPQPRVRNLVKSDTSTAKDLFPFDKPFVAFYSFSALLACLIEEALEDTHNQTFIAHSIELLLTFLMADELVESLTRDRNRLHLASTAVECLLDAVALYKATDSGNLVAQGQTPFVRRLLHFIEAARSVTTKPSVNMLTIQKLVCNSFGVLVEGSIRDQTFWSAVKQQTQLGSLIKALLLEETRQPIRSDVSERIRRTCSSAKSMKQSSKLANGNSPILSTLNSPAQIDMLAAVWNAFVETIPMTPEYASQSAEFFNVALGVFRSVAEKSPRDVIFSQYLKQWSEIMLQHETEEFIGREPVDSLVLGFAGLLEQCLESADAANVDLETFDLAEQIISKYLFPELANETDEVIVPRTPHMHTETRQKLYNILRLLCKRNDENVARIMQHLEGVIPRDESYSPTWCHDRSKMIRAPEGYAGLRNLSNTCYLNSLMTQLFMNSEFRKFLLGLSILDPNESQKLLDETQKLFAWMQDTWMKSVDPEGFVESIRTYDNEAIDVTIQMDVDEFYNLLFDRWEAQIMDPEEKKKFRSFYGGQLVQQIKSKECSHISEREEPFSAIQCDIKGKASLDKSLQAYVEGEIMQGDNKYFCSGCGRHVDAVKRACLKDVPDNLIFHLKRFDFDMVTMMRSKINDKFQFPRLIDMTPYKVEHLSEPSTPVDPDVFELVGVLVHTGTAESGHYYSYTRERSSSGSAPIWVEFNDSDVSKFDPTTIADHCFGGQTEAGHNMGGVQINKVWNAYMLFYQRVSTMEQTKQVSQPMKPSYPARVPVPTAFANHIAMDNELFIRTYCLLEPAYMKLVPELLYRVRQMNPNSAAHHQLQVMAIELGLDTLEQLIARTKEPIGLLGVYEELRTLIQSPHGALRALHWFARWPTTMRNLVLRIFQYDVRQKEMSIILEAVRCLKICLQGAGMDDETRATWQQELEETLDTIVSMLADLWPALHTIPRVWDEYFEFLIKLIELGEEATNAMLANGMLVKCLEIIWLDSEDRKNLKGRYPGYCRLLEKGRQFPYRNLMTFCAMLFQRVDLSLAPSAPNDPREFGRDGRPSLTAAENRFIKPLEFQKPEDENGVLVFLMKLLQHDQICVQAEVSRAIVAAFLAAGPEAGFAPHVLRTLEVGLRFSPVELCIPFLECAVTFCKYASDEDAIVGLISYVAKGVDSINNSAGNEHLEFFTQLCNVNNEQLGLDPDWFIEAVQDRIPDFVPTLLIYNHPNVRRRTTEVLRGLLFIGDKDEMIEEARTRLARIARELTHACVQRIASAFLNSQVHSVESRIVYPITSTVTHCLETYFDEDDEDDQRDIERANTILLRLQEMTVDVPDDLVSDSDIASPEEWEATSALASDSEMGLAGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD51</accession>
    <name>A0A1Q5TD51_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD51"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="146" mass="15848" checksum="108F5CD5BA58EE35" modified="2017-04-12" version="1">MEKNQQADFGASLIVVPAKVILNGYTRLTTILVANSRSGFSGETPSTSRIPSESKDYQKLQGLDEKDAKTAYTLVITTYDTMRRRTIKAVGPDGEDMDPKKAPNPKTSNASDWKTSRKSNHATSTSKEGLALGVPQIVLAQMEGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDH1</accession>
    <name>A0A1Q5TDH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CDP-diacylglycerol diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDH1"/>
    <dbReference type="OrthoDB" id="4932058at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.30">
        <property type="entry name" value="HIT family - CDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012366519" description="CDP-diacylglycerol diphosphatase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31322" checksum="D67FF8378521EF98" modified="2017-04-12" version="1">MKAIQATPIFYFFLGLLLTVSSRAQEPIADSDRSSVGTGQICKYNQISSMNVQFCQCDQLKRPECRHCDLNNCKTKSHTHSGLTYCGLGCIDDNSECDACYLWFQKLCLCLQHGCPTRKASSGNFDWVLMDDNLITATQLIPGIRELYVEDPWTWGQQLWKPGKGALAINSVRTRSQEQIHMHICRAHDETQKFLGQLDFTQYLKAMTEVTEKKWMCQAGETGATSMDGIVAKVQGQLANDRWCPNFIGAAMIADSKGRIWACVTTEESETTEFSFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDT7</accession>
    <name>A0A1Q5TDT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_9478</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDT7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDT7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="381"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="481"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO98380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="659" mass="72351" checksum="058E82689B243909" modified="2017-04-12" version="1">MFRAQQNAFDDAVAKATDENLTSENWEYILDVCDKVAAEESGAKEAVAAMIKRLAHRNANVQLYTLELGNSLSQNCGPKIHRELASRSFTDALLRLAADRNTHQQVKSKILERMQDWTEMFSSNPDFGIMEQAYMKLKTQNPNLQPPSKPVKSAMTDVDRQKEEEELQMALALSIKDKNPPPGPAPQAESSSAAAASSSASAPAPTNTADAAISQPVPSGTSAATVSRVRALFDFQPSEPGELQFRKGDIIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLPDPTVEELHREAQMEGEVFGQIKNVEKLLTLLSTRSSDLNVQENEEITTLYHSTLAIRPKLIELIGKYSQKKDEFTQLNEKFIKARRDYESLLEASMAHPPQAQYGRPGQPPYGYPAAAPVGYPQGPPQGAPQPDQRYFSPRPQGLLVPPPGLVEHPLIEVLDTPTPQSQPNAYYGAEQSMPYRPASHSPDPRSQYPGGAQPLAQPLVQQQTPQPDSYQPVHHRPQSTYDSPQELGTSVYDSPVDHPAAANQRPPYPASGQAPPTAHQQFQQQQQQQQQQQQDYSPSVYSTDDPSASGMHQQSPHQFPPQQQQAQQAPYPTSPPAHQPPPIPGAAPASQPAQYTAFNPAPSAPPTGEYQAYQPSQAGVPASNPASFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDU8</accession>
    <name>A0A1Q5TDU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDU8"/>
    <dbReference type="OrthoDB" id="4327660at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF3">
        <property type="entry name" value="ANTIGENIC CELL WALL GALACTOMANNOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010184872" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="199" mass="22036" checksum="BF8EB3CADEA4713C" modified="2017-04-12" version="1">MRVLKTLVTFCSLFLVASAAPATQKDSVMSSIATFSEAVQANKDAINRYHGGSLAAIPVGQKCYDCWYALREAHSKLTDAKFTPSESEEVVKQFTSLNQDSIDLLNLYRDKAPVLNQASVSFIVPIMMQALFREADDYSAALQALMPEKDIAPMKQITVDHKAAWDEAFAAYDPTRNTAPVQQWKSLMSVFSPALTYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEG9</accession>
    <name>A0A1Q5TEG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEG9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="17308" checksum="AD2865B20ACE55E1" modified="2017-04-12" version="1">MGEALVLTLDIFVNASVAIDWLAEHDRNTSLKALSRTTAKQMYSQIDKIPEYIDDETGLADGASVAHHLIMDHGSRARPDLPETPISDQIDVLLDFSEKGKKSEVMQDYFNVCDMLCRSAFGAKQIMPIPPKYSDGGGLSAPQGAPKGRHPVKKREPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEU2</accession>
    <name>A0A1Q5TEU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase TIC 32, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEU2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEU2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37489" checksum="9DC9144B43192B84" modified="2017-04-12" version="1">MEFKDIVATSGFAGYTLLHPLEGFRGFGPTLSEATFGLLGTSFKPERDVSGVEGKTIFVTGGNAGIGRETILQLAKHRPARIYLGARTESKAQQAIASIKEQISSTVDIRYIPLDLCSFKSIRAAAAKFQADSDRLDILILNAGTMGNPPVTTEDGFEIQLGTNHVGHFLLTKLLLPTLKKTIAHLQDSGATPDVRVVTVSSMAHVTSPNTLEGITSTPGLLAASTWTRYGASKAANILFASELARRHPEILSVSVHPGVINSDLYSYTKSTSVFIKQALGLTASCFFRSIATGAFNSLWAASTARENLVNGGYYLPVGYRSNGTAFVQDADVARGLWEWSEAQIAERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFB7</accession>
    <name>A0A1Q5TFB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgi apparatus membrane protein tvp18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFB7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFB7"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="148" mass="16144" checksum="8BDF64924B9D8836" modified="2017-04-12" version="1">MTLAEEFQSRNFSIYGQWTGVVCMILCFALGIANIFSPVIRIIFSVICLACSFIILFIEVPFLLRICPTSAKFDAFIRRFTTNWMRAAMYAIMCGVQWASLVTGASSLIAAAVMLSIAAIFYALAGLKSQEFVGSKTLGGQGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFD5</accession>
    <name>A0A1Q5TFD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFD5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFD5"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="345" mass="37315" checksum="90F9F5725E3C97A6" modified="2017-04-12" version="1">MTLSPQPGSAEKAIRKLDIAQVSLSLQDRLGLAKLKYQHGRIHGLMPTMPAMDSSDKPSDSSSDFSRSRCETPMTSPSLRAATYSRELPRSARNKHAVTFNSRVMQPMLSASRKRVRSDSDTERPAKAARVSWKSSHHLPASSPGLNRHMTTRRNPAPFMSEATIPELSSPAYHAPSDEENDPDLPLHSFNHVSSMVGSSPPRTPPPKHARLPRADRPSQHEDGADLLLYLANSPTPARVAAGSQHAFPPSTPPSQHAVLPTLTPNLGTPGQQFNFADFVNVTPSPAQPAWGGRTPGNPGRTPLATKDARKRLNFDALVPPSTSSPHLRGKETGLALQLGGELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFR6</accession>
    <name>A0A1Q5TFR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFR6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="135" mass="14685" checksum="E4B3E9B9E0075E6A" modified="2017-04-12" version="1">MPLHKNQSLKNDLWHFEMDEGGVGSGWTELDAGENVTNSRPSHGASCNVPDLQKGYYWGGITRTGGNTVTESSVTYLHFLTVFNMQQETMSTIPVPDFVPVVNQSLVILNTATRSGALVALGGYVERNGTLSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIA3</accession>
    <name>A0A1Q5TIA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIA3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIA3"/>
    <dbReference type="OrthoDB" id="5403280at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO99952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="56062" checksum="049B27FD1E207A5C" modified="2017-04-12" version="1">MVFARGDVSGHDDQAIDHNAPGSNIEIVSWNGPKDPENPYNWPLRQKWTLTYLAAFATFITMMNGTIITVAHAAINEEFGISDENFPHSYWPVTSWAVGGGCFSLLILPLMEEFGVRWVFLLAYVAFVCFVIPQALAQNFATLIVTRFFAGGCVSILANTSATVIGNVWDTEKARNIPVSLYIVTYLVGASIGPVIGAPIFEFLSWRWISYLQLIWLCALFPLYFFLFKECRGIAILGKRAKALRKEGRLAYTQHEIDSEGTSMMRIVARSATRPLLLFFTESVVFVSFMWSAFTVGTLYLFTQSVEQVFVGLYDWTPSQAGYIQAAIVVGEILGWVGTLFSGKIYFDSAARNTEVPGTPIPEARLYLAIVGGVLGISGGMFTYAWTSYANFPWIAPAVGLAMVGAGSVIVVTGISDYVVDAYAKYAASAVGIIVTGENTFSAFLPLAAMSMYNTLGFQWASTLLAFISLALSFAPILFVVYGKQIRERSPFMKEAMLEKRRKSFDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TII4</accession>
    <name>A0A1Q5TII4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phloretin hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TII4"/>
    <dbReference type="OrthoDB" id="3335931at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041526">
        <property type="entry name" value="DAPG_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18089">
        <property type="entry name" value="DAPG_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DAPG hydrolase PhiG" evidence="5">
        <location>
            <begin position="13"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="225" mass="25142" checksum="E00412A81E7BD74F" modified="2017-04-12" version="1">MNSPTPLPNGLPLTDAKHLISNPYLPLEAGISITPDGMHHIAASTYMPGSTGSMIDWWFGWIHKTPQYKLWHPRDHVFSDWEGPRDNNSTYIGGHHLVHEYIGGKLAKLKISFVDPGVYFGDTWKEDFKRAGYSTAVCGRVGNWDDESGEVVYGGHLVHLIKDEPDGVRMRSRFWLGDIPGLDAEQRRGAVDEGFALGLLRHATEEMAILASILPGMYEKFAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJE2</accession>
    <name>A0A1Q5TJE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-taxilin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJE2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJE2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="452" mass="52381" checksum="E6A15272996F93AB" modified="2017-04-12" version="1">MSSTTIAKKNKGKKVADPNETSKLLAAKISQLEQDAAGEKDQEQEIEREVKKATRDLNQLLNNIESPMTRLETVHKKYTELLADMKKLDRDYSKSKKRADQLQKDQEKGKSELNKTVTMKDKLEKLCRELTKENKKVKDENKKLDDTEKKARLIVNERLDSLLYDIQDVMAAKGNPRNEKVDIDLDEALRAKLKTISEQFDTRELHYKSLLRSKDAEIQSLTSKYEEQRRTADNETARGRALSAQVSTFSHTEAELRSQLNIYVEKFKQVRKPRLPSFSYSKTDISQVEDTLNNSNELFLTFRKEMEEMSKKTKRLEKENHTLNRKHEQTNRNILEMAEERTRNQEELERWRRKCQHLEALCRRMQAQGRGEGLAEGDDHLDHDDEGTESEYDDDYEDEDDLSEDGDLDGHDHGRDIPRTNGPTERPVFGPPPPPNLLEARATKNAVVNGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJF9</accession>
    <name>A0A1Q5TJF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7812</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJF9"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="220" mass="24489" checksum="58F209FA4EE39972" modified="2017-04-12" version="1">MAPPKITLYFDIISPFAYIAFHVLRNSPTFAKCEINYVPILLGGLINLCDNKAPISIKNKDKWINVERARWAKYFSVPICDSPPEGFPVRTLAVQRALCVVSQKTPTKLPSVIEALYHSFWVQSNSKIGEPAVFAQVIESVLGQEDTKEVLSAMTQPEMKALLTSNTDHAFKIGAFGIPWFECTNTAGQTEGFWGIDHLGQVVDFLGLDRSRDPGFRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJH2</accession>
    <name>A0A1Q5TJH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJH2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJH2"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="246" mass="27125" checksum="9DE3F97A136AA049" modified="2017-04-12" version="1">MATLLYPPDSGIALGGSTNRSSLQPLQPLQPSPLGTTGLPWLSPFTLSQSEKDFLLGKPYEQQVSKASNMPSISLQSEPPKQPVQRSRRSSTRSTKSNEDISPERAKHLERNRISANKCRMKKKKEHARMQTLLNTETAKRDSLMSEVGLLKDELWYLKNMIFEHAKCEHQSINNELAKMTQSILESKSGQTKCPSPTFSTSTWSDGSVLEEPGAPEHPVPLPAGGVGYGGCPEAMFDNFLNLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJV7</accession>
    <name>A0A1Q5TJV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJV7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJV7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="138" mass="15761" checksum="DED6DC826477F338" modified="2017-04-12" version="1">MFPPKDSAGKTQEKSCEGLRMGRLFDILLFSRRIEFETGTTNKVYWAVETPLDSSFSYGNINDEFYKLLARFGVVLGTRHIMQNDTPLSNSETTQREIIKAYREQGLDVISKVREIEASRGLVEDEKSMRAGPYVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJX0</accession>
    <name>A0A1Q5TJX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="5">
        <location>
            <begin position="126"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="333" mass="36406" checksum="6585F26300145DA0" modified="2017-04-12" version="1">MSVINISSTNQFSALLSSSRFVVADFYADWCGPCKAIAPVYEKLASQLSRPNHITFTKVNGDQQTELAQAYSVRAYPTFIVFEHGRSIKTVAGADPQKLSEVIRRLASEATNSDGGSGEGSGATWLGAEVAARYTDVTDQVDTKGLDLLNRDNQFGEPRVLFDTSKPSALAGKGKGKSEGSSSGADWVESDTDEQLMLYLPFQSKLKIHSLHVTSFPPAAGESDVDDDELPMRPRTIKLYTNTSHVLGFEQAEDTNPEQTIEIKPEQWDAKTGTATVDLRFVKFQNVTSLVIFFVDGEGESEKLRVDRIRLIGDAGEKRAMGKLEKIGDEPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM73</accession>
    <name>A0A1Q5TM73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_7321</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM73"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM73"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="497"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="830" mass="93257" checksum="0FC0E2701B565924" modified="2017-04-12" version="1">MASNLPAQPNLRVTIIAADGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEPFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLQMGGDEMLTRDLKKSNDNLVVHGKLIINLSTNLTATTQNQNGLQRQQAQSSTSSGLVPQVAASSSTPQPGSSLLDTPAAASSSSLNNRSSAIQPPPGAPNGSAPPGANAPSRANLSSFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTTWSRPSANYNEQTQRNQREANMQLERRAHQSRMLPEDRTGANSPNPSDSQQPSTPPPGAAVPSAAAPAAGAAGGAGSHANAVSMMATGATTAGTGELPPGWEQRHTPEGRAYFVDHNTRTTTWVDPRRQQYIRMYGQNQNQGGNNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPALRIMSGQCHVKVRRNNIFEDSYAEIMRQSASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVTLQDMEGVDEDLHRNLAWTLDNDIEGIVELTFSVDDEKFGERRTIDLIPGGRDIPVTNENKPQYIELVTEWKIMKRVEEQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRGYQEQDEVIQNFWKIVRSWDAEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPAALPKSHTCFNRLDLPPYKTHDALEHKMSIAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMK7</accession>
    <name>A0A1Q5TMK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal homeostasis factor ATX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMK7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMK7"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP01457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8374" checksum="5CC796C71D905961" modified="2017-04-12" version="1">MSDHQYKFNVSMSCGGCSGAVERILKRLDGVKAFDVSLETQTANITTEPTVSYDTVLAAIKKTGKTVNSGEADGQTMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMV0</accession>
    <name>A0A1Q5TMV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger BED domain-containing protein DAYSLEEPER</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_7255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000638">
        <property type="protein sequence ID" value="OKP01548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMV0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP01548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="592" mass="68776" checksum="D6180D36E32125FA" modified="2017-04-12" version="1">MIDQLHLSGEFTLVIIEFLRSQLPIRHKTEAATTTGSRQKKMRWDTKHSAEIWQHFDQVANYITGEAMVMCRRCGKTIPHPGRTANGTNSMNRHFMAGTCIQAANNTARQKTLHQSIEYMAENTSRSKPSFSEEQWKRCQVRGLAIGVNASSQRREAFLNLQSKEPKLLPIQDVKTRWNSTFLMLQRAKRLSKAYDEYCSEHNYPQFKLNTEEWRQVDYLLCITQPFHQWTTAISKIKDVTIHQIFRIYNKLFDHFDFSISQLKRKRVPWKATMRGALEAGRQKLSDYYSQTDAHGNLYAIGTILAPRYKLQFFSKREWSDNNYQWRKTYRGYIEKYLEPYQQRQKETEQSQFSRPSTQQKDDIELLLDDDNPSEPSQSQEKRTGPVFDDELTHYLNSGTLNKNPCDFWREHEHQYPTLASMARDVFTIPASGAGVERLFNSARDVCHYRRGRLSETAIQDLMMYRCISEFDLDTTDLTGESDKEEEPTAEERQQAALRREAKLGQFTPVPISDNEEDEDEDEDEDEDEDEAEGEDEIPWEVPYSHGSPTALLVPPMGLKLSPNSRPRREVPGPTVGVPWEMSMSTLGNAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQM3</accession>
    <name>A0A1Q5TQM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQM3"/>
    <dbReference type="OrthoDB" id="5405012at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="161" mass="18182" checksum="95A284050A1394A1" modified="2017-04-12" version="1">MAGQRVQQVIIREDVRRAAVISLSNNDTNRVLWETCEPVWDSADLLTSPSGSTDQMAVFGVKGVLVTEFVGPFSPQHHGYYRFIMRYIIDFSAQPRYRYRMYVSVAGPIGMPNENVGELHVFQESWPSANAQREYIEGDIRTLTNSVSLFGFPAAARLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U044</accession>
    <name>A0A1Q5U044_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger protein grt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U044"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U044"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP05854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="684" mass="77575" checksum="2C1C0646A27AFFA4" modified="2017-04-12" version="1">MADASKPPTAGWRIPKACQECRKRKIRCNGVNPCKTCQQRNTPCVYRDVIRHRRKKHEYPHSDNEDKQPQRVSPPVTQSFKTGGPSMMLEFPNSVSATHMASPSCQMQLYYGPTSHFSLMQHTYRDLVSNPTIHPAPSGEVEEASAGLDLFSFRRIFFGTPDTHEIGKSNIPSDIPMMFLPYELAKLFLSRFLTHLYHMLPHRPKAYYEQCLEKLYNPSPTIHPDALTQAIILISLATGSLGTDHFAWGDVLFDRVKASLVSYDDVSSSQYANYQNEQGRPNSAFLYLGSAARKALSAGLHKDVPHEDTQDQETIEERRITFWSLYSFETWFCFHVGRPSSLSLRDVAIEYAKDPFIRLLTEFCKTVSRSGDEIYGQRHESLLHMWRVARSIAHDLRAHEVQMQQALGFGLNGSIQTGSLGVRQTIFITLYYHTLLLTFRPFLIFRGHWQRDMQTSLQQPGGGSASRPTEMPTWLNEACNHTLTAARKTIHHLCEASRSNDFVKQLRYHGYFLASSTFTLIYDLLHDPTTATTHLPWIYASLQSLSTMREGDPIKATISAIQTTLRKINPSYEWSPYPKAEEYSSSNIQRPTSISQAPGNHNNQSWVPPDPSLPQRPFFSQQPDLSTPQWNLPLLDGPETGGSGASNEDLLDFTQSDMGWNFDFSTMDLEAFFSTHQAADSAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U089</accession>
    <name>A0A1Q5U089_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED17</name>
        <name evidence="3" type="ORF">PENSUB_6609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U089"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U089"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP05889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="104" mass="12003" checksum="C92766355EA75A22" modified="2017-04-12" version="1">MVESFTLPLRPPPEQSERPDTLPVEIAQINNQWGSFREVNEEVLRAKIAEEEARHGVQQDEEMGDGEQETGDADATERREQLYKRRLEITQFAMFVAFTPVKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0P1</accession>
    <name>A0A1Q5U0P1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0P1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10023" checksum="B1033B5F104181A4" modified="2017-04-12" version="1">MAHGVFTIPASGAGVEHPFNSARDAYHYRTVRLNETAVQDLMMYRCISKSEVDTTNLAAGSGEGEELPTKRDSKQRYEEKKDQVNLPGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U192</accession>
    <name>A0A1Q5U192_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_6239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U192"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U192"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP06249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="198" mass="22324" checksum="6362775903AA7ADC" modified="2017-04-12" version="1">MAVFLALIIPLPFTIKRKLFAFVSESPIIAKLQYGLKITFIFILILFIDSVNRVYRVQQELAAFAKDGSAVSAAHLGTDRMEVQARKFYSQRNMYLCGFTLFLSLILNRTYIMILEVLRLEDRVKLLEGDKKAGGKDSARIAEAGSVGEIGSLKKQLAEKERDIETLKKQCEGLTREYHKLGDEVSSGKSEKTVKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1C6</accession>
    <name>A0A1Q5U1C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1C6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="136" mass="14740" checksum="CD74F0893E27881A" modified="2017-04-12" version="1">MTVKENQRRNRRGSESVVQGAGDSTRGYGLESQRKRPLEHWSITPLRNGVGSDDLPIRRALCEVTNEQYAQKSRQEMQAQVNGGVGGMGSLADELEKVKVGLPRSKSVSISGRLVIHQESGAPTPKSARRENGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1H3</accession>
    <name>A0A1Q5U1H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Mn], mitochondrial</fullName>
            <ecNumber evidence="6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_6281</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1H3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1H3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="15">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="16">
        <location>
            <begin position="101"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP06291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="346" mass="38000" checksum="21EF6E65471189D5" modified="2017-04-12" version="1">MSAPTHTLPPLPYAYDALEPVISKQIMELHHMKHHQTYINNLNAALSAQVTATQSNDVPTLISLQQKIKFNGGGHINHSLFWKNLTPPGTPGNDLASAAPSLREAIVSRWGSHEAFVKAFGAELLGLQGSGWGWLVSKGGPKGRLDIVTTKDQDPVAATDVPIFGVDMWEHAYYLQYLNNKAGYVEGIWKIINWAEAEKRYTAGVENPLKLTKPSASLTETCRPMTPFAETPKSNCSANSNSISAYFSASRKKSEYEDKDETEEFDEIESGDDERDLSEAAELDTLLRGNRTAMVPPKAPKVAATKVSGIEQICGRTSVDRAFSNVRTVGPGWIKDPRAWFGDKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2K5</accession>
    <name>A0A1Q5U2K5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2K5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2K5"/>
    <dbReference type="OrthoDB" id="5407715at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF17">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="198"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP06716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="380" mass="40744" checksum="82E35220602490EE" modified="2017-04-12" version="1">MGSTTATQNRALWLSSFDKPLELINLPIPDATVGSVVVQVLNTVIQPYAEDIHTGKLPVFNLALPLVPHPSHIGRVYAVGSDAVLAKPGDLVFFSGSIHGRDDPDVGIIQGHHGGEGDSGRKLMQGEWRDGALQQYQKVPLETIFVLDEQRLVKELGYTPADLHELSFYVIGVGAVCEAAKIEAGETIAIGPATGTFGGISCDVALARGANVLALGRSEEKLQRLEKQLGNHERFRYVVMTGDDAADTAAIRNATPDGRGIEVYNDWASGGLTGSPFFSAAIRAMRPSGRIVLSGGPAGDVRVPYALVMHLNLKIIGKIMVTRTGVDLTLKMANSGVLKLGKRGGSTHNIYGLEQHHEAFRHAKKNSGFRVYTDIAPNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4M5</accession>
    <name>A0A1Q5U4M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5993</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4M5"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF67">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP07404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="561" mass="61660" checksum="E428909E39642CA2" modified="2017-04-12" version="1">MADRTSVDVEETPRLQIAKKSMWQSIFDNPKVLFIAFFASLGGFEYGYQQGVLGQSLVMTRFTENFPTVVASSTATGWLTSILQVGGIIGSLSAGVLGEIISRKYTMFIACCWVILGSYLYVGATVGNPACLYAGRFFTGLGVGLFSGVGPLYNAELAAPEMRGLLVSFYQLATILGIMISFWVGYGSNYIGGTGAGQSDLAWRLPSIIQGIPAACLACGIWFMPFSPRWLVKQGRDEEAQTTLAWLRKLPLEHELVQVEYLEIKAEAVFEERAFAKSAPKLAERERQSVFMNQIAQYANCVRSMDNFKRVATAWLIMFFQQWSGIDAIIYYASNVFQSLGLTGGTIALLATGVTGVVFLISTIPAMLIIDKVGRKPMLIVGSIVMFCSMVIVGVIVAKFQHDWPGHVAAGWTAVALIWLYIAGFGATWGPCSWTLVSEIFPLSIRAKGASIGASSNWVNNFAIAFFVPPMLQSWQWGTYIFFAVFLFVGILWVWFFLPETKNASLEEMDKVFGSKKGQEDAELLREAQRDVGLTAFVERLGSATGRDAEKKEGSDYIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4R2</accession>
    <name>A0A1Q5U4R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4R2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4R2"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="41658" checksum="A344E5E513E7277B" modified="2017-04-12" version="1">MPDDPENMRGTRDSARRHNPDHDETPAAITDANAPSKPASTSEHGAPSLASRIQNSAAGLARSAMQGAGSSSASDAARTLAGATQGKVAGPSALASAGSGNLASRDIAARGSGVGAGGTYSGPGTGESFRSEMTSSTVGGFEIPALSEEAFQRLGVYTDEMSVQLGSEQGNAYRDSSLSDLQSETGNWKGKQRAHDPKQLDYTSAWERADNPGSQVHTYEPQPSDGAAVISLLTDTSFDPDFGGTEDLDTDLAAAPPPLTAAEIKMLDSFRRQIGDSSDPNTQHQAPGLSSLSLVPDIDTFLQQNDPSAFTHSTDTSAAANMTLRDSVLEYLPGAEDWVTVHERYHDEVWGYLRPALEAAKAEIEERGPETQEGDENDGPAVRRLKMILKHMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5X4</accession>
    <name>A0A1Q5U5X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5X4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="78" mass="8922" checksum="5A84A27A85615365" modified="2017-04-12" version="1">MATRKSGNPRSIEKYVANKYRKGSKKTSDYYGEKHKTGVFNPKTIYSLENEGNGSKKGKECRELTSHIETYKSNDWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U716</accession>
    <name>A0A1Q5U716_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U716"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6318" checksum="CA68B453AB9E2B4F" modified="2017-04-12" version="1">MAVRLSEGSAAARKAERGATSMFCEHARRTRNVSASGKLLGTEIRARQIAEGKCVNTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U837</accession>
    <name>A0A1Q5U837_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_5519</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U837"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U837"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="424"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP08633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="554" mass="60924" checksum="D3274CDFF456B1C2" modified="2017-04-12" version="1">MPKPTSQLFNRAIDVASVLKIRRSFHGPTPDLATFCKQFRSYAINAKAGPNEVSSTLERRIHGIEEDTKLTETGRVLSVGDGIVRARGLTNIQAEELVEFPSGVKGMCMNLEAARVGIVLFGSDRLVKQEDTVKRTGEIVDIPVGLEMLGRVVNALGSPIDGKGPIKTTEKRRAQLKAPGILPRHSVNQPVQTGIKAIDAMVPIGRGQRELVIGDRQTGKTAITLDTILNQRRWNSSSVESDRLYCIYVAIGQKRSTVAQLVKTLEENDAMKYSIIVAATASEAAPLQYLAPFAGCAMGEWFRDSGRHAIIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDKHGGGSLTALPIVETQGGDVSAYIPTNVISITDGQIFLESELFYKGIRPAVNVGLSVSRVGSAAQLKSMKQVASSLKLFLAQYREVAAFSQLGSDLDAATKQTLRRGERLIELLKQKQYAPMAVNEMVPLIYAGINGLFDNIPVNRIMDWEAEFLAHCRHNKPELLSRIEDEGELSNDLEAQIMEVIVAFNKVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U850</accession>
    <name>A0A1Q5U850_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000565">
        <property type="protein sequence ID" value="OKP08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U850"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U850"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="45027" checksum="F8CF262EFB623429" modified="2017-04-12" version="1">MDALSPDKMERFHKLSDDFEPHLHDPLVSTKQLSISIALDYANADPTLATKASMLAVAHPMNRIMKSDGNCGWRAVAFGYFETLFALRDPTRLQHELIRIKSLSLLLGQVGQPEQLYGVFVDATADIFERTFAAIQNGERNEAFLVNAFNEEYNSNAVLTYFRLLTSAWMKLNPHSYHNFLSLPLEQYCATHIETAQTEIDEVGLQALVDVVIEGSGFGLEVLRLDRGEDDVLTPDQLSPSRPSGITISLLCRPGHHDLLYPADQTIHITPVVNYQYAMSSNYSQWDQNALSLDLDSHLMSIPNLTADSVFGAGSPMFSMASVSPAAASPFRVSSAQEMMYQSPTQSHPPIPPIPLSFSMPTRPSVALPLMIALPSRSSDGLQIRLNPLVMKPNLSHSLLLSTPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9V9</accession>
    <name>A0A1Q5U9V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_5344</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of Ku70 and Ku80.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9V9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9V9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKP09258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="672" mass="74477" checksum="E13832F55F2B6755" modified="2017-04-12" version="1">MADDSYARDEENFEEEEVDETSFRAVKDAVLFAIDVSSSMLEPRLSGDTKKPGQESPTSAALKCAYHLMQQRIISNPRDMIGVLLYGTESSKFYDEDGDRGSDVSYPHCHLFTDLDIPSAEEVKELRALAEDEEEAQKILIPSEERVSMANVLFCANQIFTSKAPNFLSRRLFIVTDDDNPHGDNKSLRSAATVRARDLYDLGVNIELFPISRPDHEFDTSKFYDDIIYKTSPSNGEAPAYLQPDTNTATAKGDGISLLNSLLSSINSRSVPRRSLFSNVPLEIGPNFKISVNGYLLLKRQEPARSCYVWLGGETPQIAKGITTLMADDTAQRVEKSEIRKAYKFGGEQVTFTPEELQALRHFGDPVIRVIGFKPLSALPIWANVKHPSFIYPSEEDYVGSTRVFSALQQKLLKDKKMALVWFIPRKNAAPVVAAMIAGEERIDENGVQKVPPGMWIIPLPFADDVRQNPESTLAVSPDPLTDAMREIIGQLQLPKGAYEPQKYPNPALQWHYRILQALALDEDHPGEPEDKTKPKYRQIDKVGSSEKDTSTSCTVILIDSQRAGDYVLAWSDQLDAAFDKMFGGTAATTSTLVKRGPKDSADSAGGPPAKRVKTEGGAGGIDEEVKRCYEKGTVSKLTVAVLKEFLTAQGRSSAGRKADLVDRVEQFFENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAG3</accession>
    <name>A0A1Q5UAG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAG3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAG3"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="621"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="777"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="912"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135615" checksum="8336DD6CFB364831" modified="2017-04-12" version="1">MPAGDPFSFLAAEEPKPIKEKKPHWRGKLFSKDKKDRSTSDQQIQDFLASNRPIPDNFAATKADPRDVPLTVSTRQIPPTHDVAQIPAPSIPSPLNDSYAAFNFKEHAPPDPRELPQQRELPPQRELPQPRELPQHPINPHKPRKGKGLRVVFSDRAPDVIGEGGDETDTPTIEISFSRKRSRDRQVAEQQLHRAPSRSPNPSRSHLPSLTVNTSLGDSEPRSRRAATPQEQRGGTSPNSTWKPPLMQHDTEFLSTLHIEKPGSRLSFRGSPDSHSVAERVRDQMQAEEGRALQQHRFDDDITSPTDDDTDISSPEVPPSQSPRSPNESVYDSLYETPPYSASAPSVKSIVQSIRNPPSPVAHRAQPNLSPIDPRIPPNLTPGSPAKASSGVFKLPTHEPQPAPPVNHAAPPPTRELPRSPQPPSMNQLASPSTGSSREPSRSPQPPKFSLRAVANQVGDTAFSEFKEYIGRYDSLFHMAAEKVKPIVETSLSEWIRASVWWFLRGKTRLESYARSRNTAPVTYAKQAVVDLGKAFWINENIVPDHYELSRYGAMGIDALLAVASTTGDKELVDLLSLHQNILNHLRSLSMSIKRNNILAAIFADDEHSPSQLDTSIWLRYPFFAPDVSAVLSGSASRSMLADAPGKTPDMANMMPLGDTSRFFSYGSMFVQACVSSRDDEGQQYAMPCALTIIRERSDWYVFAAITSQSQLVNVMVQSDRKQGPTWDDVEWQVRSNSMRVKLPRGFELDVMFKEDDFKTLWNIVRYTQKSEASLSPEAGETVVFENTLKVFQYMDTGSPKAFPADPMERCRIRLFERQVTVTEGTGTRNAHRGFRLTVLTSPKVKTLSNVKHIVGYGSPVVFGLLRGEDGSPALLLKVREDGRTRSMLMTFHEVEERTKIHSVLLSMVPRQNETKTREFQFRSYAIEEPGDAAGGRAPITHLQFPAGNAAVIDQEHAFVDHGYGPTILSEHLRAFIATEWGSVTDRINLGPGELKLGLDVNRITGMSLFRPAQQDLTVSLADNLIRPEMPDQISDFLQKATAKPMVRRFEFASMQDLHGFEEAVTGFKVIYDGIASSFTISRRRMVVPIYKKWEASLARIQIVRQEKIIQLIAFFSDFQHGTCMNFVLKGTDHIESFGRSGKFGIRIVDAKFALPKKDEDPGSDFVCLDMPEYPIEHDDITITFDKELDRTNFKVALPGSVREPSRMGSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAI0</accession>
    <name>A0A1Q5UAI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000511">
        <property type="protein sequence ID" value="OKP09485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAI0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="41604" checksum="8449D78F6B089EFA" modified="2017-04-12" version="1">MVVTQVEKLEPLPLRKEWMNDLAEAVAFLESLNLAHGDLRPENILLDRNRLKLSDFDCTAQIGTNYEACMAPYGRILNSNETDQGECGTFGFLSPRTEQFALGSLFYFINYGFEVYGNRCLTEDPYEHGPKVVDLLQNMEFPKLDGNPLIDNIIDKCWHNKYVTVSQLAAHTKTLLNERTDAAGSNGEGYREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGNREEGSNGVTTPIESSSLVWWRVVMGRVIHGLWYGLGNSWTSVLRSTNGEVTITERAKDDNSDDVDKNLGEEFLYKKGVCIDLERRGLLRLLCSGEPEQIGFTFDWYRHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAI9</accession>
    <name>A0A1Q5UAI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000512">
        <property type="protein sequence ID" value="OKP09481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAI9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="99" mass="11854" checksum="AB5E5AF638BFFD91" modified="2017-04-12" version="1">MTYEGHISKENRCRLFTGHNIMWQLEIQDHTYDEKTKLIENDAGGQAAPVERLTFRLSTQGQHQHQHQHQHQHQHQHQHQHQYITTSTHQRITVDLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB27</accession>
    <name>A0A1Q5UB27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="197"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="656" mass="72842" checksum="9563D0B463080762" modified="2017-04-12" version="1">MHSQRGVNDEHKSNTSPSSGEPASPTFSLEDLSLPRYKDEEDSERARRAQARAQARVSGEYGDLELGSVPLLPAGHPDEHRDLDDSDSDFFDYEEQSAHRNDPSLSCNLAGFYTWLRGPVPPHVYHIKPWFPRWQAAPARLVERWAPRKGVKIALLVGGIIFWIAVFFASLQASVAGQEISGYGKPVKLSCHHRLCCPAGCSAAILLEPYNIGNQSYNYRPLVIGGKPFRMDGRVSGLYRGDSSICASALHAGLISDSKGGCGILHRRGERDNFENYTKNGIESIPFRPSFPMSFVLTRQASSSGSSEAKLIECFDIRWSLFAFTVFVTAIFSMTVTSAPIFYSITFFIVWFQVAMASDPPGSGSFYGLLQVGLGRFLPGAFVGFALYYFCVRKTLGNLEAHADKTILWLGGCWVGALNSDTFDRIPISRLTPHDLQQQPGAITALIIIIGILIVSFLIQAHGFRREGRLVFTLRLYGIMLIGIIVLVLVPHMNLRIHHYILALLLIPGTTLQTRPSLLFQGVMLGLFINGIARWGFDSILQTPASLLEGGRLGTIPPPMNPPNIEDRHHLVFSFPNIPAHVDGISVIVNDVMRYQGFKSKDGDSVPDFAWSRQHNNQPEYFRLGYVHINALGGVWYEDFSVPSTWAIDGDFYYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC48</accession>
    <name>A0A1Q5UC48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-specific phospholipase C6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC48"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC48"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000052">
        <property type="entry name" value="Phosphatidylglycerol specific phospholipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF24">
        <property type="entry name" value="PHOSPHOESTERASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G17590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270868" evidence="2">
        <location>
            <begin position="19"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="456" mass="49960" checksum="B7781C43B8F63D3E" modified="2017-04-12" version="1">MNPSALLGLLAFAAAVTAAPPKRHATAHSSSSVTNFKSHIKNVVILEMENRSLDNLLGGQTLKGIENPINNGPYCNPYNLTDSTQGKVCSAAKDFDSILDDPDHSVTGNNIEFYGTFTPDNAAIASGKLTPSQQGFVHEQLRRYGDDVNKTSLAKQVLNYYTEDEVPVLTSLVQNYLTFNHWHSDHPGPTNPNRAYVLSGTSAGHGTNDDSFDSDVHGLTQRSIFQQLSETNHTWKNYYTNTGMVDAFFFDWTFTSGNTDKAVPLSKFYSDAKAGTLPEFSFIDPSCCGTGTNSMHPTGLISDGETFIKNVYDALRASPQWNQTLFILTFDETGGFHDHVPPPLAARPDNLTYTETAPNGEKYTFSFNRLGGRIPTLLISPWVGKGLVEQKGTNSDGQTVSYSASSILRTLGYLWDFEPFTPRVATSASFDHLITNVKRSDTPVALPKPQSFKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCF2</accession>
    <name>A0A1Q5UCF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000385">
        <property type="protein sequence ID" value="OKP10155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCF2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCF2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="133" mass="14894" checksum="F67C49E3D04AEC92" modified="2017-04-12" version="1" fragment="single">ISCEALLGNAENYHHFVAAIRPYSGQLEIARNIRHFVRSSSLLETSETKNRTRTGLFQDRYALRGASQWIGPGLEDLLLSIKQLSTELNSTQDNPVINTQSSEVYSGYTLDEEIRIATQEVLNKLAEEPLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCI7</accession>
    <name>A0A1Q5UCI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pheromone-regulated membrane protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_4370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF10">
        <property type="entry name" value="DUF1212 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_3G01440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1246"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1290"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1341"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="307"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="688"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="781"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="902"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="975"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1460" mass="161263" checksum="364BA9888E3B3DBD" modified="2017-04-12" version="1">MAEPERRRRRPAVYAMLRKMAATVCLGNAFIGRPSISAVAASSTTSPSTSVSLGSIREAELLRRQIKQLEEQLSKATHGSTTSTPKTPNVDSQTVTTSSRLAGTFHMNHETPTDGHAHITRFMMHKTRVFGQSHWMSGVAQFGDILLMIDPIASDETSKVILDMQKCKSLAKIIKERRRPPWPTPLTSDLPPKEMADTLVDIYLRTMETFYRVFHIPTFTRDYDAVWIPGASPDTAFLVQLKLILAIGATMYDDRFTLRLSAIRWIYEAQTWISEPEFKSRLNIQFLQTQILLLLARETVGVEGSFIWISAGELVRNAMYMGLHRDPEHLPKGTTFVAEFRRRIWNTVLEISLYSSIESGGNPLLSLEDFDTHLPQNLDDDQIMVENSIPSPEHSYTKMSIALALRQMFPVRLAIAKRLNGISDHSGYTETLRLDAELRASYKTSCKHLQGQSSEGTAGPSDFQKRLLDFTLRRYLVALHSPYFNASQHDSTYAYSRKVIVESSLKIWNYVFYSPSIATSAGCVEGETQENQDFWKMAICGNGNLRTCAAQACFLIAADLRAQLEEEEGLGPVTLRPDLLSVITDCKSWSLDALRAGETNAKGYMFLEMVSTLLGGLKNGLRKDQLSQMLVTSAEEALANCIEIFEEVLSEGSDEIGTSLDEVNDLAPYSLPELISDWGFLANLTHEAEREQPREDPRAEWGKSQRLAVPHRSSMPYLHESADIADTPLQDREGDKKEEVGKEKRSEETPPEQPPPEEAVPETLSFEYAKRRIRPTIEKLKQKASQLGERLGRPTADGDDLHPGVYHADWASGSQPPVSDITDNPHKTYEEKRQNQAQSSSEAHRLVRDLTQSHSGKRRKSRPKPYPHGDMSYIGGEDESAMESGLRYRSGGGGILSQLIKLNGGNQQGRGGMASRTPSQSSLSGPASRSDSESGRQTPGPGKKGKPPKWYKRPPNTSTSTLIGASGGLSGASTPVSSEVLSAASQRRGQQAERKMNLEDEIRVTVHIAEIICRQRYIIQLCRALMLFGAPTHRLEEYMQMTAKVLEVDSQFLYLPGCMIMSFDDPSTRTTEVKLVRVGQGIDLARLSDTHLIYKNVIHDVIGIEEAVQELDDIMKKKPRYPKWVVVLVYGLATATVGPFAFSARPIDIPIIFINGLLVGLMQHLAAPRSVLYSNVFEVTSTVVTSFLARAFGSIPRTVIDGKRQYLFCFSAIAQSSIALILPGFLVLCSSLELQSHQIIAGSIRMVYAIIFSLFLGYGITVGTTVYGLIDNHAVSDIQCPQTGAFKNPYVQRFPFVTIMTVWLLIINQGKWKQLPPMTIIALTGYISNYFSTMKLGSNSQVANTVGAFVVGIMGNLYSRLWHGHAATAILPAIFILVPSGLAATGSLISGVQSADQIKQNISSHGPASSTPGAGLASSSSVFSLGFGMIQVAIGITIGLFIAALCVYPFGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCT8</accession>
    <name>A0A1Q5UCT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_4274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000362">
        <property type="protein sequence ID" value="OKP10306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="92"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="251"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="56149" checksum="E836829A8C2C79E7" modified="2017-04-12" version="1">MGSVIHPTPSWQKRAAKKQQELANTIPPAWRISDAFKATFPVPFSDHRNDFINTEAIRKSGILTERELKITGEYDVEGLLSALADGSLTCAEVTLAYSKRAAVAQQLVSCLTETMFTEAQERAQYLDALRAQGKVAGPLHGLPISIKDNFHYKGTESTIGMLSFLDEKSTRNSPLVDILLKLGAVLYVKTNVPQTMMASHKAIFQTTDSHNNVFQRCLNPWNSALGPGGSSGGEGSLIALRGSPLGVGTDIGGSIRIPALCCGTYGFRPSASRVPNGGMRGCTTPGMKFLLPCAGPLSLGLDGIEIFFQSVMGARPAFSDSTVIDVPWRKVPQKPSLRIGVVAEDPIFPLHPPVRRTLVEATHLLEAEGHQIIHLSPEEGQVIQLNEVAWGIFSLDPAGMNHIKAGGEPVVPGMEYIYKQGEKLKGFHKPSWSDLSELDRLSKLAVFNARRAELREDYRKMWVRHDLDICIAPPAQSTAVPHDTFGLPPYTAFLNSLDMNVFEYCSLRIGHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDG1</accession>
    <name>A0A1Q5UDG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDG1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP10526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="330" mass="35423" checksum="6DEB34A37B3082C0" modified="2017-04-12" version="1">MSLPTTMKAVVVEQTGGPEVLQYKTDYPVPSPQEGQLLVHNNISGVNYIDTYFRTGLYAAPKPEILGREGAGIVTAVGPNTTGFEVGDRVAWLATGGYAEYTAVPADKTVKIPDGVSDEDVMASFLSGLTVLAFAKETYPVQKGDWVLLHAAAGGAGFLMTQILKSIGAKVIGTAGGAEKCALVKSLGADVVIDYRSEGGKDWVKLVKEATGGRGVDVVYDSVGKDTWEGSLEAVKRKGTIVWFGNASGPVPPIPLPKLSPKCVKIARPTLFGYIETREEFEHYTNELFSLLKSGQLKTKIHKIYPLEDIAQVHKDLEGRKTMGKPLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDJ1</accession>
    <name>A0A1Q5UDJ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_3835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDJ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDJ1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012772974" description="Acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63296" checksum="5DD70A70811ED737" modified="2017-04-12" version="1">MFTYLALITLWLHASIPVTAQEHTEKVWGVFAYTVHGDSTPNVLAEAHPRFLSDYGANQLAAAGAAFRERYLSSGGSINVSESAIQYLSATVLDSKDVDVFATTDQFVIASAQAFMQGLYPPLGQSGLVPSDTMGNGSSDLSPLDGYQYPQIVTLGKGDPQSVMLAGQGNCPMHQVAESEYRNGDYAQGITEITDAFYVRLWHEVLSGVYAESSASYSNAVDISDYIEYEAVHNSTIQTQLTEAEIRQARWWADHYIYATNGQSDSNSQSTIGAISPIAGQTLATSILRAFDMNIEEFGTGQKMTLLFGNDEPAVALASVLGLASEQRPNFYSRPVRGASLVFELYSFEADEVYPTYPGSDNLFVRFFMHNGTNATNFTPYPLFGYGPSHEYIAYSEFRSEIETFAVQTTQEWCLRCNSAAVFCNGVLDNSGSDSSKKKKGISPAVAGVIGAVVTLAVIGLLAGLGFFLWSKRKRQGNHKPSLGGFKGTGKLASDTDVTFRSPIWDASKSAHAEQSDDIAGGVVVRGHERLGSWEMGQQKKEIEDVDTSSQRHMSTLEDENEDEWRIHSGLQPVKIRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDP8</accession>
    <name>A0A1Q5UDP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3909</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDP8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDP8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP10606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="40502" checksum="808D1CB91C7F705E" modified="2017-04-12" version="1">MQQVSLYISGERDYTAIKGSTGPLVYPAAHVYIYTLLHNLTDGGRDILLGQIFFAGFYLATLIVVIACYRQVEVPPYLYPLLVLSKRLHSIYMLRMFNDGIAALAMWVAIYLCMKQKWTAGIAVWSLGVGVKMTLALLVPGIAIITLLSLGLVQSIVLGAMAVLIQVLLAIPFLQENPVGYLSKAFELSRQFMFKWTVNWRFVGEETFLSREFSLGLLVLHLSLLAIFSTVWVKPSGINVVRFLQDSIRGCQPPVALSRSFIMTVLLSSLAIGLLCARSLHYQFFAYLAWATPFLLWRAGLHPILIYTAWALQEWAWNVYPSTDASSTVVVLSLALQVFGVLINGLGEVGSKRGGAESRRKAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDS7</accession>
    <name>A0A1Q5UDS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055530">
        <property type="entry name" value="DUF7104"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23397">
        <property type="entry name" value="DUF7104"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="87"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1086" mass="118812" checksum="B7BEA3BF80E050A4" modified="2017-04-12" version="1">MESISFHGNNDRIQVGINHGSINNSVSPGYDWQRFLSRTNPVEDKKALKRKKGGPAPGTCEWVLRTEEITAWLGSEPTVGPESQPTQVLWLHGNPGTGKSIMAVYLAEELAATFSNTDGGTLAYFFCDSGFDTRNTAISVIKGLLYQLVEQHAKLLDYLLPKYHARGAELFASFDALWEIFITMMADENTGRKYCIIDALDECDRESQDTLLQQLEETFRSPNVSPNVRILVTSRPYPEIRESLQIFPNKDLASFPQRQKDVNIFIEEKVNFLAKRKKYTDKVKGQIREILQDKADGTFLWIGLACGELKDIPSSSVVRTLQRIPKGLTSLYTKLLEAALKDSESTGNDFRHLLSCVVVSSRPLTVLELAEACQLYQEEEDLETRLQFTHEYIESCRLMVIIQDEKVLLLHKSIKDFLVGTGSSNFIQELEAHARLAYRCVDLLIAQSRDANQSRSGFSVYATYGWANHARMAESSFTVQCSQAEFFEVDSPCREWWLRRVRAEYGFETLPTRFSIFHVAAEWGICALVDHAAELGAQKSDRECFRVDVNCVNHSGKTPLEHAAGSRWPNIVNALLKRGGMVTTEVVKAAAGNWFYGEAVMALLLDRCGDQITITDEVVKAAAGNEENGKTVMALLLDRCGDQITITDEVVKAAAGNGGNGEAVVALLLDRCGDQITITDEVVKAAAGNWFYGEAVMALLLDRCRDLITISDEVVSTIAGAFNDKIMTQLLDRRGDQITITDEVVKAAAGNEGNGGAVMALLLDCYRDQITITDEVVKAAAGNRFDGKTVMALLLDRCGDQIAITDEVVEAAARNVGNGEAVMALLLDRCGDQITITDEVVQAAAGNWFNGEAMMVLLLDRCGDQITITDEVVEAAARNVGDGEAVMALLLVRCGDQITITDEVVKAAAGNEGNGEAMMALLLDRCGDQITITDEVVEAAARNVGDGEAVMALLLDRCGDQITITDEVVEAAARNVVDGEAVMALLLDRCGDQITITDEVVQAAAGNEENGEAVMALLLDRCGDQITITDEVVQAAAGNEENGEAVMALLLDRCGDQITITHDVVSTIGGAFRERLTRQLLDRSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF25</accession>
    <name>A0A1Q5UF25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_3489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000306">
        <property type="protein sequence ID" value="OKP11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF25"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="49" mass="5475" checksum="D38793F49385D37F" modified="2017-04-12" version="1">MVGCSWVLFGKKPKSPVTSQPPTAEETAIIHDREPSCRVHEQIVQDTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFJ8</accession>
    <name>A0A1Q5UFJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin-like protein KIF22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFJ8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000072">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="749" mass="83014" checksum="175CBC40751E0A9D" modified="2017-04-12" version="1">MSVRVVARVRPLLKSERDLDVILRTGASAGAAETKSRESLNGDRKLAALRDRDNVVRIPNPKNEGEEYTFQFNAVYDADVTQQELFDAEVAPTIKHLFNGFDITLFAYGVTGTGKTHTMRGGKSLADRGVIPRLLSGIYRRSRKMEKDSNGETTVQVSLSYYEIYNDKVYDLFEPPEKRTLAGLPLRDNGGKTVVCGLTEKPCTSLKEFESLYDQANTNRSTSATKLNAHSSRSHAVLGVKITVTTPEKTRTSTASAIDLAGSEDNRRTENDKERMVESASINKSLFVLAQCVEAITKKQQRIPYRESKMTRILSLGQNNGLTVMILNLAPVRSYHLDTISSLSVANRTRKIEVREVENDPIFKGPARPAVRPSLAATRKPLQPLTASVHVNMPASVVKDPAKKDEEKPLKAFSVYSDRSQPKAVTQIRKSEISKLPSLSEAHPIRTLKPPRPSIVPPQMNYGDIYAAKIEEMVEKKVEEILAVRAVSEQSRQTEARELNEQLQRRLEQLEQRIEGTEDARAEGLSYLLMAKQHQARGESSSALRMYQLALPHFPHNEKLAAKIAALKERLHGKVQPRQSAAHVSPPKGRFGSMLSLKKEPTLTLGKRQAEDLDNEYMDQTGGDGFSSGEDSILPKSKKRATSKALRHNGGDLSVLDDYEDPSVSPRTIHLLSIINSRDVSQIKLLKGVGAKKAEAIVDCLCEMDQSLVTSDERISDQPQFQVSSLAELSTLKGVGVRTVENMRNGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFK2</accession>
    <name>A0A1Q5UFK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_3280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFK2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFK2"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="175"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="381" mass="43274" checksum="C2156FFC7AB0387D" modified="2017-04-12" version="1">MDASKIPDFLAEQQAQGTPETQTYFLTFEDFWERKLWHQLTDSLVEFFRMKESAPQRLPIFKAFVLSFADRINQLKFVALGLMASTECSDDNERLAFLTALSNKVNKPESQDAYVYALADVANVKLRVPDLDGAQKDLAACQKVLDSFDSVETVVHASFYKVNADYYHTKQEFASFYKNALLYLACIDLEELPETERVSRAYSLSVAALVSDSIYNFGELLLHPILDSLTETPHNWLRDLLFAFNRGDLTAYDVLAGNISKNKLLESHRMFLYQKISLSALTEMVFRRPPHDRSLAFGDIASETKVQPDEIEHLVMKALSLGLLKGSIDQVGQVAHIHWVQPKVLDMKQIDGMRNRLKDWDAGVNQLGHWIEGVGKDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFK5</accession>
    <name>A0A1Q5UFK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="55043" checksum="532F1AD06BE2A2B2" modified="2017-04-12" version="1">MSPECSSGTARSTDAPTPVNMDGQALLETYAKMMIPMFPFIPIPSHMSVEELRRERPFLYLNISMITSPNPARQQELSNTIKKYLADRIIMRGERSLDLLQGLLVHLTWFISVSRLHQTNFSGPIDGPAPNSNLPPKQPTQGTAQLDAFLHLAMAQTISLGLNQDPSSTKTMNQPIAYLSQVDLHRDRTPSRTMEDRRTYLGCYYTMMMLSVCAKDMESFRFTKYTDECCKILDESPELPSDRYLVQLVRTVHLAENINHTITVDEAVEYSMLITLGNAKAILSFHYDTLEMLLYHSSLSREISDTDYGNYPVTRLDILYRCLEATKSFFHHLYTLPAVYFRFLPFTISSQFGQAVVTLSRLTLYQSENGAWDTTYVKNTIEFDQTVDTLGQKLDEARALLEQDQSSSTEPPEIFKRLATRIKMMKDMHRRRQDAQEKTAQSQAVEHPCDMNYMFNMPADFFITDADFFDFAESFYAAGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFS7</accession>
    <name>A0A1Q5UFS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Self-sufficient cytochrome P450 monooxygenase CYP505E4</fullName>
            <ecNumber evidence="6">1.14.14.1</ecNumber>
            <ecNumber evidence="18">1.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Bifunctional cytochrome P450/NADPH--P450 reductase CYP505E4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">PENSUB_3156</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,4-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76763"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195422"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:76764"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,5-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195414"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:76760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>dodecan-1-ol + reduced [NADPH--hemoprotein reductase] + O2 = 1,6-dodecanediol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76779"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28878"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195445"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:76780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dodecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 5-hydroxydodecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76723"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:195418"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:76724"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 27">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 28">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="6"/>
    <dbReference type="EC" id="1.6.2.4" evidence="18"/>
    <dbReference type="EMBL" id="MNBE01000286">
        <property type="protein sequence ID" value="OKP11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFS7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="8 27 28" id="KW-0349">Heme</keyword>
    <keyword evidence="16 27 28" id="KW-0408">Iron</keyword>
    <keyword evidence="11 27 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 28" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="15 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="27">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00069187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="OKP11319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="457" mass="51625" checksum="B20800DA7EB2829D" modified="2017-04-12" version="1">MSSTIPQPPGIPILGNLFAVNPNETWNSLIKLAKEYGPIVKIKVLGKQIVFISSVELLEEICDQRRFRKCVTGPIVEMRHCANDCLFTAYDNEASWGIAHRIMSSHVTQAGTDACFDDMAKVIPDLTYKWTLTDKQPVLITDDLDRLLMASVMQCFFNQRVEALRDPEPVIIPALQRITMEAMKRPTRPRLLNWLWYQKGFENDIKTMRDFASEIIKKREGTPEESRNDLLDAILNGTDPETRKQLADTQAVDEVVTMFIGAATSSNLVSYALYYLMKNPDKLAKARAEIDSIIDSDQIQLDKLKELKYCEAIIRESLRLCATAPGFNIEPVPKQDKSPVILAGGKYEIPHDQVMIVVLHAVNRDPAVFENPEAFIPERMLGEKWDNLPSAAKKGFGNGKRECFGKMWALRWSIFVLASILKDVSFEFQDPGYKLVSNGAFSVKPLSFYGLVSPRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG26</accession>
    <name>A0A1Q5UG26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome c oxidase copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG26"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG26"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1130:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8275" checksum="70B2A1CC763A3C9B" modified="2017-04-12" version="1">MSWLFGSSSDKAAAPTEPKAQPAQSEKPKPCCVCKDEKTARDDCMLFSKSDDPAKECKSMIEQYKACMLGYGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI07</accession>
    <name>A0A1Q5UI07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI07"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI07"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="457" mass="52093" checksum="4FD13252D8557FAE" modified="2017-04-12" version="1">MGTSIQFSKYVGDESEGTSTVDSKQSSPNILPRSEGVAPLKDANKNDIPPTARWTKIDQLLVSPAALEAGNERYEERLGFVIVLRVLTKEEIQAYALKTEEIRGKLFQFESAAKGFNSTDNSLDLFPDACYEGYVRDKRRRREEKQRQAKDQDSAAREEKWNESRQAFVMGEEDKESLHSISIEDEASMGKRSTYGHKHPIDDPLVDVMPQEPLFYPPEYIGDDLEGTSMVNSMERSPDTLPKRAVDAIALLEHSRTNFGPEDPNTMAYMEHVVEVFWQHGRLRELKPLLNELLDLKPKQMGPGNASTLARMDTKGRMLFTSRNGYAEAEEVQTEILHIRKQIWCMEDPHTLNFMYWLVRTYTALETFDESEELALQLIEHTKRRAYKSLRKGDHKKGEELLLDIVEASEKHQHSLALREASELAAIDLDGAYFENGEPEKADAFKDLQVRGFSSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI83</accession>
    <name>A0A1Q5UI83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/calcium exchanger MaX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI83"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI83"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="361" mass="38013" checksum="338840F7A193783D" modified="2017-04-12" version="1">MNWDNICFNAATLIAGVFVLDYGADKFLDHTVIVGQRLGISPTLIALLTAGAEYEELAVVVAAIAQGHSPLALGNVVGSAISNVLGAFSLGILFHPGAMEFDRSAKIYAALLLFITTLFVVLAFFDQLNVVTGWLLIGGFVVYILSIGYAIYKGVTEAPQLSDSESDSDSDDDLPIARDDRAVGQDGMSENSPLLHDPSSVLEGHTVKPTMSLFYHLCQLLFGLLALSLSGYIIAHSAGALTQSLGLSGTVFGLTVIAFATTLPEKFISVLSGSRGQGGIVVATTAGSNIFLLTICMGVVAVTGIPVNHADNFVLFELATVWVSALCLVGIVFLGSSRIAGLALLAAYIVFIVLEFTVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UID6</accession>
    <name>A0A1Q5UID6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uric acid-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UID6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UID6"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="571" mass="60634" checksum="442930DF0CCC9A53" modified="2017-04-12" version="1">MDNSIHSTDGPDTIVPDSNPKLTVGRRVRRIAKKFTTKEGLIGDYDYGFLFRPDLPFMKRDPRPAPFFGLNEKIPVLLAFILGLQHALAMLAGVVTPPIILSSSLSLPADLQQYLVSTSLIVCGLLSMVQITRFHIYKTPYFIGSGVLSVMGVSFAIITVASGAFSQMYANGFCPVADDGTKLPCPEAYGALLGTSACCALIEVLLAFVPPKTMQKIFPPIVTGPTVMLIGINLISSGFEDWAGGSGCTTGLCPSATAPRAMPWGSAEFIGLGFLVFVSILICERIGSPIMRSCSVVIGLLVGCIVAAGCGYFDRSGIDAAPVASFIWVKTFPLTVYGPMVLPLLAVFIICACECIGDVTATCDVSRLEVEGEVFESRLQGAVLADGLNSIFAALATMTPMTTFAQNNGVIALTRCANRTAGYCCCLFLIIAGIFAKFAAAIVAIPNPVMGGMKTFLFASVVISGQAIVSKVPFNRRNRFILTASMALGYGATLVPTWFSHVFAATNNKDLEGFENAIELVLETGFAVTAFVAMLLNLIMPFEVEEIGAVRQVPSHATEIGDGPEGQIKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ88</accession>
    <name>A0A1Q5UJ88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000199">
        <property type="protein sequence ID" value="OKP12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ88"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="14029" checksum="C1456A28AEAF7AF1" modified="2017-04-12" version="1">MLGDAELGTLAAGITSLSAESTHYNDQLQDLLERFRNVLRDYSAIRDKFEEAKKTRQLEKQVRLDGLWENRFHNQLARGSSSFDMQDACKIYIPNSVATSHLDNLFSVNLLGELRQQKILYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJP5</accession>
    <name>A0A1Q5UJP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJP5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="77" mass="8604" checksum="6C96C0B480DDAD70" modified="2017-04-12" version="1">MVRKEPIRLKETKREYSKVTGFVKRPPDAPKGVLQSLLTRVSAFVGILSVIGQKTFFAQQDEATKELAKSSKRGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJT4</accession>
    <name>A0A1Q5UJT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJT4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJT4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="56785" checksum="C0D848D580E95A56" modified="2017-04-12" version="1">MDTISNFGVLSDSNYTPCSMNSSGKPLSRRACNECRRKKTRCDMRHPKCSLCSSVGTTCNYRGQHRQRVRKRSAAASSSSIDTAESGETRLSTSQSPFGLDGVVLMDDIDTILYNLRSIDDLVTPFSEPITGFGSFGAAPGPGAMPIIRECFPTPLEPSQIETEINSHYTFSITPNLAEELIDLYFEKVQGICPIFTREKFEQEYLPSGRSRGERFSKLSPVAQFVLNGMFALSARYSSSYNFEGLAPHCRDRQFAKKATELWESIQKDCSHSVRTLQCLQGLILLAFNCLQSGPSEIAWNLTGTCVRLAYDLDLHTMDADKIDSKPIDWPVRNQQRWELLEEKRRAWWTIWEMDTFSSTVSSRPYGIDSRVVRVLLPVSDQEWIKNSQARSVSLGSNTELPWQRIVGSSNQSERAWFLVCLAVLRRTVDTILSGASIQELQKVEDIIGCAFLALPFSFYDLPLSKATWQSNVVTYNWMACSLIALNWYESLSGNWDDDALLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKN9</accession>
    <name>A0A1Q5UKN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKN9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000074">
        <property type="entry name" value="DNA mismatch repair protein (Pms1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="221"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="800"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115160" checksum="7476E1090E630805" modified="2017-04-12" version="1">MATIQAIEARSVGILVHQIQSGQVIVDLCSVAKELVENSLDAGATTIEVRFKNNGLDLIEVQDNGSGISPENYENVALKHYTSKLSSFDDLSSLHTFGFRGEALSSLCALADFHITTAQANQVPRANRLDFEISGKLRKTQIVAGQKGTTASVEGIFKRLPVRRRELEKNIKREYGKVLNLLHAYACISAGVKFSVRNTVGKTKNVVVFSTNGNRTTKENIANVYGAKTLSALIPLDLELEFEPSAPMRCSGVGGGDGQSNQLVVRGHISRPVFGEGRQTPDRQMFFVNSRPCGLPQIAKAFNEVYKSFNVSQSPFIFADFQMDTNAYDVNVSPDKRTILLHDAAALIESLKTSLVQLFEAADQTVPQSQVLGSKASTTAKKQALGSLPGFVTARQVIQGTPGPAVTPARGQDVDDSEKESEASQRTVQNSIKRFMSNRGESDEVDTLSTPIKSTPNSQQTPMPSLVEPSSTEPDDENDDQSEQPLDNEMDEETPQPPPRPSSPPAEPDSALSQQSDESEEMPNVVQNAFDRMRPRRMPAEMATITIGDHMVTSMIGSGRPRKRASDVGYSSHGQTKKKRRIHTPSRPNIFGVQMKAFAAPGTQMDEDEGEEEEQGSGDDASETNEDGVIDEEAEEAPEEEGEEKAYSSEPEDTEYISEGTRESPDGEAENDHQPIEKASAAETDENALDEAEKKAQEEATVQRLIHQAEEKAVLPSEHNTSRANKMNKGAAHRDATVQLVTTIDASVSKLETQMAKLRESLQTQKVSSRKADTELSDEKTAEDRLSLTVSKADFAQMRIIGQFNLGFIIAVRPGEDHDELFIIDQHASDEKFNFERLQAETVVQNQRLVRPQRLDLTAVEEEIVLENRSALEKNGFIVTIDESGDEPIGRRCQLVSLPLSKEVVFGSRDLEELIVLLSEASSVSGVSVPRPSKVRKMFAMRACRSSIMIGKTLTTRQMQRVVRNMGTIDKPWNCPHGRPTMRHLMSLGQWEEWDEYGNEYTGEQEEGEGEGRGERPGGLDVWRRYVEEAKKEEEEEDADEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKX0</accession>
    <name>A0A1Q5UKX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Demethylsterigmatocystin 6-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKX0"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="166"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP13128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="393" mass="44010" checksum="BC6F81D62B0C8A13" modified="2017-04-12" version="1">MALSEALANVQTLAAQEAAGNKDSHADLLRAIRELQLAAETPLETTSRLNFQIMQNISIRVAVEYGYLHVIAAKDGQSISATEISKETKSDLLLTIRIMRVLTAIGLCDETGNQLYAANERTRFKILPGSVAAEKHHFDLDFGMGGKLVEYMRGPGIQQFADEPNAVTLFKYAHGTDVIFGLLEKNAEQKQAFDDYMAARRVDDMPQWFDIYPAAEKVRDARTEPGATLMVDVGGGPGQEIARFKEKYPELPGRFILQDLPLTLKRVEKLPDGVEAMKYDFFTPQPVKGSRVYFLRDVLHNWSDAKSAQILSRIVEAMDPEYSTLLIDDYVLPDTGSELRAAEMDILMWLHTAGLERTVSQWKSLFGQVGLELVKIWDSPRGNESVLETRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULQ4</accession>
    <name>A0A1Q5ULQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">PENSUB_896</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000129">
        <property type="protein sequence ID" value="OKP13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULQ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULQ4"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="54"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OKP13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="440" mass="49435" checksum="EA7BCC2C7C7359DC" modified="2017-04-12" version="1">MSLTNPPSSSGSISARAKTVSQNLKRSLQATVDESIESRRPGGYTSKVRVRDRYHIVGFISSGTYGRVYKAIGKNGQKGEFAIKKFKPDKEGETIQYTGLSQSAIREMALCTELSHANVVQLEEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPATMVRSILFQLLNGLLYLHTNWVLHRDLKPANILVTSSGAIRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLLGSRHYTPAVDMWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIVEILGLPRKETWPGLVAMPEYTQLQSLVLHRQPAHFHRGPNLEGWYQSCLKNGGYSSTSKTGTPGADGFDLLSRMLEYDPTKRITAQEALEHPYFADGGPISGDCFNGIEHKYPHRRVTQDDNDIRSGSLPGTKRSGLPDDSLLRATKRLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULZ7</accession>
    <name>A0A1Q5ULZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">At2g23090-like zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULZ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="7">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="48236" checksum="AF85D01BB05ACD2E" modified="2017-04-12" version="1">MATRLIHRKRWALPKQDSSIAPPHVWSNADQDPVPPEKWTWTGWTFTQYWLSDLVTVSTWSAASSAYQSGLSATDTVLLTLVAALCNAIPTVLNGAVGADLHIPFPVAIRASYGTYFGYFCVASRAVLAMFWFGIQSSYGGQCVTPSTLVPPMALAMVIWISVKAGGGSAMFHEPSTVHGTDRAWLWLMNMTSITGIFVSILPLITFNSNEALGGFSTLAVNISDFSRFSKKPGSPVWQLPMIPLFKVITGLFGIIAAGASKQVYGTILWSPLQIIDQWQGSSDMTTMCPKWFNIKRGMIMCMVLGGWALCPWIIIKSGKTFLSFMGAYSIFMAPIAGILCCDYWLIKRRKYDVPALYDPRGIYYYKGAKANQKRERNNADKSKAAKSQIKTNEKAMNIQCKVCLQTFLQTTKAPALLEHASNKHKKGLADCFPGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM98</accession>
    <name>A0A1Q5UM98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin synthase regulatory factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="737" mass="79490" checksum="B00C37FA08BA2E7B" modified="2017-04-12" version="1">MAAMDINGRGPPPRPHTSNSNGRRPDMRQPPPRGPLPSRGRGGYPPGPSRAASSGRTDRPDRAYGDPNGPSMGPPGRSATMPLATPPTMYPGQSSYREPDYASSPMGEMPPARPNTAGGMRPTRRPANELDPGLGAGLMVPPDPGSRISYAPREFLDSYYEGTDDEPDMPNFDAMPAEHKGPIDEMGLDTPKPMQTPTSPSSSAGGQYAPYTPDSSTSRSRSQPDLRQPTAPNQFEIAGFQFDIPNDAPPMPMHGGNGGYPPNSYDEPGYSLNGHAPYQNQGYPMEQPSPHDENPDALPHHPMPIPFRPGHDQKPAPVRQYGGGPGAAPGPGPAPGPGPGPGPGPAAPQPMPAVENGPKPVTHEELNQLQMKARGNPGDQKTQLLLAKKLVEASTVLVADNNRLDPKMKAKAKEKYVMDAYKIVKKLASTGYPDAQFYLADCYGEGQLGLEVDAKEAFALYQSAAKAGHAQSAYRVAVCCEIGAEEGGGTKRDPFKAVQWYKRAASMGDTPAMYKMGMINLKGLLGQARSPREGVSWLKRAAERADEENPHALHELALMYQNASGNDIIVRDEAYASQLFHQAADLGYKFSQFRLGTAYEYGLLGCPVDNRTSIIWYTRAAAQGEHQSELALSGWYLTGSEGILQQNDTEAYLWARKAATAGLAKAEYAMGYFTEVGIGVTANLEDAKRWYWRAAAQGFPKARERLEDLKKGGSRMQKTRLSRSAVNKQSDGDCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMJ7</accession>
    <name>A0A1Q5UMJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMJ7"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="565" mass="62643" checksum="5E9D40861A7904C8" modified="2017-04-12" version="1">MTSYKQSQLSQYRFDFVVAVTQASINATMKTYLAGFKEPEMKICYVVGHDPTTSQVVPTEIEFAKLLELTEGVDPFTVNIPATNPENDPNFQKLIKAKFMTGFKVQMGIPNAADLTKLPNIVGLRADTATVEYNLLCSEFTIAALQNEWGTYSWLQKSQDPNKPWLYSATVDLRMAEVPSSAYSKLPKDVKDKIKNLSGSAFSIQQLLFDLSNAGLSSAARVDGVQAGSALETILNRYFVSKYVAKLRDEGSPMLGLAVVPYETDKSSLTLTDLNFSTNPYIDPTGGDVVLPPGEREQNLACLNYLCAVNKNVLPPPTRFPWNWLEAGDLADHDGVVSVNRNNMRDWLEPSLKAVAKKHCLNPTAWAQHHDGNLLKLYVKIFFGPEEQEPVIERKEEGPTVLTLSFSGAASDDDQAGSIKLEYKYTLNVDFVGTNIVITQNVWVWYEAHAVSASNHDVVVDDLQTDTYPITVSNGELIVGESKKEPIQHRAHPQDRNSFVGAFTGLNRISDDIKDQLRGLTSIQLETIPVSAMQGFVFPGGNTFVFKNAEFSEHQDLLAFIKYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMN1</accession>
    <name>A0A1Q5UMN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_557</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000125">
        <property type="protein sequence ID" value="OKP13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMN1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMN1"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="158" mass="17448" checksum="0F9D72E9ECDA0EE8" modified="2017-04-12" version="1">MADEHEMTFESTDAGASTTYPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMDVPNVSRKEYQLLDITDDDFLSLMKDDGDTKDDVKLPDGDVGARILKMFREEEKDVNVIIQTAMGEEAAIEAKEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMW5</accession>
    <name>A0A1Q5UMW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013135476" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6419" checksum="97520347CCBD7D1C" modified="2017-04-12" version="1">MRFSSALLLVLPASFAVAVPVSSGTESAAEWFDRAYSEKRSPEEDTAAEWFDKAYESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNE4</accession>
    <name>A0A1Q5UNE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="98" mass="10939" checksum="E61F1B4E90469E5A" modified="2017-04-12" version="1">MGKREENDEGGDGEEEKRMAMKRLQASKDEPLKRLEDAGTNLQENIHNPEMRKSVGGELAKGSIGLDRQLLTDFEAVDISVLPTDNLPRRLYKKSDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP50</accession>
    <name>A0A1Q5UP50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP50"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="236" mass="26480" checksum="C6FD987FD6B6B64C" modified="2017-04-12" version="1">MPSKSSANKNSASGCGCRCFSLRNLSLLAVFLALFSALYSFLDARLNQFYIFDPEHLHDLSQRAIKAHGEDTRSIVDFIVAELQEKVGEKYLSTEEEWVFNNAGGAMGAMYVIHASITEYLIIFGTTIGTEGHTGRHTADDYFNILHGEQLAYVPGSFEPEKYPAGTVHHLVRGEVKQYKMDSSCFALEYARGWIPPMLFFGYADTFTSTLDFPTLWATTRITAREMVGNLLQFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ87</accession>
    <name>A0A1Q5UQ87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ87"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ87"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP14633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="494" mass="54584" checksum="1CB3290B1779EC23" modified="2017-04-12" version="1">MADYLLFESPMGYSLFKVTLQGDAVGNRLKEVQAGVNDLAKFGKMIDLASFLPFENNKQALGEINDVSEGVASETLISFLDLNLPKPSKKKKVVLGLCDKGLAGSIKSAFSFVDCETGDTSEVVQDLLRGIRQHFAKLLSQLREGDMDTAQLGLGHAYSRAKVKFSVQRDDNHIIQAIAILDQLDKAINTFSMRVREWYSWHFPELYKIVSDNQTYAQIALFVKDKKSLTDDSLHDLAALVEDDKGVAQSIIDAAKRSMGQDIGDSDMENVIAFAERVVSIAKYRKSLHQYLVSKMSVVAPNLAALIGEIVGARLISHAGSLTNLSKYPASTVQILGAEKALFRALKTKGNTPKYGLLYHSSFIGRAGPKNKGRISRFLANKCSIASRIDNFSEAPTTKFGEVLKQQVEERLEFYSTGAAPTKNEVAMKSAMDAVLAGIDVDVDDSDAEMEDVDAKKEKKKEKKDKKEKKEKSDKKKKRKHDTDAEPSKKKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQG7</accession>
    <name>A0A1Q5UQG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_11474</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQG7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQG7"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="243"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="555" mass="61966" checksum="E1C4297F52A1336F" modified="2017-04-12" version="1">MADSELPTRPKPEETKEAAPAEGGDSKNASKNALKKAAKEKAKAEKAAARAAQEKAQAAAAEANDTAKGLYGPIPETADVISTTRFSELSEEYYEKEVTVVARVDNARVQSAKLAFLMLRQQGQKVQAVIAAAEPISRQMIKFTGGLNVNSIVQVTGIVKKPEIPISSATISHLELHIRKVYMISEAAQMLPMQVKDAERPPPTEAEEGQVDAEGAPIVTLKTRLDNRVLDLQTETSQAITWISSGVAQLFSEYMIKSGSRWIFTPKLVGAATEGGSNVFEVKYFKRNAFLAQSPQLYKQMCIAGDMENVFEIAPVFRAEDSNTHRHLTEFAGLDFEKTFQNHYHEVLEFAEDLLVFILTQLKERYAPQIATIQKSYPKAGDFKLPKDGKALRLNYMDGVALLKEAGVDMSEQERFENDFTTAMEKQLGHIIRDKYDTDFYVLDKFPMAVRPFYTKADPKDSRFSNSYDFFMRGEEIMSGAQRINDIKELEESMRSKGLDPTQEGFEDYLNAFRQGCPPHAGGGLGMNRIVMFFLGLPNVRLASLFPRDPQRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQX7</accession>
    <name>A0A1Q5UQX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase subunit f, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000056">
        <property type="protein sequence ID" value="OKP14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UQX7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1432" mass="152498" checksum="0D2C4E7E86CC02C4" modified="2017-04-12" version="1">MSYIARRGLSTLIPPKIASPNAIGAAQDAARMERVVSFYAGLPRGPAPETKATGLLGRYQARYFNKNSPAHSSIVMAEQFGRDVVDQTLSGGELSPSGVPASINDNISAGGDVGETQHTTSNLTTQVSTDPQINDKTRHALGSQVEDTGDHKVAGGSAMVGAYGLGNGLITELNMVQDASKQGSGLVASRALELNGLTSVSDGGDDTASQGGSESDASRTDGRHHNRTGSVKKPTTFKPVSFAKFAVAKAPGAPAAPKAPEKVPSTSTTPLGTPQPTSRPRLVAKTTAGMRDSFSKTGAGGGKGAAGPDPNQVWNKNRPVQPPPPKHLTDEELKQQYGIHMTSRIQEDGGGTEAKWADIDDDEDDWAPETIEWTDGTKVTLTHTDHPAPPADLIPEESKDVAPVPEQTIARDPIKIAAPKPTTSVGPNATVLRLGANAERQAKAASISSKGTNDRAQSGSTSPAPPAKSPWAALPPVERVSPVNPPVHVSQPPRGPGPVSHPHRDDVRQGPYAPQEIAADDFNRTWRESAPGAPRELYNSRSGRYEPVQDNRRGSWRQDQGPRPPAVLQRPNHVESGGPAEPSAAFQTHRSTHQDGTGWNRRRTSSNVSGGSGGFGRRMSFGRDAPPPRYMEGRRGSQTNGMVDPALMGREPGPTHEGPPSQQHTAASWAGQAPRSVSVASSVEQATPASVPETPQEDPLVLQERIMKDARAQARQRRLEQEEKDRLEREERIKKKLAALGPPPEKPQSQRKQSVEASKPQTPAPPPPAILHSPPLHSPPKPPVPEPSGAPKQYGMMKVHHPDSVKKLVAANERDRATEKHTEKPTSPHLRRVQPSPREQKRELAKQPQSETPDEMGDDHGPGWRANLNVPTSNVPTSNAPTSNAPNSYAPWTNANMPSNPPSVNNPWKLLNSDRTLGNGIFDQSLGGFPSHEVPLRGQLKLDQPSVPPQAFSGPQESASISPLPSPETRHAPIGRPGPIGPPSSQQNMWQQDSGRHGGLPLPAWNNFDTLSRESTRAMQERARAQFEANKGKPNPIAASLQTEWKPLRGSSAETTQKKSVIGIAPGPVNNNKNGPPTNRLTGLDAPVDGLPESHARPIASVPARSSRFFPQASEQLKRPATEKSEHHRSPSPPPPEEVSTHPVYFGGSGRPLVHLPNPKPVVKLPPKAQAPPAAPAAPPTFASMAAAPPRGPPAPASGAISWQEKFNGLFGKKTPVERKSALAITSATKEPLDVSLSVPAVSVSLPSIENGVQIGDGHLAVRQVEEQDEIFEDREPGSLPSVRVPNMAPANAWTAAPAPPPSRQRAKVLKPMQVQSIEQYEVGSDEKDAAGNIRVVVRLPGAAEAMTLTLPKKAGGPPSRQQQQPLQQRNSSNFNKTRKGPKPRDASGSTSGAKKPSTPSQQQSSSTASSSPRHQSRTTSWGPRKQSGPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQZ1</accession>
    <name>A0A1Q5UQZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000052">
        <property type="protein sequence ID" value="OKP14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQZ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="15859" checksum="A3F70F56FB7EB85F" modified="2017-04-12" version="1">MTDPTCMFAPSQRYHSTANPPGASVNLGIWTVLEGSIIIIAACLPSTWPLIVRILPRGLMGKAFSQNHSRHRYPTKHAKPKGADGFSRLGKHATGTTDKWPLAANPSLENQSVSLSTHTLDPTLVNAESISLRSMNEIREEPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNS8</accession>
    <name>A0A1Q5SNS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baeyer-Villiger monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNS8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNS8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="520" mass="58225" checksum="452494442E831CC5" modified="2017-04-12" version="1">MTSKSAEAPTYSQIACVGAGLSAVALGATLQRWYGLEDIHFFERHPTSGGTWYINTYPGCGCDVPSALYSFSFAQNPNWTKLMPSNTEIKGYVDDVVKTYNLLPKMIFGTEVVRSVWREDVNRWLLYLRDIKTGREYAHECQILFAATGQLVEPRPCDIPGASEFQGNIFHSARWDHSVDLKGKNVVIGNGCTAAQIVPALIKKEEVKSLTQIVRTKHWIFPAPNFAYPKFLQWIFRYVPLAMRFHRLHIFLMAENDFRLFPMTKSAAKLREKRRKQVEKYMREASPKKYHDLLIPDFDVGCKRRIFDPGYLKSLHSERALLTDAKIERITSEGIETDKGFIAADVIVLATGFQTNKFIPYMDVVGRNGENVSQHWGKYGGPAAYNCSALSGFPNFFMLLGPNAATGHTSAMMAAENSINYALRVLKPVLDGDAASVEVTAKAEHDYVYWVQDALKKRVWNAGCVSSVLKPSTRSSSWVLLLALFCVAILGGTQISDARNISFGAFKMLCITAFSKLKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP08</accession>
    <name>A0A1Q5SP08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_13681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP08"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SP08"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="25"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO89615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="38895" checksum="E3547DEAA547ADB6" modified="2017-04-12" version="1">MSEHGLDWLQDKAIGWSHTPPVNKIDTHHHCVPPFYAKAVEEQGGDPSGWPTPHWSPLASKLLMKRVGVQTAVLSVTAPGACIIPNRQARAQLARRLNEYSADLRDKNPESFAFFVSLPNILDTEDALAEIAYGLDTLHADGVTLFTRYGSSNTYLGHPDVEPIWAELNKRGCVVFIHPTHPVDTNPVNSKLPQPAIDYPHETTRTAMDMITNGTRLKYPACKVILSHAGGALPYIISRVTTPMKRAPDFAVSHRMGTTHDKAMESFRSFHFDLALSSSPQVLDMLLKMVPHDHILYGSDFPYAPITAYPAFLEALESYEMDKELRDMINYGNALKLFPRLLRQRGGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQQ5</accession>
    <name>A0A1Q5SQQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carotenoid 9,10(9',10')-cleavage dioxygenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQQ5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF89">
        <property type="entry name" value="CAROTENOID 9,10(9',10')-CLEAVAGE DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="319" mass="36762" checksum="D0E04A9E3036FD4C" modified="2017-04-12" version="1">MTLDPTNMLRGRPIIHYDRNSPSRFGIFPRRNPEQVRWFETEPCFIFHTASTWDEPASKINEDCKVEVEAVSMVACRYTNGNMLYSMGAIKPIEKENCDSQIYYYRFLLSDTKKNMITQQMALSAIPFEMPIVPAIYANTGPKFIYGCSSRDAIFGAETGEPMKVDCLVKIDVQTLISRGIDEDTQSIDGCVDKRNIQEIISSEDPEDPIKIFQAPQGWYAQEPQFVPREDAKEEGDGYLLTLMFDKSQLDADGHASENTRSELWIIDARDMRTVVAKIFLPQRVPYGFHGHWFSREEIDKQRPYVRLRTEKKEEPKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRH4</accession>
    <name>A0A1Q5SRH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO90601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="383" mass="41553" checksum="1701685F30F28968" modified="2017-04-12" version="1">MATLKRKAPEFVDAPDATPTGRPVKKLRLTQSQKQALIDNLQLEITERARKLRAQYALQANDLRSRLERRVNRIPVSLRKANMGELFEKHSAPAQATSPIRRISPAKVSRAPMSIDQALSPSSTRDGRTRRNRYDRFDLYLIRTRPLTYPHSNEGHYSDKENAPAAGTPEGLKNPKRRGKAPAVGSASRVVSQEVRGHDHRILSPKSLNSRTYPQSPFRASPEKGQPSYLSRPTSPLKPSSPLRAAGPGSRPRGATVSTVRDNNLSTQAKKTTARSATGPRSVRSPLPRPATRQGERKNSFSSTTSSGTTVTKPARTGTGARKATAGASVTTKKPAVPRAHAASLAVKKTATSATASTLRKTTAPASTMDSSTRGTRALRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSG8</accession>
    <name>A0A1Q5SSG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAP1-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSG8"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO90903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="44511" checksum="F3EB522F9CB77C11" modified="2017-04-12" version="1">MTSPASPNTLSASNLQVLPPILTDNSVKPSQSARDRLSTYSNISFVSQQNRSRPGSHVFPIFHSSLPYALVRDFAYPSIHPLHYGPPPSHASGVSTPASEYRRLSDPPTSWDTSKGPWATTGGWNAESTQGHQQLPAMSFGDGPPYSEDEDLHSPVVTSSRQRKKSTGNDLNGMVDEHGMLVAGNATRGTFVGLNPDGSETYYVNGGDGVGDGPGGEYVTYPANEGQYSVAYGGQPGYAQEPGFESEDDYARGDRYSNDYQFAVGCPDEEMHGKAVALFDFVREHENELPLTEGQVIYVSYRHGEGWLVAEDPKTGENGLVPEQFVRLLRDIEGGLTSLNGEPNLDVTEVSLSTSMDMTEDEHVSTPTQDNHRGTNGDTPVSVSVSNTDQSQSTSETGKTVGSGNRSSMMTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUD7</accession>
    <name>A0A1Q5SUD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUD7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1158" mass="129426" checksum="F09247CBAD1692D2" modified="2017-04-12" version="1">MRPALLRLLKRPSAISVLDTLAATPTGIEQLDSRYARLRCQSRCAHQEALDDNPGSGSAVQGVETQKQTAGERRPFNFPIYEIEPLETDRYPTSSSPTKRTSEKDYSKCPIKSLRLQPERLQFESDVGHCDDIGTRLVDRAENMNNFELWEELLKFRQRHYGDKGTQDIWEGLTVRLPGIKLPVTGDQADFFWQSFVKLGLRRDLFLIDVMEYAMDLHRREGRSWPQLYESVVGGLLDRGLTKRALRWNKKFQACGLASPNDVLQVLLPVIRPTSLVERAHDWHHVKAVRPPLLLRTFRLLCRSAEGHQIYGPVMSTLIEQGYGEGAISIHPFLVARNDHPKSLSEIQPLLDYARMYGFWDENKKLQAYAKKRFDTSSETLDDVSEKLKQGVPDGTPFKDDIGARLLATRALNFDMVLGGLKMLGVSAIGPRSLRELAVRAHGSQDILDKIKTLRQAGISIGDSVFARLVQKLAAQNRDILLADLLLSDQHPDVLEDRATQESLLISYYIARDMQQYNMALAVLAELHPDDPDLLDIHFRKHIAAGDLGAASKIVDELTLRGRPLSEDSLDFMAEKVLTPRRPNHRPNPPPGQPLNTKREVMFIFRVLQRSVPLGGYVNPFFWKEMLKRLGMENHWAELRECCMWLVRQYKTRSKKFWAKTPAGTPTGQDDRMLKLIFSPPMQTALVAWGFMVPVTSATAAKAICLHPITKEPLIQWVRGLLLLRELEQAGLVLQKRVILDATRHRLATLFGRFNLSHSRLNRVLRRQNPYRWQRVVADILRAWGDPSFFGGLERIEPTKLMNPGRTPSSLRSMRLFNYLPLLLPVTLANPLNVRSTACNNSPDLCDKSYGEITHLGAHDSPFVRTSDSVLAGDQYYDTPTQLSAGVRMVTAQVHKDNNQWLVTIILVNSDSASASELGAEFKTANITNYTYEPDSLTTAPTSWPTLQTMINSGKRLVVFATPLTTSTDYPYLMSEFDFVWESNYDVTSPSNFTCEPDRPSSLSGSISTALSSNRLPMMNHFLYSTDLAILDIEYPNASYVSTTNAPSGGTGNLGSTATKCKTAYGGRQPTFILVDFFNKGPALDTVDSLNNVTNAVGRTSVSSSSTSSSSDGSTVNNVFKGLVELASSAKSGASTSMGDWVWAGGNWNSILGGGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW60</accession>
    <name>A0A1Q5SW60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW60"/>
    <dbReference type="OrthoDB" id="3922785at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="24006" checksum="AF257B9A536662AD" modified="2017-04-12" version="1">MQALTRYCHHGFPRIPDPKVPSPELSQETSDLEVTEFFGPQTLTAEKRERLLSTTLEANPTVGVAGATFQGTKFARSSVTSYASRWQFEGSRFATDYSVGNNSRNRRYRRVVWHLQENELEKQALQQNIVHSAVAFTHQSKPFYLDVKIEARLQRWHDRLKQKLVSPPRNRKTCARAAIQTSTRNSIDANFAKLARDLTLFLVGSSCPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SY17</accession>
    <name>A0A1Q5SY17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000738">
        <property type="protein sequence ID" value="OKO92884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SY17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SY17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="304"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="775" mass="86592" checksum="EA5173900021C4AE" modified="2017-04-12" version="1">MTFSQSSSVTPAPLDSAWPPAHIWETMGAADRASWLGQIQRDRARRLELDVAETDLRRRRPRVDLQEDDILEENREPPPEVKPLIDIFPGVSAALLTRVFERKLKATELIRFKEKSVTELDQEDRVFKMTESGGTVGFKKAAASLKDWGPNPQTWTTCFLAYLAVVGYLFGEKHPKAVPNLLMFMRQILDFAQTYQCVTDSVAFNPLSLGLTPQGQPARPNTTVQYPVFNPELPRLQSSPSPLYTKGWSNLLRHYPGDLGSTIAGILTYGVQVGYTGKKQSRYSSNHHIYEPGMITAKLAEDLNLGRVRLASGPSFVSPLGLVPKHDGGWRRIHDLSWPPGQGLNQGIPDSWSAIEYMTIDDVYKQVIQAGLGCIIIKRDIKDAFRIVPVAEDNQHLLAFQWNDSTYVECCLPFGLATAPFLFNLFAEALHWILQCLLPAFYINHYLDDFIAIARSPPASDPTGPFDKVYNEVTDYLRIPRNTKKDQQGTCVTVLGIQIDSIAMEARLPPEKLCRATLDAAAALNAASLSLKQTERLTGLLAFCSRVVRLGRTRLQSLYTFQAAFPHGSSARRRIPYEVRDDLEWWRNSLSLFNGVLLIDPCRRSITHLYTDASNTGQGLFFFSSKSTLDCWLAHCHQLHPSNAATLALAQDAHAHINTNEVDAILQGFLLFSHHWLHHTLVIHTDSSTAHTGLKKGFLHGPPNAPLKSLLILAAARDIHIVPHWLPSGENKLADALSRNNLEDIANICPHWQDLSVLNRPRGSLHELLSSIQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SY38</accession>
    <name>A0A1Q5SY38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000737">
        <property type="protein sequence ID" value="OKO92893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SY38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SY38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO92893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="691" mass="78342" checksum="D6FD0C650FD17CED" modified="2017-04-12" version="1">MPVKRGAPRRSCDLCHQQKRKCDRSSRIDQGGAGCSRCITQKRECHSEAFEQTDVPKRQRVMARSPSRESSVWENGINPVGSTSQDSLLDLPPSSSRSTSIVEPHELSRLRSDPTHFSSPSTMEVTAASSEPGLHQVLQSPPRLSFSGAAFLRSIFVVDEQAASFRSPSVTSTFPDSQISHSPDSSTLPSLQSAPVSPKLPQPDIASNDFRLAHSHVLQFLVDRLVHSREKFDQDIFVKCHLTVKDLAESLRAYFDIPGIFHPFIPEDAFWEDLRAGICSPTLLAAIASRGIPFTNAKDKWEKQKLLVVMCMDEIMEVGVSRDGSERLRLDDLEAMALMMDLKYKSPHLFLGYKHEWRRLFAYDSLVKETLKGPNREPMASDPSGLLARADERYMLLYFHVYTLDSFQCLSRKTTSVIPDDELSMIEDTSCRGGGGYLDAMLGLAIIARRILRTLCNPAAPEAGIDYRDVICLYELLHEWRKRTFPSERRTPKDRADELTLEERSYWKSTPVSTSRQIDLYHTILWALEIDCYMQIDDCVSRYGWQDNGSIRTEAVTHRIEYESLQAMFEAVDLAELIRRPWPADQDAGRRPLVDLAPSILRNICADVCDWVCLRGKRHWELLDSQTVENANLSQANSGQLSEQETQRLRVLHYAGIAKLLRDTVAAASAHRDTKKMVQDLDYHLIRLQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ30</accession>
    <name>A0A1Q5SZ30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypoxia up-regulated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ30"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ30"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000084">
        <property type="entry name" value="Heat shock protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012976713" evidence="6">
        <location>
            <begin position="36"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="605"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="805"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="940"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="812"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="852"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="957"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="984" mass="107439" checksum="2FE119772ACDCA4F" modified="2017-04-12" version="1">MALPGRGRLLTSPFLSLVILPFLIFLVSFTSPAAAAGSAVLGLDVGTEYFKATLVKPGIPLEIVLSKDSKRKESAAIAFKPTRDSDASFPERFYGGNALALAARFPDDVYINLKTLLGVPFNDGNDEAVKGYWSRYPALNLETAPDGRGSVALRSNRLGEAEKKDAFLVEEILAMQLKEVKSNADALAGKGSDVRDVVITYPAFYTAEEKRSLALAAELAGLKIQALVSDGLAVGLNYATSRKFPSVSDGEKPEYHIVFDMGAGSTTASVLRFQSRKVKDVGKFNKTVQEIHVLGSGWDKTLGGDSLNDLIVNDMVAKLAEDKKLKDSVTPEQIKAHGKTMARLWKDAEKIRQVLSANTETSTSFEGLYDEELNFKYKLTRANFEKMAAEHVARIGGPLEQALAAAGLKLDEIDSVVLHGGAIRTPFVQKQLEKICGSSKKLRTNVNADEAAVFGAAFKGAALSPSFRVKDIRASDAATYPIVLKWNSDGKERSQKLFTSVSQVGPEKQVTVKNLDDFEFSFYQQVEEEGLPVLSVQTVNLTASVNKLKDTFGCTTANITAKFNIRLSPVNGLPEVTSGNVSCEVESEKKGSVVEDVKGFFGLGSKKGEQEPLAEDEPSESITLEPEAESSTTASVSSSTTTTTKENAKPTTQTKLEIIPISLKSTPLGTQAPSVAEMARIKGRLTAFDASDRDRVLREEALNELESFIYKSRDLVDNEEFIQAVKEDQLTLLQERIAKASDWLYEDSDNAKTADFQTKLKDLKTIVNPALKRMKESSTRPARIQLLQDMLKNAESMKQLIESQIATDEETYSSSLSASSTSTAEESETSSEATPAPSASDDNLDDLDDDSYSTSSSSKTSTKSAAAAKPTGPKYTLFNPTDLASLTTIYESTKPWLETQLELQEKLTESDDPALTVVEIDFRLREFERVLNRMYERMTAAAGREAKKNSGKQNKKKTSEEKGKGKEKAKEEKKKAKEETKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZF7</accession>
    <name>A0A1Q5SZF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZF7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZF7"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="431"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="820" mass="91215" checksum="F9C0B4A5EDC07691" modified="2017-04-12" version="1">MMMMAAHILPAQVSSRSSSVSQEQSLDLVAPLSLSSLIRTRSARRRTVCLSATVEEQFPKQHPSFSRRGSILRKLAGPRENAKRFLRLRSAGVNSPAPPPQQRLNPRCSGARPVSEIIVSSSRTREPPRSLEEGDMRSDSSSMATDVLARALPEHITAVPELSTPFPPLRNEKIVATGSGLTVGIALTEPVLFLQGYDHHDPSTKKSAILRGQIHLKVTKCVKIKKISICFRGHAQTDWPDGIPPKKIHFHDKKDLFTHGVVYFNHGDTALMQNDYGAHYYQHAKPTSPVPGKEGVTATTRELFSKSGSNTSLGLMTAKDAKRLSVQSTRGHSRSFSRNEPPVSTPNQPQRNYRMFPVGDYLYSFEFPIDGSLPETIKTDLGFVRYDLEAIVERSGAFRPNLLGTLEIPVIRTPAEGSLEQVEPIAISRNWEDQLHYDIVISGKSFPLGSQIPIAFKLTPLAKVECHRIKVYVTENIQHWTADKSVHRLQPAKKVLLFEKRAESASTSTYPGSSMRITAGGGIDWDHRAAAARGEEIVDRARTNLLGNLNTDSGVGPTEMEFNVQLPSCHEMRGRDEAQRLHFDTTYENIQINHWIKIVLRLSKVDERDPSKRRHFEISIDSPFHILSCKATQANIYLPAYSRPTTEPDPPAQEFECGCPGAPPASREYTLGQSSPDREDSASTLHRPNSITPVSRSFTNGSGGLARPPQAHIAHEPSVEREVPRPMHLVRAPSFAPPAFEDVPPPPPLMTPPPEYMSIVGNNDREAVLEDYFSRLSFYEEQDDERGLGRVDVPLTPGGRINRSMDVPREWVRIEDFTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T077</accession>
    <name>A0A1Q5T077_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T077"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="11490" checksum="F52DDB921C4C85FB" modified="2017-04-12" version="1">MTRFDRYPNAYASFYPLGRPVRSAHYSTVLRRSKPALIYSPVPDSADKQVWDSKANSETPLNLQPPPRGTKKASNGGGYYAGAAESRDIPQGTRTCVNEILSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0M9</accession>
    <name>A0A1Q5T0M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0M9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0M9"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="216"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="418" mass="47272" checksum="D32B4FA7C58DE503" modified="2017-04-12" version="1">MAQDQPAEPSAPKIKPSENRNADPDLAPRPAVPARRGSALLNFLSSLLGSKNPLAHAADSHKNTVWLFDNTAYQPVSDTPHLGHAGQSWQAEFVVCIFETEGRKDVGKLVAAIADHIGIDGEYGRDDQETRQRIEKRVQPFLDQVSPARTVKLEVTINGAKQTHSLGGSDRNGIISQIVNLGASGVSDGMVVSPRAQKFDEPTATMETRFAAPEGWMVISDIDDTIKRTMTREPTGILRTTFAEEPVPIAGMPEFYRHVQDEFNPTWFYLSASPYNLYPFLHQFLHEHYCHGTLVLRDYSWMDISGLIKSFTENTQEYKVDRMEKIHSWFPKRRVLCIGDSTQKDPEAYAEMYNRYPGWIHAIAIRKVTDVEHMEEKNKPERFEEAFQNVPDSVWTIFEDSQELYAFVDGLGMEDQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1G7</accession>
    <name>A0A1Q5T1G7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin-L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000722">
        <property type="protein sequence ID" value="OKO94050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1G7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1G7"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000086">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000126">
        <property type="entry name" value="Cyclin domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="300" mass="32842" checksum="802C07F1C5025E2E" modified="2017-04-12" version="1">MAQTNTGLKHLSNALATPDQLSNSSSSIDGVPTDLETSIRCAGAQLTQAAGVLLHLSQDIIAQAIVIFTRFWLGVDGGSLRIYSAKDVSAASLYLTAKLSFQPTSPRSILNVYNLLLSQDVSPLSFVNPRGAPKQPPAADTYVLSEGGYQAGRLVLLRVESVILRTLGFDTHVALPHTIALTYLQTLGVSRPAVSRRVLEHLNAALLSPQLLYVTHQPNALAVAAIYLATREEGVKLVDGEWWEVFDVDREELGFLVVGMRSTEGFMRKETELWKNKAIPMVIDEVDAEVERRRMMDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2Z5</accession>
    <name>A0A1Q5T2Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2Z5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2Z5"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO94587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="529" mass="59713" checksum="E2A1A9D1744D2CFE" modified="2017-04-12" version="1">MTRNHKFVTGMDSSSKMDSPSKQLLLDLVNDLENANIFNTDLKKVRAYERRSFYETLDRIDRELEAQHTAALDEAAALHDRVREQAEVILQEHIRAEEEERKRQEEAARKEKERIERIQREKAEQLRRQQEEAARAEADRKAKEEAAKKAAEEAECARQAAQKKKERQEREERERAEAEKRKQAEDVKKAQQEAEAKAKALELGKVGVSGLTADEARIQARYVEIHKTLKQLRSWLQGLVKNDPSAKKAMGDMRRSIKKCVGQLRDGKGVNKTQTQEIRAELEKACQMPGPSIDIRPFIAFPPDEIAQTEHKVPAMLIYGLNMLSKALISALIGEASIKSAHAEPIGIVAAQIFSMDSFMFKGLPMSDILLAKYRVVCPALWGSTGDDKTESGRQALGWWRLEAGGPFVSEQTHMDRMTALGAGFSALTLRNFGKAQRPNPFPNTIFWTSIQKILTIAPADMQETQIALLYGMLRGSSERILVFFGQVGLALLRRAIVELPAALPRQTMTVNQLKLLKDTYAQDRCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T364</accession>
    <name>A0A1Q5T364_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000716">
        <property type="protein sequence ID" value="OKO94690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T364"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T364"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="94"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="232" mass="24837" checksum="CC53925A418AAF99" modified="2017-04-12" version="1">MSKPKFLFVLTSQGILPTRQTPTGWYLPELVDPYNRISLLFDIVIASPNGGEAPLDPFSIESTREDPECVAFLKKNSSVWKHTLKLESLLGNSSGFAGIFYVGGHGPMFDLANDEVSHALIREFYEAGKVVSAVCHGPAALVNVKMADGSYLIAGQEVTGLSDTEEDIMQFTNDMPFLLETELRKNGGVYVKADSPFGVKVVTSGKGGKLVTGQNPPSAAVIGDALIKATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T428</accession>
    <name>A0A1Q5T428_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000710">
        <property type="protein sequence ID" value="OKO94925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36385" checksum="3892AF4F1D8FF2D0" modified="2017-04-12" version="1">MAPRNASKDPGDNIKTGQQQLANLASRPHDFSTLQPTLCDIARNFLCARWHRQRQASQVGQQWYEAAARNLERADHISEAASVAFDMEASQRRRSTLTSPSESEIPRRVTRQNEERIPPVRDSVAAEPLDRTVRYVTASMLRTDSVPWSISPAEPATVSGFNIGAGMQNLELHSLTRSEEVSHIHCPFCLADEEDQADESVILRCKQCRGLAHLGCVEEWLEKXEVASNVSCCACRNDEALDALLRSPRTIPTNPDTAVENARLRASPVTEETDAIENPRRAGSARLPAQSVSSRRRSAVSGAGRSVRRSARLANTTPSLRRSSRLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4F5</accession>
    <name>A0A1Q5T4F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4F5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4F5"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="332" mass="37788" checksum="5AC10668D904FA15" modified="2017-04-12" version="1">MLREVKAKNPRTARILKAREPQLIEPPKKTLLLHGTKCPQSLDTVLKTFHSLTKPNSVLFHKKNENLHPFENTESMEFLANKNECGLVVFGSSNKKRPNCVTLARIFNSQTLDICELILLPPADKNAIPPINELNMPVGLGMRPMMLFSGSPWEDPTSSSHVMLKSFFLDMFKGEETNQIDVEGLQYILMVGAEEPRDNLSPVIHLRWYKVITKRSGHKLPRVELEEVGPKFDFKIGRQRPATPEAMKEAMKQGKRPNEEMRNKKNITLDSMGDKIGRVHLGKQDLGGLQTRKMKGLKRRAGIDSDDEDEDLEMMDVDEILEDEGHKRARTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4Q4</accession>
    <name>A0A1Q5T4Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_11282</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4Q4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4Q4"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="21">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKO95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="259" mass="27513" checksum="74EBA1061ECF22ED" modified="2017-04-12" version="1">MFRPVARALARAPAVAARSPASTRLISTAGPTSKSRSWKSTFARLGLAGGAIYYYNTSSAFAQEPSFSLLGQSKKEKTDDSSLPTLDSITPKIREEQAAARSQPKADAPAPEVAAPDAGAVEVNPQIGIDSEEPPESAAFNPETGEINWDCPCLGGMAHGPCGEEFRAAFSCFVYSNEEPKGIECIEKFKGMQDCFRQHPDVYGAELEDDEPEADASAPVPAAEGEAAMPADVQAQLAEGDSLTTKAHFEAEQQDKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N2</accession>
    <name>A0A1Q5T5N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor GTPase-activating protein glo3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="429" mass="45607" checksum="7E4299E486BFF172" modified="2017-04-12" version="1">MVLFANTDKRTCADGLYVEWQWEQLRVMKVGGNESATKYFQSHGGSAALASKDPKTKYTSTAAVKYKEELKRRAAADAQQYPHEVVITDIPAGTPSDGSGTPAGDQDDDFFSSWDKPSIKRPSNPPSRTGTPPVVSRTSSPFLNAGAGANGSRSKSPLSATEEKVSSPAPTAIRANTAARKTTTTGAAKKGSILGAKKVPKLGAKKVVASDIDFDEMERKAKEEAERIEKLGYDPEAEQAEAKAASTPAITSPTPISPSRAGFGATGKTHERNSSDVERLGMGMSKLGFGQVSKPAAPKKLGFGAVAPAKSKADEEELAQAKTRFGTQKGISSDEFFGRDRFDPNAQAEAKQRLTEFDGATSISSNAYFGRPEDDLPAIDDGYGDLENAAKDFVRRFGITAGDDIENLSHLVGEGATKLQGAIRNYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Y4</accession>
    <name>A0A1Q5T5Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Y4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="7678" checksum="98F251DAA732C7FB" modified="2017-04-12" version="1">MSTQEASDSTVSFGQIYAILNLDWMPLLINAVAETTEGKLGSTTIFNKMMPFIARAVALLPSSRPSLSTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T603</accession>
    <name>A0A1Q5T603_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T603"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T603"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="46"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="32484" checksum="1049FE92ADA2CAE8" modified="2017-04-12" version="1">MASFRALRSQYASLLKQFAASTKEFEVLATVPTDHAPPPKILYVLDSSFNPPTRAHLRIASSALLEKLEPGSRLLLLLATQNADKPSKPAPFEDRLAMMELFAHDVRSHLAARDPSVSASSMEHIPTIDIAVTKKPYFIDKAAAIEASDHYPSPLEQVHLTGYDTLIRIFNPKYYPPEHTLQPLSALFSQHRLRVTLRPGDDWGNREEQESFVDSLARGDRDSEGAQREWAQKIQLIEGRKPDDPPVSSTRAREAAQSAPQDLEWLIPDHVRQFVISETPYSTESPGTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T645</accession>
    <name>A0A1Q5T645_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T645"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T645"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="172"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO95682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="453" mass="50695" checksum="FAE0987BFF8BFBE0" modified="2017-04-12" version="1">MGTDQVNALQAIGVPVQTINSSTPLAERRLIMTDMLSGHPRTRLLYVTPELCQTDSFRRNLSIVHRQGQLTRIAIDEAHCISEWGHDFRPAYQELSWFRKNLDDPPVAITALTATATPRVRSDIITILGLNFAKLKLFNTPSARPNIHYEVRYLPNYDEDDDISPEDVRVQDLLAWLKAIKSRQEARIGAHAAAQRPPMSGIIYVGLRATSEDLASRLDSDETISAVAYHAGLNPQDRTRIQAMWTSAQPYQQGSNGKPPPTFSIIVATNAFGMGIDNSQVRFVVHWTPPRSFEGFVQESGRAGRDGKAAASLVYYNTQERDRIADRLGRDAENVRNRGGPKAFVAGLLKNQMARRESYQKVVRYCETVTKCRHALIKDLFGDYELEEMGSQQPQSAYGVVKPDPLNPSASPCDYACDFCKEGPSGLAKRRGRMDAADALYGFMMEQMNYEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6L4</accession>
    <name>A0A1Q5T6L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_10883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6L4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6L4"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="13">
        <location>
            <begin position="86"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO95862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121170" checksum="39811C4973B43135" modified="2017-04-12" version="1">MPGVIMEYHNGEGSVRRPGLNEATNGAHGSMGSEKFGQRPTLSNGPVHVNGTGREADSSNQLSKATQRMEELTITPYEIPHITQGFFSFGTLVNRAVQNCWNELSELISELATIQVPPDHSTAHGAIGKSPGNQSAQNMHKKLKILEWGHAKRAEFIKLLVLSDWSRQASEVSRLIDIQGFIRTRHQAYSNAMNFLGVMKQDLVRAQVANPDLKTALEVLAKGRVASLPDFGYKPPKPLSARATLKKLHKINRIISARLILQDQVPHALRQYRVHDGRVTFTVAGEFELDLSVAQEAKTSQFFFVDIRFLFTPSSPIPKGRILNELEVEVNRILYNDGLLACFNFLHGLVLTNKINTLFRQAQELARGLWSDLLRIELLHRTLVVQYWPSRAGPKSWIEIGVRRSSPDSSIKVPHLNLRWMRDSQQAHSVDIKFDTDVLSMERILRSVIALHTSHVLSSAYATLRKHLLFANHVLSLKGQLSSSEPSDCYLELQLTTTRHLRVFIEPQSGAITLSGTPSVVERLEGDRAPAKPAVEELLTRIARLRCATAVEEIESGTKALGLESVNHRAVGLDIRKLFPPNTVRSAFFTHQTWDRRWIAAATSSMDGDQWWLVQLRPEARRSALPYGVTDGTSSPALAHAVSSTLMGTGRRFDYTACAELVYGLTGILAIYANARCLTDLPGVRFQPTLEKLELGSDLQVPDLYIDYKRSSLPAAFQIPLPASQLQKDSFVGSTICLSFQGVDRKSNSAILVASGTLQRRIKSLNMLISQVDPDIIVQDKGGGFALRLVVPAGQSAVVGLFERLQRLDCVIYILQKLIQKGMELQAMSLSQFIFLYGPEKKLRATFGIDVSGPSPSAPINIPQIISQGTPIFSLRLKLSFDSPSPHRRIQESLGVMLNHRFAEVGIDPILALMADTFPLLRSLDQMITKPAQSESALVHVIVRSPTVFQIHYPKLRYRFRLSAHLRQGRIEWLLEDTNRPPPVEPSQVSAVVRENVYNAKGDGWQGLGDGARASTHRVGDLLSKLHECLGTCQPVPEPEPVLQSTNGNTKPAQSKPASKSAEEKPAPPPQAKPKTTSPKKKKVAGNNDVITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6T2</accession>
    <name>A0A1Q5T6T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6T2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6T2"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002333">
        <property type="entry name" value="Deoxycytidylate deaminase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="196"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="347" mass="39438" checksum="6BE3F0985012C1CD" modified="2017-04-12" version="1">MLIGLCGAICAGKHAIAEYLIQHEGFQLLELATKPTQRITDEPDDDLRLQASEIRKNRDRKDRDGQSELVLDTPEDLLDFVTKRWQEKWVTTDIADGSTLDRFLLRPFFLLVSVDAPVSLRWKRFSDRCWRRQLDPPDLEKFVLWNDRHLYEKDIGRVYLTDRAQVRLFNSSSSLEDLHRALKTLDLADEQRLRPNWDQYFMQLASLAAQRSNCMKRRVGCVLVRERRVISTGYNGTPRHLPNCNEGGCPRCNRGDGGGVGLSTCLCLHAEENALLEAGRERIREGAILYCDTCPCLTCTVKITQVGISEVVYSQGYNMDSESAAILEAAGVNLRQFSPPSNGLIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T828</accession>
    <name>A0A1Q5T828_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T828"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T828"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO96371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="266" mass="29862" checksum="6114C39C013C9859" modified="2017-04-12" version="1">MADAQFDSALDLLRRLNPRDTKANLQAITTIVPDLTEDLLSSVDQPLEIRRCPQTSRDYLLCDYNRDGDSYRSPWSNEFDPPLEDGTVPSERVRKLEVAANEAFDVYRELYYEGGVGSVYFWDLDDGFAGVILLKKGVTAGSQSSGEWDSIHVFEATDRARMSHYKLTSTVILHLANETDALGEMDLSGNMTRQVEADLPVESDASHIANVGRLVEDMELKMRNLLQEVYFGKAKDVVGELRSLGSLSETNRDRATQLEMIKGMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8Q7</accession>
    <name>A0A1Q5T8Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maintenance of ploidy protein mob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8Q7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8Q7"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31863" checksum="121B9FDD9F39B7FC" modified="2017-04-12" version="1">MSVPAAPAPVHLSTTPIKSLSPSPPARGPSLSLSPSVIYQTTRTSHIPSLEPPSYLSPAVRALKQGVFGLTPPSNARTRAPFKPRSAAKGTSSYQLRQFAEATLGSGSLRKAVKLPEGEDLNEWLAVNVVDFYNQINLLYGSITEFCSPQSCPEMKATDEFEYLWQDSENFKRPTKMSAPEYIEHLMTWVQGNVDNEQMFPSRIGVPFPKTFPSLLRQIFKRLYRVYAHIYCHHYPVVVHLGLEPHLNTSFKHYVLFIDEHKLASGKDYWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9L5</accession>
    <name>A0A1Q5T9L5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9L5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO96927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="259" mass="28325" checksum="2AA09813D4A5D875" modified="2017-04-12" version="1">MAPSARQTDFDAQFLDHLVGTTVTTYYEIEPPQELSAVSLASEAPVPLSAGPPPGVSPPPVSFTTASPPPVSHTTASHTTVHPTAAPSATELSLSFPGSPPPKVCLSWIITEKLSESALYLAQDQVNMGAGPPMTVGKFLCHLEEDPAQIAFMRIYYQIPVTGTEYANLATRAQQGCPGRVCGEHEAFKVLMREGCSLVPRFLGYDERMQRQTDLVPNGFIKYVVWEKVPGESLTEELFWSLDRPTRDDIRAKFRAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAM8</accession>
    <name>A0A1Q5TAM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Haloacid dehalogenase, type II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAM8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAM8"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29929" checksum="331EFA7E0872B6E5" modified="2017-04-12" version="1">MSQDGFPSILFFDVLGTIVEWRFCIAKELNTAAQRALQDEARSLSPDIRARVSDMSTSCWQEISEEWHGAYMNFGNTYDASKSFISVDEHNHNSLENILTKRSLRELFSEDDLDNLTLAWHRLDSYPDSVPGLSLLDTKFPISTLSNGNVKLLEDLKGYNSLPFKHLTSAEHFGAYKPSPEVYHGAAKRFGFSSSQCCLVAAHLEDLQAAKRCGFQTIYLERPLEEAWDSKGVARAREEGIVDFWVRLGGEGLIEVARHFGIESAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAN5</accession>
    <name>A0A1Q5TAN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">PENSUB_10093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAN5"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="199" mass="21637" checksum="6BB36577381969A2" modified="2017-04-12" version="1">MLSYFGWGSSSKSDSDAPTQAQKTPELDQNASAPPSSPQTPAQPPQIAQQSASPDRTNLKLFAGGMAFFALSVYITRRANIRKRLACIPPYYSSSIYFQPNVNGAMEAFEALNLATINVISFSMMATGGIMCALNVNGLEDMRRLMRGSLEGVAAGKSDEQLEKDVAEWVSSVLGDRFDKQLEKEKAKKRVAGQSEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBD3</accession>
    <name>A0A1Q5TBD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_10348</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBD3"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 18 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKO97554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="397" mass="44795" checksum="07FE8A3480F46418" modified="2017-04-12" version="1">MSNDKGLEDLAEGQIESNYDEVTDSFDAMDLKPELLRGVYAYGFERPSAIQQRAIMPIIKGNDVIAQAQSGTGKTATFSISALQKIDPNLKACQALILAPTRELAQQIQKVVVAIGDFMTLECHACIGGTNVREDMTALREGPQVVVGTPGRVQDMIQRRVLRTDHMKLFILDEADEMLSRGFTEQIYDIFQLLPQSTQVTLLSATMPQDVLEVTTKFMRDPVRILVKKQELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMEQGQRDVIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMLREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBM3</accession>
    <name>A0A1Q5TBM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_10344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBM3"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO97550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="236" mass="24155" checksum="E127CD5A6D4142EB" modified="2017-04-12" version="1">MADTAPAQTAMPATGAPAAPTNGVTTGASNAPSDQNTTNRGLPYYEKLRRELRDTIQKKRLMDKSMAQLEDQIYRFEQTYLEETTAGNIIKGFDNYIKGSSSGSSLGASGLSLGSGVGGRRKAQVTDSDRVFSRSSASYMQDSPGPSTAQNTPSQAATPTSTAGGNAPSTKSNGGESGTASKAGGGGGGGGGSSKNKKKASGGSKNTKGKAQTEELSDDADSKPPVKRLKISYGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBQ1</accession>
    <name>A0A1Q5TBQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBQ1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBQ1"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="437" mass="46673" checksum="4AB17407905BD0FA" modified="2017-04-12" version="1">MAIQGLRELSLHSLRTFKHNYVSEISGSLGDLGTFLPIAIALSANGTVSLASTLIFSGIFNILTGLFFGIPLPVQPMKAIAAVAISRSFPSGSIAAAGIFVGVCVLVFSVTGLLHWFANVIPIPVIKGIQVGAGLSLVISACNSILRPLSWIGPSWADNRIWATVVFLAFIVTNVYRKAPYILVLFSIGLVFAIIRTAVAGDLPAFSIWHPWLVVPTPSQWWVGTVDAGIGQIPLTTLNSVVAVVHLANDLLPNIQTPSITHIGLSVAGMNLVGCWFGAMPVCHGSGGLAAQYRFGARSGASVVFLGVLKLIIGCLFGETLVDLLKSFPAAFLGVMVIAAGLELVGVGESLNTPRARDLPQTGCILDDADQHLGPICTDEESRRRWTVMMVTVGMLVGFKNDAIGFAAGMVCHWVYEIPNLREKYLSHWSQGYLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCD2</accession>
    <name>A0A1Q5TCD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium channel tetramerisation-type BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCD2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCD2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49262" checksum="E09B98783B947CCF" modified="2017-04-12" version="1">MAGDSNASTPASAGKSPACTLPSDKVFAIQIGSELFRLSGASIASDAPSYFSRFFEEQLRLTDASNVRTLYIDRDPATFQDIARHLQGTSRPDTSYHVRPRDGAQFVKLFADAQFYTLPRLMSQLFESEIFIQIGDRHFQIPRDIFSGPGDSPNFFSLGFGAFFASPSEVFPGLDRVGLLRPPAIVPPSVPNRSADVFAELLHLLRGYPLHIRNADHRAELLRDCRYFHLRGLEQKLIPHHISYNPFRQRSEIIIRLEDVRPSGVHFAPDTTSRTGVGSVLYARPFVDENPADLILEIADASTLVNRTARRADFVGLTKSRMASLLQVVAKKMNLSDSQLGAIPIRVRWGQASDIMIDGVSNPSCPANFAPDLETDDDLPPAKRHRTDTPQISYSEPCVVRTGQWRLQVEPDNNGAYEAVLVAVKLDTWLDARARNQQQQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD98</accession>
    <name>A0A1Q5TD98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD98"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="309" mass="33603" checksum="8B90DDD8A1DCAD53" modified="2017-04-12" version="1">MAALPSTYDGPVSIAVIGGTGLRELPGFTQVASLNVSTPWGEPSSPITILHHQCKHNNKTVAVAFLSRHGPHHQIAPHEVPARANIAALRSIGVRSIIAFSAVGSLQEAIKPRDFVVPDQIIDRTKGVRPWTYFEGGVVAHVPFGDPFDEGIAKVVRECGHSLEGEGVVLHDKGTIICMEGPQFSTRAESNMYRSWGGSVINMSVLPEAKLAREAEIAYQMICMSTDYDCWHDSADVTVEMVMGNMKSNAANARHFVTAVLDALAADEHADLITAKHLAGSIKFGVTTPQTNWSPEAQKKLHWLFPEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE71</accession>
    <name>A0A1Q5TE71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="55"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1503"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1748" mass="194501" checksum="13C08FA4B6BC2A85" modified="2017-04-12" version="1">MALNMDFSALKARTLGSGADEEAVTVDTRGLISKVLARYSGKWSVSEKIYAMENLTVLREMIQNAADASATKVTIKFETLPSLTVPSPSSTDPTDLLKHTISNHTLRRLLISNNGLPFSEKDWARLKRIADGNPDETKIGAFGVGFYSVFDDCEEPFVSSGSQAMAFYWKGNALFTRRLDLGETPSRDTTFVLDYRNDSSPVPSLMQLCQFLSSSLTFVALEEIELWIDDWNLIKLSKKTAPGVNVPIPRDVETKTTEGLMKVTSITQEVAQVDAAWMRIVEWNPNASMFRLDNLRDTTSSLRSFFSKFTGQTGPEKPANTQQVEKVDETANMTVMLKATVFLHINTASIQPSISTALSKELERATRKPPPKRATIAILTPSYDANIATGASESQSEILASILPTKAGRIFIGFPTQQTTGLNAHVSAPSVIPTVERESIDLNTRYISKWNLEMLRAVGIVCRIAWSAEMSTIKSKLAAKVGSTRASKIRKEDIVDVLPEAIHTANQFVFRESTPSSVLGQTIEDAFWMCNKNASIEVLSTCGVIPSHQTRIAPKDLSFMDSIPALPEELVLNAKDFVQRLTDFGLVTEITVSDIKRELESNTLRPNQIMEFLSWLSRKAVSGQLDSMSVKSLLRVAVANDEDKDSNPTRLIVFADIAGFLNPHRIPADLPVPPSVMPFRFTKSLSKSELEALGWGELSLVPWIRWLVTNAGDENLLGKEQNILTSPAFAGQVLPVLSKGWEILGSVSRQAVIEILQPQTVIPTRLGMKQPTQTYFASVRLFDDLPVVHGLNGVKEKFLVSLGVRKTVELGVIFDRLINTPEAVDAKGPPARRWNHVDLIRYLTSVREDIPANDIQRLKNTSICTAENDAQSRGTRYKIAELYEPKDSLRALGLPIIEWPGIYNNASNEGKFLTMMGLKSYPSGSELIRLMVMSDSEKDASRKSKALAYFLNEYHANGYAAFDISAVTVPFLPVEGSDNLSTPKRCFTDEGASLFGFNILQKRLHPHASKLGVKPHPPMSDCLQTLIRQPPTTQRDARTIFKYLAGRVSDLSPQDVERVGNAPIIPVPVNPMSEKGPRTRLVAPRLCYLGDGEDYKNIFDFVDFGPEANLFLMAAGSRREPTKNEIARMLVKEPARISAAFQSSDKYLMLLRTLAEHLSVLKKDRELFSDMKKAKFLLASRDIPPQATAQDGKVKASEKDNADPEEDLDIREWSLSAAKDIVVVDDFQSFNLFKEHIFAAPQEEALENFYVALGAIPLSSLVEEQARFGGVAADQSSGAKLHKVILERARLFLHDQPADSIQHGARWLETSFVVQVVNSITLTRSLKGRRASHTQKRSAIVARLSSNWGLCICPGKYDLYEISQSLVHLILKRPKLHSTLTLEMLLKTDLLELRARGYNVERILRQKAHEARMAEDQRQKQMEEERRILKEREAAWAEAQAQRAQEERPEPKPQAPMPGVFPESPNGKTSVDETHAAPTQSAIPERTPRGLFANLSKRFGLEKNQSSSTAEQSRSLLPETSTPPPPPYSASDSQNKRPEQPVSVSSPHRLNQELLSAVQACRPHGSSDMYSRPETNQISESKSYCDEKPSHDLEFVATLPSGVNVLFVRTITDRSAFLANNRTGINLFASVLLDCGSIFSMRADSLSIFYDPGGKTIAFNRAGSIFCNYFYFQQLQEQSLLQSANPDRTDAIVYWWVILCHELAHNLVGDHSSAHSYYTEGFVAQYFPRVAAKLATLPQHQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEF5</accession>
    <name>A0A1Q5TEF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEF5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEF5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01697">
        <property type="entry name" value="PARVALBUMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="124" mass="14091" checksum="295ECFA8BF64043A" modified="2017-04-12" version="1">MIAIFDEDGGGDVDFQEFVTGLSAFSSKGNKEEKLRFAFRVYDIDRDGYISNGELFIVLKMMVGNNLKDIQLQQIVDKTIMEADRDGDGKISFEEFTHMVESTDVNLSMTLSTYTLSLVLRCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFD3</accession>
    <name>A0A1Q5TFD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase FCK4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFD3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFD3"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53457" checksum="E250637FD84FD60E" modified="2017-04-12" version="1">MQANVIIAATYANTKAESTVLSKELIYAALQQVGPQYPELGTTTFCRPSETKSGQHRRWSAFLQQINLDDHVKFINIPAEEEAQGLTATLERYHNLWFEPSIKPAWQLVVANGRHLLFVYDHYITDGRGGTYILESILDALNSPKQELVNSSILEFTTDIKGFPEVDPIKRAPAPLSLFQAILNYLRFWAILLLYRKKHLFFHDVVIKDLKLDYNNPQKEANLVKTRLHSLRLDASTIQKCAQACRAHQTTFTSLLHTLIKVTLAADFYPQAKFNHSTTVVDIRSYLKPHDREKTMETAASIVSSWDWLPQFRQAGEQTASKDNTAFEANLLWELARKHRAHVLNDMNHRKTCFTAWQSVDLLGQDEEDYITGFIPGLKLCQRNAFSLSNLGAFRPNQSVGQDGRNADWTITNLEFSAGAYKTGYAANLVFNVAGVQDGPTTVHVCYEEGALSDDFVDSVLERIKMRMDAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFJ1</accession>
    <name>A0A1Q5TFJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFJ1"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="539" mass="59362" checksum="9F4D475863FBE7F3" modified="2017-04-12" version="1">MARTDPPAFTEADVLKEKGQEHIEEVVLARLTEEDLWKLSEESLTVWSWTGFRLGLIMFVHGCNQAGFGIDWGVISGINSLPAWHSYFGFGTSGGTYGLINALMSIGTVCGAPFMALADVIGRRGINFLGNAIVIFAAVLQGCAPNLPAFMAGRFFMGFGTALMSSSQYIGEISPIHLRGRMVGFFGACFQVGSLAMLGAMIGLSNLPGNACWRIPLILEAFFPAIVCLTIYVLTPESPRYYVMRGNRQKAKEVVAKYHTTSADINEPIVEIVVSQIEESLESDRTGFRAFWDYRVFFTKMARYRLLVLALYSIFQQWNGGSIITYYMVDALETVGITGTKQQLGINIGTTATYFVFTAVGALLVDKFRRRTLIFAGLITMVIFQTATTITSWQYSLHATHAAAGLTLLWIFSYQTASALLIATMHNLYPVEILSLPLRAKGMGLYSLIQGGASAVQTYGISVGIAKIGYKIWVVYIVYNTVQLILSYFIFPETSGLSLEEIDTVFETPGVPPVKMSLDIQKAKKERLAAARDEEARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFV6</accession>
    <name>A0A1Q5TFV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFV6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="76" mass="8476" checksum="1F2D9C5834DE5EBD" modified="2017-04-12" version="1">MIDHHLLGEDLPSVCGGASLQYSIPAIGLGEMTAVFTLHSMMGVCIRYSMPRISKILGFDSERRCDRTLPTWIYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGC3</accession>
    <name>A0A1Q5TGC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGC3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGC3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31315" checksum="EDEFF1558AC75B3A" modified="2017-04-12" version="1">MIEWLDLDFSETSPVKQVNWKDSLNEMIQGVEGCSHITFARPLEMPHRLWIIIQWLSETQRNEFHRTDTIASNAKKTLYQYSDNVHCSYRLDYSIGKIISAGFPYYLDPKLVHEVWMVYFPIYTLDAVKKQERQLPLLTDFYENYDESNPMTGIVSQDIAWLSGEINYHGVQCQRLVWFMKWKSKEAEELYKTTVRWVAGHEGKSSKVQLTINIFIDDLKSIAMVGYETWHAHFEDLRDVLGIRVFNHPALRGTGLGALKDTNELGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH39</accession>
    <name>A0A1Q5TH39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Free methionine-R-sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH39"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="134"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="237" mass="25501" checksum="14605C6AACF4A0D2" modified="2017-04-12" version="1">MPHADSSYFYGQTKEEVYSQLLDQAKGLLDGQRNWVSTFTSTSRDHLDALELRLATLSSEQQGTDSSASNLSNISSLLWHAYAALPSPSSAVNWAGFYIRDDKFPALASPISSPPLPGAPGLGGVTISTTYASHEDQILLLGPFHGKPACQQIRFGKGVCGTAAASQKTVIVPDVLQFPGHIACDADSRSEIVVPIIIRGETVAIIDIDCTLPSGFDEEDQKYLEKLADLLAESCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THY3</accession>
    <name>A0A1Q5THY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THY3"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53204" checksum="CFBFEBA0678A8545" modified="2017-04-12" version="1">MTLSKLFSKAAARAASTSAAAQTTKAAGDISSVFPSLRPDYQPEPLPPRFGDLKRRLFEKNEKALTESWKRLLPSLEEEVEKIRTKGSDIIPSVDYADVVSGTISEATMKEIRHRGTVVIRNVIPREKALDYKQRIRDYIAANKERVKAFPAESPAVYELYWTPSQAEARAHPNMLNTQRFLQRLWHSSDPKTKLSTSNPLTYSDRLRIRDPGDAKFALGPHVDGGSLERWEDAEYSSVYTKILEGNWEQYDAWDAKHRLNAKMDLYNGAGACSMLRFFQGWMSMSDTAPGEGSLHVCPMIVHSTAYTILRPFFDVNSQQPKLDATFPGSVPGACQEYNPVTHPELELETTMVSVPTVEPGDFVAWHCDMLHSVDKEHRGKSDSSVLYIPATPLCDMNIDYLLKQRQAAIDYSPPWDFPGAGGPGEFGFKGAMDWSALDAEGQRALGLGNKPWEITDDMSEGEKEAVQSANKACFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIK1</accession>
    <name>A0A1Q5TIK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000652">
        <property type="protein sequence ID" value="OKP00063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="20121" checksum="35DC696E41C0B867" modified="2017-04-12" version="1">MVSLGKSCWNLYCRLQPSILKYNIQFQNSDLLHLAARDNDYARAELLLLYGANANNFLHGKTPLMRAIQRGSLDVLELLLSHRNIDLRVQNREGESALTYAVQYGTCAGKGRLVNPQLDNKIRHEHDRTVPPVAICTGHIGFLPWLWIPFNDLRVKRGRDYRLKDWVRRAKSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIZ9</accession>
    <name>A0A1Q5TIZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000648">
        <property type="protein sequence ID" value="OKP00207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIZ9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIZ9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF7">
        <property type="entry name" value="CELLULOSE SYNTHASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="80"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="492" mass="54217" checksum="5EA2B73EEC708B6C" modified="2017-04-12" version="1">MATVRAACALDYPTSCFRVLVLDDGGSAALKQAVSDLQSQCIHVSYHSRGRQSGMVFAKSGNMNYALTTLQKEDPPEFCAILDADSVPSPDFLRATLPHLLQSPDAALVSTRQYFSNLPNGDPLSQTRSHFYTCQNAALDVLGLAIDAGSGAVFRRSAIVHVGLYPTFSFSEDWQLSQILHGMGWRTFQVQEPLQFGLVPDSLTGHCAQRNRWNIGHAQQIPAMLSSAYKHYTKSLRWSIICDGFGIVAGEAECFFGFLAVPLLFLSGQLIPTAHPSLVKAQILMSICQVAVMWIYEYLQAAINDFQSAPFAHLENKWLAGPNILAILRFYLVSAKPKGSSFVTGSVLNSWNQHALSACKKLYLDLWKNGVFYNLVLLVATVWAVSHAITSVMVGEEGRTITSLMTGIAFPPLVHICYLTLMVNWVPVAYILKPPHYPNRPSHPMEKDGKSTSRLRAKSDAASDFKWAAAGKVGKEILHLGTRLEIQERPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJE0</accession>
    <name>A0A1Q5TJE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoglucanase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJE0"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012682685" evidence="5">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="26154" checksum="106CF3E85743759E" modified="2017-04-12" version="1">MVLSKIASISTVLASASLVAGHGFVSSILANGQNYTGYIANSYPYMSDPPESVGWATTATDLGFEDGTEYQAPNIICHRNGTNGALSAAVTAGSKVEIQWTTWPDSHHGPVITYLASCNGDCNTVDKTTLKFFKIDEVGLIDDTTPPGTWATDQLIAAGNRWTVTIPSSISSGNYVMRHEIIALHSANNKDGAQNYPQCLNLQVTGGGSAAPEGTLGEALYTDSDPGILVNIYTALSSYVIPGPALYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJK4</accession>
    <name>A0A1Q5TJK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">PENSUB_7861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJK4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="223" mass="24756" checksum="86008900D7D2536F" modified="2017-04-12" version="1">MNSKQQLTVQFRSSLQSQASIISNNLISVTDHLSDHRDLLSSIVAYPGPEYPGRTQESMLQQLLRTKLDPRVEDWVARGRTAGTESSQSSRGFPGTIPNPSGPATTKQLSESELSELWNWAPIEANQEALQRNWGGNYTLEEREAGIQNVVTGLRRQLEDDDASEDEEEGDEDEGEDEMDVVGVHRKSGGGLEFEIAPHHPHAVTPVVPLDKILRYMTTGHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJQ8</accession>
    <name>A0A1Q5TJQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJQ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJQ8"/>
    <dbReference type="OrthoDB" id="4448468at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNF2 N-terminal" evidence="4">
        <location>
            <begin position="69"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="208" mass="23266" checksum="8F7C36D6656698D0" modified="2017-04-12" version="1">MALFDPLSQSHPAPTQNQLASGNSLSARSLPIKEVCEYAGISMTGPDSTPVSKVHWRLESETIIFHPWQPSAIAWVMAQEGIPIRSGILVDACVLGKTLSALCLTCFATMRKAQTHGQERTQRVKYRPSIIIVLASVIMQWVDQIDHLLKQKRNVMIFWGNSEHVSDTSRKERTVKYWDARRTNLGGLDVDDPETGCTVVITSYQTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL33</accession>
    <name>A0A1Q5TL33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein crb2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TL33"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17745">
        <property type="entry name" value="BRCT_p53bp1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000083">
        <property type="entry name" value="DNA damage repair protein (Rad9)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047249">
        <property type="entry name" value="BRCT_p53bp1-like_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013914">
        <property type="entry name" value="Rad9_Rad53-bd_dom_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08605">
        <property type="entry name" value="Rad9_Rad53_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="719"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1365" mass="149788" checksum="5923E176D57DD8E4" modified="2017-04-12" version="1">MDSAEAAPGDTQVVSQSVYDSIIRQNGESMYQGTSQNGADGATLRTLHEGDSGHINLLSQFDTARHEDNLSQDQDEESNYDENESSPMAYNPDFFPESQRFLATTPGTAVKVNQTPGTSMRTPSISRNPLAGEIESSGGMLALSQLFKATQAPSSPLVHTQQLELISDRPSPNLPIQHRRLTNAVSSPLIERPVHIARESSEPNLHYISLKDSQSRRDKTLGERLTRSANNMETSDDLDHEFYKESSFVENARRQRQIDEETAAQFAALNAPSGSTTGVATSPSHPTDELRPEETAHEAAGSEEETEQEDDIGPQVPQSQEIVQSSEEDKENYNGPPMSTEPASSAHDRLSQALAMDEHASMANQGADFPAQDSAPAALANNDHYIGRSSQVMVKDSQQTPYQSPKPDEHSSKPPSQHYDTSVDQMSDVAENSPVCPRLRSSPPGSQQKERSGSQHNTNTEMHTEEVIQATSSNEIRRVQSSNPSDRELPGPIPYGTQSGLETKSSSMPSRVTETPVHLRPQISDMTRMTSIPETSPNQTRPNEWEGESNGDGLNNEDDDLPPMFAVQSVNRRSRPGPSQTQSSPIKMIQAQEVQSQILSSPSGRQRRALTAIAASASPQVDHKVDWGLDFFTAEDDEFNALVIDGSPTRPRKRRRGNLGQALRPSDIVLPSTPRAHPPKTVAPSQPQSSAEKPPSNSQEMLAVHVPISTIYSQLDFSSRPFSRSASRPPARSTSRPASRSASRPPARSRSRPASRSASRPPSRSASRAASRAPSRPPSRRSENVWEVESPQRAVRRRSRSRPGRLMTSRDPPPQRIPVKFPDEKPPARPVVVHNPQPVFSSELTDVELLSDISMLSTSNITKSPSTTPQPHRTAPASTTDDSEIRAPNQVIAVWQGSKRAYYPGTCFGAPVGVTQGKYCVKFVDSLPVEVNKGVVKRLELRVGDTVKVEMPGFPKVAHVICGFSDRLSREEILRAAENGLYPQTDVHGYSAVLVASRQRNSLPNGTFNTPETLTKVPISRIYMDTNLWNRFKDREFTHKPDTAPLETTFRASSMRSSLPTSPNSRAARTGYDTAGIFSKMAFAVSYKENEASKNRITRLIRDNGGMLLNDGFTELFEPASVETPKKGDTIDGVSTVNSLSLDSDAAEIGFTCLIADTHSRREKYMQALALNIPCLSGRWVEDCVAKGRILDWDIYLLPAGESLYLNGATRSRIMAPTSPMESRLSDTIDSRPRLLDGKSVLIVMGRGKAEEKRKAYVFLTLALGASRVERVPDLETAKALLDSRVEASSASGWDYIYVDDADQTAAKSMLASSKSQPVNFVNGRKRRRSTVTMSRPDLTTLLGPQIVGSEFVCQSLILGRLYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TM72</accession>
    <name>A0A1Q5TM72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dynein light chain Tctex-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TM72"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TM72"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15170" checksum="A7AE9C515D8E6515" modified="2017-04-12" version="1">MAVEASPVFPVPTSELSKIITDACDAALKDVTEYEHDNVGTWNSQIINGVLKSLITATAPSESTKPTPYRFTVNSTIVQQGVIDKTAAADGSQSNAGKRGMHSASGAFWDVNRDGMWTFKYPGAEERGLDIVVSVTWFSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMH6</accession>
    <name>A0A1Q5TMH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcriptional regulatory protein RXT2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMH6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMH6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="553" mass="61819" checksum="CB08B09B57AFDAE0" modified="2017-04-12" version="1">MATQAALIADTIVGMKRALRREREDSGPDDAITQPTNRGNKMRANAKYVREGALGYINAEEFYKEVRGSLSDKRAAGGCWLRCAYLEGVQTNAEDLDCIQKIEHAGYTRHILQRNPIRYDSEGEELDEEDEDSEADVAAAEENPFSGIALESRPFTNLLQYRYEALTFQFSLAALLCPLKHPSELPVHPSLSHPYTSQALEQMTQAVEEKLRQEKALLWRARNLHRKFLGDGSWMPCGLVEMPDDRYIFQPWLVDDNKAASAGQQRQSVLGTSSAGGDLNGAQEVLSTAVPIEGQVGEGDVEMAEVPTAGNIEPQEPVTEFKSEETDAMVKDLPQHPAEEPDQGSEKNTTIVRNGVAETQEMITTKDGAQTNGEHPQHNEDNEDENEQDTEMHDGSSPEPPRRMTTRAQANANNDGNQSPLSADHSSFLQTPHPLFVIPENVRPDANFGLPPGEAEETRRLLWSYIQKQEETVRGFEHMLESLFRASHMKADVLEWCKAEGHVGEMSDGEDWYDREKWGLAEGEDLKKGTDEDEVETVDESRTTAKRGRGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMQ6</accession>
    <name>A0A1Q5TMQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMQ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMQ6"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP01472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="172" mass="19090" checksum="D277B4181345E6CB" modified="2017-04-12" version="1">MSRTRQPVNLQPQSTTETSRESSTLRLTGTLRLRAEDTPDTTAEPSPSRRIRWSEDVVDNEGMGKKSSKVCCIYHKARPVGESSSEESSSSSSDSDSESDTDRRNHMARHAHARGRRPSGENQADQSADAAATEGCCSDNHHPQKIKRRRRKPSPNAYEKMPKPSKSQPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ33</accession>
    <name>A0A1Q5TQ33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxynicotinate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ33"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF307">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP02348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="377" mass="41930" checksum="270A8DAD556C3054" modified="2017-04-12" version="1">MTDLQLGWGVSDLIHAQDVALEHIHVRRWEDGKLLATMPVNKTFGQQTVIHRADLHNALIEKALALPNVELRVNSLVTNVEFSPASVTLANGTIVRGDIVIGADGIKSTIRGHLLEDPSLKAIATGDAAYRIMLPRSMMEQDPELKSLIDEPQATRWLGPGRHIIAYPVRNHQLYNVVLLHPDRQEVEESWTTKGSKQAMVDNYAGWDPKITKLIDMVDDDEVLEWKLCLHRPLKTWVRGSVALIGDACHPMLPYVAQGAAQAVEDAAALGVLLSTISSRHDIPRALQVYEKSRKLRAETVQQSGSDNRITLHLPDGPEQVARDEQFRASTTGSNPDKWSDRETQRILWGWDAEKAALETWIGKIESSTEGKLNASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ56</accession>
    <name>A0A1Q5TQ56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c oxidase assembly factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ56"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="183" mass="20803" checksum="6C29D404FE3E1876" modified="2017-04-12" version="1">MLLPRALPRRPALFRVPRIRQTTPRRTLIPAPGPNTGPLMERRADRELPTINNSKGWLKSLPIFVVAVGAAMLGIFNYQKSSSSVVSSTLYALRTSPQAREILGDEIYFAQQIPWISGEMNQLHGRIDISFWVKGTKGQGKMRFKSVRPDRMSFFRTEVWSLETEDGTVVQLLDSDTDPFRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQE9</accession>
    <name>A0A1Q5TQE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_6998</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TQE9"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF58">
        <property type="entry name" value="METHYLESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012818522" description="pectinesterase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="70"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="427"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="792"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="13">
        <location>
            <begin position="1162"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP02465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1898" mass="199282" checksum="84BEC10E9BE3B40F" modified="2017-04-12" version="1">MLFASLLGLAGLATASAISTQPVYSTTSAFISETTVTSTSATTSYSKVPHKEDQAVYTNGLPNSASTTVVTVATDGSGEFTAIGAAISYAQSHAIPSVTVLAGTYTEGITISATPTVTVVGQTTAKDDYLQNQVVITNSGTVLTVNNNAQNVNFRNVNFVNTASAFGAMILKGNKYAFYDCQMVSTGTLGITASVGLGVISNSYIEALDKVIYGGANLYIYDTEIVPVDSSAILAYMKGTKDSSAKLWNSTVIFDRVTVTQKPGASNNYVYLGAANGPGMVVLYRNSVLGGLIAASGAHNDATTLDGYNNIAEYDNTGAGAYTSNAATRAGYVSLLSASDLLQYSISAIFEAAYPSYATSDTQWIDSSVLASIQAGDVITSLSSTTSTISVTSGALSASAVSTGLASSVVTSSSITSTSTAVTSTFVVNPTAGPYKKITAAIAALPNDGKEYTVYVMSGTYNEQISITRTGKTILRGETTYDNDYTQNTVTVEYSKGVLTSANEDETTPVVNAKNSDGKGLAIYNINFKNTYPKTTNTAALAADFYGNVQAFGCSFIGYQDTLLANKGTQVFSNCYVEGSIDFIWGFSTAYFYQSIVTTNTPGACVTAMSRSSSTAAGGYVFDNCLVTYTSTYGSTYQDTYLGRPYSEYSRVVYMNSYLDKHINPAGWNIWSTSSPQTDYVTFGEFNNTGPGSWSSSRASFATNLTATQAEDYTLSNFIGSTAWLDMDAYNYEPSYSLTGGASGTSSTGTSTSTGTSTSTGTSTIVTTSTATATWTHPSSGTVPPSGAVLVSVSGSVNGSYSNLTDALASLPDDTTTQVIFMYAGTYEEQVPSISRNGPVMIIGYINGNPGQSYADNEVTITFSRGLSVSPLPTGHSDAETATVSTASTKIAFYNVNIINSDNLDGSESSYVTLAASIYGNHVAFYGVYFQGWQDTLLTGSTTGYQYYESSYIEGAIDFIWGYSKAYFKGCTIGAKRAKSAITAQSRASSSAIGGYIFDQTLFTAATDATIDLTQTVYLGRPYSKYALVVVKNSYISDVINPSGWKVWSTTDPRTDYITFAEFNNSGPGNWESNVAAREAFGYATLLTEDTYALETVMDSTDWIDMTYWESIDTPTSVSGASVTSTPTSTATPSATATTVYDGTTPPSGAYIVSKTSLGTNTTVFDTIQSALDALPTSSKITPTVFIYPGTYEEQLVLNKSGTVILMGYSESTYDYSNNQVTIQYNHGIDTQADESNSNGATVYATGNYLQAFNINFVNNNGTAKDIATLGFAVKSSKYASLYGCQVKGNQDALLINGYLWMSNGYVEGNIDMIWGSGAAYFLNTTISPNEDDINLTADKRSSSTAAGGFVFDQCTITPATGAGSLSKISLGRPWNSYARVAYIDSYLDSCVEATGWEEWSSSSPQTSGVTFAEYGNYGPGSSTSGRASFATQLNNTGAVQFELDNFFGSTSWIVFTHIKGTPFVAGTSNSTTTSVVSTLLSTSTVPTSSSTSSLGAVTTTIDIVATSTVSLYSTITPVDRTSTVKSTITVTISPDVVSKFTTEKTTITSTQTISEPTITSTKTSILTVDIGSTVTPAVRTETSTLKSTATSTVTVTGKATTSTTKSTITSTLTVTAAASKVTSTEMQTTTSLKTVSAKSSLTTLTFTVTVGNGGTTTITTKATTEVVTSTSTKTATKTTTTTLSCEAAQAVQKMRKKRYILPRGDAATVTAYTTDIDYMTKIVTVTLPIATDIIAEITTQTVSLKASTITATITSVATKLSTTTIPAVTSIVTVVDTTSIGKTTTLKASTVTETVTSLVAKTATSTLPGETVSTVSLKMTTIKSTQTVPASTITTSKTTTVKSTTNLPAVTSTKVKITTVTNHPSVTVTERATSTSTKVEKTTSTTTEVATKTAKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQF5</accession>
    <name>A0A1Q5TQF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQF5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQF5"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="31922" checksum="4466E11F1DB1DFE1" modified="2017-04-12" version="1">MAITRVAVAGATGNLGPAIITQLLEAGFQVTILSRSNSHQVDSRVQVQVVDYNSLDSLVTALKGQDAVVNTLSVGIVPQDIHLRLVEAAQAAGVQRFVPSEFGGDTSNPLTSQLPVFGDKVAVIQRLQEVSKQDSAFTWTAVVSGPFFDWGLERSFIIDLKGPSTRIFDGGDVPVSSTTLAGVGRAVAGVLKYPEETRNRHVFVEEVQFTQNQLLKLSGNEGKIQREAVKTEDLEKQAYEALKQSPPDGRTFATSLILRAVYGGNYGALFTKTDNELLGVEKLSESDVANIVKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQN3</accession>
    <name>A0A1Q5TQN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQN3"/>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="189" mass="21762" checksum="6EAE943811663052" modified="2017-04-12" version="1">MVDERSSDLGDIAAEAASDFFTQLFGFVDTGVRRFFKNFYASFAEVSAKRWTKVIASVIFYLILRPYIERFFKYLHERERKKEKEKKEKEKAALGGKKAKMSANALRGGDKGGKVLGEVDNTDDEVEEEEEDELAQASGVPEWNGMARKRQKKYLKNLAKGQRAEKLSEEQIMELLDWSEEEEENKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU79</accession>
    <name>A0A1Q5TU79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Minichromosome loss protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_6790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TU79"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000790">
        <property type="entry name" value="Chromosome segregation protein (SepB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="10">
        <location>
            <begin position="57"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="14">
        <location>
            <begin position="386"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1 first WD40" evidence="13">
        <location>
            <begin position="601"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="12">
        <location>
            <begin position="1309"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP03781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1422" mass="155243" checksum="1BBFD5D2B09D36B9" modified="2017-04-12" version="1">MTEADPNPNGDYDLDNPITSTSGLRQGLTSYGDAHFSLFLRKVFIKALGYSEDALSRPIIGIINTFSGFNPCHANVPQLIEAAKRGVHLNGGLAVEFPTISVHESFSHPTSMFLRNLMSMDTEEMIKAQPLDACIMIGGCDKTVPAQLMGGISANKPILPLITGPMLPGSHRGQRIGACTDCRNNWAAFRAGEIDVEEIAAINEELAPTIGTCGVMGTASTMACVTAALGMMPLRGASAPAVSSARLRIAEETGANAVAVAKAHKKPQEILTKESFLNAITVLQAIGGSTNAVVHLLAIANRHPDLQGVITLQTIEEIGKKTPLLIDLKPSGDNYMNDFHNAGGMMALLQVLRPLLHLSAKTISGQTLGEVLDAASTKSLSFEQHIIRPLSNPLYPASSLAVLYGNLAPNGAVVKASASKYRSLLSHTGPAVVFENSADLALRIDDPELAVTKDSVLVLKGIGPIGNPGMPEAGLIPIPKKLAAAGLKDMLRLSDGRMSGTAGGTIILHISPEAALPGSPFGAVETGDFITCDLENRRLHLDVSDEILKSRIEERKQILESESGPVRARQQRRGYRGLYERSVNQAHEGTDFDFLTANDTPGTTVLAYTPDGRRVITGGSNSAIRIYTVDQDGEPKTVDGSIDGHFAIGATNETLLLGAEDGTVWSYDAVSGKMGGLLVRCALPVRDIAVSRDGVWAAVASDELTVKVVKIEDMTQVKYLREQGKGTKHVTFDPNGRYVAVSGTDGILYVYSLTNEEPEVVRKLDGVIRKLEPDAEATAKAVWHPDGTAFAVAEATRDISIYSISEWKKEKSFAGGHSGDITSLSWSPNGTMLVSAGADGRIVLWETKTQRIIQRYEFGNVLNLAWHPTKNSLSFTTSDGELFIYDNFVPKDHESQLQKPLQAAPIFPGPLTEISNNLPRTLAERSKESFQRPVRAGSPDSLDDILGEDEDMRDFVDDDDGAGYAEELNLFGKRPNGYLDELDGPDNKRVYTTPLPPKAHPPLQPGSTPWAGNRRYLCLNLTGAVWTVDQETHHTVTVEFYDRELHRDFHFTDPYQYDKACLNENGTLFSNNPSDGSPATIFYRPHETWTARADWRTQLPEGEMVRALALSESYIVAVTTKDYVRVYTLFGTPFRVYRQKSQAVTCAAWRDYIMTIGNGPIGADGRHATLQYTVENVKRDEICQNEDVVALPTGAQLQSVFFSDTGDPCIYDSTGVLVVLQHWRTPGQARWVPLLDTKQLSRLAGGRKEETYWPVAVAQQKFHCIILKGGDKHPYFPRPLLSEFDFQVPVSSNPPKDPDHEDAANDGSRFEESFVRGNILLSLFRDLISSTNATASQRAELARKELEIDKTLLQMLAVECREGEERGMKALELVTMMNDRNGKMMEAAAKVAQRYGRGVLEDKIRDMAERRIMGMGDDDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U388</accession>
    <name>A0A1Q5U388_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U388"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U388"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000057">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF885">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="348" mass="39271" checksum="F7CCB31A7ECE9735" modified="2017-04-12" version="1">MSETFSSVPQVDYSRLNNPSTRDDELKKLRDAIFVAGFLYLTNTGLEGLIRHTHEEIPRLFDLSDEVKEKCNMIHSPSFLGYTRLGAETTAAKTDIREQYDFGTPGMKDWTNQDPFWQRLEGPNQYPKYPGAQALVEEYIAKIDELAQSFVHLVAECLALPADTFDDFKGQMSRLKFVKYPRSAPNSQGVGPHKDSAGLFTFLSQDNTGGLQVLNKNGEWVDVPPIEGSLVINIQQGFEAITGGVCAATTHRVIAPTSQTRYSIPYFLGVRLDLTLKELKESATHIVHQIPVSDDRRKRAVDVPSEFLSPLYSCFGEAHLRNRILSHPDVGRRWYPELHAKYSQHILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4H6</accession>
    <name>A0A1Q5U4H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Transposon Tf2-1 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_5977</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5U4H6"/>
    <dbReference type="OrthoDB" id="4358334at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="20">
        <location>
            <begin position="1716"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="2021"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="85"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="428"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1992"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKP07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="2085" mass="236129" checksum="99B8991002C80A80" modified="2017-04-12" version="1">MSLSAKQLQRCILLGYQLATFFEFEDQHKELETPELQRQLQRLTADYDIPKLPKENPFPSDWLLRPELVKAIKEFRKLFDKIPASADSAESSQLPDPTPQPPPIRPRQTQAQSHSSPVTPTPFISRPPSPHSTSEELTDLSLEFGRSGSPDRSPHFEFSPQTLQDPPPPPRDPMENTRPFAMSEAQIAAIVTDAVTRALARNADEVRTIVDDVVTTRRDELRGPAGRDGHDAPQGNSHWKSDDVGYFTPDSSSDVHVRTTKGTTYYLNVYAFINQLKALVPLKSEEVVRANLPSCLREAAARWYSAELSDEERQDLSVRSLQLGWYATLERRFKPRPTEALTKVMSPSSVYSWRDVRAGRSVTEWAQNMLRDAQAADMTGTTTLLRLVWTRLEPALQRDIREPTAATTISQFMADLDQRYGQWYEMSKRARPRQTQPQPARYQGQQQRGPQFGGPRYGNDTRYGGPGFRAQLPFRPNYPGTDTPQLTWNPNRDSQQQRQPQWDVSVPPANTPQTQGQRPSYAPQQQNRPFQGQYHSRPQQQQQQQSPRDQSRTNQAGQLLLADKPWNQAGYSNTGYAARQPRDGTRPWGRPQTAAYMADPQEVPPSSDAPAPSDQPEANMANVAFYDGERIYDPQADAYYADDDYTSYAEYPPEEDPQAYWQAPPFPDDTGDQPCYNVVADEAEPTVTCLHCLTSFVSNNKLHAHLKDCAPKRTAAAVDDETVAYYVSPQATESPDALPQDLPVITSDKPRTSQPGMAYKTWRYASTVVGLTNQQKLLVACLDTGCVMTIIDADLAKSLNLPLQKCTPVPVAGIGSRHLSSAFVTFDVYFRGADNAARIQVEAHLVENLKAKLLIGMDIMGHEGFRLDFDTKTVRIPSCMNLSVPISTHAKPHHAAQRAVYAAEHTVIPPRSIIRVPTRVQTTLPEDRDYVFEGRHHQAAFYSHLVDANFAWVQAVNDTGEPVTVHRRDRIGTLYEADMPMACAVQPEVAELGRSPTEASPAHEGLRHTHDDGVRLPNGVTLYAGLAPDLIQQLTDVLMAYDVWGDHPGVVDIPEDQWMTIPLVPGWESKLPKSKIYPLGPKDRAVVDEAFQPLHNQGKMSYTTQHTATGFPVFVVWRTVHKPGREPERKGRAVVDLRPLNKVTERDVYPIPTMDDIILLTQGKRYITVLDAAKFFYQWRIRRDHRGRICVVSHRGQEMFHVAIMGFCNSVPYVQRQMDLLLKEFVDFCRAYLDDLVVASAAFDEHLRHLSMVLEVLERHHVSLEPSKAYVAFPEVSLLGQVVDAFGMSTPEDKVKAIANLQFPVTLRQLETYLGMTGALRQYVPFYAQKSEPLQIRKTELLRGSPVKGRPRQEWSSRTRYTHPTERELAAFDAIQAVFQDPQWLVHWDRTRRLYFDIDSSQEGGHGAMVFHVKRSYNHTNFKAVPPSTAVEPILFLSRLLTPAEKHYWSTELEVSCIVWVVRKIRHMIEAAPDDLTPVAYTDHIATINLATSLSSSSPDRMNLRLVRASQYLQQYRLLVYHKAGKLNCVADALSRLAAVDKAEPREDDDLDALYVTTASDLHLPGAAATWDVPDEAYAFLTSCVQLSDDFKSRVRAAYDSDPKWSLVLAELERIERDPDPVKPRLPYEVDDGLLYSKQADGDFWLCIPDSMKNDIFEIAHGEGHLGFHRAWQKMRGFVVHKGAKKLRAYIDQCDECRKNAVPRHKPYGSLQPILAPPMPFHTLTIDFVTGLPRTKKGFDAVAIYTCKSTKRLGSTPGKKDWTGFQWATAVLRDLQKGDWGVPVVWISDRDKRFVTGFWKGLFTALRTKLLYTAAYHPSADGQSERSNQTAEIWLRHWQNLHQNVDWDEGLAPMQASLNASVNASTGDTPHRLMFGVHLRMPWNLLRHAFVGSPHAARQDADECAKYAAMVMKKQYDNRHKPIFFKKDDFVYLRLQQGTDPGYVLPTRDITKKLTQRHIKCRVLERVGRLAYRLQLPPQFAGAHPVVSVEHLERAPEDSEMPPTQPPSTFDPRFPEDTDRADVDAVLDMRSRGRGRNRRKQYLVRWSGVGNDHLEWLDEGNLLGAEEKVFEYLRDVLHHEQGSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4Q9</accession>
    <name>A0A1Q5U4Q9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4Q9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4Q9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="304" mass="33794" checksum="3CD35EFADB8071BB" modified="2017-04-12" version="1">MGEKDFWSTETYEAVASFVPHFADTLVQSIEFSPTDRVLDIGCGDGKFTTSFSPVVGYVMGVDSSPAMIEAAKKLDYGGAVTDFRVVDCRLLNKEVDIVNGNWDKVASNAALHWVLRDPTTRVSTLETVFRSLKPGGTFFFEMCGFGNAPEMVTSYIFALVNHGIPIEKAEEMCPWFHPSDDYMKGLLEDIGFQVQKIDLKPKPLKMNPEINGGLEGFMGLLGAPWLDLLDTEEKKKSALKQMCRMLRHGTTKEDGTLPVITPIVLVEHSQGEPSTCASEVYHRAQGRTFSRNKGTRSHRVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U720</accession>
    <name>A0A1Q5U720_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U720"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="15761" checksum="3685D00EFC703B93" modified="2017-04-12" version="1">MFVIPAEQLDEFDRDPFLQELGHTIYSYPERSCTIIAWEPSPQPPQVDHQHDVNKPPGVPALQSRTRDPLAARACGWQPLRLFVIRHIVSITPINIQKIISTTHKAAAPHNPSEGAEATTAVNNMCIWGPMEQDSESDTGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U796</accession>
    <name>A0A1Q5U796_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U796"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42671" checksum="8AC662D4182C649D" modified="2017-04-12" version="1">MVQHWQVIAPARKETTGVLGEWMDALASNSAGGLVPLLAVPLNAHREQIDGFVPGENAEDNEDGDFICSKQTRRDGLSQNHSGKAARIERHNATEISMTSPKSLLNFPSTIHHQIFSYLDFVEDVLRFSLTNRYFWAVGLSHIEDHIINSLAPWAGEKIMCVSDKSDPHDFPPGLLNATQAEEVRELNKVYDLNSFSIRNTYKKIGGPPLSQRLQRWFLDYEASHYMGSANRAEIMMGLKPEILEFYPRDQRWILRNLTTREYVRGEVIALKEEFIHGPQIEVFGFAEVLISRISWSSEPEKIGGGDHITRGKWAGHRFDITPLAWLQEKHGMEGWRDVSNEILREIDLTLGGQLGDDWRDQMARNYGEACEAGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U848</accession>
    <name>A0A1Q5U848_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Versicolorin B desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_5593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U848"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U848"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="10509" checksum="AE49138BFB98EF3A" modified="2017-04-12" version="1">MLVENAKIRIETHRQAAILYFAVWSVYSLYFHPLSRCPGPKLAAISPIIHILWDIRGKEHSVIKRLHDQYGSVVRIAPNALVYNSAAAWKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA09</accession>
    <name>A0A1Q5UA09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA09"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="42066" checksum="0888612931D7CC87" modified="2017-04-12" version="1">MVMTLLHRRILCRWALRISLEASFSSINGAGGFSISPKFEFRAIVPIHSEVSSALSGAEKSLKSRDVSAVIKDAQRALFEAFRGGKASKSDALGNGDTILHVVTRWQGHSYRWDPRSRLTWRSVINSLLQASLSPNRPNDRDQTPADSMIDYIGHEGGDMNKQQVDGRRNDHLFEDFSFRLIWKIADEKGLQDIDLPEEMQPLVYKSGKLLAAQLRKGTDIHRWIESYTRWGPGLALILQSGYTPPVGAVRAACEANYQLCIGIDTLQNVNAYEAYTLLAATSANLEGLSERPRWSVFDCVGVNLDLADQLWDSGFRDVNAIDKKNETCLTKLWENTPPCDLDVFLQKAHWLISKGADIRTTTPLDQLCMPWETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAH0</accession>
    <name>A0A1Q5UAH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000519">
        <property type="protein sequence ID" value="OKP09468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAH0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAH0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63282" checksum="BDF334B3890C5081" modified="2017-04-12" version="1">MASRKKQNNTRKRDGIHFVNARPTSETERLKAQKLVRAHVGRWISDQTKDRSAASEQSSISAPRSSRTSISTSTSTDNAGPSSFPLVSRPPPYVAQRTLTIGASTSHPPQRDWQPRSSIATSQLNDSSECNGSDDAAEVTNFGEPVTVIPWNEVTRIEPVISGFLDPFGQHPSNFAPEVVNMCESYYPALFTAFMFGSLCHQRVQWLKGWVPGSTFGPKQQRILQQCEMESIKLISQAVRDPTRAVSDAVLLSVICMAHHQALEESPDQYRKTPFTPPFQRLQWLDVYGHLPPNMIHIHGLVQLLKLRGGLKNIKLHGLRPTICFSDIMTASCFGIAPGFEFCAIDESRSNLSIQDLLGFGPYQIDHSFRWLEQLGLTPQIVEAMTAAVTYVDIMKTCMKSSHDVSLLSDQRNLTQYTLLSVPPAADLQSTSTSTFSQPIEEAAYEACRLAMLIFAVGVVFPIPANNTPLPGLAQRLQAVLKRPEAAEMYTSVNHCVLLIWVLTLGGIAAWDSPAERAFFGSALIEVTRRTGLTAWNDVKRAMDVMLWYDIACDEAGEAFFVEAQSSYVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAH4</accession>
    <name>A0A1Q5UAH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000511">
        <property type="protein sequence ID" value="OKP09484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="134" mass="14986" checksum="C60B5F7CF46C2811" modified="2017-04-12" version="1">MADTYLSEDAKKLLDDLALALRSVKTQDDGNGNLEYEHKSAKPFVEPILKTIGLPDWNFTVWMWNTSFKWQELPGPVNIIPICNITESARSEPGGALKFGLMRRIDGKVTVEPRLTAIFAVPPIARYVDARARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC17</accession>
    <name>A0A1Q5UC17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000400">
        <property type="protein sequence ID" value="OKP10025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC17"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="8029" checksum="76034DEA98B626FD" modified="2017-04-12" version="1">MASPSNTIIIADDEELPSLEPGSSRPQRAPRRDYSYRDFESMIVEAVDDETESTPSRKRKRVETKESSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDI2</accession>
    <name>A0A1Q5UDI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit beta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDI2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDI2"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="765"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="833" mass="93010" checksum="82EB478E1C087AD7" modified="2017-04-12" version="1">METISRISSMLETARELTLEAAQSAASNRSSNIDYNSRTYSVPHINKLLDSRHEREVLDGMRKVISLMYRSEPSLTFFSAVVKNALSANLEVKKLVYIYLVHHAEAEPDLALLSINAIQKSLTDQNPQVRTMALRTMSGIRVPVISQIVSLAIKRGCGDMSPHVRKAAALAIPKCYRLDPNTLPQLTGYISTLLGDPQYFVVGPAVSAFLEVCPEQIDLIHKHYRSLVKKLVDMDEWGQLATLRLLTIYSRKCFPRRTQKVKQAVTSKSFYDDEEQGQIDPGDGPEYEVQIIDPDLELLLRACKLLLQNRNSAVIVSVVRCFFYLGTPEYLNAAIGPLVALLRSPQDMQLIALYNIVTVALRDPKPFTKYIARFLVHANDPPHIWRLKLEILTIIFPHCGKHWKGVVISELEHFSKGTDPELVRESVRAIGRCAQGDATTADMCLRILLDQISSLDGNLVSESLTVIRHLIQQDPPSHKQTVIKLVTHLGTTTNPDARATIIWLVGEFAGADPGHNIAPDVLRILIQGFADETEVVKQQIVLLGAKVYLHHLLQNAPPESSEPVSSNPETATNLGQAIHNEWTEEQKEEKKSFDEPQQPEDAKEESEDRITLLWRYILLLARYDTSYDLRDRARLYKALLATPSSTQLANLLLLAPKPVPHAPSPSETRKDLLIGTATLVVGQDAGYHGLRGYSNLPDWVESGKEPDASLRTEDIKPETTTLQSSMTAGARLDKALREHETIVPPRRNGAAPAGGPSGRKTLDQWLDEEEEETDSETETEGETDSEEETDSEEDSDEDSEEDDSEDEDVEDEEEEETDSETEAVHKEAQQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDX8</accession>
    <name>A0A1Q5UDX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDX8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="195" mass="21594" checksum="9A8F61F951F99F46" modified="2017-04-12" version="1">MIGHDLSETDFSLLLDQSFGLAEDPVIAPPEPPIFEPPPETPEEKEPSPPALPPVPPPAPPARFYDSRELGQEDINAFAASHGYTLTVRRSDPTKVDLVCSRWPNPARERKTNGTNCPFRLQFRKRAGAPQKPGYIILSDDPPPQAGWELRIQNGEHNHWPQAPAKKKRKKSEISGSSKPQESPSTNVECSQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE15</accession>
    <name>A0A1Q5UE15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_4019</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE15"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE15"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08641">
        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="563"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="928"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="941"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP10716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1007" mass="113959" checksum="8A71C09C27372A77" modified="2017-04-12" version="1">MDASEPYLTNAKAFAALSCPTKPRKWVKRSGWTKYNADGSSEPVDAPNEEMLTFDTEVMYKDNPFAVMACAVSPTAWYAWLSPWLLGESQEKVQLIPLGDPSQPRIVVGHNIGYDRARVLEEYDLKQTRNFFLDTMSLHVAVNGMCSQQRPTWMRHKKNKDLRDKIASEHNSVELAALLENNMLREEEEELWVGRSSVNSLRDVAKFHCDVTIDKAQRDFFGELDRGTLLTKLDELLDYCAADVAITHQVFRKVFPNFLETCPHPVSFGALRHLSSIILPVNQSWQEYLTRAEETYHKRLDDVQRKLLELCDEALKVKAEPDVYTSDPWLQQLDWSGQEIKMVKGKKKGDPPRPAARQKKPGMPKWYKDLFPSSNADINLTVRTRIAPILLKLSWDGYPLVWSDKYGWTFRVPRDQVKKYENQPVVVCNMAEEEKNLQLRDDRKNTYFKIPHKDGPQARCTNPLGKGYMQYFERGILSSQFALAKEALEMNASCSYWISARDRIMGQMVVYEDQTQKNGSAQNPIDNRLGFILPQVIPMGTITRRAVENTWLTASNAKSNRVGSELKAMIKAPPGHVFVGADVDSQELWIASLVGDAPFQLHGGNAIGFMTLEGSKAAGTDLHSRSASILGISRNDAKVFNYGRIYGAGVKFAATLLRQFNPSLTERQTQETAANLYKETKGTRTSRRALSETPFWRGGTESFVFNKLEEFADQERPRTPALGAGITEALMRRFINKGSFMTSRINWAIQSSGVDYLHLLIVGMDYLIRRFNIQARLSITVHDEIRYLVKDEDKYRAALALQIANVWTRAIFSQQVGIDDLPQSCAYFSAVDIDHVLRKEVDMDCITPSHPYKIPHGETLDISQLLAKNEAAFLDPSIVPISPPNPEKYDYTPRESVMSTLQASNDPAFIKAQITKDDKELREIIREKAQAASAGKPTPPRSSASKSRSKSTGWVSAEPQRAVLMDMESGLYPDFRNPRPSSNGNSKQQHQVGMYRSSWKPRPTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEA4</accession>
    <name>A0A1Q5UEA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_3617</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEA4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="486" mass="52979" checksum="A3FE1C3347F3D33A" modified="2017-04-12" version="1">MGQMSAVASVRAEWRAIVICLFITIAAFQFGFDSSYYSGILAMEPFIKAYGHYDTATGGYILSSSIQSLTTSIINAGEFVGAISSFLVDNKFGRRGGLFVSSAFVVIGTIFQVAADNLGLLITGRLLLGYAVGLISCLVPLYVADCAPARFRGALVSLYQFNIGLGLLLGVIVDNSTKHRNDSGSYRIPMAVQLIFPIILVPGLLTFAPESPRWLLSRGKIEQARESLLRLRGDRPDLIESEMTYLTGLVEEERRVEGSWGDLLKWNVDGRKAYLGIALQAWQQGSGINFITSYGIVFFSTIGITNSFLIQIGLYLVAMPAVWLNQYCVERFGRRLMLLLSCGMVATVLLIVGGAGTAPSKTLALDRTIVGMVYIFMVVFNLALGPAVWVVTSEISTGPNRGKLMATSTATNWFCSWMVTFTFPYLFNADAAGLSAQVGFIYGSLMVAATVWVFFFLPETSGQALEEIQILFQKGVPAREFKCKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF92</accession>
    <name>A0A1Q5UF92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase 2C-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000298">
        <property type="protein sequence ID" value="OKP11137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF92"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF92"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000098">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF589">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="461" mass="50429" checksum="14177C25D9EA6658" modified="2017-04-12" version="1">MTVVRIPLRSAKHHFGAVTARGTRPRNEDTYQAGVIDVPAFAKRPPASLTIKRSNSPNSSRESRAADTANGDPQVFYFGIFDGHGGSECSTFLQENLHEYIQNSAADFELQSSLRTNQQRVSCGEAAATSVTTSTLPVMQEANRKRIGDLEKSLVQNWRQLVGGYFKRFKPPQFSYYGPDNSTENAASKGYVAIEEVMEYAFLRADLDFVKAQAAKRDDDLALAEKPLNEDEILHSPSLTRTPKIGGRSRFKGGSTGSIALISTPSPTPFWHPAGPSSLLVAHVGDTRILLCSTLTGQAVPLTSNHHPSSPIEAGRLRRYAATFVTDSFGEERMSGLANTRAFGDVQSKRIGVSAEPELCRVEMGPAEFSFMVMVSDGISGTLLDQEIVDIVKEARTPEQGARDVVSFATEVTREGDNATCLVIRLGGWERRLEGGVGSLGTKESREWRRQDATDPRRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG27</accession>
    <name>A0A1Q5UG27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG27"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG27"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="143" mass="15834" checksum="01FF903609470FA9" modified="2017-04-12" version="1">MGISGPIASEDNSYRTDFLLRTPASRRSSTGGRSMLYRTNSRIRSLFFGQPRTDKDVPPVPEVQVQQCPATPPCQRQPSTESIKVYSPPGAFSQSRKFLGPEPYPGTISRPDTTFTDLVQAVGFNDSKGNPSYKLSEFKEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGA9</accession>
    <name>A0A1Q5UGA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein translation factor sui1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGA9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="26286" checksum="0D0BB03901296AA0" modified="2017-04-12" version="1">MASNKDMRRADLGEVSFVFSLQTWLAESSEQKKTAATPAYMSVFMSYPFAEADEDAGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVADTEMGEVIQLQGDQRKDVQEFLTDKKEGLELDAKTIKRNLRNPKPPLNIPLLSHTPNNGRRPSLPSHPRPDMQQLSQKGKRTSQPPPRRRQRAQRPAYQQRDVPPAVNTQDDRYSRMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGJ7</accession>
    <name>A0A1Q5UGJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGJ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000181">
        <property type="entry name" value="NmrA-like family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="33386" checksum="6F6E367510E0D429" modified="2017-04-12" version="1">MSKQIIVVFGATGKQGGSVVSSLLSDSAAGKFHVRAITRDVTKASAKALALKGAEIVAADLSDGESIQKALKGAYGVYAVTNYWDHHSAELEFAQGKNIADACKKEGIQHLVWSSLLNVTKLSGGILSQVHHFDSKAKVEEYIRSEGIPATFMLPGFYMSNIPGGNLRKTPEGTWKLALPIPGDSPIPLFASEYDTGKFVKGILLKRDETLGKRIYAATKYYTPLEILATFKDEYPNAGKVAVFSELPHAVFKGILAAAGMPEVAQEELLENMRLMPEFGYYGGEALDSSVDSGGCRPGEKWVSAASTSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGZ4</accession>
    <name>A0A1Q5UGZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGZ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGZ4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="303" mass="33026" checksum="FC4AF8933AFD9250" modified="2017-04-12" version="1">MLYKTVEVDVENIGGQTLWSYAAQNGHKAVIKLLLEKGARIEAKDNSGRAPLLYASENGHAVIKLLLEYGADTCSENPDGRTPLLLATLHNYQSIIKLLVERNASVVSVDKYGDTPLRWARINESEAAAILLLEKDTEEDSRHSSRLGIADPNSKVRLAPVLLVSAVLKGHQTVAKLLLENSADINSADRSGRTLLKGDQMLVKLLLENGADANSEDGFGWTPLVSAALKGHHTVVKLLLDNGAKINSEDGLGRMLLLYAAVNGCEEVKLFLKRNAEVIVTIAFIVWRYREEPLASDAAEDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHA4</accession>
    <name>A0A1Q5UHA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000270">
        <property type="protein sequence ID" value="OKP11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHA4"/>
    <dbReference type="OrthoDB" id="4363188at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="170" mass="19000" checksum="9E39F88CF1CCD0C4" modified="2017-04-12" version="1">MANRITKTPTFRPGHYAAKLAKALEDEAKAKNRSRHKDAAGCESKSSGSIQMGPESHNGSKVIHQSDRETELVDSSPDRLHQSTTHANNRPSEQVKQGPFKALSERAKQMERGREWESNAAKRLLKRELAGEIEILKGEMEDLKQMVISLQPLLSERSRGKRVAFQDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHH3</accession>
    <name>A0A1Q5UHH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHH3"/>
    <dbReference type="OrthoDB" id="3440282at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012389128" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="31035" checksum="83AF0AE4E1830CA8" modified="2017-04-12" version="1">MKIATFWASFALLVPRAIAISATSTTSATSTAAAATCTASLIASLCHYTDPGPEFAVAIESRASCWDYCNAHPPCNFVIFNAGNPYLGTGTCWLYPGETYDPSKGSSSCTEPNGDLSVYSKPVCSGGSATTTAGGCAATATPSAIASVCGYPPPDDDCFYDCTASLGAPDCLSQCAKADSCSYVVFNSHNPSDSPYASGTCWMYPNGTFNAGSATTCSGAPDQFVYKNLCPKPLTSSSSHSSSALGSTGTGTAGTIPGSTASTTTGSNGTATAAGNATGSTTTNKNSAPGGLSLPNPFAAGVALLIWLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHK6</accession>
    <name>A0A1Q5UHK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_2522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHK6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHK6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012863740" evidence="10">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="108"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="443" mass="48322" checksum="1E2EA59A6EB84A49" modified="2017-04-12" version="1">MHPHQILVILAILAGLAYSLHGPIELNNAIEEPVTSQDQSESLRLKLRGVTKQLDYQCGPSYGSCPSGTCCSSADKSPVGPPTKEIPRPHIGRVPYGPQEIRSCTVPGTIALTFDDGPTRYTGDLLDLLDRYDAPATFFVTGINNGKGPIDDPSLPWAELIERMIISGHQVASHTWSHEDLSKVTPEQRADQMLKNEVALRNILGSFPTYMRPPYSSCLPGSGCREDLGDFGYHIVLYDFDTDDYKNDSPNLIQLSKDIFDRFLNAGNSKINSWLIIAHDAHEQTVHNLTEHMLKTSKRLGYRPVTVGDCLRDPRDNWYRADSTWVGQKNKKKTPKKGPKKSNVPQQVSVDGTCGANYTCLGSRFGLCCGSNNVCGNTTTHCGHGCKKEAGYCAIHVPPNGDAWDPVSPGGKAAKSEADSNVRVVGTAAATSLVLALIVAMWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHX5</accession>
    <name>A0A1Q5UHX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="10121" checksum="6880B436B913B91E" modified="2017-04-12" version="1">MLQILRRNANLASAIAVLVEAKHAVFDPSRVTPVDGCARATGCLATATILGTIGLAGAGLENSGVCHGEEGDEGSHSSTADLHFEDSEKSQGKRKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI62</accession>
    <name>A0A1Q5UI62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease MAL61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI62"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="61"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="535" mass="59059" checksum="F4C6FEB79421A01D" modified="2017-04-12" version="1">MSTDIQNTPDSESVRGEKHHVLHSEKVTTSDLMGDAFDGENREHEMGVWEAAKSHPWACLWAFVMCFTIVMESFDMFLNGNFVALGAFQRKYGVLLDAATDTYAIPTRWQSALFQAGQCGAFVGVLAAGPITDRLGYRWTTLLALVLMNATIFISFFADSLAVLTVGQALEGVPWGFFIANSPAYASEIVPLALRGACTATLQMSWSIGGIIVAAATYGYNQRNDEWAWRVPLALQWIFPTPLMILVFLAPESPWWLIRHGRKDEALRSIKRLGTGDPEKAQQTFAMVQRTVEIEAQMGGNAKFFDMFKGTDLRRTIIICLMYASQNLAGNLIANQATFFFEQAGISSNRSFELSLINSCLGFVANVCSWPITAWFGRRTIYLWGTAANILLLIILGICASIPQNSSTNYAQACLGIIISFVFAGTLGPISYTVISETSSVRLRALSTGLGRAAYYVVEIPMIYLASQMLNTTGWDLAGKCGYVWAGTACVCWVGAYLGLPELKHRTYRESDILFNRNISARKFKSTVISVTENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIA8</accession>
    <name>A0A1Q5UIA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIA8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="353" mass="38924" checksum="43D0AF0B4D5E6066" modified="2017-04-12" version="1">MFWMMIVARGIAGFGAGGEYPVCATSATEAADETAQLRQRRGFLVAVTTDFAVDLGFVAAGLVALIVLACYHQQNSEGVWRVSFGLGFILPVAVCFFRVRMINSTQYRKHAIKSNYPYWLVLRRYWKPMLGTSLAWFCYDFVTYPFGLFSSTIVEQLNPNNTTVQNIGYGTVINSFYLPGCLLGGWLMDRIGRKQTMTLGFMLWAIWGFILGGALHPIQSVFPLFVVMYGIFQALGEMGPGVATFLCAAESFPTPLRGHFLGFAAAVGKAGASIGTQVFTPIQNSFESTEKGQQAVFLIGAAFTVVGGLIAWFLIPDMSRELETEDARFKAYLQENGYDFDLYGEALVVNRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJA0</accession>
    <name>A0A1Q5UJA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectin lyase</fullName>
            <ecNumber evidence="4">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJA0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012140656" description="pectin lyase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="32372" checksum="98FB5659059455ED" modified="2017-04-12" version="1">MRLNSIVLFAASAMAQCALKRTDTISVTGSAPGFAYGVTGGGDATPVYPTNTSHLIDLLGSDEPQVIIVDRTYDFIGTEGTTKGTICKSWGSFEDGCQAIIDTGSGCGDTGSESYEWDTAGVTGIYVHSNKTIIGVGSEGVLLGKGLRMVDVSNIIVQNIMITDLNPKLVWGDNYIYRTSGRSPALSGSTLFHAVNSVWENNNGHAIEGTDNGQGLFEGCVFNNVSQIVVDGFVGQLFSSSGGTANKACYDYLGRDCVGNIQVNDGSSFTKADTGFFSNFTGLNIASPSAASAAQTSVPTNAGNTLQNGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK37</accession>
    <name>A0A1Q5UK37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK37"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK37"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16514" checksum="2B9B487A0FD840B6" modified="2017-04-12" version="1">MSSFHSHPLGIVTLVAHFVQCAVLTPVAFALSTGFSCVSRHHSWHVVPLYLTDTVLSYLWLTSFIFLAQNFNQTNCSFSRWNGEVVCSRQYAAEAFAFIAFGSFVTLGSLLFQFFYAYTYRPQFALPGEEQRAKENLHGNLETAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKJ2</accession>
    <name>A0A1Q5UKJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antifungal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKJ2"/>
    <dbReference type="SMR" id="A0A1Q5UKJ2"/>
    <dbReference type="OrthoDB" id="4478077at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.60">
        <property type="entry name" value="Antifungal protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023112">
        <property type="entry name" value="Antifungal-protein_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022706">
        <property type="entry name" value="Antifungal_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11402">
        <property type="entry name" value="Antifungal_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57598">
        <property type="entry name" value="Antifungal protein (AGAFP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="2" id="KW-0295">Fungicide</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013361741" evidence="3">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="92" mass="9925" checksum="91A48C75F4A90FEA" modified="2017-04-12" version="1">MQITSIAIVLFAAMGAVANPTATESDGLDARDVELSKYGGECSLAHNTCTYLKGGKNQVVACGTAANKRCKTDRHHCEYDEYHKMVDCQTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKN5</accession>
    <name>A0A1Q5UKN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein bms1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_1113</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKN5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKN5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="62"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="648"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135859" checksum="1EEAC72FB06E06C3" modified="2017-04-12" version="1">MEQQSNRTHRPAKEKKKFEGSNPKAFAYSNPGKLNRQAARSHDVKEKRLHVPQVDRMPEEAPPTVVAIVGPSGVGKTTLLKSLIRRYTKQTLSSPQGPLTVVTTKRKRLTFLECPSDSLAAMIDVAKIADIVLLMIDGNYGFEMETMEFLNALSTSGMPGNVFGILTHLDLFKKQSTLRMTKKRLKHRFWSELYQGAKLFYLSGVINGRYPDREVHNLSRFLSVMKNPRPLIWRNSHPYALADRFLDITPPTQIEENPKCDRTVALYGYLRGTNFPAQGARVHVPGVGDLTVSGIEGLPDPCPTPYMDQQIAKATGKSSRRKLGEKQKLLFAPMSDVGGVLVDKDAVYIDIKTNTFDRDSDEESDDENRGLGEQLVVGLQGERRLLGEADEGIRLFRGGEKIAQGDEAEETGRKHKRQARIADGERVTELNSDDEEGLDSDEDDEELGDDQDEDDDFSGDEEDEIDVSAPADFESSFKERQNGKSNGEDGDVAFADSDSDLGSISSVEDQELDSGDEDEEDDGEEGEDDEDDEGNARWKDNMLANAKALHGKRPAFRVNDLSRMIYDESITPIDVVQLWRGEADDEDEEESDIEADEDGEDFFKKTDNEKRDQADFRAVPEYDYEELERKWRDEELIESLRRRFVTAKLGGGGSDDDLEEGDLDDLDSDDEGDGAFEDLETGEVFDGFDDDEDKDGDEDEDEGDEKEPEGPVDLDAERERNAKRKEELKLRFEEEDREGFANAKDGNRDGLEGEFGEDDWYDLQKAKMQKQLDINRAEFDELDPASRARAEGYKAGTYARIVLENVPYEFASKFNPRFPVIVGGLAPTEDRFGYVQIRIKRHRWHKKILKSNDPLIFSLGWRRFQSLPIYSTSDSRTRNRMLKYTPEHMHCFGVFYGPLVAPNTGFCCVQSFSNKTPGFRIAATGVVLSVDEHTEIVKKLKLTGVPYKIFKNTAFIKDMFNSSLEIAKFEGASIKTVSGIRGQIKRALSKPEGYFRATFEDKILMSDIVFLRAWYPIKPHRFYNPVTNLLDQEEGGTADSGWQGMRLTGEVRRDQGIPTPMNKDSAYRKIERQERHFNPLRVPKQLAAELPFKSQITKMKKHTDKTYMQKRAVVLGGEEKKARDLMQKLTTMRNEKSAKRAAKQEERRKVYRAKVADSLEKKTAREKRERNDYWRREGKKRKNDDESGGGRGKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKQ7</accession>
    <name>A0A1Q5UKQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKQ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKQ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="183" mass="20082" checksum="11800FB352EE1E2A" modified="2017-04-12" version="1">MGFSKQYKNIIAVSSLSKAYALPGIHIGWAISPNPEIIEQITLARDYTTLSVSQIDHDIATFTRGLGIENGPLGRSWEICRTNLASLEKFIASYPDHLRWVKPTGASMACVCIIETQTGLPLDDACYCEGLLKETGLLLVPGGKTFGTEGDDDFKGYIRVRFSVAPESFGCALKIWGEYLNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULI2</accession>
    <name>A0A1Q5ULI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin-like protease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1034</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULI2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULI2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012569937" evidence="9">
        <location>
            <begin position="19"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="730"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="782"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1245" mass="131790" checksum="71E2C2A1A1FDFB07" modified="2017-04-12" version="1">MRLLSSSAFSLLVPAALAVTPTLTPGDISTAATKPRTTYGSSAHPGSTGLTSTKTRSISSETSTTISGTTSTSISSDTSTSISISSTTSTTHLSTITTILATTQYSVQPVDATNTATTAFLTTTTATDGHVVPFIFVPAAALGAEAAGVAGAVGGAVGEGVGIFGGFLADLGLGGLVEAFHFPSLAGIVLGQAIDYKASPTATDDSHTSKTTKSTSSTSSTSTSTSSSAPTASATPWIVQSKSGTSNFLFKNLLKEKVENYDSGTFISFPNFDLFIVSLNSTTAQSLSEESMVRSVEENSVNESSDFEKASPYNGNAKREVLKTRDQAVEKRAETVTLTETPGFVATAAPQAAHLFSQVDSPVHLKMLSDPSKGTSKDKDVLDYTFQSSLGKGTYVYVLDTGVRRSHEDFQQNPVENVATGYDPKDTEGHGTRMADLVGGAWAGVAKNAKVVNVKFGSSDIGNPVELRSRIYSAWAAILSDVEGNKRQGKAVISLSSGWDSYVMYANGVFLSAEEEEQRLKYTIFNTLLDESFKLGITVLVAAGNQGKYGVDISQRAPAGLAQPGYYPALIVVGSVNSKGVISPFTNKDKEGAITIYTNGEDIIAADYRSDNGWSIASGTSEATAQVAGLVAYFLGRSDLQERLQQGGLGQVAQNVKKYLISQGQRYTSGGPLIANNGELVAVQAEIQGSSCEFQQGSSQNARRVKRDAGFTLSTIAFTKEYEMVCTRSVTSTSSSTQTASVTSDSHSSSTASGPTDTSKASTISGELTKSTHSTETKQTEVSKTSTSSTKSTHSTETKQTGASETSTAQKTTTLVTTTSTKSIHSTTTGHSESSTSSSTKSSASYQPTSNTHGTNVNVNRGCISVNDSPRCAGNAAYNVAYQQTYNSSATIYAQFDGSDSKDEYVRPGCELRAKFPSSYGDVYFGSDNCLYDSGSSKIFDQCCTAKATTTVRNPYYQTPVSTTTTSTTSTAQSAPTTNPNPAGTNLHINGGCVLVDDSPRCAGNEGTITKVYSGVYNIGSDPTKSTSSAVILAGFNKKDYTDKQQKAGCQLNAVWPSGYGDIYFGADGCLYDGGGSSIDSQCCSAAALSNQDPAHHFHERDCYAVKEVRDIPEELFEDVNLDDEESIGSWGEAMAAQLPGRDVDAVRIEVPDSLRALSTYAGPHYIHLRRKGISPQERELACYERERSIRNREVTLQTRTESFDGTRDTLLRGRNSDFVSGWDGLKHAFKKENIMMVNIGFLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULW0</accession>
    <name>A0A1Q5ULW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULW0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULW0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="25265" checksum="BB14A85F5FBD535A" modified="2017-04-12" version="1">MVKYVPELGLVVAASQKGRVAVISLTWQEEIGYAFRLDWVLPFHTQERSDERPMTPLLGMAVSPMPGYEIPPDVPCIPRGIDPDDWLQFNYRILNPEEDDTPSSPSKTSDSSASKPAAQQESSHDPQSDDEDDGEDYQSPSKSKSDSTHSDEASSTTHSNTTESSENNRNYTLPELHAHASRAYHPQERWQGWHPSRHYRLMLLYCDHTVMSYEFWHDWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM97</accession>
    <name>A0A1Q5UM97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM97"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF6">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="313" mass="34845" checksum="63DF203E42F00709" modified="2017-04-12" version="1">MGRIVVTGGSGKVGGTVIAVLLEAGHTILNLDLMPMTHPAVHTLKTDLTDSGQVFNALSGQWSLTEPFPEGLPPRPDAVIHLAGYARNMQVPDNETFRANTQGTYNIIDAACKLGVRKVIIASSITVYGISFAQGVVDYPSFPIDEDQDVNPTDAYAIAKLCNERIARGFATRYGTDIYSLRIGRVIGPDEYNQDIFYSYVHEPSQWKVHGWSYTDVRDLGGMCEAALRTNGLGFQVFNATNDTMTNLMHTEEFLREHYPQTPITRGMDKFEAPLSNAKIKRLLGFQEKHPWRKYFTLWDKKPVVRGENGDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMK7</accession>
    <name>A0A1Q5UMK7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMK7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="91" mass="9884" checksum="0F81600C17E9F793" modified="2017-04-12" version="1">MAESSTTGGDAPRTATLPATLLLLWYPISKQLLITPDQLIGQDYTGGKGRHTRTMVQHIHAWNSNPSRFGLASAASLSGRRPRMSPPDNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN00</accession>
    <name>A0A1Q5UN00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN00"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN00"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="93"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="267"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="668" mass="73989" checksum="8F6AE757F9D23C67" modified="2017-04-12" version="1">MQAPPEQFSLPVGTNMHASASVTQQRRPSGQSRRLSSIRSGNSGPAISTRHSVSSVNARNAARDGSQQQQEQLRRASLSASTQSSPPKWWRIRFFRGMMNDVKRRAPYYWSDWTDAWDYRIVPATVYMYFANILPALAFSLDMFEKTNQSFGVNEVLLASVLGAVVFSVFAAQPLVIVGVTGPITVFNYTVYDIITPRGTPYLAFMCWIGIWSLIMHWALAITNACNGLTYVTRFSCDIFGFYVAFIYLQKGIQVLTRQWGTVGETSAYLAIMVALLVLMVAWICGELGNSNLFKRWIRKFLEDYGTPLTIIFFTGFVHIGHMRDVDVSTLPTSKAFFPTLDRPWLVRFWDIDVGDIFLAIPFALLLTILFYFDHNVSSLIAQGTEFPLRKPAGFHWDIWLLGLTTFVAGILGIPFPNGLIPQAPFHTAALCVTRQVADEDDTNKGKAIRVTDHVVEQRVSNLAQGLLTLGTMTGPLLIVLHLIPQGVMAGLFFIMGVQALQGNGITQKLIFLAQDKDFTPGSNPLKRIERRAAIWAFVIVELIGFGATFAITQTIAAIGFPVIILLLIPVRSFLFPMWFTREELNILDAPTASPFTMESVGGTHGLEEETADSTATGADIPSGGGNGVLRGRSSSSESAVEEDDLERGEAYELQSTVHRRSSHSRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN50</accession>
    <name>A0A1Q5UN50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN50"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN50"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="703" mass="79625" checksum="7DC7AEC3923CD663" modified="2017-04-12" version="1">MAQSYHQSQAALAGFLDSMQQDTSMSAYNLFGPSQYPESVAFWHDPSAAPQPIALPAPSYPPKQPTLLQPLVDQKKHKRTRSGCFTCRSRRIKCDEGRPICERCRKGSRDCVYPSPNAPSAKGSRSAKSRSARPQSQGSDSSGKFEADEVSPLEPIIDEEEPEGTEVGSELSPTSGTGTGQSRHDLHRTQSGQSLRKRSLKQPSEAGSFNLEPSSSPSTESSRFESVSVRSASISQSTLDLLNNSRLSEDLRFYLDFHQQFISHEHFSLRQGSARFIHHSIIELALGYEPLLYALVGFAAYHHTLQSGGKLYTFLKYYNKALVLLRKSLESGEEHSEATLCTVLVLTTFEEYIGDWVNLIDHHQAAHALMRELLTPESSNLVELHTNIFLWYARFDVVAGILAGTETILGRDWYISKEQYDADQAAMYPEDPRKQLALVASINRRFGLDMASLYAKLSRGMIPFDQFALQNEQLGQSLEHAKNILKQFDDCEDTVRSYPNQQPLTDDDIVDPYIPGCILQGPLWDANYAKIDLLSTELMFKYQTMLSLKQPLIADLQRLAFEQCQLMETISRWPDKGNGYCIAFKNSIGLSSMFLPKDLKHQMWSRRKLALMEQNGYIIAPRFRAALAAIWQLPELQHWWLPNDEGYTDIIREVRGMSEERMNQPLDDFRENVRDMKSLFWKLSVDEGQNEEQSPSSSHNSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP91</accession>
    <name>A0A1Q5UP91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_37</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="156" mass="18024" checksum="1D93AD02C5FDE3FC" modified="2017-04-12" version="1">MATAEKTKEQQKQFQVPDYDSEEDYDSADDDIEYSEDEEEVQTVPNKNQQLQRRRRQQQQQSQGDLDEYSDEDDYDSEYDDDDDYSDDEVIQGKSMQPWSQGTTSGAPSGGMNVIPQEQKKSLDDEEGMKLKLELNLEIEIELKARIHGDLTLALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPJ7</accession>
    <name>A0A1Q5UPJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPJ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="113" mass="13241" checksum="122858B61CD01598" modified="2017-04-12" version="1">MPKAMDLAVWLYNRSIEMFCCSATDQLLLVQMPPDKTVGRKLNLIHFNVNRHDERHDFLTTWEVPRGSSPWKVSPLCMFQGLYLQQPCRKQPGKARVMQHDQDEPVFLDKQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPL2</accession>
    <name>A0A1Q5UPL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_14029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPL2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPL2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="376" mass="42273" checksum="669338DB29C81EEF" modified="2017-04-12" version="1">MSTQNRSLASNTLWPSYMPIHVALPIYKPILGFGTAMSDDPGVLFMGARSKQNQRHMSEESNEGGQSSWHHHFHPPRPEMAGSRPARLPPIRAPRDGFDYRRPAEVRAQEDDVIDLTNEPETPPQRTHTHNENRPPHSSSSRLPRFGRNIMAEADIVDLEDEPDDAGEGPSSSPEVQFLRATVRHPQPPPRRWEGVSLFQTNFPLTRSRAPEEVTPWARPRLPRPHNITVSHLDTLFLGARDSIPNMSSAEVYLDYTTSSFPMETAPTRYEDRRRRDTYKPPSPAPEGFSRTLGEDDVAVCPNCDWELGTGEGKKQEIWLAKQCGHVYCGECAENRSLSKARKAQTPPKTKPFSKCQVEGCGKLVSAPTAMLHLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ16</accession>
    <name>A0A1Q5UQ16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase proenzyme 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ16"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ16"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="43"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="441" mass="49125" checksum="9832ECAECF5F1890" modified="2017-04-12" version="1">MPSKKDAHHLHRVGGWMPADHAAHREWLGGVIKQVDHDDKALHPVLQEFKQLIESNTRVYMLLTGMFREVPHKRPYSKDPTGTVQIRDYDHFLRVLNHLLTSAPSWTDKAHRVGLVGLPINAVLDWAMGTPSGYAAFLDPEINAMLKKVLNVWGEFLKSPASAEVLNTTSHGWFGETGHRDLTLAARVGPTMAEDLKFQDMFQCDPSAPHFGFQSWDDFFTRQFSEGMRPVAEPDNGRVIANACESKPYRLAHNVRARDHFWIKSQPYSVLDMLDHDELASQFVGGTIYQAFLSALSYHRWHAPVSGKVVKAYVVDGTYYSEPLFEGVGNPQAHTADIDLEGQTISQSYITATATRALIFIEADEPAIGLIAFIGVGMAEVSTCDITVKEGDHLKKGDEIGMFHFGGSTHCLLFRKGVNVSGFPEPGREDNVPVRSYLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR57</accession>
    <name>A0A1Q5UR57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000043">
        <property type="protein sequence ID" value="OKP14952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR57"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="150"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="394" mass="42036" checksum="625CC1760326B058" modified="2017-04-12" version="1">MDAIAHSVDCISSSIARPTLSTVPYSRSTSRSGSRPGLSRRPAKFLGPLYHGLLILMLILCFSPISTLAQTIPGVSDPNEDGPRSALGPSGEINVGELAERRELFELHEIFQIDEADSDERATSPGIDRNGALLLPRSIVTAHNSSSSDLPAAFDTLSNNFANATCVAFFEKFRSNSSFTDCHAVSVLLGNSNSFFHTLTSAVATSHVLDVACSQSVTKCASTMTTLAKEMLQDKNCGQDYDANNSVVRSVYQELIAYEPMYRASCLTNPDTKDYCFVDAVTNTTAPNDYNVYFMPIGSTLTSSGKLTCNECLQATMKIFAQWASTDGQSLDTTYLPSAKVVNGYCGSGFANTNVTVGSSKVTAGAGQVMQSPSFRLITSLFAIALGATIAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URE5</accession>
    <name>A0A1Q5URE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_3441</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000030">
        <property type="protein sequence ID" value="OKP15046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URE5"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="40"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="316"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKP15046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="485" mass="54304" checksum="6F36DBC799BE77D1" modified="2017-04-12" version="1">MPSTSDLADPKEYQKILHWAETQKNGTIPSFATRRNDPYEYQAGFGNSFESEAVPGTIPRGQNSPRNVRFGLYAEQITATAFVAPRHANKKAWLYRARPAVAHQGFTELPDNKDTESNFLPLNPRIHVSPTQLAWHPFDIPENEEVDFVSGLKTVAGSGDPTLREGLATHVYVANTSMKKKAFVNSDGEFLIVPQQGALNIQTEFGPLFVQPGEIVVIQRGLRFRVELPDGPSRGYILEVWGTCFELPELGPLGANGLANARDFLHPVAQYEIAQEPWEVVYKLGGKFFKSTQNHSPFDVVAWHGNYIPYKYDLTKFVNVGSISVDHIDPSIFCVLTAKSRDLTSPLADLLTFSPRWDVASHTYRPPYYHRNVASELMGLIYGDYGGRSDAFKPGSVSFECGMVPHGVAYEEFKAASDEEPPVMKISEASIAIMFESSRPFTITDYAWNSDKKHEHEPKMWDSLVDNFSKHAKEVEEILAKKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNP7</accession>
    <name>A0A1Q5SNP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13713</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNP7"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="411" mass="45571" checksum="E94E40989CFEECBF" modified="2017-04-12" version="1">MAEAENGQAISADEIALYDRQIRLWGVQAQEKIRSANILLITAKALANEVAKNLVLAGIGSLTIIDHEPVTEADLDAQFFLEEAYKNEDIIKQGKNRAEVAGPQIHRMNPRVKLHIDTSNVRSKLPEFFAQFDVTIATELDFATNTTINAACRIANRPFYAAGLHGFYGYVFADLISHDFVIEREKSNGPTQQQETLTRSVVSVTTKKESEKGEKGNKGKVIELVTKREIYSPLQLANTSPLPEEYTRLPRRRKQVTPLLSCLRALWEFEKISSGRRPSFAHSDLEVFTKLARDSHQELKLDLDTLDSTFLRQFLQNLGCELSPVAAFLGGALAQDVINVLSAREHPLQNMLLFDGEQSIGPIYPLHPFFPPEMDVGSLAAVPPVANPIVLDPTMTTNLATHPAPNPAVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNQ4</accession>
    <name>A0A1Q5SNQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 11">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNQ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNQ4"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000026">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF14">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO89553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="432" mass="46544" checksum="FFD528E16A7C48EE" modified="2017-04-12" version="1">MVLKLKQPNRSNAGPASTVDVSAIVRGVINDIRADGDKAVRTYSKKFDKWSPESFKLSPEEIQQIVSTVPQQIIDDIKQVQENVRTFALAQRASLKDFELEIRPGVHLGQKNVPINSVGAYIPGGRYPLLASSHMTILTAKCAGVPHVTACTPPIAGKIPANTVAAMHFAGADAIYILGGVQAVAAMAIGTETMKKVDFIAGPGNAFVAEAKRQLFGEEIGIDLPAGPTEVLIVADEHANPFTVATDLLSQAEHGPDSPAVLITNSQSVGEKTIAEVDRLLKILPTADIAGVSWDRLGEVIVVDTLDEAYKLADEYASEHVQILTQKPREALEKMSNYGALFLGEKTCVSYGDKCIGTNHVLPTRGAARYTGGLWVGKYLKTVTYQEVTSEQESGELGRLCGRAARAENFEGHARSGDVRAHQFLGDKFEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPY2</accession>
    <name>A0A1Q5SPY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13558</name>
        <name evidence="6" type="ORF">PENSUB_4616</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000766">
        <property type="protein sequence ID" value="OKO89935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000420">
        <property type="protein sequence ID" value="OKP09976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPY2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPY2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO89935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37282" checksum="439ABCD558DCD410" modified="2017-04-12" version="1">MSALAKWLCGSAPVENKVLLMGDYECGKTTFLDRLKFEQVREHPNHTVNVNVETVEYPKGYNWHIWEIGGMVSLPFMIITRSLGKIKYADILAQKGDQKSRQLAWHHLSPATLVIYLHDCGNPADRVPVSFSPLLQDMANIGAKYIWIAFNKQADWGFKRARINTLRQEYEKELENYGGRISGKVLTHRLDAKSAEGTFIVLEDMFATMRDPRDNSPRLPAPGRPKKDLALQRLVEMEIAQDDMDPEVFWEYLQKGVFINWSHYHLIKALYMVVLQSVEEQAINPLPSVGSRETCFDIASTFDRYMNVMSRTSPRWFEKTRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQP7</accession>
    <name>A0A1Q5SQP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Urea active transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF1">
        <property type="entry name" value="ACTIVE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="57730" checksum="E02B5FA2B5797A2D" modified="2017-04-12" version="1">MLLGAAAVISAVSGMHIVAATFLLPVGVTVYTFVGGIKATFLTDYFHTAVILIIACYFSIKAFSDDQIGSVGNLFELLKAAAERHPVSGNQGGTYLTMTSKSAILFGILHTCGNFGLVVMDTSYFIKAFAASPAAVVPGYTIGGIAYFAIPWALGTVMSSVALGLENQPNFPTYPRRMTTSEVSGGLVLPYAAMTIAGKGGAAAVLLMTFMAVTSTLSAQVIAVSSILSFDVYREYFKKSATDRDLIRSSHFGVIFFAAFSAGFSTMLNYVGIDLGWTLYMLGVVTCPGIFPMVFTVLWRRQSKAAAILSPILGLATGLAVWLGTASHFGGEVSVASTGQVLPCMYGTVASCFSPIPYSILITLLRPQNYDWADFRKEKLALEELDSDLTTTHITESPNHSEESSIENGRVESAALESKELKRWGRIAAFWSIATFLGHWVIWPLPMYGSRYVFEKKFFIAWVVVAIVWLWGTMLVAIFYPLLDGGIQQIRRVYRGLTRKASIETNGTEKGKKVDGKIIPSSLSTGSTSEVPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQU7</accession>
    <name>A0A1Q5SQU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQU7"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="390" mass="42559" checksum="5508AC6CA84E00F8" modified="2017-04-12" version="1">MTQAGLSMSIAPVHIIGLSFGTSNPAELSWFDAAYSLTVGTFILVAGRLGDVYGHRRLFVLGFGCFSLWSLLAGFSVWSNKIFFDCCWALQGIGPAILLPNAIAIFGRTYPPGFRKEMIFVWRHCPWRIYSRWCVFIYLCPVCLVALGILGDGNGAATGISGFALINFAWNQAALVGWKNPYTYVLLIVGCIRLGVFAVIERRAVYPLLPRSIFTGDLAWVVGCIAAGWSSFGIIIYYFYQFMEVIKGDSPLLATAKWSVAAPSGAIAALVTGFLLGRWPPSVIMFCAMGFFYSWDMSFPSGTLILSNAMHRHHQGLAASLVATTVNYSISLGLGFAGTVELHVNDAGRNVLRGYRGALYMGIGLAGLGLNISICFMWASWRRYCASKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQX0</accession>
    <name>A0A1Q5SQX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylaniline monooxygenase [N-oxide-forming] 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQX0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000247">
        <property type="entry name" value="Flavin-binding monooxygenase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="525" mass="59728" checksum="CAB964116A0CD51A" modified="2017-04-12" version="1">MAASQSSILALIRHPFVQTFTWLYLILQAVLRYVFSPAPPPPTATKSNLPRKRVAVIGAGLTGVSSAAHCVGHGFDVQIFESRSKDRGLGGIWSFEQRVNSTSALQVHSLMYRFHPSVHYDSAYPTQQQIKEQIVELWKRYDLERRTVFDTRVTSVKKTKDGQWIINNDEENYGRFDGVLTAVGVCGDPQMPTLPDQDNFKGQIFHSSNLDGKDAKGKKILIVGGGASAIEALEFAVKSGAAEIDVLSRSDKWIIPRNVLVQSLLAFNIFGQETSLSWIPEGLLRKFFYRDLQDIAPTDDGIFTQTPMANSELFNQIREGKAHWFRGDIVSVEENGVRFNHRAQGVPKGGPGKEGLIEGDIIVMATGFKRPSLTFLPDEVFEEPYSPPDWYLQVFPPKYPDICANNSTYVNAIGTVGNMHIGIYTRFLIMFLTDPLTRPTEQRMKTWIDFTRLMKRFAPTRAFDFFTYAELIYWYIFVLLVNPFRWKWALFVFFGLGRALPLMVVEQEENFRRELQKQHKTDKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SR23</accession>
    <name>A0A1Q5SR23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_13468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SR23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SR23"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011833465" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="36"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO90335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="563" mass="61734" checksum="13D92B57EB9056E4" modified="2017-04-12" version="1">MKVVLSLLGLALACYASDLPVVDLGYELHQAISLNSTSGLYNFSNIRYAAPPLGDLRWRAPVLPKQNRTHVQTGDVGRICPQASTIWEDDIEPAFILSLLYNTTFTKSTNISSYTYEPAKVDPRTAEDCLFLDVVVPQKIFDRAKKHTDRGQHKSFVPKNKLAPVLVWIYGGGYVGGEKSSNDPTGLIERSQVVGDGVVYVALNYRLGAFGWLSGDAIIANGTANAALHDQRFALDWVYKNIHLFGGDPTRITVMGESAGGGSIMHQVTAYGGNAGPSPFKQAIIQSPGWVPIMDDEQPEQTLQQFLGILNVSTIEEARNLSSEKLIAANSYQIATKSEWGSFIYGPVVDGSFVPALPGKLLAEGNFDRNLNIMVGHNTDEGLVFTSPDSRNESGLTALLHQQFPYMKKNVSDYISNVLYPPKYDGSYGYTSSLTRAALAISDLIFVCNTDYFNRAFHNQTFAYEFSISPALHGQDVSYTFYNNGSSATGSILGVQNVTVAEVMQDYFTSFAQCGEPSSPLGPAFHRYGQRGSLMNIGNHTISPERDPTDNPRCRFWQTAPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRP0</accession>
    <name>A0A1Q5SRP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRP0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRP0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO90671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="97" mass="10187" checksum="5502BA80AADCF3CC" modified="2017-04-12" version="1">MVTGITIAMQPGQTTYGSSRGVGALGEFGADPGIEATELGAKGTFDLSTSASEASEPAEDFGFAYRLRKIHISWRNKIRLRGDVTGADLHGVGSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS79</accession>
    <name>A0A1Q5SS79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS79"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS79"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="540" mass="58295" checksum="4527A0F558059DF8" modified="2017-04-12" version="1">MSDALPDPSTHLQPPSKTIEKEDPGAEDHIASDSDEEHFSDASEGHSNLQTKSPQSGRASPVPRTRVQRVDDSAQHGEVPGTEAYEKRGQDAVPDEIEVVPEVSPSRDPSPAGSQDRPLAPGGSPIPRTVVEKVDPESPSHGEVPGTEAYEKRQADAVPDVVTKASDDLDSVLPPPVADRESPDSSASNSSNQSIPETRLSRVDTIPAEDELPSPPRAHQRSPSDAVPDTVENISDSPPPDHGEEHNFEGADDEDDFGDDFDEFVEEQGGMGDDDFGDFDDFDDGFQEPEVIEDAATAGSTIPQQPPVSISVPPLIDFDNFNSTSELLTALQGTLDSLLPAAQDLSSLPPVEPIPDASAIFSTERSLSLWSQLVAPPPLQPQNWVKSRIRRLFLVSLGVPVDLDEILPASKQKKLVLPSIDLDNSGTTTPFHNQSRKEDDDSATTGQAPTRSKTTRRGAAPAPELDLPSVRRLCATTDAALNGLTDSELTLHVSELEQVTLRASAVLEYWLKRRDGLVSEKEAFEGVIENLVSHVRRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUF3</accession>
    <name>A0A1Q5SUF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gibberellin 3-beta-dioxygenase 2-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13054</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUF3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO91647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="217" mass="23658" checksum="1545F3AB53E0A49D" modified="2017-04-12" version="1">MVAPRPLQEDGNILQANISALRDISLAILDSLSQSLGLTGMSHLTSTHRVGEASTTALGLLKYLSHGTSEDIGVGHIAHTDAGSLSFVFTDVPGLQVALPGTVEWAYIPPREGHAIVNVGDSLHLLSQGRLRSSLHRVEPYLDALNRTKYTIVYLVRPETDAVFIDGDGKEWKCKDWYLKKFEIFGKGAIDLSDSFVLTGRENYDGRWNPLTAAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXW5</accession>
    <name>A0A1Q5SXW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">PENSUB_12777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO92792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="468" mass="50467" checksum="3986AAD1D60F9F78" modified="2017-04-12" version="1">MSDRTPSTIFPAGPLSPSSPAAGSALKESRQLPVSSDHIPQTPTSPPLMSVSDQNNVSNFTSSQASPNQATIHHHPPHTSSPPSSTPMSTQASQQPTVSTTNSFPTPASSVSGHLAHMTSAEDTDHKALHGGTQETTRNMGDGSDYQTTEHRRTDHDRHPLKTASAVAGVHDFATGLSSDPDAMDLDNEPAPRGLPRNLGLDSLQKEFTSAFHLCKSSPIATGPDPSWDLISLYGLGSVAQSVARIHPVTGEKINRLRKSYEGKLKPLGLAGKNKPIKQDSSKEGSLRYLTLWPEEEWQNQKVFGKQIKTADMDSALLSLQNNAMQLQPGMAPNNDFWEDVLGLEKPAKAPGPSDAGKKAVPAPSGRLGTQAGMTGGAGAQDFGDRARPSRGRKRHYDDNSFVGYGEGYADDDDDTGFYSNGEGTGKKKRKKWDRKSLGSHPSVLLWVRQSKTLAYYIALDRFKRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZL8</accession>
    <name>A0A1Q5SZL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_12445</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZL8"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="235"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="800"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO93382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="916" mass="101455" checksum="893ED6EC5EF185A3" modified="2017-04-12" version="1">MSGRILSHRLVPLVRAGLARHLHNAGARTGGLLRADGGAALRRRAWPIGSNGIHNNVPAVRSISFARMLPKLALKLVRIPAMFGGATIAGVAYLQYQATQAGTYAVDMLKVFGETAGNTASGFFQGLQDVAEQTQRGWEKTAEDVDLPEWLQKILRLDEESKSQKEGPGGGGKEPKEGRAVGAAAATGAAFGYDQSNEEDSREDREIAEDDQMMLLTRKMIEIRNILQSVGQSGTLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPNAQAEYGEFPALGLGKMTDFSSIQRTLTDLNLAVPERDCVSDDPIQLTIYSPNVPDLSMIDLPGYIQVAGHDQPPELKQKIADLCDKYIQPPNIILAISAADVDLANSTALRSSRRVDPRGERTIGVITKMDLVTPERGHDVLTDEKYPLRLGYVGVVSRIPQTNALFSRGSGNITSAILKNENAYFSAHPSEFGPHSDTSVGVTTLRKKLMHVLEQTMASSLSGTRDAISQELEEATYEFKVQYNDRPLSAESYLAESLDSFKHSFKAFAEAFGRPQVREMLKAELDQRVMDILAQRYWNKPVEDLTPRQPELDPLTDLPKADPDSLYWHRKLDASSSSLTKLGIGRLATTVVASALQNHVDQLLASSTFASHPGAHKQITDACNSILNDRFFSTSDQVENCIKPYKFEIEVEDSEWAKGRENVSKVLKEELRACESATKHMEDQIGKRKLKDVMSFIDRVLKGDVVLEGNGSGGAGGFSSELLERGREGIFLRDRADLIKMRLLAVRSKQCATQKNKYYCPEVFLDVVADKLTSTAVLFLNVELLSEFYYNFPRELDARLGRHLSDAEIERFAREDPRVRRHLDIIRKKELLELALQKIEGIRQLDGRSMHRKADRAQAAKDTRSRWNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T080</accession>
    <name>A0A1Q5T080_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T080"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T080"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="52164" checksum="300D17FD22CFB602" modified="2017-04-12" version="1">MAAEASQPIETRLFINNEFRESSDKKTFEVVFPYTKEVVANVHQASVDDVNDAVAAGKAAFPAWRDLGVDGRAPYLRKLSELFLEANNELARLETLSTGRPISQFVDAYMSSEIFRYYADAAWNSQGTASTHTPGILSMTVKEPYGVVGLIIPWNFPLVMWSHKIAPAIAAGNTVVLKSSEKAPLTSILAAKLVQKAGFPPGVINIVAGYGNPTGTTLAEHMDIRCISFTGSSLTGQKIQVAAAKSNMKHCHMELGGKSPAVVFEDADLEAAATQTQFSIQFNSGQVCVANSRVYVQESVYDKFVAIFREKFAAVKLGDPLDPTTSHGPQIDALQYKRVQEYLGVGQKDASLTQGGDANDGFFVKPTIFEKVPEDSRLMREEVFGPVVAINTFKTEEEAVQKANDTEFGLYASVFTKDLDRAVRMSRALQAGLVGVNCTSPTNAKDAAFGGYKMSGNTREGLLYSMENFVQKKSILIKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0E5</accession>
    <name>A0A1Q5T0E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0E5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="32867" checksum="41DF9515034D1455" modified="2017-04-12" version="1">MQAIGPAPFDLWTADAGLGGIVSPALLLVCKQIYYEGKKYLERNQWRLDRWSTDPIVNIPHSVRDKVASLFLGRDTVGLFTPPGTVRDDKSVFGLVHRLPNIQHLTVGMMEDDKGLSGTPSPGDKVNYDDEDNLYGALSWLATYKPLFKRGSIKSISLECIKKYPSNLYPWVYIWSWVTTMTLHILDHGTPEKFEKMTDLLQEIDLLLGRFESGRVPTYRNYAPLLESSHESAARFRTLSDVLQEIWEGFGIRVSARDPGPFERGTMIVFERISAGGGADEVVGGEGELVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T120</accession>
    <name>A0A1Q5T120_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T120"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T120"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052391">
        <property type="entry name" value="E3_Ligase-Neurotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133">
        <property type="entry name" value="ANKYRIN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24133:SF40">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="677"/>
            <end position="696"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="349"/>
            <end position="381"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="381"/>
            <end position="413"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="838"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="904"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125836" checksum="44A99B37AD2A3B8C" modified="2017-04-12" version="1">MTKFIVTSTDFDPKLHELSNVADINLDPRYNPEVKTDIDRFIDEKVDELATHGQYNADLRRTVREHLVQGASGTFLWVAFVVPELMEMPTQQVERALTQFPKKLTNIYMRMLEIKVPENERAVVAGILHWVAIAVRPLTLTELATATHVSKSRLQHYITSTGGFLKLSKSEEAFLEQTVRFIHSSAKGSLVNLREGDAPFRELYLDPTQVHLRVATTCFEYIQSSPLKDEWINLRHNRSYLARPLPLRRYPLLDYAARYWPEHACLSSTEIVDMFRRWPNFCNRRSTIRDNWLKTYWSDSPLEWNTPRNFELVHLAAFCGIIPLLESEIVPQLLGLSLPYRKVNRTCDHNMTALHWASRNGRTAAVIRLLRKGASINGKGYGMTPLTWAIRNGHLETVNTLLANGASVDQRDYGMTSLNWAAWEGHKDICAALINKWAELDAPTTKGNSAWLVDAKSSSGEFPWRSAMEAANFSRQSEWVEEQWHARESAVPNLTMALLYAVLTLNMQVLRYVGSLIISRSQDWFWLNTRQGKIGGREICWAAVTPVGRARLLLDLFKDWRYVVSMLTRAWKEIPYHVVGSPCALLCFWLFANWHGLTTYVLNNLLASVVLVTLPIYVILFLVNHLEVLEFVPYIAAPIAASGMPSTHGSIWRVLFGLLGIGLGVCHWYGYGFAVNYYPYTYFAFLIGVELIRLVWVNVSDRSDGFTSLHLAASRGHDSVAKLLLRSGADIDAKDDAGRTALQIAIANGNISVERVVLEHELAKISPGRVPGSTALQLSAALGRLDLVRDLMTKGCDPNETDLEGHTALHSVAYFGRTAMIECLFEKPTPPIHGVNTLGETPLHLACLGGHLDIANWLLGHGANPFTLTEYGFSPLHYAIVRGDLGVSARLASIDNLVNHCGARRVTPLHLAIRYKRGDILDCLLRLSADPDKIDMFGRSAFDYASNATSLFNKMEEARGSYQVTAISARDDTLRNTVRILFEELREIPLDFDRLADLGYALFNLGKQDHARTAYKYIFAVAGSFFCACDGCLRFIDDGMYICHECWNVHLCDVCFNLYADGRTIVPGCQDHEYLHVPVDDVLRSPDLEQSQIRHAQLEWLEELQREVNNNERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T133</accession>
    <name>A0A1Q5T133_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_12233</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T133"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T133"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="891"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="928"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKO93954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1008" mass="108957" checksum="BD0723403F9FF34C" modified="2017-04-12" version="1">MENSFLYTPAEALEHFNVSEQTGLTQGAVLESRKKHGPNALAEEPPTPMWELILEQFKDQLVLILLGSAAVSFVLALFEEGDDWTAFVDPVVILTILILNAVVGVTQESSAEKAIAALQEYSANEAKVVRDGKVQRVKAEELVPGDVIHIAVGDRVPADCRLLSIHSNSFRVDQAILTGESESVSKDTKIVKDRQAVKQDQINMLFSGTTVVTGHANALVVLTGGATAIGDIHDSITSQISEPTPLKQKLNDFGDMLAKVITVICILVWLINIEHFNDPSFGGSWTKGAIYYLKIAVSLGVAAIPEGLAVVITTCLALGTRRMAQKNAVVRSLPSVETLGSCSVICSDKTGTLTTNQMSVEKIVYVNSLGSGLEEIDVEGTTFAPEGKLTRNGKVVENVAASSSTVAQLAEVSALCNAATLAFDAKTGAFSNIGEPTEAALRALVEKIGTTDAAVNKKLFSLPASERLHAVSAHYESKLPLQATYEFSRDRKSMSVLVGKGHEQKLLVKGAPESILERCSYVLQGPEGSRVSLTKSHAKLLSEEVVEYGNRGLRVMAIASVNEVSGNALLKKASTTEDYAKLEQNMTLIGLVGMLDPPRPEVADSIKKCHQAGIRVIVITGDNPNTAESICRQIGVFGPNEDLTGKSFTGREFDSLSEAEQVKAVQTASLFSRTEPTHKSKLVDLLQSMNHVVAMTGDGVNDAPALKKSDIGVAMGTGTDVAKLAADMVLADDNFATITVAVEEGRSIYSNTQQFIRYLISSNIGEVVSIFLTAALGMPEALVPVQLLWVNLVTDGLPATALSFNPADHDVMRRPPRRRDEPLVGGWLLFRYMVIGTYVGAATVFGYVWWFMYNSEGPQISYYHLSHFHQCSALFPEIGCEMFSNDMAKSASTVSLSILVVIEMFNAMNALSSSESLLTFFLHNNPMLIYAITLSMVLHFAILYIPFLQTLFAILPLNWNEWQAVLVISAPVIVIDEVLKFFERQLYNTKVIVAPAAQNGSAGKPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1I6</accession>
    <name>A0A1Q5T1I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000721">
        <property type="protein sequence ID" value="OKO94070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1I6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="120" mass="14332" checksum="7EBA8AE7FD8EE846" modified="2017-04-12" version="1">MSTQNLVAQTIVLFDKDIAHYFRHNSPDRKLVDSIQYDLRTVYKEPTISCCVYQHQHQHQHQHQHQHQHQHQHQHQHQHQQQQHINGSPWIFPVSNCRNYIAEYGSLAGFSFEQCLVIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2D2</accession>
    <name>A0A1Q5T2D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2D2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2D2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16716" checksum="AA344A70831E8C99" modified="2017-04-12" version="1">MAPMYELTYIGCGMKLPTEGFMDRASLFLKLQYAADILLWTTLWSVKFSLLFFFWKLFESVNSSMRLFWWVMCGVTASTWIISVVLQEFACDPIRDFFTLGALMEAIKIGRAKDQDATVQKTKPTQLQMIYQIPILSVIRDQNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2G1</accession>
    <name>A0A1Q5T2G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nephrocystin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2G1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2G1"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="243"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="671"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1002" mass="111907" checksum="28C038A4BFCFA1B1" modified="2017-04-12" version="1">MSGLEVIGGISAIITLLDASIKIYDRARNGMKLPETFESVQCRLPVILHILQTCKSGLESRKDSMPSDVCDALENIVDACTEKAQKLRDIFEMVIPGERDTWEKRYAKVIRRLGKGNKVEELMAALTQDVQLVVNNNAVNSATPEQNLELDNICNEMKSVKSSTPEREHTALAFHSGGGAQNNNVSSGYGQQINNNAHVGTQNFHSVTVKQKTDFSFRGPVGILHGQAPYIASELFVGRGYELDDIKKILHPDCKAQKQRRLVLGGMGGIGKTQLAIAYAETGRGSYKSVFWLNAVSEAALKDSFRSIASLIFDVEEPGVLEDKEVVRRVQQWLCAPRNTEWLLIFDNYDDPAQFQIDRYYPPASHGAIVITTRRPDLVAGTPLHVKPFRNIEDSLAVLKTRSKRDSAQSDPHAKLLAERLAGLPLALATTGTYLHRSTFTFERYLREYEKRWNISPHRPLQLQEYQERTLYTTWDLSYSRLEKEDPVAAKLLKLLAYFDNGRLWYELFQAGLNDSSPEWLREVIEDDVNFNGAMGALTEYFFVESHHTSGSWSMHNCVHDWTLAALNKNIDASLCWFVFDCISASIGDNRVDDFANLSYSALAAHATRLLQQRFCDNDVSYDIAPHRLDQASLIANLLRDQVLLVAAEKMYQRALAGKEKALGAHHTSTLQTVNDLGVLYRNQGRLRQAEQMYRRALAGREEALGVHHISTLDTVRNLGIVYRLQGRLDQAEQKLQQGLAGCEKALGADHILTLDTVNNLGIVYCVQGKLDQAEHMYQRALAGRKKAFGADHILTLHTVNNLGILYRVLGNLVQAEQILQCALAGKEKALGADHTSTLETVNNLGLLYHVQGNLDQAEQMLQRALAGRVKVLGTDHISTLRTANNLGILNCAQGRLDRAEQIYQQALAGREKVLGADHASTLNTVNNLGILYRVQGKLDRAELMLQRALDGRLLVLGADHTSTHDTINNLEILYRAQGRLDQVEQMNMRVKLGQETENSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2K4</accession>
    <name>A0A1Q5T2K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2K4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2K4"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="96"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="36607" checksum="E82306DD04F8D91E" modified="2017-04-12" version="1">MSLIQLQPHPFTSIPTHPSFSTDSSRPDLHQYISTALHEALDLLHSIPSTFTTDPKQHPSPPSQAKVKLLRGWRKPFESRASTKGREKEKDKSEFWVCRQSEHVNESSKGTASWREFEAGLRSEHAEHEMEYTPSVSAVERLLEWAPENIGEIEVDGVRFRGVNMEVNLITHTFHPSALISPRTFISLTISAAYDGLPSTTSQAPTLSQKEHRQGFLTVQLPLHPAISSTPKALHQEITASVPKRTIFANYASIERVELVQAGKATDQPSTEQSQSQSLIEWTMATTSDAGGSIPQWVQRSWALGGVPKAVVADVGLFIGWTMRRRQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2S4</accession>
    <name>A0A1Q5T2S4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2S4"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="934" mass="102133" checksum="089CE244BD72FEAB" modified="2017-04-12" version="1">MASIAPADDSNLLVPKAGTSASASAANTPRPIQSPQNPQESWSSESSANAIISDSPSNYSSFSSSDSDEHLPGTANEEVDEDDALDVVGVSIGREQSRMKARATPAEEKNRVLEQQGGYFTTIPIPDELSEDGLFVSELTAEPESVEPELAAAEQVQLATRSDRPAASVERHATPYRPHREYSAPLPVAVRDSKDSSASGSRTSFTRSLLKTSLPRRPRAWSGELKKFLPDLTSLTKRPSLPFRSANANNRARSQTVASGKQSQANSRACSLERRRREPSPTTNAPANDEELGDDAQPISELRTLDGSSAVKHSFSRRPSAAMPGRPPSLRRSSSDQSLYLRASSTASSLEQRPRYENVHSQVNSRFKAIKDSLQDSSSRLLSMPSLHLQDIRTDWTSRPFPSVTNITTERGINGSAHRTATPPPPPRYNTQSTHPIFEEAMSELTGDVVILGGYRGSILRSAKAPHRQLWVPMKVGLNLRKVDLEVGLTREDEERMEETIIPSGVLSHIGPVDVCRRLMKRLRKCDNAVRGDLRIWDYGYDWRLSPDLLSQRLITFLEGLPCNRPAPDGQPQNPRRGATVIAHSLGGLITRHAVNRRPDLFAGVVYAGVPQHCVNILGPLRNGDDVLLSSRVLTAQVNFTFRTSFALLPEDGHCFIDKRTQEEYRVDFFNADNWDKYHLSPCIKPVLPAVPLNTRFKDFALISKRFSMGPRDETTDLTPQAQAQDLSDTNDPTNENHNPHRTTPIHSHSLPNPSQVAATATDKATDTLVPSGVDNLVGPGATPRSSTAANQATSPTTIPRAAAMEYLHRTLAEVKRFKSELSFQPTHQAENRYPPAAVLYGKSVPTLYGARVSSREAIKHQDAYDDLAFAAGDGVCLASAAMLPAGYRVIRNGLVKCDRGHVGLLGDLEGVGQCLRAVMRGRKEGVGLGSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2W9</accession>
    <name>A0A1Q5T2W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Virulence protein SSD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_11855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T2W9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="770"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1237"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1288"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO94588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1388" mass="152700" checksum="5E3B72935666EF88" modified="2017-04-12" version="1">MDQQGQSGVPGPAGRKLHIAHRRSPSELTPLMSTIKLLSPCSLPKTAQLTRHLSFLVEQLAIQQQIELLQQQQQQIAATHQQYVNMGLLQPQQLGQVNAFSPGGSMGGVSPQVNAFQFPQQQQQLGVPMNAPNQHSHRRNQSALPGLPMGPPPAPSSGASGYADYNQQGQNNHQKNENTNHGRGRGGPPGGGHQRRHSLALPEAKKAAELAQQKRTASGFQFPAPAPGSENQSVSDDKPGSSTSPAPQGLGLQRAGNIRAGGHGRSQSMAIGGNRGSLSGRGAGGFQFPAPSEGQPDNQRRGSQAGGHARTGSRNFDGNWRQPNNQNQGQDQQKSFGGQQQQGGFQPGHRSRGSMNQSMGSIGQFQYPGQPQLIQLPQGQVMMANPQMFAGGQAQLTPLQLAQLQALQQQSGQGMGGLQASQHAPPQLSVQQQQQQQQQQRKTLFTPYLPQANLPALISNGQLVAGVLRVNKKNRSDAYVTTPDLDADIFICGSKDRNRALEGDFVAIELLDVDEVWNQKKEKEEKKKRKDITDARSGSNAGNDKLGRSDSNGDRQEIGPDGSIRRRGSLRQRPTQKKNDDVEVEGQSLLLVEEDEISDEQKPLYAGHVVAVVERIAGQMFSGTLGLLRPSSQATKEKQEAERQARDGAHGRHQDRHQEKPKIVWFKPTDKRVPLIAIPTEQAPRDFVEKHQDYANRIFVASIKRWPITSLHPFGTLVEQLGEMGDLRVETDALLRDNNFGSDEFSDAVIKSIGWEDWSVAKEGDALASRRDFREETTFTIDPEDSKALEDAFHVKKLADGMVEIGVHVADIAHFVKGNSLVDREAKKRGTAVYLVDRVMNMLPPRVSTELCSLVPGEDRLTVSVVFKANPETGAIDDDVWIGKGVIKSAGRLGYDEVNSVLTGKSTSTGAGITADNLQLLNDVANKFRDARFGNRAANVPSLRLLQQLDDENVPVEYNIFDSTPAHELVEELSRQANFYVARKLVTAMPEKAFLRRQPSPNPRRLTLFVERMNRLGYNIDSSSSGSLQSSVCKVEDVELRKGMETLLSKAMQRAKYFVGTGAADEQRQHYTFNVPVYTHFTNPSRRYADVIVHRQLEAVLSEGAIEFTDDAESLNKTADLCNNKKDSALNAQEQSVHIEACRKMDRKVHEIGGDLISEGIVLCVYESAFDVLIPEFGFEKRVHCDQLPLKKAEYRKDSRVLELYWEKGVPSSAYIPEDERPKPGNSRAAQAAAAAREAEAAKERARERDEAMRKQTETGTMSADDVDALFDDDEDVDEVTELAAGVSLNSADRSTQSMPPSPTRNGHHQQGPHRTRSDPKIASSTSDAPESKMTNKEKYLKLFKLREEDGEFIQDVTEMTRVPIILKTDLSKSPPCLTVRSVNPYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T3Z8</accession>
    <name>A0A1Q5T3Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T3Z8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1300" mass="142268" checksum="6F946817112679D0" modified="2017-04-12" version="1">MPPRLRSKPYGPNSPNAAEGLPEPAPRRRRATRSASAQPQEDQPAPPVREPKTRKTRGKAASRGRKKATSRTTHSPSPPPSATPQPNQLEGDDATSSAGAQAPSEKVKSPDVDLRTIPEHEDPHETTVGEPAVDQLQDDPLHLSLADLDLSERQKADQSAAEQIQAELEMHIPASPSVEIPVTVLPSIESSDPEVPTPIVGVCESPTPFFSLRSSRSALRSSSVSFFPVRSSSVDSAASTASDIPSSTTSTSTEIPGKQGRSWLMTQLRSLYRLCTRSQGASLPPVVTITAPAVGWSQDIPMLNPNTAQSHSALDDVKLISIIRAVRSGRQSTRRRSRASPSTSVSEQSRVLRAQEATPIHRSRTSYANRSNSRRIESRGSLGRTLYRLPQLLSFHSEPELKDGSGEETNPAHEQESPNLPPATVVLETNPPTTPERSTPATPVAPMTAPPAGTDVSPGWSRWIFNNVSRRWTDLRGRFAHDHDHETENENQPAVAAASEPAVSVAPTSPTELVLAVPVTIVDTPPTVVSRPFGSPTATFEPTKTPAFSPVGNDQEMSPRVRRGLPPSPPRRPVLPLPRPRRRTMSFVDTRTILAADDPSFDPDHETQHEFVKRRHAARAAVLRKRAEERNRETMAVKRAAAEEAARLKLYASSNPPKETSPRGSPITANTGNLRTSPISGLVPMASHFQTSPTSRGRASKEAPIQTAAKSNVDAERANPRKRSRGFGLDEDDLAVHEEDFTPEEWEVLKAQVEKAEEDAAKAAQESVPPTKKRRVDQSPKQQKRTQRSVRRQTTTPRHNQPPSRTTGFVPNRRGTFAPPDLSPIDSSRSLNDPDSPSVSQTSPAATQSLETNEVPRSTPKNGSKSRRESRAQASQKGTMINGVYFPKHPVPCCDSSAEEAYRFPHRAFLPKMAATYWLRRERRWNPGRLFTLPKLFQPQEAEEVPKPPQTPNAPKKRVRWADLESPYSSGINQDWYNERFESAPTTPVSILRRVREPSQTSRTFEDTSLAASSPTLPTMPRPAIKRKRDAASASDMSSSFLRPVKRSRGYQAPDPYGSSSSPSSASPQSPPSNAARYFSSLQPRRHLSQYVETSADITYPNAAATEDFAVENDDPSPLSRARNKAELFKPKTPSRLRESTRIPSSNTSTPSALGYSSPSFLGALLDNSPYRSDPMSIDGSSYLQNPDTPPVGSIPSGFRREDLTPLPPLRPGASPTAPIPANTPPRTLVDDVAWLLQASPDGNFAALPWPARGSLVEVLDTDSEAVPIVEKYWQVEGADPVEYFEAQFEKFESLGLRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5K3</accession>
    <name>A0A1Q5T5K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_11029</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5K3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5K3"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11734">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssc1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO95517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="665" mass="71973" checksum="6FEC571D6A736DCA" modified="2017-04-12" version="1">MLSSRISRALPRAAFARTPASRLPAVRRWNSTEAEGGKVKGQVIGIDLGTTNSAVAIMEGKSPKIIENVEGARTTPSVVGFAQDGERLVGIAAKRQAVVNPENTLFATKRLIGRKFTDAEVQRDIKEVPYKIVQHTNGDAWVEARGQKYSPSQIGGFVLNKMKETAEAYLGKPIKNAVVTVPAYFNDSQRQATKDAGQIAGLNVLRVVNEPTAAALAYGLEKEADRVVAVYDLGGGTFDISVLEIQKGVFEVKSTNGDTHLGGEDFDITLVRNIVEQFKKESGVDLSGDRMAIQRIREAAEKAKIELSSSLQTEISLPFISAGSSGALHINQKMTRAQLEALVGPLIDRTTEPVRKALKDANLKSSDIQDIILVGGMTRMPKVTESVKSMFGREPSKSVNPDEAVAIGAAVQGAVLAGEVTDVLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQTFSTAADMQTAVEIKVYQGERELVKDNKMLGNFQLVGIPPAHRGVPQIEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSDAEIQNMVDEAEKYGEADKERKAAIEAANRADSVLNDTEKALKDFEDRLDKAEAETIREKIATLREFVAKNQSGEGTATAEELKAKVDELQTASLTLFDKMHKAQNEQQQQQQGGEQQGENKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5W3</accession>
    <name>A0A1Q5T5W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_11139</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5W3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5W3"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="228"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKO95627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="456" mass="51705" checksum="18B0CA523EABD3A3" modified="2017-04-12" version="1">MWILEQLARLLDRPLFPWKNVLVGFSLGQFVLEGLLSLRQYKVLQKTKAPKVLEGEVTQKVFDQSQAYGRAKAKFGIVSGLYGQIQNLVFVYGDILPKLWGVAGFVLARYFPDRFQGEISQTLLFIFGFNILSTILSLPISYYNTFVLEEKFGFNKQTLKLWVTDMLKGQMLGIVLGTPIISAVLKIVQKTGNSFFYYLWLFGVFVQVFAITIYPIAILPLFNKLSPLQPGELKTGVENLAKKLKFPLSELHVIDGSKRSAHSNAYFYGLPWKKHIVIYDTLLEKSESQEVVAVLSHELGHWSLSHTTKLFGIAQFHMFYIFALFSVFVNNKSLYQSFGFVKEQPIMIGFLLFSDALAPMDAVVKLLMNILSRKFEFEADAFAQGLGFSDELASSLLKLQIQNLSTMDADWMYASYHYSHPILTERLAALGWKGGKVTDLKEEDSEKPAKAADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5X6</accession>
    <name>A0A1Q5T5X6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">PENSUB_11132</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5X6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5X6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="223"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="427"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="591"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OKO95620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="684" mass="72056" checksum="7A7D97497A0C7BE4" modified="2017-04-12" version="1">MADGLQMGNLSLQDSQHAPQGGPPGRAAYIPPHLRGRPGGASMDGPAAAAPPPGPAGGFSGARDARGGNWANANAPNFSPRGGPANGNTSWNPNGKLRPFDPYAYGHPGQGGSYSGGGGSYSGGGGASARGSGDGQWRDGKHIAGPANPRLERELFGLGQDDPSKQHTGINFSNYDDIPVEASGQDVPEPVNTFTNPPLDDHLITNIKLASYVTPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILSQAFQTGPSAAPQQAGGGQFYGRQRKAYPTSLILAPTRELVSQIFDEARKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLVNIKYLVLDEADRMLDMGFEPQIRRIVEGEDMPSVEDRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKIEYVEDVDKRSVLLDILHTHGTTGLTLIFVETKRMADSLSDFLINQRFPATAIHGDRTQRERERALEMFRNARCPILVATAVAARGLDIPNVTHVINYDLPTDIDDYVHRIGRTGRAGNTGIATAFFNRGNRGVVRDMIDLLKEAHQEVPSFLESIAREGSGFGGRGGRGGRGRGSSNATRDVRRFGGGGMGGGQSSLGGSGYGGAPSYGGSGGYGGGAAPSYGGSGGGAGGYSGGGGSYGNPGGATGPSSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Z3</accession>
    <name>A0A1Q5T5Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Z3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Z3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="623" mass="67933" checksum="901E2CAF790B44CB" modified="2017-04-12" version="1">MSSFFTVPASQRKRKRDDRAAAPATKKRGVDAKNDAAGGRRARERDDSISGSDLDDDEGALGSVGSGEESESDSDDGETAADRRLKLAERYLDNIREDVEDTVGFDAAEIDRDLIAERLKEDVDEFKGRAFRQIASHLSFSEPSHSFFRSDTQSTTSIAVHPPYAYTVSKDKTLIKWELATPSAPTTSETKGSSTRPPRPQRRKPKRVKYARGVRKIAETGEESGHTGSILSVAVSPSGKFVATGGADNRLVIWDAETLTPMKTFSQHRDSVSSLAFARHISTMSSGEQLFSGSYDRTLKTWSISGAGHAYVETLFGHQDHVTSVAAMTIDQCVSVGARDRTARLWKVVEESQLVFRGGASKKAPYIESNIDCIAPLPPNHFVTGSDSGSISLWSMHKKKPLHTIPLAHGLDPIPPLDELSPEVDPETSARNARHMRRMPRWITALATLPGTDVVLSGSWDGWIRAWRISDDKRTIIPLGPVGAGSLGRAAPDTPSKQLNTALALDTTPDPDDMEVEKKLENETQEPQPLIKGVINGIAVFERRPENAHTSSSTKPSSKSQKDSAPEARGLCIVAAVSKEHRLARWKCYANNYDQGSTSDGRNGAVVFEVPFTSTDAIVETDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T627</accession>
    <name>A0A1Q5T627_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T627"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T627"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="6">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="527" mass="59648" checksum="C693EA20C94E3537" modified="2017-04-12" version="1">MSSSRGFNDHNGGSSKPPSLSSSSTGPAKKAAFAFQSRGRPSDPLANKSRSLARRPHHLDHDDDSSDEERAPEHEEIAGFDTLTGGQITADGQAVSNAKQPLVIPVTSKNNWRDRPGTNVKKSKKNLLPQEVQAMQEAQKNGQAPPGGAVETEGPSMAYGLSFAQKPSEQDGKDSTAKEDQPMPDAQPISTENQKPLTEDQIALQALLRETTGEVERRTDLVIESFKPGEDEEPFRRHDETSSFRSDVASRPEPATLDQYNAIPVEEFGAALLRGMGWKDGQSIGRGDYSSATAAKKAKNPGVPERRPGFLGIGAKDSGKGAEVELGAWGKSAMRKASRKQGEENADGNVEGVYMPVTMRNKKTGEYITEEELADLKESSKSQVDKDDWRERRDRNLEKSGREGDRDREYRKRDYDDDRSDRRNGSSRRDRSSSAGRHSSRRSKYNDDDDRRRDDRSHRDRDRERDRDRERRRDREDDKDSRKDRDRERDRDRKYRDDRYSSSRHSSHSSRNDRDRDRDSRRSRRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6D8</accession>
    <name>A0A1Q5T6D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6D8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6D8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057026">
        <property type="entry name" value="Znf-C2H2_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24537">
        <property type="entry name" value="zf-C2H2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="697" mass="76293" checksum="8C5E7D7E951353C2" modified="2017-04-12" version="1">MDQRMSSHSFYDYKDHHDRHSDRVHMMPNSSFSSHGPLPIPSRPVMHTAPPPLPPPPRIRDLENGYDAGWLYANSSRSTTSLPPINPNSSLFGGHRRPDSAPMSDRMAVDELEGRQNGFPLSRSPEAQIKIEPPPPTDEGFPNSMAVNTTGPILKGEQNFSLRSVKDSSNAYDQHVLSKIGNTLSPRNSISQGSDHRGSISALTVPSIPSRASSNLPSPGPSEAGSTLDVKWYSSPQSGGVSPRSKVGWREYIEGRSPSVESNAPSSALDYDYMRDVGRRRYRGTTPSREDSISLPSRSNRGSYDQGVFSDIDGEFSTDELAPPRQFILREPTPPYPEGSRQGMKRRASSPPREPMGDDRHTLHSATSNGDLSQRRTSGQPFTNTLSVNPSYAPSHRTLSAASSLSIRTSGSYSSALSIGGSSMTSLSPYDRPSPGGLSPSSDLDAFHEKSILNPSSPVSLMQSLPRSVTGSNTLEPPATDATGKVSMPSILSVPKASPASKMGGLYICDCCPKKPKKFDNPDDLRSHEMEKQYSCQYCNNRFKNKNEAERHQNSLHLRRHSWSCAALPSFQAAFHGSTAPSCQTNAGPSHDSCGYCGEEFPNFPRPDWDRRFEHLTTVHKFGECNNAKKFFRADHFRQHLKHSHAGSSGKWTNILENACMKEEQPPEPRDKSGSISGPQGSGSLTSNTIEEVLSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6Y0</accession>
    <name>A0A1Q5T6Y0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ilp is an apoptosis inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6Y0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T6Y0"/>
    <dbReference type="OrthoDB" id="5335812at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053267">
        <property type="entry name" value="Verrucosidin_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42087:SF1">
        <property type="entry name" value="ILP IS AN APOPTOSIS INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO95989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24417" checksum="803DA1433048C42D" modified="2017-04-12" version="1">MNSQSQFDPAAMIGLVGVSPGRTEDNFDIFEWYPRYQSCQRYFLDHAQHSVPVQALSAFLNIKLPFQRQPNPIMNSIPVSAPSPAGAAPPGPTPSGPPAVSLIPYIRRLVATGMDFPGVLHGFFGDDWGTGVGPLHEQERRNYLFAAKSGGWASVKKDYDIPPLETIPFLRPLQGSLDAEIEAAERSWSEWLAMEDWMVGPRAPDILHDSSSQNSRPRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8E5</accession>
    <name>A0A1Q5T8E5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8E5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8E5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="8">
        <location>
            <begin position="219"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO96502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="387" mass="44099" checksum="0CFCE963AB9F952D" modified="2017-04-12" version="1">MFADLVGEGWDDPQELRKEYHPFGEKAQRLIDGVFLVTASREDDLAQKVNGIKEHFLKEPGSGDADTYRVSNDPVLEFPLIRQGQTRPDKGKEHFGFEDGISQPLLEGLDEVSIKEKDPKPTKSGLIFAKHDGDDMGQPDWAEDGSFMVFRDLQQLVPEFEKWLEDNKHKAPFAETSDNPKEKLAAYLMGRWRNGTPVDENPHDDKDPSLFRSNNFDFQPVDKHDKCPFAAHIRKMRPRGDLDHDHAVIIRRGIPYGGEVTPEEKAVQRSDEENERGLLFVCYQSDIRNGFNFLTTRWASNHYFPDRKSHFIDDHGPGIDAIVGQKLDHHPPRSIGLPDGKNPTEARVDLERWVIHRGGEYFFSPSINALKGYLTDAPDYPPAFTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAV5</accession>
    <name>A0A1Q5TAV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_10122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAV5"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO97328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="509" mass="54953" checksum="FC8E960D1239DE00" modified="2017-04-12" version="1">MTPSPSSLSPIPPPIPVDTHPNRAPGSRPPEQDRIPDPDRLAPEDAYFAPSLSRVRSAPANYEESLRSLNGDASGVATLRPPRGTLGVDLTRKDGRKLGAAGPRRRRKGAWKKLLWVKQSYPDNYTDTETFLDHLQRNPRVRPYDFWPLVSDSTVIVQHVCSVVIFVCCFVGIVQDRVSPVSIVCWGSVGTAMGWILWDNWIWREQAELAQSLNAASGGDDESSSSSMTSAPNPSGNDQGPNGTKGSPIHGLGLTMSTNESKEQISQLTAEIHGSLEGIGDPALRLGPSSATPSIALGSTDAQDTERASLFSSRNRQRLSTVKSAFLIYFSLLGLSPILKSLTKSTASDSIWALSCWLLIMNIFSFDYGSGEGAGATTKFPASLSTNAAVMASTVLASRLPSTTHVFSLMLFSMEVFGLFPIFRRQLRQISWTGHVILTLALVIIAGGAVGTTLGGGWASAVIGSFLGSVLTAFSMGGCSWWLISLQKYKNVVIGPWDPARPIIRRHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAY9</accession>
    <name>A0A1Q5TAY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase-associated protein RTF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAY9"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="611" mass="68365" checksum="AB93BED9C52ECB1D" modified="2017-04-12" version="1">MADDLDAELLALAGDSEEEEHSPPPRKDDSPSPSPSPRSPDHDQSPETMGRKGTAKPSRRGKRPVRDEEDGEVSEAESHDSLQSAPMSESDSEAGDASDDEDRPIFPYDKLYYSAKEKQEIMAMPEIQREELLSERAQQVDRHNQDLALRRLLASREREEARAAAKQAKRKAGSAGLDDTQRKSSRQKTTLGGRKVGETSGAIEAYKRQREQKGKRDELRRRDPTQSRRRSRSRGSDLSDEDGELESDLELEDRRSPSIPKDDPPAELRDIQRARVGRSNFAQVCFYPGFEEAITGCYARVNIGPNHDTGLNEYRLCLIQGFNTGKPYAMEAKNGRPFITDQYAKLAHGKAVRDFPFIACSDSPFSDAEYNRYRKTLAVEDCKMATQSNLASKVADINRLINHVFTPEEMSRKLRRQGVLDEDTNILRRADLERDIKLARANGNEEKADALQKELDEIVNPKLSWGTSLIKQQTGSDKKLSEAERVHQINLRNQKLNYENVRRAQLEERKAARKSAAAVARGEAAPDPFMRVRTVAKTHHDLSDKPKDGATDDTPTETPKESPKVGTDGVARAAAASGVTPKKPKSGFMISYRNTDDENIAALDLDIDIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC67</accession>
    <name>A0A1Q5TC67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="514" mass="57987" checksum="AC0960A74C18CA95" modified="2017-04-12" version="1">MAPQVRVFPRTSNATPLPYTASPLRLFWSDLCLVLRDAWALPAIFFPLRLGRTSSLDELYLSFQGALSLVTQAFLTVYQLLFLLSLPLMIICFVPALWILVYVAAALALNYVICMFVLNGFRRVLVSKVPVVEQPGHEKERWLYINGIANGHYWVQANIDQLSYTFGRKITGIHNRTSGVLFDLAECLIQRCFAYATGDVRSAYVLIKEALLDPSVEKVVLVLHSQGGIEGGLIIDWLLDELPQDLLHQLEVYTFGNAANHFNNPICSCRSSVEIESSNRDPSKRRSVGYIEHYANREDPVSSLGVLRFVNIPNRYLGRLFIRPGSGHLMNQHYLDTIFTLGSDRKVLESNPFMDMTVEVKPDLKIQSRGAASGVQGSFCEPSEDTLTPMVKSERRVAIDETDHQILRVKDFSRLWQYRNGGSPERQKTTQISSQQAKANLHHNYQAEYTNPRNLATILCPFLANNINHGFLWSMLWQLPKLKLAPLSNSSFFASAQPISLGSAKPKVILLHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC74</accession>
    <name>A0A1Q5TC74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC74"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC74"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="445" mass="50777" checksum="DCF12831314906FE" modified="2017-04-12" version="1">MWWLFGNNESKKAKAHRSSRAGHFFSTRETYPQRSHNTACGGSSLEYQIQEMTQGLPRDLKKKKTGSHGGESSSLCDLHWSLNYYLVDDILRLVKREVTSHFRQLDAYPDLIEPVEADILHRLRALKGLWTKPNPDGPVAPNAWPYQINGCAACILARIASDKDALRNLRVVIQSRTRTRKNHRPRELNIFVDHCIDRFDPVDAEELHTIASQLAFGMKRARKACVKAYMHDREDDPEREMRRKHRHHSRRQDHAKRRRAPSIPFTTASAENLVITPSLIAYPLDIHHIQDIDSSDMCDNPRRRRSDAPSPESPCFKRTNRGSQVIFSEVEWGNLAKQRENATMYRNIAGDNPYSRATPVLEVMVDPLGAQKARRYSESSLALFRPPVCALDGDSAKIKNGIASGSVSEWTDDECEDLDCNFSTRRGAISRDTTWSLVCEPHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD91</accession>
    <name>A0A1Q5TD91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Delta(1)-pyrroline-2-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF23">
        <property type="entry name" value="PRNX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37985" checksum="A0E1EA1C04E82965" modified="2017-04-12" version="1">MHILSEPDVAQIFRSLTQSQCHEFISSLGDALIAISAESKPDFPTSEKLIHQPLRTVFATKADNSCIFMPVSDTVTTGVKVVTVAKNGIQGVINIFSPDGRLQGLLAAAEVTAFRTALASMTLFVRSTAIRKENILVFGSGRQAEWHARLALLLCPNQIKRVTFVNRGRQRLEEMEQSVFNDLRQRYPNVSVNTLAKEGTPDYEQRLLAELQACDVIFSCTPSLTPNFSYSALQSAPKQRFISLIGSYKPPMHEIDTETLLSGGGKIYVDSKSACLEESGELITAKITEDELTEMGDLLGGLGPSDAIEIPEGANVIYKCVGMGLMDLVIGKKVLEVGSASGLGTHVDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDA9</accession>
    <name>A0A1Q5TDA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDA9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDA9"/>
    <dbReference type="OrthoDB" id="4366702at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="478" mass="52281" checksum="B034D59223256C75" modified="2017-04-12" version="1">MALVPPVQKDGFSYAGDSFYREASNLNRHRRATLPELKNHFNGKDTENRPAHWYEAQLLHYGLPPSKVKGTAHKRLFDAVMGSGLAVPSHIQKIETDLKKEWAKKEREAKKMLKESATTKPPAKGTKRKADQVSTSTSVNVSVSVSSTGVVEVQAAAKKAKVTPKTTAKEKKAAPAAKPIAPTAAPKEKKKQTARKSTAPSTTVEVAKTTTVKPKAAAAAPKEKKTTAPKTTAEEKKPAPAKSTTAAAKPAKPTANPKPKGAASKASQQLAPSQGHDHADAPPPYSEYDPGVGSGWMESVPPISPTSPRRRIGLLNGRYSVSCDHVELNFPEYQDRLNLIATLDGNALWLNFNLGVATGMMRVQRPYEVNTEDAITVFWRGNALPRMTNQRELFNIDTDGRAGSSNGLFFMGDGHLRGFIRYGSERDDNEVDLEFDAYRQPNQSMTSEISPTEAREIWASLQERQGSYYSDSDSYDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDU9</accession>
    <name>A0A1Q5TDU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_9492</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDU9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDU9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="5">
        <location>
            <begin position="14"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO98394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="620" mass="67240" checksum="28F6A66C84F4BFCB" modified="2017-04-12" version="1">MGSTTVHGIGEYGSHPIAIVGMSMRLPGGVRSAADFWQLLSEGRDGNCVVPRSRYNEEGFYSETGAHSVRMRRGYYLEENLETLDTSFFDMEGLQPSRMDPQQKMLLQVVWDCLENAGQVDWHGKPIGCFVGTYGGDWEEIEVRDSQNAHNFHMIGHGKFSLANVVSYEFHFNGPSMTIETGCSSSMVALNQACKALLMGDCSAAIVAGSNLIFTPTVGMHGSGLSVFSPSGISKCFDASADGYGRGEAVNAVLIKHLDDALRDGDQIRAVIRSSMVNCDGRSPGITTPSAEAQERLIRETYKRALISDLSQTAFIECHGTGTLAGDPIECSAIAKTFLKEIYIGSVILDSFSSLMPNSVLEDEVKETTPRLLVVSAKSQEALLSREQSLLKYRSLHPSRLSDLAYTLGVRREHLSHRGFLVNKNGIAPEMGAIKHSIAGRAPDLTYVFTGQGAQWAGMGRGLMKTFRSFRDSIQSLDIVLQTLKRPPSWSLEVNLLSEWGIKPAAVIGHSSGEIAASYAAGAITAESAIALSYYRGLLVDEVGSEGAMAAVSLGRVQVASYLRDGVVIACENSPNSVTLSGEPRQVEEVINKIKPDFPDALCRMLRVNRSYHSGTDPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE97</accession>
    <name>A0A1Q5TE97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE97"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="354" mass="38285" checksum="23AB914EB1B78DDE" modified="2017-04-12" version="1">MADLTSSLSMLTDNPAMAILNDVYTSFSERRALLNLPNPGTVDNIAREVQKEVLLSNFMFSGLRADLTKVFGMSPLFRVSHAFSMGSSGNLPPYAFSSMYGSPKVFMQGNLGSDGTLSAVYNWRWTPALVTKTNAQIMPGATQGLMQIDNDYTGKDFSASLKAFNPSFLEGGLTGIFVGSYLQSVTPGLALGFEAIWQRQGLNTRPETALSYCAKYKGDDWIGTAQLQAQGTFAATYWRKLSERVEAGVDMNLQFAPNAAAMMMGGPSREGTTAIGAKYDFRASSFRAQVDSAGKVSCLLEKRIAMPISLTFAGEIDQAKQTAKIGLAVSLEIAGEELMEQQEKADPNMVPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEV2</accession>
    <name>A0A1Q5TEV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Cysteine dioxygenase</fullName>
            <ecNumber evidence="2 9">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="2 9"/>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEV2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEV2"/>
    <dbReference type="OrthoDB" id="543511at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019448">
        <property type="term" value="P:L-cysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918:SF1">
        <property type="entry name" value="CYSTEINE DIOXYGENASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0883">Thioether bond</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="cross-link" description="3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" evidence="7">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610300-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO98722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="222" mass="24865" checksum="B3F344DD5BD47F50" modified="2017-04-12" version="1">MLPLMLPVSTTSATIDKGSATPYLRFKERYNLGELVQDIKQHLGHSGGISSEDVDSDYLRSLLEKYISDPSDWIQYFNNDRSKNYTRNAIENINRKANILLLVWNPGKGSPIHDHANAHCIMKVLAGELHETVYKSPENKTGKSKPLEIKSSNTFGLNEVTYISDDIGLHRVHNPSSEQIAVSLHLYTPPNAADYGYHIFDEATGSASHVPQARSYLKPQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF06</accession>
    <name>A0A1Q5TF06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isomerase YraM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF06"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="43449" checksum="2CA1B7D660127969" modified="2017-04-12" version="1">MTITNLEQVPAPILFQKRKRIPAVWMRAGTSKGLFFHERDLPASSKLWDSILLSAMGSAQANSRQVNGVGGATSTTSKVAIVTKSKRPNIDVDYTFVQVAPDQPRVDMTGNCGNIASGVGPFSLDEGIVQARPGQSEVDIRIFNTNTEQVIVETVQVAPDGTSREDGEYELAGVKGTASPIKLAFVRPQGSMTGSMFPSGMKQQSLSVDSQTHGSFSVRASLVDAANPFVLVDASSLPFSSDSLHLKANDSDFISVAEEIRRAGAVQFGLATDTTAAGLIRGTPKVAFLSEITSELDQADIDVLSFSMGRAHPSLQLTGAVCIAAAMATPGTVAWELAGGKKLEMVPKHGMSVANQEIASPLPVGIRHPSGIIHTETTLEMDHIGEVRVEKVAVIRTARRLFEGNVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF42</accession>
    <name>A0A1Q5TF42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF42"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF42"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160964">
        <property type="entry name" value="MalF N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="159" mass="17714" checksum="4449A4B8D672E8BF" modified="2017-04-12" version="1">MKAVRVRRETRRLHHWPEIQLNIWLIVVLSASATCLGIFSWFMIVQSQMDLGTPWLFPFMVVVSAIGVTFFFLIQVLIAQGKLLPGILIVGSFILFVLWLTGLIETALQLYGVSGNVNDNCQIWVVENESRGNSINTLAWLTQSTILNLGGNGLAAELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG43</accession>
    <name>A0A1Q5TG43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG43"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22573" checksum="B03F4065369036F9" modified="2017-04-12" version="1">MADHHSARKNAQILLKHRVPKDLRLKLKHARAARGMLQDLEDDIRLFIRQWNDKQVFLASEGLADAPEIEAEDSEDEIVFVGRNGQMHDAPERVQKLQQMRAQMNLHHERDGEKMVFESLVEDRAAGFGRWLVHSIASYYGLHTWSVTVGEPARREAYVGFRPPVPGSRAGLVTHPTCRAEELIKPGEELPQPLYAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGC1</accession>
    <name>A0A1Q5TGC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC-type Fe3+ transport system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGC1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGC1"/>
    <dbReference type="OrthoDB" id="124329at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006:SF2">
        <property type="entry name" value="ABC TRANSPORTER SUBSTRATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30006">
        <property type="entry name" value="THIAMINE-BINDING PERIPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13343">
        <property type="entry name" value="SBP_bac_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012772966" description="ABC-type Fe3+ transport system" evidence="2">
        <location>
            <begin position="18"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39404" checksum="1BDC3AAB4577AAF0" modified="2017-04-12" version="1">MTMRVLKALAFMPSVLAAALSPVPIDSRSLSDIYAAAQKENGVLRVVHGGDERDQADALFEAFSAKFPNVKVNHTVDLSKYLDGRINQAFLQNELYADMAILQTLHDYDAWEEKGVLLHYKPPSFDNVWPSLTNANGAYIPVFAASFGPFVFNSSAIPTADIPKSYGDILDPKWKGKIVLTYPNDDDAVLYLFKLIIQQYGWQWLDQLLEQDVQWVRGTATPAEIMLRNSSRTISFTTYPPAEGWTSVSPVSDRYMSWTQTSAIFKDTKLPETAKLLQAFLISEEFQVSRGEPSVRKDVGNSTIWDADNTDYVTFHQFMEDRDAVEQLRFVFEDKIGTAQGLSPLVDDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI70</accession>
    <name>A0A1Q5TI70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_8138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI70"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI70"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="119"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO99921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="561" mass="61288" checksum="68139D202DC5C913" modified="2017-04-12" version="1">MDSANRDSSEKTLAESVASDKSNKLDNSNNSHDKSEDDKPTDDKPKEGTDEPSIIRERSSNEVTKDATLDTKDVEANIQRTITTKLFPVTNLDEGIVGWESQDDPENPQNFSMAQKWGLLALMSAITFISPLASSTFSPAVSYVAADLHVTNETVLSFSVSIFLLGYAVGPLILAPMSEIYGRRIVLSCANWFLVLWQIGCALAPNIETLIVCRMFAGMGGAGCVTLGAGLIADLFPIEQRGLATALWSSGPLFGPIVGPIAGGFMGETVGWRWIFWMVMIAAGVMAFGIEILNRETCAAVLIRRKTERLSKELGRSDLRSAYATNAEQVSLSSTLKQGLKRPIILLVRSPIVLLLSLYMAVVYGLLYLFFTTIATVFMTQYGFSAGLSGLAFLGIGLGFLIGLIMYGLTNDRVVLKLIQRNGGKYEPEMRLPAMIFFACFLPVSFFWYGWSVDKNAHWIVPIIGMLPYGIGMMGVYLPVQTYVIDSYQRYAASANASLTTVRSLVGAVLPLAGPQLFRALGLGWGNSLLGFIALAFLPVPIFFSRYGQRIREKFPVNLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIC6</accession>
    <name>A0A1Q5TIC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIC6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIC6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7907" evidence="1">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="153" mass="16815" checksum="338AAD2F182373C9" modified="2017-04-12" version="1">MANPVTRTTKDFHLKTSGAGDSRHNNLFVYAYHTGAGFNDAVLSTDGADASSFYLNGTLALANLGTDYPWGMIATSDTNYASWEPIEINVGDGSEGFSITKGNFVWSEANGFGGWLVCDWYHNGPQLFYLNRYYDAKIPSSCSKVQLKPVYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJ03</accession>
    <name>A0A1Q5TJ03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoketolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000648">
        <property type="protein sequence ID" value="OKP00210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJ03"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJ03"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="607"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="91678" checksum="72AE3F942C54C486" modified="2017-04-12" version="1">MGLLSNSNEGKSISAYGEARSTIQGECLTSEEVRKMNSYFRASLYLCLGMLYLRDNPLLQEPLKREHLKQRLLGHWGSDAGQSFTWIHMNRLIKKYDLDALFVSGPGHGAPGILSQSYLEGVYSEVYPDKTEDAEGMQKFFKQFSFPGGIGSHATPETPGSIHEGGELGYSISHAFGTVFDNPNLITLTMVGDGESETGPLATSWHSTKFLNPITDGAVLPVLHLNGYKINNPTILARISHEELTSLFIGYGWKPYFVEGSDLQSMHQAMAVTMEQCVKEIREYQQQARSSNKPFRPRWPMIVLRTPKGWTAPREIDGKLLEGFWRAHQIPITDVLTNPDHLKVLESWMKGYKPEELFDANGKLIPELRALAPAGNSRMSANPVGNGGVLRKPLNLNDFTKYALQDIVPGKTIKGGMANMANFLRDVVSKNMTNFRLFGPDETESNKLAEVYKAGKKVWMADYFEEDKDGGNLSPSGRVMEILSEHTCEGWLEGYILSGRHGLINSYEPFVHVIDSMVNQHCKWIEKCLEVEWRAKVASLNILITATVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNTLLSVMDHCLRSVNYVNVVVADKQEHIQFLSMEDAVEHCTKGLGIWDWASNDQGQEPDIVIASCGDVSTHEALAATALLREHLPTLKVRFVNVVDLFRLISDTQHPHGMPDQQWRAIFTDNKPILFNFHSYPWLIHRLTYKRPGQHHLHVRGYKEKGNIDTPFELALRNGTDRYSLAIDAIDLIQSLGNTGSSAREKFTKFQLQGKKEAFTNGVDPEHIRNWTWPYSKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TK73</accession>
    <name>A0A1Q5TK73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000645">
        <property type="protein sequence ID" value="OKP00616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TK73"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020965">
        <property type="entry name" value="Prenyltransferase_CloQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036239">
        <property type="entry name" value="PrenylTrfase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11468">
        <property type="entry name" value="PTase_Orf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143492">
        <property type="entry name" value="Prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP00616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="84" mass="9407" checksum="A93E60E630088C86" modified="2017-04-12" version="1">MAVKKPLGTLSSEERFLNDICNASKVLGVSYSEKQTRSVLSNFSKGFHRGCVLWGTTDQSTGNLSYRIYERHSIDVLLLPQMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKI3</accession>
    <name>A0A1Q5TKI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotically up-regulated gene 80 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="482" mass="54311" checksum="78D042846D83B8E4" modified="2017-04-12" version="1">MPSFYAPGHGLPPTPPHINSGGRLDEPSFYPVGHTAFPPRYHQSGSEFIEQYSQSLVYAKPNAMAMHPAHPMHGTRDMHSMGHQQSMYGPMATALPPIRANVQLPPMDSAIPPQYRRQEHTQHQHQQHHQQEQQHQSRKEEKATGGVAAHLDYEMDRMSDFVAEMTQGMYDLYNTKITLSDIDFARSISPGTSVPPQFRKYVYQILSSTRLPSSTILLGLFYMSSRMRILSAQRVFQSGSGQIYRMLTVGLLLGSKFLDDNTFQNKSWAEVSNIPVAELNKMELEWLFAFDWKIHDRIYDQQDGFASWRRHWDSWSAKANARAQESSRQTLSPLDTNVVRHHQSVAKPVMSPEGPIPPQYQRSSHIENSWLNPAASEYSPPSAPHSGPNTPDYYSVGPWGFSNPPPPYSQGAWIAPPPRYIAQSAPRSQPPSYHHTPAYGLPFAQSVWTGHGSSCGCMYCAKHMEHYMCNNAFPALQPILAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKN8</accession>
    <name>A0A1Q5TKN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative regulator of sexual conjugation and meiosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_7715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKN8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKN8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF75">
        <property type="entry name" value="AURORA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP00784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="436" mass="48863" checksum="E6DDFC6691BC3C3F" modified="2017-04-12" version="1">MYPTDLPTPPHSPITIPRCYAPEDRVGWILANRLELTGILGVGAYGVVYTALDIHTHIQYAVKALNKSGLDPRQLKYQQREIRLHHRASQHPNVVSLVRIMDSLDCTYVVMEFCPEGDLFSSITDKGHFVGNDPLVKRVFLQLLDAVQFCHSVGIYHRDLKPENVLVTDQGMTVKLADFGLATEDYYTSDFGCGSTFYMSPECQQPHPRPMSCYASAANDVWSLGVMLVNLTCGRNPWKRASLEDSTFRAYLKDPYFLQSILPLSTEMVYILSRVFERDPAKRITIPELRQLIVDCPRFTKSVMTMASTPVQSPVQVLQPQVPVQVPTAWDRLQNLIPPSQVFNMPVDHQQLHMHAQPSVSSSDSSHYSDFSESAISEASALTEDYSDYSDYNCMSPVISVQVQVPDCKVVFPHSICVEQPIPVDCFAAGAPIQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL67</accession>
    <name>A0A1Q5TL67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PENSUB_7555</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL67"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL67"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000150">
        <property type="entry name" value="Class III chitinase ChiA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012953996" description="chitinase" evidence="22">
        <location>
            <begin position="23"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="23">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="333"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="902"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="340"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="624"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="963"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OKP00974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1010" mass="102272" checksum="F3BED50ECB2780B7" modified="2017-04-12" version="1">MAFRRTIAAIAALSSIVVPSAALDVDLKTNLAIYWGQGPNQQRLSHFCQETSLDIINLGFINIFPNAVGDWPGSNFGNQCDGNVYPNSELLRGCHQIWEDIPVCKEMGKTIMLSIGGETAWEYLSSELQAVWFADFLWYSFGPQNEAYTDAYPRPFLTNSVDGFDFDIEHDGGAFYAVMINRLRSHFSEYPDQTFYISGAPQCQIPDTQLSNAISNSFFDFIWVQFYNTAGCSARDFVEGTGSFNFGNWVDVIKASSNPKAKLFIGLPAAEAAANAGYYLTPTEVAPLVETYMELYPKHFGGIMLWEATYSENNLSPDGLTYAESMKEILYSCSPPPPVTTTSTTQTVTPTSKPISTPVHTPSSSPVFSSSPASSPASSPASSPASSPASSPASSPASSPASSPASSPASSPASSTVVIPTSTPAASSSVHVSSSSPVASQSTTPSSSSPIAPTTPAVPSSSKPASSRPASSPASSPASSPASSPASSPASSPVTSSQASSSVIPTSSSVPSSSQVASSTPVHTSSSSTPVVSPSSTPCSSDIPSSSAPVNTPSGTPSKPSSTPVAPTQSSSSVVVGSSSSPASSQPAATSSVPLVSPSGPVSQTSSTPLIPTQSLTASNTPLAPSNVPASSQPASSSVPSGIAPASSSTVPTETSSSQSVGSTSIVSSSSSAPVGPTHTPVTQSPVSSPSRVPISSSASSSPVASSSPVSVSETVSATTSTQSVDQSSTPSVGATGSSQTTSTPGATGTELPTITYIITPTPSVTPAPSSTTQPDVTTTIIVTSYTDICPTGFTTITTTITTTVCPEASATGTASVTGPPSGVATTTPSIPEGWTTTVTVCTHCAATPTTVTLTKPIATTTAQATPEPSSPAGGETWTETWTTTVTYCPRCGPNGSTVTIPYTPSATPTGASGQGEGSDSPKPTSTSTATLVVVGHSKSVGKASSTPYQPNWTPTFAAHPTGTASHVQSSPSGTQEGVSPVYTGAASRSGVTNFIAIFMTVLASCVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TME0</accession>
    <name>A0A1Q5TME0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TME0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TME0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="20783" checksum="F2F4A1FF899D8084" modified="2017-04-12" version="1">MGAVGYHSNLQRLILHSVENDKKERKILDADDIMYLDEQCPKLQFLEIDIRRKDEWPEEIIDALTEGFDNLRQLRLHVGLEIYEKTRANPRAKLEPTLNLVSAHEFGQTFFRQRKSLTKLELIALKTGEKLRHYPEVAPDYTHEENRVSRMFHIWPSQCLNSGFEIKDMDVEVDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMI3</accession>
    <name>A0A1Q5TMI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_7404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMI3"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012547415" description="PNPLA domain-containing protein" evidence="11">
        <location>
            <begin position="18"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="185"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP01414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="574" mass="64824" checksum="7FD05896FF93B799" modified="2017-04-12" version="1">MASWMLALWGIISAVFGMMLDVAQFWKQKLFSWWKSKSPKKRLFHTLATAQSYERWEEAAFELDERLSKDLWRQNPVSRHYDYRLILGRLEALMSARESEDILTLANLLRSGLVRNLGNITSTKLFTHAYAGTKLLIDDYITQVALSIQYVASLQPAPMQTSGFTSQAKLELLHDTRQAFGRTTLLLQGGSAFGLCHLGVVKALHLQGLLPRIITGTATGAMIAALVGIHPESELLALLEGDTIDLSAFDQRRKDHAEESWVRTFVRRMKRLLQKGHLYDMELLEECVRANVGDLTFEEAYARSKRILNITIATAGKTGTPNLLNYLTTPNVLIWSAAAASNASSASTLSPVTIYCKDETGSIVPWPHTKEAIFQPWRHVTYNDGESPLSRIAELFNVNHFIVSQARPYLIPFLRSELNLLDRHQTGWSNLTRSLTRFALVELRHRLRQLDYIGFLPGSLSRLLIDETIPGPNLTLVPDLSFNDLAKLFQQPTRARVADWTLKGERGVWPAISALKVREAIEIELDRGYQLVRRRRPSDAALPTPRYFPNEAVARQRRGCLKSEFEDGTLGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ23</accession>
    <name>A0A1Q5TQ23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="171" mass="18802" checksum="06D369575DBCDF22" modified="2017-04-12" version="1">MRIGTSKELGNSLEHLSSSYSQPWLVRELLALESLGKQYVQQKPLGRMSIANGTYQDNPLHISLFPPYTDATIEFSFLLNSCLDIFEIRRKQTSIDQDLGLLHAIDERLAAYGWLTTTGVKLLIIVDMFGQESVSAGKPTGPAVSGLRDSDLKPVCGKRPSPSLPVLMANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQL0</accession>
    <name>A0A1Q5TQL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000625">
        <property type="protein sequence ID" value="OKP02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQL0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQL0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="313" mass="33867" checksum="27DD330C62ACAF01" modified="2017-04-12" version="1">MDTAVHAEVQPSTSQRTVMHRATSSRELRPMTDLQGIGEPGPANSAAMRVQRGQPHRWSASVFPLTRPMEQSPSMPGAVGRRPFSSSGPPAYTAPPPPPPAFVPITGGFNPVLKPGTMPPGMERRYPPYAGPALPPPTSPPQLHSPGVHYLPYSEAPPGTLHQPLSDPRMPHGPREPYLESPVRLPPIHQATGSPRLAHQPHHAHRLSDPYPTSWSSSGREDISREPRSPAQLQRPISSAFSHSSSHQRSSSLTGSLDPVPRHLGPVELPSPVSLSHGLPATTRTTNPTTEGEQEEPRPIKRRKMALDDMVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TRL6</accession>
    <name>A0A1Q5TRL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_6922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000622">
        <property type="protein sequence ID" value="OKP02850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TRL6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TRL6"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000083">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012208745" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="399"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP02850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="519" mass="57968" checksum="A019C87D884C9F4E" modified="2017-04-12" version="1">MRISLETVTAVLACLSTSYALQIPPDTPLSELISSAKAHLAKGSPRDALVYFDAAVSRDPNNYITIYQRGAAYLSIGKNTQATEDFNRVLELKPDFEGALLQRSRLRARSAHWKEALQDLERAGKKNSEEYQELQAARDAAALALAAEKKGDWEACIAQAGVAIMKANTDLSLRQARAHCRFERGEVEEGVSDLAHVLQISPNLVEPHLQMSSMLFYALGDSDRGLAQIRKCLHTDPDSKACNRLYKRERQLAKSLGKLHSALEARKFSNAVKLMVDDGEDTGLITDVKNDVAEARAAGHIHPAASNNLYVFLVEKTCESYREMRMAKKAGPYCAESLQLVPYSLHGLLYQAQTELDEDQFEQAVRTLNTAREHHPHSQEIQSLLQKAQALLKRSKQKDYYKVLGVSRDADERTIKRAYRQLMKLHHPDKAHAQGVSKEEAEKKMASINEAYEVLSDSELRTRYDNGDDPNDPESQQRGNPFQQGSPFGHGGGQQQFFFQQGGQQFKFGGQGFGGFPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TVK5</accession>
    <name>A0A1Q5TVK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000612">
        <property type="protein sequence ID" value="OKP04275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TVK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TVK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="271"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP04275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="368" mass="41359" checksum="9CF3343BCDA4B0DC" modified="2017-04-12" version="1">MNRLPVSSLMSPPEAKPLDSFHPSSPFAKPDTSMGELMKLPPISADRKRTQSEMDLPSPPVTPYTGAKKRRSETAEQIERDVEVNASRDPLLFPRHDSVGREEPLFGPIPPPAAEALVEQHINSHMAMFENKRNKPTRDEYRLALSCVPIVSTLYNRNPAAWAREELQTLERQMVLMNRYRPPGELEAKLKKIAPAPMKKVAGGTPRVPRTRVKRTPKSTPKHQALDSFEASPPSASKPRALGTNRDDTDFQALPDYSPPLETLGGNAKALKADWKGQMLDLSNDPDRHLLSPAELNLASTLRLSCATYLCSKRRIFEARVRALGVGKEFRKTDAQQACKIDVNKASKLWTAYDRVGWFKPEYFHHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D4</accession>
    <name>A0A1Q5U0D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0D4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="49" mass="5764" checksum="0963AD331B111927" modified="2017-04-12" version="1">MEWKRQDFVDADRLSGVKFVRAGRAHFTWPCILLERPAMNFMILEVGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0F0</accession>
    <name>A0A1Q5U0F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0F0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0F0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012389118" evidence="2">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="230" mass="24870" checksum="BAD005AA4D1B388D" modified="2017-04-12" version="1">MRGSFVARLMALGVASATGVTAASDAYYDSSLNFRPDNVTMNETNKAPYNVSSTFTQYGSEATFETTYPIQFNMTSCNGTKDIDWTAYMISNYYWPGMGSNVSYPDPTLDVVFDSKTAKLTLNAYIQAVQGCDESPKNQNFCDGEVIVEAKMTITLDGTIDSYHSDELNTDRSKPAWTRTVGVNNVTKPGGTSTTSSGSSDKKNGSSGCQYPGAFPLVGSFVALLFSLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U211</accession>
    <name>A0A1Q5U211_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U211"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U211"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="104162" checksum="160B7E5734973139" modified="2017-04-12" version="1">MASIGALPQTLKSITETKITELSKQRVLFNKRKADIIAAANAAPDLRDRARILLDGLSRLKGYPQDALDKDDLDLDVDSSDEDSNEVEVTSPGMGQMYQADHTNIRRFLLQGRYDPSISDSAVKDWITRLENDLRFLELKHEHASFYSKLVTEWLSHLNDANKDPAIEQTDDAASTKSDAGFEHVGRKEMHEQRAQWESLAFTGTTQVNEESINAYLDGLFQKTKLSRQALKELRESVHRFGTHLATKGEWLDVDELQWVASALMKTDLLSNEKAAILKEFMRNKEVLQEVADVLNMRLASLDSWSWGGDGIPIEMRRQLNGKYRVFMDEDLLDSLLLQYLGTTWAVQLRTVFRDFFYSRAWDSVEEDIPKEDLERRKYFLGKGTNLGTAGINQLRKRLYGEKYFLSQLPESRPEGARSYDDDAQVKNALDTKHSLLHLLITESLIQKDQHGEFTAIRSDYQWFGPSLPHATVLTTLKYFGIPEMWLNFFKVFLEAPLRFVQDGPTASTQIRKRGVPMSHTLSDVFGEAVLFCMDYAVNQHAKGGILYRLHDDFWFWGAGATCETAWEAMTEYANVMGLQFNEEKTGTVRMGTARDKQSSVLPSGDIRWGFLVLDAGQGRFVIDQAQVDQHIEELDRQLSSCKSVFTWVQAWNGYFGRFFANNFARPAMCFGRDHIDMAVSTLSRIEQVLFSKASNKASEKNGASVTNYLRSVIAKRFGIRDLPEGFFYYPVELGGLGLLNPYIRLLAMRENIKQTPQRLLQKAAIDDEYAYQVAKERFEREGSDCPKTLKNKKGEHLPFMSLDEYMRYPETYSLNLEYAYKNLIEVPEEKSVSATAGFTKSQNGLKGPKGKASKPGSISATWSKMTPYWRWAAELYHDEMVRTYGSLAAVNREFLPLGVVKTLKEGRFRWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3B1</accession>
    <name>A0A1Q5U3B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3B1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7324" checksum="1716C7B88BEAC587" modified="2017-04-12" version="1">MQFISSLPPIVRIRSFQKPALYPDTPQAIPSIREPKRFMMLDMKQMRSRQFKLLSLSVTGGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U7C0</accession>
    <name>A0A1Q5U7C0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U7C0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U7C0"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP08356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="172" mass="19526" checksum="2BF43733159C50C4" modified="2017-04-12" version="1">MATPTPPRLNHVFHLRCHIGKDTINAGQYRSGPHRRITTLEGGFLRGIPGTRGEGLDATLVAGGSDWILFDESTNTAHLDVRTQGRTKDGQCVYIHYNGYSRIDDSARQFTSRNPDARTTEFGQHHWWTAPNIEVSDPNFKWVATTQFIGRGRWFREGDIQAVEYEIFEVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA34</accession>
    <name>A0A1Q5UA34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two-component system protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5311</name>
        <name evidence="1" type="ORF">PENSUB_5317</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000542">
        <property type="protein sequence ID" value="OKP09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000541">
        <property type="protein sequence ID" value="OKP09339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA34"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA34"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9674" checksum="0BC8FBF4B0950E03" modified="2017-04-12" version="1">MDGMVSHRPGLNGKGSVFWFTARFGRIDLARLNKKLAASQTHALAKVMRKMREIVLHKHIVLVEHSLVNNTVMLKLLQTLGLSPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UA95</accession>
    <name>A0A1Q5UA95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor sap145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UA95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UA95"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="281"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="577" mass="65010" checksum="2FD77B5C44B87ED6" modified="2017-04-12" version="1">MPSATKPNKNQLRRARKKALKAEVSRSPLIVEKDTHISQVPSAPVEPNGETEKQVTPPPATPKDVLEPPAVPVVPVPDDPLWEMYKDLANKFEEGPGENATTKEVEKPEVYFDDEDEIPDEEQELEPKLSKKKRKELNKLSVAELKAQVSKPDIVEWTDTSATDPRLLVHIKAHRNVVPVPTHWSLKREYLSSKRGVEKAPFALPKFIQETGIAEMRDAALEKQEQSSLKQKQRERVQPKMGRLDIDYQKLYEAFFRFQTKPELTRYGEIYYEGKEHETNLRHLRPGELSDELKEALNMPPGAPPPWLINQQRFGPPPSYPALKIPGLNAPPPPGAMWGYHPGGYGKPPVDEHNRPLYGGDIFGVLQPQQNGQQGEPVEKDLWGELQASEGEEESDEEEEDEEEEGSDDEDAADEERETGIHSPSGLASAIPSEFGATENVSGEFDVRKHHRGTETEESVHPRSAYQVIPEKQTSVSGFFGGDRAYDLASSSGAHPVLGVDDQTRKRKKPGDVEVSVDLDALQSGDGLSKERLQDLYETQRQQQHQPQWGFQEDLSDMIAQESRKRLRKEEERRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAU0</accession>
    <name>A0A1Q5UAU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Set1 complex component ash2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAU0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAU0"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="158"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="605" mass="64410" checksum="4CEE2D764F70FABA" modified="2017-04-12" version="1">MASTQAPGSSAPSSNINSPLLPPGNGPLLNGALSDLNSRASPAPASNASVQGADAARSKRNKRDSRKKREAKGLDPENAPPPKKRATVASMARPSSELSILRPLLLAEPRASDQSPPQPRQFNLVTSKSSEVLGQTWDFHEVVDKLTNKNGFRYSYAIGDPGFPHIKYRQTDVEPYHARFSFEDSPAAISFSQDARAVTTSSAWHTARANVCVREGSYYYEARVISGRVDDPQGAPQKGGPSASPRGHVRLGFARREADLDVNVGVDCYGYGIRDVNGEVVNRMRCEPFFPKGEGINEGDVIGMLITLPPLSLHKKIVEGTYDPAVDGDGSDQSSRVPTAANIIRDRIPFHYKSDFCWQQSNVFSTKHLRDYAFNLKETPTFGPPSPLNSEDPTLRTLPGSSITIFKNGVKMGTPFKELYAFLPPASRLANGTNNLGIGERENADDGMIGYYPAVSCYGGGAAECRFEGPWWFGPPEQDEFGGPVRPIGERFNDQIVEDVVADLVDEVEAMFTWGGIDGDVIGNNNTGMDGTASSAIGGSEVLQNGVGAALATAGAAGASDSAVNSNQATPAANPVLEDAMSVGTAGTPQAADAPTGADEDVEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAY2</accession>
    <name>A0A1Q5UAY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAY2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="74" mass="8622" checksum="A66C04C0C9CE4D85" modified="2017-04-12" version="1">MASQEGLYSLYVLCIIIGCVVAVFIGYSLDYIATNGFRDFETTQEMSVEQKRYMREVRDRNTMRLLEQAKWGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBB7</accession>
    <name>A0A1Q5UBB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000451">
        <property type="protein sequence ID" value="OKP09774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBB7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="8799" checksum="61327F00B9304B95" modified="2017-04-12" version="1">MTSHSAWVDHPNTIIVPDEDDTRNLALESDSVRSAGRLLTTSGYVEAAGVLVGSSMNAHETSTSLKRKRTKSKELSDLLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBG5</accession>
    <name>A0A1Q5UBG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_4803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000439">
        <property type="protein sequence ID" value="OKP09807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBG5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="218" mass="24326" checksum="A57F4C7B228D0FBE" modified="2017-04-12" version="1">MHRSPSHRNSSAFSPNANPNEDWTKIPDLAERRRIQNRIAQRNYRKKLKRRLEDLERGAASSASPEASHAEPVARPKAAPNKARSKQQRANKANKATENKAHSVHASTSEGPASYEYYNNTTQDERGMFGQQCTRQLSASPPPVFSYLPLPSYDGHISFTEYGEPVASVGPMVSAQGMYRKPYDEDMSPFGRSYATMAGIDLVPQQHAEQSLLVQSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCK6</accession>
    <name>A0A1Q5UCK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCK6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="85" mass="8205" checksum="3471070E9F751D4C" modified="2017-04-12" version="1">MTTVTSTVTLPAASVELGFNTSVAGAVTATTTTSTSTRNTGAHASSTGTPSLVETATKTGAANEAFKYGNPGLVVGAAMAGLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDR9</accession>
    <name>A0A1Q5UDR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDR9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDR9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="471" mass="53681" checksum="B17FC8C222A6035F" modified="2017-04-12" version="1">MSRPVRSSSCPMDYKPKASDELSTPNGLSRGPWVKSTESLVTPPSTRFDDQYSPRNITGCPSWFGRTVKQRERESPKVKRRKFAKYDSRAGTVTSTYSDSVQSTSSLAFSPPPSEYSEPVSHPKRQALFPPMILSPDEFPSSEYATKRRMKRKKGRDSDDEDQNYVDVQNSDDDELESPVAINRSERDDIIFILSREKAKRMAQAIKVPQDTKMGDEEKNLYLDLATRGCYPVLPSSWKMDFATLPESLFPTGDEEVDETNFPFAIQKASEFYAISALHEILRVPGLVRDCRFLTIHPQEVIRKAIRRYLRWAITDSGVKKTPKTKAVHTIATQGLLEDGKKEETINVVKRVLKRLKKLAEEQKEIYQDTPDPYWPTLVGFCLCGPIVTILSMDTDPDSATWKEVNIGCHAKYMGQFDMSEDDQDVWNSLALAIAVIHIRRTMTRLADHYPYMDGVAQRRRPGDETEDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDW1</accession>
    <name>A0A1Q5UDW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial oxaloacetate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_3965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDW1"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP10662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="310" mass="33837" checksum="F739223A2094960E" modified="2017-04-12" version="1">MSTTTGAFLAGGIAACGAVTVTHSFETVKIRLQLQGELQAKNEGVKKYRGVLHGVKVILQNEGPRGLFRGIGSAYIYQVLLNGCRLGFYEPIRANVTNAVYSDPKVQSLGVNVFAGAASGVIGAAAGSPFFLVKTRLQSYSPFLPVGTQHNYKNSIDGLSKIYRSEGVKGIYRGVGAAMIRTSFGSAVQLPTYFFAKRRLTRHLGMEEGPALHLASSAASGFVVCCFMHPPDTIMARMYNQTGNLYQGVFDCLFKTIRTEGVLAIYKGFFAHLARILPHTILTLSLAEQTNKLMRRFEDRILPDSLREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UES8</accession>
    <name>A0A1Q5UES8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_3589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UES8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="125" mass="13513" checksum="8DB414FA831FF7F7" modified="2017-04-12" version="1">MATAQPSWTYWTNTFVAQLLQPVNCNALFTVGLIIITDIFPEDTKALAGAVFNTAAQFGTALGFAILQVISSVVTENKEVNEGEVTALLAGYRASFWTMFAFMILCTAISGLGLRKTGRIGLKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFM2</accession>
    <name>A0A1Q5UFM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000293">
        <property type="protein sequence ID" value="OKP11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFM2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFM2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="356" mass="40420" checksum="1A0D71217F9DBE7D" modified="2017-04-12" version="1">MSTSTLPSQPLPNETGQPAEPRARGSTTDGLGLDLDAPATTRTPWPERLRELSHLAASSPGTVYIESETEETIHAHLDAVEAILRDPRPALTREIGKCRRRSPGGKASVNVAERKTMTEELEEEKPVLEQENGVDHVAVLAQLMALLREVTLLNGEVERRREESREIRDLFEERCRGLSRTIAELEDEVLELQSDLVEDAVELEGIQGTVHGLHDWIDRIRKEQKLVQTSRTLAYQKSRRSWIGRKGKEDRAVETDSEMMLEGLNAWMRGWRDVEEGFQVRARARQTRRNQRQAQLFQAGEKIGPTQQKVKMTFRWDVIEWLALMRYGPSVALPRGLCVEINPKAPGLVAAWTQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFY3</accession>
    <name>A0A1Q5UFY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFY3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFY3"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="375" mass="40293" checksum="4CE3519E5DAC5FE3" modified="2017-04-12" version="1">MAQAPPVFTPDSEFAELETPRGPKAGSLSITALARFEFEAGKGNDGTKILMIEWEDDDITRSSSEGSWQVSWEGKTTVLPAHERPNDNTRRFYFLLPPNVTIPPVVTLSYEPQTTDNNATRSSTAREVLQLNPLPAIFPPELGATGRAAGKKGVLHTIWAKKRLRVLENEIRDECLTNAEGVALHMAVQEKEWIEGNFGLSPRGVESVASDSSTSSSVYPTGPATPVSPISGRKLTDKLRGLKLQTSEKELAANDSANPAHLLSPQSPDVAVSSFSSFRNIANRAPHSMLTPDTNPTPTPRLQAPSGPESFRPVALHPPESVQEAQQTSETGGFAAIGSMTTIARTASADSGDDLFAKALSPRSPDLPRSPFSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGH2</accession>
    <name>A0A1Q5UGH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGH2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGH2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="163" mass="17452" checksum="D38F71CFF48B9EBD" modified="2017-04-12" version="1">MEPATEEVAPASASASLPQPQSQSQLSSPHENGKTPVVADKNVSLDNNDNENAPDHDNRNGTPNPDSTTLESAASSTKSRPVSSVVPPFWQRHERSVSRASLSSLAQSRIIRLEDHTADPDSETSRGLWARSVAIDDHVVVQGKSGVGSYVVWNCVIQTLDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGL4</accession>
    <name>A0A1Q5UGL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGL4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="216" mass="23729" checksum="4CB538B319460B87" modified="2017-04-12" version="1">MDSIGKTYIVTGGFDVSSREQISTAFEAISLQSPDIHGLVNSAGIAPETLDNLGLPEEDDIFKRIMDVNLYGTWNAGTAYLKHLCTRYPEIIQDEKNREGLGSIVNLTSESVIRADPDMASCNTSKHAVVGLTKSWAKDFVRRGVRVNCVAPGLTDTPMVRNENLDQAMVEELINSVPMKRAARPEEVAELIVFLLSERPFYMTGQVIPIEGGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGT8</accession>
    <name>A0A1Q5UGT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_2772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="506" mass="53730" checksum="817FFC8FA91D6450" modified="2017-04-12" version="1">MAGIMLAIDGSILSTAIPRITSEFNSIDDIGWYASAYLLAQMSLQPTFGRVYIYFEAKIMFLISLFMFEVGSVICAVAPSSPVLILGRAIAGAAAAGMLTGNLAIFGQVVPLRNRPRGMAIMTGLYSIATLAGPTVGGLLTDSRLTWRFCFWINLPFGFIAAVIVIFILHRKPGKLANLPLKEKIGRLDLASASVLIASLVCLFLGLQWGGSTDPWSAPRVWGCLIGFALLCAIFIGLQAHRKESYLLPIWFQGVKGTDATLSGVYMLPFTIASTIAVLVAGFSMTASGHYVPFMWVGSLIYVAGSVLYATLKTNSNAGKYLGYQILAGAGFGAAIQVTFIGVQVVTPAIDMPTVCALEVFFRQLGGSVGISVAQSIFLNTLTSHLRSISGIDPEVVIHSGAIEGSWSNELMTSSTINLVKDALNTAITKAFLLPIGATAVAAVFSLGMERRQIQDDRVLSPGKGTGVSENEVISPDKRPAGESTSNPPLEEHTVCENETKGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGW7</accession>
    <name>A0A1Q5UGW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein RMD8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGW7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="435"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="733" mass="81170" checksum="9B338E759489A122" modified="2017-04-12" version="1">MTPPARGRGTSQRSPTVLVTDSRDQQPAAAPRRRRSPSTRFITVDNVLQYASDVPSMQQRHPPPISRSRRLASAAGGLIASASGGSSASAAASATTKGGRLAAQPRLPPRTTKVSEKLVLLPDTGGVGEPEEEDDDDGEGRDELDLVDEELVQRLARERHIDPEAIRHQLLAQKRLGGDFGVDNEIAPLLAEEETLRKRRVGPERAKSYAERLPKARRTEKLARVTAYCTAQAYKMGSVAAFVKDAHGARTKLYDDCLYTAYHLPLLPGHEGYRLRSSPVLKFPGGRSLLDEEIERNELRDHHEDYMGEVEEHSVVGHGRHEDEHNAGASPGGGNGHGERQEHREGYLDRISEEDARIQEGHENATSADDNGTKHSTAHSEVQQPQETPEPRPRRRRHSSDDGHLLRDRASPPLQAVSSPRPETPARTLYNVAEMFVFSYGVVVFWNFTERQEKDLLADLAFATSSATGTPIPLATMPLHEEDFETEEFHFEYSTEISRPRVYNDMITLRSGDHMIKLAISHGISQSTKLCFFEEVMARQMADAKDVPRRLAMTGKLGMKREEVFRILGRLFKSRVEVNLSSNMLDVPNFFWESEPNLYPLYIAVREYLEIKPRIQVLNERCRVFLDLAEILSDSIADNRTSHQTWIIIVLIIISILVTISEVFLRFGLLHAREGAATNPAAIIARAMGHSPRAVPSGISYSAANPPPGCICPSIPSAGGSDMGMSGIMGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UII0</accession>
    <name>A0A1Q5UII0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UII0"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="344" mass="39782" checksum="EA661DF70D619F37" modified="2017-04-12" version="1">MLFAPSGPQSPRRRNRVKAIFLTIGIVLAIYFIFFAGNESSHSTYHDQPDKYAHKPESVTSPKAAGELARPVVRRHKDMIVASMKSDDTSWLAEYFQDWSRSIYVVDDKNAPLTVARNKGRESMVYLTYIIDNYENLPDIMLFIHSTRYQWHNDDPYYDGVPMLRNFQTSYLQKEGYVNLRCVWTLGCPVEIHPLSDIHREDVHAGEYFKHAFVQLFPDTPVPEEVGVSCCAQFGVTRDRVLMRPKSDYEFYRKWLTETELKDEMSGRIMEYSWHMIFGKEPVHCPNAQECYCNVFGLCNLNCPGPNACDDRYVLPPYSPLPKGWPYLGWNGQPQDPTHGLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIS2</accession>
    <name>A0A1Q5UIS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIS2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9320" checksum="5B5345F479CB48B0" modified="2017-04-12" version="1">MSELVKTAYIRPQNGTESDGFPGISSGFLAAGTVYNNQFTIYPAGSQEQSLLAASRPGGDSGSNMRSGARAQYREKLCFAITSTISFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIV5</accession>
    <name>A0A1Q5UIV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIV5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF41">
        <property type="entry name" value="SFGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="603" mass="68366" checksum="42E503409877E3C3" modified="2017-04-12" version="1">MEVRNAGAPLKAKSWPDSQSPSQSPSQSQSQSPDSQSPSQPPSHSRPPTSEPAPPRKRVRRWHHRGFTGCSTCRRRHVRCDEASPTCKNCTRLGLECDGTQGRMTFKVYGPSQVQDEPKKQKKGSSSPDSPGESCFTSTFAVKCSGDKKVDCEALVVSPLTVPQWSGQTQFRFQQPIFHANLPSLTIQCTDEHYFSHFVNQVSSLLIIYDTHININPYRSYFPDFARSSPSMIGAMQALGALHLANTSVGAERNQHFQQAMGKYGQVVKIFRDRYALPNGQLGMRDFATCLLLCLFEMMDSQHQNWDVHLKGAREIYNLLFYPHTSNAAREAERIAEINHPLRSFLVSLLSYLDVAGACARPGGTIVTGSYWKTLGGGWEYNLGIPSLSTSPLPDDPRLLELRQAWSTMMEVQAAISTFARDKEWMSPDHQDMVYKKIFHQLVVWRESTPISLQLLGDMDLDDETLRRFPYPDMLEYVGCVEAYEKATFIHLHQIAGAGRPGWITDRAYLDMLITRVLTLIRKLSKDVGQLAVLWPLFIAGQETRKEDEQLYVQQTMHELKRFGFRNVDKALELLEGVWFKRRAFPEGWTETLEEIQTNILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJF4</accession>
    <name>A0A1Q5UJF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJF4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66672" checksum="E9EA58E15F4FE33A" modified="2017-04-12" version="1">MTSIRPHEKLRSGCVECKRRKIKRPDKCKYEFKLCWTEGRPFKNKNRQKDKARQQPGSQAQSSASGNVQEWQSEPTIRPAKPAGKSDSRPASSRVPGLKQEADDEVDDEVDRRASLAMSVSTCSDYSVATPRNASFSWVDQSGSYSYQQEPAGMNWHHWQPAKPQRQQKPPPPPVFQHQWQIPQTISTTASPLISSSESRFFLHHYITNTAGVIFPLSLKANPLSESLLQSAMNSSHLLYAFLACSCSHYISLRGDPTGEMTKSVTKFTNAALNGLRKAMVDPNQAGQLSTLTTALALCTSDVISGGMNTWRIHLSGASNLVASVFELQSNDESISTQDPTKLFLIKWFTLLDIFAGVGGLRKSANAGSYWSLPTSNDTGGYIDEWTGYSLDLIPIMSEIGKLARIQRKRSKIMALNDDESEDEAANQQARLDTVEDIQRIENQIYALYDRTTHPDLESNPTTKTTAEEMRHIHRIFLHTNLLHLYRRVQGLPKEHAKPAHAIHMVIELLLKIRPHSMANILCLWPVFTVGCETEDQTQRNIIKDRLTNMEAFGMGNVQSARKAMTEYWDCNVKERWDIWLEDRGFDLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJH1</accession>
    <name>A0A1Q5UJH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJH1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000005">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000028">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein (AFU_orthologue AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000003">
        <property type="entry name" value="Glycoside hydrolase family 92 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF38">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012186058" description="Secreted glycosidase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="271"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="83419" checksum="6A18F8CA7460C7A4" modified="2017-04-12" version="1">MKSFKMLTGLTLLALSAANDLTKHVDVFMGTQSGGNDFPGAARPFGMVKLGPDLLQSGTDSYAGYLPTGKFSGFSLMHEQGTGGAPKYGTVSQLPLVGNITDPLSNITVARSGTDKGSVGYYNAQTADGVEVELSSSARAGIYRYTFPSDSEKNILVDVSHVLPSFRGQGLGQNYEGGNLTIFADGHYEGLGTYNNGWNEAPNWTIYFCGYFESAATNNKTYLATGASPSIEKSGGSVSSTSNSTRVGALFIFSEKEVISRVGISWISTEQACDNVNQEIPAGTSFATVVDEAVSEWNEKVLSKITTTNTNDTSLSLLYTSLYFMHLIPTNQTGENPGWESDEPYYQDIFTFWDLFRCSTSLMQVLQPTAYEEQIRSLIDIWRHDGYLPDARSSNYNGRTQGGSNADNILADAYVKGVRGSVNWEDGYKAMVKDAEVTPQNNPVDHMAPDSSNHEGRGALPDWLSLGYITPKYSRAASRAVEYAANDFSLYQVASGLKKDQDAKKYLNRSRNWRNHWNPKQTSLGYSGFVVPRNTTGFIETDPLKDSGYWGDPYYEASSWAYSWADVHDMQHLIKLMGGAETVVNRLNTMFTEGASGSSGIIFDSTNEPMFKIPYLYNYVGRQDLSVSRSRKVAKSDYSTGVSGLPGNSDAGAMQTWLLWNMIGLYPITGQTTFLIHSPWFASMTIDLGSNKKLKITSTGGDGNGDKDYYVQSLKVNGKPWKKNWLTWDDIFAKGGTLEFELGSTAKNWTMGELPPSPASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJI2</accession>
    <name>A0A1Q5UJI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJI2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJI2"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="159"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="308" mass="36029" checksum="219B887D6309B5E6" modified="2017-04-12" version="1">MDILLDVLDTFVFDRLYASILPDTNTGSEAINSSLLNQHVKVYLPLDPSSWAEASLLKRDNMARQTLSLFLMIWFFGLAMYLIGSFIMYHTVYDKRLLKHPRYLPNQIQQEINQGLSAMPVMAILTAPLFLAEVRGWSKLYNFASEAPFPGYNWLQYPLFICFTDSGIYWIHRGLHHPLVYRWLHKPHHKWVVPTPFASYAFHPLDGWSQSLPYHIFPFLFPLQKVAYLGLFVFVTVWTVLIHDAEYLSTSEIINGAACHTMHHLYFNYNYGQYITIWDRLAGTYRKPEEDAFIRDQNYTGKIIDKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJK4</accession>
    <name>A0A1Q5UJK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJK4"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="101" mass="11829" checksum="9CB507DFB25A4DDF" modified="2017-04-12" version="1">MAPQHFARLTLFTRAGCGLCDTAKHTVMQLQKRRPFEYVEKDIMDAKNKIWKDVYEFDVPVLHAQAVKNGLPREAELSDARKLFHRWTEQEVEKLVDDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJQ3</accession>
    <name>A0A1Q5UJQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000182">
        <property type="protein sequence ID" value="OKP12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJQ3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJQ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32814" checksum="F89DF3A6646D0E62" modified="2017-04-12" version="1">MAPKDKYTDPKLRDEIKEEIHQGDKGGKPGQWSARKAQMMASEYKKRGGSYTTDKETGQSESQKHLNEWTNEDWQTKEGSGTARKDDENGTRKRYLPKKAWEQMSKKEKEETEEKKVEGGKGGKQFVGNTEKAKEARRKVHDDEEERKDEDQSEGESGDEGEGQKGDKGEKKEKGQKSQNGKKGKKNENKQKGPKTRSASKDDGDDHSDANEEEGDEKKSAGTKRTAKQSTRSNKKQKDNEGAGKSKQENRKKDNDEGDGKDDQNVDENEEDYVEDEGDEDEDVDAEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJW0</accession>
    <name>A0A1Q5UJW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJW0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJW0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="268" mass="30351" checksum="533BCC935ED3239F" modified="2017-04-12" version="1">MARRIDVHHHYLPPAYLKESAQLARECNEYGKALREKFPKKYSFFAALPDILDTKAALEEIRYALDELKADGVTLFTRYGDANYYLGHPDIRPIWEELDRRSAVVFIHPTHAVDTNLVNKMLPQPFIDYPHETTRTAVDLITTDTVRKYKNCKIILSHGGGTLPSLALRPAIAMKECGLCDMTAEHFLENARMFYYDLALTDSTFALPLLQKFASPDHILYGSDFPYAPNSAIKYFSKSLAEAEISEEEADKINSGNALKLFPRLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKS6</accession>
    <name>A0A1Q5UKS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_1186</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKS6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="65"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="193" mass="21475" checksum="6F50A967542AC0CD" modified="2017-04-12" version="1">MSTFDIFCAMTPISVQEVNELRATNKKRAEEESRFLAQKLPDQQSQQPPATTSKPQPTNSLFTPGDSAKGAKLFQTRCAQCHTVEANGPHKVGPNLHGLFGRKTGSADGYAYTDANKQADVTWNEDTLVSTHFLLVKRASRGSREIVNHQLFQQFPYLENPKKFIPGTKMAFGGLKKAKERNDLITYLKESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKW8</accession>
    <name>A0A1Q5UKW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKW8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKW8"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="89"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="44606" checksum="CD223591498A0DAC" modified="2017-04-12" version="1">MSLENRDEAIREAKIFVRQVVRNDWEFDSTLYADGKRPGPSTSSTLTDGTLCEGRQVVEWRCREFDSAGSELEPQSSDSDSDSQSPGRASGDPAIDRRRQRRRQIEDEMAWNEGLRMFMARRDAWSGARTQRQIRAKEQKRKLAAMQDQTNGSSDVKGVNAAEDGGAGIPPPTDARAHGETGDTSMLANKAESCLSITEKEKVEEQLRRQDQDEEQSTAPDEETKRKESTETCITEPDQTIGYTPRINTAEIDDKDSGEESDCEEEEELDEPLIPVAPPFISSANPVRATITPSIYPSIYTKVVVQGMTPTIPVNLADLTKAMVQGWKADGQWPPKPAVSSIVLQDDASVPKKAADSPADGAPQSRRKNSITNAMRKVFHMGAHPFHRRGSTSQDAGAGNGANGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULE5</accession>
    <name>A0A1Q5ULE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-mannanase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_1046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULE5"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012502357" description="cellulase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="371"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKP13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="43655" checksum="4292245EBF37972F" modified="2017-04-12" version="1">MRYDLLLAASAALALASPQGHSKRASSFTWFGVSESGAEFGQAHIPGVLGTDYTWPTTSTIQTLRNAGMNIFRVPFMMERLVPNTLTSSPNAAYLQGLKSTVDFITSTGAYAIVDPHNFGRYYGNIINSTSDFAAFWTTVATQFASNDKVIFDTNNEFNSEDQTLVLNLNQAAINAIRAAGATSQYIFVEGNSWSGAWTWVSVNSNLVSLTDPNNKIVYEMHQYLDSDGSGTSETCVSTTIGQERVQSATQWLKDNKKLGFLGEFAGGANSVCQSALTGMLSYMQQNSDVWLGASWWAAGPWWSTYIYSMEPPSGPAYTYYMSILSAYFPSSSGGSTTTSTTTSTTAKSTSTTTTKATTTTVSTATATATATAAHWGQCGGSGWTGPTACASPYTCQAQNAWYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULP7</accession>
    <name>A0A1Q5ULP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULP7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PUM-HD" evidence="12">
        <location>
            <begin position="485"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="615"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="651"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="687"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="723"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="10">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="830"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="838"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="921" mass="99914" checksum="AD472F2B9AEB06B4" modified="2017-04-12" version="1">MAANATGVHNVSDGDAWNVRQALTASLQVRSNRSNMSSSGMNNDRARGSHNNSVGKSFVAGKPNWNNIWGDSNLGNGFGDDQNIGDAAFEGKSGSGSLLSTSESDGWAGRPNLPWSTVNTSSLSMSQNRSGMATSPVQTRANDRSAPALNDAGESSYFSLPRTTGIGTSTGTASHRPYLNSGSEGVSPSGDGMSFNAFPGLRNGDGRRQMSSSGLGGSPVGATFPTSSRPDEMAASMGMGSLASGIPDNMSPPQTRSGLSHMSHNSTSYVPQRPAHSAHPSFYSDNHSVEGRYGSGSIDLTGGFNKLQVSESGYTNQAGAQRPSFMPHASFDGSIPRGKYQTNEDAGYQALVGYGAESAQDVHLAYQARSRGGETGSISPSEYARMDSPLYAGVGGAAQYRNSTGGRVGDEMTFERRLRGFHDQEFVPAQANSLQRMQTAQSYEYQNFHAARLNALQGLYPMAHLGSFPPAALARAGREDPAQVVRSPLLEEFRANSKGNKRYELKDIYNHVVEFSGDQHGSRFIQQKLETANSDEKEQVFREIQPNSLQLMTDVFGNYVVQKLFEHGNQSQKKILANQMRGHVLALSTQMYGCRVVQKALEHILTDQQAAMVKELENHVLKCVRDQNGNHVIQKAIERVPSQYVQFIINAFRGQVNRHAAHPYGCRVIQRMLEHCEEADRESILAELHACTSSLIPDQFGNYVIQHVIENGDAKDRDRMIQIVMSQLLAYSKHKFASNVVEKSIEFGDEEQRHNIISTLTSPNERGESPLLGLMRDQYGNYVIQKVLGQLKGAEREALIEQIKPLLSQLKKFSYGKQIVAIEKLIFDPNSPTAGPLPHTTSTTPPNSHKSSPQPLKRTIPAMEQPQAPFVGTAPPTPPPTENQSTVDDSFESKGLCKSTVTSVSSPETGSTGVPVPVDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMA8</accession>
    <name>A0A1Q5UMA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMA8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMA8"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="893"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="929"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1261" mass="139040" checksum="B90B4F9CC81444B2" modified="2017-04-12" version="1">MFNLFGMRPGNGSPGEMPAEPLPPLQAAVDADAVDTVRELVSTAKPADLTAALCRSCQYGKTAVAQALIESGRCDLNATVDGDTPLFLAARRPEPAIVKFLLQHGADATIKSLNKSRSPAAAQKPPAYTPLHAVVDLHRRRGEVDVSSLEDLMQVLLDAGCDINARNFHGETVLLSCLHQEVALVEFLLQRGADPNVINESGNTALTYFHKPLQYPEWFKALMEHGTRLDIGGDSESGTCLHVFASKCQLGDLSLFKPYVSDWKLIDAKGNSILHIAARTHRHGSATVSELLKLGLDVNQKNHSGQQPIHMVQGSGENLRDILDILCAAGADLDVKDYDGRTALTGAMYGNPRYNAHELIPELIKRGANVNARDHKGNGVLFYMIEPYNFGSENAEFLLAQGADPTVVNYEGDNFLHKMAANLSGQTSDAAILTMIKLLEMGTSPINANHKGQTPLHVLCSQISDHLFAASNVGDKYAIDLLLDAGLRDVLNVPDHQGILPIHLAASVSEILVGRLIFHGADTTAATKDGRNLLHIASMARQSNTVGMLLDHYSSKDLTSLISAQSKDGRTPLHLACLSGRVETVSLLIAHGADIHVEDKNKRLPIDLCALSSAEDQLWQKGDDHGNMFHKVSAAGILVDDDERPSIPSQNKRKREDHKNFGWKGEITSESATLGITRIVRLLVQHGALVPKVQDKHRTSPLFHAVSEGNEEMAAELDRLSKMMGIELEKYRSLETERCLLRSRHLLELFKERFKSNISDKDIMEMVLLGHDQDVAQALEENINLIENKSSLQPVLILLARWGYPELFERLGRLMLDIDPKWINKSGKLFLGVGDMSPSLLAAAQRDLPNLEVMKVMVEKFQADVNIRFQDGMGVTPKVYYSSTMAQARQFKPGDTVLHYLAQGIHWWHEKAIEYLLQHGADPNARDAQGKTPLCVAVKLGELAGHRQIEIVRILLDGGADPNLAATCGFTPLAMSTHSSQLFQMLIDNGAYPSEDHPMELFSALSNFKDDVVSALLGMDLDVNTTTLSDAQPHWHTPRIGRHGRNKGHILRPLQYISMLPFNESNSRNHAVRMIRLLLEYGADPFLHNRSNTQNNDNTLILHEIIADGSIIQPWLELPDLDLERRDPRGQTLLLAAARSDFGTNSYSCKVPLFPHRGGNVGASPWQEGDLTRAMAVYDLGAELTAVDNQGNNVLHNLAGRNYNEMSAQEQFRRTMALFVEKAPELMDQVNSLGQTPLSIAKDRNNQWALDVLEKKDSMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMQ5</accession>
    <name>A0A1Q5UMQ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000124">
        <property type="protein sequence ID" value="OKP13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMQ5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMQ5"/>
    <dbReference type="OrthoDB" id="10030083at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="317" mass="35234" checksum="8328D3E098DCEAE4" modified="2017-04-12" version="1">MPLNNSGSLSQPILHRVGLVGAAARFYQRSYAADYIALGFLAMGWLLIQVFVNPFHRMFSLDNKAIQFPFAVHERVPVGMSVIYAGVLPCLIILAWSAMLHPGVHKTQVTMLGLLVALMLTSFLTDVIKNAVGRPRPDLLSRCKPSRGTADNVLVAWTVCTESNQHILQEGWRSFPSGHSSFSFSGLGYLSLFVCGQMHVFRPRTDLARCLLAFFPLLCAALIAISRLDDYRHDVYDVTVGATLGMLIGWFSYRRYYPPLRSVRCDTPYDKADIGSIEGFSKLDDEEQAISRPLVSRQGSGTEESYQMDHAEMSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMW6</accession>
    <name>A0A1Q5UMW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMW6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMW6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="442" mass="46084" checksum="0A7A954C024BC301" modified="2017-04-12" version="1">MDQCNCLEKAAAHMGVQDVPMNVAYKERPQQSARSSPVLPDSRVSSVPGHDRSSVPPTIRPLPTVSTGKTFKVTINNSPGHDPSTSSSGVLPSVKATVKRTSGVPGHNPQFSVSAFSIAKQAGKTFGVQSDQAVDAKRNSSGVRGHDPQYNASAYLTHVKEAGKSVLASGQNVSRQATSASQPVRATNSRVVSQSNLRGAAAGLPAVKTADKAPGSVGQGVSRQSPSVPQSVNATNRRAIGQSNLRWRVVGFSPTTAAGVSSSVPENTNTRQTTPSSSTSNSSATRCSYLDVRRPRDKMFTHIVDNSVSSTTPVSSRAQSSSILATIGQKSVSQGGLATNNSPRSTAFFQKRSDILSSRARAQVEISPQDRCSSVSSGQNSLVRSISTQLGGLFSSTVSAIAGIGLSSLSFASWSEQSVGKCISLLGSQLMSARKILQSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNB8</accession>
    <name>A0A1Q5UNB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNB8"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="301"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="607"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1081" mass="123999" checksum="01276E88ECC444AA" modified="2017-04-12" version="1">MDPVTAIGLASNVLQFIDFSYKIISGVNKIRSSTTGMTPENERLSVLVEDLNVVTQNLVTDAPAKTENERQLSALAANCHELSEELYQILRRLRVGNKNSKWEGLMVKWHSVRKEKEIEMIERRLQGYQSQILIRLQVMFSHNANKQNHFVNGQLEALRSEGKALQNRTATELDELYESISTLVETIQSNSAQARLHDSKEGPLVELGALLSEFQSVTTSLSHQNKVLERLAFKSMYSREGSIEKAESSTFAWMVDEVSQPTIDQIDLPAGPQDNSDERVQQRKDHEKEKMKQEALRQRTRQEFLTWLNSGRHIFHISGKAGSGKSTLMKFLAKSSRVKKELESWARGRPLIFVRFFFWNSGDTEQMSLEGLYRSLLFETCRQKPDLIPRLFPEIWRDKSLLAAPIHFDEVKEAFNRLIQEASSSKSYFCFFIDGLDEIDGDEIDHWRISHDLQSWTAQADNFKLCVSSRPHVPFVQSFANDLNHQISIHELTREDILKFTMAMFEKDPNFHRIKDTYKDLAIEIVNASDGVFLWARLAVRSLLKSVGYQASEKDLKRKLQLLPKGLDELFDQILGSIDPDDQPLSDQLFLLTTANFCAWKPIVQNAITYSWLEDLDDPGFPGEFPMVSYTEIEIDERLERVSCLLDRLSRGILEMSRKRSREKDGHDYFSFQVQFLHRSARDYIVETRKAQMQARMPEFEVIPGIFRLLLAELKFALPTLHDYRPRVWGNFGGEGGAIRVAVHRLFTVMESAHIKCGYDVPSRFFEEASHIIQHHARATEGGTEIPPADEISDFKGYIWGENLQRVGRTWLTLRESNHSPDFLCEVVCRELQQFLSPDLMRQLKQQNLISGPNLLLVAAQSSSLTLVQQLLHEGRTPTEMVPMEPIRPFDNNWEEMTTIPASQAANSVWIIFLYRLVEVFFSGSLKRSKVRFLECLEEFMLCNVDCNVQFVVRIFPSFGEFDKPGSDMKDTWEDRWQDKGETEERVVFDLLEFLELVGPSNMEAFRAKLSGKRVQGDQSEVVPVYGPTIIHQRGSISKALEAIVAAGKFSQTRAYALCLALESVITPSERLDTPFAFRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPS6</accession>
    <name>A0A1Q5UPS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">PENSUB_13999</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000096">
        <property type="protein sequence ID" value="OKP14473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPS6"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="91"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OKP14473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="33353" checksum="CF2C059F6E7106E3" modified="2017-04-12" version="1">MRWPQWSTESSNDDKELPERKANSSTASSYPTPATNNSDSVLDWGDFAESRTLISTVLLTSGILLAVRFHRSYLRRIPDAPSISPSFLRRRTIFGKVTSVGDGDNFRIFHTPGGRLAGWGWLPWKKVPTTKKELKDNTIHIRLAGIDAPELAHFGRPEQPFAREAHQWLTSYLQNRRVRASVHRQDQYSRVVASVFVRRAFDFPPYRRRDVSYEMLKRGLATIYEAKVGAEFGGEKLEQKYRRAEWWAKARSKGLWKDYHRIGSNFESPREYKNRMGMGDPSDNGGNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPY0</accession>
    <name>A0A1Q5UPY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000085">
        <property type="protein sequence ID" value="OKP14514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPY0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPY0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="400"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="580" mass="65567" checksum="1D06EC43E36A35FE" modified="2017-04-12" version="1" fragment="single">MSLLQDTPSQTATEILWDERLHSDAQWRSWIGHVEAIATKAGIWNYINPSLPEDKVKKEPVDSRDTFPQVSEVLHNATDISALNDAEYTKYSRMVTLFDKERSFNEQIRNKINRIDSLIYQNVAPEHRHILEGKMTPYAKLVRLTQQFAPKGDNRRQRVRNAWRDLVKRPLKGQSMDKWLAAWSSLYEEGKALKIPEVAYKDDDGNPEDRDAIRDFLQAVEAIDEVFVHLWRKDLDAKPKEKVPFQDILAAFRNYRGSKQVAKQNVSAVAFAATLNGRNSSSRGNDISSRSKLGCVCGRTGHVSKDCYHINPLIKPSNWTTSEYVKKRIEENLKKLGSEERKEIEKMMKSETEQPTIAKTAQLTITDEGDIPTDTVAFFTATISSHVFKAALTLPLSTCWIVDSGANLHICNRRDAFESFVSDRRIIALGTGKSVALGLGTAKISVVRPNSGKFEATVQNVWYVPDFQTNIISVSEIKKHGYFFNSEGPYITNSKGVVAHCTEQYGLYLLEEDPLIAPVALNTLKKSAKPLMSVASRQLWHRRLGHINMERLEVLEKMAAGIKIKPELAEPPALTPEKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ56</accession>
    <name>A0A1Q5UQ56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ56"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="417" mass="45407" checksum="FA6FD4EF45AED293" modified="2017-04-12" version="1">MPRNAPRKKSSIFNRSTNPFREVETEPPRVSVDARLPNPSILTLNEPVPLRLMAKKLSDSPETIFLQMLQIELISYTKILAHDLTRQESGSWVVMSRSNMSLALGQPGDPAGTEWTIDPKLWSTLPLPNSVAPSFETCNIERSYELEVRVGLTHGTTGNMKVGLDNQIYPVPRPNIISSQPQLIVLPLRMPIKVYSGIAPPQALLDAMAAAAPLQSPSKPTSGPSRPTSNEANRPPMPPRPSTEPIPADAGAVYDDAPPSYEDAMAENLSPVDGPRREYHPPAASSSRRTVESGADAKSPARTGKAREDGPAAEGSWTPPTRDGRSSSESFDMLPTTPPESHSGSPPASPVRRSQSMMKVPRNQASEESPPQYQPVAETQLQPLNAVERQPSRNNLRPMNLGVPTRKPVPQNSNRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URL0</accession>
    <name>A0A1Q5URL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,2-galactosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URL0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URL0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF4">
        <property type="entry name" value="ALPHA-1,2-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41232" checksum="5041E429C160D72F" modified="2017-04-12" version="1">MDTTTARKRPLVAHPLTPANHEIVKRRVRALEYSTNVDAGSWPSWRPPSKFYDKVTNGVGSLYGEISTASSAHFSNPHSNSKKKIVMVTGSTGNNRMLGMPHIKEMVYENRMTYAEKHGLEFMWANMTSYNLLDGAPIYWNKIPIMQDAFARFPDADWVWWMDIDIIIMNLSLSIHDHVLSPEGMARNILLNHSMTGAGGGETGYRSPSTYEHDDINFVISMDHWGMNVGNFLMRRSEWSDWLLDLWIEPLYISQNWVFPENDGWTHMWQYHEIVRNHTACMNQQSMNTYPDYNILGQHWQPGDHIVHFAGCGGDVICESAWAKYWNLREEVEVSSSVKRKLEDGTAEIEKFQGNVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URP2</accession>
    <name>A0A1Q5URP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URP2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URP2"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="1">
        <location>
            <begin position="185"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="2">
        <location>
            <begin position="351"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="514" mass="57959" checksum="BC44C8DD2FF46657" modified="2017-04-12" version="1">MQKTTERRKAEHASLARVAACLINERFVTVSFAANYITLSYPNAGEPVLIHLQQPFPFQDVLDASEVPQVVTYKGMAVADGAELIRIIGKWRNIDESLLDKVSREFDNSVANMELAYCRQLSLSFDSPAIDWEQALIEAHGLHPWHKCRYPEVGHFLDAKLYFVRLPSDGVTIVGDYKERIQQLLFPTGLEKDIIDDGSIVFPVHQLQLSRVMEIFPQAELLNKTVTARSQSSVRTMSVAGADFCVKVPLALKITSNVRTIKPWSVTIGYRIEPVLRLVEQAVASFGGSLTALREYGAAASSSPHLGCVLRQSLESVESETGDKLIVCVALMEHLHLVWAPASHEEKLDLLREFCRHLFRAVLPSVFIYGFALQAHAQNLLIRLHPKTRAIRGFYIRDFTSFRVHRESFAKACSLDIDTAQFLTSMDSRAKVYKYIHTVIHTHVASMVLKLKLGIMGWRAAREELEKIIPAEDALAKEWLTSPTVEARATLAMQIYGVDKELRLVEVTNRFYHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMP9</accession>
    <name>A0A1Q5SMP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMP9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMP9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO89281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="20134" checksum="D32489BF2E541CF8" modified="2017-04-12" version="1">MIDPLTTLTTNLQLLDTTKSGRSRRSLSVSQNLDVLLILDLSATAHRTHVNHSAQQLYRPTVDNDSVRFRNMIYVNGRVSPAPLRPTGPLGNQIWTDDSQILLFSVCIPPVPMHAFEEASAETALSAIQGTQPFKDNRRPTSGTWWVEIATSCECLTRFAKLQVIVDSARVCQRLRLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNC8</accession>
    <name>A0A1Q5SNC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein LEU3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNC8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO89509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="522" mass="58783" checksum="BEEBD4038CAAC8B7" modified="2017-04-12" version="1">MEKEIADLRRRLSTNPEYPQSREPHEGDDMSQCSDEAFSRRDSTGIDRSRPVSVPAESHPSMATPLTMKRDGSIMSQDENTPWRLEDITLSRARVARLFEHRLLWSTITGVPQDYRVVKALCVLCTWPLPTTSQRTDATFMLSGLMMQIAMQLGMHRPVQAEEFTTFRIEAQGEALKDRLHTWVICNIVAQNVATGYGQPPSTIYDWALEPASLKDADYHLPENLAIRLRIEKFCDRVTKSLYSSKPEPAEFVSAEKLVIVQILESELKEMELQFGQEISAINMIHLRAAELHLRYFVFLSSNPRSDDLTKLFIATTSFLGRVLDLETSPGELIGHSTNYILQMIVSAAFALMKLLKSNFSRHIDFNHGKLLFNGAISAIRRISVMDHDRPVRLADILSQMWNATGPMAAEEDGLQLKVRCRMSMSHVYDTVWRWRQRFRPGKTVEEIQAAAAAAAAANQPISTVNGLPVPDNSLDNPGLMIPTQFDESGAFFSEAGFSEVFDSLNWVFEGIPDSSFAPVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SP64</accession>
    <name>A0A1Q5SP64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">PENSUB_13779</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SP64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SP64"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OKO89713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="185" mass="20571" checksum="8B6EA147745C9364" modified="2017-04-12" version="1">MTLTKINFITGNKNKLTEVRAILGSVIEVDNQAVDVPEIQGTIEEIAKEKARRAAEAINGPALTEDTALEFNALKGLPGPYIKSFMESLGLEGLNKMLDGFEDRSAEAVCTFAFCRGPGEEPLIFQGRTAGTIVRPRGPTKFGWDPIFEYEGQTYAEMEKEAKNRISHRYKALVKFQQWLAEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSS7</accession>
    <name>A0A1Q5SSS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSS7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSS7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005127">
        <property type="entry name" value="PRK06565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF11">
        <property type="entry name" value="AMIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="724" mass="78130" checksum="187690D7055587AB" modified="2017-04-12" version="1">MEISGAREQQQDWCILDASIDELLDALSKGCLTSVELVARYLRRLGTYDASGPKLSAVPILNSSVMEDAAISDSRRATGLPPRALEGIPFLVKDNIKVQGMTVAAGSPAFEHLIATDDAACVKALKSAGAIVLGRTNMPAMANGGMQRGIYGRAESPYNSDFLTAAYGSGSSNGSATAIAANFAAFSLGTETVSSGRSPASNNALVAYTPSRGLLPLTGVWPLYPTCDVLVPYTRTMRDMLLILEVLVGAGNDVLGDFWRQQPFIPLPTVSQIRPPSFQELKNEHSLQGKRLGIPSMYIGGASPVPISTRPSVLKLWRESRQALESCGAVVVEVDFPLVTHYEDCDASTDQWARIDNMPKGWLHTERHELIAHAWDDFLATNGQADCNSLSCVKPDSIFPLAPGSLPGESEADNQLDWTGLVNYPKNKSSSMFQLPGMKKGLKSLEEARRHTLENWMNSLGLDAVVFPANGDVGPSDADINNEASRLAWRNGVLYSNGNLAIRHLGVPTISVPMGTMEDTKMPVNITFAGRAYDDNRLLEFGYAFEAATQHRQMPPLVPALDSDMVSNKIIVTGPSDIQRATVRALPRIKLIAKHKRIDGSTVHLRVEGVVTDPTGIPTAKNLTCYIDGEAQSVTIDGQKWGINLTRSLSDRESAWARWTSPALVQTVIVMTYRGATGIAAELCRHGQNLTNVVVVLAVLNVLVTLAAGPMVYSGKFVEELTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUN3</accession>
    <name>A0A1Q5SUN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUN3"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="740"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="773"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="954"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="866"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="866"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO91575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116977" checksum="3E22FEDB11C9CACA" modified="2017-04-12" version="1">MSFGFSVGDFLTVFEQANKLRKRFVNAPAQFDALSEQVRNLSIVVHDEDLALTNVVLDTQLKNDIRKIATSCGNVLAEVERALERYSDIDTGHGVKKAWKRLRWDQDEVRDLQDRVCYNINLLKGINGRVTRDNVVELLEHQKDEQHQACLDWLSSTGYAEVQSEYASQRQPGTGEWLLESSIFQDWKSKPWATLFCPGIPGAGKSILASVIIEELNTRYENDQTVGIAYFFCSFQTHDDQSQKLESILACLLRQLAQGLPQVPESLKALFQKHKGRGSRPSLDEYFLTFRATLNQCSRAFIVIDALDECHSSTVTRLLDFILELQASNSLNFLATSRLIPEITARFKSKPTCEIRAAMSDVMEYLWGNLSILPSFVSRDPKLQEDIVHKTTDAADGMFLLARLMLESLQHKSSPRKMKQELDALTSVASHYDIAYDTAYDKAMERIQGQVRDQRKLAEEVLSWITCAKRPLTALELRNALAVELGESEFYDDNMPDLEDIISACAGLVTTVSRSSGDVIRLVHATAKEYFERKWTIWFPDAHSRIATTCVTYLSFDVFEEGICSTQTNFEARLHRYPLYSYASLNWGHHARNQPIDEILMLEFLSNTLKVDACVQGLFYIGGYFTHSGYNRNEPPGFTGLHLAAYFGLLSVVTCLLKDFDPANTDLTSTKDSMGRVPLAWAAYNGHTKVVDFFMEHGSNANSKDKTGRTPISLAASMGHLDTLNCFLEHKIDPNTRDTDNRTPLSWAAYRGHLKIVKALLPKGADPEARDEYGRTPLLWASYEGWVEVVELLRERDVDIETRDRLGRTALSWASENGHVVVVKLLLEKGARLDSMDAEGRTPLAWAIRNQQEAIRLLLIAAERSRDGPPRSRYHDTKLESTSKHVVPIFPNNPKSVATGKEQTPTSKPPENNQSNSDNGRCFQCPLCNRASLTSNRHVLQRHVRDLHFPRFRLVCSESDCGRTFQRKDKFMIHMKDQHQRDIHGEEMDAFQKEEPLPEGCIICQRLVTSWEEFYTCIETHVQAPSLAQDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWK1</accession>
    <name>A0A1Q5SWK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000741">
        <property type="protein sequence ID" value="OKO92389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="337" mass="39133" checksum="77B6BE411CB1A4D0" modified="2017-04-12" version="1" fragment="single">QQHSDYGRPQQYSTDIPLPRIIEAVTRQYSNTDDKYSGGLYNDFNTKLVKFYDVCEKIGLQEHQFHVAFSLMLKGRAEKFYFTRIKGKARDFPTMIDMMRAHFDTEENRQRYITEWRETTFPSIIAQNPEKSRPECLEILFETLEKIQPGLPPEHRSETTLREQTINACRGVEECKFSLYRPASTLEGVQAELRSAVANAAFSPRSGQFQAYEEYEMHDQHWTDRTYGGRGRGYSRGGYSQRRGSYGLGNNRELTPFRGSGPRGGYRGSRQGNQGPRQGRCYVCGKPGYWSKYHTGEERRQSLNNFRQQHYFTTGQAATPQDFQIFLNDFEGEEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ72</accession>
    <name>A0A1Q5SZ72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ72"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ72"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF38">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO93329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16770" checksum="380C0D1CDF6546FA" modified="2017-04-12" version="1">MDLRGDTHMQRVLQDESQRLAEDSFFERPTKLETVQAMILLAAYSEKTWFSTALILRTALDSGLEKSLDTLLSQETLPRSSLSASMAERQLVWEVRTWLISFTLELDVASGTGRKSRIGEVDVMKLRRFLDYPLSLPCDMRTGIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZD6</accession>
    <name>A0A1Q5SZD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Riboflavin transporter MCH5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZD6"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="453" mass="48403" checksum="67EB5F95538D9BC6" modified="2017-04-12" version="1">MSAAESKIAAAHGPPADLPSSAASNDSTVMEKFDGEPGVQDSEAPKSWPSEDSPPDGGLQAWLMVLGTWCAMFCTFGWINSVGEFQSYYETVLLSKYSASTIAWIPSLQIFFMFAMGPVVGRLYDNFGPRYVLIGGSILHVFGLMMASISKEYYQILLSQGVCSAMGVCAIFQPSINCIPSWFNKKRGAAYGIVSTGSSLGGVIFPIMVSRMIAEVGYAWAMRTAAFLILFLLGIAILTVRSRVPPKPQNIDKASLVRPFREIKMLLIIAGFVFLTFGIFIPVNYLVIQAMDAGMSYDLAQYLVPILNAASLFGRIGAGIGSDKLGAYNILVSACMIASVLILALWIPATGNAAIIVFSTLFGFASGAYVSLAAAMVVKISPFPEIGYRTGLLFLFSSFGGLTTNPIAGAILSRDGGSYTGMKVFAGVFLLAGSCFILAARFYSTGLVLRAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T056</accession>
    <name>A0A1Q5T056_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T056"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T056"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO93624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="528" mass="59544" checksum="74E5FA27B2BD3031" modified="2017-04-12" version="1">MTGSFVSPSADATISPQLFAPAGLVASILDGFTVWKLILTLFVGAVIYDQFKYHYLKGNIVGPAYKIPFMGPFLQSVNPKFTEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPGYVKPCVVDAAHKLLGKSNWVFLDGKEHVEYRKGLNGLFTRQALSSYLPRAEEVFDEYFKRFLAKSAATKHTPTPWMPDFRELMTALSCRTFVGYYMSDEAVQKVADDYYLITAALELVNFPIILPFTKTWYGKKAADMVLEEFSKCTAKSKARMAAGGEVTCIMDAWVKAQQDSAKYREKIAQGIQVDPSEKPPQVLRDFSDFEIAQTVFTFLFASQDATSAASTWLFQLMADRPEILDKVREENLAVRNGDPSVPISMELLEQLTYTRAVVKETLRYRPPVIMVPYLVKKDFPITDKITVSKGSMIIPSVWPATHDEEAYPNADSFEPERWITGDAEQQTKNWLVFGTGPHYCLGQTYAQLSLMAMIGKASMEMDWEHTATPLSEDIKVFATIFPQDDCLLTFRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0I5</accession>
    <name>A0A1Q5T0I5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0I5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0I5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="447" mass="49162" checksum="91E19A9F5E8C78FA" modified="2017-04-12" version="1">METWQKSADSLKNSKHMCRQSTAGMLARSANKIYQSTDRLQQMHLLEHPTEQKKLPAEQNSNLSSISTTNIPQNSETSESPQDVRPAGTRSLPETSKSSEPEISSKPTQPEISNRSPPSPPSQSSPVSSISSPSTASPQSPSETRTDSTATSSLSVDLSMQKRRPDEQVRALLKFIDHVSSQVQKAKRMRDSKSTQLGEIEHNWINSTIVDADDSARELAALLELCRLDMAKRKGKGKIGSTNRKQWKFQGRGRAEEKQSRLVRYQCRLDRVLNHLENLQIPQEVPAHEPAAKTAAELWVTEPVAKSVVELSSDASPDPVAELPSDMSPEPKTPVAELPSSSATLPSSSGTIIRKPVPFIAELPGDSAIVQIQPAWTAKNIPKIIVTNTPDDSSFTLVGSPDTPNATYESRELNEILSWKETRNSIRLQQSESLSKIVSCMESTRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0S8</accession>
    <name>A0A1Q5T0S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-cyclopiazonate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0S8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0S8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO93881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="411" mass="45484" checksum="69086FBFF9EF914D" modified="2017-04-12" version="1">MVDTYVDEKTGATYDFGVQSFLNVSKAKDFFDRFDISVSSNSSSPMLITEYIDFNTGAEVAFQPPSLTAQITAIAKFLDVIKPWESMLQPGYWNFPDPDSIPEDLLIPFGEFLTKYGLEDGAPIIYSTTGLGVGNMSEVATMFVLQSFGWDMARGLTGQMGLFTPTSGGNQALYNAIAKDLGDDVLYTSTVINSRRTNSGVNITVRNHKTGKITQIVARRLLVAIEPTDDNVAPLDLNSFERDTLAKFTYSNEFTGLVDNSVFNASYYYFNLPSSAAPNHTLVFQDEPMVANFEYTGLEHLFRVMIIGNKTTTALEAKTLAQSSFNTLLQAGRLSGTAHQTQKLNWAAFSAHGPMHARVSVDEVKNGFYQDLYKLQGARCTWWTGGAFSVNFQTKLWEFDEGLIPKILEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0W8</accession>
    <name>A0A1Q5T0W8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_12095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0W8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0W8"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO93816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="275" mass="31735" checksum="9B25F526A5255B83" modified="2017-04-12" version="1">MSVIDTLAWFQPEIGPRLKPSIEFVFRQWSGLTGEELESHLHRIREQAWPLGEFPCIGLWMFLLPGIAAFPQFPTILETVRRPRAKILDLGCGLGQDLRLLAAHGVSTDRMWALDIEPHLWKLGYELFRDEGRMQALFIHADFLKVNIAGDDRFSPLRGQVDLVLASQFLHLFDWEGQLAANKRIVGLSKPGTMLVGFQQGRKRARAYIRPWGMMFYHNRDSFLELWALVQQQTNTQWTVDVSAVALQDWGMQNEDLEWMPEDRTGINFVITRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0X5</accession>
    <name>A0A1Q5T0X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0X5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0X5"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="607" mass="66125" checksum="A405223B17853118" modified="2017-04-12" version="1">MARRLSRNDYAPTWEDNEISLRPADDVSPSSYTDSQAADIPMPTVKKDKRPSTASLRTPRSGKRGSESLNSQKFIPLSMRALYYSVEPATSSSTGSTPNGPVSPKPRRFSNPGTQLVLDPNFPTPQPSPQEYLIKVQTAAFCHDEMRLATALNPQKTTPQIPLHSICGTVISTPTQDSERPEGSKFKIGDTVWGVTSYTRDGGAADYAVAAESELALKPTNIGAQEAAALALPGLTAWQALFRYAEIDPDASVNGGNGIEKGKESVAEYGNGQRRGSPWANGNGNGNGNDGNGQNMFRMDIFGENRYDKYKDRVNGHRNGDGNGQKKSIYADGDGNGKGHSWLRKSVNGINNLVRTASTITRGSGSTNGNGNRNGHGNGHEYGYGRRRSTWQKGGGLRRRRGSQMQLRVLITNARDSEVGRIAVQLLRAEKLFTFPERPWICVTCTPMEADIVRGSWDVDEVIVIPNIPEFDECDFGKIFRSQRWSPVDVVLDCSGGVVFQQAHSPSVVKDGGAVLTAVDPWPAQEPATGDPLDNLGRRKRGLKTTFVPVNPDAISLERIVELVESNMVRGRPEQVTDLMHADRLLRDHAVGAGAVRRGVMMVVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0Y7</accession>
    <name>A0A1Q5T0Y7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0Y7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0Y7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="493" mass="55528" checksum="7840476C4B515724" modified="2017-04-12" version="1">MSNYTSPGRYTMETLILCVAMEILRSTDNHLGPSVLLSLATRLAVHAGYHRDSKHYPEISVFDGEMRRRVWTILSLLDHYISLQAGLPPTTVQTQSDTEEPRNLTDEDLDPAATVLPPARPFTEKTAILFPVALNRIMFADAEIISKVCSVKGVPYQEVLRLDGKLKDLHANIPPPLKFRPLSESIADSPNTIMDRYNINLMYQKARCDLHRRYLAQHRLDPAYAYSRRDCLDAARTVLQHQSDIFDASSSGGQLGYTSFFFSPIVAVHFRSAAMIISLEISCQSRYDLKQHLSLEQRRVILDERKQLSQEIERAYNIWNHLRHQSKEASKTTDALHIMLKVTNNHLQHGATPEQIQPSSPPIGLQAASEVPDYGRWPHPSVMISLYPHVANCFVYFSANSILATPVTLENQLSSTVFDNEHSPLDVDLMDATFYLGQDSLPSTNDTRFAGSNGVVDFYEKYWDNLMLLGGDHSFIDVPQGGADDGHFDQGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T115</accession>
    <name>A0A1Q5T115_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="10" type="ORF">PENSUB_12228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T115"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T115"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="31237" checksum="D59F553EF3B2303F" modified="2017-04-12" version="1">MHELLLFASVPVHQHHGLLQQLAGLTAMQPRHALERRLIFKAFRKPGLITGRVGGSQDLQQASAGDLQRVNKMLNGGMFYTQVVGPVSEKDFAPASKSASAPDADTKMAGMDESKPSVLTQPDNAHVYDYDQQAWKLEFRDIPEAATRSAITTRVMASAALPRGDIEPSMNAWGYGFVTEYLVEGDVFIHNDIVIFLHRVLHYPTGEKEPREPRRNLPALKKMAPLEKTGSYVLQASITVQDGSNQETMKTASQHLLGLREQLKSAVRLEPADRLSLDTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T135</accession>
    <name>A0A1Q5T135_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix domain-containing protein C1B9.03c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T135"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T135"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="36"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="445" mass="50119" checksum="1B5CA5B41DB513C0" modified="2017-04-12" version="1">MAKARVKKRTHLRAQNASAAAAGKGTASSMTKAPKSMVIRVGASQVGTSVSQLVKDVRQMMEPDTAVRLKERKSNRLRDYTVMAGPLGVTHLMLFSKSKTGNTNMRLAVTPRGPTLHFQVENYSLCKDVERSLKRPRSGGQDHKTPPLLVMNNFNSPNATEDSKVPKRLETLTTTIFQSLFPPINPQAQPLSSIRRVMLLNREPSESEDGSYILSLRHYAIATKKTGVSKRIRRLDPKEIRNRDKKKAAVPNLGKLEDAADYLLDPSAAGYTSASETELDTDAEVEVAESTTRKILNKREAQRQRAGDKAEKKAAATPGVEKRAVKLVELGPRMKLRLMKVEEGVCDGKIMWHDFITKSAHEVKSLDKSWERRRKEKEQRKKQQKENIEKKKKEKAKAKANGEEVDEDEDEDEDEDMDDGEWLSDFDDEDEDDEPEEDSDDSMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T144</accession>
    <name>A0A1Q5T144_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T144"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T144"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="9"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="24099" checksum="802D1A8E946238A1" modified="2017-04-12" version="1">MGKKRVLVGYGVDTDEWLAGWVRMVVKTASATSVEKYNIKASWFIPVHSLETFPEECAKVRDAGREIGLHGYSHENPASMSKEQQLEILDKTYKMLTEFCGKPPRGIVAPWWEASAEMVELLLAYGIEYDHSMSHEDCQMYWLRTGDLWMKIDYSKKAETWMKPLVRGEMTGLVEIPGSWYIDDLPPMMFIKNPANSHGDPTLVESDMALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T271</accession>
    <name>A0A1Q5T271_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tat-binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T271"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="583"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1414"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1458"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO94343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1599" mass="176627" checksum="8AB725CF06594D9B" modified="2017-04-12" version="1">MARGGAKRSLEEIVNASDSADEDWSAGSDRLSRRPNRKSQSSPKKKSRHTKKRRRGSDDIVSDDASLSDELSLEESEEDLDDPSVPRNARGTARRRTTQTKKTYQEPSDEEESFGDDEDGEGPEISSPPPKKATVVTLKIRPEILSQPDLMTRRITRRTRGASEDMYALTNSGHHMETVERGTVSPETGMQRRHNSRAFKAPVIHEESVETTEIQASLEILESDVPPEAPEGDTIIANDGDDVEMANEGVVPESEIGDAKNEDDDDEDDEIPTTRRRSRVTRNTDHDGAGEAEPSEDAQPRRSGRKKPSSQRKTQDEESDFEPEEEGSNDDASDSAESAHSPRKASQTRDDDGEDSSAVGRRPGLRKRATQSRGHSEVADELAEELHDLRGGRSKRRAIHEIISEKPRRSRKEVDYRLIRPEHLLPIEDVENDFVTESPSRRGRGGGGGGWQRTLFPTYGPFGGGGPSAILAPPGAPAATGGVESDSSDDEGMHQAKPAGLVPGGLVPQTHSADPAQNTSGTPANFGKVKDRQALADADPLGVDVNVNFDSVGGLQGHIDQLKEMVSLPLLYPEIFQRFHIVPPRGVLFHGPPGTGKTLLARALANSVSAEGRKVTFYMRKGADALSKWVGEAERQLRLLFEEARKTQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDGRGQVIVIGATNRPDSVDPALRRPGRFDREFYFPLPNNEGRRAILDIHTKGWDPPLPSDIKDELAKITKGYGGADLRALCTEAALNAVQRRYPQIYKSDKKLVIDPKNIDVTPKDFMIAIKKMVPSSERSTSSGATALPQNVEPLLRQQLLEIETSLAEILPQRKRLTALEEAQFEEPDDGNGFKREQIMQEFDRSRVFRPRLLLRGGHGMGQQYLAAALLHHFEGLHVQAFDLPTLLSDSTRSPEATVIQLFAEVKRHKPSVIYIPNIQTWFETVGPAVISTFMGLLRSVPPTDPVLLLGVLESTGDDIDAALVHKLFGFSKKNLYDLAAPGQQARSEFFSKLIEYIKTAPSDFPDPENRKKRQLEELEVAPPPPPKADIPVSKKERKAQKKKDHHTLNLLKIRIQPIMDQIKKYKRFRQGVVDESQIRYLWEEEDPNIVTSDLPPDPLSHRPYEKAYDKHGAPGLREVMTGKFYYNMEIVTMEKRLSNGFYKRPSDFLADIKRIAKDARTLGEQERLLRANELLSNVEVDISTIEQAEPALVAECENVYLRELAREKEATERALRLQEEAEAAMSRPGTAGGPNDHSSNPGGLFKPDGDERPVTPTRHGLANVSFANGNGYHNGGGSDLNEPAPHGQSNGSHGDGDGDIFMTNSEDHSGSKDTQVSSFGPSAQPKPPYSHTAPSQQMRRESGMSSFSQTGVVTPMVAGSQPGDYTNEASTTQTTSDKKSSGPGHSVHDHTQSLHGSRDEFPDLHQYPDRDPQQEEHLPDTQQGGSSQPSPRPREYQALGHAEESGPLSGSQSHLKPQPPLFDARASKPTPELDLDLEYVEHLHKQLALQTSGCSVEQLEQVNTCLMDFVWRQRGDWNRTNVAMGVTETFNAVLEDMQSVQEIGAISQNTKIQLENPSFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2E0</accession>
    <name>A0A1Q5T2E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translocation protein sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2E0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2E0"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="267" mass="29455" checksum="DFA5F247445D4390" modified="2017-04-12" version="1">MVDWLSLTVPLAYLGVLIGSLATFSSLYRKRKAQKSATLEAWFPAHLQRDIYFSLMHLDPTSQNEKKTPAVPESVLKAALLRRATEDIRRVMTLRSQKQALSVLLQRGSVGDDLWQRFLRAEKEMEDEVRDVVAEANAYAPGWGQIIFQSANEMLNNDLYRARVAEHQEKVAEEREWWDKKKTSIQEGFMKELNEEKEEGGSTSAQTPATPAKVNEAVPVTTPAKATSVQGSDDDAVLVEADPSVNSPGSPASGGGGGKKKKGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2R4</accession>
    <name>A0A1Q5T2R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_11791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2R4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2R4"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="681"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="447"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO94524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136750" checksum="BC17AEF42AC2F389" modified="2017-04-12" version="1">MGKKRKRPVKDRGPTATSQPSITASPSCFKVAKAPVSQNDQTTTHPVISLYYRQVLTLRQYLLRQLPASSKVRRRRIASLRPSGPPSIAERGNDTGFPLADLLDSTLIGVLKEPSPKIDSDRQRDYRAFTQSQSRSILVSTDTGPTSPQSEVVNFVIETLFARTPGWQKPQHLLTHGYGPYRPTDPSILETSIIGLVAQFPNKNVRTLKEAPWSDVLGLLGENGDDIMMRLLFDCGIFAPVNARRGIYYQLSGLPLSELEPFEQKCAKASESLADRKSASKTVKDDKARKGTNGSNSIIFSRRRMLYGRSGGEGKGQMRSGLGTTHVLNRYKSLDSEAHTVHLINYIFPRQFGLQNVFTSTDNSYGNTPNVVFREPEIRRLIEKEQLRRSAPNGDQAQETDKNAAHTKLPKRLRGQTLELVQRFRIRHSKCPYRQLLDYYCPDEAVGPRKLGTATSPTKRRKENSEPGSSIGGSLVTQLQAKTPSSTGQPNTQSHAPELPVTDENTETKGRPERKVNLTDYATPASAVSAFCRAVILKIVPPRFFGEGSEGLTNRRIIMKHVDAFIKMRRFESLSLHEVCSGLKVANIIWLAPQNFQNPSGSGNAKLALSDFQKRTELLHEFIYYIFESILIPLVRTNFYVTESQTHRNRLFFFRHDVWRSLTEQPMADLKVNMFEQLNPEKAHVMLGKRSLGLGTLRLLPKSTGLRPILNLKKRFLMKSQWGNNKTYLGASVNSNLAPIYNMLSYERERCPEQLGSSLMSVGDMHSRLKEFKNHISRHAPVSVGPKADRLPQLFFVKLDIQACFDTIPQKKLLRLVEQLVSEEAYHVTRYVAVHPSMHGRATRRFLGRAAPLAKQQYFPDLAAGGTTGTANTVYVDTIKQKEHDADELLCLLEEHVRNNLVKIGKNYFRQRNGIPQGSVLSSLLCNFFYAQLEQQVLNFLQPADSLLLRLVDDFLLITTDVNQATQFLQVMHRGQPAYGVSVHPAKSLVNFTAAVDGIYIPRLEGTPLFPYCGCLIDTHTLEIHKDQDRMLEGGASAAATISNTLTVETSRLPGRSFHRRMLALMRPQLHSMYLDADHNTRNVVLANLYTGFITAAMKMYRYMKSLRGRAHPQHPIIIQTINDLVQQTASLIQTRRASRSAPLTCFVQLSHLQYLASAAFRFVLRRKQTRYAPVLHWLDSLWRASRPATNADAVRLLQVVRKGNALFEAWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T376</accession>
    <name>A0A1Q5T376_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_11519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000716">
        <property type="protein sequence ID" value="OKO94681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T376"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO94681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="112" mass="12818" checksum="6F14295508B0FADC" modified="2017-04-12" version="1">MALFFPVEMVYRRPSGHRYPMLETRVAMKVQDMWSLGGPRSTTSTLAMLWEYSGSIEPVGTASTVLPETNPYAQGSNYQDVLWMVAFSNTAFAKRIMQSGFRQEYHSKKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T630</accession>
    <name>A0A1Q5T630_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aorsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_11206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T630"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T630"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012908669" evidence="10">
        <location>
            <begin position="19"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="231"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="644"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO95694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="667" mass="73134" checksum="7801104F4FF141CA" modified="2017-04-12" version="1">MLMRQVYFALAIAALSEAVPAPIKHVLHEKRERHGLDWVKGDRVEGDAVLPVRIGLTQNNLENGYEYLMDVSHPSSAKYGTYWTAEEVHDMFAPSAEAVDAVREWLHAAGIDRSRVVHSDNKGWLAFDAYAHEAEGLFMTEFYEHNHMSSASTKIGCDKYHIPEHLRGHIDYVTPGVKLTPVLKKLKKAKRASHLTKVKPNVEAVSSILNDVSISAKAKSLSSDLQLCGYNMTPTCIKALYDIPDATKSNKGNSLGLYEQGDYFAKSDLDLFYKEYAPWVPQGTYPIPALIDGANFSVPASSSLNGGESDIDIDLAYSLIYPQSVTLYQVDDQLYEPEEVATTNLFNTFLDALDGSYCTYSAYGETGNDPNIDPVYPDTREGGYKGKLQCGVYKPTNVISASYGQAEADLPISYTKRQCNEFMKLGLQGHSILFASGDYGVASFPGDGSANGCLGPDQKIFNPQYPSNCPYVTSVGGTMIYPDQTVKDPESVMHVDLGGTAANFSTAGGFSNYFPQPAYQKHAVEKYFKKADLAYPYYSEFEVNVNTTKGLYNRIGRAYPDVAANGARFRAYTHGFDYHYYGSSLASPLFASVLNLINEERLAAGKGTVGFVNPVLYAHPEVLNDITNGTNAGCDTNGFAAISGWDPATGLGTPNYPKMKKLFMSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6U5</accession>
    <name>A0A1Q5T6U5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial nicotinamide adenine dinucleotide transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_10981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T6U5"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="159"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="268"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO95960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="414" mass="45598" checksum="DC0F2E72689C6F98" modified="2017-04-12" version="1">MRSNGTGSNGAASATAEQPQGFHLDAAPSISHMPVADAPNSDFTTRLQILSTKIPSWYIAPFCGASAGVASGIVTCPLDVIKTKLQAQGGFARRGGQAVETKTLYRGMLGTGKTIFREDGIRGLYQGLGPMLLGYLPTWAVYLAVYDRSREYFYEHTDSWLLSRAYASIAAGACSTIATNPIWVIKTRLMSQSLKQNSEGFRAPWQYSSTWDAARKMYQIEGIRSFYSGLTPALLGLTHVAIQFPLYEYLKMAITGYGIGEHPDTGSSHWLGISLATFLSKICASTVTYPHEVLRTRLQTQQRTAPAPSPEEIAFRGGLKHPHDRGRPPSVSSSDGMPNRPRYNGVIRTCQTILREEGWRAFYSGIGTNLFRAVPSAMTTMLTYEYLRKLIHDYQHEGHLKLKQAEAQAEGEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T867</accession>
    <name>A0A1Q5T867_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T867"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T867"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO96432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="352" mass="38630" checksum="8BA60100313CA48D" modified="2017-04-12" version="1">MASSLSEEDYNAGTSVLATAWALTAAAIIVMALRVVAKIKISNFNADDVVMIAALGFLIPGAACVTISVQAGLARNAVIRHDQEILNIKYYLVAQSLCVISCMIGRIAFIMYLRRLVPLQSKARIVLLILLGLQPLVNVVPVILIFAQCKDIRAVFDPTITDVYCMPVKIQMVYGYTQGAFNTTTDFYLAAFPVYSFWSLKLRLRIKIVLLCLLSMGLFAMVACIIKTVTLHSIDQPGDPTISQAQLLHWAFIEAGLVVITSSVPCLRPLFIAMAKNFSSSPRPTYELTPHAFGHSHNNTRSHVTSRTHTYIRGDANDGWGDGDSARQILEESRSGITKETTVTVQNEEMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8M3</accession>
    <name>A0A1Q5T8M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8M3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8M3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000007">
        <property type="entry name" value="Peroxisome biogenesis protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="383" mass="43231" checksum="EDDC2EBF131A4947" modified="2017-04-12" version="1">MYGSLAYLPRKRAARHRGKVKSFPKDDPKKPVHLTASMGYKAGMTTVVRDLDRPGAKMHKKEIVEAVTVIETPPLVAVGVVGYIETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYAKQHAESSGASITRELERIKKYCTVVRVLAHTQIRKTPIKQKKAHLMEIQVNGGSIADKVDFSRNLFEKTIEIDSIFEQDEMIDVIAVTKGHGFQGVTSRWGTTKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQMGYHHRTSCNHKVFRIGKGTDEGNASTEFDISKKQITPLGGFVHYGEVKNDFVMLKGSVPGVKKRVMTLRKTLYPQTSRRATEKVALKWIDTSSKFGHGAFQTAEEKKAFMGTLKKDLIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8P3</accession>
    <name>A0A1Q5T8P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NF-kappa-B inhibitor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8P3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8P3"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="42471" checksum="06D51B7B748E7DC9" modified="2017-04-12" version="1">MESPPFTGETSRAQPSDDYTHPNRSKGRFRFKSSSSRSTKHHDHHRDHHHQPPSSSSETHRKRRSHSPRTSRSKDESHFHSHTRPSKRRHKHHPQEPPADPTQPSPLSPSAAFRESLFDALGDDEGAAYWETVYGQPIHNYAVPEVPKGPDGELEQMSDEEYAAYVRSRMWERTREGMIEEQERLREDRRRARKRENESSEKERERWRFEREVEESLRRGVERKRRKKNWEGVWKEYVSRWEEIGRVVEKKGAAGGTESKEDGEKEKEGESPPRLRNLLFWPVESGKRRDVNPDSVQEFLRHAPNGDLLGTLKIERVRWHPDKIQHRYSALGIEDEVMRSVTEVFQIVDRMWTEERDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAZ7</accession>
    <name>A0A1Q5TAZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low molecular weight phosphotyrosine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_10218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAZ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAZ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO97424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="19548" checksum="ADEE698EB2E98E0F" modified="2017-04-12" version="1">MAEGVFRNVADAHPIIGEIDSAGTGAYHSGEGPDSRTMSTLRRHGITNYQHAARKVTKDDFLKFDYLLAMDKYNLRDLLDVRESVITSLRRKADPKSAAKNTRAASEAAIGAQGVDAQIAEVRLFGDFGRGGKLHDRVGCGEVVEDPYYGGANGFEEVYKQVVRFSQGFIDYLERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBI0</accession>
    <name>A0A1Q5TBI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystathionine beta-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBI0"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19635" checksum="E8C588929701F2AA" modified="2017-04-12" version="1">MASYQTGSEAYTRQNQTSAPAAPQAAWADKYRGATVEDLDPPLALSVSPNDPVSAALMAAYERDYTHLTVIDAAKRSLLGYLSIPRLKESLQNGSVKDTDSVATAMQRFNRKRGIYQVITMETPLEELEQFFESETGPNGEKREKQQFAVVTDVTRKFVLGVATKADLEEFVKRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBQ4</accession>
    <name>A0A1Q5TBQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_9953</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBQ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBQ4"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="12"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO97662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="365" mass="39956" checksum="B05D175E90064B53" modified="2017-04-12" version="1">MSPSVVSNKTYSIASIPADGIGPEVIEAGITALNALTDTLKTFKLEFKNYDWSSETYKKTGKYIPDGGLEELKKHDAIFFGAVGAPDVPDHISLWGLRLAICQPFQQYANVRPTRVFRGTESPLRKCKDGDLDWVIIRENSEGEYAGQGGRSHTGKPWEVATEVSIFSRHGVERIMRFAFETAQKRPRKLLTVVTKSNAQRNGMVLWDEVAKAVSEDFPEVTVDKMLVDAMTTRMVLKPETLDTIVATNLHADILSDLAAALAGSIGIAPTSNLDPTRQYPSMFEPIHGSAFDITGMGISNPVATFWTAAEMLAWLGEEEASKKLLDCVENVCEQGVLTRDLGGQATTKEVTDAVVAEIKKLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDK9</accession>
    <name>A0A1Q5TDK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDK9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="80"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="586" mass="63977" checksum="56B812D1ED6B4AE1" modified="2017-04-12" version="1">MPLTTPVLSVDADNIHKVDTANAQSLHGMWMVFSKCADYMDQGRRLENLSWRLWTHETFCVEHEKAKNSSAMPKVRSEAADVPELSASIESAASDQAERIEAHIKRPQFSDYRPAVVREDSLASLGRGKEKHITSLDLERMVLNIKERKQLQPLTPVVQPAAPVVDITPRPSTPTPAPPPVSTARQVPTFPRPTPQPCESTESCSTTAPEGNDSDSANATASDTSVSSSGVLPSRAELIKSPSIVRGFSPSHISSSFRSHTNLAANSSPSAATVQQLKPSPLKKKGGVFTLGGSSGDDDESSFEDRMGPKAPQNNTTAGGLKPATSNPSPSKKVASFSDHVDTIRPSKSPLRSDEDAIETDDEVSESAIEDDEDSDWEDSVTESGNASVDERPELFQRVDSRPNLVSRRSLLTMMMHQPARMQGNAFRSSPALQRSRLTSPNGPSIPASPPENEEESLTMRGPDVPRSKPIVMKPPHPQSAAHSPRTTRRNMLATELTESLRRHLLWERQQKSATANAFLKRRHTAHDVKNLQEYPGHKGPHRVTGAVGSSAAGDSHARDKDLAKNGSWTNYTTDYGPWEYHVKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDW5</accession>
    <name>A0A1Q5TDW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Crh-like protein</fullName>
            <ecNumber evidence="19">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">PENSUB_9506</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="19"/>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDW5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDW5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012795840" description="Crh-like protein" evidence="23">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="24">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="385"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="20">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="20">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="21">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OKO98408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="49637" checksum="0D8BCAD96F5667ED" modified="2017-04-12" version="1">MKLALGTALGLLCSSVLVTAQTYTDCNPLKKTCPADTALGKADQTFDFTSGSSSQFAVSGAVTYDSTNGAAFTISKKGDGPLIQSGWYIMFGKVEFTIKAASGTGIVSSAVLQSDDLDEIDWEWLGGNNAQVQTNYFGKGDTSSYNRGAYHANAGNHDGFHTYSVDWTSSQIVWAIDGETVRVLTPATADTNQYPQTPMMIKVGVWAGGDSDNAQGTIDWAGGLTDYSKGPFTMYLKSMKVTDYSTGNSYSYGDQSGSWESIVSNGGKVNGNSADEPTSTQSAPLITATVDSVPVPWSGTHRETSSFVTPNVWPWVATGSPTSTGLPSGWESSSGQIQAPGGGSVSEHCLEPTSTSFVPITKTDPLLSQSTSQFTSLPLVSSSVAFSPSGPKSSSRLVTRPATTSTSTTKNRHQHTEYLQTDDPTTTEVPSVKATSSPTSAPLVGGGISRYRVPTALSMSLVCVLLGGVFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE91</accession>
    <name>A0A1Q5TE91_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE91"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE91"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30472" checksum="8E043609910C202F" modified="2017-04-12" version="1">MFQVKQSPPAPSDGLVGIHHELVNHWCALEDGGSIVAEFSRHKGGLLETAKIHAAVRSDEQAESLSMLDVSVVKIDLSNPYALAGYMIRNDVSIVIHTATSIDAEVTQNLITALKKRREANGKKAFFIHEVVLTHISDLTTFYAQLTEAILQKRALPACQSGYYFTVSHSVRWWDILDRLAAAMHARVLVDEPTTKIWPSDAFAAESLGVPVNFAHSIWDSSPKVVCVNKDLIGWKPIWNSERLLESMDEEINDFLELGMPTSSLLASLGPEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEB3</accession>
    <name>A0A1Q5TEB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEB3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEB3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="323" mass="35808" checksum="DD1CC8BAB91BFDFE" modified="2017-04-12" version="1">MANSHESSRECDASNDSTTIACRGLGHAHYLSALNLILAFAVSLKHKLRFEPDVAYEDLAGLIGHLDTFALDAHDNSVVSPHSKTPWKYMGEYLGFSFAKSNPRKLVKRSKKPLGHLPFEILIHLSAYVESCVKNGTLSLPQYQGQVMTMLSSLNEILTGTERVLDTPLPAAYSIAISQISWVYVMLLPFQLYNFLHWTTIPASIVAAYIIIGLLFIGSEIENPFGEDVNDLPLTAFCSQIAKELDIITATPPPNAEEFMCREENLVLFPLSQDGYPAWRNRTKADIRAALRAKFVTNPAAVDESNMSTMGMSFSTRKTMESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFI9</accession>
    <name>A0A1Q5TFI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFI9"/>
    <dbReference type="OrthoDB" id="5427059at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="51232" checksum="0A8860C85099B9F7" modified="2017-04-12" version="1">MAKPTLEGLPTELLIIILSQISDLDTLKSIVLSSPVCHRVYLTVRHEVLHNLLMEQYGAILDLSEAITAIRSKGLLLEYHKDQAIVVLDNWRRRGETRQSSSTPITRVDRPDGLEEIIKLLQFHKKLHFFLEDYTMNLPRPPWIDPAQWEQELPIKMSDTEKRRFMRALCRLQTHAHIFGPPEGLPRPEDTSLYPQPHHEHIGNMYEDEPAYRLFFGAMPPWEYQEMGCVWSYLLTKYDPVIKNISNDLRDAMKNAKSQFFWNELGDECPPSAVIDTVHDLKTLPDYTENLTSLGPDFLYRVLHAAKIPQRNMVIGNLNTSHWAFIGLGIGSWDNRIPFTEPADRHQVRNFEQFWSTLPPIDQPNLGWRELGLIPHTPEQELEDVLFEENERNLEDKEWSWGYALWDDARLNEWKAPLVRDESLYARRINPPPPLLLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFK5</accession>
    <name>A0A1Q5TFK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="190" mass="20712" checksum="540BD5EF2ADE8EC3" modified="2017-04-12" version="1">MSSATTFFEFEPVDKKGTPFPLSSLKGKVVLAINTASKCGFTPQFEGLEKLYKELKAQYPEDIEFLGFPCNQFGGQDPGSNDDIQSFCQINYGVSFPVLGKLDVNGDQAAPVFTWMKEAMPGALGLKRVKWNFEKFLIAADGKVVGRWSSLTKPETLKDSIVQEIEKAKKAGISASAQKATEGAEQAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG46</accession>
    <name>A0A1Q5TG46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG46"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF25">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="160" mass="18258" checksum="C4F4F18BA4CB176E" modified="2017-04-12" version="1">MVYAMEIYTDGGCRGNGSPWAIGAAAAAFKTKWGKYHGWTRILPSYPPPTNQRAEIVAIILALEQALEKYQELDTNPYLDVTIYSDSKYAVNCMKSWIYKWTNNGWINAAGNPVANRDLLEEASDLDDRLRNEGDVEYIWIPREENEVADRFCNEALDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGZ0</accession>
    <name>A0A1Q5TGZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">PENSUB_8351</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGZ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGZ0"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="108"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="309"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OKO99506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="485" mass="53478" checksum="1CE5FF5EB6157EFF" modified="2017-04-12" version="1">MSAENNETGGSLADRITKPDEPSQPTTTTESTEKQTDDGAGTALQGSSLQEPDYQVEVKLSDLQADPNNPLFSVKSFEDLGLDPRILKGLSAMNFRKPSKVQERALPLLMHNPPKNLVGQSQSGTGKTAAFVLNVLSRVDLSTEEMRATPQALILAPTRELARQIVGVVHSMGQFLDGLSIGTAVPADASARPNRMTASVVVGTPGTVQDMIKRRILNPTRLQVLVLDEADNMLDQQGLGDQCIRVKSMLPRTIQVVLFSATFPAHVHRYAAKFAPDANEITLHHEELTVEGIKQLYMDCSNDEEKYSNLVQLYGLLTVGSSIIFVRTRASAVEIEKRMTAEGHTVASLTGGIEGSQRDAVIDAFRNGEAKVLITTNVLARGIDVSTVSLVVNYDIPEVSGPNRKREPDYQTYLHRIGRTGRFGRIGVAISFVSNREEWDMLRQIQQHFTCQIERIDTSDWDEVERIIKRTIKNSRAQAQFAQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THC8</accession>
    <name>A0A1Q5THC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THC8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THC8"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD-like" evidence="3">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="18552" checksum="BD5158E6723EEAC0" modified="2017-04-12" version="1">MSDNNSSTLGSYVNQATGMAQRAFGAVTGDSSTQAKGEISQTEGEIQNENSHTTAKLGNLTADPNTGAVAKDNSKRADGSWDQTIGSAKEAIGNAIGNENLRQTGAQQNAAGKEQEAKGQLKDWGEGIQDRAQGHLGAVGAAITGDREEQKKFEDIHDEGKVRQRGAEADMAKHQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THH9</accession>
    <name>A0A1Q5THH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-N-acetylglucosaminidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THH9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="141" mass="15689" checksum="0E1118458D1D2D22" modified="2017-04-12" version="1">MGRAANLYDNTNTSVTSVIKSAFEIRPSLENIRVGFQSTELTYDPTVVLHAWQKLYKAASSEPNLWTNPAYQHDMVDVTRQVMANAFIPLYQSLISSWNTSDADSLSKTGKIVIDFLGDLNNVLLTNSNFRLSLGIKSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TI97</accession>
    <name>A0A1Q5TI97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TI97"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TI97"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="49"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="535" mass="58661" checksum="14B09EC81636E5F6" modified="2017-04-12" version="1">MTSVFRNGRIFVPSTKGDNEFAEGMVITDDRITYVGSLDDAQIPADANVVDLDNRVVMPGFIDAHVHILHYGHSLQKVDLIKCTSLEEIRATIKAYAVANPSVPHILCRGWIQLSTNGIALASMLDDLDPRPIFIDAFDLHSMWCNSAALEAMNAHTAPDLPGGCIHRDENGRASGLLDESAVVNMAWPYVESLYSKEDNLAALDIAVQTYTAAGYTGVVDMAMDEGTWEILKEYRRDKHIPFHIGAHWLVPYTEDQEVNFTFVDRAIELKKEFKEPDFCVVGIKLICDGVVDGCTAALLQPYTGKSDPVEPIWPENQLREVVQRADSAGLQCAIHAIGDRAVRQAIDVLSQVGTPGRRHRIEHLEMTTSEDAKRLGELGITASVQPVHSDPALSKAWPGLIGHDRCKRAFAYKEFMDGGAPLAIGTDAPTARHLPFPNLYNATTRRSALEPESTDTVNAHFGITLAEAATAATTGAAYARFADSWTGSLQQGLSADFVVVDTHWTPEKLLEAKVCQTWYRGKNVYNSTEATSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL44</accession>
    <name>A0A1Q5TL44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H/ACA ribonucleoprotein complex subunit NOP10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleolar protein family A member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">snoRNP protein NOP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL44"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP00940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="156" mass="17697" checksum="5E322A489ADD53ED" modified="2017-04-12" version="1">MTKQQVRDPPVGVKKIPPLHPFTTQARILDPHDHKLPPKCILWYVTAARNLQTNPRFDSEHRTPSSDMIADSLEKYTLGADGKRVYTLKKVVDGKVSKSAHPARFSPDDKYSRHRVTLKRRYGLLLTQQPGTSAYNCLCESLHTNIRLPPEEKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMG6</accession>
    <name>A0A1Q5TMG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_7382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMG6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP01392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="126" mass="13187" checksum="EA9069064A990495" modified="2017-04-12" version="1">MSEEDKTSGGSLSQSTPSKPSAAVAPTSPRAESPTTARPLDFDDEPQESGVTSTSNNAPSTQQAQQTATETPPAAPPKPPRPMSPREQSVNTLKEAFPTVELAVVKAILNASNWNVERAFNALLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TML6</accession>
    <name>A0A1Q5TML6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase I-specific transcription initiation factor RRN6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_7448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TML6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TML6"/>
    <dbReference type="OrthoDB" id="4090074at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="103"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="568"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="861"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP01458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="986" mass="110261" checksum="D91BEF43432BAF6E" modified="2017-04-12" version="1">MDEHPQGALLYGHVGRAIYLPETQTWTFSRSFAGNIPISYTGVTKTTVPAPTPASQTQNSSKPVRTADPQLIPHVLPELASQWSSLQDDAFSKVVLTASNICDPQVSSLLDLGYATYHGAEDTRGRVPVAIAASVTGECGNTISFRALTDETAELPLDGFALRVPCIGQTEVTEWSKRGAPIQHICFARPLEEKSVWMAARLQEATTIFRPLYHRDSVPMYIPDDDPAAFTPTLRNSRLDANPVVDISNSHTGGFPHADVTFNPWYPRQLAIVDIRGNWSIWDISGRQRRRRANWSATCSKKGTLPDTNDKPDSTRPRHDGWASIEWVADYSTLLVADRRSLMLYWLAEGENGSSIVELGMTRQSEWILDVQRSSQNVSHFFVLTTSRLLWFDLTTATSNEYGSRTALRPRLAWRHFRDSEDSTLRMSDLLIDGDLHMVLYSKLTELVQVFPCPFLADEPTELVPVPDPFLLDVPSELGDSLTEKGMSVHYSTLLFREIAHTPATVGKSHYNPDMKLAKLFWIDSSFAVHESLFRLPDGKPETEDEMHLETSKVLQLKKRHHVPKKNIDNDENFIVDDWDETVARPLAAVRQKLSSEDDLDLQWTLDLTSIYASAVAKLAVGRSPDNNGPLGSTFDQLILDRETDLVDTSEGWMVTETMLELNHGRPVLEDIDDTALHLTRLVSTIIPETPNEQAPYRYMILPQRFSDVLHGMPLISSDEPPPLDFVRTYDQLVEQWVTSVSHDIPRFTCVMKERVVRGIALDLLLSSLVRISNPPSSKAALQPVETTDEAHPAEVEQMSSQNLPMTLSSSQLPSSQITATQVDNSQGTSETSSKDTTNRPYSGLSAFTTFKQPRPMARNVANLLSHWKPGADPAEYEWQKTSNMLEEEEARRTGGPSLPRRRSRSRRRSQPPTLPEATSMPGTPIAPSIRTWGSQPADALPAFPLPSSQPTLDELPMTQMERGMFGAREVRTNLKPKKKRRAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMN3</accession>
    <name>A0A1Q5TMN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exportin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_7464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMN3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMN3"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000490">
        <property type="entry name" value="CRM1p Major karyopherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP01474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1072" mass="122959" checksum="23572BF3B314FCAB" modified="2017-04-12" version="1">MSVSVQELDNTVRAFFEGKGDVQKQAQQTLTEFKQNPDAWVTVGNILQEATYPQTKYIALQVLDDVIMTRWKVLPRDQCQGIRNFIVNFIIENSGSEEKLRTERAFLNKLNLVLVSILKQEWPHNWPTFINEIVSSCHASLSICENNMAILRLLSEEVFDFSQDQMTSVKARNLKTSMTQEFASIFQLCSEVLNTANQPSLVKATLETLLRFLNWIPLGYIFETPIINTLLTRFLDVPDFRNVTLKCLTEIGGLQIGTPYNYDERLVHMFTETLTTVSNVIPLSLDLKETYARSNGRDQEFVANLALFLSSFFSAHLDLIEKLPNQDFLTHAHFYLIRISQIDDREVFKICLDYWTRLVQELYEEMQQLPITDINPLVTMGVSGLSNGGAPHPSTLANYPLRKHKYETVLSNLRTVMIEKMVRPEEVLIVENDEGEIVREFVKESDTIQLYKTIRECLVYLTHLDVVDTETIMIDKLAKQVDGTEWSWANCNTLCWAIGSISGAMNEETEKRFLVTVIKDLLGLTEQKRGKDNKAVVASNIMYIVGQYPRFLKAHWKFLKTVVNKLFEFMHETHEGVQDMACDTFIKIANKCRRHFVALQPGENEPFIEEIVRNMRKITMDLSPQQIHTFYEACGYMISAQGQKTLQDRLIENLMALPNSAWDQIIAEANQNAAILQDGNTIKIIGNIMKTNVAACSSIGTYFYSQIGRIYHDMLNMYRASSQLINDAVANDGTIAPKTPKVRGLRTIKKEILKLIDTYVEKSDDTDMVNANMVPPLLEAVLIDYHRNVPDAREAEVLNVMTTIIHKLHTLMEDKIPAIMDSVFSCTLEMINKDFHEYPEHRVQFFKLLQAINLYCFQALLKLDGTQFKFVIDSCMWASKHDNREVENTGLTMCFELMNNMAEADVQTSSIFFRQFYIPILQDVFFVLTDSDHKAGFKSQAMLLSRMFEFVETGKIQEPIYAADQAPAGTSNKQFLQEYVANLLHNAFKNLQEAQIKQFVLGLFTYTNDLNKFKTHLRDFLISLKEFSDDNADLYAEEREQAVRDAQAAERTRAMKVGGLLKPSEMDQEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TR67</accession>
    <name>A0A1Q5TR67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000623">
        <property type="protein sequence ID" value="OKP02723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TR67"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="560" mass="63491" checksum="764C8B9297BAC740" modified="2017-04-12" version="1">MNEHNDPATTLLALNEQSEQPKNYSALSRSSGIPSSTLRDRDHGRISKKERAVEQQYLTPQEEKSLLEYVLRLSKNGYPLPVKFLRALAREIARRRSSHMPIPVANEDTRPPGKNWPQAFYKRHPELTSRTLKAIDWKRHDHNIYDKVQDWFRVIKTELDNPAILAENVYNMDETGVLLSVLGALKVLVGREEMCKYRGAAVKRKMVTAVECLSADGRSLNPLVVWPASTHRSNWTTYPTPGWHFACSKNGYTDSSINLYWIQHVFDPQTKARAGKRPRLLISDGFAAHESLEVLKFCLANNIIPCRLPSHTSHKLQPCDVGVFSALKTAYREQVELLYRGGANAVRLEHFTSLYSRARSSAVTPRNINAGWSKTGLFPWNPDRVLKDIQPPPRASCSNRGNVATVVRYSDSVELLQTPQTPITADGLKSLCRKMQKEARGWDEDSKLLVNRLAHAAEKAFADRALLRNDNDRLLVQNNEKRTRTSKPARKVGNAKVMSYEDIIEAQRNLEAKKASQGGKRKKTSSSGRRAKRSCSDDVRRAEDEIQTWGFKDYCSVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT09</accession>
    <name>A0A1Q5TT09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT09"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP03370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="29622" checksum="75842E6DB7A4E806" modified="2017-04-12" version="1">MSAPKGRLQGKNAIITGAAGGIGLETTILFAREGANILLADISEPALAKALAKVKEVVPTAGRLETIRCDVSKEADVQAMVESQDSWGGVDVIFNNAGIMHADDADAVDTPEKIWDLTQSINVKGVWFGCKHAVLSMRRNKKKTGSVINTASFVALMGAATPQLAYTASKGAVLAMTRELAIVHAREGFRFNSLCPGPLNTPLLQDWLGDDHAKRFRREVHFPSGRFGEAIEQAHAVVFLASDESSFVNGTDFVVDGGLSKAYVTAEGPAPAAPQNLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT18</accession>
    <name>A0A1Q5TT18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol 2-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_6890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT18"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT18"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="100"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="325"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP03387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="532" mass="60397" checksum="27E19B2D141D7677" modified="2017-04-12" version="1">MLLNQGRIERFLLDSIQQHSDLQVERGVIAETFEYDDDMEEDPNGYPITVKLRTLSDEEANPPGLRINETNHSAATIGVSRGSLLPDDWNELITKSKAKQTKTEIVKAKYLIGCDGAHSWTRKQVNIPLEADIRRLGTVTHATGTILFIPRERSMVRLYVPVQTIESTAPGDGRFDRSRITLEMIKGRVQVIFAPYTFDFQICDWWTVYQIGQRIAPTFSKGNRVFLAGDAVHTHSPKVGLGMNMSMQDGFNIGWKVALVASGVAQPSILATYDAERHCLAEMLLDFDRHWSGLFTEGEGEGKTQNMIKVVELFEDFADGRKSFYGASELVWKFEDDEDPPAARNLIPGERFPPVKLRMQADGNLRWTTRLLESDGRFRVVILAGDMRTATQKNRLLTLTQRLSGSNDQNGAVLHRYVPIAGRFECAIDVMAIHSAPWTEVEYFDFPDTLRPFDPVRGWNYDKIWCDDACPWNRDCDGKGYERWGVDRMRGAMVVVRPDQYIGWVGELEEVIRMTCYLDGVLIRKAANDCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TT20</accession>
    <name>A0A1Q5TT20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000618">
        <property type="protein sequence ID" value="OKP03362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TT20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TT20"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP03362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="255" mass="28159" checksum="1D03A0F27E86F206" modified="2017-04-12" version="1">MHIQSIPMWTGKGNNYAYLVTDEPSKKSVIIDPANPPEVAPELKSQISAGKIDLTAIVNTHHHWDHAGGNDEMLAQFGKLPVIGGSNCKSVTKTPVHGEEFKIGERITVRALHTPCHTQDSICYFMQDGEQRVVFTGDTLFIGGCGRFFEGNAAEMHKALNQTLAGLPDDTKVYPGHEYTKANVKFCLHVSQTEPIKKLQAFAEANQQTQGKFTIGDEKLHNVFMRVNDPEIQNVTGKTDPVDVMAALREMKNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TTN2</accession>
    <name>A0A1Q5TTN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000617">
        <property type="protein sequence ID" value="OKP03569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TTN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7089" checksum="B6F3E887F5FC7DA0" modified="2017-04-12" version="1">MLVDGVDGVDGVDGVDGEDSEDGEDGEDGVDGVDGEDGEDSEDGEDGEDGEDGEDGVDAALINGSGETLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU76</accession>
    <name>A0A1Q5TU76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU76"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU76"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36533" checksum="E9F08E4AA1E3FECF" modified="2017-04-12" version="1">METLQQSPFSNDQYTVGWICALPIELAVAKGTLDEEHGAPQTPTAEADQNAYLLGRVGNFKVVVACLPNDQISSVSAAVVAGDIVSTFPKIRIGLLVGIGAGIPDEDNDSRLGDVVFSSDKESGGVVVYDFGKRLADGSFQRISILNRPPRSLSSALVQLEAAHMTRETHISHYIDTMLQKHPIMRKAGYRRPAQDTDRLFDAHYQHSAGRTCKGCDPSEEVSREPRQDKYPLWTIATGDSVIKHAPTREELKQTHNAICLEMEASGLMNNFPCLIIGGISDCADSHKNDRWHAYAAAAAAGCAKEVLQYVLPKEVDLASAAKDVLGQGTNFETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUC2</accession>
    <name>A0A1Q5TUC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYB DNA-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUC2"/>
    <dbReference type="OrthoDB" id="2350934at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF24">
        <property type="entry name" value="MYB DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP03832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32981" checksum="54301970CC34AAC1" modified="2017-04-12" version="1">MIALQNRPILPPAKVDISLLLKPQDEEEAPGIHPTPLYPPRTGFSIPPPVPAAPILTTAPPILTGPPAVAPSLIKSAPGLPAKRLQPAHTAESPAKKQSKWSPEEDALIIELRGSGMKWEDISKRLPGRSAISCRLHYQNYLERRSEWDEDKKNKLARLYERFKAEMWSKVAEEMAIPWRAAEAMHWQLGEQEMARRAGVVPFSLSSTAIDPPTTRTRRASTSLARPRKSSTSRAIPGHLPGLPPQLPSLEELTAGVPAYAPPAPPPPREFYGLGRPPDMGIPPPGLMGPGPHMGMPPRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0B9</accession>
    <name>A0A1Q5U0B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0B9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0B9"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000014">
        <property type="entry name" value="5-methylthioadenosine/S-adenosylhomocysteine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="55"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP05901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="462" mass="50086" checksum="73F9C6D10486FF09" modified="2017-04-12" version="1">MLYTHATIITVDGSRRIIDDGAIRVNGDTIADIGKTAVLKERYPDDEEHDLSGRIIIPGLISTHMHTAQTLLRGTADDLELVSWLCERIWVLQGNFTEADGYAAARLSIGEMLKSGTTCFLESMFADRYGFDGLARAVEESGIRGCLGKIVMDIAKYAKDDAWAMHPGLVENRETSLLGTLKMWEKWNGAANDRIRVWFGARTPGGVSDALYKEMTAISREKGIPVTMHCAEVKADRDFFASVSHTPMSYCDSVGLLSPSTVLVHMVHLDDSDIKTLAASGTHVAHCPTSNAKLASGICRVPDLQQAGVNIGLGTDGAPCNNTCDLLQEMKLAAIIHKSISYDPTAVPAETVLEMATINGAKALGLDDRIGSLEVGKKADFVAIDVRGIHNQPWHNAASAVVYTATGRDVDVVVVDGKVLVQNGELLTMDEKEIVEEAKKRSREVVERAGLSSKVKGRWPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0C4</accession>
    <name>A0A1Q5U0C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0C4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U0C4"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP05911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="401" mass="44049" checksum="6A9EFCA907E8B686" modified="2017-04-12" version="1">MVSFWPWKGDDNSPASFEKTLSTLSTKIAQSTTRLDQQRQTARRFKALWTLYSTFAYLFYSIVLALVLGWESWGVKEYAAIAGGPVLIYGVRTAGARLFEYRISRSQRHVDELSKQRDETIEKLKVATKYNSTQQLLEKYGGESPKTSPNAKGGPDNRKPGTPSQKQQQQQQQQHVARTGLPPPPTANIRRPPPPGQSPIGPGNPPSSPPNQPPQQQQALPNTPSTPPIPQQFTDEPGFAPNAFPSSGQYIEQPHWYDRLLDVLLGEDEMQPRNRMAMICGSCRLVNGQAPPGIKTLEELGRWRCGSCGAWNGEVSETTKILSTLRQNAGPAEGAYGPSSTAEADVQAGDVSDEEMMVTVSEEDEQGDRDSDQGGEGESDQTSAEPKAEPVRRSKRGKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1A6</accession>
    <name>A0A1Q5U1A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine-cytosine permease fcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1A6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1A6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP06263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="250" mass="26533" checksum="C32DC7D8B6AA0719" modified="2017-04-12" version="1">MGNDCWRLCLLYAPTGSTASSRLVLFGGPLCPFLIDDDLGTAFGGAIPSIPSWTSAYAAGGVGGVLGEILISRLGGFGRFILILLGMSIVTTSARDMYSMSLFTVAVVPWLGRVPRVFILCGAAAVMVGVAIAASRSFLSTLSTLVSIAGYMTGPTVCVFLIEWLYFRKADPSKLDPTIWNDAAALPSGIPAIISSLVPWALIITSMSTGWYVGPIAMRISDLAYELGTVTAGLLYFPLRLLEVRWLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3D7</accession>
    <name>A0A1Q5U3D7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3D7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3D7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="168" mass="19122" checksum="C857F45EC9A7F01C" modified="2017-04-12" version="1">MANFNGRRAPNFAQYLDDLNAIPSPYDQAVQQRQQENTFNLDEELALFTNTEFFDFEKFTDLGLPNFDAVDQKSSPVESIADQATQNADMKFLEFLNVAQLMSWLDVVFNMLDVPISTPGTTIPFFWTLPTRVIGVLPLGLQDIHVEWRVQILSRACDRCRAIGLVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4D5</accession>
    <name>A0A1Q5U4D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4D5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5045942411" evidence="2">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="44051" checksum="072470A95CD4839E" modified="2017-04-12" version="1">MSATMLSIFSVFLLICAAFAASITPPSQDPWYEQPSNISDYVAGEMIRSRSVPPELESFLALPLNVSVKAVYQYLFRTTDSLGDAVASAVTLIEPYNSDPSKLVGYQAFYDSANIAAALNLGWWVFTTDYEGLNAEFTVGLQSGHAVLDSTRVVLDEGPSVGLSRNPRYALWGYSGGALASIWAAELQSSYAPELNYAGVAVGGTTPNTTSVLQTINTGSHAGLAFSATYGQSKAFPNLTNWLSESLVPSKSAQFYSIASGCLSQATSQGSGQDFFTYFKNGEASFNEDVPRSIHKWSGQMGLHGTPTAPMFVYKSTGDEISPVEDTDDLVKKYCGAGARIEYHRDLVGTHETEAISGSASALEWISDRLKGKAVESGCSTKNVLLSSLSAETVALLGEELFALLQAVLGGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4P0</accession>
    <name>A0A1Q5U4P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Versiconal hemiacetal acetate esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4P0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4P0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF166">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="35"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP07414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="26697" checksum="E171121176C96FFC" modified="2017-04-12" version="1">MTAHTEDIKVNSELTVRTYTPTAGPAGSNPLPVGLYFHGGGFCCGDLESEDTFCRLLAERLPCIVISVGYRLAPEHKAPAQLDDALEAWNWAYNNASTLNGDRGRYFTVGQSAGGNLALAVARRLIVLGRKDEVKGIAAIAPFVVHPDGVPSRYKTLYRSFDELGDGPVNTKQAMTQFYAVSSLTKVITEATQAPPSDPDVYVLNAEADLRQFPPTYLAVCGIDPLRDDGLIIHDALKTAGYILLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U814</accession>
    <name>A0A1Q5U814_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_5600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000567">
        <property type="protein sequence ID" value="OKP08613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U814"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U814"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="190"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="377"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP08613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="480" mass="53415" checksum="EE8C26A7BE0FEBA3" modified="2017-04-12" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQAQIHQQREQRRHDIKTLKYERIINDGLLSRIDKLLDSLKQHEDSSASPEQFIFQTIMEFASNPTEDQVPPPPEGVHTHEKEQPKYSQMMSALVDQVKKEFGDSKPDNMFKAYITGVQGHKDKVQGLQKELLTRLAQLEKEESSKITSEGLHDGFNSSYVPKAEPKAKAAAPAKTSEVELLNPGAGSSSAAQAEEDDDDDPANIEISPLAKRFAKLKANDYTAYQRFITEHPEIVAEKETDGLLVEAFNSQLKGEEAYARQCVHQGLLLQYCRSLGPDGIKLFFGRITTKEHRAATLFTNDVNDTYNRIKTRAAELSKEKSNDPAGVEQIQLHAVDPNTKITINIPAANSEEPIEIEARKIFDAFSPELQKALLSESLDEVNKVLGKMTVEEAEVVVEQLGESGMLSLEEGIIDGTTEEGQKKLAEIEAEAKQDVGEAGGDVTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAY8</accession>
    <name>A0A1Q5UAY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAY8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP09629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39419" checksum="3FECD7D32C06FC71" modified="2017-04-12" version="1">MVSTQQTQPPGARDRNDISPEDMIPGTEVMREWEEYDATQLSRDGYVTGYFLGLFLGPVIAGNIAQSDPATHEDNHSQNAEKQETSNNDIPKEGLEHVESADGHARAVGHGRPSKSQFRLWQTPAADWKKFLIRDIISPLRVFPFPIIFWAGLNVAGPANLLLFWNLTESTVLGAAPYNFSPSAVGYSNFAFAVGGIIGLLTAGPFSDWVAMKATARNGGIREAEMRLPALIPYCITTIIGIVIGGLGYQKVWDWPIILVIGYGFSGLCVTAVPTIAVAYAVDCYKPISGEIMVVATVIKNTCGFVMSYWVSPLAARTGWLTPAMVEFALTVGPLLLGIPIYFYGKTLRRLTRNSVVHSYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBM7</accession>
    <name>A0A1Q5UBM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000437">
        <property type="protein sequence ID" value="OKP09884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBM7"/>
    <dbReference type="OrthoDB" id="4358431at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="14778" checksum="4A05C1C42F25EF71" modified="2017-04-12" version="1">MSPYTRRVFRRNANKICDLDKTPLLDPSNNVKKVQEARNENCRNRYQNSERDSEPNSQMMIRMRLRPGPNWPRLSFITVLEEGIKKKSGFQKIRNHVENAHYEEKRRDWMRRLRPMAHRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCE5</accession>
    <name>A0A1Q5UCE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000390">
        <property type="protein sequence ID" value="OKP10144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UCE5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="143" mass="16307" checksum="9A91C42249B00EA3" modified="2017-04-12" version="1">MTESRPARPEISCSWQSSKGSKPIESLEASPLQHHPNHEQVRKDLVKRGQKFRDLAGSHTRHCKGKGFFMNKGKVVEVNVNSRVAVDAAFFHEKQPNYSRPSLRDLGVKDKNGIAVFDIGAILMEDASERRRRCKETVWTHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD98</accession>
    <name>A0A1Q5UD98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000347">
        <property type="protein sequence ID" value="OKP10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD98"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="546" mass="60995" checksum="2CE70B393689D593" modified="2017-04-12" version="1">MFRDESKSVVRKAKAEAGSSASSTSSASSARSRQKRSPTRSSRIVSPDGSGTGSLPSERDLPLVDPAFDFIFDMGPPLDFAMLDPWSIPLEVQPPPEASKQEAICYFLRGNAIPGSLWMEDFVNRFLAEPGAASSQKAMQSTIIAVSSAMLCRVRKMTSLKDLAQREYVAALNHLNTALADVEEAKTNQALGAVVLLAVYEVVTSRAPRDIDQWTNHITGATALLDLRGPEQLKTEIGLRLFLHLRYQIIISCIQRDARVPQSLLDCTEYAMFLRPGEAHGNRLIMIIGRLSNLRVDIQEKILTDNREIISVASSIEADLIAWLAALPPDFTYETHTKSPYDFMFQERCRGLALYDDKFHEYPSLWVCNTWNQYRCARILVSEIILSHIRKLSESNSIRLLSDEFRQHCKTIWANTRRLAVDICRSVPYHLGAHLKDASPNFPPPESYMGGLMLLWPLFLAGIVENPNHALRRWVIQCLKMVGHSYGFDQALALMDIVAVDPGILREAAARAVEEEYASPEESVSPAEELPDLHWSQIPSSAETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDK4</accession>
    <name>A0A1Q5UDK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">PENSUB_3855</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDK4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDK4"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 22" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013270866" description="chitinase" evidence="22">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="23">
        <location>
            <begin position="44"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="19">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OKP10552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="342" mass="36435" checksum="7DB64D5930BC12D8" modified="2017-04-12" version="1">MAISSYLKWAALILATAQLGAAQTYTSCNPLNKTCPADTGLAKWEFNTDFTSGSSAFSKWNTTAGTVESTSLGAKFTISEQGDAPTIESDFYIFFGRVEVKMRAANGTGIISTTVLESDDLDEIDWEQISTYDYSIETDYFGKGNTTSYDRATTVNVTTPEETFHTYTVDWTSSRIEWLLDGEVVRTLNYADALNGKNYPQTPMRIKIGIWAGGDPDNGEGTIEWAGGETDYTAGPFTMYVESVKVINYNPASAYKYTDKTGDYTSIKATNGTTSTNLASTSSSVKASSASSSSSSKSSASSSASSASSSASATVSAAGSISPYSVFATLMVAFIVCVSRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDQ0</accession>
    <name>A0A1Q5UDQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDQ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDQ0"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="275"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="699" mass="77847" checksum="AB715D5EFF860F2D" modified="2017-04-12" version="1">MAGKKAISVSQFAEHFRRAWLGTQEKFYSGRSLDRNDFNQLPRKLGLAVSGGADSMALAYLCRQLERSALAGKISVTAFVVDHRARAESSQEARTVAGWLHAMGIKTEILELDWAQFAKQDSSGHAKGNSTLPSAFETHARHLRFRALGMACRERDINALLMGHHQDDSVETTIWRLSSGGRGAGLSGIPEVARIPECHGLFGVSESGSSVNLSDHGSHGRAPVQLQVDDKNKGSIIFNPQTIQQNTGKQKQKSTSTSSPKTSSPLTLSDVPVATGGIHICRPLLSFPKASILETCRQNNIPYVSDPTNFDPTLTPRNAIRSMLASNSLPRALQAPSILSLIRSSQSFLHTSTEFSNQLLASRCRILNLNLKAGIMVLQIKDLPAFLDPLQSQLPASRLFQIQSLTLRRITEIISPFHGNHFPLRSYEPFVPRIFGHQDGQDGSKESSFIPGQNFTLGGVMYHPLAVKHQLGPVPGGKNLWLLTRQPFFKNKGPVTRLDVTFAPTKSHKSNPGTTLSPGFTPWTLWDDRYWFRFKVTPTSKNQEKRSSETRNMTLLVRPLVKTDLQRIRVDPKLIPQIKRNKKWFSLVIHTRLRNLLAEECPGSARFTLPVLAIEKPSDMPWSPDYEHDQLVALPTFDFQLDALSSQRGPNVVEFTYGGEKWKVTWEWMYKMVDTEAIRLMGGPVKVEAESASVHNNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDT1</accession>
    <name>A0A1Q5UDT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDT1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="22309" checksum="E3418965420E0D1E" modified="2017-04-12" version="1">MGFFDHLQKGGAFSLQAKKTQVRKVVQTKPAAPTRPTAQTPDSRSPRVPSSSERSRKAHALTARSVSSDADARPSKRLTTPSRPRKRPTPETRLSSDDDDDVGDSDTSFEVRKRARTSASTEPDPERRIRSVKAFSEEGSRPFKMVHAADITSGQKAGKFKPAFGAASKPKEILLQYPSACQKERYVCQVASLILKRLTDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE12</accession>
    <name>A0A1Q5UE12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein rad5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">PENSUB_4010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE12"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008094">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="528"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="921"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1028"/>
            <end position="1207"/>
        </location>
    </feature>
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            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="400"/>
            <end position="428"/>
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            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="76"/>
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    </feature>
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            <begin position="95"/>
            <end position="113"/>
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        <location>
            <begin position="400"/>
            <end position="417"/>
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    </feature>
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            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00007025"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OKP10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1225" mass="135852" checksum="BAB94C0CF53A3E49" modified="2017-04-12" version="1">MNEDLEHRPAKRQRFFVDSSLSSPDSTAGIGDASLPRHFPSLDEQAGQTNLPETPSKGGTAACGLTSPINGLSSTETPRHDTAGDPSTTTSPLHSRPAPSEASAPPPTQSSSSNGFDADLFFSIIGETLPIESLKIIQSASSNNVERAVNIFFDGSWKKPAKASISRGTTTIRQALPVLSTPSTTLTAIPTANTPDTSNEHASVLQRQPAARYIGAFGVGGWATRSGLALLKHGDPVNIERARSQPVAKRGRGGKLFTNNKGDVLTRFTNSAGQEIGRLPHETAEWVSTLIDQKLCQFEGVCVFIPDRVRVNDTIYIQLKCYLRREAFQRGPFMGTVDDNRSMGLFEEKESTEEKNLRLRQVALVKLFHEINLHPTSTNPTTEKHKRDGLLRAAEMAEKYDGVKKEKEKSKSNKDPNDSSSEDDTAELEEDQLDTLYRKAQSFDFSMPEAEPAATFKMNLRKYQKQALFWMLSKEKDKKEARERSMHPLWEAYTWPTKDVDDKDLPSVEGIDHFYVNPYSGDLSVDFPAQEQHCLGGVLADEMGLGKTIEMLSLVHSHKSEPPSGASDGMNSVNDLARVPTSSTGVVPAPYTTLVVAPTSLLSQWESEALKASERGSMRTLLYYGADKNVNLRDLCCEANYAAAPHVIVTSYGVVLSEFRQFAAQSSLAPTAHGGLFSVEFFRVILDEAHMIKNRRSKSARACYEIQAIHRWVLTGTPIVNRLEDLFSLVRFLKVEPWSNFSFWKTFITVPFENKEFVRALNVVQSVLEPLVLRRTKTMKTPEGEPLVPLPKRTVTIEEVELSEQEREIYDCIYTRAKRTYNDNVEAGTLLKSYTTIFAQLLRLRQTCCHPILTRNKDIVADEENAAAVLDATNNLKDDMDLQELINQFTASTENAETEDRSVKFTAHALRQIQTESSGECPICCEEPMIDPAVTACWHSACKKCLDDFVRHQMNKGVQARCFSCRADVDARDIFEVVKHPLSHFATPMEDSAGSDTPPSASQHAPRISLRRINPLSPSAHTSAKIHALINGLSKVPPGTKSVVFSQFTSFLDLIGPQLSKVGITHLRLDGSMPQKARAAVLAQFTKMEEYTDEIIDTEDETPSRTGPSASKSSNSEPTPRVLLISLRAGGVGLNLTVASNVFVMDPWWSFAIEAQAIDRVHRMGQLRDVSVTRFIVKDSIEGRMLRVQERKMNIAGSLGLRVGGDEGEDDKKKDRIEELRLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE26</accession>
    <name>A0A1Q5UE26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_4027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE26"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000067">
        <property type="entry name" value="GATA transcription factor (Ams2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131462" checksum="0F3C78F078AFDAC1" modified="2017-04-12" version="1">MESQDGITVRPMRLKVLYTFDNENKTNCLARWPHVLDLQTAFLDEQTQIGVIELKTCIQAIVSASPELVAQLGKDYTVYAYDYSEYETPLVGQGMLSWVLASASPTPDAPAHQSKTMVTGRVCKNPLGLFSKGAQETLEVKLRLVPVPTVMQSEYIDSMQRYRELSNVIPHDFDAQSWTNFLRQNPALLEASRKQQQGCVTSPMDQSGIERVHQLLSESTTPRDYSNNYPTNESIRSSSPTHSFGPPSRMSTPAGTRTPTHYQQPLQPKQSFSHSDNIRPSSSASMQDSDFQLHQFGSQSRRDSIHSGYGSGNEDAVEPQQRKRAKLYQAGWPGKSDMNIERQPSSLRVAASTAASVRIHRPTPVNPALSVEQSHEEPVRPPTPISRPGDFQRRVRLPSSLLRESSTHSNSSYTSPYIHSDDVATDQTAHSPEDRYQGLFEPPFNMPSSPPVLESRFPSRSSPNLPPISLDTDSGFMSGGLDDLLDEGAGTPVEDSQRADSRPVTGEKRHRSVRSAVQATPPASAIGLVSEGLNDSMLVSDGLMEPKSNQIPQLPRPNTSSGSRPSSRMSSRPTPKPLAPAPMSQSELEQFRRAIPASDSVAPPPQPCAFYSQNSAGPMSDFSIVETPAPQPEYTRRAPRSGGAAKRAMQVQARLDAAIASGGIPPYCENCGTIETPTWRRAWTKDITGSEEDAKGMMKTRGLLFWEVLERNDNKEVVRFKLYKKGLGVTPEDQGWTQLLLCNPCGLWLHKCKTMRPENRWNRQPPACGTDGKQKRPSRNRKQSGGPLSKPSTRTRSKAVSVRTAQSSPAPTEASSVHNEEGATPNVEDHADEGQDQDQAQDPDEEAEYPNKRRRANSAEPPRSSEKPRWDQEEAIEALRLAIQSSPARNIENRNFPAPDETKLTPKPVRRALFASSQKEGPMKELGASFVNSCSPRRSPRFTKGEKHIQEKENQAPTPQNDLDDLFEGPSLDFDLPVSPTPRRRHTRPGAMHERRHSLPCNSPTANRRKDVGVSTAAARAARLTAERLQRVQEGADHSPRSTRSQTRSPAKQGLPALPDAGLHSEAFAPLDGMILDIFEEVTDETNAFQLENDKFSGNNWADWLPTDYVSPTASDEENNPSDDLINAILSDPAILKESLHNSEFNPFNFDNNVVPDSGFFSSDALQTDPGGLATSQASKPPKERGQAATSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE47</accession>
    <name>A0A1Q5UE47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_4055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE47"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UE47"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="529"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1277" mass="137353" checksum="551F37F8B883CEA0" modified="2017-04-12" version="1">MAFIDIGKDLPTLFKQQAQATPDAIALEDDAITYTYGQLDSEVEALASRLRLFGVSRDSLVGVLLPRSAHYVIACLAALRAGGAFLVLELAYPAGLLADVISDANPAVVITHQSEVEKVKAQCPLIVLDKPAEEINGHAKEAAPLPAEDDLDRLAFVSYSSGTTGKPKGIANPQRAPVLSYNLRFGVQDLQPGDRVACNVFFIWEMLRPLLRGATVVAVPDDASYDPAALVDLLATKRVTETLMTPTLLATVLARYPQIAARLPELRTLWLNGEVVTTDLARKAIKALPNTRLLNCYSACETHEIACGDIREVIDTESLYCPVGAPLDPAHTYILDESGQKVEAGTAGELFIGGDLLAREYLNLPETTAKAFMPDKFDSTPGARMYRTGDLARKLPSGLLEITGRVGSMIKLRGYSVVPAKVESDICQYLAVSHCAVVAHGEGLERQLVAYIVADKEAAGERPAVEINETGHSPAARRILEPYLAHYMIPALWVELGELPTHEVSGKVDLKSLPPPRSASPSGSDQTVDKDPIGINDIAAIWATVLKTSKTLLKPEDNFFDLGGHSLSLADLASRLSRHFGFRVPIPRLADNTTLAGHLETVRAVRDGHTAAVQADLPAVLLADSTLDEDIKPPANASITSIAEANTVLLTGATGFLGAFLLSDLLENTSAKIICLVRFTDPEDDDQAGGVARIRRNLLDLGLWRDTLMERVEILPGNLSRPHFGLSSEAFDELAGRVQVIVHAAATVNLVYPYAALRGANIGGTREILRLASKGGATVQYVSTNGVLPPSGENGWSENTMMDVKDVPTKLLDGYGQTKWVAEQLVLKAGERGLPVKIHRCGTISGHSLTGSANAWDLLTALIVESIRLGYAPEVEGWRAEMTPVDFVSKSIVHLSTQTQADQTVFHLGDPNPVNTRSVFENLKELGYPTQPLSWDEWVALWFEKRGTTKGGDGSFTVDILRSGMPTVEFLRGIVVLDNSLTRPFRAVVERPKVDSLLLETYTRHWFARGWLPRAPSRQNALHRAVQLTKKGPLSGQVAVVTGASSGIGAAVAEALAKQGCSVALGARRKDVLESVKRKVESHGVKCIIVSTDVTNKAQTEALIQAANDELGPVDILVACAGVMYFTMMANVQTDEWERTVDVNCKGILNSLSSTVPGMLSRGKGHIVAISSDAGRKVFPGLGVYSASKFFVEATLQALRLETAGMGLRVTSIQPGNTSTPLLGMSTDAEAVKKYGEPSGAKILEPADVANSIVHALCQPEYVSVNEILVEPRDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG51</accession>
    <name>A0A1Q5UG51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG51"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG51"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="537" mass="57938" checksum="451AC05894054524" modified="2017-04-12" version="1">MATAMAQGAVGNTTFKDKEKPMAVRQSNILAARAVADAIRTSLGPRGMDKMIQTPKGNTIITNDGNTMLRDMSVMHPAARMLVDLSAAQDVEAGDGTTSVVVIAGSLLGAAEKLLSKGIHPTVISESFQRAAAAAVEILHNMSRPINLTDRATLLQAASTSLSSKIVSQHSSLLGPMAVDSVLKVVDPKTAENVDLRNIRIVKKVGGTIEDSEMIDGLVLNQPVIKSSGGPTRIEKARIGLIQFQLSPPKPDMENQIVVNDYRQMDKILKEERQYLLNMVKKIQKTKCNVLLIQKSILRDAVNDLSLHFLSRLKILAIKDIERDEVEFLCKTLGCKPVANVDSFTEDKLGTADLVEEVQASGARYVKVTGIKQQPSAVNNQTVSIVARGANSLILDEAERSLHDALCVIRCLVKKRALIAGGGAPEVEVAHTLAKRARELTGTEAICWKAFADAMEVIPTTLAENAGLNSIKVVTDLRHRHAQGQHNAGVSIRSGGVKDDITEENILQPLLVSTSAIELAAETVKMIMRIDDIALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG53</accession>
    <name>A0A1Q5UG53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclear localization sequence-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG53"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG53"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="236"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="489" mass="51590" checksum="1806C3D58EECE5AB" modified="2017-04-12" version="1">MSKTKVSSKVDKKATKALSKVKDAGVTKATASPAAKSKVAAKEAKASRKNKKKEPTPSSSESESDSDEDMKDASSSSESESEDEKPVKKESKKVEKKEESSSEESSSESESEDEKPAPKKAAKKEESSSESESESEDEKPAPKKAEKAAKKEESSDSSDSSDSESESEDEAPAKAEKAKKESSSDSESESGSDSSDSSDSESEAEEKPSKKRKAEEEPVAAAKKSKTEDAPEGASANLFVGNLSWNVDEEWLQREFAEFGELTGCRIVTDRDSGRSRGFGYVEYANAADAAKAFEAKKGAEIDGRTINLDYATGRQNNQQQGERAQTRAKSFGDSTSPESDTLFVGNLPFSASEDALRDVFGEQGTILGIRLPTNPDDGRPKGFGYVQFSSVDEARAAHSALQGVDVEGRPLRLDFSTPRPPREGGGGFGGRGGGRGGGRGSFGGRGSFGGRGGGRGGRGGFGGRGDGQGGYNKAKGSIPEFKGTKVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGK1</accession>
    <name>A0A1Q5UGK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cocaine esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGK1"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="53"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="327"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="47296" checksum="231AA7A37C0F1F73" modified="2017-04-12" version="1">MEVTGKNPCGVKPFYWKKGIPLKETSRPPLIPNKEETADGMNITWDVPVTMRDGVKVYVDVFRPEGVTDKLPIIFTFSPYGKHGPKTFDIFPGADVPKGWISKYTVWESVDPVVWTKKGYAVINGDSRGSWGSEGDLEIFSQQESRDGHDVIEWAGTLPWSNGKVGMIGVSYLSIVQWGIAAQNPPHLAAFVPWEGFTDFYRDYTHHGGIPETKFLHFTQWSCRAGVNLVEDLIENNKAHPLLDDYHRSKCVSDLAKITAPAYVVADWGDHGMHTRGTLNGFVGISSKDKWLEVHGQKKWRYFFEPESVKRQEAFFTKFLKGQKSEVDLWPRVRLEIRDRAWKAEFRPEQEWPLARTQYTRKYLDLNEGTLVDQNPSAISEVAYNSTVTDDCLRFQHRFSKETELTGNMRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH66</accession>
    <name>A0A1Q5UH66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH66"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="493"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1140" mass="125566" checksum="29C4C848A359B86F" modified="2017-04-12" version="1">MASTSDPESQKPEPQLDSPHDSESDSEISSKPQPPTGYNLPLWRKCLILFVVSWMTLAVTFSSTSLLPATPEIASDFSTTTEVLNVINAGVLIAMGFSSFIWGPITDLFGRRSAYNAAIMVLCACSAGTAVAINLHMFIAMRLLCGFTGTFFMVAGQTIIADIFEPVVRGTAVGFMMVGSVSGPAIGPCVGGVIVTFAQWRIIYWLQFGMTALGLVLSLLFVPNIQKKQQPLPARGPVNLSLVLRMFNPLRIFGPFIYPNVFLCHFTCGLLATFQYAILTSARSIFNPRFHLTTPLVSGLFYLSPGIGFLIGSVMGGKLSDRAVKRWIKKRNGVRLPQDRLNSGLITLFAVLPASTLIYAWTLQEEVGGMAVPIISAFTAGIGLLGTFNGLNTYSAEVMPHIRSEVISGKYVVQYIFAAAATAAVEPLINSIGVGWTFTICVAFAIIGGFCVLAITQWGIDMQRWVEEKLGIDAKPAYLDQLLAENRRLKEQSVTSADATEASGPPHAERAPSRPADATDAPDATSNQNPIIGDRAWFHRYDPSSPPIYIGEAACSAFATRFRRFLTGNNATAHITRTQWEREEVIAAAANEANAQWPSLHHARLLVRIAINQIGHLYHLMMRKTTLEKLEEIYQTGNFECVSNKCKFFALFAFGQAYSVRSDPTTGSRVPGTAYFARAMSLVQVLPERTSITHLETLLLLSLFSYYLNRRHSAYVLIGNAMRMGLTIGLNHNIPESQLIDPVERQHRIEIWWTIYIFDRMWGSKMGLPMQILDEDIHVDMPTTISPSWRHEEELSDTDYMTANIKLAKIAGETITRLYSRRKYQETFLQRVQKLLKALKNWVDTLPEGLRLNMEDLESSKKPVVSLHMAFNQCVILTTRPTLLHLLITLRKNNGSRPLGENIRDSVSQPVLTLSEACIHAARHSHSMILTRWINGTCPSFGYFHAHYLFSSALILAMSSFVPIGNPNDMSGFDSALDVLRSMSENGNLAAAEFYHNLEQVKVCLDAYRGASRPQKTDSGPEINVDVTHSPTAAALRPMSGLASTLAPSSSAHLPGILSTASTAHVLPPDGDLLAGQPSHGPDAYILPARDTINGYTTEMAFLEPTMQDFLAQSDIDLGLLHPVDTFLSEVENLYTCHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI78</accession>
    <name>A0A1Q5UI78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI78"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI78"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48584" checksum="F10F57933C97C386" modified="2017-04-12" version="1">MACSILDPKISFFPKADGTILRSKHVAPPPLSRPQTVGPILDRDNVDRPIQAWSSSVKSTFYPNTEANEPSVVPEKPPDFAERYVRAFLAEHERLRLSVLWYYTRDVLLEDEFLAGLQEKAQLAQESTGWEFAVIGILDVDVYVRLATVGLELGILPRGETLCAHTVTQPPGDVFLLPSLMEDWRFQQCPYLESGGLYAYAGVPLRLKTESGHTVGLGSLCVASSKSEEPLTKAQHQALVRLADWVVSDLVQCTRARRQRERHRMSELLAKAQKETNQAVAMEPVLEILKTIYPDAIIRLQPSRATHVEFEGCDPIPVSELRDGLWEDVQYLDDFITNSNHLPTPTNKPVRIVASPCESISGSSLLIVATKDFHLVFDDADAWFIQACADLISQMWRQSLLAEAMIAKEKFLRAFSHHYELQSTASWVPWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UI90</accession>
    <name>A0A1Q5UI90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000245">
        <property type="protein sequence ID" value="OKP12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UI90"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UI90"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="74690" checksum="EA49B1FD974B273A" modified="2017-04-12" version="1">MAYYDDRRHYAPRDRGRPAAGYAADYYDDHPRGFNARNDREVYSPRGGEGSVEEIQRDYPPGSDYVYERGYDSRRSRRPVYENVRRASSVGGYDPYYDNGYYRSRTRRTRQSDDHRKWSLFLTEALASCATHFILGILNPVAGPRRSRYSSASSSSPSPSRHRRRKSFGETALGALGLGSVASRQSDRTDRTDRGRARSSSRRRGRDYSSSRSRSRSRDRDRNHRQRSEQRLAQAARAALTAGAVEAFKSRKDPGDWTGAKGKRILTAAVTAAGADGLIDKDPKKHSGRHVVESTLAGLAASHFVRGGSSSKGRDGRGRSGSGLKDLAATGALAAAGKEIYDRMSRSRSRPRGRDDRDRDSDDDRRGSKKRSKSVSEYITKGMAALGFGEEASDRGRHDRNRDRDDESLNYRYDPRRERRHHRDRDSRYDSYSDSDTETDYRSRNHRHGRGSRDVGRNRSLNGNKAPPIAPTSAPRGEMKGLGSSNRGSHSSSESDSDLGDSSDEKEKRKKLKRDMLLTSGLATVATIHAAHGVYGGIQKRKERMQQVKDGEITQEEARKRRIKANTIDAFSVGLAALGIKGAYGEWKEVNEKRKETKHFRDECAQRAIKREMRRCRSQGSAPNSRRRWPDEIEYPDSHHGHGSGFSYNDGNPYGATSEAPAISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIY9</accession>
    <name>A0A1Q5UIY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIY9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UIY9"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="38655" checksum="70AA32AA03949C07" modified="2017-04-12" version="1">MSEGLPEMQYRFLGRTGLKVSVISLGSWLTYGGHVGNETAFDCLKAAYDAGVNFFDTAETYSGGQSEVVLGEAIKKFGWKQNDLVISTKLYWGKANSANPDKPLNNVGLSRKHIIEGMTLSLQRLDLPYVDIVYAHRPDRDTPMEEIVRGFNYLINTGKAFYWGTSEWSASEIADAWRIADKLGLVGPVVEQPQYNLLARDRVEKEYRWLYEAHGLGLTVFSPLKGGVLTGKYNDTTAPPAGSRLAESEDGYIKGLRKTVGDDSWTKQLKQVAALKPIAEELGISTAQLSLAWILRNPNISSMITGASRVEQVYENLRALAVADKLTDEVVEKIEAAIGNKPAEEIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ69</accession>
    <name>A0A1Q5UJ69_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ69"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ69"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="203" mass="24097" checksum="8223F0B3B4F6D614" modified="2017-04-12" version="1">MGALKYVEEIQKKKQSDVIRFLLRVRCWELRQLNAIHRASRPSRPDKARRLGYKAKQGYVVYRIRVRRGGRKRPAPKGATYGKPTNQGINQLKYQRALRATAEERVGRRCANLRVLNSYWINQDSTYKYFEVICVDPQHKAIRRDARINWICNPVHKHREARGLTATGKKSRGINKGHRYNNTKAGRRHTWKLHNTQSYWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJR7</accession>
    <name>A0A1Q5UJR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJR7"/>
    <dbReference type="OrthoDB" id="4207369at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="697" mass="74869" checksum="C073CD3BC9DC47F9" modified="2017-04-12" version="1">MGTDPALPQAQSCDTSEAPADDNSFRFTPIKAIRAIPRLWERKPATPFKAGLKRKLWKRFQGSFSNMQSLESSTAKDHDALQTAINTSKDSSYVRGVKRLCVGPGESADKIDVELSQPGRPFLETKWESEVSRKRRKLPDAPFDVYDERLGGTLDCTNDKRSDAKDIDYDLDADGDLAMATASPILFKSLRSPPKTTIFQDTMPTEEPNLTASKVEPTEQFEMGSTNQLQRAMLDGAAPEGKGDVAATPTKTVRNLTQAQEGTLVRSALRSSLDGEDAMLLNDFLSKAMAKRAAKAALVNSQESDSPDQSSSPDESPDSECATPRSRRALEDRDANANSPSPVKAQISPSKGDFIPGDESHEEAVSKDTQDEEETAPESPANRRSARVKAPPANARPVRNTISLRRAKGNEFVFMQRTEAQELALATRRNTRNNRGSSMMPRYALQAMAQEDSTATDSDIQGQSRADRKTSGSRKATSKSRKNVTWNEERMVEYEGDISDPPSSETDADANLERDESSKANADGSSSRARSAAKRSEKKSSSSIRSSRSQAPENAEAESGPTAPAPAATPVSKTSKSRRVRRLGDSAMTSGTPVKTGSGRVSKPPTTSATSVAPAAAAAAGPSTPTKPRRKLVPKSPSSSLLSVPAAKASSSTGGEQHFVSGIPTRSTAGSEGTKRKSMVEANAGCTPMPRRVRARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK15</accession>
    <name>A0A1Q5UK15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_1558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK15"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK15"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13580" checksum="AC57461476641A14" modified="2017-04-12" version="1">MSIPNEALQKILQEIETRAIASQQQIGVTKAQITTKQRDIRMLQLTSKELAELPSETPVYEGVGKMFVNVPIGTVNKRLTRESAEASSEINNLEKKLHYHETTFKNSRENLEQILSSGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK95</accession>
    <name>A0A1Q5UK95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000171">
        <property type="protein sequence ID" value="OKP12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK95"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="59" mass="6718" checksum="898846EAE00E7D10" modified="2017-04-12" version="1">MAQQTAVTRWPKAVEGTVDNVDETAASSDKDKRAEWATMRIALQEIMHEIERNEPFKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL59</accession>
    <name>A0A1Q5UL59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL59"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL59"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="255" mass="28358" checksum="77CE206CAA5D7B64" modified="2017-04-12" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGILAKDGIVLAAERKVTSKLLEQDTSAEKLYTINDNMICAVAGMNADANILINYARQNAQRYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGWDHLRQFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDSTLQEACAMAVKVLSKTMDSTKLSSEKIEFATVGKTKDGKIYHHLWSADEIDALLREQGLAKVDDEPEAGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULI5</accession>
    <name>A0A1Q5ULI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULI5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULI5"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000104">
        <property type="entry name" value="Thioesterase family protein (AFU_orthologue AFUA_2G16350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="34"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="181" mass="20028" checksum="6E325B1630E81B15" modified="2017-04-12" version="1">MAASDIQAKKSRKRSDYGYHQVHQTRWFDNDMYAHLNNTVYTALFDTIANAYLIEHCGRNPFSVNNPTPTPSIPSSSTGQESTLNIGDDQIGLIVSTHCDFFASVAFPDILEVGLRVAKLGSSSVTWEIGVFRKGEEDVKMVGSYTHVFVLRETMRVGKGGMVKQVREGLEKLLNSPGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULS6</accession>
    <name>A0A1Q5ULS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULS6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULS6"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="405" mass="43368" checksum="A2ECCAC96494E353" modified="2017-04-12" version="1">MSATSDCREIVVVGGGIIGCCTAYFLTRHLSYDPAHHKVTLLEASDIAGGASGKAGGLLAQWAYPSNIVDLSFKLHAQLAKEHDGKNRWGYRETNCGQLVVKGRAMSEKSQKKEEGESLQKRSTAAVSKLKSAKIPEDLDWIEPDLLRAYESMSGPGETAQVHPYLFTTSMAKLAEEKGAEIILGQVTDISRPGDIVESVTYTDKASGESRTIPATDVIVAAGPWTRSVLPEAPIAAMRAHSVVIEPARPVSAYALFTNIEIPANFNPAKKSRPTVAAPEIYTRPDDTVYACGDGDKTVPLPSTSADVEVDPERCQEIIDQVGSISDALRDGKIRTRQACYLPNCENGGGPLIGLTHTKGLYLAAGHTCWGIQNGPGTGKLMSEFVFDGQAKSAKIGSLDPRDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMD8</accession>
    <name>A0A1Q5UMD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMD8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMD8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="479" mass="52706" checksum="D6B5CD6809027E9F" modified="2017-04-12" version="1">MDVETLKDSQAVHLEVSPKATLQEVRFEGLTLEEETVLEKKLVRKIDLHLVCSLCLLFIFNILDRSNIANARLGGMQTDLGLTDTQYQTAVAIMFVGYLTGQVPSNIILTRVRPSRYIPIAIFIWGSISMCAAATQNFAGIIVVRVLLGFAESPFFAGALSWYKPQEIAPRVAVMYCGNTIANGFGGMLAAGILSGLDGASGLAGWRWLFIIEGAGTIVAGFLAVWLLPDFPGSGKHSWLSDQEQRFAEWRLAQGANSEFDENGSVKEGLIDAFTDPKAWVLVAIQICQLTSQTWTYFFPSIVKTLGFNNIVTLLITAPVYVFGFITSLGNSFIATYTDKRAILIVWPLMVDIIGNVLVICTHSTAPRYVGMFLMCAGSYSAFNVVQAWIASTVPRTRTKRAIVYALVNLCGNSANIYGSYFFPSKDAPQYRLGGIILSSFAAGGIVLALSLGFWLRQLNIQATREEERDGQPRYKYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMK5</accession>
    <name>A0A1Q5UMK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000127">
        <property type="protein sequence ID" value="OKP13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF8">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012231466" description="ASST-domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71513" checksum="1DAB9144C7E36494" modified="2017-04-12" version="1">MLWLGLLLLCLQNVVAWHSDDDLMSFVTLPDVRAVKFNITYQDRSRVAPGYWFVSPYLHISPDEPTSLYEQYQVGPHIYDQDGQLIWTGSPMFDNRNVFDFKVIHSIGNEPHISLILQYNNDGSERGFGMILDKNYEVFKKVPLRQDLGAFDIHEFNVLKDGKTALVTVYLNEEISLAEFGRPEEQTWLETGGFAEIDLNTAEVNYEWRSYNQIPLAETVHYSQYSDVEGPPGWDYVHINSVDKNDNGDYLISMRFTNTLYLISGVDGHIVWRLNGQHSGDFDQDFIFSKQHDAKFLESSGTRHVISFLNNASDEEFAEEQVSSALIIEVESGTVPMTARVLRRYNRPDGDLTRLRGNSQVLPNQNMFVCWSQGGYISEFTPEGEPLMSARFTSPRYSNYRAYKFEFTGRPHTPPDVVSSVIGTDESNLVTTFWVSWNGATDIAYWNFYAQASQFDKPVFVGNAFKSDFETMFIAKGYLDWVSVEAVDRDGNAFGISKVQRTSFPNWQTSGWNGYSSSPRPNNPATIYRQDSSITPDDWTSDEDLLPTADDTADAQLRKATLTLMNTYETIRSIGGLFALILLLAVMCGIMASYLLIRGWRVRLYQRVPMEEGLPEEEAHLRSDRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UML3</accession>
    <name>A0A1Q5UML3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-saccharopine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UML3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UML3"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="436" mass="47799" checksum="DFA3D3D8EDEE2BF6" modified="2017-04-12" version="1">MGVSKSDAILIVGGGAFGLSTAYHLAQEGYTNVSVFERDDHIPPRYSAANDLNKIVRAEYEDPFYTDLTIKAIAAWKTPLFAPHFHQTGFLHCVSGDAPQKAIDTLNRFRASAERNALIKPHVRSLDGEEDIRQTCWQLDGPLPGWKGYFNNFDGYAHSGNALAGIYRAAQASGVRFFLGEQGAVDELVYVSTVNGRKCAGIRTKNGRFHPSSLVIVAAGAGAGRLVPQIGQQVVAKSWSVAHVQLTDDETSGLRGIPVTYARDLGFFFEPDPKTNLLKLCPMGGGYINTDPKTGVSHSPKSLKESAFVPEEDEKQMRKLLAQTLPSLADRPLVKKSLCWFADTNDSEFIIDYVPNLDSSLMLLSGDSGHLFKMFPIAGTWVTDLLESPNNKQTLARWRWKQPDPKAGKDWGGDVSWRLGDSKELSAIMPAKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMN8</accession>
    <name>A0A1Q5UMN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000126">
        <property type="protein sequence ID" value="OKP13721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMN8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMN8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="57480" checksum="F623744A73123E4B" modified="2017-04-12" version="1">MQVNDLRWDDSYKYIWYSDNGPWSTRFTAWYVAGLLFRNKGQDVSNAKAAIENILTCQMTESYESAWYGTFKRSPDEPYPTPDSELYPPEIYDTYDPNWREFIGTQLVQIVEEFSDLLGESLVARIEDSLEIAAVGSMRRNGSYPEGDNLTPAYSNPALMRAWCVSWIGKRRNNETFIKYSNDQADTILELFQSTGSNVLSEYNAPTYYGMDTWALAGAIKYAPQDSAIARNAKVMLKDLWADIAAHYNPYLSVMSGPYDRAYTRDMVTNSAVVDYFWWGLFGYGTGPVPNKLEADLLYDVTQGSALALVVDVVAAHISKNDSAWLQSQGNWSGERMITKKVPDTLGADSEVRVVTSWISSSLMIGAEQVNETINRGQQYVPAIVQWAGDKDHKPHPYMSFFSLYPTASTIDAIAGPNSLEISYPNTTQDGTNIFTFALAQIPPSWTLIKKKVVNGLEDLPCLDVTVSAEGLEKQPVIYGATLEDNRIYNISYVVPSGFVGTPKVSFKFKYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN41</accession>
    <name>A0A1Q5UN41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN41"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN41"/>
    <dbReference type="OrthoDB" id="5272500at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="33118" checksum="95F166E78E9D1263" modified="2017-04-12" version="1">MSSYEATSPFRVSTHDLIQLERNEVFRAMREQLRRQDCGMEGPSFCATHRHSCSSAEQESFRLHRDIIHTLLVPLFLINHQAERIAARALPSKKGAEPERAFRGEARSAFAWLSCILTEEHDWYLTARCPGCIVLHVLHSEPTIRFVTVAALLAGPRSGFDCWLAALETAVREDPFWGDAFWPEIEDRAARLTDGVQQLVRQCHELRTALDSPTLATPTLAKTSTTVCERSASTCTIPLKPSSFARKQVRLSREEQRYRSSLVWNSWNCSREMDQPLGGSTPTQSRRRSMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN94</accession>
    <name>A0A1Q5UN94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000121">
        <property type="protein sequence ID" value="OKP13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN94"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="250" mass="27111" checksum="A01321C3DDED8E57" modified="2017-04-12" version="1">MGLLLEIACFNEESAVNAAQGGADRIELCQDYQSGGLSPHPSVLQAVKSRVSIPVYVMIRPHSRDFCYDKDEFETMKATLQLMNNSGADGFVFGILHETPYQGGTDRNLWVDIARNKKLVQVAGGKPCTFHRAFDCIPESNWDTALEDIRECGFAAVLTSGGPSSTNAVDCMDGLADLVNRQSFNPESHPQAGRRALEVIVGGGVRSTNIGVLREKTLATNFHSSGLSSSSEIASITAVQDLKRALFYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNG6</accession>
    <name>A0A1Q5UNG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arylamine N-acetyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNG6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNG6"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2140.20:FF:000003">
        <property type="entry name" value="Arylamine N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="318" mass="35542" checksum="D1CEAA1B1E6C4780" modified="2017-04-12" version="1">MGLDQPTYTDIQVEAYLRRLAYKPAATEGTGLVEHARQRVQSDALGTLTELQRHHLAAIPWGNSGLHYSQHHTISLHPDSLYEKIVERRLDGYCMESTGIFFIVLRSLGYCVYATGGRVSHAAATGVDNGLWLAFGHMVLIVIIDEARYMVDVGFGNNCATAPLLLQEGATATCIAPSEMRLIKDTLVEVTDKSQKVWIYQTRNNPESPWIPNICFSEVEFLPQDFDVMNFSVSKKPTSWFVQTFVCVRMILDPTGKEIIGQCIMSGGEVKQRIGGQTEILQVLQTEEDRVKALAKYFDMHLRTGEVEGIRGLSSQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP23</accession>
    <name>A0A1Q5UP23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatogenesis-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_71</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP23"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP23"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="711" mass="78998" checksum="1465AADC0571D489" modified="2017-04-12" version="1">MEKESFMSPEVATILNESFVPIKVDREERPDIDDIYMNYVQATTGSGGWPLNVFLTPELEPVFGGTYWPGPSSSTSQGPGTTGFVEILEKLSDVWQTQQQRCLESAKDITKQLREFAEEGTHSQPTGREDDEDLDIELLEEAYQHFVSRYDSINGGFGRAPKFPTPSNLSFLLRLGAYPKQIRDIVGQEECEKATTMAVTTLVNMARGGIRDHIGHGFSRYSVTADWSLPHFEKMLYDQAQLLDVYVDAFRFTHDPELLGAVYDLAAYLTTTPLQSPTGGFHSSEDADSYPSSNDTEKREGAFYVWSLKELTQVLGPRDGPVCARHWGVLPDGNVAAEHDPHDEFMNQNVLSIQATPSKLAKEFGLSEEEVVKIIKGGKQKLRDHREKTRGWPDLDDKIIVAWNGLAIGALAKCSVLFGEIESSKALQCREAASRAISFIKDHLFDKATGKLWRIWRDGSRGDTPGFADDYAYLTSGLLDMYEATFDDSYLQFAERLQKYLNEYFLSKTDVTSSGYYNTSSEMTPGMPGPLFRLKTGTESATPSVNAVIARNLLRLAALVEEDSYRTLARQTCNSFAVEIMQHPFLFVGLLDVIVGLQIGTRTVTGVFSTAEISPSTASRGESLLSRNDEPMVARDLIVQRVRAEAGAGLCPTLAVASLVDIRPSHLKDFVGNQSFWLKSRNSLFKDLKAGDPAKNQLLICEAGRCRIVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP28</accession>
    <name>A0A1Q5UP28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_90</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000105">
        <property type="protein sequence ID" value="OKP14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP28"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP28"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="242"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKP14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="677" mass="75922" checksum="0A6CDF8BE2A16EB8" modified="2017-04-12" version="1">MAPPHPFDPLTLGEIAKAAVIVRKELDGKDPNFRVITLQEPPKQEMISFLEGELRGQSHKRPARAARVQVTIRGNSKPNEMVELTIDLTTGSVIKKEHLVGKHPYIDSAYMQAAEKACRADPRIETEIQNLKLPKGAQVVVEPWAYATDGMNNVSERTTMCWFYLRLLDHADANYYAYPLDLCAEVSEQLQVTKIYHLPSSEDERIREDARLYDHSKAHSPELSEYHPDLRPPPRTTTKPYQVVQPEGPSFQVDGNLLSWEKWTMRVGFNYREGLTLHDIRYDGRSLFYRLSLSEMFVPYGDPRTPYPRKGAFDLGNDGAGINANNLRLGCDCLGTIKYFDGWHNTASGEPLKLPNVVCCHEQDDGILWKHTNHRTQNAVVTRSRILVLQTIITVSNYEYIFAFHFGQDASIHYEVRATGILSTCPINNGDKVGYGTVVAPGVLAPYHQHLFSLRIDPAIDGYANSLQVEESHPMPINDPNVHNPLGVGYTTKSQIITEEGGHDLDFVSNRTFKIINEKQINPITGTPVGFKLLPCYSQMLLAHPQSYHARRSEFGSHAVWVTRYQDDELFPSGRHTMQSLGGEGISSVIEQRKSDPAASSVRNEDIVIWHTFGSTHNPRIEDWPVMPSEKMVVGLKPVNFFTGNPGLDVAVSTQEKNESVLVDDGAGCKAGICPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPB6</accession>
    <name>A0A1Q5UPB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_14092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPB6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPB6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22113" checksum="BB25B576605AD0B3" modified="2017-04-12" version="1">MANADHIIQGVPSGTGNPCNDGWFYKFDPRLQSKTEAPSWLKSFMIGGVYDEGVIFTTNVMNDTYETFRQTLLASIQDEVYVNRTLHEFDSTQNIPGPELVEKGCTVSGEAVFKIPNYLTANVNERLRGEKAIFKYHFDQRSRLENLLNGRAYHFDVVYLFGNLDNKLYARERAMGHDIASAWIKFAWGQEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPR3</accession>
    <name>A0A1Q5UPR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_14068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UPR3"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="793"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="878"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="968"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1330" mass="148243" checksum="92F9720A6B77BCE3" modified="2017-04-12" version="1">MSNPPPVPEDTLPDPLVTPATPAHHDCSKNAERARSNPRHHSSQDQHLSQGAQQAQSPSRAESPTTTHQWSQPVSNLALKRAPTIPLENFPRPDTTYSPQLSERDSIFATHYLPSDSAATTPQLPPEQPSDNERQVNLIPGLDDVSGSLAPLSKVSSHRSHVDPSHMEVDVRRHIPLRSSSLFSSADVSRLSRLRSSISSTDQVKGKGVQTGVQSRLPGPLDESGTKTGGSHSSVTERSLLPSFLDDVSRSPQSLTPPAPGQDWPVSPEAAPHTSLADSSRGIALERSSSRGRRGRVDSSIEADLSNVEPASNVRSRKSSHYLGLFKENTTSPDRKRREDRAQQHDEKSEQPDRTMEIEHPTLRLVAEEEGLLRKSISLPSLADGTTFDPPQTAESTLQTEEDEPYKRRPPTLPRTLLEEIRNFHLTPGGGRGSSFSKSIPTQYAERGRDYFQKDPHVDRFSESLSSLEEEERRASDRFEDDEEENEQISSALYFPHERVAVSEGVEGAEPLVSDPHGAQPVQLSAAEKGHELMLVPKEQRSVSSEQEAGHVDISFRSKTESKTLYGELGDIRHPAETVPEKPLTSISERTYESTCESEAPSADESGLSVHDESSLTDDAELTPTATPTQRSRFPPKPKRKTPAPLGAVELKPYRHQVGGHTTVFRFSRRAVCKQLNNRENEFYERIERRHPDMLVFLPRYIGVLNVTFSKTSKRSKNRPDHAAHDASEANHANGTSLSNAHALEAPEPQRIVSQKQVTGVIPKVILENNRHIIPADLFSRPHRHRLIDDTMMGRPRSADGLGKLSTESDPSSLRKRNKIWGATTVNRKLQEQVLREVFSPPAIHQHRRHARGHLQLPRASSDIPHRRGNLSEDHTASSRPSPLTKMDATQTPALTITSHSAEGQTLSSSASTALEENRNRLEKVKTEVQPNRSSSLSRGQQVRRRHSGGGLQRRGSLNSHNTGDLMFFDDEGYGGDREDEIFSMEGDAPVPPPESLALKASSSPSSESTSVSEQYSSDPSSRRPLETPRSTVKDDDEDVGTHLPSNPKEAQLRKDERVQFFLLLEDLTAGMNKPCVLDLKMGTRQYGIEATEKKKKSQRRKCQSTTSQQLGVRLCGMQAWNVKKQEYIFEDKYFGRDLKSGREFQDALTRFLFDGVSYTSVAKKIPIILEKLSLLEHMIRKLDRYRLYASSLLILYDGEQATPQTPSQAGEPRPPPPRRRASEDGHNNFDVQLKIVDFANCVTGEDELPPDTPCPPHHPQDIDRGYLRGLRTLRMYFQRIMREITQDEFVERGEGEAIALGSQPAVRESSSDQFWDENVMETDAGEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPR7</accession>
    <name>A0A1Q5UPR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_14075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000098">
        <property type="protein sequence ID" value="OKP14463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPR7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="73"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP14463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="236" mass="25454" checksum="61BDD9A5562D0A8B" modified="2017-04-12" version="1">MIWPPVLRAISSHIGFRNALRISGCLVIPLAGFTLRWEPNFNTKVRGQTAGISRKTGWVNVPLVNWRVAQSKTFVLQALGCFLQSSGYATPPFFYAAFARSLGYSESMVDNFITISNAANFVSHIVIGYMADKYGRLNVLFLTTSLSSIAVFAVWLPATYANTAISGTAADVLLILFAILYGCFGSAYISLFPASLIELFGVQYFTSVNGALYLIRGVGALLGTPLTGLLLPGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ40</accession>
    <name>A0A1Q5UQ40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ40"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="5812" checksum="3AA5E76D19110331" modified="2017-04-12" version="1">MGRGWRSESENVEKSAAAGPLGVTASLVRLGHPITFRGARQLEMRLTPVVYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ49</accession>
    <name>A0A1Q5UQ49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_13941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ49"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ49"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000431">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="350" mass="38934" checksum="6B5669BBB3B3546F" modified="2017-04-12" version="1">MASRVTEIASRLYDACLERFEADHLFYQQDLLALDVIPKGEIDLLLKCAQSLVDQKLFRLLQGSNNRLAWKIISRDDAEKLQSLSPDESLVYNVIHSSGRSGVWVRNIQSRTNLHKSILDRCVKSLESKNYIKSVHNVKYPTRKMYMLAGLAPSEDITGGAWFTDGVLDSTFINTLAGLIEFKVSTQSWYEVPTADRGRSKRIKTATGMAEVKSESEKTFLPYPANYSGYPTIEWITTEVNKSGVTPVRLGEDSVIQLVQMLCFDKKLVSLNNGINYKAVKNPVVVKAGFNRKPAAEEEAGSPILGLGKNGMTEAPCGSCPNIRLCSPGAAISPETCEYFDPWYEKVLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ95</accession>
    <name>A0A1Q5UQ95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ95"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ95"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="122" mass="13955" checksum="ED31E23243E6991F" modified="2017-04-12" version="1">MDAQKKLQALSDEFQQLQTELEGLVDARQKLESQQQENQGVQSEFAQLDDDSNIYKLVGPVLLKQDKTEAVMAVSGRLEFIEKEIKRIEKEIEEKQETSEKKRTEIVQFQSQVQQQAGQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URJ8</accession>
    <name>A0A1Q5URJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein ELYS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URJ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URJ8"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="313" mass="36006" checksum="2E075EE5FD677233" modified="2017-04-12" version="1">MAQWEDFNHIFNFNKKYSYDAKVVDQIISNRKALENQLFADRLLGLAGITGVTKVYPPKSNADLRSLIEHIVSSELDIHHKQALVYYILKDCRSAPEAAPHFAQDCHLPEKYRLFIEGLWNLDRLEFRRAIEFLAEPSLIPTFPDEILYVLTLSQLPKHDDSLAIAYYLTAAPPLATEKVQRAFYETLCRSNVTEAFYFTRKYDESQRRTYFEQLVEFVHKTPAGQTRSKRAMELVGLPLGEDEEEWFEETLLHGSARSFPGAKDTVMMRRLAIGQMSGLGTELESLGGKKVDGLNWDTLRESMRQTQNVYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URL6</accession>
    <name>A0A1Q5URL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URL6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP15089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="691" mass="75137" checksum="A9840D43D07DBF2B" modified="2017-04-12" version="1">MADFPSLAPVPSPAVRRTIPSNDWDACLDAWMTLLGIRLNVPDQKLKDVATEDLSVVSFLDSFYQHAAAGDSGLQSGPRAQQLRKLCFLTTRRYLLSLSNPPEGLLSWQLLSNLCCCYPSSTALKASLSAAWDMHHEKISSSIEKAKSLVIKQLSMAGKTAALGVLADIRRLTILTSVLPNCGQILMAGSDYLDTLYEAYQAKDTREELRKILVANVYVGLVSLLKETAINLSLLLDQIFSLKASAGVGTPGMKNEATLLSDLVCSTDLLQRLEKHLTIHPQKRGQDLLASLRLYQMETSPFHHRYQRRKKVDKGKGPSTGPVIPDELHAHKMSLVSQVQDLFPDLGSAFVVRLLDTYGDNPETVIAHLLDDSLLPELQSLDRTEQLPPAAEPSHSHLEPRSTPPFIPAEPVPSRRNVFDDDVDIAELSLSGDAEGKLRFGRANPELTADEVLADRSKHAINKAAILSALATFDSDDDERDDTYDVADVGGTVDSATTGTDAEADAIARTQRAAAEQIDLTLLRAYKLNPAIFARDSTTRRSQPRTLLKQETNMTDEAIEGWAVILLRDPKRLSKLENKLADDLGGAGSGALNQPELAPTSYRKPHPTEEDSDEDGGSSGYARGRGGRGTGGRGGGRGRGRGGRPPQSGEQGQQNSAVAHQRKEQNKASRANHNRRQQRAKKIARGGGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URM2</accession>
    <name>A0A1Q5URM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_2175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000023">
        <property type="protein sequence ID" value="OKP15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5URM2"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF119">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="75"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1044"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1588" mass="178265" checksum="8AB416ED0103D99A" modified="2017-04-12" version="1">MSVSSLNDDWVKCRSPRELQSDMLTWTTSISRSRVSTVDGLGFSENIDVESMNSLENLLHTVQKLKLKHFRAEDLEEIRAVGNGETFAVSECKYEGTVVAIKRIRLSEEGKGLERSHFRRRLQSVLREILIMCHPPLIHHPNIIDILGYGWGVERQRPSPFISVAFASKGTLREYMKEKVHPIRTKLILMGDVGAGLMALHKCGIVHGDLKLDNIVVFSSLDRPCMSIAKVSDFGHSIIVGSASGKKMQYFGTTLYNAPEVAEQKDQPIPIEQLHKCDIWAFGLCAWEILADGQLYFQRSWRRNPLYERSTSLSTSLTSPTGSEAHDEFSIDEDDQHVFGYFDLSHLKALAIEFVYNMKIPGIGFEKGFLRPLMDRTLQRDPAQRISDLSRLPIIVSWHKTPGGHSLQSKLATYAMSGDVRYSIFSRESGPYIIWEQQQQLLQDFEIVAQGSNSVKDDGSIAFQTMLCYINAFGTSQDLDKATVFLRIAEDTGHLVARILGPRILNGFNRDSTEVQPYSECLAWGLHITQKPELITSLVVHDGESVTKFTNYSGFREAFSEERLESSKNDKDGALGAFVTLNESTLQHSLLDIALQQGDVEFVERLLPLVDLSIEASKLDPYLVSAASRGHDSIVISILKAGAKISLMNTASSLLHWLFCLSETTLRAIQSFLKNQSRNVNFKSALNHATTESISLHPQWPFQVHGTPLAVAIASGSMPVVMFLLDLGADPLAPAFEIDDDNIGRSLTAIHLAVKYHRPDIIQLLWKAAFGETKPATGTHGLLATALGSFPIACSLSLLTNAERLAIHGCMYKQRLRETIKLLSLDFLLQNSPEGRNSITQAIDLEDVDTVELLLEQSPSLASRRLFQPDNNTMFTYPFHFAVQIASCRDTRESEQIVESILKLDPAAINRPDSAAIKPLHIAAMGTSNRMTKFLLDRHASCHELDGRGRTPLHFCRALVNAKTLMLGGVNINHRDDFLFSPVHAAASQGADEVLKALIDAGADLSLANNEIGTPLHCAVQRKSRATIELLLGAGVDVKARNRRGRTPLHLAMDIGRSDLVSLLFQAGADPFVEDKQGYSPFSMSLVWENPSIFNMFKLPNHFVVERLHINALIFAAAKGETAVFRQYLDRLPDPSRNLDCVTLPKLYITAINVAAGACRVDLVEMLLGHGFSVDTLDEKKNTPLLRACQAGRTEVEFFSYNRTHMCETLIQHGADTLARNDRGLTPFLVAQTHADYPLMTLLLSQHQGDLSTRISRVLKSIKEPEIDDEYRRSSRALIGGEIIEPQLLRDAAQKDEWEFVMTCVAGHFVNKEDLKSIFPTKKFVKPSVDTLDMLRYHSVKMDREMVQYLASGAEESSPESRRSARNVGRRNVEIEFGESSLNELLWPEETKKVIDESLEKSQSDYLHALHALEDLQQQEERFCTKLQEYFSQIIHKAQEPTKQGEDMTWFRVFEQDLTFEAQDTFVHRLRTIIKHTKAMEELAPTPDRAKPWTELHDRAQRLEMWKGMVDATLHQAKDITKCFYKLSDPEADGIGDDESDAAHLDTYDSNRIALRLDPESYIESSTNALMEMNQNMLLFETYRPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMJ2</accession>
    <name>A0A1Q5SMJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_13859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000776">
        <property type="protein sequence ID" value="OKO89224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMJ2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMJ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046874">
        <property type="term" value="P:quinolinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO89224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="17128" checksum="53AD212095452AAB" modified="2017-04-12" version="1">MIVGGPNARTDYHINTTPEFFYQYRGSMLLKTVDTSTMPPTFQDIPIHEGSIFLLPPNTPHCPVRFKDTVGVVMEQPRAENAVDIMRWYCRNCSGVVWEKRFVCTDLGTQVKEVVEEFAADEEKRRCKACGEMAATKYGEGELEQPPAHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNY4</accession>
    <name>A0A1Q5SNY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_13785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNY4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNY4"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="398"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO89719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="468" mass="51069" checksum="E67676369ABB6070" modified="2017-04-12" version="1">MTSARDIRPRADDLAAQAQYLSTSPSASFHSPSSHGSALTRTVPLVNAKHLKPFATEDIKVLLLENVNQAGRDILKQQGYQVEFLKSSLPEDQLIEKIRDVHVIGIRSKTKLSARVLKEAKNLIVIGCFCIGTNQVDLQYAAEQGIAVFNSPFSNSRSVAELVIGEIICLARQLGDRSNEMHNGTWNKVSNKCWEIRGKTLGIVGYGHIGAQLSVLAESMGMSVIFYDVLNLMALGTARQVNTLEALLGEADFITCHVPELPETKGMIGQKQFEQMKTGSYLINASRGTVVDIPALIEAMRSGKVAGAALDVYPNEPAGNGDYFNNDLNTWGADLRSLKNLILTPHIGGSTEEAQSAIGVEVATALTRYVNEGSTLGAVNLPEVALRSLTIDEPNHARVVYIHKNIPGVLRKVNEILGDHNVDKQMTDSRGDVAYLMADISDVNPTQIKELYQSLESLSSRIMTRILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SSM7</accession>
    <name>A0A1Q5SSM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SSM7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SSM7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO90926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="79" mass="8890" checksum="F2B919CB01D9AE4F" modified="2017-04-12" version="1">MSWLELSFTRNIISVVVLFIITPWVYGMGMQNLHILAAAIAFVIYLIPVPLLLWGKKARIATAASYRKMAANQIGRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUG1</accession>
    <name>A0A1Q5SUG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUG1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUG1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="30934" checksum="266653043CAF2DD6" modified="2017-04-12" version="1">MAAKRLVVAGGSGFLGSRICRAAAARGWEVTSLSRSGEPRWDTVTSSPERPSWASSVEWAKADILKPETYKPFLSGASAVVHTMGILLEADYKGVVQGREPLVGGLQRAFSTSKLGSQNPLLRKEGEALEPKERDGQLTYELMNRDSAIALAQESSNEHVPAFVYISAAAGAPMLPARYITTKREAEATISSSLPELRSIFMRPGFMYDSSRKFTLPIALGGFVASELNTFLGNKLGFLGAAAEKPLKVDVVGEAVVEALEDESTRGPVGTKQIEQLATKAWRKTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXN7</accession>
    <name>A0A1Q5SXN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXN7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXN7"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO92712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="187" mass="20942" checksum="8E2CAD57BE14CC88" modified="2017-04-12" version="1">MDQNQGDLNWRLSAHPITLLVFLSIRIGALLMYLFGVLFIDNFILVFILTLLLLSADFYYLKNIAGRRLVGLRWWNEVNTASGDSHWVFESSDPNVRTITATDKRFFWLSLYLTPALWVGLAILAIVRLVGVIWLSLVGIALILTITNTVAFSRCDKFSQASTFANRALGGGIVNNLAGGLLGRFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXX0</accession>
    <name>A0A1Q5SXX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXX0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXX0"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="302" mass="34592" checksum="F95A553F71B90931" modified="2017-04-12" version="1">MLNRPWEGRSVEGYNLRLKKWFEISADGISDVKWNREAFQSLVIERKSKELIQALLASQIDAEKATDLISSKGNGLILLLHGGPGTGKTLTAESVAEIAEKPLYHVTCGDVGMKAEQVEKYLESVLYLGRIWGCVVLLDEADVFLEQRSLEDLERNALVSVFLRVLEYYKGILILTSNRVGTFDEAFRSRIQLALHDPNLGPQQRFRIWATFIERLDKLSTDEEIDIDDLRDHLDYLKDEKMNGRQIRNVITTARQYAKWKKEPLTYQYLKDVIEISGRFDGYLNKLHGGFSNDEIAQHDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZT4</accession>
    <name>A0A1Q5SZT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZT4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZT4"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22076">
        <property type="entry name" value="WH2_WAS_WASL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="433" mass="42236" checksum="985EB4A502D0AA7A" modified="2017-04-12" version="1">MPPPPPPPPPPPGGLGGPPPPPPPGGLPARPSKGEVKGRGALLSDIHKGARLKKTVTNDRSAPLIASSGGGSSAPPIGGAPPVPGMKAPSGLAPPVPSGSAANRLRSNSEGVSGSDGGLGGAAPQLGGLFAGGMPKLRSRGGVDTGANRDSPYMSEGEITRPPAAPAPKPPSAPRPPGSRPPAPPSSESLPAPALNPLIANLKKPPPRPASRPSSTISTAPAKAPDVPPPRAPPPPPGLRKASGAPPPPPSASPAAPPPPPPPAPTSSRAPPPPPAAPGRPGPPPPQSGAPASIAAQAARTALGSTSSPVAPPPPPPSAAPAAPPPPPPPVSAPAPPPSEPPSRPFPGPSRPVSHEPHTTLDPSAYTLTNGGSSPAPGLRAPSTNGPVRIDDTRFKFQGDGLLPKPRPFTGGVRRYRAGRGSSVPLDLSALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0H5</accession>
    <name>A0A1Q5T0H5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0H5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0H5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="748"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="902"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="938" mass="103482" checksum="B74F6CCD99075BD9" modified="2017-04-12" version="1">MIPPDSDDSPLKTSGAGFGLGQEDSTAGLDDFDTQSHASSRDHGSTHAHDPATGADSGGLDNQGDDTTRDAGEGPETGPLDKDGRPAWSEMKTKAGKERKRLPLACIACRRKKIRCSGEKPACKHCTRSRIPCVYKVTTRKAAPRTDYMAMLDKRLKRMEDRVIKTIPKDETRDMHSIGRSVVKPSAQTQATKAQKKRSADEAFAAEMEGWARGERRPTHETFPMSREPKSTDGTGLLTEGAEFLPSLEIQEHLAEVFFDCVYGQSYLLLHKPSFMRRLKAGTVPPVLILAVCAVSARFSTHPQLNSEPPFLRGENWANPAAAIALSRHDEPNITILTVFLLLGLHEFGTCHGGRSWSFGGQALRMAYALQLHQELESDPLLNQNNGANSQLSFTDREIRRRTMWACFLMDRYNSSGSQRPPIGNDKFLQIQLPIKETHFQMEIPGPTEDLDGDVLNPTPENSGQLSNAKENMGVSAYIIRAIVIWGRIVDYLNLGGKRKDPQPLWHPDSGYMRLKRQIEEFSASLPSALTFTYENLQIHAAEKIANQFLFLHIITHQNMLFLNQFAIPLSPGGRPPRDMPKPFLSNAGRAAVEAAHHISVLFDRASAYPLTVPFAGYCAYTASTVHIWGIFSKNVQLEARSKENLRHTYRYLNKMKKYWGMFHYMVESAKDRYRQFADAAIKGSVATQNGTSLAPMFQYGDWFDKYPHGVSRLHWEDPDTRHKETGEDAVMGQKPDLQSVEDFFASLSPTPQHAVPRRSRSRKNSKISDGTPNPNMDHSPTQSMDIAMGNTPGVPGSAFPQPSLFSQNGAMSFGQSPFDFSIPPDQLPQLDRQFVYGSFSDFDPTNFVPPNNSSMPPPPPVNGVDAQTPDHSLFTGHLDPSAPAGTGEFYQPSAWFLPFNLDPIGAGPPPQPPGGPTSAPGPGSDMSGLGGAGNLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0J3</accession>
    <name>A0A1Q5T0J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0J3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="258" mass="29196" checksum="40C2E7A7C129466D" modified="2017-04-12" version="1">MSTTSTTSTPATASTKSTGSSSLNVNLSGFTVPVSTLRENFWPALEAAAAVGLLWLLWCQLQLAVRTRHEYNTGQRVPPYLEHDEDRWSAPSVWRKEWLPWLEEKFGKRRWLLWVWRLVSVLSWPVLILLWVLWDRWDRVCRWFWFKPAPGFGRKPEKRMVSVGSGSSGKSAHILSEEEKGKAGYTKPEGLEPLEPEPLEPPNPPPASDVDKTSLARGPEASASGVRPRSPIKTNFRVKTRSSSPQHPFFGHPDQMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T212</accession>
    <name>A0A1Q5T212_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T212"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T212"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO94283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="615" mass="66862" checksum="40C9D9907ED077A2" modified="2017-04-12" version="1">MADLPVYDGAIGIDLGTTYSCVANYEGTNVEIIANDQGSYTTPSFVSFTDKERLIGEAAKNQAAMNPKNTIFDIKRLIGRPFDDPIVKKDVESWPFKVVAQGTAPAVEVEYLGENKTFTPQEISAMVLMKMKEVAETKLGKKVEKAVITVPAYFNDNQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLGAGKSDKERNVLIYDLGGGTFDVSLLNIQGGVFTVKATAGDTHLGGQDFDTNLLDHFKKEFQRKTGKDLSGDARALRRLRTACERAKRTLSNATQTTVEIDSLFDGEDFNSSITRARFEDLNAKAFSGTLDPVQQVLKDAGMEKSKVEEIVLVGGSTRIPRIQKLLSDFFDGKKLEKSINPDEAVAYGAAVQAGILSGKATSAETQDLLLLDVVPLSLGVAMEGNIFAPVVPRGQTVPTIKKRTFTTVVDNQSTVQFPVYQGERTNCADNTSLGEFTLAPLPPMRAGEAALECVFEVDVNGILKVTATEKTSGRSANITISNAVGKLSSTEIEQMVEDAAKFKSSDEEFTKKFESRQQLESYISRVEEIVSDPTMSLKLKRGNKEKIESALSDAMAQLEIEDSTPEDLKKKELALKRLITKAMATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2G8</accession>
    <name>A0A1Q5T2G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2G8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2G8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO94396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="989" mass="106074" checksum="32309B092F388EF9" modified="2017-04-12" version="1">MPIKLPKGFARRKSSGNVLDDVDGQPQSSFRVFERPGAQQRSMTDGAPLTKRMSEGHASLEDNDNIFAGSEHPLGKTRYGRPRTMESLRKGLTGRHHSGPTYESSTSTRLSSSSTLPSSTEVPPPDEASSPHSRIHDIPAPPPLAGALRAAAGRTFSFGGRFNKNSTPPAPPRNATPDATKQRAYSGSTDDTATPPRLPDSQLNFDLGAGGDDFGKMFDHLGKRESALLRDPSPQRAKQYSSSPPTQALPEFQATDNRAGRPTPINTDRSVAVEPSPYSWGSRHSGDNLLNSPSGEIVTSPARSTAETVTSFRKPSPSPAHMLGATTSHRALEKPGRRPSDGLRRSGIYPGDRDSNTVDDEDAKMVRQSVLWSKGSSPRWEEATSPSGETPLLDKGKATSPSLLSPTADEGLFAPRRSPAPSDHDLDDARLAVQFAESLPKTASPAGNKVMTPSQFEHYRQQQELRRSKSDATKSDEESEHEEFDDEEDEVEKQREAEKQRRKQEAHLSLYRQQMQKVTGQQAPSPLLRPEMAGASNSTPNLPNRLSNPIDKSSSGKSSNEEDDEEIPLGILAAHGFPNRNRPPTRLANVSSHPNLRASMHPYSTSSTSLAGAEAGNRGSLPVFARNLPQDPYFGARIVNPTNRESLAFGGGSGSVYGGASSPGPPPGGLVGVIATEERNRAARRAGGGSPNHMAMYDQRQMAMGMGNPGGVPRPFSMMGPQPMTPSELAQVNLSNQMQNMMQMQMQWMGQMMQMQGMPPGMQGMPPGTPPMMAGAMPPQMMGMPMQGGPMGPPSMAGSPSVMGLNPNFRPMSMQGPPGAMAPNFEQQRTLSMLDPNIAARRGSPMPNLPGGPPFRPNTGGYAPSIAPSERSNAGLASRYRPVSVMGGEPGPGVSALNKGWNDENHHSSLSVSQSHMGLPKSSSLATVTVRPVSRASQSPAGRKPVHASDEDNDDEGWADMMKKRDKKKSSWKLKRGTSSLGDLLSAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2M3</accession>
    <name>A0A1Q5T2M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic dynein 1 intermediate chain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2M3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2M3"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="694" mass="76098" checksum="9DB6FF3D9D8CD1FF" modified="2017-04-12" version="1">MSSVQQRKNEILAKRAKLAELKKQRELRQKEFSNNRNSIGDTSEIASPVPSRSDSRAELDDLISRLVDRPGSASISHGADGQSRKGSRPNSVLSASQLSGENTDALSPTSRPLLQSIAVQTVGEEQPYTYSAPEVQAPPPPEGKPELVTYSKAVQTDGLESPPQSEDGSVASDNEEQAGTTRSSKRLSRRDRERDEEIRQKIRKEIEEELQATNQDGAAAATTQSAQLRYPLRTLDDDELKAVTSSNDFLDFVERSSKVIERALDEEYDVLADYELGVNGDVEEDEETGKKRRGIREVCQFYDERWSKKRMVTDLSFSPKFPELVLASYTKNPSAPHEPDGLVQVWNQHLHSRPEYVFHSTSDILAAKFSPFHPNLIVGGSYSGQVLLWDTRSSRAGGGAPVQKTPLTGSGHTHPVYSISIIGTQNAHNILTVSTDGVVCGWTVDMLSQPQEFLELTTPPPSKTEDLAPTTMSFPQSDPTFFIVGTEEGGIYPCHRYDRAGAKAGTDHRLAYRGHAAPIMSTAFHPARGPVDLGDLMLSSSLDWSVKLWRVRPPATTAALTSGMSSAQVVSPILDIVRDDVVYDARWSPHRPGVFSLVDGAGNVEVWDLYTDTEVPVVRTTPSRGPSAMPSRSLNKVAWEEREGRRLATGGLNGVVTVFEVGKGLGGPSEEVPAEEWAGMKRLVSKLEQKDRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T3G4</accession>
    <name>A0A1Q5T3G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000714">
        <property type="protein sequence ID" value="OKO94772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T3G4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="142" mass="16277" checksum="54D1A755D97AC3F3" modified="2017-04-12" version="1">MEQDLQSEVDPPPGPAISEDPERPSWGDQPFAPAMEALARLERGDPKLAFQAARIVGLYRRLWESCMAKHMEGKKLAKANDGLRETQQKLMNEKNEMQSSHDNQLARLHFLDQALECSRLRLSEILKEWNRYSDGLESKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5S7</accession>
    <name>A0A1Q5T5S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Digeranylgeranylglyceryl phosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5S7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5S7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38180" checksum="8352F804644C0861" modified="2017-04-12" version="1">MATDVPGIPRHRHQAVKRPLPVQRLLSLMNHAAEQPGHVIHSIWLFTYSDLKTIIATSFGFGLLTSMGAASFGIDPAPAWSFCFQRVPLVLLWAWLNLLPFTIDNQRQPDAIMEDSINKPWRTMPSKRMTPEHAQVVMFIFYALALVTSIRFGGLAQCITLIGLGFWYNDARGADFSCIIRNLINGLGFMCYTSGAVQLELGPSQWQSFIRPDGLGLPWLAIIGLIVFTTVHTQDLYDQAGDSARGRKTLPLVIGDANARWVTAAFMLFWGIVSPCYWGWLQTGQSGVLFWSGAYMAALACIIAGRTLMLRSVPADKTTFLLWNLWLVSQYALPLCAGLGRAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5X4</accession>
    <name>A0A1Q5T5X4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_11077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5X4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5X4"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO95565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="291" mass="32294" checksum="2EF4FD4DAE12D061" modified="2017-04-12" version="1">MSALRYRPWRALKTLQNANALSQASRTRISPSQPSHLITKRAITYSSTRSQTPTNNNSATSQTPRSTSSTTSSPSSSLTQASRVAAPTPNRTTTDNISKSGLADKPLELEAAPEEKIDWTRSFHGLSAEPFPKEAADILLAETAPEEVEIKPDGIVYLPEIKYRRILNKAFGPGGWGLVPRSESIVTPKTVTREYALVCNGRLVSVARGEQDYFSPDGIPTATEGCRSNALVRCCKDLGIASELWDPRWIRKYKAKYAREVFVEHIVSKKKSKIWTRKDDPVGYPWKESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T854</accession>
    <name>A0A1Q5T854_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T854"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T854"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="290" mass="32218" checksum="83097115BFEB5656" modified="2017-04-12" version="1">MEDETTPRSRMMIDTVKWLLDANPDTINARDQHGATVFSYAVKSRAVGIAGILAAVKVLLNARRPSLTLDPILDEESDPVDATTATTGTSTLLQDTVTSYSRRFNNVRDERFTELIETFLEHGADARLCLHRLCAGIWSVSISLSMLDRLLEPPTNINDTDADGCTAMHYLVRHLDQIQAARHLIKRGADVSVVNHKGNTPLHELMKGTMLRHLDKYGKPDPPQPRDAPARAREEWIKVLLEAGGSMHQTNAAGQTPAQLLDELNERIQRHRQAEAARGRGRGRGRGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T875</accession>
    <name>A0A1Q5T875_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_10618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T875"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T875"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO96443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="45152" checksum="C11A703C1C17EA33" modified="2017-04-12" version="1">MSTTTCLQLDELQKQSTSFHRYIFSSPSVTSTTIKEEEKRLVSQTVEARQSVLLLKGIREQYTLVNDHTIPAILHPGEILVKRRHFLTTYWQVLAIGLNPIDWKAPAFNFGIPSLPWINGRDLAGLVLQVPSENSRVRVGDIVLVPSTDYRDIRKAAFQEYAIATDFNAARIPSSTSIHASASLGVAFVASVLALGVSFGLDFSVLSKSPGPNLPRIIDQLEQNTIPADIQDECFVSESERPKRGDWVAIWGAKLAGLRVICVADAARHGAKLLESGADLIVDRHDTNRAVEIIRGITGGKLRYAIDIVGKETATLLEKTLDPSGHSHLLGLTGLPKERNPGIRYHTVPIKLFHTAPTVGESMVRWLEDLLQSNTLTLPEIVRAEGGLEGINAALDLLRSGSVSGKRIVVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8Q4</accession>
    <name>A0A1Q5T8Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8Q4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8Q4"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="534" mass="58808" checksum="6270B3B0DD631C78" modified="2017-04-12" version="1">MVYGGKPSTGCYLCRKRKIKCDEARPSCRNCAVYRQPCPGYRPDAVFRNETRKIERLAKKDASSSSSSSSSSIASSSTPTSKTNTPTAQSPTLTETQARQPQESALTLQRVQDSTWEQRALCYFFDQYTITGEGEDGMGHLEYLPSLYARCGEVSPPGELSPSVCLRSAVNATALMTLANVAHAPPLMIKARQGYGKAIRSLRAALASPSQAVQDETFASVVLLSLFEDITGERNGLFSSHTAGFEFLMKLRGQDQLGHQQGRDMFNFAYTHTYVEILALGDKPRCDFDWVMDMLDENDPIESLMLAATKMSQLFLSMQAAPNPPDQTTVESWIAAGLECDSVLSQWTLHLPDRWLPLAVYSPQGEPLLTYNRISNAGVWGYYRAVRVMLQQLLLNLNRTLTSITQKNQQPGGDTIPVESKLDETSLRAVIQEMTTDTCRSLPFSLSDVDNLGRPTKPNDNSRPIRAAQAYGMLWPLWYILSCGMPTSTQAQQIRTVLARVGSSLGIKLALILASEAERMRGDSQPVGTPVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8X1</accession>
    <name>A0A1Q5T8X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Scyllo-inositol 2-dehydrogenase (NAD(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8X1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8X1"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000132">
        <property type="entry name" value="NAD-binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF11">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="137"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="39389" checksum="1AE7706D57896ABD" modified="2017-04-12" version="1">MGIQKLQVGMAGLGRVGKIHAINFLQRTPRAQLVAAFTPDPNEISWGKLNLEPHGVTLYTDYDEMLRHPGLQAVAIGTATSVHAEEAIKAIERDLHVLCEKPLSIDVEVCKAVVQAAKKKPHLKVMCGFSRRFDESYRDAREKVEQGLIGRPSIIRSQTCDKFDPSGFYVEYAAWSGGVFVDMSVHDIDLTLWFFGDDIIPKSISAHGITAVQPELKKHKDYDNAVGIVEFQNGKIAYYYCTRMMAHGQEDTTEIIGTEGKLAVNSNPQRNFVNLYHSGGITREVPPNFIGRFGAAFVQEANEFTVACLDNTPLPMKLSNAVKAVEIGAYLQEALVTGQQIHFDEIGRRIEKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9G1</accession>
    <name>A0A1Q5T9G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein Dcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9G1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9G1"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO96884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43783" checksum="E2E78463B50B4197" modified="2017-04-12" version="1">MATQDSRSILFTNTNPQQGFRLLELTPELEKLLTSKDAPALELKTPSAALARAVVDPSAPEYVNLCTPSQTYRIRQVQSSNSLHILRPSLGQISRADIKVVEEEAGETGALNLPDEAVTAIAKCGSTLELHVSPGGFSAVPFLEKSLGLYEKRTGDDDGDISMDETANGSGSLSPVETRKLRDRVFADIPVSSAQCEAGWTGICAFVDEKQGACWRPSARMRLNVWKRLMQGAILQGIDLEKQFLVWDLWKSVLDDDDDSEPPFPRALLEAVARRLCVADEGPSLADEIKWASFDKTECTKWVGETYLAATAPTTSSAIGRSDFLRAWKDCLPESWREEATLSKLQEGSYQSPDPTTICFVVPSLRQQVSKTSAAAPAAAAKAKTTRNWHELLKNPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAT5</accession>
    <name>A0A1Q5TAT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAT5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="67" mass="7499" checksum="77A6487F6A714610" modified="2017-04-12" version="1">MQSCNDPVPNQIVERNPEPEESRSTRTLNRAKKHQVAWNKQRSMRDRPSGAQGTKTSLAFSCSLAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAY1</accession>
    <name>A0A1Q5TAY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAY1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAY1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012231449" description="DJ-1/PfpI domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="50"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="249" mass="27573" checksum="BD8E82A3D5CE7BCF" modified="2017-04-12" version="1">MVSEPLRIGVLLVNCVQLLDLAALDLLYMASPEWLEEIGMPKHLADLGRPCEIHYITRDGPDKMASVTSDLSIRVNSTTKDSAVAPGNLDILFLPGPSPRVMPPAEDYLEFVRKHNVVETTIMTICTGALVAAHAGITKGKVGTSPRFLIPYMKKTFPDTKLWDHTLRVTRDGNLWMCDEGGITNGHDLVAEYLRENYPAPLVNTVLGAADVAQRPLQYQTTATRDSAFFMWQIIRAIPSSIMRMLTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAY8</accession>
    <name>A0A1Q5TAY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAY8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAY8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012886117" description="Glutaminase A" evidence="1">
        <location>
            <begin position="20"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="340"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="73002" checksum="8178662A52EA0094" modified="2017-04-12" version="1">MQLWHFALLVSSFVASVGAQSTFTPARPPALPLAVKSPYLSTWLNAGSDGGNGGYLAGEWPVFWGNQITGWCGLIRVDGATYTWMGLPGSNTVTQTAFEYTSTKSIFTMDVGGKVEMNITFMSPITPDDFKRQSLIFSYLNVEVSSLDGNDHDVQVYADISAEWVSGDRGTTAQWDYGTTDGVAYHKVWRQTQLAFSEINQQAEWGYWYWSTDAANGMTHQSGQDTVVRGQFSSNGALTNEADTNYRAINNAWPVFGFSSNLGTVNSSPVSTLFSLGLTQDEAIQYEGSSGYGPVPSLWKSYFTTDVDAVTFFHKDFSDSSALASSFDSKVATESIAVAGEEYLTLTSLSARQAFGATQLCGTESKTYLFLKEISSDGNMNTVDVVFPAYPIFLYSNPEFLKLVLDPLFENQEAGHYPQSYAMHDLGSNYPNATGHNDGNDEAMPLEECGNMIIMTLAYAQKAGDTDYLSTHYTLLKKWVSYLIDEALYPANQISTDDFAGSLANQTNLALKGMIGIQAMSVIAKETGHTADAANYSRIAHDYINQWQTLAINKNVTPAHTTLSYGDESSHGLLYNLFADAQLGLNLVPQYVYKMQSDFYPTVANRYGVPLDTRHTYTKGDWECFAAAVASADTRDLFIKDLATWVNETPTNRALTDLYDTGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBC0</accession>
    <name>A0A1Q5TBC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetate permease A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBC0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBC0"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="278" mass="30246" checksum="2D4C62E2A15BD27E" modified="2017-04-12" version="1">MDQFIEKMEIKQAQAEAKICSQPTVDSQSPTPVGSQSGHEYALVSPGTPVGRPPIPKPEEIHTIPEVRKFANPAPLGLCAFALTSFMSNIMNVHLDLTTAAENVGSALIYGGTVQLLAGMWEMALGNTFSATSFCSYGAYWITFGVISDLEGTKIIAASETVCQKEILMGLFLLAWFIFTTMMLLCTLKSSLAMFLLFFFLDMNYLLLGIANMQCDQGHAAVTIQRVGGYFGLLAAFAAWYNAFAGIFDKSNGFFNVPLGHFPWSPAVRAHHGKFKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC85</accession>
    <name>A0A1Q5TC85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">PENSUB_9764</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC85"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC85"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001420">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012795837" description="xylan 1,4-beta-xylosidase" evidence="19">
        <location>
            <begin position="21"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="694"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OKO97838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="792" mass="85980" checksum="83D9EA6A4A935A48" modified="2017-04-12" version="1">MPATTALLAALAALVPTALAQANTSYIDYNTEPQPSLDSQTLGKVHTGFPDCTTGPLSNTLVCNSSARPHDRAAALVSLFTFEELVNSTGNNIPAIPRLGLPPYQVWSEALHGLDRGNFSKSGDYSWATSFPSPILTMAALNRTLINQIGEIISTQGRAFNNAGRYGLDVYAPNINSFRHPVWGRGQETPGEDAYCLCSVYAYEYITGIQGGVDPEHLKLVATAKHYAGYDIENWDGHSRLGNDMNITQQDLAEYFTPQFLTAVRDARVHSVMSSYNAVNGVPSSANSFFLQTLLRDTWDFVEDGYVSSDCDAVYNVFNPHEYAANISSAAADSMRAGTDIDCGTSYQYHLNESFFQGEISRSEIERGVIRLYSNLASLGYFDGKDSQYRNLTWSDVRATDAWNISYEAAVEGIVLLKNDGTLPLSKKTRSVALIGPWANATTQMQGNYFGTAPYLTSPLNALKASNLDVTYALGTNISSTTTGGFADAVSAAKKSDVIIFAGGIDNTIEAEGMDRQNITWPGNQLQLIKELSGLGKPLVVLQMGGGQVDSSSLKTNKNVNALIWGGYPGQSGGQALLDIITGKRAPAGRLTTTQYPAEYALQFPATDMSMRPAGNNPGQTYMWYTGTPVYEFGHGLFYTTFKTSLSKGSDTKTSFDIVNLLSRSHDGYNVIEQLPFLNFTVSVTNTGGVLSDYTAMLFANTTAGPQPYPNKWLVGFDRLGSIKPHASMEMTIPVSLDNVARTDSLGNRVIYPGKYELALNNERSVILSFTLTGDATTISKWPLDKQQIPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDV5</accession>
    <name>A0A1Q5TDV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter C family member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_9496</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDV5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDV5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="177"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO98398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="46194" checksum="1E34E671497947FB" modified="2017-04-12" version="1">MPLLLAVIWFVQRYYLRTSRQVRLLEIEAKSPLYTHFTETIAGISTIKAYHWQSQFQQTCDEHINNTQRTYYMLLSIQQWLAFILDLLVAVMAVVIVSITTCLHDKFSPGEIGVALNIVLTFNDALAQAITSWTQVETSIGAVTRVQRFRDTTPTELRQGATETLQSVHDWPSRGAVVFHQVTACYSSNTPPALTNVNLTIKPSEKIAICGPSGSGKTSLILALLQMIEVRSGSISIDGRDLQSLRPGDIRSRINVTPQDPFFIPGTVAYNLDPTATASNVLIETALRKAGLWEKISYAGGLSADLQPTSWSAGEKHLFALARALTNDSQIVILDEVTSSVDTTTEIIMQRVIQEEFPNRTVIAIVHRFGNIDLFDRVAVLQRGEVVEYDTPKTLLSQDSKFRELYVSSLGHSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG47</accession>
    <name>A0A1Q5TG47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG47"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="11132" checksum="BA60AEDEF78B7E66" modified="2017-04-12" version="1">MVHPASTCCKTTQGAGCVCAAQAKCSCGKESALHCTCNKASSENQISGARCSCRSRPAGQCTCERAVTENKPVQGETCACGSRPSASCTCEKAEAVESALEQDFTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG63</accession>
    <name>A0A1Q5TG63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_8606</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TG63"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055440">
        <property type="entry name" value="Beta-prop_WDR90_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23342">
        <property type="entry name" value="WDR90_beta-prop_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="WDR90 4th beta-propeller" evidence="5">
        <location>
            <begin position="330"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="447"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="614"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="655"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="697"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="739"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO99219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="876" mass="96209" checksum="294837B44AE103A5" modified="2017-04-12" version="1">MDGLSSAASVIAIIQLAGSIVKFCGGYIQEVKDARDEIFELQRTVADLAGILQELKVLLQGPNGAKLSSSHTLNDPFTKCHLTLTSLEATVDPGKGKRVIKKLGFRAWKWPLDRIEVKKIIEDLERYKSSFTLSLAIDQTIANYDYEILVLHEVSDSEIKNDISLFLQHRLAEIKAERSMPIDWPTNTDFNNLVTLSVPLFIFAATACRLFQDPHWDPVDSLADILAYRNEGSKLEGMYVPVLNRLLQKQSKKQEEQLVQEFREVVDVAKTWSAELQTLEGHLGAVYSVAFSLDGRLLASGSWDKTIKLWDTTTGALQQTLEGHSDSCRSVVFSPDGSQLASGSCDKTIRLWDTATGALMQTFEGHSDSCKSVAFSPDSQLLVSGSEDKTVRLWNSTTKALQMSLHGHRGAVYSVKFSPDGHLLASGSEDKTIKIWDPTTGVLQQTLESHSGWVCSLAFSANGRCLASGSNDRTIRLWDTTTGILQQTLKGQDGFQSVAFLSDDRTLVSGSLDKRIQLWDTTTGALKRILTGHTVGVRSVASSPDSHLLASGSQDGTVRLWDTATETPHEALQSPSDRIRSMALSPDGRLLALGSDDTIVRLRNISTETTIQTLRGHLHWIWSVVFSPDGRLLASCSRETIRVWDVATGDLHQAFKSRLGEFRSIAFSADGRLLASGSCDKMVRVWDIAAGALKRTIEGHSGWVWAVAFSANGHIIASGSDDKTVRLWNAATGAVRQTLEGHSGWVRSVAFSANSHILASGSDDKTVRLWDIATGALRQTVNVEGTVVELQFSDDGTYLITNLGYISVQSRYVDHISKPLPTNAQIFIQGLQWITLQGIKALWLPPDFRPTCSTVKDKTLVLGHESGRISTIEFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TGP7</accession>
    <name>A0A1Q5TGP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_8732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TGP7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TGP7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO99345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="282" mass="31582" checksum="89B39DD04AB65755" modified="2017-04-12" version="1">MAPKQTLQSKYKLLSGHEIPVLGYGVYMIPPSSTEKVTLEALKVGFRHVDSAIMYRNEKGCGRAIQNSGLDRSDIFLTTKIPPESMGYDDTKRAIDSSLRQAGQEYFDLILIHAPYGGKEARLGSWRALVEAQKAGKTRSIGVSNYGIHHLEELEEYIQSGGGGEISVGQYELHPWLDHSDIAEWCQSRGIVVEAYSPLAHGTRFREPVLRSIGGKYDKSPAQVLIRWSLQMGFVPLPKSVTPKRIQENSEVFDFELDEEDMKSLDTGEYSPTDWDPTVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TH34</accession>
    <name>A0A1Q5TH34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000656">
        <property type="protein sequence ID" value="OKO99530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TH34"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="100" mass="10785" checksum="B8D5D27593BA13D7" modified="2017-04-12" version="1">MVYDASQIATVSNNSVNATANVIQDTCWGTPAIVVKNLASGIYNAGPLPQPLVYKNTVWSPIQFIGPNGFFDLNSSTVAPTWQAWDALLTHLSAIPCIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THE0</accession>
    <name>A0A1Q5THE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_8300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000655">
        <property type="protein sequence ID" value="OKO99647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5THE0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO99647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39323" checksum="3229ACB13D1F8F87" modified="2017-04-12" version="1">MTAQTCDSCSTTKCVSTSTNTAPPAKGTNVGAIAGGVVGGVIALAVLLFLIWWFVIRKRRNAQAEEKDHSAFNAARDGRQSTQSIASTVLTRASNVIQIAYIPGVTNRSPPETPATLVPPVPPLPGAHPDQHFFMPGDLRDSSWTTMTGHQSMSPTLRSSVATTVYRSDAIVSATPAQQIQRSRANIVSVHNGPGGSGASTPTQPVPVMITPRDAPAVPAITSTQLAKAGAMAQSGSSIVARQVMAKPVMVRGQSVKKKDGQAVTNKAAEADKKPTTAGSDSSRQFDHQTSTFDGNSSDEEGDETRPTTSSTSTKAKTTSTSEEATQDAGPFQDHLSTSEANSSSVDQKRTSRHSNKTPPPRVRSPFSDDNEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIE5</accession>
    <name>A0A1Q5TIE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_8212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIE5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIE5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO99995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="253" mass="27852" checksum="F139812DAA6DA21D" modified="2017-04-12" version="1">MHSASELRPCSRDMCSITDEDRFGPVVNNCAHDFDFTLLFEEVFFSISLSACFIPVIVAAFFYSRRQIVKLRTGWIVIVLAATHHNGQSLLLFLSKTFHREILAGVIPRLAQAGFTLAQPYIIRRAVILLATPEAPNSRNRGIALVAAFAIVYVGLAISTAQAQHKSCRLVAMFRGGLVSIIFDKAISLSATSQNEASAMTAMGIEIERIAAGLQCFHDTWGSFVEVTLGLWLLYYQLWAADAVPILISVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TII6</accession>
    <name>A0A1Q5TII6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell pattern formation-associated protein stuA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TII6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TII6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="9">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="631"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP00025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="818" mass="90031" checksum="91DBA8B3D43A75E4" modified="2017-04-12" version="1">MSSFGVSNGASRGSFNGNYDGGNDYGSMMPYQEEFKPQIYRAVYSNVSVYEMEVNGVAVMKRRSDSWLNATQILKVAGVVKARRTKTLEKEIAAGEHEKVQGGYGKYQGTWVNYQRGVDLCREYHVEELLRPLLEYDMSPDGSGGPSQSTLDTPTKEQAMAAQRKRMYSGAENRSMPQPQQGTFFQNISRTAATAVNAISKARFDSPSGNSRRPSVIRKPSHQMSSQESMAFSSQQSMYNMSDSGFSSLQNRFQPHDDREEFVEPPRKRVRSSSHIGPQIGLHREPSNLSMHEPTPTEPNESFYQDLDLPPPPMDDGHKRGAEAIPPASDPEGFQKQKLIMTLFLDKRIKDFSNHPALMQLTGEDLEIPLDEYRNNALHWAAMLARMPLVHALVAKGASVARVNAAGETALQKAVGTRNNLDYRSFPRLLQVLAPTIDMVDYSGRTILHHIAVMAATGGGGHVSAKHYLESLLEFIVRHGGITSTANGDHSQNGSQGSEVISLGRFISEIVNLRDEQGDTALNLAGRARSVLVPQLLEVGADPHIPNHTGLRPADYGVGVDMVDGNGQSQQAGGRNDTFIDQLAKSKKEILDAALSQINAMVEEALGGIDRDLASSITQKQEKFDHWHSKIREAAKARQIEQKQLDVLKQKGSERVEIDRRIKNLERSSEGLLGTLKSTPGIDFARIAVIGDADKSSGVDPATFDVLFGETFDPSAGFSAQQVAFLATLPSPDGLKRRTRCYQELNVGLTAEVDALKAKNAVLGQNYRRMVMACTGWSAEQVDEAAEGLTQCVKELNDNPVPEDEAIEILMRDRGQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJK8</accession>
    <name>A0A1Q5TJK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_7860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJK8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJK8"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP00403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="296" mass="31236" checksum="E8789F1C85613FEB" modified="2017-04-12" version="1">MDILQKTVVDPLQPLLKPIVEALPQPVHDAIISLITAPCHAALLLDLSLVEDPSCTSLAISKALGIAIVGASAIVKVPQILKLINSRSSAGVSFVSYALETASLLITLSYSVRNEFPFSTFGESALIAIQDVAIGILVLTFAGRPAAAAAFVAVVAASVYALLFDQTLIDGHTMAYLQTGAGALGVTSKLPQIYAIWSEGGTGQLSAFAVFNYLFGSLSRIFTTLQEVEDKLILYGFIAGFSLNLILAAQMVYYWNSPAPKKKAPRAKIAEKPVSAESSGASPRPGSKTPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKI1</accession>
    <name>A0A1Q5TKI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine-protein kinase psk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_7661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKI1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKI1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="235"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="497"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP00730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="593" mass="64594" checksum="E574B20DB9E67617" modified="2017-04-12" version="1">MPSSAPPDDISVGDVFTPQADLAQPSAVDIPANHRAPAVHMGDDQLSPRKQIANYMSNGDNMMQPPVFHPNLLSGKQRRKAKKKKQAGQADPALSTVRGFTPLASADEDSDFSTTSSRAAESRPATSKGGASPRAQPNTGHGVSALKLQLDSLNLSGKPTAGTGGFCSGTPSNASVYSDSDQTEILTSYEVPLEHDFVSADAAKDEEPASMGPAAAGNGADLRSQLCRKMTAEDFEPLLCLGKGSFGTVLLVRHVVTGKLYAQKQFKKASITVHKKLVEQTKTERMVLESVSRHPFVVKLFYAFQDHEKLYLILEYAQGGELFTHLAMERMFQEDAAAFYMAEMVLALEHLHQNVGVLYRDLKPENCLLDHHGHLLLTDFGLSKIALSDDDRCNSSLGTIEYMAPEVIQGKPYGKACDWWSLGALGFDLLTGSPPFRANNHTKLQEKIVKQKLVLPYFLGPDAKDLLIRLLRKDPAKRLGYHMPKDLQTIKKHRFFRKVDWAALERRELDPPIKPIVTDPALAENFSADFTQIPLSPTVTTGGFDDLYAQSQSRFSSSLAGQTGGEGDPFGGFSFVASSSLLDHGLGVMATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKM0</accession>
    <name>A0A1Q5TKM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKM0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKM0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="152" mass="16885" checksum="4DF396815C73DCCA" modified="2017-04-12" version="1">MNSKAAKKADASREELIKHARDSYLKASKAGGEHYASATKNLAEATGTAKQTTFDNWSQSDLKKYLDSYGIPVYQGSNINELRAAARRHATYFRFGTTNPQETIYAKVMDTLHWALEKLKVGASSGRVQGQEAAEKVREKAAEQTEKIRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TL64</accession>
    <name>A0A1Q5TL64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitotriosidase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_7549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000642">
        <property type="protein sequence ID" value="OKP00968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TL64"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TL64"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="102" mass="11665" checksum="C24D433B829299EA" modified="2017-04-12" version="1">MRYCAAERYQRSPDEEFYVDFNALKDRKPGLKTFISVGGWDAGGKVFSDMARFPGTRSAFISSSIALIEKYGFDSIDIDWEYPAAEDRDIPHHYPPPSDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQ66</accession>
    <name>A0A1Q5TQ66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_7140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQ66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQ66"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP02376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="62" mass="6655" checksum="47C558E4F2562527" modified="2017-04-12" version="1">MGSHSSDDNIYLLGRDEAETERLNKQHRFLVAISGDTLIHPSIPKDTISAVADIGTGTGYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TQD2</accession>
    <name>A0A1Q5TQD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000626">
        <property type="protein sequence ID" value="OKP02412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TQD2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TQD2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP02412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35379" checksum="CAF1C140AE0EC7F5" modified="2017-04-12" version="1">MGIVWSQFFPPKPTLTEANLPSQKGKVFIVTGGYSGVGFELCKILYQAGGKVYLTGRSEEKALQAITDLKTGSPNSEGEIVFLPLELDDLTTIKPAVEKFTSVESRLDVLFNNAGVSNPPQGSVSPQGHELQLATNCLGPHLLTQLLLPTMKQTARNETQASVRVIWLSSIVVDASAPSNGVNLDDFLRRDAGMNRNYEHTKVGNWFLANDLAKKVGEDGILSVAVNPGNLKSNLTRHFPSWVPILVAPLLYHPQMGAYSELWAGFSPELTISDGGKYILPWGRLHPKPREDLLRAMRSKEESGTGDAALFIQYCNDKIEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TSK1</accession>
    <name>A0A1Q5TSK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_6909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000619">
        <property type="protein sequence ID" value="OKP03205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TSK1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TSK1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="3">
        <location>
            <begin position="259"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="813"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP03205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1272" mass="144481" checksum="8B8B343FF1D23D47" modified="2017-04-12" version="1">MSKHPVSPFHQDWSKRCSFCGVTLLSQESDGWCCNKGRRRLPKRPQCEELLEPLLDSYRGRLSAISRRVNNPFAFSAIGTSGRFVHFQGLANVVLEGRVYHRLLDVAEKGHSMHWFLYDETGRAEHAKRLDVPQDVVQVVRSFLSQVSPYVRCLSHAISQTTEQAIPLGIELCVPPAGGELASVINTENLRQISTRKIVFFRKGDRRPRFVPILSCQYEPLQYPLLFPHGTSGWGFRAPSQKNLPCSQIQWYRHLFLTEPRLQIFGRLACEYAVDMFSRTEEERLHFLKTGRRQQAVGMDEAQDPAVPDLFQNKIPASFMDSRAWASDQVADSLAIARQLGKSSFFLTMTTNSHWPEIQSRLLPGQDVTDIPAVVCRVFSRRLLALKAFLRQNFSRILYEISVTEFQKRGLPHAHIIIKVSHEPPLSVLDTIISAELPNPVEKPWLYTAINRFHIHSRDHLTRPTSRCNRNGRCIYGYPQPIALHTYIDDIGRVHYRRRKEEDRWVTPHIPALVELMDCHIFVDVCSTAVIFLYLFKYLFKGPDRTRFSLPALSSPQDGNELVDEYEDYVSGRYLSSSEAVYRIFGYDTVRKRPAVRCLSVHLEGKNLPRMHHPAAPGFTAMSDLLWYFQRPRTADLQELKYSEFFSVYYLQTRPFDIPLETTQHPIITDLRTVRGHCYPTYQEAATALGLFQDVHEAVYAMNEAIRAYSRPSQLRFLFAYLLLDLPFPAVELWTQFQQELCVDYRLHHHPVESSNLALADIARYLSAQGSTLSQCGLPEPHYHASELDLELNFFCDRIPTLRRRSEDAYAKMNADQQNIFDRILSHCGSSECFFIDGRAGRGKTFLVSTICDRVRGDGQIACVTGTTALSVIHYERGRTAHSAFGIPVQETDVGLESRISVHSGRAELLRQAAIIIWEELPMAKKAIIECANQLLQDIMGNNLPFGGKLFIGLGDFRQVAPVIRGSSGPTATLNSSIRTSDLWERFKILRLTIPIRNAGDPVYARWVDQVGDGITPYETSVSLQHLRHLETLGEAANFLFLNDGLQTSPAAVHRAFLSPFNARVDLFNLLMLDRLSGSPTAYYSQDTIKELDDTTFHLPAGAEADLLSILHESGVPPHALSLKIGCIASIMRNLSIEKGLVKNARVQVVNLLPNVIEVRLLQQLQPVPEQTNSPFYLPRITFEFKPLRANWTVQRRQFPLRIAYATTFNSCQGLTLDCVVLDLAMPVFAHGQLYTSLSRVRTAPDICILRNPDETDHSTLNVVYHDLLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TU66</accession>
    <name>A0A1Q5TU66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TU66"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TU66"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="2">
        <location>
            <begin position="159"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP03776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="428" mass="44722" checksum="5F3D89E319059C6A" modified="2017-04-12" version="1">MAPASATSQRSNDKSKRQPSQAPSTSKAGSESPVSEANGTEPTYLKELQKSLRNTAKKLNATAKIDAIIAENEGKSLDDLVAEKKINADQKAQALKKPALQATIAQIEEQIGHYKQFAAQYEARLESEKAALEKAHQEELEAVRANAIADATETSARVLREQLLTLTKFLCAAANMRHAGETESLESRAFEGVLFQVYGGNKKAVDSMVKLVEGADEKVIGVEGEALELSYGDVKLASNKFAPAEVTTEVTTESAVVSDPTVANAGLTELQDPSVSDELAASEAANATPQAGQVAPPAQTLISDAANQIAETTYNPTSMDSSATTDGWVEVPRDPAETETGLQATPADVNNNTATAKETPAGAKGQNGGHRGRGHRRPRGGEGSRGRGGRGEFRGRGHGAGRGGRGRGGSNASPAATPAPSNQAAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUB5</accession>
    <name>A0A1Q5TUB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUB5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TUB5"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP03817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="438" mass="49459" checksum="70C4AC4CCF53406E" modified="2017-04-12" version="1">MASRSFMPLRRSFAQLSPRTSRIAGRNAGSSVRGYATENSSRPKQQFTVWRPYLRLAVGVPFIGMIIYSMATGEVTDLDAPSIAELDAALKQSSEITESSPMRLRMEKLIKHQQQKIIAELARIDGKEFKQDTWTRPNGGGGISCVLQDGNVFEKAGVNVSVVYGELPRPAIEKMRADHKSFVGSDVDSLSFFAAGLSLVLHPHNPMAPTVHLNYRYFETSDPKDPINGDKNWWFGGGTDLTPSYLFPEDAQHFHKTIKDACDRHDPTYYPKFKAWCDKYFYLPHRGECRGVGGIFFDDLDANFLQTSAGSSSNPQETLFSFVSDGLASFLPSYVPIIEKRKDMSYTPEQKQWQQLRRGRYVEFNLVYDRGTSFGLRTPNARVESILMSLPRTASWAYMDPVSGTRTESMPVDEEDLGEDKTSEKEIMDVLKHPRQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TUC9</accession>
    <name>A0A1Q5TUC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000615">
        <property type="protein sequence ID" value="OKP03803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TUC9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP03803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="55" mass="6596" checksum="EFF5160347B8B8D6" modified="2017-04-12" version="1">MYEIHSYQYTILQWVVLYGTSMFYNNWKAYPLNIGARETESLASADNRSYKFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U045</accession>
    <name>A0A1Q5U045_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_6560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U045"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U045"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07078">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP05840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="503" mass="53997" checksum="D8C57B3420E7F9E1" modified="2017-04-12" version="1">MAVAQRAAELLSSFPETSVYRWSCDDTSRRFAVENPATGKTITTIQAGNVETTNAAIEASQAAFVNWKSRAPQDRCSFLLRASDEVQKNAQELALLLCLENGKPFKDAIIDVFFLIQVFKYFGSIADKLPSEFFDQGNVYSTIIYEPLGVCAGIIPFNWPPIHVGGKLAPCLAAGNTMILKPGEQAPLTAIRIVEILQTIFPPDVVQVVPGLGPDVPQALVNHPLVKMVSFTGSSPVGAKVASAAGSSLTATALELGGKNAFVVFDDANLDTVVRDAVEGAYFNKGEACTASSRILVHRSLYQPFVDKMTAAVSKLQAGNGLDDATHVGPVVSQERKQQILAAIDLAKSQGARLAAQGIVSTDAEIADGFFVPPTLFADVTPEMAVAVEEIFGPVACVSAFDTEDEAVEIVNASRYGLFAGVYSTEFSRAMRVARRVEAGVVLVNNYFRGVLGTPFGGVKDSGHGREHWIGTLREWSQIKNIRYPSGLGAPLPQWRAIPEIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0D8</accession>
    <name>A0A1Q5U0D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000602">
        <property type="protein sequence ID" value="OKP05939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0D8"/>
    <dbReference type="OrthoDB" id="4175271at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP05939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="81" mass="8187" checksum="39B96B7D2CCED508" modified="2017-04-12" version="1">MAAVGGRCSNNWGADCICLDQDVCSGQYGGQPYTGSPGNYPCPSDPANVMACVINPCPNVGGDTGCRWNDPGVCGSVLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U0Q2</accession>
    <name>A0A1Q5U0Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_6542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000601">
        <property type="protein sequence ID" value="OKP06056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U0Q2"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP06056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26496" checksum="BC71E7DB31AF3426" modified="2017-04-12" version="1">MAVIGQADGAALETAVRNASYHLDEWHAALPEYMRDTPGNMARYASEGLGRTFVALHIGYYHYGQLLFYRFLQQDRHESVPNTHFYANKCKTYAANLCELLYTAKTNPNCEVLYSMVGHILVVSSTVQLYILLFGVDGEDVKIARIRLERNFEILQHLRTFWPTLDLCLLRLRAFHQACRVSMDTTFRLDQWMLRFLSEFAHPGDDKLSEATNPNSSRVENRDFRDFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1M0</accession>
    <name>A0A1Q5U1M0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP-2 complex subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1M0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U1M0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="1">
        <location>
            <begin position="184"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="218" mass="24619" checksum="A8FFBF340D0BAA88" modified="2017-04-12" version="1">MPVYMLHGFRWPRAGFTGIRVYIVLNNLEEAAAEYIQQPLTTELLTESFKKTQADLMPRLPELHFIEQYDPQDESSNTVSQDYAYVSAKVVTIPDGAGAGPGLEDVVEQGSGLSADATEALEALRDRLAPGEKIGWFMVYNGDPDRWYPPSEDEDEYEDEESYVDEKLESRTENQTEPGTPQSYTVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1Z7</accession>
    <name>A0A1Q5U1Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_6492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1Z7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013067150" evidence="7">
        <location>
            <begin position="29"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP06502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="519" mass="56279" checksum="F26B8976D547356A" modified="2017-04-12" version="1">MRLARKPHLIRSLVTLVQLTVSLIGASAKRILTERLRGIQKAGGDTKCSRFSVHQQYQEPSIDSITQWFLLFFLCLRPSFLQLLHLALISSQNRPLSTYQRELTTFHQIFAAGSRDQAMEKPNGAPGPAVALVVLRVLHGGMLAYAHPILKSLVNTSSTICSTGTQPYCVTFSYGPNYLSFVCSEKEGIEYQMEPYWKGFSDPIVFPVYTGSNGVSTGTQYPAGYPTPSSTTSSSSSSSTSTTSNSASSTSSATSNPSDHRGSSAPVGAIVGGVIGGLAFISLIAGAIVFFLLRRRQRPRPGQPQQLAPGFPQEPQPPNPAMNTGLPLNKTAPIIPVLGQGPPQSPPAQQPPRHEIETQYNKPELDISRQHPELAGSGQPARVPVMQPIQPEYVSVAQQPSEAELDSRSTGHQGKEENVYEAPLAAYIPTNRLEQGLVESLRRYQAPSIKEMLNKIEYDQYGLLFGPVSGALAGRLAFAIPLIAACHYERQKEKSSGGDADTCTPYFGRYQPGQCQIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U2K8</accession>
    <name>A0A1Q5U2K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinic acid utilization activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000589">
        <property type="protein sequence ID" value="OKP06720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U2K8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U2K8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000005">
        <property type="entry name" value="Quinic acid utilization activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP06720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="625" mass="69258" checksum="2F8718FA97BD67E1" modified="2017-04-12" version="1">MDNDGSRSQAAKRKRISRACDPCRSRKHRCDGQQPSCSACSSTQQSCSYDSSMKKRGLPTGYVRSLELLWALLFTVIPQSMRLVTQLIPDIRFALDSHTKLVMVSKFVKDPDILRQIWEDSGIQVALDNLLSNASDNFSADEISSSVESKPVSTVESLQFTVGSFEASQFQVADGGQQVSNPVLWLEGTNNSEGISQHHLSTAYTWPADRVALSSFPQNAQRLLDLYFARTHCWLPIVQKHKMYEILYSSSPPAQAGHLATFWAILACASLQDSCEPFGLPGVPDGYGVVLTPEQIFLQARQQIPNEEAQELGYVQALLILSLFKLDRGEVAKAWRLIGQAVRQILDLGTLPPKGYSSNAARCSSHDDQQARLLLSCFVLDTVVSCHLKKAPHLRTMDIRSLPMPAETGPDEWEPSVVCLGESEHRRPSSFMVKRQPLRAVSIFNHYVGIISILNDAISEPLVDVSDSAHAKHSSALCRWCDQLPEHCKFPLDSSQNHFEVAKGLSPQLFNLHLAFKSTEMLLEAQHASIPRSGQSSHPPPRASSSDLVVPYLPTPMDDEEFTLAGIKGTPLNSGRSSSCEAPEDTMNEHEKRIWKELFELVDADETNLSSFSIQGSIDHSKDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3A4</accession>
    <name>A0A1Q5U3A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3A4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U3A4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP06956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="105" mass="10477" checksum="FB0D3E7AFA88E859" modified="2017-04-12" version="1">MATMDMGFLPTIKCSNCGNNVEISAMGDHVCAPIDHGLPAPGVTTTSSTNHSTLGSSHASSNTTAPPSPPPSAGLDAPDQLTVAMAAKPGRPGAPPRIDPTIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4P2</accession>
    <name>A0A1Q5U4P2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_6019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4P2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4P2"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP07430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="292" mass="30344" checksum="A282F3D9CBFA74D4" modified="2017-04-12" version="1">MHGDQASPPHQFQLDEVDDENIWSPIQLAAAKGDLGEVKHLLAQATVNPNEAARGYYGKTALQAASCNGHLAVVEALLAAGADVNAAGGNNGGMTAVVLASGAGHIDIVHRLVSAAADMNRPPHQYMGRTALQAAAEGGHIELLQCLLEQGAEINAPAAKNNGRTALQAAASGGHDKIVEIMLDYEACVNAPAVRYKGLTALQGAALGGHDRIVRRLLEKGADANAQGSYYNGYTALAAAAEGGHYEIVQMLLDAGADVSATSGNKTRTAAQIASFRGQEEISQLLQRVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4Q6</accession>
    <name>A0A1Q5U4Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_6040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4Q6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4Q6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="331"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP07451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="57000" checksum="106DAB2D213DE647" modified="2017-04-12" version="1">MNPEISFGDSNSGLQIGINNGPLNTQQLHLTGDINIPHSVYKSLFNAPDLFTQVRDELGLLVSVLIATEEHAPKFRPDDPQLSELEDVLSGCYSVLQDLVRLKEHFDNVGAQTQVTWERMGWGGEELAEIRGKFSLHIQVLNFLNTRMLRSSHENVERMLEAFIGEIRSGKRESAAMSCVSTASLTVDEKEAWRMLRKELQSIGITPGLFTQHRRLILSTLQKFLTQGQVADFSRVFEAEETETASEAAVINTDSSVQTAYKKLTASDEESPTGRQLEIPVTASGTKQKKRLNIMTRLTSRMMRLTTGKSIDKEISKPFTAGLRYQFHGVCMVCLEDIEVPDSSGPASTNEHNILEDLPSNLIHWKFMDTPCGHTFHITCWKRRLEYPSRCPICYQTISLDNKSLDSSPCDNELNTQEQTQQTSVDKIYTKDPSTGRPVVLFNVVGLFDFNVDGDHLESGYPYLTYSQGELFSVIAEKEELWLAFHRNDAECKIGWLWKVQFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5W6</accession>
    <name>A0A1Q5U5W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5W6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="247" mass="27304" checksum="37F0197E2CA066AF" modified="2017-04-12" version="1">MTSFVPVPTGSDHWTWGSSQLFESSTPSDNDSEFNPERSDLSYFVAEIAMRKMLQRCTWSTSTLAQGSHVYAPIVAAELERQLDEWLQLLPQQLSFRPSSATRSRPGCDPSSAHVEFLRTQYYAFKASIYWPAVYEALTAGEANSDLLYHCAKFFTSFAEFVPSAVAAIAVCKPNLWTLCTSVFTISMAALAGVTEPCLVVVVPREAIHGLELASKAFDGTAEISPSLADMGAILKESIQRYHHSWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5Y9</accession>
    <name>A0A1Q5U5Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose permease MAL31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000578">
        <property type="protein sequence ID" value="OKP07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5Y9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5Y9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF15">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="426" mass="46535" checksum="D894C3230C62843C" modified="2017-04-12" version="1">MQGYDLVGGGQLAALPQFRKKFGILEANGSYLIPAHYLSAWSSIAPACEIVATFIFAPLLEKFGRKPGILVAAFISAGGILLQQLAGDWTVHLAGRGINVILVSGWLFFPESPYWLIRQGKTAQGRKSLKVVYGFRDESFYDAEINRMEAEIRVTRDIQGDIDARHRGRICGINFSAEAECFRGTNLKRTMTAIFAASAQQMIGATFVIGYATYFLELIGVNDYFNASVALYVVMLLASMAAFPLTEIIGRRTLIVGPQFALCAMLLLIGVMGCIPDRAKASWGIVAFIYVWAIIYQLSIGATGFVLASELATMRLRGATQGLVTISNAVWGLIMQFTIPYMINPDAGNLGGKVGFIFLATGLIAAVGGFFLYPETKGISFEKLDELFALKVKPRHFKQKAKETAHIVTGEVKLDTRSVHAEQIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U771</accession>
    <name>A0A1Q5U771_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_5687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000569">
        <property type="protein sequence ID" value="OKP08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U771"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP08320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="415" mass="45912" checksum="22718D67C85BCA14" modified="2017-04-12" version="1">MLDENKVRLRASCNACNESKVRCSQRKPTCSRCERNEIDCIYGLSRRTHKDAPPIMIPPPQRGRKTSRPGRPSRQPSSGDTRTSTSASSNSSNRIATQSNDCVTSDEPVEIHNSNTNILDDYMFQTSIETNPMHTTTQLLDFSSLVTGTTTGTGMIPGHFSMTDPTPTLGDLDTFFGTNHNNDVMDMGTFHGLHGQGECTCHAGVTELLASMRGASSSNDQRLSLDAQLARLKQCIVSSEESMGCIHSRDDSEPIHIMAVTMLIGYVIDDFKMLANESTVRRGSSFSSSSSVADFASLGNKSSVATPSSTTTSLGDIIEPRLSWGVFELEEDDEMDLRQRLYLLSFRKLERLLSQLTLHLRDQHNALASLPDPSRHMAFVIACDYARLWLERKAGDVKRLFSFHTTDEIMNSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9W6</accession>
    <name>A0A1Q5U9W6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000552">
        <property type="protein sequence ID" value="OKP09259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9W6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="72" mass="8090" checksum="6D99BCCA52C433F9" modified="2017-04-12" version="1">MPYLWLLPKARQLRGIGRMAEVPALLHTRRGIAKGLRNDMAGLGRLESTLKMVKFVELSQFPESIEDRGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAQ8</accession>
    <name>A0A1Q5UAQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000497">
        <property type="protein sequence ID" value="OKP09556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAQ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAQ8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30964" checksum="A7AFC1BBF770135B" modified="2017-04-12" version="1">MKTSNFRRWISDPLGRQRVDDNAFFEKDKDITSRSSSLDEESRGSTHDIADEQTHLDTSYTVASKIRLPPPAIIVKRTRRNNENGLKDNVPHGSVSSDTVCLEDVCTASECSDTLRGSETKSLQTIDECHGSGQSPSVGLLRLNVYRIEIEFIPRRDTQLGVKQGDKVVMTRVFDDGWVGWQSSSYLNKDQADRPLQAFCELLRTKKQGLVPRACLSVWPSRRNNTPPSVTSVQLVPPTANSHTNSRPTTPVSPISPILPSSPVFPRFYSSGSSTESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBE0</accession>
    <name>A0A1Q5UBE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000450">
        <property type="protein sequence ID" value="OKP09779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBE0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBE0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="552" mass="63134" checksum="DDC678CF55A9920D" modified="2017-04-12" version="1">MPEESVPKSSPEQRNANALLGVRRHSFYRSPVHFDAHSLLHFVDAQLDAAEDHMRALREDPRYFADMLRERKDHAMEHVAWSPSARPVQVKESWNHTIRVVIREAYAALGMWTAVKVQLQALSRLMADHGVGLEPHEALSQPLGDALANMVWLLELMFEMPFATFLEVLPPSPLMRDSFGKTITLDGKLQYLPTQQACEDTTKGGIIRTVAMLMNKDIRKDVGLPTLMDLFDTVLLKDQATVSLLSPLVMRTISDLSALAECVREIFAFQPWARNIRSALERKEASFRQDWEKAKARWLLPDKAWNQSDLATSGAPVEERFAYPVNQKPSRKRTNAMQRAEANLDKFWGEADREILDHLKQMELPFDATWVPYRTPNWVEPMSRREPRAPHVPQVSQDVIDFELAHRTQQRPSKSQTGNTQPEKAKTRGPAQAPSSEFPIPPPEDGTPTPKISVTHESLQVFRMLLPHRWEGALPGQLPWRDFMSAMTEAGFRSESTSGSSVGFIHYKTRQRIQVHSPHPHSKYEFHAARNIGRHLRRRFGWDEKTFCLKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBU2</accession>
    <name>A0A1Q5UBU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBU2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="89" mass="10239" checksum="962614244D93604A" modified="2017-04-12" version="1">MGRGHEACFELLLSHGADPTEVQLGESPEYLIQLVVESGRQSLVQISTRRGFALEIARRQQRIEKGPYFYPQVVEVWRSWKTFVKTDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBW1</accession>
    <name>A0A1Q5UBW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sphingoid long chain base kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_4652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000424">
        <property type="protein sequence ID" value="OKP09940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBW1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBW1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP09940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="343" mass="38221" checksum="25D24419A292B1A6" modified="2017-04-12" version="1">MTTMQKMKDMTEQAPLFDAAQCRVELHETRYSGHASRLVREDRDIDSWDAIVCCSGDGLPYEVINGIAQRDDAGNILRNVPVVQLPGDSGNAMCVNMFKTTSFSHAALYTLKGIRQPMDLMLVTQGDKRYFSFLSQNIGLLAECDLDTESLRFLGGKRFAVGFLQRLFKPPVYGCDLAVYNSTSQHSTDPHSDRLGSDINGENRHGLPGLQLGSLNDSLPDSWKREHHPTLGVFCAGQFPFVDAKSKVFPHARPDDGLVDIIIVDSGIGTWRLLQWLKRVPEGNHLAMREVHHRKVSAYRVVPVSTRGAFSIDGERSSFQPFQVEVHPQLGMTLVTPPGVEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC07</accession>
    <name>A0A1Q5UC07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000404">
        <property type="protein sequence ID" value="OKP10015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC07"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="192" mass="21693" checksum="BC32F4371D0EB21B" modified="2017-04-12" version="1" fragment="single">LVPRESTTNFDSLYKVLGQDHFFDKVVTKMMLEILSNRLCFRETIEDQNNRHRQNSSAKEQLVTVVPLEAYPEDTAAAEEYPEPEEVPVEAYSEDAVAAAEEYPEPEEVPVEAYPEDAVAAAEEYPEPEEVPVEAYPEDAAAAAEEYPEPEEVPVEAYPEDVVAEEVPALEKHATKLHLTPHLLENLYLYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCN2</accession>
    <name>A0A1Q5UCN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Hexose transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000379">
        <property type="protein sequence ID" value="OKP10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCN2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="589" mass="64153" checksum="26CB6C775303B1A0" modified="2017-04-12" version="1">MVAPLPGETAISAKRAELAGKGGILGLLSNKKTSAIGLFASLGGLVYGCKSSSPYYRRVGVYSLTGSITRQPGNVRAGLDHELVYQSRYAATTSIQQGMLTSILELGAWVGTLFNGYLADAAGRRLTVLIAVVVFCVGVIVQACTQNKDYVFAGRFVTGLGVGSLSMVVPLYNAELAPPEIRGSLVAVQQLAITFGIMVSFWIGYGTNYIGGTGDTQSNAAWLVPICIQILPAVILAAGMMLFMPQSPRHLMNTGRDEECLQTLARLRGTSTDDLLVRIEYLEIKSLHLFEKETAAEKYPQWQDGSFKSRFQIGLHDYMSLITNPSLFKRTTVACMIMVFQQWNGINAINYYAPFIFQDMELPGNTTTLLATGVVGIVEFLFTIPAVLWVDQIGRKKILIAGAAGMAICHFIVAGIIGAYQHEFGEHRAAGWTVIVFVWIFVINFAYSWGPVAWIVTSEVFPLSMRAKGVSIGGSSNWLNNFAVATATSPFLSQSALGAFIFFGCITTIGIFYVIFFVPETRGRTLEEMDELFGSSGMAAADTARKTRIEREIGLLALVGVEGPESEKKIEEVSHSEEYKREDEGVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UCS0</accession>
    <name>A0A1Q5UCS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000370">
        <property type="protein sequence ID" value="OKP10272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UCS0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP10272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="132" mass="15495" checksum="DE58FF1D0F81F35D" modified="2017-04-12" version="1">MRKTWPDIDVAKQKRAAVKLRLLRHLLQISLTSEVDQITPQTDWTETQDYSRPIETEVSSLQVTNKQLRLFQPRPQPHASKMKSSYNILTRVHRFMPPLYPTYPPLQKVDCALTRDRPLACYIARVTQLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD09</accession>
    <name>A0A1Q5UD09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease fcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_4214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000353">
        <property type="protein sequence ID" value="OKP10367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD09"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF16">
        <property type="entry name" value="PURINE-CYTOSINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP10367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="513" mass="56313" checksum="B2D9A2DE77C5DE2C" modified="2017-04-12" version="1">MKHDDIEKIHGSPSLHSMSQHELTTSSSNDPIKETILEPKPQTRLRRWITNVSNVEARGIEPVPLEEREPVTSSTSLHMMLLWFSMSLATNNIIVGSMGTLVLGLSFKDAAICAVLGNLVGTTTIGYMSTWGPRSGNRTLIVARYFMGYYPSKVCIALNILTNLGYSMVNSVTGGQILSRISGGHISVLVGIVVVAFSSWTMAMFGMRIFQIYERFAWLPQLMVLCVMLGSAGPHFDFTVHTPVSQGRLNAKRVTFFSLALSVALAWAPLAADYYVYYPPHVKRWRTFIVTVLGSAQAMVITLLLGIGLGTMMASSPAYLTKYGSTPGGLLMAAYDALGGFGKFCAVINVLALVTNNTPGAYSMGMNFQMLGGFFWRVPRPIFTTLATVIYTACAMGGRNSLYEVFKGFLPLIGYWVMIWLIIVIEEDVFFRRLKGYDWSAWNSPHRLPVGIAAGVSFLVGWAGAIIGMNQAYYSGLLAHVASGADLGLWTGAAFTAVVFPPLRAMELWYFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDZ6</accession>
    <name>A0A1Q5UDZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDZ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UDZ6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP10689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="251" mass="28370" checksum="1A812E0A1885BD95" modified="2017-04-12" version="1">MGILQFNVNVCRYTRSLEERIAELEAQLSQTHQIETSNSQQRVVIQSAPIDDSTVLDDVDRNPERNESEPVRNSVRLLDAELDSSHTHAFDEANLALETQHAQHLVVPSCTSTSGITFSSPLYTTGLITSSIPGDQCGHTSLLTSILATLTKGAPCGISPPGDRALSHVHLSPNIATQLLSPDHFIRLPKHVEDTLIKIYLERVNPRYPFLHVSTFLEWYETWKARPKEQPIPNQKYRWKDFFVTMVWSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UE06</accession>
    <name>A0A1Q5UE06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000313">
        <property type="protein sequence ID" value="OKP10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UE06"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012411797" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="34450" checksum="03D8F9A5F57E6E28" modified="2017-04-12" version="1">MLSGTILVSLIALGVVNVALAQTNITANVCADPSAFTSCIAQATTASKGCMDICNGNNICVLGCGCAMYQSYINCVAESCWNQVYSCEYDELIADYFVNCPAATEPVPFWPAPDNAPGGCSCNLGKVLHSVMKAEQGYNSCITNNTSTSIVQLSNKNTACGCCEVSAGLSAMYETCPDTIPSAMGADSWLKTATLYGELINWGTCGSVLDKYSCPNLGFAPPSSNSSTFYNPNNLPPNGTYTLYNTGGVNALTAPASGSVFTWSQTSVTYTVTASPWKNSAVKATAAGTSGGSVASGTAAAAGATKTSGGASLSLQLPSVVVWLSVLGVLAKMVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEJ6</accession>
    <name>A0A1Q5UEJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_3718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEJ6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEJ6"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="384" mass="42359" checksum="D7A8FE0172248DBC" modified="2017-04-12" version="1">MAENVEAWTLLSLALTTILVRISVRWKLVGPANFQLDDYLMPLAGIFFTLETVAAYLVGAEFEGLTNSYMTPEQRASLSPDSKEWSNRVAGSKIQVIGWSLYVAILWLVKLALTVFYSRLTTGLQHLPTRVRLAYIILSVTYLATELSLLLSCQPFHSFWQINPDPGKLCQPTNSPVYVFVVMVLNVVTDLYLLSIPLPLLWQVKIGLRRKIPLMALFSGAAFVIAAAIIRAIMVTTSGPEGAIAGSKWACRETFVSVVVSNLPIIQPLIRKGFKKIGLSQLFSSSGKPSGQTYPLSSRGLQTLTSRAERSTKKSKGDAGPTHTQVSAWGSDEHILTDPEPTSKDITVVSETIVHSEPWATEERQRKDHAGTSPKEWDSRLSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG68</accession>
    <name>A0A1Q5UG68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS maltose permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG68"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG68"/>
    <dbReference type="OrthoDB" id="5408102at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="64997" checksum="E15C7C5FEDB16804" modified="2017-04-12" version="1">MLPPRAALGRIPGHLRPVLPLRTPGPKVRLQPFTHRSRLLLSPPPGRPQLPFLSPLTPIRSLPPLSIHLRQHFGRLISTESRAHFKKRLSRGLKIGLSFYAILVLFQIIKLGLYQEDIEHEWPTPAEWSWKSRWCLRSAQAIMHPEHIGKLMTNWPMVAGYLRELLERLENTDGEGKGIVEQEEGGLLVEGVGKTGLDVSAKSEHWRRGYFQALMGAAKAAENLDGWLTDRKQKISAPAEYVVGPSNPRPKPMPAGQKKVPQEEDCEAASPPPETFYMKVLTTKGFDTRQKLDAALAYADWLDYKGLGRTAGDMYTWALDIAAGGLEGDANKVVDLETGILKNNGSDLPSENILRVSTALAVHNARQGNLPTALSLFTSVLKARRSLPTTPFFNHTSPLSLPSQTHASNDPITGFVTSLKKIFNPPEYPPALPSGNTPPLRTPSSTCDEAGLMTYIGEILYASSSRDHGLAWTRDAVEIAESTMLQLTSPEDKPARARCAQCLKVGLENWKAMVSTRVAQAKKEQAEGKGAGKSKSWFGSRGSSQSAKVEEVKRWEAEEALLEDRIRRLFPVLVGESGLDSLSPNSSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGH8</accession>
    <name>A0A1Q5UGH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrosoguanidine resistance protein SNG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGH8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGH8"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="33"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="510" mass="56837" checksum="F38BC6A5E2F01EAE" modified="2017-04-12" version="1">MGFYSKARLPRPSIHDPAVRSRRLAVIKAAGINLLILQFLFLGLFCYIFGSLFQQTTHTHNINILFVDYDGSVIGTAVRNAYAELKGPGFPTLDERPALAYPNPDTIDSAVCNIKFWGALYITTNSSNDLTAALAGGTAASSYNGSDVLTMVWNEARYPTTVDSAIYDKLTTLSEAARVVYMKSNGKQTIQALNSSDDAALAIYANPWTLSSINLQPTSQGSRLIYNTLVIILIMIQEFFYLGYVNGLYLNFNLYASVTPHRIAIVRQIISGVYTLIGSLCTTGAIWAFRNGWNVHGGQFMLTWMALWLFAHLNFLVLDAFTVWVSPPFVPMCLISWMMLNVTSILLPFELSPAFYKWGYALPAHSIFNVLIDIWSGGCNPQLNYALPVLFAYEIIGLVLSSIGVYRRAHYAVIKQEKDQKDLQERIAPAIAEREGQRLERAETTLEDQESRVSESDREEGGRGRRGTVATIKDEGEVMDIIRREMSRPTAETSTSRTNNGPCFDLPFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGI0</accession>
    <name>A0A1Q5UGI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000276">
        <property type="protein sequence ID" value="OKP11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGI0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGI0"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="370" mass="43113" checksum="69FBCA5F63C72DE4" modified="2017-04-12" version="1">MAHNDIYCGLCGAALSIPLFSATDAPDESGPGNGRPRIEDMAWLEDVRMLHQTNHETTNFESANLSSIVTRRDDDGWWDRTGYVPALDDFENTTPDAFKVFDPYMEGRYHIIPLHDACNKVLAKFLNYSVGTTPKDYLRVLFEALRSFHDTSSDFYAGKIKYGKISKQHGQFWYPTLTTKAFVYDPFFTSPVLKTYYDNLPEIGKDGDEREDSAVCYMKTTSKPDPFRKLPPELLMMILMHLPAQSIRQLKLASIAIVQLQLPDSFWKQKLKRDMPWLWDFPGQGTEQTRKDLDWLQIYKDIYIGSKGNGKSPFFNLTNRNRIWRISEQIAPRFVKCQDEWKIAQEREREKLPALTSEKERRLWPRLDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGM3</accession>
    <name>A0A1Q5UGM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000275">
        <property type="protein sequence ID" value="OKP11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGM3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGM3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="28"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="504" mass="53730" checksum="C1AAAAB77EA6B7B0" modified="2017-04-12" version="1">MSSLTIVGVEGRQVIVPSGLFIHNEFVPSVTGQTLRVENPSTGEELGTISAAGKEDIDKAVESAKAGLQAWKAVPGPAKGRFLLKVADLIERDAQDLASLEAVDAGVLYTDSMGMNIPQALGCLRYYAGWADKIDGKVLDMEGGIAYTHREPLGVCAAIVPWNAPLQVTFPFSLKMITIWKLAPALATGNALIIKSSEMSPLYAQRLAQLVKEAGIPAGVVNIVTGEGASAGQALSEHREVRKVAFTGSAVAGRKILQAASRTNLKKVSLELGGKGPSIVFDDCDLGNALLWTRIGITANNGQICAAGSRIYVQESIYDRFVEAYQRAAANAPSIAGNPLDAATTKGPVVNYAQHQKILDYIRQGKESGARLLFGGERIGHKGYFVQNTAFADVADNATIMREEIFGPVASIAKFSTEEEVIAKANDSHHGLSAAIFTNDINRAHRVTRAIESGQVTVNAWAMLSPNVPFGGVKESGFGRDMGEDAMEGWTTVKAVKYHILPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGR0</accession>
    <name>A0A1Q5UGR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease MAL61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_2716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGR0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="575" mass="64259" checksum="45886271EFC2D3BB" modified="2017-04-12" version="1">MAESKVQDTIAPAEVAPRYPSDGQEGHEGWTSDSSMKTIIQNAKAATEKEQSMSLLQGIKLYPKAVMWSVIISTCIAMEGYDISLVNNFYAFDQFNRKYGEQLPDGKYQVPARWQSGLSNGAYVGEIIGLFINGWASERFGYRYTIMACLVLVSAWTAIFFTAKNVQSLLAAEILCGVPWGVFQTLTITYASEVCPVALRGYLTTYVNFCWGLGQLIGIGVIKGMLNRDDQWAYRIPYGLQWMWPLPLFIGIFLAPESPWWLVRRGRTKDAKQALERLTSKDRDTDFDADETISMMVHTTALEAKITKGASYLDCFKGTDLRRTEIVCMVWAIQNLSGNSFSNYSTYFLEQAGLDSSNAYNFAMGQYGINMVGVFGAWFLMTLGIGRRTLCLYGLCGLCAMLLVMGFLGLVPDSHRDQASMATGALMLVWALFYQLTVGTVCYSLVAELSTRRLQIKTVVLGRCLYNVVGIICGVLTPYMLNPGEWDWGNYAGFFWGGICFLCIIYTYFRVPEPRGRSFAELDMLFERGVSARNFATTEVNVFDESIEGRVVDDYRAQKNATNDPSQVEKDAGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHE0</accession>
    <name>A0A1Q5UHE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHE0"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7412" checksum="3C86FF2062D77133" modified="2017-04-12" version="1">MFEAIRKLDTRGSFSKGLSEVENYLASTDQLLWSEENYLSFDCVDPLKSRLKLYVAEQVTSYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHI1</accession>
    <name>A0A1Q5UHI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHI1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="53" mass="5771" checksum="12F458C54BC74653" modified="2017-04-12" version="1">MLKNTYVVHDDNFSGTEKLLRDYDATKRIASTTACIANDMGIALFETEGSGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHW9</accession>
    <name>A0A1Q5UHW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_2411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHW9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51326" checksum="7F328B16B8FC53F5" modified="2017-04-12" version="1">MEEGKSTLKRASSAPSIAQTFSPCREALFITIVCMGQFMTQTNVGVCLSNIDILGASFGVTDSGILSWFIAGYSLTRVLESYLVHSRAGSAGIGAAMLLPNGLAILGATYPPGKKKAMIFALFGAVAPNSAVLGAVFSAVFSELAWWPWTFWTQAIVAVVCAGLGLLVVPSIHHETSPDTSTWINLFKALDAPGAFCGIGGLVLANIAWNQAPVAGWSTPYVYVLLIIGLLLIAGFFVVEFRFAEHPLIPFHAFSRDVSFVLGCIACGWGAFGTWIWYFWRFQMEYRHTSPLLGSAEFVPAAPIGIIACFVTGLLIARVRPGWIMVMSMTAFTLGNIFTAIAPVDQTYWALTFVCLLVIPWGMDMSFPAATLMLSNSVERKHQGIAASLVTTVVNYSISLSLGFAGTVEVHVNNGGKTPEDVLKGYRGALYFATGLGGFGILLSVVFTIKCYWEEHQSRAVDNAAAEETSLSTIAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UIV6</accession>
    <name>A0A1Q5UIV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_2152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000228">
        <property type="protein sequence ID" value="OKP12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UIV6"/>
    <dbReference type="OrthoDB" id="2157354at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="128" mass="14141" checksum="5655044BF959ECD6" modified="2017-04-12" version="1">MIKLLLDNGPDVTATNGQGYTALSVAVKQQENIIVNELLLRGAYPLVGKRSAVHAAIKSEDLDILKELLKNLSARGKCDNKLELSAAWIKEGYSYLACHVPRKPSSGIFLILKELVAHHRRHKYPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJ63</accession>
    <name>A0A1Q5UJ63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea active transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_1876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJ63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJ63"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="73593" checksum="7C52D26CD76D10E7" modified="2017-04-12" version="1">MSEGTVTFEAPLSQGFGYGIILGLGFAFALVMIFITWALKRYQNEVQTSEMFSTAGRSVKSGLVAAAVVSSWTWAATLLQSSAVAYQYGISGPFFYASGATVQILLFATIAIELKRRAPNAHTFLEVIRARYGTTVHVVFIVFCLMTNILVTAMLLTGGSAVMTSLTGVPTAAACFLLPIGVVLYTLFGGIKATFITDYMHTVVILVVIFLFAFSAYATNAELGSPSKMYDALVAAAKAHPVEGNAEGSYLTMRSKEGGIFWIINLIGNFGTVFLDNGYYNKAIAASPVHAFPGYVIGGLCWFAIPWLCASTMGISALALEGSQRMSSSDVSAGLVLPFAAVKLLGYSGAVATTLMIFMAVTSAFSAQLIAVSSIFTYDIYQAYIEPSAKGKKLVWISHMSCVVWAIVMASFATGLYYAGIGMGYLYLLMGVIISSAVFPGAMTLLWKGQNWIAAAASPPLGLAVSLIAWLVTAKKEYGILTVETTGANYPMLAGNVAALLSPLIFVPVLTFVFGSQNYDYESMRAIRKVDDTEVAAAAHIDLELVPGEGHGPSATETEEEERKLNRAALYSRTLTIFMTFALLILWPIPMYGTSYVFSKKFFTGWVVVGLLWLFCTLFGVVVFPLYEGRESIVRVVRMMSLDLMGRKPTMYRGQKTDGAQASGIATPTEKVGEKDKEALDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJC2</accession>
    <name>A0A1Q5UJC2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_1895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000205">
        <property type="protein sequence ID" value="OKP12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJC2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJC2"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="101"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="288" mass="31587" checksum="28DB951CE5FE2FE6" modified="2017-04-12" version="1">MTTKHDSEATVAVNIEELRNSKDAVIMRLMALQSYIADLSKAYVEHVNNVINGGPATIDIPAMPTGLTYHVESTRAASPSVKAEAGGVKKRKRAPVDPNAPKRALTPYFLYMQQNRTKIAEDLGGSAKPKDVADEGTRRWQTMDPKEKDIYKAKYLENYEAYKLDMAAYKAGRKAGDDDAANDQLQQSIAVIENAESESSDSETSESEEEEVEEESPSPPQPVKQKTPPKSAGAKRRRSDVKAVKEVAESPVKASPVKKTRKAAAEPASVKSTPAESKRRTKKRKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJD3</accession>
    <name>A0A1Q5UJD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000199">
        <property type="protein sequence ID" value="OKP12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJD3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="58" mass="6970" checksum="E6817775E3801F59" modified="2017-04-12" version="1">MSWYALWERNELAALTDPDQAFGSNTGTYMKYPEAHLRLLWYDMQKRDFGELCEYQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJD7</accession>
    <name>A0A1Q5UJD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000183">
        <property type="protein sequence ID" value="OKP12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJD7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJD7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="52986" checksum="7362AECD729D3779" modified="2017-04-12" version="1">MAIVKKIKEPTAAAKVAAGHAGATPEDPIDALIIGAGPSGMVCLRNLLRDQPPLSAIIVERQSVPGGIWTGHIPEYSTLQDLVCEYEVHGVKFPRREPQRRATRDQVAEFCDAYFKEFDLHDHVIWEHDVAHVEMVKPMLHKVDIRPFIKGNEATPVQNVYTRSVLVCTGHNMEPYMPKFPGQETAKFPIKHNNNIRDATEMPDSDILVIGAGPSAMDIIQEACVTQGAKNVHLVARSPHWGAPDLWWPWLWQFGWTELHLMRVLYRRLPIFVVDAIFWLIHLAWAVFHGVPEWRPPTHEGPSAKVGLILRSHLVKPYHNGQFRIHDKCGIQEIDGDKVVLTNGTALYPRMLVAATGWSTESSYLPEGSPAGEYDSLAAADAPRPLYLRFYDQDYPGIFYISVSAGFITYTESASFLSQAIGQILRGTWTPPSEEEIKKNLKEVVLHHICLPGLIEEDLAAAGFKDLRGKNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UJW4</accession>
    <name>A0A1Q5UJW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_1482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UJW4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UJW4"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="406" mass="44768" checksum="BB87A4A807AEA8E9" modified="2017-04-12" version="1">MASPAVSVVCVGMAGSGKTTFMQRINSHLHSKKTVPYVMNLDPAVHSVPFESNIDIRDSINYKEVMKQYNLGPNGGILTSLNLFATKVDQIIALLEKRTAPNTENPSAKPVEHILVDTPGQIEVFVWSASGSIFLETLASSFPTVIAYIIDTPRASSTSTFMSNMLYACSILYKTKLPMILVFNKTDVRDAEFAKEWMTDFDKFQAALREEEEAGAFGGEGGAGGFGAGSGYMGSLLNSMSLMLEEFYRHLSVVGVSSMTGDGVDEFFEAVETKRQEFERDYKPELERKRKEREEQKSSQRELELGKLMKDMSVSGSAGKDRKGPETGPETVSEAEDEEEDEIIKRGLADGEDFSDGDYEYDYRPSAGDDEGLSERYKQALSGSQSVPSEADSSFARYLRASNVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UK06</accession>
    <name>A0A1Q5UK06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cutinase transcription factor 1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000177">
        <property type="protein sequence ID" value="OKP12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UK06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UK06"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="166" mass="19564" checksum="C04DA1B2179AD800" modified="2017-04-12" version="1">MGVSERRLRKRIWWTLFTRDRSLAAAFGHPVNINFEDADVEDLNESDLIEDEDESFQGHDPQFFVKYVELSKIMQKITSMQRSPVDTLDIQAARIAQCEIELHEWLVKMALRLLRIVSEVWPMATRIAEFADCVLNDQYFHQLFVERMTEYRRLEFAAGMSNMDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKD9</accession>
    <name>A0A1Q5UKD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000166">
        <property type="protein sequence ID" value="OKP12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKD9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UKD9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="309" mass="35461" checksum="E26D321864AAD689" modified="2017-04-12" version="1">MSAMIIQLSQVVGALREEAGLLWKYVAFVVFIYLLLPKPAYKTNVKVPTVKFMSPWLPGIISRRLIPKIISELDYAFDVEFPKCDSTPITGYAADRFVAINSYEVFLRLVARVGARIFIGDELCREEKWLEASIDYTKNIFLTIALLRPLPGFLHPIVGRILPSSRSLDRQLIYIKEELLGPLINKRRTMEAASDPNYEKPDDFLQWMMDLAKTEKESHPHNLAQRLLGITSMAVVHTSAMSMTHILYDLLVMPQWVQPLQDEIRTEVPDWNNITQANLNNLRVMDSFLKESQRFNPPGEREWLPSLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKJ3</accession>
    <name>A0A1Q5UKJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKJ3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="271" mass="30177" checksum="A57BB245CF07926F" modified="2017-04-12" version="1">MANLISLNAHDALLEPLPDLKVSAKHTISSALHPVDFTGDMRPWLNFPAEVLNTYNTQTWSQQAIDARFTGLNAASSTTEEHVVVSCETDVQGRFLGRAGQVLGAVFKDQRLDLTFSSFKGAKLPHEGYRKFPDFVVMHPSGEAKVVGEAKVPWVPQHSLSDAISLFDSHAEENFRHLLGQIATYMLETEIKHGFLTTYDETVFLRKVDVNRQWVLEYSPVIFNDNQGSSMGTTGVSLSQCLYHIALVGLGDTYFGVNMGTRNQDWTIVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKZ2</accession>
    <name>A0A1Q5UKZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_1256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UKZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="173" mass="19417" checksum="3CA6CEE8EC8B0C18" modified="2017-04-12" version="1">MFSAHYLGLMREAWNLCLKEHCADKYHFKPESSRLLDEDPYQAGYNYGSLHTQQANQPDPEYVRREREALDAICQRTSDSVIDIWSLQPQPHLQPQATLPGPISAANSPTPSRENAALTVSTTDKDTKRPTSGNTAPKHWGEVVVNTNKKRSRPDLKDDGNATRDVFGVLKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL01</accession>
    <name>A0A1Q5UL01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL01"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL01"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="145" mass="16903" checksum="A071F85F32D4D79E" modified="2017-04-12" version="1">MPRGNPIKGNALARFKRELLRVYDVLEIRLSGRYGGGAREYLAGRGKGKYSIADINAWAWIRNIRRIGFSEEELDRLPHLQQWVDRIAARPAVERGLGEWYDEDKLNKCRGPDKRSLSYFTYNPHPAYSVICPKYYVDFMSFLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL22</accession>
    <name>A0A1Q5UL22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL22"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22977" checksum="842995D048471093" modified="2017-04-12" version="1">MPITEFALLRLKEKEPSPTTRSNLRDVIKEQSAWSKHPVNFVRQIEDPSLVYLLGGWASVAEHFGDWITSEPNQRLLAQLKGSIGIEWLFHLDIDPSLNSIPLNAPVLGISRYFVEASKKDEFDSIFKAGAPHLGEYTAPYSYAGGWRIDKEGEDEEFVLFSGWNKVEDHFGFADSDAFNEFGKIKGAIKGAEINHVHLEKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULL0</accession>
    <name>A0A1Q5ULL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_977</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000130">
        <property type="protein sequence ID" value="OKP13375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULL0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULL0"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="75"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="174"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="322"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP13375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="413" mass="44148" checksum="010E30D176DF519B" modified="2017-04-12" version="1">MSTGISDHAQLDSVFPTQPRQHSHSPESAPQPISPMSGIAQTKSSIAGGASSQITYNAGVDSQKSGGAVKTRSVDYILRSGLAGGLAGCAAKTVVAPLDRVKILFQASNPQFAKYTGSWTGLAAAIRDIKRYEGARGLFKGHSATLLRIFPYAAIKFLAYEQIRAFMIPSHDKETAIRRLISGSLAGITSVFFTYPLELVRVRLAFETKQSSRSSLTDICRQIYNERVLPPTTGAATSTASATAATAETVASTVNQAVPRSGVANFYRGFGPTILGMLPYAGVSFLTHDTVGDWLRSPAVAQYTTIPASESKPKKGSRQPQLTAAAELFSGAVAGVVSQTSSYPLEVIRRRMQVGGAVGGGQRLGIIETGRKIWLERGFRGFWVGLTIGYIKVVPMAATAFFVYERLKWSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULV2</accession>
    <name>A0A1Q5ULV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multiple myeloma tumor-associated protein 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULV2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP13447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="244" mass="29457" checksum="52C970D7FE2A3CA2" modified="2017-04-12" version="1">MDLVAGVRKEGSRGGRGEFKWSDVKNSTHRENYLGHSVMAPVGRWQQNRDLSWYAKGDADSEEERARQQREELQRVKDAEEEAMARALGLPIPPKAEENANLTPLGGLAKTPVDQEEAGAKESERESRRSRGQRRDRSRSPRRERRSDRSDDRGRDRERRHRRHKDDADRDRERDHDRDRHHRSHRHRSRDRDHHRRRSRSRSRGQNFRREEPRPRRVERSHSPAERRREPERRRDREDRDRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM08</accession>
    <name>A0A1Q5UM08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Endo-xylogalacturonan hydrolase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_698</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM08"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM08"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011959656" evidence="15">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="403" mass="41195" checksum="BCBF2C25A596C67B" modified="2017-04-12" version="1">MTPTIPRKLLLLLALPLALAIPDPSPILNARASTCTPVAGGSSSIDDVPAIRSAIASCSSGTIVIPSGTTYYLNSVLDFAGCSGCDFQVEGLLKFASSTSYWSGKTAMINVKNINGLKIRSLTGKGVIDGNGQDAWDLFASDSSYARPTLLYITGGSDITISNLRQKNPPNVFNSVKGGTTNIAFTSLTMDATSKSTNLPKNTDGFDIGTSTNVLINNVKITNDDDCVAFKPGANYVTVTDITCIGSHGLSVGSLGKSSSDTVKNIYVSGATMINSTKAAGIKTYPSGGSHGQSTVSNVTWTGVVVQGCDYAIQIQSCYGEDASYCAEYPGDANLSGIVFDGFSGTTSGKYGSVTGNLDCGADGTCGVKVSSYTVKAANGGTEVLCANTPSSLGVTCTSGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMT1</accession>
    <name>A0A1Q5UMT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMT1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMT1"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase assembly factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="184" mass="20739" checksum="E430B0C405AF3BDA" modified="2017-04-12" version="1">MSNTADHDQQSCLGTAEPAGATIASISSRITTTYQQPIQAVPSHNAPIRVPEYPKIPIKLPQTTTHIYNMGWLPWSSGDSNKASDGGRIAPDRTSRARCWEGRDAFFACLDRNDILDGIKDDKEARRKCAKEVAEFEAACSATWVKYFKEKRVMEYNRDKTIERIKKEDAETVKELKSQGWKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN88</accession>
    <name>A0A1Q5UN88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000121">
        <property type="protein sequence ID" value="OKP13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN88"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="75" mass="8488" checksum="5931905E281DD3B1" modified="2017-04-12" version="1">MELPGSHARLRKVIYQSQLRYDLNDLNIKGFHFANAEKDTYRDMDARLGSRVNIHPVCSVAPVIDCAICGEVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNJ7</accession>
    <name>A0A1Q5UNJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNJ7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNJ7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP14058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="205" mass="21362" checksum="2F8A7835B3C71160" modified="2017-04-12" version="1">MPIWDNLSGRKETAAPSPYDSSNAQDASSFLSEVAIPDPSRLHPLAGLNQDTLDYLTLDDSALDSLPGSRSVLPSRGWSDDLCYGAGTTYLAALTVGGAWGLAEGLRKTPVTAPPKIRLNGVLNSITRRGPFLGNSAGVVAMVYNGFNSAIGYARGKHDSANSVVAGALSGMLFKSTRGVKPMMISGGIVASIAGAWAVTRKAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNJ8</accession>
    <name>A0A1Q5UNJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UNJ8"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="261"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="692"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="930"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1639" mass="180970" checksum="D63212D914A45AF4" modified="2017-04-12" version="1">MDDIAQNVQFLSEKTLQDIAKGQLVKLALNCDDNQKVNRVWQSLIQTVSTPSLSNQHTAAACNAVSAFLDAAATSKVEKTKQLALSTENWLIVFEVFLSRYEDAKPKPLKQLLGSLINLLAKYIHGPKKDDIQKAVTDAIIPSIVLGEPRSRLKASLVCFELAIRKGAISGSDFISLLRKWLGESQQKWVHVFENAQEALSPINSEELSSDPSKELAAKVFVLGLLTQTNSRDLSGACGNVLGALLQKLKSESSEWSVSTIWVAPVRYMMLHIVDNLEAMSTQILQPIFSADPSGFMAFVESLPLKSLLTGDMTDAEDKEYILLFAALQIGKKTNLVHEDYDGSKPSESKKGTPQKLVLKSEVLGNFLLHREPNIRIAALSLLVTAFSTIKPFTSAATDSILRGLPSMHADSDSYSRGEIMSLTRKLIVRLKSGILKQQYSTEAASQATSGLPSGLVKSDDVTMAFLRKYIDLIAGDLVVTASYPRHISALKALKLLLESNLDPRTNIPPAKSEVETRWKSHMNVFEPRLLRLLVDLLLDPFEEVRQTSLLIINFFPQDILIGGFEAAADHSPAVCMRLTDALTRAELTASNTSRADHADTVARLYHILFCAALSTSSSAAGSDWWSTKTSVVNSILTKLEERLSSSKGLFNSTLREAPLHGYMSGLRYIVLMPDFHALLLNGPDVGAWRSIHDRIVSICDRVWEEVKPVLCIDSPEGHTDDPIEDLAVGPKDILSYSWRALRESSLLLHATMFNTTYGPYGPDGLKLADFEKVGRASFTQLAELRHRGAFSTVSQTFATCCERCSSSKDASIQELPKGWYKEARATIFESASKLTRRSAGLPALVTGILCSLHRTPFFKEAIDDLHEISRLPVEYNKEQQYLELPQVHAMNCLKDIFTNTKLGPFTEPFIMPALTLSAERLGSPIWALRNSGLMLFRALLTRMCRMVPGAVAGFGGVSGSEPGSKISFPKYPGLLELLSKLLAPTEGTTAQEGTDIVTERIFPALELIGEKVPTIGDDYDTKLCSLVLAHFQSPVWGIREHAARVYASLLTRTNILKDVEYLVNLVQENVSENYIHSIALCVRYSLRRFAASTDAFWTSHLDDLLATLRDVLAKLFAAAKSPSVAACLIETLNDTLERSIAAQAEDRIGSFVNEIYNEHDLHGVLGHAFDASQAGWNLASRTRASALLRRALAWCTLLKMLISQEWTGIPAFYHSISQFDADAGSWILEQLPENFAEFINYRKPLVNLYSSIIQGAHPVDSKTLAASNLATVLEEMLDSSPDVISEFNLPYDELAKSFKPESDIKQWNRHATDAELRLLGCLLALRASSIQDRSVPSVKNDIQRWVIKLRSALREETEFTTRYAAVASVQSFSKALRPQGGSARADAVLLDVYLVLYDMLNDDDEELRDIAATSASWVLSYSSVSPTSALALGPLNGSKLLATLITDHYSDSVYFARRVIRYLTGQESRISGSDNQSSLVPVSVLMAQHCQESTVLFVEEKQNLFIDEVHEVDVWSRVLLQLKRNAYPDTLIRQISSWVSEGLDHLLVLVNQDSGSDGLLGWTSKPESFTLGVRVISIAAALTSESFNVPEALDVEQVALRRQIQDLLDAGQKASLHDDWLSRMRVVLKSGGATGQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UP60</accession>
    <name>A0A1Q5UP60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_30</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000104">
        <property type="protein sequence ID" value="OKP14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UP60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UP60"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="854" mass="94047" checksum="10CBE92A9EA9610F" modified="2017-04-12" version="1">MKFSHSIQFNAVPDWSSNYIAYSNLKKLIYTLEKQVNRPDGQTGADVESAPLLGSSQVNNPDGIFKRALDTELDKICTFYQQKQAEIFQSTDELMHEAMGYLSETAGVNMDPVSETVIKARRLSSGSRRGTGSVFRNYGNGQRRRSSVISEDDVDSDDEHAHPAALGLRQRTSTDGGSTTDDAHAGDMADSTFWGQASSRLRRDSDLSDQAFLALYNAGVSLKKRLIESYVSLCELRSFIELNRTGFSKALKKYDKTLFRNMRRDYLATVVHPAIPFTDLTMAAVDNHIEKVEGMYADVVTKGNRELASRELRLHLREHVVWERNTVWREMIEIERRAQAANVGIRRTLLGGDEDPATARRQGDKQEIRTQEFATPLGRIHFPLWLCSLSFGTLVFSLAVFGAMLSVPIMESVEQQNCLAMLVLVSILWATEAIPLFVTSLLIPFLVVVLGILRSDDKPHKRLGPKEATSMVFASMWTPVIMLLLGGFTIAAALSKYDIARRMAMFVLSKAGSKPKVVLLTNMFVSMFLSMWISNVASPVLCYSIIQPLLRNLSPDSDFAKALVLGIALAANVGGAASPIASPQNIIALQNMFPSISWGTWFFISLPVCIISIFLIWGLLLVTFNPGRNATVIPFRPVKDRFTGIQYFISAVTLVTIALWCASHQLEHIFGDMGVIAIIPLVLFFGTGILNKEDFNNFLWTIIILAAGGLCLGKAVTSSGLLHTIASGITAKVEHLSLYSVLLVFSALILVIATFISHTVAALIILPLVRQIGVGMENPHPNLLVMASALMCSVAMALPTSGFPNMTAIMTEVPQTGQRYLQVRHFLTRGIPASLMSFVVIVTLGYGLMYIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPA0</accession>
    <name>A0A1Q5UPA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_14084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPA0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPA0"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="55"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="313" mass="33932" checksum="5BF4FF6D2EA7D794" modified="2017-04-12" version="1">MSETIKSVTIPNIAWDIAADIHFPPNFDEKKKYPAVVSAHPIGSCKEQTSGNVYGKAMAEAGFVVVAFDASFQGGSGGKPRFVENPEFRVSDFRYVVDYIQTLRYVDAERIGVLGICGGGGYAFNAAMTDYRFKCCVGITPANFGRLVRESFGGFDPAGSLEKMAKQRTLEAQGADRFVIDFLPPSVDEAKKMTTDPDTIEATEYYKTDRGKAPCGATSGLFSFNSAALAWDAFNHAEVLMTRPFIAVVGGVPGGFGAYRDAHEIHGRAGSKEKEIVVLPGVSHYMLYDEPKAVKAALDRVLPFLNKHLGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ63</accession>
    <name>A0A1Q5UQ63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13958</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ63"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ63"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="496" mass="56390" checksum="94FF53207FE3811C" modified="2017-04-12" version="1">MTRSQVPFPSPATLKRFPHIHDDPSSLSHALDPFTITTSTGFLPYQTAPTELPEVFKALASLVERLPVVKLDGTPGLLATYELGPATEAELTDLTDEVEKLKLPNGEWDRFTIAAVFRDYTFLASSYLLEPCWENWCKNPDQGYGLGRELLPKSVARPMYRCAEILDLPPFMSYAASYALFNYTLADHSKGLEEYSNLRLVRAFERGLDPKSSEAGFILTHVDMVKETGSLIAGALKVIDTLEQHGPRPDINDGFREILKAMEKIEASMEDMWGNSKPAEYLSFRVFIFGITNQSMFPNGVIYDGCEDNKPLSFRGESGANDSIIPLLDHLCQIPMPSTPLTKILHEFRAYRPLPHREFLTYVREKAEEIGVQEYSVQDSETAVLFLRTLNHVRSFRWRHWLFAREYIIRRTPHPTATGGSPIVTWLPNQLSAVMELMISIYDRYLAPKEGVTIVNGQEDLIASHRKQVEPMMELVRDQKEKLAKEVERWCQERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ98</accession>
    <name>A0A1Q5UQ98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ98"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="277" mass="31060" checksum="20BCC30656100E5D" modified="2017-04-12" version="1">MSTGTPRYFSPKRRREPSESDYYSPSASPTSTVSVVSLQESRIRDDTEPGQHSPRAVVAGRFKDLAIRGEHFPDRRGSNRDLQQPQTLQSEQATCISDSHDRGSMNLAEPLQAHSGEPSDAQNHHTGSESATYRMPDNALVTHICTPSKKRSTLSPYKGSDASPSKGRKRLSPPPSDVPLDDPFTWHDHEITGHNPTDPTDDGYGINGVGFKPTAAIAWARSQKRQRQVAEWKSREAREAREKRRERRNESSGMDRLRSIHEGAVQKRVKFNVQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UR20</accession>
    <name>A0A1Q5UR20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_5064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000050">
        <property type="protein sequence ID" value="OKP14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UR20"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="313" mass="34241" checksum="FFE2989DBA4751D6" modified="2017-04-12" version="1">MIFTRIGYRLLLAIEAVPAGVGALTPLLLPESPHYFVKHGSLTKATAAYTRLLSKEKAEPPVYRLTRALEHERDVQESAEAPSFKECFHGANWGRTRIIWYANMLQSFVGIAMIQNAAYFLELGGMSAQNSLNVTTASLCLLLPAVLLSWYLMALLGRRTILLWGASLITVLWLGIGIACCSSTTTAFWFVGCAKVTTYFVHGLSVGGIVPVVASETSSLRLRAKTQAMGFTVQLLISWVFQYVVPYMYSTAEGNLGGKVGFISAGLSAVALVVIFFEIPEMKGLRVEELDTRFEQKVSTRAFQHAANALTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URM0</accession>
    <name>A0A1Q5URM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000024">
        <property type="protein sequence ID" value="OKP15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URM0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URM0"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012231468" description="pectinesterase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="244"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="423" mass="45942" checksum="802C737DCC656FC2" modified="2017-04-12" version="1">MLRLYITAVFALLWHAASVHSVALNHVSRQECQATGNHCPKGTIKVSASDKHADFTTIQAAIESLPNDTSTQTILILAGTYKEQVNVTRAGPITLLGQTDASTDATKNKVTITWAAANKDNTGKSVDNVYSSVLVVSPTLNASLTGSGTTGFPVPDDTPFGNKNFRAYNIDFTNTWAEYSDGPAHALSFSRANGGFYYCGFYSYQDTVRKSKPLTKATQSTQSSYQSILTLPLQVYVGKLGNAYFYKSILAGQTDFLYGFGTAWIQSSDVLLRGCGGGITAWKGTNTTFTNKYGVYIVDSNVRAANTSVAPSIVGACALGRPWNSQHRSIFARTYEDASIKASGYIDWIVSGVARYEKNVTLMAEYRVSGPGFNATGRAAGNVTTVLDRDGFEPYSEPRKVFQNQEGVFGDVQWIDWETVYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMP1</accession>
    <name>A0A1Q5SMP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMP1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SMP1"/>
    <dbReference type="OrthoDB" id="3544487at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="16702" checksum="831F62B3FDEAFCEB" modified="2017-04-12" version="1">MERYKNEQPVIDCERQLSGKVVDEEVIGALQRTGYMTPQHITLIDSILTMPGTTIEEEYERRIAAINAAITVCDAEEGAPSRAGASQKRPVGAVDTPPASPLPKKKSLPLQIRVMTGFLEPSLLFALNLEKKDRRYAFYVLVMLGSQKVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SMP3</accession>
    <name>A0A1Q5SMP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13806</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000775">
        <property type="protein sequence ID" value="OKO89271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SMP3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="8">
        <location>
            <begin position="659"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="747"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO89271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="903" mass="102547" checksum="0E397B27529D614C" modified="2017-04-12" version="1">MDDTSPYVSRRSQRSQRIDYHLLNDGSDDEVPTEDRIFKRPRLNEPKVSPEPITPDDSVSQLDQNRSSPVESLQQNEFSEWGSSEISQRSTPSLPRGRPQNDSLWTQFIVSPLPGKLWSRKGAKRPAEDRKIQCKRCNWQTCDSARATSTSNMKIHLAKHGVFLNDTANAENGGGMTQQSISSLFRKRAETETSQRLEQNLLRWTVLDNMAFTAIESPAFQQIFRDIPGITLPFTCRKAVASRIDAEFVSFRGQLLSLLATTCQTIALSLDVWTSKNSKPILGVIGHWLDSDFHYQERVLEFAEMHGAHTGENMADLLGSTLEELGIEHKILTITADNATNNESLMSELYFNLKEKFLGVGETDAFHFQGADSYIRCLAHVLNLIVSDILSALKSGDHKTAVTACDLMQENKDIGMHSVLSRLRIMSLWIARTPQRKQQWKLICQTNRLNDKFIEYDVDTRWNSTFRMIRDALQAKQQIKKWIDSQTYLPPFTTEDWACLHQIESILAKFEEFTLTVSKRQPQISLAIPIYYELHDILNDAASREGEFSGLRADIASAVSSGLNKFKKYYDLMDGQDAYYVAQVLDPRFKTLLLEKELGKVSAHKVIKHIKELLHEQYPSPRVESTVTSSPDEPAARSIEARILQKLQPPKLQLSDVDRYFEDGVVIAQDPVIQDKDWLFSWWRDHCHEYPHVAAAARDYLAIPASEHRGHGAERKLANNNALVKKKIEKLNKQIAEELQIAGFVGSRHAPTPKDPCQLRDRHQRRKSSMKQRASQKFTDLRLKLARINKLLVSTRQVTVLNLRGTEQDDPDFYLVILPHGTRSSDLEVLSTNPVAERAQADPKLIACVIWENRNGLGILVEDDVVKHIPEGYIMTVEFCEAPEMGMASSSEKSSAVEVKPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQU0</accession>
    <name>A0A1Q5SQU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-xylulose reductase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQU0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQU0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12293" checksum="248383433741B0CD" modified="2017-04-12" version="1">MNMEEGALVEPVAVAVQITKVGAMKPNQTIVVFGCGPIGLLCQAVSKAYAAKKVIGVDIRSILYTAGCYPTAVDLIASGKIDVKRLTTNRFKFKQGEEAFDLVRQGKECDQGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SS94</accession>
    <name>A0A1Q5SS94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000756">
        <property type="protein sequence ID" value="OKO90864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SS94"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SS94"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO90864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18698" checksum="5738D1349ACF2F28" modified="2017-04-12" version="1">MATDIDMHDASPVPTLPHPHDGGRMHMSSLSSSSSISDAETDRRGRSERPRMASRKPSASILVPRDHPEIEIEEEEFPPDDARAMSPRRNSADLERLGKEARQTLQEQAKALQSSLQALAERIDAVKSDHDKLENENKILQDYIGGLTRNMTKSEMTRSTKARKAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUA5</accession>
    <name>A0A1Q5SUA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUA5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO91589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="68" mass="6933" checksum="B75F91790BE86548" modified="2017-04-12" version="1">MSAIPAELAAGIAEVLNPEGATGVDDTCTDEAAVAAVLLRYGCVGWTVGVAERDAAAWIERVKEGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUK5</accession>
    <name>A0A1Q5SUK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUK5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUK5"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841054" description="SH3b domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="248" mass="26525" checksum="2BF663911B7E3D93" modified="2017-04-12" version="1">MQLTNLALTLAAAFSMANAYAISGDGVNCRTGPSTNDAVVTSYPKGTDVKITCQTHGENVKGSTIWDKTSDGCYVTDYYVKTGSSSMVTGECGGGSSGGGTSSYNGKISRKEIISRGEFWVSRHIPYSMNAEYPDPQGREYRTDCSGFVSMALHANSPGYNTVSLPEIAKAISWDDLQPGDFVGTLGPGTGGAAGHVTLFHSWADSSKKEYNTLECRGTYGCVAYKRAVGWKDGSFTAKPYRYIRVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUP8</accession>
    <name>A0A1Q5SUP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_13033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUP8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUP8"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="390"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO91626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="850" mass="93800" checksum="B8D0462CD4908402" modified="2017-04-12" version="1">MNHHLPAMPHGQPPMPPPSRRQSDFYNPAPPNMRPPAYMGYPPHMNGHMPPAYSPQQYPPWYPPYGHMQQMPPRPYQPPYGPMIVSSYPQAQPIMAPTHMPTHSFSSQPRTSTPMQSTMSPSIPPPLQPEMHDPHAVLPVQQPHPPYGVPPSPPRWEPKPVLPDRKPVFTAPVPWLSVPESPFPAGPPFRRKNIRPMPDRPQFPPKDGRWIIGDRKGKLVKPKAVKSAAPVTSEPQTPTTSVPPSDGHSTQATTPSPTAKSQTQKKDAKPAIPIVPVVPNTPVASRREAKDSSSVGSETPKSTTATTESETGSTPAVDDTAKPTSPARSVPKSWADLVRSKNAARASSASAPPDSNTLAVQKSESLADVLNSLGEDVTQYSDKIAFLEPRGLVNTGNMCYMNSVLQILVSCVPFHQFLDHVGRRAAHSFHSDMPLIDAMIMFMREFNVIDAAASEDQLRLRLKPNELEQYGEAFVPEFVYEMIRQLPRFRDMRRGHQQDAQEFLGFLLEELHEECDRAAKHLSKSQDAHGIGGHATNGASADGEWLEVGHKQKAAVTQSSGAIATESPITRIFGGKLRSEFKVPGNKTSVTMEPYQPLQLDIGAHDVHNIIDALKGLTKPESIQGDFNSARGPNVTATKQIFIETLPPVLILHLKRFQYDSQTGATQKIWKKVGYPLDLEIPREVFPAHRRNILTAQGGLPKYRLMGVIYHHGKNASGGHYTVDVRRQDGREWIRMDDTVIRRVRSEDVAEAGGEEDPKVLAAALEQHRQDKIPRSNMFENIDHDDMESADSEKGWSQVSGSGSSGHSSKKSITVVTPSSGPSSGVRTPLGRYGSRDNRVAYLLFYQRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SV56</accession>
    <name>A0A1Q5SV56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prephenate/arogenate dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_12974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000744">
        <property type="protein sequence ID" value="OKO91901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SV56"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SV56"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO91901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="392" mass="43886" checksum="ED3D8A3254179CAF" modified="2017-04-12" version="1">MGRTKQDASIGIIGMGDMGKMYSQRLSDAGWSVEAGVIDRVVAQYGPSTKEGAIVGGQTSCKAPELAAFEKHLPSDVEIVSCHSLHGPKVNPKGQPLVLIQHRASDESLRFVDEILSSFGSKHVYLTGEMHDRITADTQAVTHAAFLSMGTAWQANNQFPWEISRWVGGIENVKINITLRIYSNKWHVYAGLAILNPAAKQQIRQYADSVTELYKLMIGGHREELKRRVKAAGASVFKEGTEGQDLLLKDEVLDRFSLSNQTREKSPPNSHLSLLAIVDCWSKLGIVPYDHMICSTPLFRLWLGVTEYLFRNPELLDEALDTAIDDNTFRSDDLEFTFAARAWSDCVSFGDFESYRDRFERIAQYFAPQFPEAAKLGNEMMKTILEKTENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW77</accession>
    <name>A0A1Q5SW77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW77"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW77"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="108" mass="11995" checksum="73D9DE09CFC03F91" modified="2017-04-12" version="1">MAILSAWFVDVVDTARLHAIALFCPTVRSERVFAAASPFVWEEVIQILRKIQPDNQSIPEPPRDERMTVGEVIPVARAAKLLAENFGQLGWTTMETCLEGGIKKDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZN6</accession>
    <name>A0A1Q5SZN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low-affinity potassium transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_12358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZN6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZN6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO93295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="664" mass="74420" checksum="AAD64674AD864762" modified="2017-04-12" version="1">MAVLPPCNFLTLHYLYFIATCLVTSIIFYLTSTPWKSVAYVDAIFLCVSAMTGAGLNTVDLSTLNTFQQAILFILLILGSAILISSTVLMVRKQAFEDKLKHFSEEREASRRASALELQNSTPELDATLNEGDSQVQLKGTADERLGESSTFRCDQIIWVDDDQITVGDVQARNHHHHRRVFPMAGVGARPDLNNHPRDVAPLPLYTDDFSVSGLKGIIRGTQKYFSSKGFISRNSQFYGLTSTEREKLGGVEYKAVSFLAIIVSLYFSMFLILGIVGMGAWLEANHPEVSEVNGLSPFWTGAFFAVSAFVNSGMSLLDKNMTALQLNAYPLLTLGMLILAGNTLYPCFLRFIVWTMRIMLPDTPSWKSWRVTLDFILDHPRRVYTNLFPARHTWYLLATIIVLNGIDWAAFELLSIGNKEIEALPTEYRILDGLFQALAVRAGGFYVVTIADLRQGLLVLYVLMMYVSAFPVLVTIRNTNVYEERSLGIYAHDETPETPSNTSRSNVLMDLMRHHMGRPTLSESSRGYFVHQQVRSQLSHDIWWIALAVLFIAIAESDHYTDEPVAFSTFNIIFEVVSAYGCVGVSVGYPGKNYSFCGAWHTISKLILAAVALRGRHRGLPVAIDKAIMLPRESLAWAEEEDAALRRERTRNWGQERMPLGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0T5</accession>
    <name>A0A1Q5T0T5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein arginine N-methyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0T5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0T5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="349" mass="39574" checksum="10692EBE013E7819" modified="2017-04-12" version="1">MSGTEAANATGVIASSADRMVGAEHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAARAGAKHVIGVDMSSIIEKAKEIVAVNGLSDKVTLLQGKMEEVKLPFPKVDIIISEWMGYFLLYESMLDTVLYARDTYLAEDGKIFPDKATMYVAAIEDGEYKDDKIGFWDNVYGFNYSPMKEIALTEPLVDTVEMKALVTEPCEIITFDLNTVTTADLAFKVPYKLTAHRPDFIHALISWFDIEFSACHKPIRFSTGPHAKYTHWKQTVFYLRDVLTVEEGETVSGVLENRPNDKNKRDLDINLSYKFEVEDPTRSAEGSCFYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0V3</accession>
    <name>A0A1Q5T0V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-induced degradation protein 4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0V3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0V3"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO93715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="66803" checksum="9E7F771FAFB61C5C" modified="2017-04-12" version="1">MPPPNSASHGTPALSPTTPAPEPLSRRSSIPDSPIPVESDNAHDENVNFLRSRSLLYNPLLPALSRHRRRRYQTSHPRQMEDLPADDRMDLDDPSNLRLSVEINRRIPIVRRHREEPRNMPNYESRRSNSRSLYGWAPGSDDEDEERRREESDDDQIQPFLHAVPDRNTTSSRSRRQEFTAHTPPITAAGDGPTEASSRWLNGPIPMELLQSTRRQPRPARTRTLENFLLDRYGARSNDEDEADRTWSSSSTRAPAYRYRPPSSRDSHRPLTHSDLRARVAAHRQLHSSTPGDSVLKDTINYLDRLRYSNSFEESINSAAATGFISLENFSLKDSDFILDINTIVPPAPCSWLRPGVVFSGCQRAANAGCSVLSQRVQSPHTPTEPVIVNGSDSTRISVYTSTGRRYFANARDENWPVKVTIHSINYTDMTLSGTMEAYNIPDKSSPTHDAHIVTFLEGEIIDFNKHTLETKNFKADADIDSTYWRELPPFKDLPDSEIAKNLVSKKWITEELVQGWILMRWKERCFITPTDARQGLTISGFYYISLRREDGHIDGLYYDPGSSPYQQLSLKPETSKMIRPSYNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2B4</accession>
    <name>A0A1Q5T2B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent urate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2B4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2B4"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO94312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="424" mass="47672" checksum="7EF794A437F44269" modified="2017-04-12" version="1">MVSSSTPKSVTIIGASVGGLTLALVLKRYGIQSRFFELRDENHDFDGAVSLTPNALRVADSIGAYSRIKHQGFNFEAMTFMTDPEHEITGKLYFGQKDVYGYDGIRITRKVLIHELREMVKEAGIEIHYGKKFTKVVNEDDNGVEFEFADGTREKAEMLIGADGIHSKVRSYLFPDIHPHYGGFLGLTYCFPRANVRLDDDFPLPVSLRGEHGSFIITPQAEGGKEIFVGRQLKYEPQDRAGWSAMLRDKQAVIEILQRDPTAWTPLVQSVQAQASAPDAHFLNVWPFYTVPKMDRWHSSTGKVVIVGDAAHAIPPSAGQGANQAFEDAYSFGMLLATLNGKSSWSDALTAWETYRMKRMDEVLRLTNRLLTIRMTEEERASVPEDMRWELDWSNAGKSQLGWLYLVDIDQDVENLVKTLNVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T2R7</accession>
    <name>A0A1Q5T2R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein bem46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000719">
        <property type="protein sequence ID" value="OKO94534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T2R7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T2R7"/>
    <dbReference type="ESTHER" id="9euro-a0a1q5t2r7">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="104"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO94534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="310" mass="34346" checksum="0C79DCD3B0F3F1AA" modified="2017-04-12" version="1">MSDSPPPPSSWSIGNMTNSAVQFLRLPVLASSGLAVVASGLLYFKQNELIYPRNVPVDARTNVPSPRQFGITDFEDLQIPTPDGETLHAFFLRPPKSRYRRNLTVIMFHGNAGNIGHRVPIAKAMQDTLHCNVLLLEYRGYGMSTGMPDEAGLKIDAQTGLDYLRQRAETRDDKIVVYGQSLGGAVSINLVATNQDQGDIGGLILENTFLSIRKLIPSIFPPARYLARLCHQYWISEDVLPKISKVPVLFLSGLKDELVPPSNMTQLFAVCKSETKIWRTLPNGGHNDSVAEPGYFEHIHSFVTEEVLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T422</accession>
    <name>A0A1Q5T422_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000708">
        <property type="protein sequence ID" value="OKO94953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T422"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T422"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO94953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="305" mass="33982" checksum="41FE805EB9E09902" modified="2017-04-12" version="1">MPPRISVQPSWKALTGTLYGQTPLAAGLPHATNASLRTASTKAKAQPQKRSDFFMIAQARQRKAANLSRQKVLQTEREASLGDPVQSKPTPFIQEIEAIQNGSQVLAASSGLNYYLKSDELSSALQFSKDLTEPLQNPDRDTADPQLEKEAAELHQKEHSIAMDAIQRIVNLSNGNTKDRLRLNVQRCIEQFGRHNTDSILPPKPSSILQGSMSSHQEKVPRIGVDTGSPEVQVAILTVKIMNLSRHLQTANKDKHNKRNLQVLVHKRQKLLQYVRQKERGGPRWQNLMETLGLSDAAWKGEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4P4</accession>
    <name>A0A1Q5T4P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Brefeldin A resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_11277</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000706">
        <property type="protein sequence ID" value="OKO95198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4P4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4P4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO95198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="556" mass="62292" checksum="473DCEB54D12463A" modified="2017-04-12" version="1">MTALMGLSGAGKTTLLDTLAQRINIGVLLGGLYLDGCPLPQSMGRRTGFVHQNDIHLDSSTVREALQLSARLRRPESISLEEKMTHVEVIIKLLEMEDIADAVIGVPGAGLNLERRKRVSIGVELAARPDILLFLDEPTSGLDGNSALSIVQLMRKLSNAGQTILCTIHQPSSQMIELFDSLLLLIPGGKTTYFGPLGPRCKKIIDYFARHTRPCRDTENPADYLLEVSSSTETDWFQIWKESPEFLATQEQLQDILQEKEDTSLSGSDKAYAVPYLEQLRVVTRRAFINYWRDSDYVLGKVQLNIWMGLMNGLTFLQLSNDLADSRGRMFSIFVSVITGPVLSLQIEPRFIILRDQFLARENESRVYHWSVFTISALLVEIPFTLLGGLIYWLLWHYMVGYYYTSDRAGYAFLMYELYSLFVASLAQLTAALFPTVLAAQTATGFVWLVVNTFNGPLSPPPLTPRGWRWFYSISPLFYYIEGIGTNAMHALDITCEGSEIQIFKAPLSETCASFAAEFFNMSNSTGYLINPDATDQCEYCSYADGDQYVSAFCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Z8</accession>
    <name>A0A1Q5T5Z8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_11161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Z8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Z8"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO95649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="206" mass="22439" checksum="DD0A3C3AA51A323D" modified="2017-04-12" version="1">MGSPFDINGGACVAMVGKDCVAIACDLRLGMQALTVSNNFPKIFNYAPSTYLGLTGLATDVNTVSDLFRYKVNMYRLREERHIAPQTLANLVSSSLYEKRFGPFFVSPVLAGINPTTGKPFICGFDSIGCIDFAKDFIVSGTASDQLFGTCEGLWEPDLGPEDLFETISQALLSAVDRDALSGWGAQVYIIEKDKVTQRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T6P7</accession>
    <name>A0A1Q5T6P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">PENSUB_10930</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000701">
        <property type="protein sequence ID" value="OKO95909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5T6P7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="589"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="892"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="979"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1099"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1244"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1285"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="908"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1128"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1245"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1333"/>
            <end position="1347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OKO95909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1407" mass="156399" checksum="8B4C9E28F5336AE6" modified="2017-04-12" version="1">MMSAASFMMPVGERPPQYRTPSPPRRAVEPITPSTADFRASWAERGIARSASLDHDQRSSNHARIPPADAGSHHRSGHGRSNSTIDTLATIALATSPTFAPLPPRPSSPNSRSTVPLFPPEPQNAERPAKRPRSERDPSPYRSSSSSSRAMPPGNPQPSILDSMKTDAELLLNFARPANFQPSGHHTKRVSIDESYHLHNNLYGGDSGQHNRVGFPYAEHGGSPEDIKLAYHHSEDHIPLSRMRSRSDGSAFLSRPAIRGVRPTTSAGTLPSIVWEEDNEDAAPTTEVSRYAGYGEYKPLGPQQEPHGPHSTMDLTPKVEDEDDGSDTNQASCAACHMIRIPMEPEEQQEEDTWIGCDGCKRWFHIVCAGFKNDREVRTVDKFICRNCRSTHGQTTFVRKSSRARTAIDYAGLNQGVVKAASDSMEHHYLEPIRQGKIRFLPESFPRMKPELVTAEYFERGNGWAEPVVIPAAWNTREPVPELDAEFESLVQEASTQEMFDDLLEHLEEHETPLRETVDCGQDQLDMVIPQGLTVRAVAELYGPEERVEVIDVKSQQGEDKRWNMQKWADYYESNEPDKPVRNVISLEVSQSKLGRLIRRPKVVRDLDLQDAVWPEEFKAIGDYPKVQFYCLMSVADCYTDFHIDFGGSSVYYHILKGKKTFFFIPPKDKHLKKYEEWCNSPAQDSIFLGNQTKECYRVDLSEGDTMLIPSGWIHAVWTPENSLVIGGNFLTRLNYGMQIKVLNIEKETKVPRKFRYPFFQKIQWYTALRYLEDDPIPQNVMDAFAQDENYRFHRQHPIYYEFGELANQEPAGSPYFNARFYSQAELEGLPELTKYLLRTALIASSYNVEGVTVDARNAVRRSIPKGVVEPVNMIRKFGIWVAWKRGNEKAPQWTQPGVIESNPKVSLNEKKSAGRPSRRSERNVDSQRTYAERQAVQRPSDEVVSTPAPPVNNNPPVYPPIESTTPVPAAFLPEFVARESSSASKPRTAPRGSGLGPKRVACDACRKRRIRCRHKDEPNDLGMLGGQLGVNGFGPASGLSTPSSLAQDAVSALNSLAAIASQAGFQSNGVVGFDRFDGSGKFHSAVMGTSTAAANRLHDLSPDGVNGGKKGRSKACDDCRKSKRRCIHDEYGRVDPIKAQERSKPRGTASSKRPRPNDDDSAPAPAKKTKQESTSPMTHPMDFDGYAATAVVSQDIPADVTAYDAINHLQAQPSNVTEVVTVGQALYASPPVHHVDSLDIKDANSLSAPSKPTTSLVSPPTSLADEMDVVQDGEPLASVEGEVSTALHTPNSSSRHSSRQPRHVERFIPEATAPRPSKPAMPSTARRTTPGPSSSARKPSSRPSSSHAKKSSPMVEKRFDRHATTSLSPHQSKHVKHRIEDDADAESLRLIRELQEEEFGLRRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9J6</accession>
    <name>A0A1Q5T9J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9J6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9J6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="242" mass="27885" checksum="CA4E9AFAF7343982" modified="2017-04-12" version="1">MELSRQEEEFEASEWVLFTKVNEQAFSRDFLNSDDNILQRCWNSYNSSQHLLLVKMTVSRAHEIAARVFERLFFDCLKPMGLDDCLQTFGSATCKAENGSAKQPDCQFLPRRLPRARTKKWPSVIVETGFSESPSKLTSDARFWLSESNGDVQMVITIKIGRSSPNIVLESWELVNNRVQRQQVITISKGDNNHVYLRGQPLIISFNKLFLRPPSIPKEINISLDDDILKKIARNVWEEQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TAU0</accession>
    <name>A0A1Q5TAU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin-2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TAU0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TAU0"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="160"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="549" mass="61251" checksum="FED0FBF6009772B7" modified="2017-04-12" version="1">METPTSSRAPSDALPVENGQAGLAARRTSLGFLRRSKSTEPLGERKPSGSRKKMSKSQAMEEELRRQRESYAPKIAPRLPDLSPTPQLETFGGEERDTLAPEPAMPRPHSGIPPASMSSPTDAVDPYARTESMTHRGRYSYASSAISTVNSPRRIRRRKDPTPYNVLVVGARNSGKTSFLNFLRKALTMPPHKHPSRSPEELEELERQTSAYEGFTSQYLETEIDGERVGLTLWDSTGLERNIVDLQMRAVTGFLESKFEETLAEEMKVVRSPGARDTHIHCTFLLLDPVHLDENIAAAERIANGTAKATDVPVVGVLDQNLDLQVLRTILGKTTIVPVISKADTITSAHMGYLRKAVWNSLKQANIDPLEILTLEDQEEYTSSESADEEESVQGETPETPTEPTEEVSESKDEQTDEKNGQDQPPQPTPESPSQRSQNSLSASPANPHVPFSILSPDPHSLASGEEPVGRRFPWGFADPYDPEHCDFVRLKDSVFSEWRAELREASRVIWYERWRTNRLNRNGQPTPLPSKKSYAGRMGPIHDGRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBC5</accession>
    <name>A0A1Q5TBC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_10349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO97555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="335" mass="37762" checksum="8FE227D124BC320A" modified="2017-04-12" version="1">MSESSQVSPRPSAVPASPLALLWSYEFRRQNGILTSHLLDVKVQLNERGQLTEFLSKSLNDLIVIIASMVTVLAGYSDGGEHRIRLLHRLLGQAMAPLYRYAANCDLGNQALIDCIAQLEALYELPAIFFDGDEGDAATSLSSALSAASDGIPQSPRSAHGERAKSTTESDQHDDQHDDQHDDQHDDQHDDQASPNEAREALAVKLDAVMHQEGRPLEDYFDAACDFRRDQIRLGQANDPVFLEAFLAGCDNNLYRRRLTHALRKYGWYWTWLTHEVQYIILEQEYMDKQSYALEHVNPDGSFMWPDGTSKLRIVFLPPITEEDLTDSDLESDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBI3</accession>
    <name>A0A1Q5TBI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional activator protein DAL81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_10367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBI3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBI3"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="646"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO97573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="702" mass="77472" checksum="5B03D029D01AAAF6" modified="2017-04-12" version="1">MATVITIQPSPTAGSAASPAYSHSPPDHLRRRAHPASTATPNTLSPSPVAGQSTIARVSRRDGASCDACLRRKSRCAMNDITNKCYSCDFHRQDCTFTLTAGSGEAPMKKRKLDDSAREHESIKRPSTVQSNHSLADEAPRTQHPQAMIRSGFFNQTTQHIGMTTELEPTLLEYLPLDEYHECTVSASRIRRCADDCTFMRVVNTVPIGDSQAVSLDAIESLVAPYGSTLIEKFFEHVHPSFPILMEDAFRQSYRERRQLSPLLLAAVYVLTLKFVDVGVSSQTARRPDASRLESTALKLLIESLPYPSISTIQAGLLLTQKSTLATASLNGQLVTAGFELGLHQDCSNWRMKTWEKGLRKRLAWALYMQDKWSSLVHGRPSQIFAFNWTVKDLVEQDFSDAFASGTGSAHDEGDVGHGPLLFCHMVALTTILSDILDRFYTLQAIEDFRAAGNQRTRIILDKAKPAQIRLKEWFSSLPAALKMESSSGELVETITDEHARNGALHLAYFATEITLHRCIVRSLASDGTDSYLAHICRSAAKTRLISAMDFVNRLRPAHLRSFWPASARTNFSLIGSFGMLLRITAPTNEEAEFYRVRLCEYRWTLSVSHKNAEFMGFALESLDHATMLDKHVPAKPGIEELMASAAKQPSRPTMGPGDYDDAMGDIDMHGTAGSSSVISGLASPATSVSDMEGDETHMQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TBM6</accession>
    <name>A0A1Q5TBM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000688">
        <property type="protein sequence ID" value="OKO97639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TBM6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TBM6"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO97639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="459" mass="50078" checksum="38591C1C08692AB2" modified="2017-04-12" version="1">MTSDDQFFLDYLASIPHDVRRYSLQVADSIDRQVDWAAATIRETLAHQSWLPTAVRPTLRMRDMRSPPRGLTDRVQDWVARNRALTAAIVAFVGTGCVLLYGNKRLNSKRRKARKAGNGSRKEIVVLAGSPHEPMTRAIAADLERRGYIVYVTVSSAEEEHIVQSEHRADIKPLWLDLTTTSSNQSELHPSLHELRALITQPQSPLPGMPPHTCQLSGVIIVPSPNYAAGPVATIPASSWADTVNTRLLSPILTAQVFLPLLTLRSNSSSLIFAYPSISSSLSAPFAGPEVTTTRAISGFATSLRQELRLLENGKVDVVELRLGNIDLGPSYRNAQNHIAGTEVLAWSVQQRALYGPQYLNSVEQRPVASAGPAAIRGSPARVLHHAVLDALEPASRNIFGRRAHKKSVLYVGRGARSYSLIGDWMPSGLVGLMMGYRSGQTVGTGSSSSGSENSWERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC01</accession>
    <name>A0A1Q5TC01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_9677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC01"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC01"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="273"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO97751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="356" mass="41144" checksum="52E8C62360D032ED" modified="2017-04-12" version="1">MGSCFSSESTGDAEQKKRSQMIDRRLEEDQRRLRRECKILLLGSGESGKSTIVKQMKIIHQNGYTVEELALYRLTVYKNLLDCAKALIDAYHHFNLEPSSQKVKDYIALLEEYHVDPDPNTPLDGKLGDAVTYLWNDPCTSTVLERQNEFYLMDSAPYFFEEAKRITAPDYIPNVSDVLRARTKTTGIYETRFTMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQTLLEESNQNRMMESLVLFDSVVNSRWFIRTSIILFLNKVDLFRQKLPRSPLSNYFPDYSGGNDVNRAAKYLLWRFNQVNRAHLNLYPHLTQATDTTNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCG5</accession>
    <name>A0A1Q5TCG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCG5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCG5"/>
    <dbReference type="OrthoDB" id="4331421at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO97922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="587" mass="66580" checksum="70BC948C89D197B9" modified="2017-04-12" version="1">MAMKELLRVHREIRDVNDDFHSLRTVLKETDHKSKWNFIMFPNDGALSHLPLIGELVIPERYPIDPPVLHLFTKTLRMNVDVYQHRLRDDTQSTMCFDILRPKAYGGTWQPEYTISCLFASLMQALVTPMVPQDYGGDKPEFVTMGRLEEVKGHVEKTYRAHKNHIGCLPTIPTIAATPIPAQPLTFSRPGKDETLKSLDFVKENMYTSQAIYLQDFERPQFWSTLLDLRNLHPGVVFSAILSNKPGVDLVGRKADTILLRNGVTGTAAKKRENLPLVWFYHGKPLNDQNLSLSITITNDQFTMAYKAEGSDQFLVHGDTPISKLGEAQIGNVKGIPFYLTIYLKRKSGDEGFISVLDQEETGYIHVNLTTLAVHQPSKPTNRPINSVRLNLGSEQTARLQGVIDVYGLGLDFKVQRGITKPAYLKLASGGDMPEKEWTEIVKDVYGPLRDKPVKAEVTAIAADKYCVVLILNNHCRSEKETEKEEDEAQKEEANEKGEEEKERDEEKNEGDEKNESKEEEERNLLPADKLSCITMRLRDESIKADYPAIFAQRVIEEHAKDWVSVGDIYIQLPQPIKITCDVEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCP3</accession>
    <name>A0A1Q5TCP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO97988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCP3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCP3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF16">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="311" mass="34612" checksum="7C4365003C3221F8" modified="2017-04-12" version="1">MGTVWTGDPLSLDPRFSIGGRDPGVNNLLGNLGGLLGEPQGLIGSHNFIEADSSNTRDDLYVTGNNYALNMEKFMSWYNMSVDGSFDMDLMAKRAKIRFEETIQTNPNFYYGPVTGLIARNAGYIFPGRLFRNHSRENPDGTLTKSHIQNFYGIYGEEGNFIYREGWERIPKNWFKTPVDYGLLQLNLDTIDWMAKYPELRSIGGNMGKVNSFAGVDLANLTGGVFNLTNLLEGNNLLCFVFEVLKFASPNALASLYTTLAEPLGFVSDILSVPLVNFTCPAFQDLQMSGKPFWEAIQNDFPGAMHSGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDL8</accession>
    <name>A0A1Q5TDL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDL8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="86" mass="9474" checksum="7A6120B6AC69CE31" modified="2017-04-12" version="1">MLIPVKISVHLQFQSIQPNRPSRTLPEGRRKDHGIVNPPTTGSITQGTTQMQSVLLPAYHSALSRNANLYTVTYFFPISGGVVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDR0</accession>
    <name>A0A1Q5TDR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_9451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000673">
        <property type="protein sequence ID" value="OKO98353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5TDR0"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="966"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1143"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="560"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="732"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="906"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1303"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1303"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1326"/>
            <end position="1341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKO98353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1464" mass="160366" checksum="43141587702A5F32" modified="2017-04-12" version="1">MDFPGGATTNIHLIDGFSTIYWRIYTEESGIATHPQEGPANGYTILKHLGRLKNLEAQLRHIGCLASCPRRLGLWVFSPTPTFESLGPVYITDGDVETTKIFLNTTTLKVSASGSIACQELIKGLSSETQNQQGSLPTPSQRPQQAQPSARRSDGYSSSVAVYSAFISAVTGALSLHLVRTYGALPIGSRTLFTAVDNIGYESPRIDNEGLFSSPSLTTLNVQLNAPGTLTVSTQTIIQAGITRLSSPRDDISDLFRVQPGADLWLCPNGAIARLVTANIESPTVPSPGFPASGDTLAKRMQWKLDVVQWLTNFGLHIDSIDEEPWVEVEVWEPFFARLAGEAWRQSDEPQSALPLKRMLWPARFCFRRTGLPIRSAWPEAPLEEPLEFAERWSSDAGSMKLALPSQSVPTFEESQPKDEGMSPPRVDHGDHLESLSRMAQYPDLQNTNLVYPTPPEGATAAGANIPIQHDAYPDSDLLSPEVPHDTKPLPSSGPSPNVDIGTGHYDASDDDDLFGEMNDKDFGSKGITDADFSFFDDDDQDLGDMADPMLVDQPQEIPQEPVDTIHTKHEPPHVQDLPAAAVSPEAPKVEDEPKPEETSISMKDDPEPADEPMELEESSEPSQGPPSQTISPPLSPVEIKKILFPGSQTEDRRQSQEDQTQQGHYQPVAFQRKLGAWDQKYGAAGKFWFSAGGAINPSVNDLNEIPTVGLPNRARTSISARNKPVAKDFLQAVEDERERDSSDSTESSSEEEEDSDDLPFDHASTPVALPQLKRKRVPSESDIQSAASPAISSVVADGGTGSKAENITFLGNFLSNFSDWTFTGYFSALQIQQLPVLIRREEQIPIAQLLVDQITQSSLNHSLGQQVGLFALESEGTSFTECFDDVAFMGKIQKLDLKGYTSLQEDKTQSSSQSQQPTKESSKNSISKLCAPHLRVRRGKDYLETLPPAMSFWETFGLEPAHGSKDISAYCIHPQAAGQAAEAFLHRFGLSYESCNFGTHSRGDNSTGFDNGLKSWDSESSGYTSMMQSLLGLCEELAAELSQADVPTTNNSVVYIINPFPHAAALADICAAFWNLFQQLVADAERRQSKQVNEVVLQIIPMEFVMSEESMVMPTQTEYVNLALEVYSRCRPKDAESNPLLCAPAILLAENLPKNLNFRLSPDKVSPLQDGRSLHIAYSKSCDQRWVSAAWSDGTGSLQTSMSYCLRYRNRGSSRAVSEVRNEIWATTKHIMDKFQARWKVVLVSTDPMDPDEVDAWSNLAEQQNKMRPASLELTIITVNTIPDLTLNTPASSMSSGVLNPHFSSTPVSTPNPNTSIASPEQAGNAPTPSAVYNASTPTEPSLEPDSDVVLTDVCDDSWAVILSHRLNASPHVTELRPALVSGYLLRRKGATDSEGVFSMTVNLLYSQRPAISHESVLGDILAMYRDLSCLARARGMRSVQGNTLPWHIATALRAQELLSYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TE99</accession>
    <name>A0A1Q5TE99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional repressor rco-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_9232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TE99"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TE99"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000030">
        <property type="entry name" value="Putative transcriptional repressor TUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="313"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO98556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="507" mass="55959" checksum="DB661E99FC4CC664" modified="2017-04-12" version="1">MYNTHRGMVPAPNSRLTELLDQLRQEFESQSRSTGEYEHQLTGQLQEMEMIRQKVYQLEQTQIKMKADYEAEIRMLRHELEQRGVQPVSSHIAPAQHTGPQAQPPSLGHGPSNLFGGIMTNQGGYGPPPPPTASPGPGKGRRTAPGPATPQQTQIAYPDPRASPQIPRPTPPNQPLVRADRPGNMLANWDPADLPASQKREGSDWYAVFNPEVQRVLDVELVHHLNHDSVVCCVRFSRDGKYLATGCNRSAQIFDVTTGQNVATLQDENVDKDGDLYIRSVCFSPDGKYLATGAEDKQIRVWDIAARTIKHIFSGHEQDIYSLDFAGNGRYIASGSGDKTVRLWDILDGKLVYTLSIEDGVTTVAMSPDGHYVAAGSLDKSVRVWDTTTGYLVERLENPDGHKDSVYSVAFAPNGRDLVSGSLDKTIKLWELTVPRGMHPHSGVKGGKCIRTFEGHKDFVLSVCLTPDGQWVMSGSKDRGVQFWDPVTGNAQMMLQGHKNSGESIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEV8</accession>
    <name>A0A1Q5TEV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamyltransferase YwrD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_9019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000666">
        <property type="protein sequence ID" value="OKO98768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEV8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TEV8"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO98768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="64335" checksum="BFBC9E60D55DFF38" modified="2017-04-12" version="1">MPLNSKAVYAKSDAAYVPFASRRSTVHSKNGIVSCTQPLAAAAGHKILSQGGNAADAAVAVAAGLNMTEPGSTGIGGDMFCLFYDAKTKKVHALNGSGRYPGGATLEKVREKLNLAPGAEGSIPMLSALATTTPGAAAGWVDTIEKFGSGKVSMEQILQPAIDMGENGFPVSELSSNGWQESENDIRNASPNFREMLKIDPSAKDGVRAPLPGEIMKNPTLAKTFRTLAAEGKKGFYQGRIAEQIVKVVNDLGGLMTLEDLAYHAKVGTQETEAISLKFTGQDIISKQNPGTDGEANQGVEVWEHPPNGQGIVALMALGIMEELERTGKIPRFSPAQHNSAEYLHAVIESLRIAFADAAWWVADPDAEKVPSKGLLEREYLAERAKLFSPDRAADILDHGSPAHNHCDTVFFAVTDSEGNGISFINSNYAGFGTAIIPAGCGFTLQNRGANFSLEAGHPNALAPRKRPYHTIIPALITNVADGSLHSVYGVMGGFMQPQGHVQVLLNMLAFGYHPQAALDSPRICIAAPTSESTDRTIFVEEGITDEAVEGLRRLGHKIEVLTEWKRAMFGRGQIIRLHYDEGSLVYSAGSDPRGDGMAFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFB0</accession>
    <name>A0A1Q5TFB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFB0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="102137" checksum="3FDA78BCED2AAC4A" modified="2017-04-12" version="1">MSTQTAPFIPPRPARSPQPPASIDMPKIPPRPSNRRLDRSVSPMRDSYAPSPFNEWNGPSIARTTSNDLPPRPPSVTIPSLGEEGIEYADLDVGNMADSHQQAPTETRNVNTDLKIHAPRPSLPTSSAKARVQAVTRTDSRQAAAAGLGRESSNSPALDEQDRPRRTSNSRASHSRADSNASSDRRLSAHLGEEHGFRVPMYPNAGDVQAPSPSPYLEQGTQRQGRNHHRSRSARDSSLPPGSYGLHGHGVQHADKFEKAWYEKHPDEFVKEEGQYGPGVGTPRPDWALSSDDLNKIVRGPSRSGPGLGTSPAATGTPEEEVGYLASDEYMHRMASPPPDARNESQPVVESPLRQMSFPASEIEPKVPASPLRHGRSSSHGHRADGEVIHVDDPMHPLHHPDGFAPTPAPYEHTPDVQQPLEDDEPILAADEVRPDSAYLHPAISPTFEHRGSLDEERSRTPSVSHSRSNSRSASAQGAPMLTRFDSREPHEDMSTPLEDVEEYEPLFPEEGDSKKPRSLSATERFKKRPDVHRFPSEDIWEDTPNSLQLHATVTTPDIPKRESSELFETPEQEAARRMQTSKVDSHQVARHILHGDGARDKAKVPARPDAVKQRFPSRDIWEDAPDSQQLVTTVDPANDEVKSPDVPSKPSIPPRPQKQVQATSPTDKRPAPLIPDRPKPQIPARPAKPGSQSAEGAAAPKAKPAIPARPGGSKIAALKAGFLTDLNSRLQLGPQQPKPQEKEPEPPAEKQPLSDARKGRARGPTRRKPATENANARLPTIPEIKITETWNVWSVGQDGNLTVGSEDKKPSVPAAEPSVPSEPPMAPQLAKNTAGESVDPVPVTKPAAEEVFANTVAAREAEAAEPQVLKDVPASIETPSAATELPSKQQEPEPTTSPAGAQPLADHVSTSTKMDDVLEDLAASADGKKTSDGDIHPTESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFD6</accession>
    <name>A0A1Q5TFD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFD6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFD6"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO98946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62155" checksum="3B0ED83280E41659" modified="2017-04-12" version="1">MTITTTSLALGKAIPEGPHAISVQIPTWSDMCGMGRGDVQIMEALQNGYPRTFIHQTIQKLCRACQSRFLSSPAKILLFPDQKSAQTCKNYITSSTIHKNEAVPSKSVSIIALEIGESQPTFLYAGQTPGPTLWAVVYPEESAKPGALFWRLTGTGISSRLAEHCLQNIDSMQRVERPVKRFYSAMTTVHPVYETIRTRIAYLMDRAPAETPRNLTVKHSDVFLYPSGMSAIYHTHQTLLKWRGLESVVIGFPYELTIKMMETYGPSFKFYSLGTEEQIDEFEIYLDTKARIGSMIQAVWCECPSNPLLYTVDLGRIRRLADKYGFIVVVDETIGSFANVDVLGVADIVVTSLSKSFNGYADLLAGSVTLNPNSGYYRALKTCLTEGYTNNLYIDDAIQLEHNSRNFLQRAAQMNTTAESIVDYLSPFASDPSSVVSAVHYPKTCQSAHHYESRMRNATDEFTPGYGCLFTVDFNTLDASRAFFDSLDVWKGPSLGANITLAQPYVQMVLQKEKKWAASHGLRETIVRVSVGLEGKDAILQTVKNAHMMAEKTKGTHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFJ4</accession>
    <name>A0A1Q5TFJ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_8921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFJ4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFJ4"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO99004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="124" mass="14106" checksum="9E2AEA6176BC57EC" modified="2017-04-12" version="1">MAPAAARGRKAQKVTKKYIINASQPASDKIFDVSAFEKFLHDRIKVEGRVGNLGDDVVISQAGEGKIEVVAHIPFSGRYLKYLTKKYLKKQQLRDWLRVVSTSKGVYELRFYNVVNDEAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TFR7</accession>
    <name>A0A1Q5TFR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO99025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TFR7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TFR7"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO99025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34135" checksum="6289A1E1F95289F0" modified="2017-04-12" version="1">MDGSHPPEAMRSSHSDSRDPTGPNSGGAPERVPKEDVMITLSLSPEPPAPPRTRSPLARSHLRSRSLVGIPGMPSMTRAYSSPGMDSRGRYIFVNGRGVPAPQPTIDYAKRSTPLQMRSDDHIETRLGSLNISETISENAELETVPRSPSSQSGSSPVLMPQTFPRIGRLRSTSPLHFQQPISSLPSIHTSPTLGGRYNEAYPVHSASSASSVPSTPTSLRSRSPSISSLETIPDIPDAEAEALEEERIAELKAAADAADAASTGRRRGGSDMSTPSSFGTVRGGASAYAPRSDKRKRWSVCGAERRQDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TG34</accession>
    <name>A0A1Q5TG34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_8569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000664">
        <property type="protein sequence ID" value="OKO99182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TG34"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO99182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13872" checksum="6F2DC7E4B0D77709" modified="2017-04-12" version="1">MIYEHLLVAPWPLDVDEWVSRDFQNRTWGLVDPAIVRTNRQIFHESINTLYSKNEFSVMLARFPEKVGRFLENIGSNNAAQVRKMGIYYPGGVLQPLPIDFPDTENYLNLKDHPVPVGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5THZ1</accession>
    <name>A0A1Q5THZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_8056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKO99839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5THZ1"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO99839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="477" mass="52698" checksum="6FA024BB4E4002DB" modified="2017-04-12" version="1">MGIGYLVSTMNGFDSSLMGAINAMKPYQDSFGLTGAGSSTGLIFIIYNLGQIAAFPFCGLLADGYGRKVCIFVGCLIVWIGTAVQAPATSMGMFIAGRFLLGLGAALASAAGPAYTVELAHPAYRGTMAGMYNNFWWLGNILAGWTTYGSNLHLKNSWAWRVPTIVQAGLPGVVLVLILFFPESPRWLIAQDRREEALDILAKYHGDGDRHHPVVQLQYHEIVEQLSATRDENPWWDFRELGNTRPARYRLFMVIAMSFFGQWSGNNVVSYFMPQMIIQAGITSPDKQLLINAINPIFSMLGAIYGATLLDKLGRRTMLLWGLTGGLAAYIILTAFTAQSEYHPSLSYGVIVSIYLFGIIFAWGFTPLQTLYAVECLENRTRAKGSGLNFLFLNVAMVVNTYGISVGIEKIGWKLYLVYIAWICVEMVVIYFFFVETAGKTLEELKEIFDAPNPRKASMKRTKVEIDESGTVVGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIH3</accession>
    <name>A0A1Q5TIH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat-containing protein C19B12.01</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_8221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIH3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TIH3"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP00023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="932" mass="103599" checksum="6279AF5F743322D7" modified="2017-04-12" version="1">MAESVYPHTLNGVFDAPLNARYDPIRLTSDHIVPILELPLAREVLGLDASDSEAIAKIVNSEISYTTFVADQARAILKTPRDGLTSEQIQSQLVHIGLAALFTFLQSNVTGPPLEFNSAETVLPSSLRSDTAILRGVRAKIIRDLSVDGEAAYKLTPNPELFSVAKALLVDASVDGSVPAKIARVRTNFLHQKMLSEVTSTLQDEIYKDLEVLVKAELDVEERSRFLLERAIINTHHGFDGKARADLHQASQVRNFEFALTGKLGKRTKFQDRDISQLVVVAKSADVTPKPTELSGPKNVDLNDDTLLEAISFADKKSSTVSDELPEGLQSVDPNEQPILNPVDSAILLAMASAITNTAPENGLTREETQPYATRVLEGGSSNWQIYTEALLVRSRVEGFRSRTVERSVLQMQALVDQVIADTATADSAAQQPSSDPTTFLPRPEKSESAPAADRLEYIWLMNFSTRWNLEAELAKRWVELGGLRTALEIYERLQMWAEAALCYAATEREAKARTMVRRQLYEAKGSDEDDENEQFEGPERSTLPADAPRLFCILGDIEKDETLYERAWDISGQRYSRAQRSLARHYLALTPPELEKAEAAYRKGLHVNRLNESSWFALGCVQLELQKFDDAVESFTRTVQLDDTDAEGWSNLAVATLRSTTPEPAPEVEIDETTGEKIVKETDPHKRKRDALSALLRAAQLKHSEARIWDNVLTVAASIPPPATPFRDVITAQKRIIELLGEKKGEKCIDLPILSMLVDFLITAFDYDSLLIQSDDGPVVRTGTIPGQIISLVDNNIVPLITHSSVLWLLVSRVEMFRNRPSRALDAHEKAWRATVAASAQGAFQMGDEKPWMAVVRATEKLVRDGYARYGPMDHEAKKGEDGAEAEMVMRDWRFKARSAVRGIMGKGKDFWEDSEGWELLKVLQGEVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TIK5</accession>
    <name>A0A1Q5TIK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_8255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000653">
        <property type="protein sequence ID" value="OKP00057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TIK5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP00057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="64" mass="7293" checksum="99EC087AE3D4A3D8" modified="2017-04-12" version="1">MQVEAGLGKGALEKARAGLIKQVVRTRHPVDRQLMETRSPKQFTPNPGQYPISRPRLAGQWRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TJS0</accession>
    <name>A0A1Q5TJS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_7918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000647">
        <property type="protein sequence ID" value="OKP00461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TJS0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TJS0"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012841063" evidence="4">
        <location>
            <begin position="22"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="108"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="380"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP00461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="473" mass="51132" checksum="085586D3CC8BCA87" modified="2017-04-12" version="1">MKFTFYFHALGLLGLSEVAFAVVAAASSSVKINTGAKLQHVDGFGFSQAFTRAGQFQAADPAIQKQALDLLFSKESGAGFSIIRNWIPSSFNYTIEPNSPGSASAPPQYRWDGWDEGQLWFTKQAVSYGVKTIYADAWSAPGFMKTSGNEATAGYLCGTPGHYCATGDWRQAYADYLVQYVKFYGNEGLHITHLGFLNEPDYQPSYSQMQISPNASEAISFIPVLRKTVDTAKLDVSITCCDATGWDKQSSYTNALVAAGMERDLGVITAHMYSSDATYPLNTSLPTWLSEAGVETNVGGFVPTWYNTGALNEGLSWASKIAKGFVDAGLNAYLYWEGFEIAQQQSASHLLDTTGTNNTVVLQSGIFHAFSMWSRFVRPGAHRVETSGGSNLANVITAAFQNQDKSVVVIFTNTGSADQPTDLVVPDHKAGGSAKAWLTDNTHKVERTSVGRVRGGSIQVTIPAHSVVTVKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TKL3</accession>
    <name>A0A1Q5TKL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000643">
        <property type="protein sequence ID" value="OKP00767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TKL3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TKL3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP00767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="283" mass="31525" checksum="4432A6E3E756D661" modified="2017-04-12" version="1">MVNVPGRSKGCVTCRKRKIKFTAALFKSQQHVFSSQDWLRIPFEVHSKTAFDEFVDILLSLLPCLSVASEMIDSADERADQLKTKLTKLVGALMSQLHVWWTKCICSTNFIEANAVQWMGTSRDGFQDLYGDPEHFPLIPYVDMPTASLAALFHAVNVIILRLSFVVSPTANLYENRIQRHVKSILLAKDFVATFPSPASSRGSVMVGLPLKIISIWSPPEMGLSAEDLLPGLDGQNEDNGSYSISSRELFGDVASYILQRYNPGGSRMKNLGREHNYPLLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TMB4</accession>
    <name>A0A1Q5TMB4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">24-methylenesterol C-methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_7358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000639">
        <property type="protein sequence ID" value="OKP01368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TMB4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TMB4"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP01368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="229" mass="25901" checksum="2F6A5F6C5E83DC9E" modified="2017-04-12" version="1">MSDTPEGIIEYTYDKIAEQYLQWVESQTLLRQRYAKILLDKLQPSPSILELGCGPGIPIVKMLLNEGAQVVGNDLSTKQIEMAKARCPGAKLIAGDMTSLTFEPATFHGVISFYTLFHLPRSKLKAMLTEIYGWLKPGGVFVFNLATFDEEEIHGEHLGYGMFWSSYGVDENRTMISEIGFDVLQEDVLSEEVLPEEILQARDGKLEETDSDDAKFMWVVARKKELQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TSL4</accession>
    <name>A0A1Q5TSL4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_6904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000619">
        <property type="protein sequence ID" value="OKP03200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TSL4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP03200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39690" checksum="D9557C2F971615E4" modified="2017-04-12" version="1">MSSSQDRDRFTNAMGVSLATEARICCGTTKAGAPCKNSIKSQDIKAGQQQLANLATQPFDFLTLRSTLCDIARNFLCARWHRQRQADQLGQQWYEAVVRSREHARDTCEVAAVAPDIEADQSQRSTFGRPSEPVLSSRVTTQHEDESLSPVRDPVPLGPSERIRRYVTASMLRTNSAPWCISPAQPATLSGFYIGAGMQNLELHSLTLSDEVSAIYCPFCLGDDEEHLDESVILRCNQCRGLAHLSCVEEWLEKRDAGPHVSCCACRSDGALDALRRSPRARANPDPACEDAETHAALVVERSDTTDSPQQTSSDRLPVQSVPSRRRRALSSTRRSVRRSARLAENNTPRRSPRLNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TVK9</accession>
    <name>A0A1Q5TVK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Extracellular metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_6765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000612">
        <property type="protein sequence ID" value="OKP04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TVK9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TVK9"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013384561" evidence="9">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="220"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKP04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="314" mass="34296" checksum="80AD0C962F6450CD" modified="2017-04-12" version="1">MVCRSLAPFVVLVTTLFSLQVQCGPVVFEQRGICATEDPDTSFLDALQRVRTDETQLPETGSEARNGPIEIETWFHIISSKAEQDQVSDDMIDSQISILQDAYQDAGIQYRLQGVTRHVNDVWARNGDDTGMKSALRKGTYRTLNVYFQTNLQASPDQAGRASHRGASHSSDLSSSVLGFCTLPDPSVNATSPRADYIKDGCNVLASAMSGGTLDLYNRGGTAIHEIGHWNGLLHTFQGESCAEDNPGDYIADTPQQSVPTGGCPARKDSCPGLPGQDPIHDFMDYSSDVCYESFTPGQNERMRNMWASMRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U1A8</accession>
    <name>A0A1Q5U1A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000598">
        <property type="protein sequence ID" value="OKP06247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U1A8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="188" mass="21646" checksum="16F6DD742B90BB04" modified="2017-04-12" version="1">MKDLRDSRNFVRQERKYEKFAIPLRDLEHKLAHEYCSPLKHEIIRCGLTPGESSFMSMVLEDNPYCIWRDIGFMPFNGVSNPPFVDYILDQITTADHEGEAMEAFAYVDLLRGLQSSIPHVHDDEVCDMLSLFHRRYAEAFGTPYRREFVSQEVATLLPSKLHSNTSKSEFARGIISLRRKDGDSAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U3D0</accession>
    <name>A0A1Q5U3D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_6171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000585">
        <property type="protein sequence ID" value="OKP06988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U3D0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP06988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="12833" checksum="0C989DD34DB8011E" modified="2017-04-12" version="1">MPAPDKFLGAAQDLVLTLLPTSSTAERVQQPVLLQQAPTVVAEYVRVSLQTQTTVALAETSVPEIASTANVTVQLRIRSVLRLEIAARPATHVSTVVLAQDAATTLNSVRLHLSPAVPLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U4K7</accession>
    <name>A0A1Q5U4K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_5998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000582">
        <property type="protein sequence ID" value="OKP07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U4K7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U4K7"/>
    <dbReference type="OrthoDB" id="4971611at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20323" checksum="949617684AC89BCF" modified="2017-04-12" version="1">MPELVSCVSAPTWDATGPQTPTQQFFKKYVDTVDSYGFNHGSGLRFYSKDVIFHNQNNALYNGGDEMWAWMKRLFGQFERLRHDFHSLWEVKNEDGTTTIMTQWTRNIWLSGNDTEEPTVSIPLSWISIIGPADFADAVDGLNFKEVWLYWDTALLMKHLPQEAVVFQTQNVLHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U5E9</accession>
    <name>A0A1Q5U5E9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_5816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000579">
        <property type="protein sequence ID" value="OKP07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U5E9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U5E9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="184"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="714" mass="80121" checksum="4E789E9C791D2B5C" modified="2017-04-12" version="1">MDSEYSRLADTIRQQASEHSKPRYLVAIAGVPGSGKTTTAQAVVQQLNKDLNIHAAPLPMDGFHLPRSALDQLPNAQEAYIRRGAPWTFDVSRFVKFMHDLRIWSDKTPLAAPSSQTIHAPGFDHEAKDPVEDKIVITPDTNIIIVEGNYLLLDEPGWRDLADLVDYRVFVDTDLQEARDRTAKRHVLAGIEKTLEDGYRRVDSNDYLNGVSIREKLIGPDLVVKSETDWKRHHLAPISGSIDHQESPLTAAWREINEETSLTPQDIELWRQGKPYSFSDPSIGRQWIIYPFAFRLKGREEGGKGEAAIKIDWEHEEWEWYDPKEVVDDEHFGGVPRLAESLRRVYFELDMNDKARSALQSGLELLKTDHSSGSHELTTLALKAFRNVLVHLQGHTNWWETTRMAAWHLWKNGRESMGSATLNAFLGVLADIDNIKTRRPENQWDRILTAVDHHLERRRETASHINEAFTAYLDSDFLPKIQSQGKDKLTLLTLSASSTIRDSILDAFKSLPVSHLDLRILESRPLFEGASMASSLLLEFECKFSPSSGQHLQISVHTDASAALAVKDVDFVLLGADRISSSGSVSNKTGSLPAVLCAKHISPEAKVLVFSGLEKVAEPGTEDDHQPEENNPIEVINPWVDTGVKGVGKLQERLRGTKKETSNCVVEVKNVYFEWVDANLIDAFITEEGAMGATDIHNKAQEVQQKADKYFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5U9Q8</accession>
    <name>A0A1Q5U9Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="5">PARP</shortName>
            <ecNumber evidence="5">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="5"/>
    <dbReference type="EMBL" id="MNBE01000557">
        <property type="protein sequence ID" value="OKP09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5U9Q8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5U9Q8"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="453"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="685" mass="77932" checksum="BD1BA038278EF5DB" modified="2017-04-12" version="1">MTPTSFAGVIVAASGNIPGQTHDSIQRMVEECGARFEKLKVSDCTHLITTKRSVQNATRKVDAAHKVVHCNVVGIEWLVDSVQNKKPVSTDGYLLKPTPDNVPGGSQLTQSSPDKPKSNKHKLAADTHTIEEPPKVQRNNLHVHREQLVFLVDDHFQTRGEEVAVWMDEHGVRWDALLISNLIKRPSSQLNAYTPEYSVLIHRLQILYIFKTDRYYTWFRLVDDKTEEGELYGNGDLMSAVVEFKRLFKRKASLGWEDRYLLPQTLPWHFPDETRCLFIQPPTEDEQQTIAQGHEKSKDMIKIPDAIMGLIKLLFGHTNKMQTQYLFNEIANCRIKAIGNIQLGEDALRTAIALLDKLGHALTDHALTDHALTDHEKRKALRSSLSPHSTLGRAKYLKQCYFGLLGIVNRSITESLATDQDWLKREREDVHLLLKLRIAIERAHLLYNNPLAPLSQQAFQTLELAEIKKVRKGTKEYKGLYDYLQSSVGSLHTVQYKEVINIFRIERRGESERYHKWRAANGDKIGQRYLLWHGSACEKFIGILSQGLRANLFEKSAGGMFGAGIYFADMSGKAARYCRGPANMALMLLCEVEIGHDPLILEDCDRNAASTLHKEGKIAVMAHGRSNHIGWNNAKKLHRRLDGVWMPDVALPREHRASKTLAYNEYVVYNPAQVQQRYLFHLKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAC3</accession>
    <name>A0A1Q5UAC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rik1-associated factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_5236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000524">
        <property type="protein sequence ID" value="OKP09414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAC3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAC3"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1138" mass="123896" checksum="DD4EAE1AA7B58587" modified="2017-04-12" version="1">MPHHSIYFTRGIPRSTVPAFTGDSKQVVHLEALAEQLYQQYTFGLAQSSTSTSNGGQETGNFVTHGHTMFEQRDDLGWVPHDDDVVGEVALVTPTFTKPRPTNICLSNGVTSLSASAPSKTVRSVPPVDTTASTVVNMNVSAQGISTSVHATVPPQETPAPVKSAASPQGIPTPATTTSPPQKTPTPVDSTSPAPKTSVPVDTPKPAQKTPATVTVIKPLQVAPQAPRVSREKASKAALPASARKEDLRRSVALLNASRTHEKTKPATQVTSQAHIKATKTTTSLHIPDSQASMSSSEYRPSSPSSQSSRSPTPQSPPQATSPGTRRSRRARAEPVTYNLKTLSSKIHDSPNQSERENSPAVSRSPPPTASPRPLLQLRQPSQACRSSQGRPTLQDFPKEIQEPPDPEKDPKLAKPKLTKLLWARELQGAKPTHDLVRSLVSSNLKPWKTWKGASGDVSALAWSPNGGKFVTGASAKSDVYNRRNTLLFGDISRNVLHELPDHNIPQTINATTADDLQFPTVSTVKWVHRQLYTGSYDHTVKVWNTDPITSPVTPTCLATLRHDSSVRVMDVSEFMPHLVATGTESSFTLWNLLDQSLTPEPLQIHRDPRQKANVVLEPTVLGWGQNEATKHYLVGGMTEAATSEFKVPLCGHLALWRVTEASIEPCRVRPDSQNIFDLKWHPTLPRFAIGSTYSQSMNLPLRSKSVVQLFDIESDGRAVVTGKYACSAMDMNEVTFCPMDSTFLTASCTDGSTYVWDSRFDSKPIHKLSHGNSVTPLPAGHSREVTDFGVKMALWGTTMDQFYTGGSDGVLKQWDIRRATEDALVANVANLGDGITSGAFSPDKSQLLLGTNGGAVHVLSCEHSEEEAVDFDFKHAPEPPSSDAPGILLAKEYLSSGQLILHPVFGPVQGPKYNGPYAPWARDLPETVTNEKLKRTPLLSEYQLRQFDGPPLDERRGLDPKVRREVQSQFNLARARHARRGGPGALLNSGDNALKRKRDSLVEFGGIDKDSQARKKRKKKKDKLRKHRKNSHVITRIEESIIDLTMDSDSELVTATSVATPVPVPVPVTTPMTAPVAVAAETDDLTMEASVELLEGSLNRALSLSPMLKVLDEESDGEDYWWPDSRLVDANLAGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAI3</accession>
    <name>A0A1Q5UAI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4321</name>
        <name evidence="4" type="ORF">PENSUB_5140</name>
        <name evidence="3" type="ORF">PENSUB_5159</name>
        <name evidence="2" type="ORF">PENSUB_5161</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000511">
        <property type="protein sequence ID" value="OKP09483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000510">
        <property type="protein sequence ID" value="OKP09491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000508">
        <property type="protein sequence ID" value="OKP09518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MNBE01000370">
        <property type="protein sequence ID" value="OKP10275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAI3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP09491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP09518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="151" mass="17050" checksum="C288D78442099130" modified="2017-04-12" version="1">MNGILASRDAPFSNTEQQSIGDPAIADWETEDEEGIDPKSHPEVITTLFERKAPDSPSHPKLLLTLSLLKSKEKGQTFDNSPSVVRRTMIAEEDKYSCEGSIRQDMLQERKQNANLYFQGGKNWPRELHNYSDLKATRLELPANSQGSKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UAT5</accession>
    <name>A0A1Q5UAT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_5014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="MNBE01000483">
        <property type="protein sequence ID" value="OKP09582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UAT5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UAT5"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP09582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="505" mass="53762" checksum="3E0EE50380DB49A5" modified="2017-04-12" version="1">MSLLREAERCLANQHAHTLNAFITPLPRAGQWLDRVKEADQRREQGNPKSAVDGRLISIKDNICTRDLPTTCASGILDKFTSPFNATVVDQLEAAGAVIAGKTNLDEFGMGSHSVHSRFGAVKNLRRDADGRDLSAGGSSGGSAVAVAADQCYAALGTDTGGSVRLPAAYTGTVGFKPSYGLLSRWGVVAYANSLDTVGILGKKTSSVRDVFSILNKHDSRDPTNITSSSRSRILSRLQTPRLASRLTSTPLRIGVPLEYNISELTPSVRQAWLLSLAHLQEQGHTIHPVSLPATKHALSAYYVLAPAEASSNLAKYDGVRYGTRSDGPDSDGQPDGYLYANTRGNGFGAEVQRRILLGTFSLSADAMDNYFIQAQRVRRLVQQDFNAVFAAAHPFAAASDAVEIDRSTTANVDVIVCPTAPSPPPRLSDVSAGSSPLDAYVNDVFTVPASLAGLPAISVPVTVAESERNPDADEVAGIQVIGQYGDDELVMNVGELLEGRRLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UB61</accession>
    <name>A0A1Q5UB61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_4986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000474">
        <property type="protein sequence ID" value="OKP09715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UB61"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UB61"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP09715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15054" checksum="E3F4708503DF3C6F" modified="2017-04-12" version="1">MVVLSDYGCSTSVFANAPSDCAVSRGTLFNANQSASWHELGLFTINQNGAGLEANLGYDQRADFALDTLSIGLTGPTLKNQTVAGIATPEPFYLGVFGLNPQPVNFTSLGNFSSPSFLTTLKDEGTIPSLSWSYTAGAKYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBA5</accession>
    <name>A0A1Q5UBA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isonitrile hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000462">
        <property type="protein sequence ID" value="OKP09753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBA5"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBA5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="78"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP09753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="237" mass="26204" checksum="509D1FF5230F61B5" modified="2017-04-12" version="1">MAPIHLGILVYDYQAIDVVGPIDLLHSANSAFLEVSKMFGPVNDDAISQAPDFVFHHVCITKEPFHLFTSAITLTSTTTVDQCPELDIILLGGPNPEGFKLHPKYIDLIRQHINAGKLLFTTCTGSAVLASTGLLDGKNATINHAGYKWAKENYPAVNWTKEKKWVVDGNIWTGAGAVAGMDMVACWLKEQFGLEILTYAARNLDYEPRGVDGVSPVIPRRYDESGKQISTHEFFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UBN4</accession>
    <name>A0A1Q5UBN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000437">
        <property type="protein sequence ID" value="OKP09895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UBN4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UBN4"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP09895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="334" mass="36601" checksum="FE81B5A12CACCB63" modified="2017-04-12" version="1">MTVSPQIVTVFGTGNQAGAVARALLADKAGRFRVRAISRHPDSKSSKQLVIEGAEIIHADGWNQDELTKAFTGSWAAFVNTNSDDPQFLAPGNGPTEFDLGKNIVDSLIAANVKNLVYSSFSSSMKQTNGKLFIKPQEMKYQALEYAKSCGHFEFHCGIYAAWYYEQFLDLPTAEVGGGFPSIPDDEGYLTLRVPVWGSDENPSFLSIGNDFGDLVHGILLDPGKWNGKSIPAVSDVMTFEQLTNVFQKVTGKKSRYVPLSSWEDFGRGIPEMDDHRLLFAFTQSTGGRYFGDVPTETDTANELKKAAAEAQGKVGSRAGLMPVEEFFKIHFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UC86</accession>
    <name>A0A1Q5UC86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_4552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000398">
        <property type="protein sequence ID" value="OKP10087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UC86"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UC86"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000025">
        <property type="entry name" value="Hexapeptide-repeat containing-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF77">
        <property type="entry name" value="O-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKP10087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="221" mass="23720" checksum="A08677D17E1587F7" modified="2017-04-12" version="1">MIPKVDKDDVIIEEARGLQGVCWGEEYERMISGMLYSPLAPELIEGRSRARQLTGEFNASLYGDVASEKTSLQRTEILKKLFGRTGQSIYIEPPLFVDYGCNISVGESFYANFHLTVLDCGLVSIGNNVEIGPNVSIITGEHYTMIEERRAHRGHEFTGGVVIGDDCWIGAGVIILAGVTIGSGCTIGAGSVVKADIPPCSIAIGVPARVIRSAKQESTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD04</accession>
    <name>A0A1Q5UD04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_4256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000358">
        <property type="protein sequence ID" value="OKP10339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD04"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="73"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP10339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="265" mass="28048" checksum="DAE5ACCAB93C88C6" modified="2017-04-12" version="1">MPGITTPGNRLWAEPHSRGPWSLGQHLARQLANILPADPSAGLESAGRGDGSGFPGQIIVQATDDALTAARTIQPGSAIWSDGSRLENGRSGAGIAWQEPCGEWRARSFPLGKGREVFDAELVGVVQALQAALKMDDSVPITILLDSQAAIARLRHTQAGPGQELTLRAHAVARALQEGGREPIVQWVPGHAGIEGNEKADEAAKLAASRLASSKPLATRFFQLKSGHAAIGAHLHRIHARDSPACEKGDAPAETVHHVLFECRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UD80</accession>
    <name>A0A1Q5UD80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000337">
        <property type="protein sequence ID" value="OKP10446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UD80"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UD80"/>
    <dbReference type="OrthoDB" id="3220769at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="468" mass="51829" checksum="CD96E1C82737D34E" modified="2017-04-12" version="1">MPSIHESFFSYNVTRPYPYRWFTPVAVLGGVTFAALFSLLNFAANGYDLVVQISTDPNSTMSSAGWLGRWPSYFTDKVRPTCQPATVPVGSQMFTNQTSLTYTLTAVWQLSDGTNSTALPSMSYFNNVLENCTVTAIEINLEALDRTASQFGFSEWGAVVQTYVLCGFYTPSGLIQFNLTQAYDYIPAAMSWSHLYTFLGTNFLGRDKSTRASLWWGESVLSNYYVYLTRTMQDIRANATHNDEPGIRKGTIYMTPGNSIARDIKSLQFFNIDYRFIVDLGYGNFEVLSPGEDPSVSKLDQGRVYPDVWIIADSLAKSAYSTVLTDLGQIAAGPNLLTNADDLEYFSRNFSTIQRHKANADPGPEVDMYYGTAKNGTGPLGTTPSVISLGYICQVPRLKSTGNLLVSILVADLVFLQAAWRLFKLATDTYLFKSRPESNQCKVEEAHAELDKADGVTSSGFNLESNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UDC5</accession>
    <name>A0A1Q5UDC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_4110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000322">
        <property type="protein sequence ID" value="OKP10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UDC5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="177" mass="20214" checksum="52B806605E0A7BDF" modified="2017-04-12" version="1">MDTSHARPVGDHPEDQPANYHPPTGEPAPENQDNPQMAVDPPSDPPAPEEPQRPPLMDQPFEPAMEALARLEREDPKLAFQAARIVGLYRRLWESCTSKHIEGSKLAKANHGLRETHRHLTDERNKMQLHHDDQMARLQFFDQALESSRLRLSDILKDWDRYSEGVLTQSTVNDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEB0</accession>
    <name>A0A1Q5UEB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000310">
        <property type="protein sequence ID" value="OKP10808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEB0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10107" checksum="55103214010E8402" modified="2017-04-12" version="1">MSSSSSSIQGKDNTITNVSAVPETHDGSEPVRDISGDVIEDGLRRGLKGRQFVIIALGSIIGPGCFYGLGYGIYEAGPLGLLIGFSVVGMYEGAGNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEV0</accession>
    <name>A0A1Q5UEV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000309">
        <property type="protein sequence ID" value="OKP10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEV0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEV0"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="301"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56102" checksum="7A7C81B20E78DB3E" modified="2017-04-12" version="1">MSVKRVLVIAGSDSSGGAGLEADQRVLAAHGCYALTATTGLTAQNTLGVQDIFVVPPEFVRKQINAGLEDVGADVVKLGMLSSAETIDVIAETLQAHKVPAIVLDPVMVSTSGSQLLPEKAVEGLRFKLLPMTTVLTPNIPEAQLLIKDSGSEVPEPADISEMIDLARRICSLGPKAVLLKGGHLPLTKDHKVAKSPEESTTVIDVLYDSETSTTTLFETDYLVSKNTHGTGCSLASAISANLAMGKDMVRAVRSAVRFVEAGIRTSVDLGKGSGPINHFHSIYTMPFAPGRFLEYIMDRPDVQGAWEKFIKHDFVEGMGQGTLPVERFKEYLVQDYLYLVQFARSNALAAYKSSEMDSIAASAQIVLHIQREMALHIDYCASFGLSKQEMEASPETIACTAYSRYILDVGQSEDWLALQMALAPCLIGYGTIARRLHSDENTLRQGNQYWKWIENYVADDYTEAVRLGSALLENHVQKVSPSRLEELIRIFMRATELEISFWDMGLSDQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEX3</accession>
    <name>A0A1Q5UEX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Noranthrone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_3534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEX3"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="196" mass="21064" checksum="BAC1FC7F9885427F" modified="2017-04-12" version="1">MAIFLDNISPAKATLLCGTAGIVSSSVFYCMNTTINYLTFPTILLGQPPRPGSKASGNFFVHAMDVPASSVSHLNRQWQEIYFRGHRIGPALAIIGGTVFSTASYLSDQVFVKQVFAAATISSFAIVPYTLLFMLSTNDELHRRSFAIVKDPLASKNMDESETAALISKWVALSKVRANIALLSACLGVVGIIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UEX6</accession>
    <name>A0A1Q5UEX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000308">
        <property type="protein sequence ID" value="OKP11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UEX6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UEX6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="200" mass="22194" checksum="760123893BF872A3" modified="2017-04-12" version="1">MGVWQNAKLLADQYAARGYLCLVPDIFLGDPVPINRPDDFDVKKWIMQGSDGSSPHTSNIIDDIVKRAILYLTSQHGVVKLGAIGICLGAKYVARHFSSGIAVGFIAHPAFMEEAELENITGPLSIAAAENDYIFTTEKRHKSEEILSNKTPKVPYQVCLYSGTTHGFAIRCDRSIPEQKFAKEQAFLQAVNWFDEYLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UF46</accession>
    <name>A0A1Q5UF46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000304">
        <property type="protein sequence ID" value="OKP11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UF46"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UF46"/>
    <dbReference type="OrthoDB" id="5130616at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="1">
        <location>
            <begin position="61"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="476" mass="54374" checksum="A149B1AE0BE48B02" modified="2017-04-12" version="1">MTRPFQLPNDVLLLVGEQLDNHADRWNLIFISQRFHDLFLSLVYRTVRLNHWRDAYSFICAITKRPSLARVVRELDLSRWRKESIPQADWDVLQRSSILKGRLEVSSYSQDETAQWVEHLAQGRGDTWSALMLPLLTQLWQLHLVYSIPSICLNRIMQRAINNERPFQSQPAFQHLSKVSLHHREDLDRPTAHVNAGNGSHEDQSALLLSFFQLPSMRSVFANSVVDPTSISIVPDLETEETEQVSVARSSITEIDLRRSSGNRGMDALIATCADLKSFKYQHSDSHLTSHGYQPTAFYRSLTRSKRSLQSLWLDHYGDHYPFTSAGLNQTHDEWFGSLADFSALRELRIRLANLLDIRYQSEPISPLINSLPGSLEILYIEGCEERHMGMLVSQLRTVIRNRRSQFPHLRCLNIEGSFRNASADELGDTSASAPEPADDTIKPKIVQAAEPLHEDCASAGLELHVYDRTFSQKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UFB4</accession>
    <name>A0A1Q5UFB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_3335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000294">
        <property type="protein sequence ID" value="OKP11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UFB4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UFB4"/>
    <dbReference type="OrthoDB" id="4368338at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="287" mass="33302" checksum="A70A887A9D102C4B" modified="2017-04-12" version="1">MLALQWIQLFNKLTKDSAKGTHRMLLCDQFGSHLTYEFVKNCEDHNIILFFLPPHSSHLLQPLDVGVFSAYKHWHSEWVYDATVSGYEKITKDDFLGAIAQIRQKTFKPATIKLGFRLTGRWPINPSLIIDSLVDSGRDFGYNTPSPLSSVASQDSSDLSTPKTTEQVKRLEERLEDKIDRMQQPSRRLIKKLSKAATDFAHLVAELKQNIENSEYLREQRYARENRSRKASKLTGIVHSSQVDRMKRIVKRGDDLRALMKLRPYYKREVMPELKRVCKAKGYFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG11</accession>
    <name>A0A1Q5UG11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coenzyme Q-binding protein coq10, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_3107</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG11"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG11"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000048">
        <property type="entry name" value="Sreptomyces cyclase/dehydrase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="98"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="195"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP11415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="269" mass="29163" checksum="4A64D7EE8612D095" modified="2017-04-12" version="1">MRPTCHPRLPCRTILSSTRPHCPAQRTLPRKQPTPRTLSTALTRRAIPQTTSPVSNTHHTQKRTFGLPSLSSFLPSSPNGNGGNDSSSKRVLTATRTLPYTPALLFKVISSVESYSQFLPFLNESTVTARDPKTGYPTQAFLTVGYGPLSETFTSRVDCDPATWTVEARSGAKYGDGKAGGSGSGLSSFFPGASEGIFEYLSTRWELVPVPGAGGEGSGLPQTKVNLEVRFEFRNQLHATVMGAVEGQMASIMIEAFEKRIRESHTRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG17</accession>
    <name>A0A1Q5UG17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_3094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000280">
        <property type="protein sequence ID" value="OKP11402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG17"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG17"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="866" mass="96749" checksum="B8FCDAB2CA1865AF" modified="2017-04-12" version="1">MAQALAGSEQAPQQLVEDALPNSVIPEQRILSLFERVITTNAPILESLLLQVPTDTILALYHTSHYLRTFLQSYPTAWKSLSFRLLCPSGTLPATRIIIPGLSDQEPQRQSRPYALDQLLMNVVIPFSGCLRSLELDNTAVSGQILISTVLHARRQTLEHLSVRGCKNVSLKYHVIPYLTMFGLQYDVDMEKNIGSSPAFQRLALKSLYVYRCRHHRRRPYLSASLLRKDSDSEPTHDLVSLCHKLGIWTDTAWCTTPAGRCFRRRGYVSMRVPQGSPEVWVVFDRLWRCKNWIGPVDSKTERPRVPDGKLWENCDTGCHGEALGTGEGPDVGEGKMTPAHLRHSHTQFVQNVKCDNCFDDISERCEQCSILMHCVGCRRTLCASCAYERPYLHRGASATYSGTNSNSDSTNSTSLWWAPGATLSPSSMQDPVSNPMDNGVFHGGAPTSHPALKFHWCCTEPIFSGGGGISIGTPSRDVDQVRAVPLPRGQGWEDLEYTVSEWSKTFPKYAYGDPSKPDYSLETGHLAMMKWLLGPPNRQVSPCPRNLCQECYDSPQWKVHCKSCSKPLCIEHDLRGLRLRICGYRDLAFEKMTIQTRSAAHLSPDASFSQQLPGYDLPFRTHRIIDSANSSFIDDPQGNIVADDTELDTPNVEGSSHPLFSRNATRSFSAPPSNHSGSCSPTSVSSESPFEAPRWQGCQSFFCPQYRAVGDQRQRCPSYLRECKACAVYVCQDCVQAHPPCKCSYCEENYLCPNCMKVRARDGTCRRREEEKARRERKWKKDMQVLEGILELKVANEVAEFAGQFFDLVELDTEGGIASCLMDDTESEAAQPSESQVLSSGLNTDVGSSTMFFADSFTGARDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG69</accession>
    <name>A0A1Q5UG69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2 Q2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_2963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG69"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG69"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000107">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="706"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="853"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP11477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1131" mass="126126" checksum="CD81631A5F7EE84B" modified="2017-04-12" version="1">MPTRHFQRDLNEATTLGQFPHITRVRAGEGDGSISFTYTDTGAGDTFHFEAIVPDPHDYPSTHTFFVYSTSDNVPSEITRAVDEIVPRFEGSSINDVLSTLDCVVSDVIQGCTPQSSEDVDDIAMSSGQEFGDDIELSDWTDDEDSFFASTENPDKVLEKVRRDLRAAKLAGFKVGYHGNPAGLIIVSLAMRIAKMGISEEAMSAWNVRPAEYLVLLIRYSRYQTMEDLYVSGDSKIQMRVGLCDSYKPSFASTTKAFQENFTPRDQSRQSKVEDQDPGPTLRGLFIGTALDKLLNEQYLHIVRLRLKHGFSWTGAETFFHAGQGKFIGPDDASSPEFALQDTWITPAPGFMQTDPVADMNLTPSDISFPLLTKLFLLRHFVKCTEFCLVCHCKTNDSFEALKPYVCSNGLCLFQYMTLGIGPSLEYEIRTQPYVVDMLVSLAYARAKSGRLTDFPIGLGLHVPNMALLDAESTDPYGPHNVVTLSTPHDDWKPSTSYEAKLSGATMELSHKFVPKVKVGTWIVILHPETPVAAKEKTQAPWHCRVQRVGETSGHITLSPPLVRGVQLSEKEVLNRYPVSAPIRYVIYDTNFDVLSEDRRRRTIIMLLATLPNVDSMLAFLGDHESGKLLSSWHEMITPAALDLLRWIVASNRSCILQDGRHADHLVSAMDGYLQFRLVQGAPDKEQRFMEAVNRHALRTKPAWPTIFAWHGSPVHNWHSILREGLHFKAIANGRSFGDGVYLSSHHGTSFHYGGYNAGGSWSQSKLKIQSMISLNEIVNNPAEFVSTNPHYVVNQLDWIQPRYLFVQVGDTSTLLETSRGTVPSAVYEQDPAHQVYGPENKVVQIPISAFSSKRRQGLTASPRKPKPTRKKKRNSKGSPIPMEFDQFDDTASICTDIEDLTILLSDTEKEPDQVSSKKKKVDTVPKTDFIPGTLREASLPLMSPPAYATTPATSLLQRNLRATLKIQENEPLHELGWYVDPSLIKTVYQWIVELHTFDPSIPLTQDLKAANLTSVILELRFPPQFPMDPPFVRVIRPRFLEFAAGGGGHVTAGGAICMELLTNSGWSAVTTMESLLLQVRLAISTKDHPARLAPHGRNYDYSVGEAVAAYTRACRTHGWAIPKDMQALSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UG81</accession>
    <name>A0A1Q5UG81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000277">
        <property type="protein sequence ID" value="OKP11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UG81"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UG81"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="258" mass="28762" checksum="4EB342F0C15D25CF" modified="2017-04-12" version="1">MAQIPTPPPSRPGSKASDPVPKSAEASSELLQSLDVLLEQYLHLLDRQQKLQSGLAKQLSSGFLSLAHANYTCPPGRRYGADYYDERMKATRKISIHAGSEVDDEDTTEEQDGADSCHPEKFEYIFNLEKADNRPAEENTDDKDAKDEPYTKATETEVSTNDSEPYTPASQDPTGEPPVPEKTKSVRKKFHSDDPIYWYGILVPPSLRTAQKSFTEAIQSQVPDLAGTIVEMRALEQKITQVRAKLGVDTSQETRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UGR3</accession>
    <name>A0A1Q5UGR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">PENSUB_2711</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UGR3"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UGR3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OKP11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="507" mass="57618" checksum="8EACA730F71A730D" modified="2017-04-12" version="1">MGNDDQPKTYRYNETPVYTASNGCPVMDPQAAQRVGSNGPLLLQDFHLIDLLAHFDRERIPERVVHAKGAGAYGEFEVTDDISDIVSINLLGTTIIDMLKGVGKKTKMLTRFSTVGGEKGSPDSARDPRGFAMKFYTEEGNWDWVFNNTPVFFLRDPAKFPVFIHTQKRNPQTNLKDATMFWDYLSTHQEAVHQVMHLFSDRGTPYSYRHMNGYSGHTYKWIKADGTFNYVQIHCKTDQGNKTFTNEEATKLSAENPDWHTQDLFEAIKRGENPSWTCYVQVLSPEQAEKFRWNVFDLTKVWPQSEVPLRRFGRFTLNKNPENYFAEIEQAAFSPSHMVPGVEPSADPVLQSRLFSYPDTHRHRLGGNYEQIPVNCPLRSFSPWHRDGAMNVNGNYGANPNYPSTFRPLAYKPVKASQEHEKWTGAAVAEQIPVTDEDFVQANGLWEVLGRQPGQQENFVKNISGHLCGAHERVRKATYGMFRRVNKDLGARIEAATEANVAPSARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH06</accession>
    <name>A0A1Q5UH06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prenyltransferase alpha-alpha toroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000274">
        <property type="protein sequence ID" value="OKP11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH06"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UH06"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="3">
        <location>
            <begin position="122"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="174" mass="19048" checksum="E452F688C783F264" modified="2017-04-12" version="1">MPPIIAGRHKRKVRFPAANLPPAIISTPTTAQQRHTETKSPSDLKPGKSSKSKPITASGMASQEEPRPGIPALFTQPPPIRDPLVTETIQLQDATLNKCLTFLKGLHISQQGTLNASGVPALQRDGHAVFLFESLEEEYPAGFVAMDASRPWMVYWALAGLTLLGEDPTRFRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH13</accession>
    <name>A0A1Q5UH13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000273">
        <property type="protein sequence ID" value="OKP11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH13"/>
    <dbReference type="OrthoDB" id="4361389at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="238" mass="26739" checksum="F09360A28019CA69" modified="2017-04-12" version="1">MASSNQRSSPAMSHSSAGTKSPAAQHSTVPLDSSRYASAMNDSDQPIELSGPDHKPAFPPKYTKRPPSYSNSTSQQPSAETYSSRDLGTGRLYYHNQGPDEHRPAPQFTQPQQEYYRPQPPRQPVQPNEHQPAHYAVREQYYHGGQAQQPPAQRTDDYYHAQPHAHAQAPPQQYYQERGQSDYYPPRQSVDQQQYYQAPARQVPQGGAQIKIEPDMIDQLISRATPEKQNVGGKSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UH76</accession>
    <name>A0A1Q5UH76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_2606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000272">
        <property type="protein sequence ID" value="OKP11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UH76"/>
    <dbReference type="OrthoDB" id="4423022at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012072736" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="11842" checksum="C287BFF594FF2599" modified="2017-04-12" version="1">MMNKIVSVLSALAVVAAANPTVGYAGYFYTNCTAPSVDAANAYAGSCINVENFPIKSFSAYVEAGSCADGTSTVLNTYTASGCDDSSLFGTFSVDGEKQCFEADVTLVSLKAECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHF3</accession>
    <name>A0A1Q5UHF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000259">
        <property type="protein sequence ID" value="OKP11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHF3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP11892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="157" mass="18244" checksum="6C9BA712E92ADA2F" modified="2017-04-12" version="1">MVPRFIRTRKSRKAGESKEWNPATFYIVMFTLIGSQAIRLLTLKKGYAAYRRSADAKIELLKEVIERVQKGENVDVEKLLGTGDEGKELEWEHVLRQIEQEDAQWHSKQKAEKEKEKEQKQAMQELEKKESASVVPDTTSEKDATKKTQSTRKVNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHJ0</accession>
    <name>A0A1Q5UHJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD and RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_2507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000255">
        <property type="protein sequence ID" value="OKP11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHJ0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHJ0"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="664" mass="73271" checksum="5D338B7D6A73D3A6" modified="2017-04-12" version="1">MSDTCIVCLGDLGESASDPLAVEPVPRLHLHDGADPTAKAPTLGDEEGSGEIAQLLPCGHILHNVCLKPWVERANSCPICRRSFNMVELSDRPGGPVTSSYAVQDRVQVAEIDPSMVIDYVEDDFLDYQPCTICGESDNEDVLLLCDGCDAPSHVYCVGLDEVPSGSWYCERCEVQRALEPTTEAPARPSRTNERRTRRTRGQQRQAQSRNQINSLHWARVWQSVWDHLNIDLDFPFDDDRSAQRVLQQRRREEANQREFRAWQRRFEVAERQGGGSRFRDSASLFDIEPARPSRPRVPRNPTPEPESLEEMRAWNAFERAREIENNPSAARKRKEPTLSPSPEPTEPQRKLKRPRTRRPQELAAMAQQNGESSRAASASASGSGTNSNVSNVNPNANAGVNLSTNANARVNGDASGEPSFLSSLLKEVEDASTTERTTPLLLSAPTSIAPTDHVSPGPSSPSISPVSSNHSSPRLSSTTPPPYSRSRPISPFQLSSPVEPSSPPFSPEVSFSGSPISPSANREKPTAQRETNRPRSRIPRRVVESSHPPSADTSPTRAGPSLAVKVDIRGMVSMALKPHYRSKTISREEYTETNRTISRVLYDRVGTVETLSAEARADLENTANFEVQKTVGAIHKNNQVDRQKQKQKQKQPMAAADSDGDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHR2</accession>
    <name>A0A1Q5UHR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_2383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHR2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHR2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="81"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="497" mass="54681" checksum="AB15ED9213FB5873" modified="2017-04-12" version="1">MAALPHGGRIVPIPILTGHEQHQQFLDSTTPPPAVLENNCSQSTLDQTPLLAQPVDSEAMRRKKTLDLSSLEMPCLKERGLFALPTEGDGNCLYYSLSDQLYGDFHHGDDIRHILANHMAKNKTYFMQFVVAHGGERRRPKRAAVSAYATRSVDGAVPSEEDKERRFTEMVSATRKNGEWGSSEHLQAFCQVYHVDINVYTMDGVQAFRDVNASDDEHRDVVHVAFHDFKHYSSVRVLDGTHNPLLAKSRALDQFSLQLKGVQSKEDIKALIISDSKEAVDNKQTPPLSSSFPDNFDNLNSVSDTDSSTDGLTTKTADLAVDVFPPWDIQSIQDGLGGRYDRDTIVDVLQKCRGDIDRAFAALLGETDGSSDKPSIPGPNFKPSVQASRESSPFSTGSKRSADDSDDSEDQPPTARRGRPKKRVVSNLTLGVGISFRDDHNEVVSLNLRMKADAEKAKTAEKAQATPVRDASLSETPEAATKQGLRRSGRLSKPRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHW7</accession>
    <name>A0A1Q5UHW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_2387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UHW7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UHW7"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="340" mass="37796" checksum="881054DF6F871B6C" modified="2017-04-12" version="1">MASKYANDQPEGFTNKIERVAIVGAGGSIGKHLTEALVKTGRHTVTAITRPNSTSKLPEGVKVIHVDYSGDDDTALVEALQGQQVLLITMAVTAPRGTINKLVYAAAKAGVPYVLPNWFGHDNTNDALCDDSMLSPSRDSIIAEFKAHGTISYIFLVCNFWYEFSLGGGPDRFGFDFKNRSFIQFDEKDVVFNTTTWPQCGQAIASLLSLNELPDDGQDKSPTLSQFANNSVYISSFRLSQRDMWESVKRVTGTVDADWTITHESAAQRWKESRVAVERGEFGSFPRMLYSRMFFPTADGDLQSRHELHNDLLRLPVEDLDEYTAIAIRMGENDEVVKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UHZ2</accession>
    <name>A0A1Q5UHZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_2440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000251">
        <property type="protein sequence ID" value="OKP12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UHZ2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="9">
        <location>
            <begin position="301"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1274"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1319"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="950"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1205"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKP12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1390" mass="152310" checksum="2DD243C44AEC1391" modified="2017-04-12" version="1">MLATQASDGDLRVWSVAKPPGKESPRVIRVLKRSDSTSSDPKWMAWSKNGRIVQYLDGETWSWDVRTKHVTYEPIPTIQGVRGIASYGPTATLFTLGPQDTVQQYDLESPAMVANVQHLAVASRSTASEGSRSRTMSPRRLQDPPDIREKGAGRRTPFDTNGVESAKQARADLISPASSRSRTESVSSKASSGKYKMDRPFSPPSRSAQSGTSFSMSGQDTPQPSASYAYASSISMSSAKSSRAGSRLRNEVHLSPAERNIVDLFPFTRARLNDVPYRQTPPLDETHLTPDDLRQQMLSVVFGWDGDIQDLLRDELSRHKEGSQSAILLTRWLNDNDSDQMAAMLGPGQVTIADWMILALSQMSGQTQANKVGQAFVQKLLEIGDIHTAASILLGIGDCNDAIEVYVSRNHFMEAILMTCLLMPTDWQRQSYLVRRWGEYVVSHSQQQLAIRCFMCTGAEPTEPWTSPAAQQAASFAEMIRGKSPLASPEPTQPLGPSLIPPPNRPKSGSAQRPAGKTPALKLITSFDHQPNQRYRFPGLKSDDRTPTNAPGVTPIAESAVPDSAMSPGGFGSYKLNNIQSLSQAMTSRTNTPAFNRRRLPSIGETPVDVHPPAFSRNHSYNTSNYGSTSENDDTSGHEHSQDERPSDGGLLTLSSARYNPSSESNSMKPSPQTAVQAPDHFASLKGLPSPAPGFIDALREHSDIRNGSRDRKPNGLQLDLVQAEEAPLDSQGLLPSGKSTTSTLNSYTSAKSPSVRSIDQYISSLDEANYHARKQNGRRTPGRGRRNTDDTSSQQGSRVHQSREVSQETRGRNERRYIQPAKRSPSSPVPMSPEELARYHTGDSEKPRESRKKGSSRARSGSKMRKDGSRSRQRSSSRHKANRFQDASSRGRSVDRTGSAARSPSSPLPMSLPAQGVLRADDAEDPLRLVSGDRRLRSRHRSASRRRVERGASSKRDESPETRHMPSYSVPEVRQAPEPEIPAQSGGHEQLSAKVFGQEDLFLNGNTYKPEPVSDDAQELVSPTTPFVSLAEKKRRELAAAELEARRLSLARNPSAPNIPFPGELYNARSPVDSPPQVSGSFFPRAPSRNKIPPSKNSPEYQSGSDSSSSRSGVPLGLPATPRAMRHPKYGANGHEVERPPSVPTIPTDYSNGILLSDARYSGYQNEAERIPRSMSVPVAEAQANNASVPSDIPMHPRFNPHLPRSRSSSRSRNMGHRRTSSGGYVSGTSPHVTISIEETIENAIQRRPSGVQVEMIPPPPPPPILPELQHLNTPPPPPPIPLSTDPTSPRESSATIDIAIDHVNMGRLLPRAMTAAPALSGPNTHQNASRRMSFEHRRNRSSNESFANKLRSLTRMRSNSRSVEPWGNTEAEWPYNDVPLSHGQSNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UKM9</accession>
    <name>A0A1Q5UKM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein CSF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_1122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5UKM9"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Csf1 N-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="3">
        <location>
            <begin position="2454"/>
            <end position="3197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3094"/>
            <end position="3119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="3101"/>
            <end position="3116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="3198" mass="358348" checksum="E990F5611308F07A" modified="2017-04-12" version="1">MASTSLTASYLTPDPSFNCALFFLFYFNRLFATLLSYAIRAYTWHYYRVYVDIKALQISLLGGRIFFKGIRYHGVNETIFVHGGFITWRYWKRTVERTDLSHAEHKSNGSNAPENDLSEAFPGDPSDERIGEQGGVKKTIELPCRISITAYGLEWFIYNRTPAYDSILAGFGYKDGNLREDDGSFLSPPEAQSEPRGTDSTSSIRPGDAAKSTSDNLSEHSMGEGQNLNPRKTEIRDSELSEPVSNLLQLLPVKLDCRKGAIVMGNENTRSVLTTTFDSAEGTIAACNAGPLDLYRQLFSFKFDHPVIQMRPNPDFKQSQITTAKILGAVKEETSSSERKRYPFSYKLQKRKIWHSVRELVPYFQTSVESFHASIRQNENMPRSQAEFPDVRWVGLSRYLDEENDDDHEQWNSVEYGRFSTILDSPRLHLVYFWDIPGRVGPDVPRLAHSDQHTNTNINQALPPEWGIDLKIDGGDINYGPWADRERVGLQNVFFPNFYRSSEPAEHLAPGVLRQSTVFRLRVEINKELTLRIPTREPSKDWIWKGRADAIRGASKAKKQAESRKRRPKEGEKGHIGPDIRPFGWLSLRVGPDSTVNYTMDMVASSVGFCNELSLDLRESKMSSSVNHGLLWQCPRHLVTCDLSNPLIWNNLRSWQFNVKSQDMELFLLRDHIFLLTDLVSDWASGPPSDYHTFVPFIYNIDLTFSNLQLFINVNDRNIISNPSDLEDNRFIVIKGRNLTSNVMIPLNKYQPEQNAVEFKVNLEDGGVDYLIPLWDTLHAFLPGKSMATLESLFIDGSYNYFSATSPELIDTLALNIDGVSPRLYLYGFLIKSFMAVRENYFGDEMHFKTLEEYQELAYADAQPSNPTGINPNRKSNDMDVLVHVTVDRPCALLPESIYDNSRCSRICAASLEVDLRFTNYYMDMQLSISPLKLDLQSPRPDGSSVISSTQLFIDGISAYGHRLFGLPPAEPTYVCNWDFDVGKVLGECSTEFLACLASGLESFDFSFDNEENALHPLFPPILFDVTFLRANIASIHISVLLDEIAVILDSQPLSIRFNDWANSKFSKRLSLTAPGITLAAVDRQSVPLSLRMTDKKISPLGLIEMAIGLKMALRRRDIAESRRLQQEHIKVQDQRTHRAQWLLFDWEEIAPTSSLPHGDDTISPPTMPIPSMPEPINGRHRSATASYRGFSGTHAAASSRSFLVHSERSSLRSLKSSPKNLSRSSSRSEPKGRPVPTPRDASWSTVQLSKAKDSPYSPTAIRDANPWIIPHFSYWKLSLDRTELPSSINGENTRDRDTDTGANSKSMFLTFEDDQTTYTNLAVNLPLGIRGFCTPKFIHSVALLMDGMEPKRPIQIIDSLQKDVISDIVGYDKAMSQPKKSTAIAVRVPTIQLRLVDVSGCPDQRQVEFRDEYTISVDNLRAEFQKRVERHKGDLLEGVKQGITIHAAADRFWVSVEGSRTDSFEEKARFNCSLGDMNFWLVSEPNIRSHLQMRHFNIVTSAKSVERLAFLVRRAITMFDSVASAFQHNSVSSKQRMRFLIHFLTKSAGDIPDPNFLTRMSNVLRIASSHLRQHDSWKIISRIRNIYQNLPVNRQRELDRKCQGDKFSLPPDAKSTVLRGFDQWRAWDLAHVDKSYVMRKIWSSPEPQAVNSEPFMSLSCTVKTLRVSLDPGPRESDFIVEDLSAVASLIPHKATQGGETKHKKVATLQLYSSSAALRLRWEVVDLVEGVIKVMSPMTLESSPKPSVPAPAEQKLTEIQIIFGTDFGSVTLDAINLKLALVSRALRGSVIHTSQGTKNTRNEALALLFSAEACSSELLSQSRTLMLSRIADPYLYLSLISDENELERKHEWKVAGSCRKLRYEMKEDPVSLAHTADRLIEDEIRYIRRLVDNVKLPKSQPHLATVSKKPTHNKINVAMFLEDYRLSFSLLPSLTYLISGEVARMSVLPTETSKIEVDFDNKKNLHIFTSGEGDRSRNLSTLEMPPANGRILANVFSERKEVEVDMTIELIRVEASSVRSLLGVLTGPDVSHLISDLKQNVNVLQSHLEDTLSLQSSKPEPEPVTQDSVILYKSRLTVAGFEIHALAPGLNSNKYSAEMIFSLGMMQMRLQNGLDRGYAMEYPEFSVDASQINFELCRRENSKSKPYGGISAAIKLQGTSTVRENGEVMRAYHLTSDKLDLELFAETAALVVDIAIYTQERIKTLDLSHEVERLRRLRHRNQHHNRPRTPLEAPEIHVNDNDPAQAFLNAFYSLEFRDIQAAWNMSTALSGGSSGRQPEDLVFSIKQVELSNKKKNAAKLRIENMQLQMVPFRADRRKRSLNSALMPELVFNVAYYSNGKELWLAFQAAGKSLDIRATSEFIIPANMIRNSIGSASEALREGKAAWATKPSPDNTDKDSNLFGNRRLRSILVDVDFAGATVSLQGKQSHDSQTLLTATLKGSRLSESKYGQYVQGDSATTATLRAPGVALKVQFEDNGTDDPVLNAELKVDPSTNVLYPTLVPLVKQMSATVKEIMGEQQQTQQGHPRRASAAAKLQPQKLMQETPFGAPDPNSILGRCKVNVGLLFCKQEFSLSCQPIARVAATAQFESVYVTVNTVQSTEQGRFLALSLAFNGLEASVKHVYSNESTASFEVRSMVLSLMNSKHLGRMSGMSAILRVSPMKVSLNAKQLQDSLLFREIWLPSDDDEPGAESPPPQPEQPEAQTYIVQRYQQVASTSAFPWNTTIAVEKLEIALDLGSTLGKAQFAIDNVWVSSNKTSDREQSMCINFDSVGIECKGRMAGIVELNSFKVRTSIKWPEETAGHTPLIQASIALQHLQAKVSFDYQPFLVAHVAEFDFLMYNVRDAPGKGGERLFSILEGDQVQVFCTSLTASQTLALFQAWQRLVQDKQSAYEASLREVERYLRRKSTALPGRIEARSKELAKKDEEPERAPGSLHTGVVVNIRHVNLGAFPSSFFDNQIFKVEAYDAQARFGVSLESNKIHSALGLTLGQLRVALSGISRPPSAHLDELSVEEIAQRAAASRGGTILKVPRLVAGMETWQVPGTRQIDYIFHSTFEGKVDVGWNYSRISFIRDMWETHSRALASRLGKPLPPSAVRITGGPGSGGGQGEGGGAGAEQQDKITAVVNVPQSKYTYTALEPPVIETPQLRDMGEATPPLEWIGLQRDKLPNVTHQIIIVTLLEIAKEVEDAYGTILGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL14</accession>
    <name>A0A1Q5UL14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL14"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="71" mass="7910" checksum="863D644A869623D7" modified="2017-04-12" version="1">MLSFLTVESPRWLLLDHEHDKSLAALVQLRGFPADADVVATEFNSMASHIEDRNAGLGNNSSLQIIRETFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL38</accession>
    <name>A0A1Q5UL38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_1284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL38"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="211" mass="23463" checksum="DAE6F6185731463A" modified="2017-04-12" version="1">MAVSPNGVQLSIWMAVFTFLTSVVIALRIWAIHLTRKSLQLHDYFVIAAHTSACAMVGLNYWAVANGLGGHTATLSKEELDIQFKMILGVSMTWLVGTVCCKLSILSLYTSLFRTFRPIRILVWVVSSLVVGYFITFLPLFLTQCHPVSYQWHPVPGGGCRSLSIQEIASITLNIFLDSTIALLPIPAIWKLRMSLRNKLTIAVMFGMGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UL44</accession>
    <name>A0A1Q5UL44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000157">
        <property type="protein sequence ID" value="OKP13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UL44"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UL44"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="403" mass="43190" checksum="CD823C55B1DCBA4E" modified="2017-04-12" version="1">MADMDEFAQTRGADDLFDDEIIPVSAEEQQAQTEVVGVPAEPEPTPRQEEPVVEKQPTPPVDTPHRGRGGDRGRGRGRGQGQGQSRGQGPAKGRGLQDSQWADKKAAEKPPRPPRHKGPKTPKEPATTKQPEPAAPAQPEAGPTEQAGQEDEVPGEETTGNGTEPQRVPAVRGDRSATGGIRKPKLTEEELSKRIAAAKENAAKKAAAHARAEADQASFLEREQIAAEKRRKEAANRKVMDNEREQNRQRKLNAQTGREWDSQKTEDDYNPRGGGSQFRRGMHGGVSGYTRRDFDGASDDGPADLLSPGRGRGRGGRGGRGRGSPHGPRGDQASSKEPLERGGAKTSTPSVNNEADFPSLPAGKKPAPTPTVETKAIAQPPSMEKLEATMSPLTGTWADQVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULA5</accession>
    <name>A0A1Q5ULA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULA5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="56" mass="6084" checksum="F5D7986FDE458E8A" modified="2017-04-12" version="1">MGSSKQQTLAEEKKESESAWAAGGSFKGIEWISGTQQKVQGKDNNAREFLLAGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULF9</accession>
    <name>A0A1Q5ULF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000136">
        <property type="protein sequence ID" value="OKP13289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULF9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULF9"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="341" mass="38157" checksum="557E1DD93DB143DF" modified="2017-04-12" version="1">MADEVRKLVAQYFQLVDPPQLDIPPGNVLLRPTVQETLYERMFDESLTPLPPAAYRTRVLKLVIARIEESITDPEVDELNDNLMDALGMLVAQPKANSLELAQKLSHVKYTAPLQSSSTKNREVTTIESRGLILSGGTTGKRTWEAALHLGSFLASSAGEALVRGKRVIELGAGTGFLSLFCAHHLGVQSVVSSDREPVLIENMRECVRFNHRGDGPFPFYPAFWDWGTPLEKTQELESFVDEDDLRFDVALGADLTYDTDIIPPLLSTVRDLFENYHVEEFIISVTLRSEKTFQTFLDGCESNSFNIELLPFESTPSEEQTGFFHSTSIPIKTYRILKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5ULT8</accession>
    <name>A0A1Q5ULT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5ULT8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5ULT8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45076" checksum="708155A37E3701B7" modified="2017-04-12" version="1">MNYLRPLSVTLFYYLSLPRTSLKQGLSTPRWILLTLTEWKFSKEGSLADEEKKVVPQVKETSNVLLVSNIVDWDRPDDPGNPINFRSFINFINVRIISTLTFITTLASSMFAPSIPELMEEFHSSSTLLAGFVVSVYVLGFAVGPLILTPASELLGRAIVYHICNIGFTVFAVACTTGGDTIADLIIQEKRGGVIAIHALGPVLGPVIGPVAGGYRTAAKGWRWVFWVLTMIGGFCTITSLLFLRETYPTVLLKRKMQRLIKETGRTDLRSKRDNGLSTQQLFIQAILRPSKILFLSPIVRKLNLGGDCVQIPVSDVFNLYLRLEDQYGFPTKSSGLTFLGIGVGSLLGLFVIGAVSDRILKANSKPTPESPSGTMKPEYRLPQLVVGTFFIPAGMLLYGWSAYYKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UM60</accession>
    <name>A0A1Q5UM60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">PENSUB_779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UM60"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UM60"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="482"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKP13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="596" mass="65968" checksum="50BF056F96ACCBC1" modified="2017-04-12" version="1">MFRSIPRRLPRQLPLATAPKRLVLRSFTCGYPRMSSPPAVHPPVSTTLPSDAYQLLSTADKAGPAEDALYEQQVRDVEAWWNSPRYEGIKRPYSAEDVVSKRGSLQQTYPSSLMARKLFNLLNERAAAGEPVHTMGAIDPVQMTQQAPNQEILYISGWACSSLLTTTNEVSPDFGDYPYNTVPNQVQRLFKAQQMHDRKQWDVRRKLTAEQRKDTPYVDYLRPIVADGDTGHGGLSAVLKLAKLFAENGAAAVHFEDQLHGGKKCGHLAGKVLVPMGEHINRLVAARFQWDLMGCENLVIARTDSESGKLISSAIDVRDHEFILGVAEDVEPLAETLQAMEREGASPAEIDAFELNWVKEHKLVTFDEAVDAHLAAEGASQSARDAYKSHVQKNPDLSISRRRALANDYAKSPVVWSCDSPRTREGYYHYRAGFPAATKRAKEFAPYADLLWVETGDPNVEKAGNLAAKVRAAYPGKKLVYNLSPSFNWMGQGFDEASLKSFIWDLAKHGFVLQLISLAGLHTNATITTELSRAFKDEGMLAYVRLVQSREKEMGVDVLTHQKWSGAPYIDGILGAIQSGSSSSKSMGEGNTEKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UMH9</accession>
    <name>A0A1Q5UMH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MNBE01000128">
        <property type="protein sequence ID" value="OKP13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UMH9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UMH9"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010005055" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="274"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="532"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="610" mass="66922" checksum="E65C9C82BBC3E1A4" modified="2017-04-12" version="1">MKATTASVLLALSAAVAARPTVDTEYDYTGPEVPVGDWIDPTVNGNGKGFHRLVEPPAVKPASSNPTNNVNVISLSYIPDGMHIHYQTPFGLGCAPEVKWGKSPRKLNKVATGFSHTYGRTPSCSQVKAVTQCSEFFHEVSLEKLHPGTTYYYQITAANGTTESEILSFKAAQKAGDDQEFSVAVLNDMGYTNAHGTHKYLVQAATEGTAFAWHGGDISYADDWYSGILPCEDSWPVCYNGTSTSLPGGGPIPDEYKQPLPKGEVPNQGSPQGGDMSVLYESNWDLWQQWMDDVTTKIPYMVLPGNHEAACAEFDGPGNVLTSYLNDNKANTTTAKAALTYYSCPPSQRNFTAYQHRFRMPGEETGGVGNFWYSFDYGLAHFVSIDGETDFANSPEWSFAEDIKGNETHPKESETFITDSGPFGAVEGSVKDTKSYEQYKWLKKDLESVNRKKTPWVIAMSHRPMYSSAYSSYQLHLRQAFEDLMLENGVDAYISGHIHWYERLFPLGVNGTIDTASIINNNTYYTNAGKSMTHLINGAAGNLESHSEFSSGQSQKNITAVLNNVDYGFSKLTVVNSTALKWEYIRGGDGKVGDSLTLLKPAGYKPGKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN31</accession>
    <name>A0A1Q5UN31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN31"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="88" mass="9887" checksum="4896F0F2F4C8954E" modified="2017-04-12" version="1">MDLWTETVEKIPQSLFKSQSSLYVNPIIPDLLLLSSTSHQALSFHHILYHSLLTTALGKIIPTMQPADDTGCTYYVVVKLDEVLLDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN38</accession>
    <name>A0A1Q5UN38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like motor protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_457</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000123">
        <property type="protein sequence ID" value="OKP13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN38"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN38"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000120">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="10"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="111"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKP13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="820" mass="91045" checksum="506086A94B73892F" modified="2017-04-12" version="1">MPSKQPQTSLFQVYLRLRPPMTQRPDDADRFLTVEPPEASQDDGEIVAPVPTHITLQPPNDLRKRAIEKFGFTKVFQEDATQLDVFHDTGMEPIIRGVLKEGRDGLVATLGVTGSGKSHTILGSKSQRGMTQMALDVIFRSLEPTKKTEDDSISPLTLASLAASDASEAQIFSAQTFLEAVYGEPSAGRNSRAQTPMSPSRAHTPQTVRTSNPPNSHEGSPTKRVPVPGPGLPTIPESLRSPDPSRIYSPNGVDQLSFDTLSTEKPRRIDPRSMTPLPFTRPNIHEDRLAKSRLYVFKEPTPALVFPRRQPRERPPPTPRLPDVSHLAVELNPSSDYVVLVSMYEVYNDRIFDLLSPSIVPGQGNNVSRGNIQKDRRRPLLFKPTEGSPDRKLVAGLRKIACSSYEEALAILDVGLTERKVTGTGANSVSSRSHGFFCLEVKKLAHSKRQGEATWTGNTLTVVDLAGSERARTAKTAGATLAEAGKINESLMYLGQCLQMQSNLQDGVKTALVPYRQCKLTELLFSNSFPSSNQMSRGQYPQKAVMVVTADPLGDFNATSQILRYSALAREVTVPRVPSLTESIVSAVSARGRSTSGRTSPNDASAIAEDLGRAMAEIARLSKDCHGLAVRLAEEEIARSEVELRLQAAEDRCVMIEQEVREECWADMDEQMEQERKRWQTAWDEQIGRNDDHIDKKIELVSRGFNIYEDPEQSMNDRVEDLENENEQLRRRLAILEREMNSHSPTRKPRAKHAPPSPNRTANRLGRESDIENALQRMNQLNLTDSMFSPPSPTPKSSSPGKKTRKISTRKWDLAPESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UN72</accession>
    <name>A0A1Q5UN72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000122">
        <property type="protein sequence ID" value="OKP13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UN72"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UN72"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF21">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKP13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="88143" checksum="CF96DD195FAC7721" modified="2017-04-12" version="1" fragment="single">LVMSFKIPGSALGRALRSGLVGQRVTATGAQLRLRLPAQRSYSNANGAPEEIPADNEAEPEPSFEDSEKPARFNRNGANRGRKLRGDKPVVDVEKRKQEERALMAIAAGSKSEDGEMNDEIRGASYSRKTISMELKWLEDPRDLADRVARILQSGDPGMAAALVRQAQKDGKRTDVAWNHLLSYCMQRGFPQVAWKFYNDMKKRGRMPTSVTYTLMLKGLADAPKSVANVRMAESIYKSIKTSEVEPSIIHTNAMLSVCDRHNDMESLWRIAGDLPEEGPQAPDMRTYTIILGALQYAARHDIDKMSPNDTDKIVERKDQMVMEGKRIWADVLYRWTKDQLQIDNHVVNAMASLLLEGARERDYYDVLALYHQTMGIPIFAKQPAETTKCSRFTMFRLAFLRRSQELVSQRTDDVPFVDENNQPLREEPDVEEEALEEEGEEEVENFDKIFDPVVPKTAELSYLQPGSKELTFIEDVCHRLPQGFAAGYSYWDHLTVESETRFDPDAVAYAQYLRLLRAGRASKRAIQVLQNQALPAGLANEKLFHLAMACCRRDRNNASVLLHANELLEIMHKALVLPDPRVLESYLELVQNLSQAPHVLLHLRGLPKEDRSKVNDLRVLGKRLQADLHTAAINALRPQVHQLHEALQEGKPGRSSRWGALKNGSGDISGALAVKVMARVRTVIDETLKSEYTPFVAKDVRKILQSESKLLRTYSDKETLKKFSNFSVHPTVEQRNAFRERQLEIVDEEVLERKGQKADNSDEVEVSSSSESAKKETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UNE7</accession>
    <name>A0A1Q5UNE7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_269</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="MNBE01000120">
        <property type="protein sequence ID" value="OKP14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UNE7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UNE7"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKP14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="321" mass="35126" checksum="794F1BF313C73C3B" modified="2017-04-12" version="1">MSSSNSIKLLTGNSHPELSQLVADRLGIEMTKIMVLQYSNQETSVTIGESVRDEDVFILQSTRPNDINDGLMELLIMINACKTASARRITAVIPNFPYARQDKKDKSRAPITAKLMANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSMLKWIRENLDVSNCVIVSPDAGGAKRATAIADRLDLQFALIHKERARPNEVSRMVLVGNVKDKIAIIVDDMADTCGTLVKAADTVMQHGAKEVNAIVVHGILSGKAIENLNGSRLNRLVVTNTVPHAEKKELCDKIETIDISPTLAEACRRTHNGESVSFLFSHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPE8</accession>
    <name>A0A1Q5UPE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family 16C member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_14115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPE8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKP14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="286" mass="31437" checksum="067BB545F076D299" modified="2017-04-12" version="1">MTFDLQALISEYSSWPPATAWKVVPPFTLLWAAYHINQYLNTRALNNGVQATFDWKKEIVLVTGGSDGIGAATVLKLAERGTAVIVLDIRPLKFDAPKNVHYYRCDLTNQSELKSVAETLRRTFAVNNLGLVWAAQTFLPDMVAQNHGHFLIMASQTAHLATAGVVDYAATKSAALAIYEGLQTELRHIYRAPAVRVSCVAPSAVQTKMFRGIQTPASVTLLKPSDVGSLVAEILWSGRAQNRMTPALAYISPPTRALPDWMRVAFQDLGKDVMSTLSPHQPMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UPF6</accession>
    <name>A0A1Q5UPF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_14141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000099">
        <property type="protein sequence ID" value="OKP14362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UPF6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UPF6"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
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            <begin position="298"/>
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        </location>
    </feature>
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            <begin position="316"/>
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            <begin position="359"/>
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    </feature>
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            <begin position="482"/>
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    </feature>
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        <location>
            <begin position="515"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="830" mass="90312" checksum="E9DCEFD2CAB2091E" modified="2017-04-12" version="1">MPSLTLTDPDMILPYDGSERESQTPSPPSQLVYLTNLNARYNTADPQAGSGRPKKNFSRHRAHDDMNASRRLSDIGEEMSPARSEKFDDVDVEASRHQRQHQFQQRQGSTGSPLPRNQLAVPGKQDSGNAAWSSSSSSTVSARSGRTSAGASSPQTAPESSPNSNAVDGGSKSGSGDGVKVGKGVPDSSIVASAAKGKGPGEEFSSAILSSEAERILENAKKRLTLMEGNLNRARSSVRLTPSPSPSAPGSTSPMGLHPGGLYRSISKTDRKGSALRRQSFISAQDSSNNRHSRVHSETNFPAESSLSSDTKRVSRSVSAMGSSSSNFHNDDRSFQYEPTRSYLTHRASISSIRPPHLQNMQSPQPGQSPVSVGSPVLQSPVIREDSSSCSSPRGLGISEEDESKSNGGDFSPVYSSYGPPSRAQSQLQVRDLQYQMKGLHIKISSLKVRTQEDNLRRRSLQSLRTPSPLTAADPWYQNGLEVRDGRSSRGSNPRRDGSAEYARETQSRQYTETNSKDRNGHYNPERADDSPVEQSPNLSHDTSESWQGHEHNEYDGRQSAAETMYEDAEEGDYYYDGDIDREALDEILREPLDADLATPHEEREDAFDYEHFILHSALGNFSQQMRRVSVSSHGSVETTRPTQSVRHSRTNSSLSASTDATFATATEGESMPEDEDDILYWDRKFNHELRHRHHSHQANAVAEDRSATPRVPREDGNATPVGVLQSPARSIDLNSRSTAGSATPTSLVSSLVSTVRAASSPHPGSATPTSGGINDDDTQMLEQLFASLGQVCTDLQAITTSPDPDLKAARVLRRRLDAARRVLDGELDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQ13</accession>
    <name>A0A1Q5UQ13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_13919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000079">
        <property type="protein sequence ID" value="OKP14567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQ13"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQ13"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP14567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="64287" checksum="551088DD4FC315AA" modified="2017-04-12" version="1">MRPLESDLPWDASKLTTRNDLSNVCSVCRSFDVIATPFLYRSLIFRGSPIDGSHWSKLPDDEEVKTQDEAEKLSFGLLCRLLDNRNDLLRSFVREMTFEEGNPDRVWRMLQPPNDVLATLVNRLPNLETIHYHDDLPITDGFVKVLLGHKKAPKLHLLGEYGRTRVNTKMPFVQKLHTSVDAKARAPRDLSEAEKRTRARPWEPQELALHDLFNAFPNLEELSVSVNWLQGGCVMGGRPSPTRISELDLPEGAKFPPLTSLSLSGYSVEGDEAALWRDSFPWERLRSLSLGVQSTPGLLELATGKVVNLKEFQITSYDPLSSSAGLDGFLRSIDSLESLTAKGAVPSLNSVLHQSSLKHVCLHEIEEPDRERQTLDAEQIGNLSRHCPKLTSLEIDLDPNGTWPDDIVRALATGFKNLHRLSIHIGLGIAHAEENPSMEEDFPQVLTESKAQDFGKRFFELRGPSVLETITLKTGENLRWFRQWQPMYARAEGNCAKVFEIYAPIEGNDEPRLKELESDDDRWFREFQERNMAHWNSTRQFNADSKPQRLSRSPRVFKDQAFPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQB0</accession>
    <name>A0A1Q5UQB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQB0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQB0"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="315"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="448" mass="48261" checksum="8880B18F380BC913" modified="2017-04-12" version="1">MDPYDSDSSVDEDFTETSVLLGYADEEVIEDTISHLGGWPSWIDENTPPPGEFANCKVCNSPMLLLLELHGDLPDHFPNNERRLYIFGCPRKPCNRKPGSIRAYRATRKVSLPGLPLPQPQKKEEKPKPKPESKPVEPVAPLKPKVDLGASLFGATALTSSVSANSNPFSNPFSATPGSSAAGANPFAMPKPATPTVPAKAKAPAAKPPTTTISTSALAETFADKVRISSPAPASASGTATKQTPESTGVQTPWPAQSAFPAPYKKYFLDAEYETMSRPSTPTIPENVTVEPVEEDSAGGEGNVELKDTFESEMDKAFMKFSMRLAHNPEQVLRYEYRGAPLLSSYTDLVGKRLHPEHSAGRVTTVGGGSMPPCEYCGAPRVFEVQLVPHAISMLEDGREGVGLGEGDAGMEWGTIIFGVCGQDCAPEKIGQLGWREEWAGVQWEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQB6</accession>
    <name>A0A1Q5UQB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_11428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQB6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQB6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012772981" evidence="2">
        <location>
            <begin position="19"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKP14670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="918" mass="96164" checksum="BE8C739E4866174F" modified="2017-04-12" version="1">MLHHLVLLLLAAIWPAFAFPRAALNRRVRTPEIHARETESNDNIPKMEGFNITLSPKKWQPILVKSFDRQATSTLTTTLTISDHATAFTIKPSHTAVEAATFTTTSSGHALIYMCYPTLATAAGTTKTKCIKDTKTTLGVIDIGSVTVTPNPTGFFVGSQTLTPEGVVTVGTHTLSLGPSGGLIIDGSSTHIDSPTTTTHHGGGSSTPITTPTSKHTLTSKPRTSTHKTSTRTSTKLTSTHPTTGTTKTSTRPRNTSTKHTKTSTKHTTSSTKPNTPSTKPTPKPSHTDEILTIGSLTVTADPTGFQIGSTTLTPGGMITVGTQTVSLETGGGDVIIGGTTVPLTATTGTSSTQSWTTLSDESTTGLYGIVTLPGFETLTTPTIITTQYIESKTKTTTGPIYVGTGGIVLQSWPPSTDNDHNGGGGIIIPDPIRPSISSPKLKCPAILKWLCGSDHTSTTDNGSDVDPDDKPNSNPKDDPNKDDNPTTDPTSTHTSKTSQKPTTTTSTCTKTQTVTDCNIKCSPTVMSGKSTTTTTCFTTSCSTVEGCSKTGTTSTTIITSQPCGTGTASACPTFTDGTGWVYPDITIDTAAVNKLASSIMSDDDSILAAFSSAFSQTGVSTTPTTLATTSKTRSSAITRTTSHTASSTIMTTKTTKTSTKTGSSTATTTSALSCVHQYDSQSDQDNCYCEGHTGLYKTMSSTSGMTNYQPCAWTTLPPLYTDVNVGPITSTLSDGDVVYCTSAHWAENGGSSKYCLGSVSTISTASHKTTTTISSSTTSTGVSATGTGSPTGEMYIGIVTEGYTFTWNVYIPTVGTVPNWCDDSMGSMSASGDTTRYYYPPDIKFQDLDGKAKEYPCVYTGDKDTVGKLACEGMGEVPCTGDFPQSDDSPLCTNSVVYAGSAFPRVYCRWYGSDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQH4</accession>
    <name>A0A1Q5UQH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_11480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000071">
        <property type="protein sequence ID" value="OKP14722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQH4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="121" mass="13320" checksum="C0D094DD78FA4568" modified="2017-04-12" version="1">MSAGALASRRIIEQSSYTTTPSRSPGDVTPACGESIYKCDLGEENIKKVDSTLEAERTIDEKKTKSRSDKTSFRGESPKNEPPTRQILTKIRPSKPLDRAIAKFPEGEHVSREIKSSLGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5UQN9</accession>
    <name>A0A1Q5UQN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_5861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000058">
        <property type="protein sequence ID" value="OKP14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5UQN9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5UQN9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF19">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G01480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="56"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="545" mass="60373" checksum="C5F0A3AEB9619742" modified="2017-04-12" version="1">MAQMIVFRNGRIFSPKKDAPTENEFSGSFVVSGEIITHVGYEVDEAVRTAKEEGAEVIDLQGRVVLPGFIDGHTHFLLFGLARQKLDLSDCKTFEDIENSLRTYAKAHPELPRLLCRGWHQPSTNRKALASMIDHIDSRPIFIEALDLHSTWCNTAALNELGVKAIPDPMGGKIHRDENGQPSGLLDETAQTGIVWPHLMNVCTMEERLYALDDALRVYLESGYTGLVDMAMDNGAWEALRLLRARQDVPIHIAAHWYIPFTDDDEELSRHIEEAIAKHQEFHPSDSPDFCVVGIKIISDGVVDGCTAALSHPYIQTDGATCVNPIWSVDGMRKVVKKAVDAGLQVAIHAVGDVAIKQAIDSIAATNIPSRRHRIEHLELASVEDGKRLGQLGITASVQPVHSDPALTKDYPRILQPHLWERAFPYREYLEGNACLAFGTDAPTARHLPLPNLYNATVRKSALEPQSDQMTNPDGAITLLQAVAAATYGAAFSRFAEGWVGSIAADHRADFIVLETEWTPETLLNTKIYQTWVRGRKVFECQPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URS3</accession>
    <name>A0A1Q5URS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_1804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000020">
        <property type="protein sequence ID" value="OKP15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URS3"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKP15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="117" mass="13384" checksum="5C2B67BD94006728" modified="2017-04-12" version="1">MIQTPAPSASLTTEFDYVLRHHNSLAAPVVGLLDLYLCLWKCYVVDSALKIRLEEEQRHLQRSIEWLNAECDVLRQCCNDQALELFGRRQAVAALNDGIVEVLKASEKRAYRVIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URX5</accession>
    <name>A0A1Q5URX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_1431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URX5"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKP15217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="137" mass="14868" checksum="24E28ED11E9B87E9" modified="2017-04-12" version="1">MNRITRGAEEMKALYPSLVTVLSRTSSSADLPSGSPDGGDLALAVALPILGWDCELKNLQRAQGHTTFSSRYEEIDFKVVVGQMLLVNAMINESTIDKAILSRSPVARTDHLVAVSGYVWFLDVTGVVVYGYLGFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5URX9</accession>
    <name>A0A1Q5URX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_1438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000017">
        <property type="protein sequence ID" value="OKP15224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5URX9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5URX9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKP15224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="474" mass="51528" checksum="8BFE3BA4ECE6C44F" modified="2017-04-12" version="1">MADSTVSSATERTPIKSAVYGAKPAEAENGPRPADGITGLYEGNIFEASPENRRQLGVFSATLLIFNRVIGTGIFATPGTILSLSGSVGLSLFMWVIGTFIAMAGTAVYMEWGTAIPKNGGEKNYLEYVYKKPKFLATAMFAAYAFLLGWAASNSVVFGQYILNAAEIEVDRWNQRGIGLACLTAAFLVHSIALKWGIRLQNLLGIIKLIIILFIVVSGWVALAGHTKAETPHNFRNAFEGTKGSGYSIVMALYNVIWSFIGYSNANYALSETKNPVRTLKIAAPLAIGTVGILYMFVNIAYFAAVSKEEMLESGTVVAAVFFGNMFGKQAEKVMSVFVALSAFGNVLSVLFSQGRGGLIYIYLNRSTKYPNWNPGIRATLPVTVFFLLSNVYLVIAPYVPPDAGQNVYEQLPYYLHCVVALGLFAFGALYYVVWAVLLPRWGGYVLVKESVVDADGWSRSVFTRLPLTPAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SNP9</accession>
    <name>A0A1Q5SNP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">PENSUB_13656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000773">
        <property type="protein sequence ID" value="OKO89590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SNP9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SNP9"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012750368" description="Protein ROT1" evidence="11">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO89590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="226" mass="25441" checksum="3755CE96B24A669B" modified="2017-04-12" version="1">MLWIWTLLATTVAAASVDELVGTWTTKSRNVLTGPGFYDPLKDQLLEPNLTGISYSFSADGYYEEALYRALANPADPSCPSGMMQWQHGSYVLLANGSLILTPIAVDGRQLLSEPCRKGISSYTRYNNTEYFRGYSVQVDKYHGIQRLDLTQADGKIMQPMYLTYRPPKMLPTSTLNPMPRGSRKKRDMSGSAFHLVIKEELINPDRWWWFGVLMTSLGGVAFFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPI7</accession>
    <name>A0A1Q5SPI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_13560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000766">
        <property type="protein sequence ID" value="OKO89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPI7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPI7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="171" mass="19869" checksum="C48907107550CAF7" modified="2017-04-12" version="1" fragment="single">MLDEVNSLNQNKTWELVDPPKDRRILSGKWVFKLKRGPHGEVIRHKSRWVVRGFTQEEGIDYDETFASVVKPMSYKALFAIGAALGLEIEQMDVKTAFLYRDIDHEIYVEQPHHITDGTSRVCKLRKALYGLKQAPRIWYQTLTNFLRNLSFELINADLGIFVRSNIYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SPL7</accession>
    <name>A0A1Q5SPL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH-dependent 1-acyldihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">PENSUB_13549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000764">
        <property type="protein sequence ID" value="OKO89967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SPL7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SPL7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OKO89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="329" mass="34848" checksum="F545098835593F9A" modified="2017-04-12" version="1">MSDSKQRSILITGCSQGGAGNALALQFASKGFRVFATARSLKTLANLQGKNIETLTLDVTDASSIKALAAEISTRTGGSLDILFNNAGTRGLSPEYSIAGFRTEINAARTLVYEAPAIEADPTRVRALFNTNVFGLMEVTTAFTPLLLASVSSGFSPIIVNVASVLARVPNPFASAYNASKAAVAAYSDTLRLELQPLGLKVKTLYMGEVSTPLMAADNINFGPESIYNVVEDSVKARTNTHLAKTMAPAQFAREVADEVLSGKSATIWKGTNAFVVWFLNAVGPRNVFDSTVLKGVGLDKEEARSSIFKLGQAKDKKDAPGKGQSSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQQ1</accession>
    <name>A0A1Q5SQQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Secreted glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_13461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQQ1"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010264938" description="Secreted glycosidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="291"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO90328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="87194" checksum="0BC74AFEF1BDF408" modified="2017-04-12" version="1">MLPSKTHPTGILITALYGSISLAAAVGSTDSFDVLDYVDPLIGTANGGHVFPGATLPFGMAKAVADTVGENQAGFAYDTTVVTGFSHMHDSGTGGSPSLGNFPIFAQPSCPNDDINQCKWQLNDRAVVWKRDSAKARPGYFSISLANGVQAEMTTTNRSALYRFTFDGASSESLSPVVLVDLIDLPQSRTNGFADVDSSNGRLTGNGTFNPSFGIGSYDLHFCVDFKGAELRDTGVWTKNRANTTRKTVSLRADGTNSPDTLSAGTFARFHAPKDNTILARVGVSFMNVKQACANAEREQPNFDFDGTRSAAEDAWRKKLSVVSVDADGVSKDLQTVFWSGAYRSLISPQDYTGENPLWESDEPYYDSYYCIWDSYRSIHPLLTLVDPLSQSLMMRSLLDIYRHEGYLPDCRMSLCKGYTQGGSNADVLMADAYLKKVDGIDWDTAYEAVVKDAEVEPANWNVEGRGGLQSWKSLGYIPTDDYDPYGVGTHTRSISRTVEYAYNDFCIAEMAKGMGKQADYEKYTTRSGNWAHMFKEDQKSSINGADTNFTGFLQPRYTNGTWGYQDPIFCSPLLNFTSCYLNPSGHETYEGSSWLYTFYAPHDMGALIKTLGGAEQFTSRLEFLHESGLLYVGDEQAFLTVFQFHYSGRPALSAKYSHFYIPSQFNTTTAGIAGNDDSGAMGSFVMLSMMGLWPVPGQDVYLITPPYFKEVSIKNAVTGKTATIRNVNFDANYKSIFIQSAKLNGEAWSKNWLTHDFFTQGGVLELELGLTESKWGTQTEDLPPSLSNYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SQU6</accession>
    <name>A0A1Q5SQU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_13514</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000758">
        <property type="protein sequence ID" value="OKO90381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SQU6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SQU6"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="13">
        <location>
            <begin position="512"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="727"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="728"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO90381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="839" mass="89296" checksum="00C469AAF39D62CE" modified="2017-04-12" version="1">MGFDDVSSGPDSSKIMESDGDKKVYAAAPPPFEKDIVGEMSEAERHIYDHGIKKFSRLGWKRLTVVLIVEAIALGSLSIPSTFAALGMVAGVISCVGLGLVAIYTSYIVGQVKLAYPEVANYADAGRLMWGRFGYELINLMLALQLIFLTGSHCLTGTIAFQNITESGICSVIFGVVSAIILLLLAIPPSFTEVAILGYVDFASIVFAIGITIIGTGVQATNAPGGLAAVDWSAWPKPGLTFTEAFIAISNIIFAYSFAMCQFSFMDEMHTPSDFPKSIWTLGITEIIIYTVTGATIYAFVGQDVQSPALLSAGSTLSRVAFGVALPVIFISGSINTVVFGRLVHGRIFANSPIRFINTKMGWITWLGVIAAATIIAFIIAEVIPFFSDLLSISSALFISGFSFYFPSLMWFLLIRKGSWTEPQNLILAIINAFIGLIGLIILVAGTYSSIDDIGVCGTGAYYCAAPSCLFQYGPACDANQTPAGINTTSVPRPKLGSTPYGVSIRDCSIPGKVALTFDDGPYIYTSALLDILKSKGVKATFFLVGNNGGKGQINDPKTGYPALIQRMYSEGHQIGSHTWSHADLSTLNRQQRYDQVVKNEIALTDILGFFPTYLRPPYESCNADCLNDLRDLGYHVANYDIDTLDWQGDYGHSQGIFSSGLKAASAGHGFISLAHDIHDKTVHTFASYMIDTLHAAGFTTALYGECMNDPPENWYRNSITGQPYNGSLSHNSSSASTAKSVSASSNSTTTNTIHTLSTSTSSPTPSAVDGGEGAFGSRTGNATSGGASGTNSTNVTNSTIAKSQSASGGATKLSTTAGKLGELGLTWGLLSWMFLTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SRE8</accession>
    <name>A0A1Q5SRE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_13291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000757">
        <property type="protein sequence ID" value="OKO90574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SRE8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SRE8"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF103">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="760"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO90574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110458" checksum="A844A31C2F78A911" modified="2017-04-12" version="1">MADTLRLPTARCPPLRQARGTKLNTIMEDTRESQFSPKGAGSPPFSRPNLPSPKLTLKTSGLSVPTHARLARLMSPLSAGTTSSCSDHEWQQQMQGFDDLYDASDDDNSTEISDSCFSAPGTQRSSLVTPITRNSVTSTGSRGSRKSRGGLTLDIPSSTDWPSLRGTCKSSPIPPTPPSRLPVSPVALSMLGRAVPASYAPPSLDGSISSDQESNLSALATPDTHSLPDTNWDAPDVHVRPDLDGSDAEDLGNDESRVDLQAVSFTIESPQSDWRNVLGRFPTLPTALQNTSTSSLGYEAEVPYDDPSRGSTPSDEGLYLPDGALAMLQHIPLDRTPETWSETSGDDEMWQLQPAPQSRPRSADGVTPASDLSGYSFSELSIPSPGGFFASLAPRARHTWSIPNDNLPPTSAVAEGFYNLPFLRDQGEVVEQVIEWPDRVQEDDPDTAIRDEDGPPTAIRLPCDTPTRPLTRQGTHSPVSATFEAVQEITQPGNVYEYDELYDNELQVRAAASLDRTSVWLTAQATYLSALNETNPINEIDSKANSNVGDKSPDQEEDIDAAPKKAVRFAEGVPESLSPRPPVFASRDSIYWRGFQSIRQRSNTADGFLHRNMRFDAIQSFRLGLMDMHLNSLMGKYELVLPERPAYKGPFSQAPRNSIITSVLAEKAQFSKLEKEQLVLAQLCQPMWAMDALRCLNGGKLLTSPVEKRATRTRKTPQSQDGQKPRAVRILDLGGHASCEWGWHAAQEFPHAKVYSVVNQTQAVNSAIKGPPNHRVVSVERLWELPFGNNKFDVITTRSLHALLKTECPSGLNQDEYDLVLKECRRCLKPGGYLEFMVLDAEISRAGPYGSASSVEFAYNLRTRGYDPVASKSFLARLRQGGYVNIKRAWMFLPMGIEPIEPLPPRETPAPRVPSQIEEYEAVQGPIGSTADIASITGILGGWMWEQWLVRLRAEMGHDRSKLLDGVGALFDEGRKNGAGWTCLSGWAMKPKPVKQMVQHRRTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SUL6</accession>
    <name>A0A1Q5SUL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="8" type="ORF">PENSUB_13003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="MNBE01000746">
        <property type="protein sequence ID" value="OKO91596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SUL6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SUL6"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF2">
        <property type="entry name" value="KYNURENINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="7">
        <location>
            <begin position="178"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OKO91596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="469" mass="51844" checksum="B24ADE96C8EA48DD" modified="2017-04-12" version="1">MTNANGLNGVKAPKPTFPAEAATREYAASLDKADPLRALRDEFIIPSKANVNTKKLAKPGLSSESSIYFCGNSLGIQPKATAKYMEAQLDTWASIGVSGHFTKMEDSPLSQWQLLSEQASGSMCKIVGASPEEVAAMGTLTMNLHLLLASFYKPTETKTRILMDWKAFPSDHYAIESHIAWHGLDAKENMVLIGPDEGTYEISTEKILSYIDQHVDDAAVLLLPGVQYYTGQLFDIPTITKYAQDRGLVVGWDLAHAYGNVDLKLHDWNVDFAAWCTYKYGNAGPGAMGGLFVHERHGKVDYSEGEDSPKFRHRLTGWYGGDRSVRFKMDNKFKPIPGANGFVISNPSVIDLTTLCASLSVFDKTSMTDLRQKSFKLTAYLEYLLLKDSTDADRQFSIITPSDPHARGAQLSLLLKPGLLHKVAQKLQDAGIICDKREPDVVRVAPVPLYNTFEEVFTFVEVFKSALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SW33</accession>
    <name>A0A1Q5SW33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SW33"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SW33"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="331" mass="36530" checksum="8150DB97C638B3DB" modified="2017-04-12" version="1">MPRRLRSDRESPPTVEVEIDHASQGSNQLDQPVRFITTATPTPAHSPLILRTPSRLPGITSDDLRILRTKQRRLQRSASLTTQATRELGPWALQGLASTLIFAQHEAGTAVCIDARGWMLTCAHCFGETAQEWRAHRRKWLLCYTGLAVQVECRVWDARRDLALAKVVCIEAPEELSSSHPVTSVFAFVTLSTSQSTTAPIICIGQPGADDLESAAPRKTAYDLIEISKGRLCGMIPDIDPQDNSEIGTLKHDAWTYWGHSGAPLLRRVDGSLLGLHSSWDDSTAMRHGVPLAAIKAFLREHLPKDEVNLAEPARSLEKKEPEIIVIDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SWB8</accession>
    <name>A0A1Q5SWB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_12883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="MNBE01000742">
        <property type="protein sequence ID" value="OKO92321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SWB8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SWB8"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010214090" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO92321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="326" mass="35748" checksum="752F13230DB10CBA" modified="2017-04-12" version="1">MRSPLAKIVLRSSVALLLASVGTVVASCSLPSTYSWTSTGPLAQPKSDWVSLKDFTNVVYNGQHLVYASVADTSGAYHSMNFGLFSDWSQMQWASQNQMINSAVAPTLFYFAPKSTWVLVYQWGSTTFSYRTSSDPSDPNGWSSENPLFTGSIFNGAALDQAVIGDSENMYLFFADDNGKIYRASMPIGNFPGSFGSAYEVVLSDSPENLFEAVQVYTVSGQNKYLMIVEARGENGRYFRSFTADNLGGSWNVQAGTESQPFAGKANSGATWTNDISHGDLVRNNPDQTMSIDPCNLQFLYQGRDPNVKPTYDLLPYRPGLLTLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SX82</accession>
    <name>A0A1Q5SX82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">PENSUB_12579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SX82"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SX82"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="199"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OKO92594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="754" mass="83109" checksum="8069290DF98C96A8" modified="2017-04-12" version="1">MTSYFPAGASTGSSPASSPISPPLSQRSTALSNRLSSVLSASYADSDIRDALETLSVRGIHNTPETRRQLRLDVQKEVVDSNAEIVKDFGNVAEQLKRIGSVISALNQTCDEMRKHIDQAKQETAPVLEEATALMDQKKGTETKQRLLDAFSKHFLVPEEDLMVLTAAEEPIDDRFFDILARVKQVHHDCELLLGGENQRLGLEVMELSSRYLNTAYQKLYRWIQKEFQSLNLEDPRISSSIRRALRVLAEKPSLFHSCLDFFAEARDYVLSDSFHYALTDAISGATGAGAGGDRSVKPIEFSAHDPLRYVGDMLAWVHSTTVSEREALEALFVADGEELARGIQAGLSSEPWSRIDEDEEVTFDGRKALSDLVNRDLTGVSRSLRQRVELVIQGHDDPVTCYKVVNLLSFYRTTFAKLVGPQSNLVDLMQALEKFTFGHFETLMRDQAGALSTDHAALAPPDDLSPPEFLLDALESLLSLMKSHEASVGSDEPAETDSENPFTPVLRAAFDPFLTLARSSSDELKETTAQTIYRTNIILAARATVQPFSFASATHIAPLSTALSTLRTNLLDVQHQFLLETSGLQTLLEALEPFSRTVNDETETQDEQSDKPDQQKPQLADLASLAAFQPESLVASSQQLDDFLPSALMDATDNLKRVQSASLVQSVTEDAVEAFCRDFEFVEGMIIAADEARGMTQVTFGTGGSVISGRSGRSSRRPGAGEDRDEGEDDKEDQWSLRSLFPRTTGEIRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXA2</accession>
    <name>A0A1Q5SXA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1316194.A0A1Q5SXA2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1092"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1227"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO92648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1368" mass="143508" checksum="1623E74A861FE136" modified="2017-04-12" version="1">MAGKGKKKKNKNNNNNRLPVGATNSNPETTDLPDEPALESAAVGCEDELPKIPQYQTFDRNTLEFSYYPVGSKANGLTGGKVQDNKKPSATEPAKEPAPAAEAKTEEPTSSPDESPATPEPAESSEAITPPADEQPAEAANASGEDAKVETEDAAGTDEAAPSAEGEAAPDAAASEPPAEGAEPEKVDESAALAETDSAAKPSDENGGNDEDFPDVDPEAGHDGVESEKEEAAKQAAEDAEEALSQADDEKTDAPADDPPAGDALAEPAPAGEAAPEAASDESKAEEPASQEHTPTAAEEAPAAAEETPAEPTDKAEDSGDSPAQAEEPAATEAPPAPEAESEAEKAAPAETPEPEAKADEEPPAESSTPGEPVEEPAAFTSKAAKKNAKKKEKKNAKKGKASKGTDTEPEPEPEPASELTPEPAAEPEPEPEADKPASDDPPSVEEPAEPAPELAAELDEKPADAEVKPEDAAVESTETTVPAEPESTEPAVEPETTPTEEPAAPEASQDDTLDATAADPPTEPAKEETAEKPAATEPEAEAKSEPEPETEPEPTAEAPAEAPAEAPAEAPTEAPKEESPPDDAAAEPPVKESAPEPASEEAPVTEAPASEPADQPADGAAPAEAVETPASEAADEPVAEKQPEEAPVETVLEEESPAVEETPAAQEESVAEEAPAAKEPPAAAEEPATKESVVEETPAAEEAPAAVEEPAESAKAEESPEEPPTADEAVVEQPVAEEPASEPQEEPAAEAAPTEESTKELAVEEPPADDPTPEDPPKEDPLPEETATEASPAEEPISEAPTEEVVAEQPAPEEPAADIPESLAEEPSAPQPESAPAEAVSEAPVEEHVEPAADEPEAAAAPTEASQEEVIPEPAPVEEAPAEPAPVEEAPVVEPAAPEEVVPEAIEAPKEEPAPEEPAPAEPEPTLEQPAPEESAPAEPAPEEPASTEPPAAVVEAPAEPIPPETPAEEPVEQPAAEAEQSKEMPVEETPAEPDSAPELAPAEPVAEPPVEEPPEEPREAPAEPAAPADEVAAEDDAPAEVVPEEAEDVPFAEASELPVGDSAARHNSRRRKKRPVNERERRNSKTSSEGQKKEQLKRQKSERGLFTNRWAKALEEARKLHEEKKRAEANNQRKQQAIAEDKERSDGSPSEGSVKSRSSSSKEKVEIPIEKEPPVVTVEAEPKSKPKRRSSEAEQSKSVKTSSSSKQASTSAPKPRAFLRYMSNAPPTNTNGLIVRPNGTSKSATDAPEKPRRSSTSHSHSSGNQERSSKEEKRPSGRTEKTHSRREDDPARQERRSRRRSSVEAEVSKPREREKKPEGSRRTHQSSKDKDGKDKEVRAHRRHKREESPPREQSKLKGFFRAIAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SXL8</accession>
    <name>A0A1Q5SXL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_12675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000740">
        <property type="protein sequence ID" value="OKO92690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SXL8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SXL8"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO92690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14370" checksum="2341B1DFEAD6E820" modified="2017-04-12" version="1">MQLLLSHGAEVNPKDESLIITAIDSRNYNAIKTREDQIEGDKGEDHFTSATQLYQRFINAGRDREAGDNDGNTPIFYYASAPKPSILREHWDHPRPSNPEDYKKMFSEHDVHKINHKGDSLLHAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZ20</accession>
    <name>A0A1Q5SZ20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heavy metal tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_12265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZ20"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZ20"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010326642" evidence="5">
        <location>
            <begin position="29"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="118"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO93202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="300" mass="33671" checksum="CF63860966C73F25" modified="2017-04-12" version="1">MKIVSNGVRIVTLAALILLYASKSGLLASEIQSSHDPFNGATETTRLLESSPGDNHINSPILEPVHGRSLPTASQPQDPRIHCTTIPSRNGWKYVMGYSIFLPYLWPSKSHELKIVTLVCLFLLVVQRINNVMIPIQIGVITTALASQQEAHTLSVVWPRILLYVFCRWLQTGLSSLRSALWIPVSQYSRMELSTSAFEHVHNLGLDFHLNKETGEVLSALNKGKSVTGLLEQVVFEFFPTLFDLFIAIGYFLIAFDAYYALVVGISSFSYIYVTIRMSLWRAQTRREMANASRHEDAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5SZE6</accession>
    <name>A0A1Q5SZE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein DML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein dml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">PENSUB_12329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000725">
        <property type="protein sequence ID" value="OKO93266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5SZE6"/>
    <dbReference type="STRING" id="1316194.A0A1Q5SZE6"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06060">
        <property type="entry name" value="misato"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="9">
        <location>
            <begin position="119"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OKO93266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="498" mass="56847" checksum="EAF1647D185FE345" modified="2017-04-12" version="1">MHEIVTLQLGQRANYLATHFWNLQESYFTYKEGEESPVDHDVHFRPGVGADGSETYTPRTVIYDLKGGFGTLRKHNALYELTEDAMAGQGLWDGLEIIQKQAPIQQSEYQRSLDQGTTAPRLTSETVRYWSDYNRVFYHPRSAVQLNEYELNSQVMPFEDWNVGEDLFNDLDKEHDLLDRDVRPFAEECDQMRTIQLFTGSDDAWGGFAARYIDRLRDDYGKKSIWIWAIEDGTRVQRHHQFKRDTNKAKSLYSISPQANLYVPLVDIPQKLPSYISVDRHSEWQRSALLSAAVETITLPSRLRPYHDFEASLAGDDGRHNIYELQSTFNPENQYEKAPKSDTEGSSKPQTKFDIDFTYDNQDTETATIFNQVQMMRGNETETSTQSPESGDIGHLRKLRLYNSEPMLQSYHSPLRLPIIDSFPHGMFSASPSSADGLSIFTALTASTRTADRIKAIQATAARMLSVDEREAMVNGLGEIRECYETGWSSGSSDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0M7</accession>
    <name>A0A1Q5T0M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_12106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0M7"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO93827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="82" mass="8598" checksum="5812D89BE8F877A1" modified="2017-04-12" version="1">MDRGGVGPSNPLLNSDPPCTHPDRLLGVGGYSVSGRPLLVLGPSAEWGWEEEGAGIGSNTVIYLVPIEIQLTRGNEGVRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0P7</accession>
    <name>A0A1Q5T0P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidoreductase YusZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0P7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0P7"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31416" checksum="CEB4F252380F1AB5" modified="2017-04-12" version="1">MAKQLTWLVTGCSSGLGEAMVRAILAKGDKVIATARASQGISGSERLSALKEAGAAALELDVTSPQEQLDELAKTAWGVYGHIDVLVNNAGYIENGILEEMSEELVTRSLRANALGPINLTRSFLPMMRARKTGTLLFVGSVSVYYTMPSTSSYIGSKALLEGLATNLAVEVAPFGLRTSILTFGHFRTDILCPSNLHARAPNKLSDYVEANNEVRERIKNAHGTWPGDARKGCDLVVDAVRGEGRCAGKDLPLRLPIGSDTFGIMREDLQKRLQVCDEWENIMSKTDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T0V1</accession>
    <name>A0A1Q5T0V1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_12099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T0V1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T0V1"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="325"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO93820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44879" checksum="B7875F3EB1B3750C" modified="2017-04-12" version="1">MTILPSPLAQSTLGEKCALYLDHVSDHLPVFLHSLRPRLDPYLTYSTTTLRSVAQALPFDVDEQTTALGAALLLGLLTVVAMSWGNPFNNFWRRSPNYPPAAPQVRDDDYSYITPEYIVDPPSQPARYGAQYEAGAAENEPDIICLKHRGTIYPLHFRAYAIDDGLLTVGDLRHTAAAKMGASNPNQIRLLYKGNLLKDDARTCKAEGLKQHSQVLCVVSEAGSNTPSDLSDYDSAHADIPVIRPGSSSSLVDGDDAPGPANPPSKKKNNKKKKKKGGKRSEERLAPETLAPSPSLAPPRPTSAGHSAAPSPSPSMKTLKTPLDQVTALTEYLKRELIPLCDEYLADPPTDPKKREFEYRKLSETILAQVMLKADGIEPDGNETVRNARKALIREAQASLNRLDEVGRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T183</accession>
    <name>A0A1Q5T183_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">PENSUB_12211</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T183"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T183"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OKO93932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="202" mass="23288" checksum="131B916F204C3E84" modified="2017-04-12" version="1">MLAILENNFDYSIYTYRTYVVSSGDDLSTQKAVEFEDTIAQQKDSKELTENYAIVTIPRARRVHQSYLTAPFSTLHCFWTCLLVLLGRHPNQRPLPTQYTSKHPDIIISNGPAVAVCMILAAKFIRFFIYCFRWASGRGSKPEISRLRTVYVESWARVRTLSVSGRILLPIADKFLVQWLPLAGRRAWWGMKESEYCGWVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T1C4</accession>
    <name>A0A1Q5T1C4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">PENSUB_12184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000723">
        <property type="protein sequence ID" value="OKO93905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T1C4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T1C4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OKO93905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="460" mass="49896" checksum="B9320AE83F7AA9D0" modified="2017-04-12" version="1">MGKDDRLHINIVVIGHVDSGKSTTTGHLIYKCGGIDTRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFQTAKYEVTVIDAPGHRDFIKNMITGTSQADCAILIIASGTGEFEAGISKDGQTREHALLAFTLGVRQLIVALNKMDTCKWSEDRYNEIVKETSNFIKKVGYNPKSVPFVPISGFNGDNMLEPSPNCPWYKGWEKETKAGKTTGKTLLEAIDAIEPPVRPSNKPLRLPLQDVYKISGIGTVPVGRVETGIISPGMVVTFAPANVTTEVKSVEMHHQQLKEGVPGDNVGFNVKNVSVKEVRRGNVASDSKNDPAAAAASFNAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSELLEKIDRRTGKSVEDHPKFIKSGDAAIVKMIPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVDKSAAGAGKVTKAAQKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T4A0</accession>
    <name>A0A1Q5T4A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isotrichodermin C-15 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_11301</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000707">
        <property type="protein sequence ID" value="OKO95059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T4A0"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T4A0"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO95059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="579" mass="65874" checksum="FD355A2FD2286BE4" modified="2017-04-12" version="1">MQPEDFSNPSSWSPPDPDPGSASFQPPDVDMSSTEDSTNDVEGSIFDNDDYYHSDTSSYTASLLSDVEDYAYENGRRYHSYREGLYVLPNDEQEQDRQDLLHHVRNLVLNGALFRAPLDNSIQRVLDIGTGTGIWAIDFADSYPSAEVIGTDLSPIQPSWVPPNLRFLVDDAEEPWLFSASRPFDFIHARDLGGAIADWPRLLRQAHEHLKPGGWIELQEFEVTLKSDDDTMRLAPTLCEYLDRLHEASEAFQRPMNIAEGHRQRLVEAGFEDVRDEVYKVLLVFAYSIVYQLFFSPLACFPGPRLWAISRVPNQWSVFRGYAHLDATTLHERYGPVIRVGPNELVFNTPRAFRDIYGARPGGCFQKDPSRYLAPANGVNHLIGEIDNASHARQRKLLAPAFSDRALREQEPLITGYVDTMISKVRAEIQKGSSVLDIKNWMNYTTFDIAGDLMFGESFGCLKDSQLHPWIDLIFKSIKALAYDGMARQFPVFHSLLSALIPKGVKQKAVEHFDLAARRVDRRLETKTTRSDFMSAILQNGLSESKEQDHDGPRMMTRAEIHSNAFMYVLSVKLRRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5N9</accession>
    <name>A0A1Q5T5N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_11044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5N9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5N9"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO95532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="355" mass="37431" checksum="887EC204C8DC9FAD" modified="2017-04-12" version="1">MASPQVIRTPITDLLKINHPVLLAGMNVAAGPKLAAAVTNAGGLGVIGGVGYTPDMLREQVAELKSYLKDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLNELVDIIIESGAKLFVSAVGVPPKAVVEKLHGAGILCMNMIGHPKHVQKALDVGIDIICAQGGEGGGHTGDVPTTILIPTVAKLVQGRKSPLTGQPVQVIAAGGLFNGNSVAAALMLGASAVWIGTRFILSEEAGAPVAHQEAVRTAGFEDNIRTIIFTGRPLRVRKNAYILNWEENRADEIKQLTAKGIIPVEHDFENLPDDVDDDTLDNARPFLMGKVAAVVNEKKSAKAIVDELVTDAAALLKKGNQMVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T5Y9</accession>
    <name>A0A1Q5T5Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_11159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000702">
        <property type="protein sequence ID" value="OKO95647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T5Y9"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T5Y9"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO95647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122072" checksum="4386C8A24E8FD0FE" modified="2017-04-12" version="1">MAPINDAVFLRRNNQIQDAIDGQNLKQALQLIEKRMKKGEDTPFLKAWKAHILWRHADEAHHKRGIAETLELCKVEPPITDIDTLDILFKTLQKLDGQDATRSNLWERAAKAKPQDLEIQGRWFTYAFESNDWKSAQKAAMSLQKNFPKDRKYYFWAIFLSHMIAIDDASSETDRKLFGTLAYRMISKAAADVPEASQLLSPPRAIQTSEELRLLIKIYEAQGRNAEIVKILDSENLGLKSRIVQNDTAFLGYKSHNLSSSKMWEEGISFVRELYTVPDDKEKLKALRELDDWSIWNLLVQGTKHSNTPGTATESANFAETFMASSPKSRNAALAYLDAMICGISNGEIAKDDLLPACQRYIDNHIHKLYAFSDIRRIIGPNKEGLAKMLNYILENHVVEGKGSVPMINALKLDYCLNISGPESKPSQQKIDDLVARCLKLYQTAYEEGKAKKSTGGAQGASSTIESQPIDDLCILAAMCLLQPTEMGEKEAQIPGTALIRAAGILERLCRDSPHNYEALLLLVRVYLLLGAGSLALSTFSKLSVKQIQYDSVAHVLFTRLSTVHPHSAPPVDGAEYKDFDPLSAFVQGLNFFRNSEVNTMRYRTAGLDEGSYVNTEEIIELRRCLSKSINRRMYALDARRIQRLAGGDPMTRYDELARDSSPVVDSRKFGAFMSCEYPGKPSFEERMRLGPLPRTNWLASARITDQLFSILKGISLQRPLSPEMDLPSLESLSISETENDQTAAEKESVKIHTDLLRVATFMAGSKLTASEQVDAALGRVGDFLESKKKDLTLSETATSQLIASTAVFLEADTPAGPTWKYLHSTFVLLETIKALSQLLALAVKKGAKSAKLPKERVERLSILVSEIYELVRSNTRALKQRVSASGVLTSLVDLVIQGDQSAKSEKEVQDVLETTLDPSNVEVFCGALMESWEEALVGVMGFRLRTNARAKTRSCAVPEALGDFHKTFFIPFPRQLRQSPQSPTVQMAQERTGIVVGTNKGHKTTPLNTPKNKISRSKGKSSRRTAFVREIAREVVGLAPYERRVIELLRNAQDKRARKLAKKRLGTFVRGKRKVEDMQKVIAEARRTTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8I4</accession>
    <name>A0A1Q5T8I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxidoreductase YfjR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_10670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8I4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T8I4"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF3">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="180"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO96495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="33327" checksum="A4C4496C0F56D715" modified="2017-04-12" version="1">MSGVRVAWIGLGNIGRGMSSNIAQKGPQSSLILYNRTTSRATAHAEKLGGNVKVATSLIEAVQASDLIFTCVGDDPAINSITETILSDKETDFSTKTFIDCSTVHPDTSRRTEAAYEARGASFVACPVFGAPNMADAGQMIVVPAGKQSAIAKARPFFEGVVAKATIDLSSGTGEDIDVGRASTLKVLGNTFILNTVGVLAESLTAADATGLGTGPFRQWLELFNPGPFTKYADRMISGDYYQREEPLFAVDLARKDLRHASNIAKEGGQRMRNVEVTDHFLQEVKAEKGEKGDIAAVYGAARKAAGLKFENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T8V2</accession>
    <name>A0A1Q5T8V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">PENSUB_10829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000698">
        <property type="protein sequence ID" value="OKO96654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T8V2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OKO96654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="83" mass="8891" checksum="45D31FB817B8849F" modified="2017-04-12" version="1">MSVSEIPHTPEERERPKAACKGLGSALDASCGGWTTWNALTSFDNVFWKGDRKATLGQIQCGRYQSKSGSEMANQLGGLVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5T9H7</accession>
    <name>A0A1Q5T9H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HET-C domain protein HetC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_10453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000697">
        <property type="protein sequence ID" value="OKO96899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5T9H7"/>
    <dbReference type="STRING" id="1316194.A0A1Q5T9H7"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012343781" description="HET-C domain protein HetC" evidence="2">
        <location>
            <begin position="26"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO96899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="80054" checksum="AA2843988F2A1A72" modified="2017-04-12" version="1">MPLLRAGSPALLVCLLLVLLPQVHAFGAGNIASISAVEGKNWRHGDIEDMLKTITFIAGHKWTSTMIKRVYFGNWLRDYSQAMDVGTLKNLQADTIRILVWVLSFLTFGYATGEFEVTSERLGVYRPEEHIDNPKDYADNEDARQFDKRLRGPVRQVELDIDPETGMKNYIANERGDWATSTAFVKFSLSRSIHYGRMYTSGGHHKGKEEDLCEALRCLGQGLHTLEDFAAHSNYIELALREMGFHNVFPHTGTATQCNIRGHHVFPLVTGTFGMVDFFHSVLGEATDHFTQSEVNEMDIALGDAQTNAQAGNSLNSLTGLLGKIPGTRDLVTEAENLKQQSEAQERSNRSHGSHTGYVQTGGFDQTRAPDPSHPMTGGAAPGPGLQGMPDFNPQETVSKIYPILAFRDKVVRKLNAVIEKIPGLETIVEKITETLTVFIMSLLAPFIRPLINAASKSLQTGSSGVISASGKHQYEPWTDPHCTDPTHSLLSKDHFANILNEPAGQVASAILKYVAPRVLYAWQHIDVPEHEVLDDCMRIFHHPVLRDMHNEAHRTMFEAVGNWVHSREDRGSRLNDILSAEGVRNGRNTGGVPHTHGGSQGGFAALGGAAHGQSHGQAHGQGQGHGFSVGGIQSFFTQGQGQHQQPSGSHGQSSSGLPWDKLSKLPIPGMSNLNRLESTISGFIPGGLSHGSRRELDDDDEAGSGHAQGNASYQQQPSGYHGQQGHGQGGHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB05</accession>
    <name>A0A1Q5TB05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_10175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB05"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB05"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="299" mass="32200" checksum="2B75F3E8968A01A2" modified="2017-04-12" version="1">MATFKNIALVGASGAIGKIILDGLMASSSFTITVISRNESNAVFPEGIAVHKSDFSDEDLEAVFKGKDAVISALGATGFSEQQKLVDAAIRAGVKRFIPSEFSANSQNDAVIQLLPLFGQKKALIEYLKSKEVDGLTWTGVATSGLLDWGLENGFLQFDLANRTATIWDGGHKSFTLINEKALGQSVVSVLQNPEQTKNKYLHVASVETTQLEILEALEKATESKWTVRETTTEAQLSEAGVKLAAGDFEGAFILVRATVFGNTPGLNSNYVKDTELANDILGLKLESVEETVRRVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TB28</accession>
    <name>A0A1Q5TB28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_10207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="MNBE01000695">
        <property type="protein sequence ID" value="OKO97413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TB28"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TB28"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000044">
        <property type="entry name" value="Deoxyribose-phosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OKO97413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="272" mass="29030" checksum="0D66EE6F54C539EE" modified="2017-04-12" version="1">MPKPNMSSIPSTDAEWTAAISSLKERGPERPLSPPACPLHIQAMIDHTLLKVPTEPEQIDVLCQEARENGFATVCVRLNFVAQAATNLKNTPNVGVACVVGFHEGTYDTQDKVKEALEAVAQGARELDMVINYPKLKNGEYTAVYNDILAVRRAAPAPVLLKAIIEASELDRDQIIAATIISCMAGVDYVKTSTGYKGPATMDHIMTMRIAAEAAGYPNIGIKASGGIRNARDALRMVKAGATRIGASAGVSIARELEDGEITEQGASHAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TC90</accession>
    <name>A0A1Q5TC90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">PENSUB_9761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TC90"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TC90"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OKO97835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="180" mass="20341" checksum="7A4AD32131F28B33" modified="2017-04-12" version="1">MIIYEDIISGDEILSDTFKITPSKDCPILWETDCRKYLKKKNEDFELAGANPSAEEAGEDGGDDEAVMVHDIEDQFRLVWLKTEEGLKPSKEAFKSHLKGYLKKLLKKLEETGASAETIDEFKKNAPAAMKKIIANYDNYDVLMGSSMDGDAMHVLIDFREDGVTPFATVWKHGFREVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCE4</accession>
    <name>A0A1Q5TCE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">PENSUB_9805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 132785</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="MNBE01000683">
        <property type="protein sequence ID" value="OKO97879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCE4"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCE4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072330">
        <property type="term" value="P:monocarboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OKO97879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="426" mass="46645" checksum="FBCF7CE6DB112E32" modified="2017-04-12" version="1">MPPTGSPACSSGSSHLPIQKQIKSSLDGLLQENGPFLWQSGTYAPVRNPFSWSNLTNIVYIDQPAGTGLSPGPATVQNEIDVSNQFNGFWKRFIQTFSMQGYKIYITGESYAGQYIPYLASGMLDQNDTTHFNLKGIQINDPSINEDNVMIYAPAVPALNYFSTVFSLNDTFMTEINKRADECGYNQFLDKALTFPPPKHFPTAPDPSRRGCDVWDQIIKAATYINPCFNIYHLTDFCPFLWDEMGFPSLAGGPNNYFNQSAVQKALHISPTNYAVCGGNIFPNGDGSAPSALGPLPSVIERTNNVLIGHGWYDYLLFMNGTLATIQNMTWNGLQGFQKPPVEPLLVPYTDSLNAIANGNGQVPFTADAGAGILGTAHTERGLTFSTVYGSGHEIPQYTPGAAYRQLEFLLGRIKSLQDTGPFTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCS1</accession>
    <name>A0A1Q5TCS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ureidoglycolate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">PENSUB_9598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCS1"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCS1"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.480:FF:000002">
        <property type="entry name" value="Probable ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OKO98018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="261" mass="28088" checksum="DFD93A40069BCFA0" modified="2017-04-12" version="1">MAPTLTSNPSLTLVPEPLTPASFAPFGTAICSPLPREISVAPQPSSLPPYNPTPVLANQNSALKYSPISPLIDRYTNGCPSGKPASARMTMFCCFPRKLRTISAKQQADKEVFDVRILERHPFTNQTFIPTDLSSHSKVGDGEEEPVFLVVVAPTLKGEVATAKNAAGETITIRDPPDLRNVKAFIARGGQAVTYGVGTWHAPMVVLGPRRVDFVVVQHVNGVDDEDCQEAAFGEGIVVDLGVTGQYGRPEKTPARLWAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TCS2</accession>
    <name>A0A1Q5TCS2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_9602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000682">
        <property type="protein sequence ID" value="OKO98022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TCS2"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TCS2"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="423" mass="47674" checksum="706CA02CBFF60A62" modified="2017-04-12" version="1">MRPSISNTLSHLFKECRPQSIRLERGLSRYSQSQSLQIYNESSKRMILLSTKVGIPGIPRRALHINQQIRAIQTKPTPQEIMNLSLKLSHGRMNGTTELICTLFDANGAIEMPETRLTKADIARQYGVDGRDLRTADAISEGIPHFVIRPSTIFISLFSLRLLVQSNRVLLIRSGSKDNDPHAFLEEIFATDLQSKLRGNHGSGFPVSLPYELRVFEAALASVTAHLEAEHLLIRKEIEYSLEDLQSEDIASTGPRTLLENGKKLVHIEQRARQMRTALQELLSNDEDLAEMYLTDQQAGRPHAIEDHQEVEYLLEAYYKSHDAIVESAGALLSEVHRTQDAIMSVLDVRRNQIMVFEAQLEICMLGFAVSTFIAGLYGMNVINYLEDSPYAFPSLVAGCVMGTLMLARIGMLKLRKFRRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TD36</accession>
    <name>A0A1Q5TD36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">PENSUB_9517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000674">
        <property type="protein sequence ID" value="OKO98133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TD36"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TD36"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="220"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OKO98133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="336" mass="37900" checksum="F29DC5004EE79E4E" modified="2017-04-12" version="1">MAVGGRRPGQTLRSSHASSAATVSTPATPAGAYHGRSPGDNSNAPLQGAVVAFDISKAYSVIWPATWMKGRMPDGFQSASAASCVATTSKPILQRMALCDRIRFLVCDNLSDKEILLILHHEGFKIAPITLKRLRQQLGLRLRTDDPKARALQAQQIREVVQQEIHDGKIEGFGRGLLHTYLRQKGYVFPCNRVFSIYRDERPDALRRRTLDLQRQRQAYRSPGPNHVWHMDGYMKLSGYGIEIYAAIDGFSRYILWIYVGISTRTAISVYRQYVDAVSTFGYIPRILRTDLGGETIHLGDAHWALRRVHEPDLPHEDCYSYGNSTENTRIEAWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TDZ8</accession>
    <name>A0A1Q5TDZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">CENPA homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Histone H3-like centromeric protein CSE4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">PENSUB_9131</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 132785</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000672">
        <property type="protein sequence ID" value="OKO98455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TDZ8"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TDZ8"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="57"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OKO98455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="157" mass="17105" checksum="A18360D0995F1C9D" modified="2017-04-12" version="1">MPPTAKKTAKAPAAKTAAASPASAARKTAAKKTAGKRASNVQPGDPTPTGKKRRYKPGTVALKEIRRYQRSYDLLIAKLPFARLVREVALDLLPAEVGAELRWQSHAIQALQEAAEAFMVHLFEDTNLCAIHAKRVTIMQKDIQLARRIRGVWGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TEF4</accession>
    <name>A0A1Q5TEF4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">PENSUB_9037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000670">
        <property type="protein sequence ID" value="OKO98597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TEF4"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OKO98597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="176" mass="19895" checksum="323CAB504505D7DC" modified="2017-04-12" version="1">MYGRRRRPLLGAAVLVGASRASARHEIQRQAALDYQREMVMRQELEAQRLRDEEQEKATRRLVQEEVQRATSNNPNTASSSMDSSQPLQQLHNSPPPSYPPAYHESNIRPGDATPTNSRQVSARDNIYNNHESEASTGPEVAGKTRHCTQCGVVCQVQDRFCWKCGAKHVIQEDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF09</accession>
    <name>A0A1Q5TF09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">PENSUB_8741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 132785</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF09"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF09"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OKO98824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000186955"/>
        </source>
    </evidence>
    <sequence length="407" mass="47131" checksum="1F57E3EB3B59FB84" modified="2017-04-12" version="1">MATIMRGITKAPRRAASPPLCFPPNDFETVPDWEVLEEEWFDKFKKRQYYPANIGEVLHSRYQIVGKLGFGGTSTVWLARDLQGHRYVALKIYTRGEGSRNDFEIYKQLDQGPSHPAYDFVRRALDIFTIPRPGGDHSCIVLVPMWESFRDFLDRNPVRRFPVSILKMGLVQIFAALDFLHTECKLVHTDINSSNVLHELKEESLFERFTQAEMQNPSRRKIVNDMPVYASRRFDRQMLHGHAVLGDVDSAVSGEKTWNHDVQPNVYRSPEVMLGTGWSYPVDIWNAGVMAWDLFEGRRLFYGNEPDGRGYSTRAHLAEVVALMGPPPLDMLQRGKRSLEFFTEDGKWKQDINIPKGISLEMSEEFLEGKDKKMFLAFMRKMLQWRPEDRETAGELFFDPWLNGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A1Q5TF29</accession>
    <name>A0A1Q5TF29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrogen assimilation transcription factor nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">PENSUB_8745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Penicillium subrubescens</name>
        <dbReference type="NCBI Taxonomy" id="1316194"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Penicillium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-10" db="EMBL/GenBank/DDBJ databases">
            <title>Genome sequence of the ascomycete fungus Penicillium subrubescens.</title>
            <authorList>
                <person name="De Vries R.P."/>
                <person name="Peng M."/>
                <person name="Dilokpimol A."/>
                <person name="Hilden K."/>
                <person name="Makela M.R."/>
                <person name="Grigoriev I."/>
                <person name="Riley R."/>
                <person name="Granchi Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 132785</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MNBE01000665">
        <property type="protein sequence ID" value="OKO98828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A1Q5TF29"/>
    <dbReference type="STRING" id="1316194.A0A1Q5TF29"/>
    <dbReference type="Proteomes" id="UP000186955">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
 
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